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2. Impact of trametinib on the neuropsychological profile of NF1 patients

Author

Lalancette, Eve, Cantin, Édith, Routhier, Marie-Ève, Mailloux, Chantal, Bertrand, Marie-Claude, Kiaei, Dorsa Sadat, Larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, McKeown, Tara, Ospina, Luis H., Vairy, Stéphanie, Ramaswamy, Vijay, Coltin, Hallie, Sultan, Serge, Legault, Geneviève, Bouffet, Éric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Caru, Maxime, Dehaes, Mathieu, Jabado, Nada, Perreault, Sébastien, and Lippé, Sarah

Published
2024
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4. Long-Term Sequelae

Author

Perreault, Sebastien, Desjardins, Leandra, Coltin, Hallie, Scheinemann, Katrin, Scheinemann, Katrin, editor, and Bouffet, Eric, editor

Published
2024
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5. Subgroup and subtype-specific outcomes in adult medulloblastoma.

Author

Coltin, Hallie, Sundaresan, Lakshmikirupa, Smith, Kyle, Skowron, Patryk, Massimi, Luca, Eberhart, Charles, Schreck, Karisa, Gupta, Nalin, Weiss, William, Tirapelli, Daniela, Carlotti, Carlos, Li, Kay, Ryzhova, Marina, Golanov, Andrey, Zheludkova, Olga, Absalyamova, Oksana, Okonechnikov, Konstantin, Stichel, Damian, von Deimling, Andreas, Giannini, Caterina, Raskin, Scott, Van Meir, Erwin, Chan, Jennifer, Fults, Daniel, Chambless, Lola, Kim, Seung-Ki, Vasiljevic, Alexandre, Faure-Conter, Cecile, Vibhakar, Rajeev, Jung, Shin, Leary, Sarah, Mora, Jaume, McLendon, Roger, Pollack, Ian, Hauser, Peter, Grajkowska, Wieslawa, Rubin, Joshua, van Veelen, Marie-Lise, French, Pim, Kros, Johan, Liau, Linda, Pfister, Stefan, Kool, Marcel, Kijima, Noriyuki, Taylor, Michael, Packer, Roger, Northcott, Paul, Korshunov, Andrey, and Ramaswamy, Vijay

Subjects
Adult, DNA methylation profiling, Medulloblastoma, Molecular groups, Risk stratification, Adolescent, Adult, Biomarkers, Tumor, Cerebellar Neoplasms, Cohort Studies, Female, Humans, Male, Medulloblastoma, Progression-Free Survival, Risk Factors, Young Adult
Abstract

Medulloblastoma, a common pediatric malignant central nervous system tumour, represent a small proportion of brain tumours in adults. Previously it has been shown that in adults, Sonic Hedgehog (SHH)-activated tumours predominate, with Wingless-type (WNT) and Group 4 being less common, but molecular risk stratification remains a challenge. We performed an integrated analysis consisting of genome-wide methylation profiling, copy number profiling, somatic nucleotide variants and correlation of clinical variables across a cohort of 191 adult medulloblastoma cases identified through the Medulloblastoma Advanced Genomics International Consortium. We identified 30 WNT, 112 SHH, 6 Group 3, and 41 Group 4 tumours. Patients with SHH tumours were significantly older at diagnosis compared to other subgroups (p

Published
2021

7. Full and Partial Facial Affect Recognition in Pediatric Brain Tumour Survivors and Typically Developing Children Following COVID-19 Pandemic.

Author

Buron, Laurianne, Perreault, Sébastien, Sultan, Serge, Bonanno, Marco, Coltin, Hallie, Laverdière, Caroline, Rondeau, Émélie, and Desjardins, Leandra

Subjects
RECOGNITION (Psychology), SOCIAL adjustment, FACIAL expression, SOCIAL skills, BRAIN tumors
Abstract

