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4. Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort

Author

Duval, Xavier, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Tubiana, Sarah, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, Broucker, Thomas De, Levy Bruhl, Daniel, Raffi, François, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Lacassin, Flore, Lamaury, Isabelle, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cecile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean-Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Kerneis, Solen, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, Van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Coordination and statistical analyses, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, M.-K., Revest, M., Poyart, C., Martin-Blondel, G., Lecuit, M., Cua, E., Pasquet, B., Preau, M., Hoen, B., and Duval, X.

Published
2020
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8. Early-onset gout and rare deficient variants of the lactate dehydrogenase D gene.

Author

Bardin, Thomas, Ducrot, Yves-Marie, Nguyen, Quang, Letavernier, Emmanuel, Zaworski, Jeremy, Ea, Hang-Korng, Touzain, Fréderic, Do, Minh Duc, Colot, Julien, Barguil, Yann, Biron, Antoine, Resche-Rigon, Matthieu, Richette, Pascal, and Collet, Corinne

Subjects
GOUT diagnosis, HYPERURICEMIA, AFRICANS, MELANESIANS, SEQUENCE analysis, GENETIC mutation, HUMAN genome, GENETIC variation, LACTATE dehydrogenase, ENZYME-linked immunosorbent assay, DESCRIPTIVE statistics, RESEARCH funding, GOUT
Abstract

Objectives To investigate whether the lactate dehydrogenase D (LDHD) gene deficiency causes juvenile-onset gout. Methods We used whole-exome sequencing for two families and a targeted gene-sequencing panel for an isolated patient. d- lactate dosages were analysed using ELISA. Results We demonstrated linkage of juvenile-onset gout to homozygous carriage of three rare distinct LDHD variants in three different ethnicities. In a Melanesian family, the variant was (NM_153486.3: c.206C>T; rs1035398551) and, as compared with non-homozygotes, homozygotes had higher hyperuricaemia (P  = 0.02), lower fractional clearance of urate (P  = 0.002), and higher levels of d -lactate in blood (P  = 0.04) and urine (P  = 0.06). In a second, Vietnamese, family, very severe juvenile-onset gout was linked to homozygote carriage of an undescribed LDHD variant (NM_153486.3: c.1363dupG) leading to a frameshift followed by a stop codon, p.(AlaGly432fsTer58). Finally, a Moroccan man, with early-onset and high d -lactaturia, whose family was unavailable for testing, was homozygous for another rare LDHD variant [NM_153486.3: c.752C>T, p.(Thr251Met)]. Conclusion Rare, damaging LDHD variants can cause autosomal recessive early-onset gout, the diagnosis of which can be suspected by measuring high d -lactate levels in the blood and/or urine. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease

