1,679 results on '"Colonic disease"'
Search Results
2. Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome
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- 2024
3. Evaluation of the Contribution of Low-pressure Intra-abdominal Insufflation for Laparoscopic Colic Resection (LoPreCol)
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- 2024
4. GastroBot: Artificial Intelligence Applied to Bowel Preparation
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Manuel Valero, Medical director
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- 2023
5. Effect of Lavender Oil Inhalation in Colonoscopy Patients
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Kırklareli University and SELDA MERT, Assist. Prof. Dr.
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- 2023
6. Capsule Endoscopy as an Alternative to Colonoscopy (CAPSUCOVID)
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Medtronic and Begoña González Suárez, MD PhD
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- 2023
7. Immediate Versus Early (24-hours) Urinary Catheter Removal After Elective Minimally Invasive Colonic Resection
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Faenza Hospital, Ravenna Hospital, IRCCS Humanitas Research Hospital, Humanitas University, and Universita di Verona
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- 2023
8. Written Recommendation to Improve Adherence in Poor Bowel Preparation
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Miguel Angel Pantaleon Sanchez, MD-PhD at Hospital del Mar
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- 2023
9. Performance of the Poseidon System for Fluid Management During Water-aided Colonoscopy
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- 2022
10. Patients Decision Making in Choosing Between Colonic Investigation Alternatives
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NHS Highland
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- 2022
11. Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases
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- 2022
12. Comparison for Efficacy and Safety of Bowel Preparation Between Oral Sulfate Table and 2L-polyethylene Glycol/Ascorbate in Elderly
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- 2022
13. Development and Validation of an Artificial Intelligence System for Bowel Preparation Quality Scoring
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Dae Kyung Sohn, Staff surgeon
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- 2021
14. Research on Operating Handle of Colonoscope (ROHC)
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- 2021
15. Factors Related to a Persistent Inadequate Bowel Preparation for Colonoscopy (REPREP)
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Lorenzo Fuccio, Principal Investigator
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- 2021
16. Solitary cecal ulcer - case report and treatment options according to literature review
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Kunkin Vanja and Ognjenović Aleksandar
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ulcer ,rare disease ,cecum ,colonic disease ,Medicine - Abstract
Introduction. Solitary cecal ulcer is a benign and extremely rare disease, as less than 300 cases have been reported so far. The etiology is unknown, and it can be diagnosed by pathohistological examination. Often presented as an acute abdomen and rectal bleeding, it can mock various important and urgent conditions. Treatment protocol is not defined. Extensive and radical surgeries are often performed due to this benign disease mimic. Our aim was to indicate this disease, present the treatment of this rare condition, and to facilitate the treatment plan for this disease. Case outline. Female, aged 67, was admitted to the Emergency Department with a clinical manifestation of acute appendicitis. Emergency surgery was indicated after following diagnostic tests. The intraoperative finding revealed an ulcer on the cecum, which was sutured. The patient fully recovered, and subsequent colonoscopy and pathohistological findings indicated a solitary ulcer. Conclusion. It is possible to treat this condition by retaining the organ and avoiding major surgery. Therefore, it is our opinion that it might provide significant assistance to clinicians in a similar situation. Hence, it is undoubtedly an interesting case for archiving, especially since such a case has not been recorded in our country yet.
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- 2022
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17. Evaluation of the PillCam™ Colon Capsule Endoscopy (PCCE) in Detection & Classification of Ulcerative Colitis
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- 2019
18. Study on Analgesia of GIC-1001 & GIC-1002 on Visceral Pain, Rectal Sensory Threshold Using the Barostat Method
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Algorithme Pharma Inc
- Published
- 2016
19. Anorectal and Colonic Crohn’s Disease
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Mortensen, Neil, Travis, Simon, Givel, Jean-Claude R., editor, Mortensen, Neil, editor, and Roche, Bruno, editor
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- 2010
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20. Surgical Treatments for Colonic Diseases
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Muldoon, Joseph P., Stryker, Steven J., and Koch, Timothy R., editor
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- 2003
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21. Aging
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Opara, Emmanuel C., Koch, Timothy R., and Koch, Timothy R., editor
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- 2003
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22. Micronutrients
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Opara, Emmanuel C. and Koch, Timothy R., editor
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- 2003
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23. Observer agreement for small bowel ultrasound in Crohn’s disease: results from the METRIC trial
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Gauraang Bhatnagar, Stuart A. Taylor, Laura L. Quinn, Metric study investigators, Antony Higginson, Roger Lapham, Susan Mallett, Damian Tolan, Andrew Plumb, and Steve Halligan
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medicine.medical_specialty ,Urology ,Hollow Organ GI ,Gastroenterology ,Cohen's kappa ,Crohn Disease ,Internal medicine ,Intestine, Small ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,Colonic disease ,Ultrasonography ,Observer Variation ,Crohn's disease ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,Hepatology ,medicine.disease ,Magnetic Resonance Imaging ,Cohort ,business ,Kappa - Abstract
Purpose To prospectively evaluate interobserver agreement for small bowel ultrasound (SBUS) in newly diagnosed and relapsing Crohn’s disease. Methods A subset of patients recruited to a prospective trial comparing the diagnostic accuracy of MR enterography and SBUS underwent a second SBUS performed by one of a pool of six practitioners, who recorded the presence, activity and location of small bowel and colonic disease. Detailed segmental mural and extra-mural observations were also scored. Interobserver variability was expressed as percentage agreement with a construct reference standard, split by patient cohort, grouping disease as present or absent. Prevalence adjusted bias adjusted kappa (PABAK), and simple percentage agreement between practitioners, irrespective of the reference standard, were calculated. Results Thirty-eight patients (11 new diagnosis, 27 relapse) were recruited from two sites. Overall percentage agreement for small bowel disease presence against the consensus reference was 82% (52–95% (95%CI)), kappa coefficient (κ) 0.64, (substantial agreement) for new diagnosis and 81%, κ 0.63 (substantial agreement) for the relapsing cohort. Agreement for colonic disease presence was 64%, κ 0.27 (fair agreement) in new diagnosis and 78%,κ 0.56 (moderate agreement) in the relapsing cohort. Simple agreement between practitioners was 84% and 87% for small bowel and colonic disease presence respectively. Practitioners agreed on small bowel disease activity in 24/27 (89%) where both identified disease. Kappa agreement for detailed mural observations ranged from κ 0.00 to 1.00. Conclusion There is substantial practitioner agreement for small bowel disease presence in newly diagnosed and relapsing CD patients, supporting wider dissemination of enteric US.