Affect recognition has emerged as a potential mechanism underlying the social competence challenges experienced by pediatric brain tumour survivors (PBTSs). However, many social interactions were altered during the pandemic, with the widespread use of masking potentially impacting affect recognition abilities. Here, we examine affect recognition in PBTSs and typically developing youth (TD) after the onset of the global pandemic. Twenty-three PBTSs and 24 TD between 8 and 16 years old were recruited and completed two performance-based affect recognition tasks (full and partial facial features) and a self-reported questionnaire on mask exposure in their social interactions. Their parents completed parent proxy questionnaires on their child's social adjustment and sociodemographics. The scores between the PBTSs and TD did not differ significantly in full (t(45) = 1.33, p = 0.19, d = 0.39, 95% CI [−0.69, 3.40]) or partial (t(37.36) = 1.56, p = 0.13, d = 0.46, 95% CI [−0.47, 3.60]) affect recognition, suggesting similar affect recognition between the two groups. These skills were also not significantly correlated with social adjustment or mask exposure (p > 0.05). However, the combined sample had significantly better scores in affect recognition when exposed to partial facial cues versus full. Additionally, participants obtained lower scores on a measure of full facial affect recognition and higher scores on a measure of partial affect recognition compared to pre-pandemic data. The pandemic may have influenced affect recognition across youth, underscoring the importance of further research into its lasting impact on the social competence of youth. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Canadian Consensus for Treatment of BRAF V600E Mutated Pediatric and AYA Gliomas.

Author

Erker, Craig, Vanan, Magimairajan Issai, Larouche, Valérie, Nobre, Liana, Cacciotti, Chantel, Vairy, Stéphanie, Zelcer, Shayna, Fleming, Adam, Bouffet, Eric, Jabado, Nada, Legault, Geneviève, Renzi, Samuele, McKeown, Tara, Crooks, Bruce, Thacker, Nirav, Ramaswamy, Vijay, Coltin, Hallie, Lafay-Cousin, Lucie, Cheng, Sylvia, and Hukin, Juliette

Subjects
BRAF genes, GLIOMAS, TERMINATION of treatment, YOUNG adults, TREATMENT duration
Abstract

Background: The treatment of BRAF V600E gliomas with BRAF inhibitors (BRAFis) and MEK inhibitors (MEKis) has been increasingly integrated into clinical practice for pediatric low-grade gliomas (PLGGs) and pediatric high-grade gliomas (HGGs). However, some questions remain unanswered, such as the best time to start targeted therapy, duration of treatment, and discontinuation of therapy. Given that no clinical trial has been able to address these critical questions, we developed a Canadian Consensus statement for the treatment of BRAF V600E mutated pediatric as well as adolescent and young adult (AYA) gliomas. Methods: Canadian neuro-oncologists were invited to participate in the development of this consensus. The consensus was discussed during monthly web-based national meetings, and the algorithms were revised until a consensus was achieved. Results: A total of 26 participants were involved in the development of the algorithms. Two treatment algorithms are proposed, one for the initiation of treatment and one for the discontinuation of treatment. We suggest that most patients with BRAF V600E gliomas should be treated with BRAFis ± MEKis upfront. Discontinuation of treatment can be considered in certain circumstances, and we suggest a slow wean. Conclusions: Based on expert consensus in Canada, we developed algorithms for treatment initiation of children and AYA with BRAF V600E gliomas as well as a discontinuation algorithm. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature

Author

Michaiel, George, Strother, Douglas, Gottardo, Nicholas, Bartels, Ute, Coltin, Hallie, Hukin, Juliette, Wilson, Beverly, Zelcer, Shayna, Hansford, Jordan R., Hassall, Timothy, AbdelBaki, Mohamed S., Cole, Kristina A., Hoffman, Lindsey, Smiley, Natasha P., Smith, Amy, Vinitsky, Anna, Vitanza, Nicholas A., Wright, Avery, Yeo, Kee K., Chow, Lionel M. L., Vanan, Magimairajan I., Dhall, Girish, Bouffet, Eric, and Lafay-Cousin, Lucie

Published
2020
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10. Performance of the eHealth decision support tool, MIPOGG, for recognising children with Li-Fraumeni, DICER1, Constitutional mismatch repair deficiency and Gorlin syndromes.

Author

Hebert, Robyn, Cullinan, Noelle, Armstrong, Linlea, Blood, Katherine A., Brossard, Josee, Brunga, Ledia, Cacciotti, Chantel, Caswell, Kimberly, Cellot, Sonia, Coltin, Hallie, Deyell, Rebecca J., Felton, Kathleen, Fernandez, Conrad V., Fleming, Adam J., Gibson, Paul, Hammad, Rawan, Jabado, Nada, Johnston, Donna L., Lafay-Cousin, Lucie, and Larouche, Valérie