Author

Benadji, Amine, Danis, Kostas, Brieu, Nathalie, Gaillat, Jacques, Mourvillier, Bruno, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Bonacorsi, Stephane, Lecuit, Marc, Frachet, Bruno, Debroucker, Thomas, Levy Bruhl, Daniel, Preau, Marie, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Béraud, Guillaume, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Cambau, Emmanuelle, Camuset, Guillaume, Canevet, Christophe, Caron, François, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Duval, Xavier, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Caroline, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gravet, Alain, Gregoire-Faucher, Valérie, Grosset, Marine, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Hoen, Bruno, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Kerneis, Solen, Lamaury, Isabelle, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Picot, Sandrine, Pierrejean, Denys, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Ploy, Marie-Cécile, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Poyart, Claire, Prazuck, Thierry, Quaesaet, Luc, Raffi, François, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cécile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, van Grunderbeeck, Nicolas, Vandenesch, François, Varon, Emmanuelle, Verdon, Renaud, Vergnaud, Michel, Vidal, Magali, Vittecoq, Daniel, Vuotto, Fanny, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, Sarah, Arsac, Philippe, Benoit, Martha, Bernard, Louis, Bissuel, François, Bret, Laurent, Brieu, Natalie, Burret, Jennifer, Carvalhoschneider, Claudia, Champagne, Hélène, Chapalain, Joséphine, Chardon, Hubert, Chavanet, Pascal, Ducruet, Judith, Epaulard, Olivier, Fabre, Marc, Fasquelle, Dominique, Forestier, Emmanuel, Galempoix, Jean-Marc, Gautier, Guillaume, de Curraize, Claire Goulard, Gracet, Alain, Gubavu, Camélia, Guinard, Jérôme, Habet, Tarik, Haudour, Aurélie, Henry, Caroline, Hombrouckalet, Cécile, Janssen, Céline, Kisteman, Jean-Paul, Lanotte, Philippe, Lartigue, Marie-Frédérique, Launois, Claire, Lebrun, Cécile, Legout, Laurence, Levast, Marion, Madoux, Yannick, Maulin, Laurence, Mestrallet, Stéphanie, Mohareb, Abdo, Mootien, Joy, Nguyen, Yohan, Noel, Franck, Ogielska, Maja, Ogier Desserrey, Agathe, Paleau, Anne, Pavel, Simona, Pechinot, André, Pelloux, Isabelle, Petillon, Camille, Petitprez, Hélène, Podac, Bianca, Poirot, Jerome, Ponceau, Bénédicte, Prieur, Nathalie, Recule, Christine, Saraceni, Orlando, Sartre, Jacques, Sifaoui, Farid, Simonin, Catherine, Strady, Christophe, Tellini, Charlotte, Texier, Anthony, Thouvenin, Maxime, Tixier, Anne, Tremeaux, Pauline, Verger, Pascale, Vernet-Garnier, Véronique, Verquin, Jean-Pierre, Vitrat, Virginie, Vray, Isabelle, Zamfir, Oana, Zucchini, Laure, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], CHI Créteil, Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), The COMBAT study was supported by the Assistance Publique Hopitaux de Paris, French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company, which also funded ORP. The study was endorsed by the following professional organizations: Association Pour l’enseignement de la Thérapeutique, Société de Pathologie Infectieuse de Langue Française, Société Française de Microbiologie, Société Nationale Française de Médecine Interne, Société de Réanimation de Langue Française, Société Française de Gérontologie, Société Française d’Anesthésie-Réanimation. The SIIP study was supported by (i) the Société de Pathologie Infectieuse de Langue Fran.aise (SPILF, the French Infectious Diseases Society), (ii) Santé Publique France (SpFrance, the French National Public Health Agency), (iii) the European Centre for Disease Prevention and Control (ECDC), and (iv) Pfizer. The Regional Observatories of Pneumococci (Observatoires Régionaux du Pneumocoque) were supported by Pfizer, BioMerieux, and Sanofi., and Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE)

Subjects
Adult, Microbiology (medical), Serotype, medicine.medical_specialty, Multivariate analysis, Adolescent, [SDV]Life Sciences [q-bio], 30-day mortality, Serogroup, medicine.disease_cause, Logistic regression, Pneumococcal Infections, Cohort Studies, Pneumococcal Vaccines, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Streptococcus pneumoniae, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Aged, 0303 health sciences, Meningitis, Pneumococcal, 030306 microbiology, business.industry, Mortality rate, Infant, Invasive pneumococcal disease, Pneumococcal vaccine, General Medicine, bacterial infections and mycoses, medicine.disease, 3. Good health, Infectious Diseases, business, Meningitis, Cohort study
Abstract

International audience; Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015.Methods: This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression.Results: Among the 771 enrolled patients (median age 66 years, IQR [52.0-79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines.Conclusion: We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients.Clinical trial: ClinicalTrial. Gov identification number: NCT01730690.

Published
2021
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15. MALDI-TOF MS: An effective tool for a global surveillance of dengue vector species

Author

Rakotonirina, Antsa, primary, Pol, Morgane, additional, Raharimalala, Fara Nantenaina, additional, Ballan, Valentine, additional, Kainiu, Malia, additional, Boyer, Sébastien, additional, Kilama, Sosiasi, additional, Marcombe, Sébastien, additional, Russet, Sylvie, additional, Barsac, Emilie, additional, Vineshwaran, Rama, additional, Selemago, Malia Kaleméli, additional, Jessop, Vincent, additional, Robic, Geneviève, additional, Girod, Romain, additional, Brey, Paul T., additional, Colot, Julien, additional, Dupont-Rouzeyrol, Myrielle, additional, Richard, Vincent, additional, and Pocquet, Nicolas, additional

Published
2022
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16. One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study