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- 2020
24. DCBE and colonoscopy
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Cittadini, Giorgio and Cittadini, Giorgio
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- 1998
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25. Crohn’s Disease
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Fisher, Scott, Millikan, Keith W., editor, and Saclarides, Theodore J., editor
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- 1998
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26. Situaciones especiales en el tratamiento de la enfermedad diverticular: enfermedad multifocal, divertículo gigante, diverticulitis en colon derecho y diverticulitis en pacientes inmunosuprimidos
- Abstract
Diverticular disease is the most common benign pathology of the colon. It is considered a chronic disease with a variety in its abdominal symptoms where the main manifestation is diverticulitis. The prevalence of diverticulitis has increased significantly in Western countries in recent decades and as a result the number of hospitalizations and surgical evaluations, because they can lead to complications such as bleeding, abscess, obstruction and intestinal perforation. The most frequent form of presentation is sigmoid diverticulitis in a normal immunological context. The therapeutic guidelines are well defined differentiating between complicated and uncomplicated diverticulitis. However, the purpose of this article is to review all those less common diverticulitis that may consider special circumstances and, in whose treatment, there is no clear protocol. These circumstances are multifocal disease, giant colonic diverticulum, right-sided diverticulitis, and finally diverticulitis in immunosuppressed patients., La enfermedad diverticular es la patología benigna más frecuente del colon. Se considera una entidad crónica con una variedad en su sintomatología abdominal cuya principal manifestación es la diverticulitis. Su prevalencia ha aumentado de forma significativa en los países occidentales en las últimas décadas y con ello el número de hospitalizaciones y valoraciones quirúrgicas, ya que pueden desembocar en complicaciones como la hemorragia, el absceso, la obstrucción y la perforación intestinal. La forma más frecuente de presentación es la diverticulitis sigmoidea en un contexto inmunológico normal, cuyas guías terapéuticas están bien definidas diferenciando entre diverticulitis complicadas y no complicadas. Sin embargo el propósito de este artículo es la revisión de todas aquellas diverticulitis menos usuales que pueden considerarse circunstancias especiales y en cuyo tratamiento no existe un protocolo tan establecido. Estas circunstancias serían la enfermedad multifocal, el divertículo colónico gigante, la diverticulitis del lado derecho y por último la diverticulitis en pacientes con inmunosupresión.
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- 2021
27. Reduced fecal short‐chain fatty acids in hispanic children with ulcerative colitis
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Sarah Rotondo-Trivette, Sonia Michail, Fengzhu Sun, Yihui Luan, Oliver Fiehn, and Beibei Wang
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Dietary Fiber ,Male ,medicine.medical_specialty ,short‐chain fatty acids ,Younger age ,Adolescent ,pediatrics ,Physiology ,Gastroenterology ,Butyric acid ,Feces ,chemistry.chemical_compound ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,QP1-981 ,Child ,Colonic disease ,ulcerative colitis ,chemistry.chemical_classification ,business.industry ,Incidence (epidemiology) ,Significant difference ,Fatty acid ,Original Articles ,Hispanic or Latino ,Fatty Acids, Volatile ,medicine.disease ,Los Angeles ,Ulcerative colitis ,Cross-Sectional Studies ,chemistry ,Original Article ,Colitis, Ulcerative ,Female ,business - Abstract
Background It is known that patients with ulcerative colitis (UC) have reduced numbers of short‐chain fatty acid (SCFA) producing bacteria and reduced SCFA concentration in feces. There is also evidence that Hispanic patients have increased incidence of UC and increased likelihood of developing disease at a younger age. To understand why this might be, we compared fiber intake and fecal SCFA concentrations in Hispanic children with UC and non‐Hispanic children with UC. Methods In this cross‐sectional study conducted at the Children's Hospital of Los Angeles, stool was collected from 22 Hispanic and 31 non‐Hispanic children with UC. SCFAs in the stool were quantified using mass spectrometry. Diet information was collected at the time of stool collection using food frequency questionnaires. Results Acetic acid, butyric acid, isovaleric acid, and propionic acid concentrations are significantly lower in Hispanic children with UC compared to age, gender, and disease activity matched non‐Hispanic children with UC (p, Hispanic children with ulcerative colitis have lower short chain fatty acids.
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- 2021
28. Incorporating inulin and chitosan in alginate-based microspheres for targeted delivery and release of quercetin to colon.
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Liu, Siyao, Fang, Zhongxiang, and Ng, Ken
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INULIN , *QUERCETIN , *ALGINATES , *CHITOSAN , *MICROSPHERES , *COLON (Anatomy) , *FECES , *POLYMER networks - Abstract
[Display omitted] • Adding inulin and chitosan increased encapsulation efficiency of microspheres. • Alginate-inulin-chitosan microspheres delivered >80 % quercetin to colon. • The microspheres delayed release of quercetin under fecal microbiota degradation. Colon targeted delivery of quercetin by encapsulation has the potential to manage colonic diseases due to quercetin's pharmacological effects. To strengthen the functionalities of commonly used alginate microspheres for quercetin encapsulation, inulin was added as filling material and chitosan as coating material. Empty/quercetin-loaded alginate (AL-E/Q), alginate + inulin (ALIN-E/Q), alginate + inulin + chitosan (ALINCH-E/Q) microspheres were fabricated, with particle sizes ranging from 25.1 ± 1.8 to 79.4 ± 4.5 µm. All the formulated microspheres were negatively charged, and zeta potential was dependent mainly on chitosan coating and the pH of surrounding media. FTIR spectra of the microspheres suggested successful encapsulation of quercetin, formation of chitosan coating and potential hydrogen bonding between inulin and alginate. Scanning electron micrographs showed that inulin filling enhanced gel strength by filling up the pores in the alginate polymer network, and that loading of quercetin also helped to fill up the pores compared to empty microspheres. Combination of inulin as filling material and chitosan as coating material in quercetin loaded ALINCH-Q achieved superior performance compared to other formulations with encapsulation efficiency of 53.2 ± 1.2 %, and retention rate of the loaded quercetin up to 80.3 ± 4.4 % through in vitro gastrointestinal digestion, thus was chosen for colonic fermentation. Subjecting ALINCH-Q to colonic fermentation using pig fecal material as microbiota source showed that quercetin release was delayed but occurred within 3 h of fermentation and was completely metabolized by the microbiota by 24 h. Thus, ALINCH-Q microsphere showed potential in targeted delivery and release of quercetin to the colon. [ABSTRACT FROM AUTHOR]
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- 2022
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29. Tradução e adaptação cultural para o português do instrumento 'The Bowel Disease Questionnaire', utilizado para a avaliação de doenças gastrointestinais funcionais Portuguese-language cultural adaptation and translation of 'The Bowel Disease Questionnaire' used to assess functional bowel disorders
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Mariana Tschoepke Aires and Guilherme Loureiro Werneck
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Enteropatias ,Doenças funcionais do cólon ,Dispepsia ,Saúde do adolescente ,Questionários ,Validade ,Intestinal diseases ,Colonic disease ,Dyspepsia ,Teen health ,Questionnaires ,Validity ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
RACIONAL: As doenças gastrointestinais funcionais são reconhecidas como um problema de saúde pública e sua prevalência é pouco estudada no nosso meio. Em 1989, pesquisadores da Mayo Clinic elaboraram e validaram um questionário para a avaliação das doenças gastrointestinais funcionais denominado "The Bowel Disease Questionnaire". Apesar de ter sido utilizado em diferentes populações, sua aplicação em um contexto sociocultural diferente daquele para o qual foi desenvolvido, necessita de prévia adaptação para garantir a qualidade das informações a serem captadas. OBJETIVO: Realizar a tradução e a adaptação cultural do "The Bowel Disease Questionnaire" para o português com a finalidade de aplicação a uma população de adolescentes do Rio de Janeiro. MÉTODOS: Foram avaliadas as equivalências conceitual e de itens através de revisão bibliográfica e de reuniões com especialistas. A avaliação da igualdade semântica constou de julgamento acerca das equivalências de significado referencial e geral entre a retradução e o original e entre esta e a edição em português, respectivamente. A equivalência de mensuração foi avaliada através da confiabilidade e da consistência interna. RESULTADOS: Os conceitos abarcados pelo questionário original foram considerados pertinentes no nosso meio. O significado geral e referencial das palavras/termos se manteve na maioria das questões. A confiabilidade variou de razoável a quase perfeita, enquanto os grupos de questões referentes às doenças gastrointestinais funcionais mostraram consistência interna variando de 0,66 a 0,74. CONCLUSÃO: A versão em português do "The Bowel Disease Questionnaire" parece ser semântica e de conceito equivalente ao original e avaliar adequadamente as doenças gastrointestinais funcionais. O instrumento resultante da adaptação pode ser útil para avaliar as doenças gastrointestinais funcionais em populações de adolescentes no contexto brasileiro.BACKGROUND: Functional bowel disorders are considered a public health problem, but there are a few prevalence studies in Brazil. In 1999, researchers from the Mayo Clinic developed The Bowel Disease Questionnaire with the purpose to evaluate functional bowel disorders. Although this has been used in different studies and population, it is often necessary to perform a cultural adaptation of a questionnaire developed for use in another culture, in order to improve the quality of the information obtained. OBJECTIVE: To translate and adapt the Bowel Disease Questionnaire to Portuguese for its use in adolescents. METHODS: Assessment of conceptual and item equivalence involved evaluation of the pertinence of the concepts in the Brazilian context; translation was evaluated through semantic equivalence between the original instrument and the Portuguese version; measurement equivalence between the original and the Portuguese version was assessed by the intra-observer reliability and internal consistency. RESULTS: The Bowel Disease Questionnaire's concepts were considered pertinent in the Brazilian context; the semantic equivalence between the original and the Portuguese version were high; reliability ranged from moderate to almost perfect; internal consistency of the scales ranged from 0,66 to 0,74. CONCLUSION: The Portuguese version of the Bowel Disease Questionnaire seems to be semantically and culturally equivalent to the original version and might be useful for measuring functional bowel disorders among Brazilian adolescents.