Abstract

Background Cancer predisposition syndromes (CPSs) are responsible for at least 10% of cancer diagnoses in children and adolescents, most of which are not clinically recognised prior to cancer diagnosis. A variety of clinical screening guidelines are used in healthcare settings to help clinicians detect patients who have a higher likelihood of having a CPS. The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) is an electronic health decision support tool that uses algorithms to help clinicians determine if a child/adolescent diagnosed with cancer should be referred to genetics for a CPS evaluation. Methods This study assessed MIPOGG’s performance in identifying Li-Fraumeni, DICER1, Constitutional mismatch repair deficiency and Gorlin (nevoid basal cell carcinoma) syndromes in a retrospective series of 84 children diagnosed with cancer and one of these four CPSs in Canadian hospitals over an 18-year period. Results MIPOGG detected 82 of 83 (98.8%) evaluable patients with any one of these four genetic conditions and demonstrated an appropriate rationale for suggesting CPS evaluation. When compared with syndrome-specific clinical screening criteria, MIPOGG’s ability to correctly identify children with any of the four CPSs was equivalent to, or outperformed, existing clinical criteria respective to each CPS. Conclusion This study adds evidence that MIPOGG is an appropriate tool for CPS screening in clinical practice. MIPOGG’s strength is that it starts with a specific cancer diagnosis and incorporates criteria relevant for associated CPSs, making MIPOGG a more universally accessible diagnostic adjunct that does not require in-depth knowledge of each CPS. [ABSTRACT FROM AUTHOR]

Published
2023
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11. A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma

Author

Ng, Chia Huan, primary, Obrecht, Denise, additional, Wells, Olivia, additional, Zapotocky, Michal, additional, Sumerauer, David, additional, Coltin, Hallie, additional, Khuong-Quang, Dong-Anh, additional, Eisenstat, David D, additional, Kinross, Kathryn M, additional, White, Christine L, additional, Algar, Elizabeth M, additional, Luck, Amanda, additional, Witt, Hendrik, additional, Schüller, Ulrich, additional, Mynarek, Martin, additional, Pietsch, Torsten, additional, Gerber, Nicolas U, additional, Benesch, Martin, additional, Warmuth-Metz, Monika, additional, Kortmann, Rolf, additional, Bison, Brigitte, additional, Taylor, Michael D, additional, Rutkowski, Stefan, additional, Pfister, Stefan M, additional, Jones, David T W, additional, Gottardo, Nicholas G, additional, von Hoff, Katja, additional, Pajtler, Kristian W, additional, Ramaswamy, Vijay, additional, and Hansford, Jordan R, additional

Published
2023
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12. A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma

Author

Ng, Chia Huan, Obrecht, Denise, Wells, Olivia, Zapotocky, Michal, Sumerauer, David, Coltin, Hallie, Khuong-Quang, Dong-Anh, Eisenstat, David D; https://orcid.org/0000-0002-5976-0798, Kinross, Kathryn M, White, Christine L, Algar, Elizabeth M, Luck, Amanda, Witt, Hendrik, Schüller, Ulrich; https://orcid.org/0000-0002-8731-1121, Mynarek, Martin; https://orcid.org/0000-0003-3302-2719, Pietsch, Torsten, Gerber, Nicolas U, Benesch, Martin, Warmuth-Metz, Monika; https://orcid.org/0000-0002-3544-319X, Kortmann, Rolf, Bison, Brigitte, Taylor, Michael D, Rutkowski, Stefan, Pfister, Stefan M, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Gottardo, Nicholas G; https://orcid.org/0000-0002-1082-6776, von Hoff, Katja; https://orcid.org/0000-0002-5669-8546, Pajtler, Kristian W; https://orcid.org/0000-0002-3562-6121, Ramaswamy, Vijay; https://orcid.org/0000-0002-6557-895X, Hansford, Jordan R; https://orcid.org/0000-0001-7733-383X, Ng, Chia Huan, Obrecht, Denise, Wells, Olivia, Zapotocky, Michal, Sumerauer, David, Coltin, Hallie, Khuong-Quang, Dong-Anh, Eisenstat, David D; https://orcid.org/0000-0002-5976-0798, Kinross, Kathryn M, White, Christine L, Algar, Elizabeth M, Luck, Amanda, Witt, Hendrik, Schüller, Ulrich; https://orcid.org/0000-0002-8731-1121, Mynarek, Martin; https://orcid.org/0000-0003-3302-2719, Pietsch, Torsten, Gerber, Nicolas U, Benesch, Martin, Warmuth-Metz, Monika; https://orcid.org/0000-0002-3544-319X, Kortmann, Rolf, Bison, Brigitte, Taylor, Michael D, Rutkowski, Stefan, Pfister, Stefan M, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Gottardo, Nicholas G; https://orcid.org/0000-0002-1082-6776, von Hoff, Katja; https://orcid.org/0000-0002-5669-8546, Pajtler, Kristian W; https://orcid.org/0000-0002-3562-6121, Ramaswamy, Vijay; https://orcid.org/0000-0002-6557-895X, and Hansford, Jordan R; https://orcid.org/0000-0001-7733-383X