Author

Duval, Xavier, Taha, Muhamed-Kheir, Lamaury, Isabelle, Escaut, Lélia, Gueit, Isabelle, Manchon, Pauline, Tubiana, Sarah, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, de Broucker, Thomas, Bruhl, Daniel Levy, Raffi, François, Preau, Marie, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Pomares, Typhaine Billard, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Duval, Aurélien Dinh Xavier, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Caroline, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Kerneis, Solen, Lacassin, Flore, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Yoganaden, Joy Mootien, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Denys, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cécile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Infections Bactériennes Invasives - Invasive Bacterial Infections, Institut Pasteur [Paris] (IP), CHU Pointe-à-Pitre/Abymes [Guadeloupe], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Rouen, Normandie Université (NU), and This study was supported by funding from the Assistance Publique Hopitaux de Paris, the French Society of Infectious Diseases, Pfizer and Sanofi. The rapid service and open access fees were funded by Sanofi.

Subjects
Adult, Community-acquired bacterial meningitis, Adolescent, [SDV]Life Sciences [q-bio], General Medicine, Meningitis, Meningococcal, Meningococcal meningitis, Meningitis, Bacterial, Cohort Studies, Disease Progression, Quality of Life, Humans, Pharmacology (medical), Prospective Studies, France, Long-term follow-up
Abstract

Trial registration: ClinicalTrial.Gov identification number NCT01730690. the COMBAT study group; International audience; Introduction: COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year.Methods: Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis.Results: Five of the 111 patients with meningococcal meningitis died during initial hospitalisation and two died between discharge and 12 months, leaving 104 patients alive 1 year after enrolment, 71 of whom provided 12-month follow-up data. The median age was 30.0 years and 54.1% of the patients had no identified risk factor for meningitis. More than 30% reported persistent headache, more than 40% were not satisfied with their sleep and 10% had concentration difficulties. Hearing loss was present in about 15% of the patients and more than 30% had depressive symptoms. About 13% of the patients with a previous professional activity had not resumed work. On the SF-12 Health Survey, almost 50% and 30% had physical component or mental component scores lower than the 25th percentile of the score distribution in the French general population. There was a non-significant improvement in the patients' disability scores from hospital discharge to 12 months (p = 0.16), but about 10% of the patients had residual disability.Conclusions: Although most patients in our cohort survive meningococcal meningitis, the long-term burden is substantial and therefore it is important to ensure a prolonged follow-up of survivors and to promote preventive strategies, including vaccination.

Published
2022
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21. Flying Fox Hemolytic Fever, Description of a New Zoonosis Caused by Candidatus Mycoplasma haemohominis

Author

Descloux, Elodie, primary, Mediannikov, Oleg, additional, Gourinat, Ann-Claire, additional, Colot, Julien, additional, Chauvet, Martine, additional, Mermoud, Isabelle, additional, Desoutter, Denise, additional, Cazorla, Cécile, additional, Klement-Frutos, Elise, additional, Antonini, Luca, additional, Levasseur, Anthony, additional, Bossi, Vincent, additional, Davoust, Bernard, additional, Merlet, Audrey, additional, Goujart, Marie-Amélie, additional, Oedin, Malik, additional, Brescia, Fabrice, additional, Laumond, Sylvie, additional, Fournier, Pierre-Edouard, additional, and Raoult, Didier, additional

Published
2020
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23. Additional file 1 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Subjects
parasitic diseases
Abstract

Additional file 1: Figure S1. MALDI-TOF MS spectra of fresh mosquitoes and those harvested from BG-sentinel at each same point.

Published
2020
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24. Additional file 2 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Subjects
parasitic diseases
Abstract

Additional file 2: Figure S2. MSP dendrogram of all the mosquitoes included in the New Caledonian MALDI-TOF database (n = 67).

Published
2020
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25. Additional file 6 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Abstract

Additional file 6: Figure S6. Comparison of log-score values according to number of spots per sample.

Published
2020
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26. Additional file 5 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Abstract

Additional file 5: Figure S5. Comparison of LSVs of Ae. aegypti collected in 2015 and preserved for four years at − 80 °C (n = 20) and LSVs of Ae. aegypti collected in 2018 and analyzed no later than five months following sampling (n = 30).

Published
2020
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27. Additional file 4 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Abstract

Additional file 4: Figure S4. Impact of preservation duration on Ae. aegypti identification scores.