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- 2006
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30. Sonography of Gastrointestinal Tract Diseases.
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Ahn, Sung Eun, Moon, Sung Kyoung, Lee, Dong Ho, Park, Seong Jin, Lim, Joo Won, Kim, Hyun Cheol, and Lee, Han Na
- Abstract
Sonographic evaluation of the gastrointestinal (GI) tract may be difficult because of overlying intraluminal bowel gas and gas‐related artifacts. However, in the absence of these factors and with the development of high‐resolution scanners and the technical experience of radiologists, sonography can become a powerful tool for GI tract assessment. This pictorial essay focuses on sonographic findings of GI tract lesions compared with endoscopic, computed tomographic, and magnetic resonance imaging findings. Neoplastic and non‐neoplastic diseases and postoperative complications are illustrated, and the distinctive sonographic characteristics of these entities are highlighted. [ABSTRACT FROM AUTHOR]
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- 2016
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31. The association between the increased performance of laparoscopic colon surgery and a reduced risk of surgical site infection
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Toshinori Ito, Shogo Kobayashi, Tsunekazu Mizushima, Makoto Yamasaki, Hiroki Fukunaga, Koji Umeshita, Atsushi Miyamoto, Yuichiro Doki, Daisaku Yamada, Junzo Shimizu, Mitsunobu Imazato, Yoshinori Kagawa, Kazuo Yamabe, and Masaki Mori
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Laparoscopic surgery ,Adult ,Male ,Risk ,medicine.medical_specialty ,Reduced risk ,Multivariate analysis ,Adolescent ,Colon ,medicine.medical_treatment ,Endoscopy, Gastrointestinal ,03 medical and health sciences ,Colonic Diseases ,Young Adult ,0302 clinical medicine ,Colon surgery ,Colorectal surgery ,Medicine ,Humans ,Surgical Wound Infection ,Colonic disease ,Aged ,Retrospective Studies ,Aged, 80 and over ,Analysis of Variance ,Cross Infection ,business.industry ,Open surgery ,General Medicine ,Middle Aged ,University hospital ,Surgery ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Original Article ,Female ,Laparoscopy ,business ,Surgical site infection - Abstract
Purpose Surgical site infection (SSI) is the most frequently occurring nosocomial infection. Remarkable surgical progress has recently been made in laparoscopic surgery. Therefore, our objective was to investigate the association between increased rates of laparoscopic colon surgery and SSI. Methods We retrospectively investigated SSI surveillance data from July 2003 to December 2015. Two university hospitals and 25 university-affiliated hospitals participated in prospective SSI surveillance. Univariate and multivariate analyses were performed to detect significant associations. Results We investigated 9655 colon surgeries. The year in which surgery was performed was significantly associated with the SSI rate (p = 0.0381). The rate of laparoscopic surgery gradually increased during the study period, and by 2012 it was routinely used for > 50% of colon surgeries. Laparoscopic surgery became a significant factor associated with reduced SSI rates compared with conventional open surgery once the performance rate of laparoscopic surgery reached > 50%. Conclusions Increasing rates of laparoscopic colon surgery tended to be associated with a reduction in the SSI risk after surgical treatment of colonic disease. The results of this study might encourage surgeons to view laparoscopic surgical techniques as an evidence-based approach for reducing the risk of SSI. Electronic supplementary material The online version of this article (10.1007/s00595-019-1760-1) contains supplementary material, which is available to authorized users.
- Published
- 2019
32. Report from 'Virtually Vilnius': the 15th Scientific and Annual Conference of the European Society of Coloproctology, 21-23 September 2020
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Gloria Zaffaroni, Rohan R Gujjuri, Zoe Garoufalia, Vittoria Bellato, Cristián Gallardo, Miguel Cunha, Richard R. W. Brady, Gianluca Pellino, Pellino, Gianluca, Bellato, Vittoria, Cunha, Miguel, Gallardo, Cristián, Garoufalia, Zoe, Gujjuri, Rohan, Zaffaroni, Gloria, and Brady, Richard R W
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Colonic Diseases ,Colonic Disease ,Rectal Diseases ,business.industry ,Gastroenterology ,Humans ,Library science ,Medicine ,business ,Human - Published
- 2021
33. The optimal use of colon capsule endoscopes in clinical practice.
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Bjørsum-Meyer T, Koulaouzidis A, and Baatrup G
- Abstract
Colon capsule endoscopy (CCE) has been available for nearly two decades but has grappled with being an equal diagnostic alternative to optical colonoscopy (OC). Due to the COVID-19 pandemic, CCE has gained more foothold in clinical practice. In this cutting-edge review, we aim to present the existing knowledge on the pros and cons of CCE and discuss whether the modality is ready for a larger roll-out in clinical settings. We have included clinical trials and reviews with the most significant impact on the current position of CCE in clinical practice and discuss the challenges that persist and how they could be addressed to make CCE a more sustainable imaging modality with an adenoma detection rate equal to OC and a low re-investigation rate by a proper preselection of suitable populations. CCE is embedded with a very low risk of severe complications and can be performed in the patient's home as a pain-free procedure. The diagnostic accuracy is found to be equal to OC. However, a significant drawback is low completion rates eliciting a high re-investigation rate. Furthermore, the bowel preparation before CCE is extensive due to the high demand for clean mucosa. CCE is currently not suitable for large-scale implementation in clinical practice mainly due to high re-investigation rates. By a better preselection before CCE and the implantation of artificial intelligence for picture and video analysis, CCE could be the alternative to OC needed to move away from in-hospital services and relieve long-waiting lists for OC., Competing Interests: The authors declared the following potential conflicts of interest with respect to the research, authorship and publication, or both, of this article: Thomas Bjørsum-Meyer has participated in advisory board meetings for Medtronic. Anastasios Koulaouzidis is consultant for Jinshan. He is director of iCERV Ltd. and cofounder of AJM Medicaps Ltd. He has received a GivenImaging Ltd-ESGE grant and material support for clinical research from SynMed/Intromedic. In the past 10 years, he has received honoraria and lecture fees from Jinshan, Dr FalkPharma UK and Ferring. He has also received educational travel support from Aquilant, Jinshan, Dr FalkPharma, Almirall and Ferring, and has participated in advisory board meetings for Tillots, Ankon and Dr FalkPharmaUK., (© The Author(s), 2022.)
