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2. Evaluation of trifluperidol in chronic schizophrenia

Author

Ray Ts, Huber Wk, A. A. Kyriakopoulos, Colmore Jp, Clark Ml, and Ramsey Hr

Subjects
Pharmacology, Drug, medicine.medical_specialty, Experimental drug, business.industry, Butyrophenone, media_common.quotation_subject, Trifluperidol, Placebo, Clinical trial, chemistry.chemical_compound, Antipsychotic Agent, chemistry, Internal medicine, medicine, Chlorpromazine, business, medicine.drug, media_common
Abstract

Trifluperidol, a new butyrophenone compound, was evaluated in chronic schizophrenic women under conditions of a controlled clinical trial. Within this framework significant drug effects associated with the standard drug, chlorpromazine, attested to the sensitivity of the experiment, while trifluperidol, the experimental drug, was shown to be an antipsychotic agent at least equally as effective as the standard. The placebo group tended to deteriorate on all measures. This trend did not differ significantly from a similar trend in a group of subjects receiving neither placebo nor active treatment. The most likely explanation for this deterioration is thought to be an inadequate preliminary dry-out period, although other influences affecting all subjects adversely can not be ruled out. The demonstration of significant drug:placebo differences was dependent in part upon the presence of the negative change in the placebo group. Failure to include a control group in the present study would have precluded the demonstration of statistically significant drug effects.

Published
1968
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3. Treatment of Acute Bromide Intoxication with Hemodialysis

Author

Jobe Cl, Donat Pe, Colmore Jp, Hicks Dl, Matter Bj, Hummer Lm, Everett Ed, and Ginn He

Subjects
Bromides, business.industry, medicine.medical_treatment, General Medicine, Toxicology, Blood–brain barrier, Alcoholism, Blood, medicine.anatomical_structure, Cerebrospinal fluid, Fluid therapy, BROMIDE INTOXICATION, Blood-Brain Barrier, Renal Dialysis, Anesthesia, medicine, Fluid Therapy, Humans, Hemodialysis, business, Dialysis, Cerebrospinal Fluid
Published
1964
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4. Drug treatment in newly admitted schizophrenic patients.

Author

Clark ML, Huber WK, Charalampous KD, Serafetinides EA, Trousdale W, and Colmore JP

Subjects
Adolescent, Adult, Chlorpromazine adverse effects, Clinical Trials as Topic, Fluphenazine adverse effects, Humans, Middle Aged, Placebos, Psychiatric Status Rating Scales, Thioridazine adverse effects, Chlorpromazine therapeutic use, Fluphenazine therapeutic use, Schizophrenia drug therapy, Thioridazine therapeutic use
Published
1971
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5. Trifluperidol and cholesterol in man.

Author

Clark ML, Braun GA, Hewson JR, Serafetinides EA, Colmore JP, and Rahhal DK

Subjects
Adult, Antidepressive Agents therapeutic use, Butyrophenones therapeutic use, Clinical Trials as Topic, Depression, Chemical, Humans, Male, Middle Aged, Piperidines therapeutic use, Placebos, Trifluperidol pharmacology, Trifluperidol therapeutic use, Antidepressive Agents pharmacology, Butyrophenones pharmacology, Cholesterol blood, Fluorine, Piperidines pharmacology, Schizophrenia drug therapy, Sterols blood
Published
1968
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8. Treatment of urinary-tract infections with nifuradene.

Author

Braden B, Wilkerson R, and Colmore JP

Subjects
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Escherichia coli Infections drug therapy, Klebsiella Infections drug therapy, Nitrofurans administration & dosage, Urinary Tract Infections drug therapy
Published
1967

9. Evaluation of trifluperidol in chronic schizaphrenia.

Author

Clark ML, Huber WK, Kyriakopoulos AA, Ray TS, Colmore JP, and Ramsey HR

Subjects
Adult, Chlorpromazine therapeutic use, Chronic Disease, Clinical Trials as Topic, Female, Fluorine therapeutic use, Humans, Middle Aged, Placebos, Trifluperidol therapeutic use, Antidepressive Agents therapeutic use, Butyrophenones therapeutic use, Piperidines therapeutic use, Schizophrenia drug therapy
Published
1968

11. Objective assessment of antitussive agents in patients with chronic cough.

Author

Sevelius H and Colmore JP

Subjects
Aged, Bronchitis complications, Clinical Trials as Topic, Evaluation Studies as Topic, Humans, Male, Middle Aged, Placebos, Pulmonary Emphysema complications, Tape Recording, Antitussive Agents therapeutic use, Codeine therapeutic use, Cough drug therapy
Published
1966