Published
2020
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28. Additional file 3 of MALDI-TOF MS: optimization for future uses in entomological surveillance and identification of mosquitoes from New Caledonia

Author

Rakotonirina, Antsa, Pol, Morgane, Kainiu, Malia, Barsac, Emilie, Tutagata, Jordan, Sosiasi Kilama, O’Connor, Olivia, Tarantola, Arnaud, Colot, Julien, Dupont-Rouzeyrol, Myrielle, Richard, Vincent, and Pocquet, Nicolas

Abstract

Additional file 3: Figure S3. ROC to determine the threshold value which maximizes the sensitivity and specificity of MALDI-TOF MS for mosquito species identification.

Published
2020
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29. A fusidic acid-resistant (PVL+) clone is associated with the increase in methicillin-resistant Staphylococcus aureusin New Caledonia

Author

Bourles, Alexandre, Tristan, Anne, Vandenesch, François, Bes, Michèle, Laurent, Frédéric, Ranc, Anne-Gaëlle, Kainiu, Malia, Gourinat, Ann-Claire, Biron, Antoine, Cazarola, Cécile, Goarant, Cyrille, and Colot, Julien

Abstract

•High prevalence of fusidic acid resistance in methicillin-resistant S. aureus•Dominance of community-acquired MRSA harbouring PVL toxin•Low diversity with the dominance of a particular clone: CC6-MRSA-[IV+fus] (PVL+)•Frequent fusidic acid resistance associated with high prevalence of fusCgene•Recommendation to stop the topical use of fusidic acid

Published
2022
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30. Epidemiology of leprosy in New-Caledonia from 1983 to 2017

Author

Baron, Violaine, Forfait-Dubuc, Carole, Colot, Julien, Cazorla, Cécile, Descloux, Élodie, Cauchoix, Bertrand, Cambau, Emmanuelle, Gaumery, Jean-Baptiste, Grangeon, Jean-Paul, Klement, Élise, Martel, Anne-Sophie, Direction des Affaires sanitaires et sociales de la Nouvelle-Calédonie [Nouméa] (DASS [Nouméa]), Centre hospitalier territorial Gaston-Bourret [Dumbea] (CHT), Centre hospitalier territorial Gaston-Bourret [Nouméa], Fondation Raoul Follereau [Paris], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord

Subjects
Épidémiologie, [SDV] Life Sciences [q-bio], Asia Pacific Region, Epidemiology, [SDV]Life Sciences [q-bio], Lèpre, Nouvelle-Calédonie, New-Caledonia, Mycobacterium, Région Asie-Pacifique Leprosy
Abstract

New-Caledonia (NC) is a French community of the Asia-Pacific region where leprosy is still present. The epidemiological study of reported cases from 1983 to 2017 accounts for 342 cases. Since 1988 the overall annual prevalence is less than 1/10,000 inhabitants, the endemicity threshold set by the World Health Organization. Nevertheless, the study reveals an area of overendemia on the island of Bélep (location of the first leprosarium) where the 2007-2017 annual mean detection rate is 126.5/100,000 inhabitants. Over the last 10 years the predomi nance of multibacillary forms and the discovery of new cases of pediatrics leprosy show the persistence of a transmission in NC. Following this study, public health measures and in-depth studies were implemented., La Nouvelle-Calédonie (NC) est une collectivité française de la région Asie-Pacifique où la lèpre est toujours présente. La surveillance épidémiologique des cas notifiés de 1983 à 2017 comptabilise 342 cas. Depuis 1988, la prévalence globale annuelle est inférieure à 1/10 000 habitants, seuil d'endémicité fixé par l'Organisation mondiale de la Santé. Néanmoins, l'étude révèle une zone de surendémie sur l'île de Bélep (lieu d'implantation de la première léproserie) où le taux de détection moyen annuel 2007-2017 est de 126,5/100 000 habitants. Sur les 10 dernières années, la prédominance de formes multibacillaires et la découverte de nouveaux cas de lèpre pédiatriques démontrent la persistance d'une transmission en NC. Suite à cette étude, des mesures de santé publique et des études approfondies ont été mises en place.