Abstract

BACKGROUND ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma (ZFTAfus ST-EPN) has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ZFTAfus ST-EPN was reported to portend poorer prognosis when compared to its counterpart, YAP1 ST-EPN in some previously published series. The aim of this study was to determine the treatment outcome of molecularly confirmed and conventionally treated ZFTAfus ST-EPN patients treated in multiple institutions. METHODS We conducted a retrospective analysis of all pediatric patients with molecularly confirmed ZFTAfus ST-EPN patients treated in multiple institutions in 5 different countries (Australia, Canada, Germany, Switzerland, and Czechia). Survival outcomes were analyzed and correlated with clinical characteristics and treatment approaches. RESULTS A total of 108 patients were collated from multiple institutions in 5 different countries across three continents. We found across the entire cohort that the 5- and 10-year PFS were 65% and 63%, respectively. The 5- and 10-year OS of this cohort of patients were 87% and 73%. The rates of gross total resection (GTR) were high with 84 out of 108 (77.8%) patients achieving GTR. The vast majority of patients also received post-operative radiotherapy, 98 out of 108 (90.7%). Chemotherapy did not appear to provide any survival benefit in our patient cohort. CONCLUSION This is the largest study to date of contemporaneously treated molecularly confirmed ZFTAfus ST-EPN patients which identified markedly improved survival outcomes compared to previously published series. This study also re-emphasizes the importance of maximal surgical resection in achieving optimal outcomes in pediatric patients with supratentorial ependymoma.

Published
2023

14. CTNI-04. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PEDIATRIC PATIENTS WITH NEUROFIBROMATOSIS TYPE 1 AND PLEXIFORM NEUROFIBROMAS

Author

Kiaei, Dorsa Sadat, primary, Larouche, Valerie, additional, Décarie, Jean-Claude, additional, Tabori, Uri, additional, Hawkins, Cynthia, additional, Lippe, Sarah, additional, Ellezam, Benjamin, additional, Ospina, Luis H, additional, Theoret, Yves, additional, Desjardins, Leandra, additional, Metras, Marie-Elaine, additional, Sultan, Serge, additional, Cantin, Edith, additional, Routhier, Marie-Eve, additional, Mailloux, Chantal, additional, Bertrand, Marie-claude, additional, Caru, Maxime, additional, McKeown, Tara, additional, Vairy, Stephanie, additional, Legault, Geneviève, additional, Bouffet, Eric, additional, Ramaswamy, Vijay, additional, Coltin, Hallie, additional, Lafay-Cousin, Lucie, additional, Hukin, Juliette, additional, Erker, Craig, additional, Jabado, Nada, additional, Dehaes, Mathieu, additional, and Perreault, Sébastien, additional

Published
2022
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16. NFB-08. TRAM-01: A Phase 2 study of trametinib for pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas

Author

Kiaei, Dorsa Sadat, primary, Larouche, Valérie, additional, Décarie, Jean-Claude, additional, Tabori, Uri, additional, Hawkin, Cynthia, additional, Lippé, Sarah, additional, Ellezam, Benjamin, additional, Ospina, Luis H, additional, Théoret, Yves, additional, Desjardins, Léandra, additional, Métras, Marie-Élaine, additional, Sultan, Serge, additional, Cantin, Édith, additional, Routhier, Marie-Ève, additional, Mailloux, Chantal, additional, Bertrand, Marie-Claude, additional, Caru, Maxime, additional, Vairy, Stéphanie, additional, Legault, Geneviève, additional, Bouffet, Éric, additional, Ramaswamy, Vijay, additional, Coltin, Hallie, additional, Lafay-Cousin, Lucie, additional, Hukin, Juliette, additional, Erker, Craig, additional, Jabado, Nada, additional, Dehaes, Mathieu, additional, and Perreault, Sébastien, additional

Published
2022
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18. HGG-11. Clinical characteristics and clinical evolution of a large cohort of pediatric patients with primary central nervous system (CNS) tumors and tropomyosin receptor kinase (TRK) fusion.