12. Trifluperidol in chronic male psychiatric patients.

Author

Serafetinides EA, Colmore JP, Rahhal DK, and Clark ML

Subjects
Adult, Chlorpromazine therapeutic use, Cholesterol blood, Chronic Disease, Fluorine therapeutic use, Hospitalization, Hospitals, Psychiatric, Humans, Male, Middle Aged, Prognosis, Psychotic Disorders blood, Psychotic Disorders diagnosis, Sex Factors, Trifluperidol therapeutic use, Antidepressive Agents therapeutic use, Butyrophenones therapeutic use, Piperidines therapeutic use, Psychotic Disorders drug therapy
Published
1971

14. Dose response to codeine in patients with chronic cough.

Author

Sevelius H, McCoy JF, and Colmore JP

Subjects
Administration, Oral, Aged, Bronchitis drug therapy, Chronic Disease drug therapy, Clinical Trials as Topic, Emphysema drug therapy, Humans, Male, Middle Aged, Placebos, Time Factors, Codeine administration & dosage, Cough drug therapy
Published
1971
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17. Lack of dependence and withdrawal symptoms in healthy volunteers given high doses of tybamate.

Author

Colmore JP and Moore JD

Subjects
Adult, Blood Urea Nitrogen, Carbamates administration & dosage, Carbamates adverse effects, Carbamates blood, Clinical Trials as Topic, Depression chemically induced, Humans, Male, Middle Aged, Tranquilizing Agents blood, Substance Withdrawal Syndrome, Substance-Related Disorders, Tranquilizing Agents administration & dosage
Published
1967
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19. Comparative cardiovascular effects and metabolism of proscillaridin A and of digoxin.

Author

Nakano J, Norrby A, and Colmore JP

Subjects
Animals, Blood Pressure drug effects, Cardiac Glycosides blood, Digoxin metabolism, Digoxin pharmacology, Dogs, Heart Atria, Heart Rate drug effects, Heart Ventricles, Hemodynamics drug effects, Kidney metabolism, Liver metabolism, Myocardium metabolism, Stimulation, Chemical, Time Factors, Tritium, Cardiac Glycosides metabolism, Cardiac Glycosides pharmacology, Cardiovascular System drug effects
Published
1970

20. Further evaluation of the Griess test to detect significant bacteriuria. II.

Author

Czerwinski AW, Wilkerson RG, Merrill JA, Braden B, and Colmore JP

Subjects
Evaluation Studies as Topic, False Negative Reactions, False Positive Reactions, Female, Humans, Indicators and Reagents, Methods, Pregnancy, Refrigeration, Specimen Handling, Bacteriuria diagnosis, Nitrites urine, Pregnancy Complications, Infectious diagnosis
Published
1971
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25. Evaluation of daily student performance.

Author

Colmore JP

Subjects
Curriculum, Faculty, Medical, Humans, Learning, Schools, Medical, Education, Medical, Educational Measurement, Students, Medical
Published
1966

27. Ocular pigment deposits: drug-induced false-positives.

Author

Clark ML, Serafetinides EA, Wise JB, and Colmore JP

Subjects
Butyrophenones metabolism, Chlorpromazine metabolism, Humans, Pigments, Biological metabolism, Placebos, Sulfides metabolism, Xanthines metabolism, Lens, Crystalline, Pigmentation Disorders chemically induced
Published
1970

31. Evaluation of first morning urine to detect significant bacteriuria. I.

Author

Czerwinski AW, Wilkerson RG, Braden B, Merrill JA, and Colmore JP

Subjects
Enterobacter isolation & purification, Escherichia coli isolation & purification, Female, Humans, Klebsiella isolation & purification, Pregnancy, Proteinuria diagnosis, Proteus isolation & purification, Pseudomonas aeruginosa isolation & purification, Pyuria diagnosis, Specimen Handling, Staphylococcus isolation & purification, Time Factors, Bacteriuria diagnosis, Pregnancy Complications, Infectious diagnosis
Published
1971
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33. Metabolism of iron.

Author

GITLOW SE, BEYERS MR, and COLMORE JP

Subjects
Hemochromatosis diagnosis, Iron, Iron Compounds metabolism, Liver Cirrhosis diagnosis
Published
1952

34. Pimozide in chronic schizophrenic patients.

Author

Huber W, Serafetinides EA, Colmore JP, and Clark M

Subjects
Adult, Analysis of Variance, Benzimidazoles therapeutic use, Chronic Disease, Clinical Trials as Topic, Extrapyramidal Tracts drug effects, Hallucinations chemically induced, Humans, Male, Piperidines adverse effects, Piperidines therapeutic use, Placebos, Psychiatric Status Rating Scales, Social Desirability, Thioridazine therapeutic use, Psychopharmacology, Schizophrenia drug therapy
Published
1971

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