Published
2019

31. Épidémiologie de la lèpre en Nouvelle-Calédonie de 1983 à 2017

Author

Baron, Violaine, Forfait-Dubuc, Carole, Colot, Julien, Cazorla, Cécile, Descloux, Élodie, Cauchoix, Bertrand, Cambau, Emmanuelle, Gaumery, Jean-Baptiste, Grangeon, Jean-Paul, Klement, Élise, Direction des Affaires sanitaires et sociales de la Nouvelle-Calédonie [Nouméa] (DASS [Nouméa]), Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), Centre hospitalier territorial Gaston-Bourret [Dumbea] (CHT), Centre hospitalier territorial Gaston-Bourret [Nouméa], Fondation Raoul Follereau [Paris], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord

Subjects
Épidémiologie, Asia Pacific Region, Epidemiology, [SDV]Life Sciences [q-bio], Lèpre, Nouvelle-Calédonie, New-Caledonia, Mycobacterium, Région Asie-Pacifique Leprosy
Abstract

International audience; New-Caledonia (NC) is a French community of the Asia-Pacific region where leprosy is still present. The epidemiological study of reported cases from 1983 to 2017 accounts for 342 cases. Since 1988 the overall annual prevalence is less than 1/10,000 inhabitants, the endemicity threshold set by the World Health Organization. Nevertheless, the study reveals an area of overendemia on the island of Bélep (location of the first leprosarium) where the 2007-2017 annual mean detection rate is 126.5/100,000 inhabitants. Over the last 10 years the predomi nance of multibacillary forms and the discovery of new cases of pediatrics leprosy show the persistence of a transmission in NC. Following this study, public health measures and in-depth studies were implemented.; La Nouvelle-Calédonie (NC) est une collectivité française de la région Asie-Pacifique où la lèpre est toujours présente. La surveillance épidémiologique des cas notifiés de 1983 à 2017 comptabilise 342 cas. Depuis 1988, la prévalence globale annuelle est inférieure à 1/10 000 habitants, seuil d'endémicité fixé par l'Organisation mondiale de la Santé. Néanmoins, l'étude révèle une zone de surendémie sur l'île de Bélep (lieu d'implantation de la première léproserie) où le taux de détection moyen annuel 2007-2017 est de 126,5/100 000 habitants. Sur les 10 dernières années, la prédominance de formes multibacillaires et la découverte de nouveaux cas de lèpre pédiatriques démontrent la persistance d'une transmission en NC. Suite à cette étude, des mesures de santé publique et des études approfondies ont été mises en place.

Published
2019

32. Host genetic variants near the PAX5 gene locus associate with susceptibility to invasive group A streptococcal disease

Author

Parks, Tom, primary, Auckland, Kathryn, additional, Lamagni, Theresa L., additional, Mentzer, Alexander, additional, Elliott, Katherine, additional, Guy, Rebecca, additional, Cartledge, Doreen, additional, Strakova, Lenka, additional, O’Connor, Daniel, additional, Pollard, Andrew J, additional, Chapman, Stephen J., additional, Thomas, Matthew, additional, Brodlie, Malcolm, additional, Colot, Julien, additional, D’Ortenzio, Eric, additional, Baroux, Noémie, additional, Mirabel, Mariana, additional, Gilchrist, James J., additional, Scott, J. Anthony G., additional, Williams, Thomas N., additional, Knight, Julian, additional, Steer, Andrew C., additional, Hill, Adrian V. S., additional, and Sriskandan, Shiranee, additional

Published
2019
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34. Common genetic variants in the immunoglobulin heavy chain locus and their differential impact on group A streptococcal disease susceptibility: a comparative meta-analysis of genetic susceptibility studies

Author

Parks, Tom, primary, Auckland, Kathryn, additional, Rautanen, Anna, additional, Watson, Corey, additional, Mirabel, Mariana M, additional, Kado, Joseph, additional, Kauwe, John K, additional, Lamagni, Theresa L, additional, Mentzer, Alexander J, additional, Sriskandan, Shiranee, additional, Thomas, Matthew, additional, Chapman, Stephen, additional, Brodlie, Malcolm, additional, Pollard, Andrew J, additional, Colot, Julien, additional, Scott, J Anthony G, additional, Williams, Thomas N, additional, Steer, Andrew C, additional, and Hill, Adrian V S, additional