Author

Lamoureux, Audrey-Anne, primary, Fisher, Michael, additional, Lemelle, Lauriane, additional, Pfaff, Elke, additional, Kramm, Christof, additional, De Wilde, Bram, additional, Kazanowska, Bernarda, additional, Hutter, Caroline, additional, Pfister, Stefan M, additional, Sturm, Dominik, additional, Jones, David, additional, Orbach, Daniel, additional, Pierron, Gaëlle, additional, Raskin, Scott, additional, Drilon, Alexander, additional, Diamond, Eli, additional, Harada, Guilherme, additional, Zapotocky, Michal, additional, Ellezam, Benjamin, additional, Weil, Alexander G, additional, Venne, Dominic, additional, Barritault, Marc, additional, Leblond, Pierre, additional, Coltin, Hallie, additional, Hammad, Rawan, additional, Tabori, Uri, additional, Hawkins, Cynthia, additional, Hansford, Jordan R, additional, Meyran, Deborah, additional, Erker, Craig, additional, McFadden, Kathryn, additional, Sato, Mariko, additional, Gottardo, Nicholas G, additional, Dholaria, Hetal, additional, Nørøxe, Dorte Schou, additional, Goto, Hiroaki, additional, Ziegler, David S, additional, Lin, Frank Y, additional, Parsons, Donald Williams, additional, Lindsay, Holly, additional, Wong, Tai-Tong, additional, Liu, Yen-Lin, additional, Wu, Kuo-Sheng, additional, Franson, Andrea Flynn, additional, Hwang, Eugene, additional, Aguilar-Bonilla, Ana, additional, Cheng, Sylvia, additional, Cacciotti, Chantel, additional, Massimino, Maura, additional, Schiavello, Elisabetta, additional, Wood, Paul, additional, Hoffman, Lindsey M, additional, Cappellano, Andréa, additional, Lassaletta, Alvaro, additional, Van Damme, An, additional, Llort, Anna, additional, Gerber, Nicolas U, additional, Ceruso, Mariella Spalato, additional, Bendel, Anne E, additional, Skrypek, Maggie, additional, Hamideh, Dima, additional, Mushtaq, Naureen, additional, Walter, Andrew, additional, Jabado, Nada, additional, Alsahlawi, Aysha, additional, Farmer, Jean-Pierre, additional, Abadi, Christina Coleman, additional, Mueller, Sabine, additional, Mazewski, Claire, additional, Aguilera, Dolly, additional, Robison, Nathan, additional, O’Halloran, Katrina, additional, Abbou, Samuel, additional, Berlanga, Pablo, additional, Geoerger, Birgit, additional, Øra, Ingrid, additional, Moertel, Christopher L, additional, Razis, Evangelia D, additional, Vernadou, Anastasia, additional, Doz, François, additional, Laetsch, Theodore W, additional, and Perreault, Sébastien, additional

Published
2022
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20. Selumetinib for symptomatic, inoperable plexiform neurofibromas in children with neurofibromatosis type 1: A national real‐world case series

Author

Coltin, Hallie, primary, Perreault, Sébastien, additional, Larouche, Valérie, additional, Black, Karina, additional, Wilson, Bev, additional, Vanan, Magimairajan Issai, additional, Gupta, Abha A., additional, Morgenstern, Daniel A., additional, Parkin, Patricia C., additional, Bouffet, Eric, additional, and Ramaswamy, Vijay, additional

Published
2022
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22. Performance of the McGill Interactive Pediatric OncoGenetic Guidelines for Identifying Cancer Predisposition Syndromes