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- 2022
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34. Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease?
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Sadaf Bhayat, Anay Kulkarni, Iona Ashworth, Chandrasen K. Sinha, and Sarah Martin
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medicine.medical_specialty ,medicine.medical_treatment ,lcsh:Surgery ,Gastroenterology ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Laparotomy ,Internal medicine ,medicine ,Small bowel disease ,Colonic disease ,business.industry ,lcsh:RJ1-570 ,lcsh:Pediatrics ,lcsh:RD1-811 ,medicine.disease ,digestive system diseases ,Parenteral nutrition ,Pediatrics, Perinatology and Child Health ,Necrotizing enterocolitis ,Cohort ,Gestation ,030211 gastroenterology & hepatology ,Surgery ,business - Abstract
BackgroundThe primary aim was to scrutinize our hypothesis: “Do more mature preterm (MMP) babies with surgical necrotizing enterocolitis (NEC) predominantly develop the colonic disease and are different in their response and behaviour in comparison to exceedingly preterm (EP) babies?” Secondary outcomes were to define time taken in developing NEC, time from diagnosis to laparotomy, requirement of parenteral nutrition (PN), and ventilatory support.MethodsWe defined MMP babies as ≥30 weeks of gestation and EP babies as ≤29 weeks+6 days of gestation. Inclusion criteria were all babies ResultsOf the total, 41% (97/234) of babies underwent laparotomy between 2010 and 2019. Totally, 81% were EP and 19% were MMP babies. Pure colonic involvement was seen in 9% of EP babies in comparison to 56% in the MMP babies (p=0.0001). Involvement of only the small bowel was seen in two-thirds of EP babies in comparison to only one-third in MMP babies (p=0.01). EP cohort required PN for 82 days (median) in comparison to 17 days (median) in the MMP cohort (p=0.001). Ventilation requirement in the EP group versus the MMP group was 24 vs 9 days (median), respectively (p=0.0006).ConclusionsMMP babies predominantly developed colonic disease, whereas EP babies predominantly developed small bowel disease. EP babies required a longer duration of PN and ventilation support. This study opens a new area of research to differentiate pathogenesis and maturation patterns of the small and large bowels in babies with NEC.
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- 2020
35. P083 High prevalence of ulcerative appendicitis in UC patients without colonic disease activity
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L Heuthorst, G. D'Haens, Christianne J. Buskens, W. A. Bemelman, Aart Mookhoek, and Manon E. Wildenberg
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medicine.medical_specialty ,Pancolitis ,High prevalence ,medicine.diagnostic_test ,Colorectal cancer ,business.industry ,Gastroenterology ,General Medicine ,medicine.disease ,Appendicitis ,Endoscopy ,Internal medicine ,Colonic Diseases ,medicine ,medicine.symptom ,business ,Colonic disease ,Proctitis - Abstract
Background The aim of the current study was to assess histological features of appendices from patients with UC and its clinical relevance. Methods Patients with UC in remission and active UC (therapy refractory) that underwent an appendectomy in the frame of clinical trials between 2012–2019 were included. Histological features of UC appendices were compared to those of patients with acute appendicitis and colon carcinoma. The Robarts Histopathology Index score (RHI) was used to assess appendiceal inflammation. In patients with active UC, clinical and histological characteristics were compared between patients with and without endoscopic response after appendectomy. Results In total, 140 appendix specimens were assessed (n=35 UC remission, n=35 active UC, n=35 acute appendicitis, n=35 colon carcinoma). Histological features of appendices from UC patients looked like UC rather than acute appendicitis. The incidence of active appendiceal inflammation was not different between UC patients in remission versus active disease (53.7% versus 46.3%, p=0.45) and limited versus extensive disease (58.5% versus 41.5%, p=0.50). Endoscopic response, assessed in 28 therapy refractory patients, was more frequently seen in patients with higher RHI scores (RHI>9 81.8% versus RHI≤9 9.1%, p=0.004) and limited disease (proctitis/left sided 63.6% versus pancolitis 36.4%, p=0.02). Conclusion The presence of active appendiceal inflammation is common in UC and not related to disease activity in the colon. More than 50% of UC patients in remission show active histological disease in the appendix. Favorable response to appendectomy for refractory UC was seen in cases with ulcerative appendicitis. These findings might support the role of the appendix as a driving force in UC.
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- 2021
36. Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
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Hiroaki Ikematsu, Kensuke Shinmura, Tomohiro Kadota, Tomonori Yano, Yusuke Yoda, Tatsunori Minamide, Tatsuro Murano, Keisuke Hori, and Masaaki Ito
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Male ,medicine.medical_specialty ,Colorectal cancer ,Science ,Comorbidity ,Article ,Resection ,Neoplasms, Multiple Primary ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Cumulative incidence ,In patient ,Neoplasm Invasiveness ,Significant risk ,Colonic disease ,Colectomy ,Aged ,Retrospective Studies ,Cancer ,Multidisciplinary ,Mucous Membrane ,business.industry ,Incidence (epidemiology) ,Incidence ,Neoplasms, Second Primary ,Colonoscopy ,Middle Aged ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Medicine ,030211 gastroenterology & hepatology ,Female ,Neoplasm Recurrence, Local ,business ,Colorectal Neoplasms ,Rectal disease - Abstract
Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.
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- 2020
37. Appropriate use of colonoscopy in Nigeria: a retrospective study using the American Society of Gastrointestinal Endoscopy (ASGE) 2012 guidelines
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Emuobor Odeghe, Aderemi Oluyemi, and Oluwafunmilayo Funke Adeniyi
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medicine.medical_specialty ,Chronic constipation ,medicine.diagnostic_test ,business.industry ,General surgery ,Colonoscopy ,Retrospective cohort study ,Appropriate use ,Abdominal mass ,Endoscopy ,Medicine ,medicine.symptom ,business ,Colonic disease ,Gastrointestinal endoscopy - Abstract
INTRODUCTION: Colonoscopy is the standard investigation for assessing colonic disease, with moderate yield. The American Society for Gastrointestinal Endoscopy (ASGE) published guidelines to tailor the appropriate use of colonoscopy. The aims of this study were to determine the frequency at which colonoscopy was performed for an appropriate indication based on ASGE´s 2012 guidelines, and to determine if there was an association of appropriateness of indication with endoscopic findings. METHODS: a retrospective study of colonoscopies performed in a private endoscopy centre in Lagos, Nigeria, between January 2014 and December 2016. Ethical approval was obtained before commencement. Data retrieved were basic demographics, indication of, and findings at colonoscopy. Data were analysed using SPSS 23. A p-value of
- Published
- 2020
38. Neonatal Small Left Colon Syndrome
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Ahmed H. Al-Salem
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medicine.medical_specialty ,Neonatal small left colon syndrome ,business.industry ,Small left colon syndrome ,medicine.disease ,Gastroenterology ,Surgery ,Left colon ,Internal medicine ,Recien nacido ,medicine ,business ,Hirschsprung's disease ,Colonic disease - Abstract
Neonatal small left colon syndrome is a rare cause of intestinal obstruction in the newborns. This is a report of 4 cases outlining aspects of diagnosis and treatment.