Published
2017
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37. Prevention and control of highly antibiotic-resistant bacteria in a Pacific territory: feedback from New Caledonia between 2004 and 2020

Author

Colot, Julien, Fouquet, Claire, Ducrocq, Frédérique, Chevalier, Sylvie, Provost, Christine Le, Cazorla, Cécile, Cheval, Camille, Fijalkowski, Caroline, Gourinat, Ann-Claire, Biron, Antoine, Goarant, Cyrille, Bourles, Alexandre, Marot, Benoît, and Saliou, Philippe

Abstract

Objective: Carbapenemase-producing Enterobacteriaceae (CRE) and Enterococcus faeciumresistant to vancomycin (VRE) constitute major threats to public health worldwide. The Pacific area is concerned and has implemented strategies to control antimicrobial resistance (AMR). However, accurate epidemiological data are rarely reported. Our study aimed to present the strategies applied to prevent and control the spread of highly resistant bacteria in the Pacific territory of New Caledonia.

Published
2021
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38. Large-scale HEV genotype 3 outbreak on New Caledonia Island.

Author

Abravanel F, Vignon C, Mercier A, Gaumery JB, Biron A, Filisetti C, Goujart MA, Colot J, Chamillard X, Demortier J, Raz M, Boutet C, Dupont L, Duval S, Castric C, Desoutter D, Desoutter A, Verge M, De Smet C, Demmou S, Lhomme S, Gourinat AC, Nicot F, and Izopet J

Abstract

Background and Aims: Several symptomatic cases of HEV infections were reported to the New Caledonia Island Public Health Service between August and December 2023. This prompted epidemiological and virological investigations to identify the source of infection., Approach and Results: HEV RNA was assessed in symptomatic patients, various food items, and pig farms on the Island. HEV strains were characterized by sequencing. A seroprevalence study was also conducted on asymptomatic blood donors before and after the outbreak. One hundred twenty-seven symptomatic cases were reported. Hospitalization was required for 29/127 patients (22.8%). Hospitalized patients presented more frequently with comorbidities, including liver and cardiovascular diseases (80.7% vs. 27%, p < 0.01), and 3 persons died (2.3%). Among the 100 HEV RNA-positive samples received at the French National Reference Centre for HEV, viral sequencing was possible for 76 samples. All strains were identified as HEV genotype 3, and 74/76 strains were grouped together (nucleotide identity: 98%-100%). Full-length sequencing indicated a new HEV-3 subtype within HEV-3 subclade abk. Only genotype 3f strains were detected on the Island's pig farms. No food items tested positive for HEV RNA. The seroprevalence of HEV IgG and IgM in blood donors was 9.2% (9/98) and 0%, respectively, in 2020, rising to 17.3% (17/98) and 2% (2/98) in 2024., Conclusions: Although all previous large-scale epidemics in Asia and Africa were associated with HEV-1 or 2, the New Caledonia outbreak was linked to HEV-3. A high number of symptomatic cases were admitted to the hospital, with a case-fatality rate of 2.3%., (Copyright © 2024 American Association for the Study of Liver Diseases.)

Published
2024
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39. Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.

Author

Tessier E, Hennart M, Badell E, Passet V, Toubiana J, Biron A, Gourinat AC, Merlet A, Colot J, and Brisse S

Subjects
Female, Humans, Multilocus Sequence Typing, New Caledonia epidemiology, Retrospective Studies, Corynebacterium genetics, Genomics, Anti-Bacterial Agents pharmacology, Tetracycline, Protein Synthesis Inhibitors, Corynebacterium diphtheriae genetics, Diphtheria epidemiology, Diphtheria microbiology
Abstract