Author

Goudie, Catherine, primary, Witkowski, Leora, additional, Cullinan, Noelle, additional, Reichman, Lara, additional, Schiller, Ian, additional, Tachdjian, Melissa, additional, Armstrong, Linlea, additional, Blood, Katherine A., additional, Brossard, Josée, additional, Brunga, Ledia, additional, Cacciotti, Chantel, additional, Caswell, Kimberly, additional, Cellot, Sonia, additional, Clark, Mary Egan, additional, Clinton, Catherine, additional, Coltin, Hallie, additional, Felton, Kathleen, additional, Fernandez, Conrad V., additional, Fleming, Adam J., additional, Fuentes-Bolanos, Noemi, additional, Gibson, Paul, additional, Grant, Ronald, additional, Hammad, Rawan, additional, Harrison, Lynn W., additional, Irwin, Meredith S., additional, Johnston, Donna L., additional, Kane, Sarah, additional, Lafay-Cousin, Lucie, additional, Lara-Corrales, Irene, additional, Larouche, Valerie, additional, Mathews, Natalie, additional, Meyn, M. Stephen, additional, Michaeli, Orli, additional, Perrier, Renée, additional, Pike, Meghan, additional, Punnett, Angela, additional, Ramaswamy, Vijay, additional, Say, Jemma, additional, Somers, Gino, additional, Tabori, Uri, additional, Thibodeau, My Linh, additional, Toupin, Annie-Kim, additional, Tucker, Katherine M., additional, van Engelen, Kalene, additional, Vairy, Stephanie, additional, Waespe, Nicolas, additional, Warby, Meera, additional, Wasserman, Jonathan D., additional, Whitlock, James A., additional, Sinnett, Daniel, additional, Jabado, Nada, additional, Nathan, Paul C., additional, Shlien, Adam, additional, Kamihara, Junne, additional, Deyell, Rebecca J., additional, Ziegler, David S., additional, Nichols, Kim E., additional, Dendukuri, Nandini, additional, Malkin, David, additional, Villani, Anita, additional, and Foulkes, William D., additional

Published
2021
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25. IMPACT: Prevalence and Predictors of High-Intensity End-of-Life Care Among Adolescents and Young Adults with Cancer in Ontario

Author

Coltin, Hallie

Subjects
Young adult, Adolescent, humanities, Cancer, End-of-life
Abstract

Adolescents and young adults (AYA) with cancer may experience disproportionate rates of high-intensity (HI) end-of-life (EOL) care. We conducted a population-based linkage study examining a decedent cohort of all Ontario AYA aged 15-21 years diagnosed with six primary cancers between 1992-2012. The primary composite outcome (HI-EOL care) included any of: intravenous chemotherapy ≤14 days from death; >1 emergency department visit; >1 hospitalization; or any intensive care unit (ICU) admission ≤30 days from death. Secondary outcomes included hospital deaths and measures of most invasive (MI)-EOL care. The outcome prevalence trends were examined, as were the predictors using regression models. Of 483 patients, 292 (60.5%) experienced HI-EOL care. AYA with hematological malignancies and relapsed disease experienced the highest and lowest odds of all outcomes, respectively. The prevalence of MI-EOL care may be increasing, especially for pediatric patients. This work is the first to identify LOC-based disparities in AYA EOL care.

Published
2021
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26. Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

Author

Baroni, Lorena V, primary, Sundaresan, Lakshmikirupa, additional, Heled, Ayala, additional, Coltin, Hallie, additional, Pajtler, Kristian W, additional, Lin, Tong, additional, Merchant, Thomas E, additional, McLendon, Roger, additional, Faria, Claudia, additional, Buntine, Molly, additional, White, Christine L, additional, Pfister, Stefan M, additional, Gilbert, Mark R, additional, Armstrong, Terri S, additional, Bouffet, Eric, additional, Kumar, Sachin, additional, Taylor, Michael D, additional, Aldape, Kenneth D, additional, Ellison, David W, additional, Gottardo, Nicholas G, additional, Kool, Marcel, additional, Korshunov, Andrey, additional, Hansford, Jordan R, additional, and Ramaswamy, Vijay, additional

Published
2021
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28. Canadian Pediatric Neuro-Oncology Standards of Practice

Author

Bennett, Julie, primary, Erker, Craig, additional, Lafay-Cousin, Lucie, additional, Ramaswamy, Vijay, additional, Hukin, Juliette, additional, Vanan, Magimairajan I., additional, Cheng, Sylvia, additional, Coltin, Hallie, additional, Fonseca, Adriana, additional, Johnston, Donna, additional, Lo, Andrea, additional, Zelcer, Shayna, additional, Alvi, Saima, additional, Bowes, Lynette, additional, Brossard, Josée, additional, Charlebois, Janie, additional, Eisenstat, David, additional, Felton, Kathleen, additional, Fleming, Adam, additional, Jabado, Nada, additional, Larouche, Valérie, additional, Legault, Geneviève, additional, Mpofu, Chris, additional, Perreault, Sébastien, additional, Silva, Mariana, additional, Sinha, Roona, additional, Strother, Doug, additional, Tsang, Derek S., additional, Wilson, Beverly, additional, Crooks, Bruce, additional, and Bartels, Ute, additional