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- 2020
39. Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System
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Seung Won Hwang and Jae Sup Shin
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food.ingredient ,Article Subject ,Polymers and Plastics ,Pectin ,macromolecular substances ,02 engineering and technology ,lcsh:Chemical technology ,010402 general chemistry ,01 natural sciences ,Chitosan ,chemistry.chemical_compound ,food ,lcsh:TP1-1185 ,Pectinase ,Colonic disease ,Chromatography ,digestive, oral, and skin physiology ,technology, industry, and agriculture ,food and beverages ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,carbohydrates (lipids) ,chemistry ,Drug delivery ,Curcumin ,Drug release ,0210 nano-technology - Abstract
Curcumin-loaded chitosan-pectin microparticles based on polymeric microencapsulation were prepared by two methods to delay the release of curcumin in the digestive system, employing Mg2+ as a pectin-crosslinking agent for the first time. Pectin-coated curcumin-chitosan microparticles (C-g-PMg) and curcumin-loaded chitosan-pectin composite microparticles (C-PMg-g) were formulated, and their release profiles at pH 1.2 and at pH 6.8 were tested. The former (C-g-PMg) showed slower curcumin release profiles than the latter (C-PMg-g) because the C-g-PMg are composed of two layers, a chitosan-glutaraldehyde layer and a pectin-Mg2+ layer, which together hold the curcumin for a longer duration. Of the pectin-coated microparticles, those crosslinked with Mg2+ showed a slower release rate than those crosslinked with Ca2+, but the former showed a faster release rate at pH 6.8 in the presence of pectinase, acting as a promising drug delivery carrier for treating a colonic disease. The pectin layer and the pectin-crosslinking agent play a vital role in prolonging the release of curcumin until pectin is degraded by pectinase.
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- 2018
40. The DICA Endoscopic Classification for Diverticular Disease of the Colon Shows a Significant Interobserver Agreement among Community Endoscopists: an International Study
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Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G. A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D. L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P. G., Maconi G., Malfertheiner P., Mazzarri A., Mearin F., Milosavljevic T., Nardone G., de Oliveira E. C., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L. L., Walker M. M. D., Allegretta L., Altavilla N., Amaro P., Annunziata M. L., Barberio F., Basile G., Bedogni G., Belfiori V., Benvenuti S., Bertolami C., Bisello M., El Dammak M. B., Bozzi R., Buono M., Cambie G., Capezzuto E., Casamassima C., Chavoushian A., Ciofani R., Citarella C., Compare D., Cotruta B., D'amico F., Dulk M. D., Dyrda B. E., Festa V., Gallina S., Grasso R., Hanzel J., Taieb J. M., Lai M. A., Latella G., Lisi D., Lodi L., Marangi S., Mardegan A., Marlicz W., Maurano A., Milazzo G., Militaru V., Miraglia S., Monica F., Moskalev A., Natale A., Nicolas C., Pancetti A., Penna A., Pepe A. S., Pisano M., Pontone S., Prati M., Prisco A., Rando L., Hernandez E. R., Rosati O., Rossi G., Passoni G. R., Papa V., Nesme N. S., Schiffino L., Schillaci D., Selvaggi G., Taborchi F., Tornar A., Trebuna F., Triggiani C., Testai F. V., Vassallo R., Violi A., Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, A., Biondo, S., Cassieri, C., Crucitti, A., Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzarri, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, A., Papagrigoriadis, S., Pera, M., Persiani, R., Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Walker, M. M. D., Allegretta, L., Altavilla, N., Amaro, P., Annunziata, M. L., Barberio, F., Basile, G., Bedogni, G., Belfiori, V., Benvenuti, S., Bertolami, C., Bisello, M., El Dammak, M. B., Bozzi, R., Buono, M., Cambie, G., Capezzuto, E., Casamassima, C., Chavoushian, A., Ciofani, R., Citarella, C., Compare, D., Cotruta, B., D'Amico, F., Dulk, M. D., Dyrda, B. E., Festa, V., Gallina, S., Grasso, R., Hanzel, J., Taieb, J. M., Lai, M. A., Latella, G., Lisi, D., Lodi, L., Marangi, S., Mardegan, A., Marlicz, W., Maurano, A., Milazzo, G., Militaru, V., Miraglia, S., Monica, F., Moskalev, A., Natale, A., Nicolas, C., Pancetti, A., Penna, A., Pepe, A. S., Pisano, M., Pontone, S., Prati, M., Prisco, A., Rando, L., Hernandez, E. R., Rosati, O., Rossi, G., Passoni, G. R., Papa, V., Nesme, N. S., Schiffino, L., Schillaci, D., Selvaggi, G., Taborchi, F., Tornar, A., Trebuna, F., Triggiani, C., Testai, F. V., Vassallo, R., Violi, A., Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G.A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D.L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P.G., Maconi G., Malfertheiner P., Mazzari A., Mearin F., Milosavljevic T., Nardone G., Chavez De Oliveira E., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L.L., and Walker M.M.
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BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Diverticular Disease ,Endoscopic classification ,Video Recording ,Colonoscopy ,Gastroenterology ,Severity of Illness Index ,endoscopic classification ,Diverticulum ,classification ,complications ,Diverticular diseases ,Endoscopy ,methods ,Colonic Diseases ,0302 clinical medicine ,Community Health Services ,Community Health Service ,Observer Variation ,0303 health sciences ,medicine.diagnostic_test ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,agreement − colonoscopy − community setting − diverticular disease of the colon− endoscopic classification ,3. Good health ,Diverticulosis ,Malalties del còlon ,Diverticular disease of the colon ,Diverticular disease ,616.344-007.64 [udc] ,Community setting ,030211 gastroenterology & hepatology ,Human ,medicine.medical_specialty ,Scoring system ,Colonic Disease ,Settore MED/12 - GASTROENTEROLOGIA ,Reproducibility of Result ,agreement ,colonoscopy ,community setting ,diverticular disease of the colon ,Agreement ,03 medical and health sciences ,Internal medicine ,Severity of illness ,medicine ,Diverticulosis, Colonic ,Humans ,Colonic diseases ,030304 developmental biology ,Diverticular Diseases ,business.industry ,Colonoscòpia ,Reproducibility of Results ,medicine.disease ,Inter-rater reliability ,business ,Kappa - Abstract
Background and Aims: The Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification of diverticulosis and diverticular disease (DD) is currently available. It scores severity of the disease as DICA 1, DICA 2 and DICA 3. Our aim was to assess the agreement on this classification in an international endoscopists community setting. Methods: A total of 96 doctors (82.9% endoscopists) independently scored a set of DD endoscopic videos. The percentages of overall agreement on DICA score and a free-marginal multirater kappa (κ) coefficient were reported as statistical measures of interrater agreement. Results: Overall agreement in using DICA was 91.8% with a free-marginal kappa of 88% (95% CI 80-95). The overall agreement levels were: DICA 1, 85.2%; DICA 2, 96.5%; DICA 3, 99.5%. The free marginal κ was: DICA 1 = 0.753, DICA 2 = 0.958, DICA 3 = 0.919. The agreement about the main endoscopic items was 83.4% (k 67%) for diverticular extension, 62.6% (k 65%) for number of diverticula for each district, 86.8% (k 82%) for presence of inflammation, and 98.5 (k 98%) for presence of complications. Conclusions: The overall interrater agreement in this study ranges from good to very good. DICA score is a simple and reproducible endoscopic scoring system for diverticulosis and DD.