An increasing number of isolations of Corynebacterium diphtheriae has been observed in recent years in the archipelago of New Caledonia. We aimed to analyze the clinical and microbiological features of samples with C. diphtheriae. All C. diphtheriae isolates identified in New Caledonia from May 2015 to May 2019 were included. For each case, a retrospective consultation of the patient files was conducted. Antimicrobial susceptibility phenotypes, tox gene and diphtheria toxin expression, biovar, and the genomic sequence were determined. Core genome multilocus sequence typing (cgMLST), 7-gene MLST, and search of genes of interest were performed from genomic assemblies. Fifty-eight isolates were included, with a median age of patients of 28 years (range: 9 days to 78 years). Cutaneous origin accounted for 51 of 58 (87.9%) isolates, and C. diphtheriae was associated with Staphylococcus aureus and/or Streptococcus pyogenes in three-quarters of cases. Half of cases came either from the main city Noumea (24%, 14/58) or from the sparsely populated island of Lifou (26%, 15/58). Six tox -positive isolates were identified, associated with recent travel to Vanuatu; 5 of these cases were linked and cgMLST confirmed recent transmission. Two cases of endocarditis in young female patients with a history of rheumatic fever involved tox -negative isolates. The 58 isolates were mostly susceptible to commonly used antibiotics. In particular, no isolate was resistant to the first-line molecules amoxicillin or erythromycin. Resistance to tetracycline was found in a genomic cluster of 17 (29%) isolates, 16 of which carried the tetO gene. There were 13 cgMLST sublineages, most of which were also observed in the neighboring country Australia. Cutaneous infections may harbor nontoxigenic C. diphtheriae isolates, which circulate largely silently in nonspecific wounds. The possible introduction of tox -positive strains from a neighboring island illustrates that diphtheria surveillance should be maintained in New Caledonia, and that immunization in neighboring islands must be improved. Genomic sequencing uncovers how genotypes circulate locally and across neighboring countries. IMPORTANCE The analysis of C. diphtheriae from the tropical archipelago of New Caledonia revealed a high genetic diversity with sublineages that may be linked to Polynesia, Australia, or metropolitan France. Genomic typing allowed confirming or excluding suspected transmission events among cases and contacts. A highly prevalent tetracycline-resistant sublineage harboring the tetO gene was uncovered. Toxigenic isolates were observed from patients returning from Vanuatu, showing the importance of improving vaccination coverage in settings where it is insufficient. This study also illustrates the importance for diphtheria surveillance of the inclusion of isolates from cutaneous sources in addition to respiratory cases, in order to provide a more complete epidemiological picture of the diversity and transmission of C. diphtheriae., Competing Interests: The authors declare no conflict of interest.

Published
2023
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40. Flying Fox Hemolytic Fever, Description of a New Zoonosis Caused by Candidatus Mycoplasma haemohominis.

Author

Descloux E, Mediannikov O, Gourinat AC, Colot J, Chauvet M, Mermoud I, Desoutter D, Cazorla C, Klement-Frutos E, Antonini L, Levasseur A, Bossi V, Davoust B, Merlet A, Goujart MA, Oedin M, Brescia F, Laumond S, Fournier PE, and Raoult D

Subjects
Animals, Humans, Phylogeny, Retrospective Studies, Chiroptera, Mycoplasma genetics, Mycoplasma Infections diagnosis, Mycoplasma Infections veterinary
Abstract

Background: Hemotropic mycoplasmas, previously classified in the genus Eperythrozoon, have been reported as causing human infections in Brazil, China, Japan, and Spain., Methods: In 2017, we detected DNA from Candidatus Mycoplasma haemohominis in the blood of a Melanesian patient from New Caledonia presenting with febrile splenomegaly, weight loss, life-threatening autoimmune hemolytic anemia, and hemophagocytosis. The full genome of the bacterium was sequenced from a blood isolate. Subsequently, we retrospectively (2011-2017) and prospectively (2018-2019) tested patients who had been hospitalized with a similar clinico-biological picture. In addition, as these patients had been in contact with frugivorous bats (authorized under conditions for hunting and eating in New Caledonia), we investigated the role of these animals and their biting flies by testing them for hemotropic mycoplasmas., Results: There were 15 patients found to be infected by this hemotropic mycoplasma. Among them, 4 (27%) died following splenectomy performed either for spontaneous spleen rupture or to cure refractory autoimmune hemolytic anemia. The bacterium was cultivated from the patient's blood. The full genome of the Neocaledonian Candidatus M. haemohominis strain differed from that of a recently identified Japanese strain. Of 40 tested Pteropus bats, 40% were positive; 100% of collected bat flies Cyclopodia horsfieldi (Nycteribiidae, Diptera) were positive. Human, bat, and dipteran strains were highly similar., Conclusions: The bacterium being widely distributed in bats, Candidatus M. haemohominis, should be regarded as a potential cause of severe infections in humans., (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Published
2021
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