Published
2020
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29. LGG-19. SPINAL LOW-GRADE GLIOMAS IN CANADIAN CHILDREN: A MULTI-CENTRE RETROSPECTIVE REVIEW

Author

Coltin, Hallie, primary, Benipal, Savvy, additional, Rassekh, S Rod, additional, Nobre, Liana Figueiredo, additional, Bennett, Julie, additional, Tabori, Uri, additional, Wilson, Bev, additional, Mehta, Vivek, additional, Beaudoin, Wendy, additional, Zelcer, Shayna, additional, Cheng, Sylvia, additional, Hukin, Juliette, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, and Johnston, Donna, additional

Published
2020
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31. Locus‐of‐care disparities in end‐of‐life care intensity among adolescents and young adults with cancer: A population‐based study using the IMPACT cohort.

Author

Coltin, Hallie, Rapoport, Adam, Baxter, Nancy N., Nagamuthu, Chenthila, Nathan, Paul C., Pole, Jason D., Momoli, Franco, and Gupta, Sumit

Subjects
*YOUNG adults, *CANCER patients, *TERMINAL care, *TEENAGERS, *INTENSIVE care units, *ADOLESCENT gynecology, *PEDIATRIC intensive care
Abstract

Background: Adolescents and young adults (AYAs) with cancer may experience elevated rates of high‐intensity end‐of‐life (HI‐EOL) care. Locus‐of‐care (LOC) disparities (pediatric vs adult) in AYA end‐of‐life (EOL) care are unstudied. Methods: A decedent population‐based cohort of Ontario AYAs diagnosed between 1992 and 2012 at the ages of 15 to 21 years was linked to administrative data. The authors determined the prevalence and associations of a composite outcome of HI‐EOL care that included any of the following: intravenous chemotherapy within 14 days of death, more than 1 emergency department visit, more than 1 hospitalization, or an intensive care unit (ICU) admission within 30 days of death. Secondary outcomes included measures of the most invasive EOL care (ventilation within 14 days of death and ICU death) and in‐hospital death. Results: There were 483 decedents: 60.5% experienced HI‐EOL care, 20.3% were ventilated, and 22.8% died in the ICU. Compared with patients with solid tumors, patients with hematological malignancies had the greatest odds of HI‐EOL care (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.5‐3.4), ventilation (OR, 4.7; 95% CI, 2.7‐8.3), and ICU death (OR, 4.4; 95% CI, 2.6‐4.4). Subjects treated in pediatric centers versus adult centers near death (OR, 2.4; 95% CI, 1.2‐4.8) and those living in rural areas (OR, 2.1; 95% CI, 1.1‐3.9) were more likely to experience ICU death. Conclusions: AYAs with cancer experience high rates of HI‐EOL care, with patients in pediatric centers and those living in rural areas having the highest odds of ICU death. This study is the first to identify LOC‐based disparities in EOL care for AYAs, and it highlights the need to explore the mechanisms underlying these disparities. In this population‐based linkage study of adolescent and young adult cancer decedents, patients treated in pediatric settings near death experience disproportionate rates of intensive end‐of‐life care in comparison with adult settings. Other risk factors are hematological malignancies and rural living. [ABSTRACT FROM AUTHOR]

Published
2022
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33. GERM-23. INTRACRANIAL GROWING TERATOMA SYNDROME (IGTS): AN INTERNATIONAL RETROSPECTIVE STUDY

Author

Michaiel, George, primary, Strother, Douglas, additional, Gottardo, Nicholas, additional, Bartels, Ute, additional, Coltin, Hallie, additional, Eisenstat, David D, additional, Hukin, Juliette, additional, Johnston, Donna L, additional, Wilson, Beverly, additional, Zelcer, Shayna, additional, Hansford, Jordan R, additional, Wells, Olivia, additional, AbdelBaki, Mohamed S, additional, Abu-Arja, Mohammad H, additional, Cole, Kristina A, additional, Dhall, Girish, additional, Fisher, Paul G, additional, Hoffman, Lindsey, additional, Leary, Sarah E S, additional, Pickle, Emily E Owens, additional, Smiley, Natasha P, additional, Smith, Amy, additional, Vinitsky, Anna, additional, Vitanza, Nicholas A, additional, Wright, Avery, additional, Yeo, Kee K, additional, Chow, Lionel M L, additional, Kirby, Maria, additional, Valvi, Santosh, additional, Vanan, Magimairajan I, additional, Wong, Grace, additional, Ziegler, David, additional, Bouffet, Eric, additional, and Lafay-Cousin, Lucie, additional