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- 2019
41. Diverticular disease: new perspectives in diet-therapeutic treatment
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Yáñez B, Edson, Maturana D, Javier, and Briones S, Lautaro
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Inflammation ,Enfermedad colónica ,Inflamación ,Fibra dietética ,digestive, oral, and skin physiology ,Enfermedad diverticular ,Colonic disease ,Dietary fiber ,Diverticular disease ,Diverticulitis - Abstract
RESUMEN La enfermedad diverticular corresponde a una condición habitual en el territorio occidental, siendo el hallazgo más frecuente en población de zonas urbanizadas. Respecto a su origen, se ha planteado la influencia de factores ambientales y genéticos, incluyendo en su etiología una inadecuada ingesta de fibra dietética, disbiosis de la microbiota intestinal y niveles alterados de vitamina D. A su vez, la enfermedad diverticular sintomática no complicada (EDNC) corresponde a un tipo de diverticulosis crónica cuyas características asemejan al síndrome de intestino irritable, lo que resalta la importancia en la comprensión de esta condición. Recientemente, se ha discutido la forma en que se aborda la enfermedad diverticular y en el siguiente escrito se expondrá evidencia sobre la patogénesis y su actual manejo. ABSTRACT Diverticular disease corresponds to a habitual condition in the western territory, being frequently found among the population of urban areas. Regarding its origin, the influence of environmental and genetic factors, including the etiology of dietary fiber intake, intestinal microbiota dysbiosis and altered levels of vitamin D have been recognized. Symptomatic uncomplicated diverticular disease corresponds to a type of chronic diverticulosis whose characteristics resemble irritable bowel syndrome, highlighting the importance of understanding this condition. Recently, the treatment of the disease has been discussed and the following review presents evidence on pathogenesis and its management.
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- 2019
42. Gated Mesoporous Silica Nanocarriers for a 'Two-Step' Targeted System to Colonic Tissue
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Isabel Lozoya-Agullo, Carmen Coll, Marta González-Álvarez, Elena Aznar, Cristina Giménez, Isabel González-Álvarez, Marival Bermejo, Félix Sancenón, M. Carmen Martínez-Bisbal, and Ramón Martínez-Máñez
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Male ,Pharmaceutical Science ,02 engineering and technology ,Colon targeting ,01 natural sciences ,gated materials ,Cell membrane ,chemistry.chemical_compound ,QUIMICA ORGANICA ,CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA ,Drug Discovery ,Tissue Distribution ,Intestinal Mucosa ,Drug Carriers ,Antibiotics, Antineoplastic ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,medicine.anatomical_structure ,Models, Animal ,Drug delivery ,Molecular Medicine ,Colonic disease ,0210 nano-technology ,Porosity ,Biocompatibility ,Cell Survival ,Colon ,Mesoporous silica nanoparticles ,Drug Compounding ,Nanotechnology ,010402 general chemistry ,Endocytosis ,colonic disease ,Polymethacrylic Acids ,Safranin ,QUIMICA ANALITICA ,medicine ,Animals ,Humans ,Gated materials ,mesoporous silica nanoparticles ,colon targeting ,QUIMICA INORGANICA ,Mesoporous silica ,Rats ,0104 chemical sciences ,chemistry ,Targeted drug delivery ,Doxorubicin ,Delayed-Action Preparations ,drug delivery ,Biophysics ,Nanoparticles ,Phenazines ,Caco-2 Cells ,Nanocarriers - Abstract
[EN] Colon targeted drug delivery is highly relevant not only to treat colonic local diseases but also for systemic therapies. Mesoporous silica nanoparticles (MSNs) have been demonstrated as useful systems for controlled drug release given their biocompatibility and the possibility of designing gated systems able to release cargo only upon the presence of certain stimuli. We report herein the preparation of three gated MSNs able to deliver their cargo triggered by different stimuli (redox ambient (S1), enzymatic hydrolysis (S2), and a surfactant or being in contact with cell membrane (S3)) and their performance in solution and in vitro with Caco-2 cells. Safranin O dye was used as a model drug to track cargo fate. Studies of cargo permeability in Caco-2 monolayers demonstrated that intracellular safranin O levels were significantly higher in Caco-2 monolayers when using MSNs compared to those of free dye. Internalization assays indicated that S2 nanoparticles were taken up by cells via endocytosis. S2 nanoparticles were selected for in vivo tests in rats. For in vivo assays, capsules were filled with S2 nanoparticles and coated with Eudragit FS 30 D to target colon. The enteric coated capsule containing the MSNs was able to deliver S2 nanoparticles in colon tissue (first step), and then nanoparticles were able to deliver safranin O inside the colonic cells after the enzymatic stimuli (second step). This resulted in high levels of safranin O in colonic tissue combined with low dye levels in plasma and body tissues. The results suggested that this combination of enzyme-responsive gated MSNs and enteric coated capsules may improve the absorption of drugs in colon to treat local diseases with a reduction of systemic effects., The authors acknowledge the financial support from the Spanish Government (Projects MAT2015-64139-C4-1-R, SAF2016-78756 and AGL2015-70235-C2-2-R) and the Generalitat Valenciana (Project GVA/2014/13).
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- 2017
43. Transmural colonic ischemia: clinical features and computed tomography findings
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Alturkistany, Samira, Artho, Giovanni, Maheshwari, Sharad, Blaichman, Jason, Kao, Ellen, and Mesurolle, Benoît
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COLON diseases , *TOMOGRAPHY , *ISCHEMIA , *CLINICAL trials , *COLECTOMY , *MEDICAL imaging systems - Abstract
Abstract: Our purpose was to describe the computed tomography features of transmural colonic ischemia in correlation with clinical, laboratory and histopathological findings of 14 patients who underwent colectomy (9 female and 5 male; mean age, 68 years). Seven patients died (50%). Transmural necrosis involved the right colon in 10 patients (10/14, or 72%). Eleven patients showed thickened colonic wall (11/14, or 79%), 10 pneumatosis (10/14, or 71%), 5 gas in the portal venous system (5/14, or 36%), and 14 fat stranding (14/14, or 100%). [Copyright &y& Elsevier]
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- 2012
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44. Achieving quality in colonoscopy: bowel preparation timing and colon cleanliness.
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Athreya, Prasad J., Owen, Gareth N., Wong, Shing W., Douglas, Philip R., and Newstead, Graham L.
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COLONOSCOPY , *COLON cancer , *INTESTINAL diseases , *PATHOLOGY , *DIVERTICULUM , *CONSTIPATION - Abstract
Colonoscopy is considered the gold standard for investigation of large bowel pathology. Numerous factors influence the efficacy of bowel preparation for colonoscopy. Inadequate bowel preparation can lead to missed pathology. Timing of fasting and bowel preparation, timing of procedure and possibly patient bowel habit and presence of diverticula may have an influence on the quality of the preparation. The aim of this study was to investigate the quality of cleansing of sodium picosulfate (Picoprep-3™, Pharmatel Fresenius Kabi Pty Ltd, Pymble, NSW, Australia) with different administration schedules and to evaluate whether patient's bowel patterns influence the quality of cleansing. Three hundred twenty-five patients (175 morning and 150 afternoon procedures) were interviewed prior to colonoscopy to evaluate bowel habit and timing of preparation administration. Quality of cleansing was then assessed during colonoscopy using a 5-point scale. Further factors analysed included the patient's prior bowel habit and the presence of diverticula at colonoscopy. Procedural end points evaluated included procedure total time, caecal intubation time and withdrawal times. The quality of cleansing for individual bowel segments was worse for afternoon procedures ( P < 0.05 for some segments) and for patients with prior constipation ( P < 0.05 for descending colon segments). Caecal intubation times were shorter for patients with diarrhoea and longer for female patients, who also had shorter withdrawal times. No correlation was found between the procedural end points (total duration, caecal intubation time and withdrawal times) and the timing of fasting Quality of cleansing is significantly improved when bowel preparation is taken entirely the day prior to colonoscopy. Patients with prior constipation demonstrated poorer cleansing. [ABSTRACT FROM AUTHOR]
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- 2011
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45. Su498 SIMPLIFIED MAGNETIC RESONANCE INDEX OF ACTIVITY IS USEFUL FOR TERMINAL ILEAL BUT NOT COLONIC DISEASE IN CHILDREN WITH CROHN'S DISEASE
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Maua H. Mosha, Shanshan Bao, Jeffrey S. Hyams, Douglas Moote, and Chelsea A. Lepus
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Crohn's disease ,medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Magnetic resonance imaging ,medicine.disease ,Terminal (electronics) ,Internal medicine ,medicine ,business ,Colonic disease - Published
- 2021
46. Hartmann’s Colectomy and Reversal in Diverticulitis: A Population-Level Assessment.
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Salem, Leon, Anaya, Daniel A., Roberts, Kurt E., and Flum, David R.
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PURPOSE: This study was designed to assess the costs and outcomes of colostomy and colostomy reversal in patients with diverticulitis and examine the impact of such procedures on the health care system. METHODS: We employed a retrospective design and used a Washington State administrative database to identify patients undergoing operations with colostomy (1987-2002) who were followed over time. Descriptive and comparative analysis was performed, focusing on patients with diverticulitis. RESULTS: There were 16,556 patients who underwent colostomy and 5,420 (32.7 percent) were for diverticulitis and its related complications (mean age, 64.8 ± 15.1 years; 53.2 percent female). In patients with diverticulitis, the rate of colostomy reversal was 56.3 percent (80 percent in patients less than 50 years, and 30 percent in patients over 77 years). The in-hospital mortality rate after colostomy reversal was 0.36 percent, and was 2.6 percent in those over 77 years of age. After colostomy reversal a second stoma was used in 3.4 percent, re- operation was required for bleeding complications in 0.6 percent, and infectious complications were noted in 2 percent. The length of time from colostomy to its reversal was approximately five months (138.1 ± 164 days; interquartile range, 72-156). The relationship between the length of time from colostomy to reversal was evaluated and the adjusted odds of a second stoma being used at the time of colostomy reversal were 45 percent higher (odds ratio, 1.45; 95 percent confidence interval, 1.22, 1.73) for each increase in time interval (<3, 6-9, 9-12, >12 months). CONCLUSIONS: One-third of all colostoniles were related to diverticulitis and only 56 percent were reversed. We identified a higher than expected mortality rate among older patients undergoing colostomy reversal. The impact of colostomy and reversal operations on both patients and the health care system is significant. [ABSTRACT FROM AUTHOR]
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- 2005
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47. P084 Ileal gene expression changes are associated with colonic disease activity in patients with ulcerative colitis
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Maaike Vancamelbeke, G. Van Assche, Isabelle Cleynen, Severine Vermeire, Sare Verstockt, and Marc Ferrante
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medicine.medical_specialty ,business.industry ,Internal medicine ,Gene expression ,Gastroenterology ,Medicine ,In patient ,General Medicine ,business ,medicine.disease ,Ulcerative colitis ,Colonic disease - Published
- 2018
48. IDDF2019-ABS-0089 Hsa_circ_0053063 acts as a sponge of miR-361–3p in colon epithelial cells
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Hongzhi Xu, Jian-Lin Ren, Shaohui Tang, Wei Huang, and Ying Shi
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Reporter gene ,biology ,Chemistry ,Competing endogenous RNA ,Autophagy-related protein 13 ,biology.organism_classification ,Molecular biology ,Epithelium ,Sponge ,medicine.anatomical_structure ,microRNA ,medicine ,Target gene ,Colonic disease - Abstract
Background The dynamic changes of serum circRNAs, which act as a sponge of microRNA, has a great potential in predicting colonic disease, especially in malignant diseases. However, whether the mechanism of circRNA in regulating colonic epithelial mucosa is still unknown. Here, we explore the sponging effects of hsa_circ_0053063 targeting miR-361-3p in colon epithelial cells. Methods According to the ceRNA analysis, the potential target miRNAs of hsa_circ_0053063 were collected. Dual-luciferase reporter gene assays were performed to confirm the circRNA sponge of miRNAs. Then the potential target gene of miR-361-3p was predicted. Dual-luciferase reporter gene assays and real-time PCR were performed to detect the regulation between ncRNAs and target gene in colon epithelial cells HCoEpiC and NCM460. Results According to the ceRNA analysis, we found that miR-361-3p might be a target of hsa_circ_0053063 (figure 1a). Dual-luciferase reporter gene assays demonstrated that hsa_circ_0053063 bound miR-361-3p directly (figure 1b). Then we predicted that ATG13 was a target gene of miR-361-3p. Dual-luciferase reporter gene assays demonstrated that miR-361-3p bound ATG13 directly. Real-time PCR revealed that miR-361-3p decreased expression of ATG13, however, hsa_circ_0053063 reversed the inhibition of expression of ATG13 by miR-361-3p. Conclusions Hsa_circ_0053063 released the inhibition of expression of ATG13 by miR-361-3p. hsa_circ_0053063 may act as a sponge of miR-361-3p targeting ATG13 in colon epithelial cell.
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- 2019
49. PWE-060 CT colonograms in elderly patients, a safe and accurate colonic examination
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Ajay Verma, Bhavini Billimoria, Michael Adeleye, and Neel Raja
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,Gold standard ,Perforation (oil well) ,Colonoscopy ,medicine.disease ,digestive system diseases ,Polypectomy ,Endoscopy ,Internal medicine ,Medicine ,General hospital ,business ,Colonic disease - Abstract
Introduction In Kettering General Hospital (KGH) we perform almost 500 CT colonograms (CTCs) annually for patients who; do not want, are unable to tolerate, or have failed a colonoscopy (which is considered the “gold standard” colonic examination). The most common reasons for CTC are iron deficiency anaemia, and change in bowel habit, often with the aim of detecting colorectal cancer (CRC). We have seen an increase over time, in the use of CTC in elderly patients, as a first line investigation. With an ageing population, we explore the significance of performing this examination, in an elderly population who may not be suitable for further investigation/intervention. Methods We reviewed 1479 patients who had undergone a CT Colonogram between October 2015 and October 2018. Of these, we focused on patients aged ≥80 at the time of scanning. CTC reports were analysed and categorised into those with positive, indeterminate findings, and those with no significant findings. All patients ≥80 years old were followed up (via their electronic records) to observe their outcomes. Results 1479 patient underwent a CTC at KGH during the 3-year period. 454 patients were aged ≥80 years old (30.7%) – mean & median age 84, range 8–7. 69 patients had positive colonic findings (15.2% - see figure). Of which, 31 had CRC reported (14 operated straight away, 5 had endoscopy then surgery, 1 had endoscopy only (no tumour seen), 11 were not operated on). 22 had polyps reported (13 had endoscopy at which 12 had polypectomy, 9 did not have endoscopy). 16 had indeterminate findings (10 had endoscopy which nil significant found). Of the 385 patients who had CTCs with nil significant colonic findings, 9 had extra colonic tumours. At follow up (105 patients in 12 months from October 2015, 137 patients in 201–7, 143 patients in 201–8, range 0 – 36 months), none of the patients have been diagnosed with CRC thus far. Conclusion In this study, CT colonography was used in elderly patients aged ≥80 years old as a first or second line colonic examination. The yield of diagnosing colorectal cancer was 6.9% (31/454). CTC that reported negatively for colonic findings seems to protect patients for –6 months. Whilst colonoscopy may be the preferred diagnostic test for colonic disease, it is an invasive test with a small risk of perforation. CTC is safer, and better tolerated. The reports are generally accurate with regards to significant colonic findings, especially when diagnosing CRC. This study does confirm the safety and efficacy of CTC and suggests that it is an appropriate colonic investigation for elderly patients (aged ≥80 years old) first or second line.