Published
2018
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35. 31 Intracranial growing teratoma syndrome (IGTS): An international retrospective study

Author

Michaiel, George, primary, Strother, Douglas, additional, Gottardo, Nicholas, additional, Bartels, Ute, additional, Coltin, Hallie, additional, Eisenstat, David D., additional, Hukin, Juliette, additional, Johnston, Donna L., additional, Wilson, Beverly, additional, Zelcer, Shayna, additional, Hansford, Jordan R., additional, Wells, Olivia, additional, AbdelBaki, Mohamed S., additional, Abu-Arja, Mohammad H., additional, Cole, Kristina A., additional, Dhall, Girish, additional, Fisher, Paul G., additional, Hoffman, Lindsey, additional, Leary, Sarah E.S., additional, Owens Pickle, Emily E., additional, Smiley, Natasha P., additional, Smith, Amy, additional, Vinitsky, Anna, additional, Vitanza, Nicholas A., additional, Wright, Avery, additional, Yeo, Kee K., additional, Chow, Lionel M.L., additional, Kirby, Maria, additional, Valvi, Santosh, additional, Vanan, Magimairajan I., additional, Wong, Grace, additional, Ziegler, David, additional, Bouffet, Eric, additional, and Lafay-Cousi, Lucie, additional

Published
2018
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38. CASE 2 DIAGNOSIS: BEHÇET DISEASE.

Author

Coltin, Hallie, Soon, Gordon S., Luca, Nadia, and Tse, Shirley M. L.

Subjects
*ULCER diagnosis, *BEHCET'S disease, *DIAGNOSIS
Abstract

The article presents a case study of a 14-year-old Lebanese girl presented with a one-year history of intermittent and painful vulvar ulcers where physical examination found to have bilateral papillitis and panuveitis on a screening ophthalmological examination. She was diagnosed with Behçet disease, a relapsing inflammatory disorder with multisystem involvement. The author further discusses the clinical features and important differential diagnoses of the disease.

Published
2013

40. Impact of the COVID-19 Pandemic Onset on the Early Careers of Pediatric Oncology Health Professionals and Researchers: A Report From the Children's Oncology Group Young Investigators Committee, Young SIOP Network, and Young SIOPE.

Author

Bryan G, Guolla L, Villanueva GI, Cohen-Gogo S, Casanovas A, Medina R, Revon-Riviere G, Coltin H, Kahalley LS, Withycombe JS, van Ewijk R, Schoot RA, Cash T, Baertschiger RM, McAleer MF, Benedetti DJ, Greengard E, Kitko CL, Green AL, Dhall G, and Esbenshade AJ

Abstract

Introduction: The COVID-19 pandemic onset had a global debilitating impact on individuals and on burgeoning careers. In 2021, the Children's Oncology Group Young Investigators Committee, Young SIOP (International Society of Paediatric Oncology) Network, and Young SIOPE (European Society for Paediatric Oncology) co-sponsored a survey to explore the impacts of the first year of the pandemic on early-career pediatric oncology professionals with respect to working practices, productivity, professional and career development, personal wellbeing, and changing childcare needs., Methods: The survey comprised demographic, multiple-choice, and free-text questions, and was distributed via email and social media with English, French, and Spanish versions available. Descriptive statistics and chi-square tests were used to compare quantitative data by self-designated gender and country of origin. Qualitative data were described using content analysis., Results: Professionals (N = 499, 26.3% male, 77.2% MDs) in 48 countries (77.6% high income) responded in English (79.4%), Spanish (12.4%), and French (8.2%). Respondents had difficulty obtaining and keeping jobs (26.9%), worsened overall academic productivity (50.7%, with higher rates among bench scientists, p < 0.01), and decreased career opportunities (40.9%). Childcare challenges impacted 56.7% of respondents and was felt more negatively among women (p = 0.008) and in high-income settings (p < 0.0001). Qualitative data (n = 300) highlighted these differences were often attributable to diminished professional/personal boundaries and impacted their personal wellbeing., Conclusion: The COVID-19 pandemic significantly impacted early-career academic and clinical professionals working in pediatric oncology, with unique challenges noted among those with childcare responsibilities. Career disruptions that resulted from the pandemic should be considered and mitigated by governing bodies and hiring institutions., (© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.)

Published
2024
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