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- 2019
50. SICE national survey: current status on the adoption of laparoscopic approach to the treatment of colorectal disease in italy
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Elmore, Ugo, Vignali, Andrea, Rosati, Riccardo, Valeri, Andrea, Silecchia, Gianfranco, Amisano, Marco, Anania, Gabriele, Andreone, Dario, Angelone, Giovanni, Baldazzi, Gianandrea, Bergamini, Carlo, Biondo, Francesco Giuseppe, Boni, Luigi, Brolese, Alberto, Brachet Contul, Riccardo, Campagnacci, Roberto, Campanile, Fabio, Cavicchi, Angelo, Carlini, Massimo, Cola, Bruno, Cesari, Maurizio, Covotta, Luca, Cumbo, Pietro, De Manzini, Nicolò, de Marchi, Francesco, de Paolis, Paolo, Ercolani, Giorgio, Fernando, Manes, Ferrero, Alessandro, Francioni, Gianfranco, Garulli, Gianluca, Genna, Michele, Gianesini, Raffaele, Gioffrè, Aldo, Guerrieri, Mario, Azzola Guicciardi, Marco, Jovine, Elio, Laterza, Ernesto, Merigliano, Stefano, Milone, Marco, Moretto, Gianluigi, Morpurgo, Emilio, Navarra, Giuseppe, Neri, Vincenzo, Ottonello, Roberto, Panebianco, Vincenzo, Pavanello, Maurizio, Personnettaz, Eraldo, Piccoli, Micaela, Priosa, Fabio, Rossi, Aldo, Sorrentino, Mario, Tedeschi, Umberto, Testa, Silvio, Verzelli, Augusto, Vettoretto, Nereo, Violi, Vincenzo, Zattini, Pier Sante, Elmore, Ugo, Vignali, Andrea, Rosati, Riccardo, Valeri, Andrea, Silecchia, Gianfranco, Ercolani Giorgio, Elmore, U., Vignali, A., Rosati, R., Valeri, A., Silecchia, G., Amisano, M., D'Anania, Olga, Andreone, D., Angelone, G., Baldazzi, G., Bergamini, Simone, Biondo, F. G., Boni, L., Brolese, A., Contul, R. B., Campagnacci, R., Campanile, F., Cavicchi, A., Carlini, M., Cola, B., Cesari, M., Covotta, L., Cumbo, P., De Manzini, N., de Marchi, F., de Paolis, V. P., Ercolani, G., Fernando, M., Ferrero, A., Francioni, G., Garulli, G., Genna, M., Gianesini, R., Gioffre, A., Guerrieri, M., Guicciardi, M. A., Jovine, E., Laterza, E., Merigliano, S., Milone, M., Moretto, G., Morpurgo, E., Navarra, G., Neri, V., Ottonello, R., Panebianco, V., Pavanello, M., Personnettaz, E., Piccoli, M., Priosa, F., Rossi, A., Sorrentino, M., Tedeschi, U., Testa, S., Verzelli, A., Vettoretto, Luciano, Violi, V., Zattini, P. S., Silecchia, Gianfranco, Amisano, Marco, Anania, Gabriele, Andreone, Dario, Angelone, Giovanni, Baldazzi, Gianandrea, Bergamini, Carlo, Biondo, Francesco Giuseppe, Boni, Luigi, Brolese, Alberto, Brachet Contul, Riccardo, Campagnacci, Roberto, Campanile, Fabio, Cavicchi, Angelo, Carlini, Massimo, Cola, Bruno, Cesari, Maurizio, Covotta, Luca, Cumbo, Pietro, De Manzini, Nicolò, de Marchi, Francesco, de Paolis, Paolo, Ercolani, Giorgio, Fernando, Mane, Ferrero, Alessandro, Francioni, Gianfranco, Garulli, Gianluca, Genna, Michele, Gianesini, Raffaele, Gioffrè, Aldo, Guerrieri, Mario, Azzola Guicciardi, Marco, Jovine, Elio, Laterza, Ernesto, Merigliano, Stefano, Milone, Marco, Moretto, Gianluigi, Morpurgo, Emilio, Navarra, Giuseppe, Neri, Vincenzo, Ottonello, Roberto, Panebianco, Vincenzo, Pavanello, Maurizio, Personnettaz, Eraldo, Piccoli, Micaela, Priosa, Fabio, Rossi, Aldo, Sorrentino, Mario, Tedeschi, Umberto, Testa, Silvio, Verzelli, Augusto, Vettoretto, Nereo, Violi, Vincenzo, and Zattini, Pier Sante
- Subjects
Colorectal cancer ,Endoscopic surgery ,Colorectal Neoplasm ,Endoscopy, Gastrointestinal ,Imaging ,Colonic Diseases ,0302 clinical medicine ,Computer-Assisted ,Surveys and Questionnaires ,Laparoscopy ,Survey ,Societies, Medical ,Colectomy ,International market ,medicine.diagnostic_test ,Rectal Disease ,3D technology ,Colorectal disease ,Surgery ,Colon ,Colorectal Neoplasms ,Humans ,Imaging, Three-Dimensional ,Italy ,Procedures and Techniques Utilization ,Rectal Diseases ,Rectum ,Surgery, Computer-Assisted ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Human ,medicine.medical_specialty ,Gastrointestinal ,Colonic Disease ,NO ,03 medical and health sciences ,Medical ,medicine ,Rectal resection ,Survey, Colorectal cancer, Surgery, Laparoscopy, 3D technology, Colorectal disease ,3D technology, Colorectal cancer, Colorectal disease ,Laparoscopy, Surgery, Survey ,Colectomy, Colon, Colonic Diseases, Colorectal Neoplasms, Endoscopy, Gastrointestinal, Humans, Imaging, Three-Dimensional, Italy, Laparoscopy, Procedures and Techniques Utilization, Rectal Diseases, Rectum, Societies, Medical, Surgery, Computer-Assisted, Surveys and Questionnaires ,business.industry ,General surgery ,Left colectomy ,Endoscopy ,medicine.disease ,Invasive surgery ,Three-Dimensional ,business ,Societies - Abstract
The real diffusion of laparoscopy for the treatment of colorectal diseases in Italy is largely unknown. The main purpose of the present study is to investigate among surgeons dedicated to minimally invasive surgery, the volume of laparoscopic colorectal procedures, the type of operation performed in comparison to traditional approach, the indication for surgery (benign and malignant) and to evaluate the different types of technologies used. A structured questionnaire was developed in collaboration with an international market research institute and the survey was published online; invitation to participate to the survey was issued among the members of the Italian Society of Endoscopic Surgery (SICE). 211 surgeons working in 57 surgical departments in Italy fulfilled and answered the online survey. A total of 6357 colorectal procedures were recorded during the year 2015 of which 4104 (64.1%) were performed using a minimally invasive approach. Colon and rectal cancer were the most common indications for laparoscopic approach (83.1%). Left colectomy was the operation most commonly performed (41.8%), while rectal resection accounted for 23.5% of the cases. Overall conversion rate was 5.9% (242/4104). Full HD standard technology was available and routinely used in all the responders' centers. The proportion of colorectal resections that are carried out laparoscopically in dedicated centers has now reached valuable levels with a low conversion rate.
- Published
- 2019
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