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4. P544 Ustekinumab safety and effectiveness in ulcerative colitis patients: results from a large real-life study

Author

Mocci, G, primary, Scaldaferri, F, additional, Pugliese, D, additional, Savarino, E, additional, Bodini, G, additional, Cuomo, A, additional, Donnarumma, L, additional, Maconi, G, additional, Cataletti, G, additional, Rodino, S, additional, Sebkova, L, additional, Ferronato, A, additional, Gaiani, F, additional, Marzo, M, additional, Luppino, I, additional, Paese, P, additional, Elisei, W, additional, Monterubbianesi, R, additional, Faggiani, R, additional, Napolitano, D, additional, Grossi, L, additional, Serio, M, additional, Scarcelli, A, additional, Lorenzetti, R, additional, Allegretta, L, additional, Rocco, G, additional, Zampaletta, C, additional, Bolognini, L, additional, Meucci, C, additional, Colucci, R, additional, Tonti, P, additional, Della Valle, N, additional, Piga, R, additional, Forti, G, additional, Onidi, F M, additional, Usai Satta, P, additional, Picchio, M, additional, Papa, A, additional, and Tursi, A, additional

Published
2024
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9. The practical management of chronic constipation as detected by a survey conducted on Italian gastroenterologists

Author

Fabbri, Carlo, Spada, Cristiano, Aragona, S. E., Ciprandi, Guido, Alberico, G., Antoniazzi, S., Arrigoni, A., Astegiano, M., Astretto, S., Baroni, S., Battaglia, E., Belcari, C., Beretta, P., Bianchetti, Maddalena, Bianchi, M. L., Bindi, B., Buda, C., Camilleri, S., Caronna, S., Cautela, G., Cavallaro, Fabio, Cocco, A., Colucci, R., Consalvo, D., Cordone, G., Cortelezzi, C., Cozzoli, G., Curro, E. A., Damiani, Andrea, D'Amore, F., De Falco, P., De Girolamo, Maria Vittoria, De Luca, L., Di Lorenzo, F., Di Marzo, S., Di Nardo, G., Ferrara, M., Fiaccavento, R., Fina, D., Frasca, R., Gallo, M., Gennarelli, N., Ghittoni, G., Giangregorio, F., Giannetti, A., Giglio, L. A., Giuncato, S., Grosso, S., Iannuzziello, D., Ibba, I., Incarbone, S., La Spada, S., Lagoussis, P., Lecca, G., Leonardi, G., Licari, G., Lucia, Mothanje Barbara Patricia, Lupinacci, G., Magri, S., Oppezzi, M., Paiano, P., Palombo, V., Pardocchi, D., Parodi, A., Pati, A., Petrini, C., Pinto, A., Pirrotta, P., Piscopo, A., Polimeni, N., Preatoni, P., Quintigliano, D., Radice, E., Ricco, G., Rodella, Luigi Fabrizio, Schettino, M., Schettino, Paola, Schicchi, A. A., Schiffino, L., Severi, C., Sinagra, E., Tarantello, M., Valeri, Giovanni, Vanni, R., Vinti, M., Zulli, C., Fabbri C., Spada C. (ORCID:0000-0002-5692-0960), Ciprandi G., Bianchetti M., Cavallaro F., Damiani A., De Girolamo V. (ORCID:0009-0003-4046-6454), Lucia M. (ORCID:0000-0001-7648-2198), Rodella L., Schettino P., Valeri G., Fabbri, Carlo, Spada, Cristiano, Aragona, S. E., Ciprandi, Guido, Alberico, G., Antoniazzi, S., Arrigoni, A., Astegiano, M., Astretto, S., Baroni, S., Battaglia, E., Belcari, C., Beretta, P., Bianchetti, Maddalena, Bianchi, M. L., Bindi, B., Buda, C., Camilleri, S., Caronna, S., Cautela, G., Cavallaro, Fabio, Cocco, A., Colucci, R., Consalvo, D., Cordone, G., Cortelezzi, C., Cozzoli, G., Curro, E. A., Damiani, Andrea, D'Amore, F., De Falco, P., De Girolamo, Maria Vittoria, De Luca, L., Di Lorenzo, F., Di Marzo, S., Di Nardo, G., Ferrara, M., Fiaccavento, R., Fina, D., Frasca, R., Gallo, M., Gennarelli, N., Ghittoni, G., Giangregorio, F., Giannetti, A., Giglio, L. A., Giuncato, S., Grosso, S., Iannuzziello, D., Ibba, I., Incarbone, S., La Spada, S., Lagoussis, P., Lecca, G., Leonardi, G., Licari, G., Lucia, Mothanje Barbara Patricia, Lupinacci, G., Magri, S., Oppezzi, M., Paiano, P., Palombo, V., Pardocchi, D., Parodi, A., Pati, A., Petrini, C., Pinto, A., Pirrotta, P., Piscopo, A., Polimeni, N., Preatoni, P., Quintigliano, D., Radice, E., Ricco, G., Rodella, Luigi Fabrizio, Schettino, M., Schettino, Paola, Schicchi, A. A., Schiffino, L., Severi, C., Sinagra, E., Tarantello, M., Valeri, Giovanni, Vanni, R., Vinti, M., Zulli, C., Fabbri C., Spada C. (ORCID:0000-0002-5692-0960), Ciprandi G., Bianchetti M., Cavallaro F., Damiani A., De Girolamo V. (ORCID:0009-0003-4046-6454), Lucia M. (ORCID:0000-0001-7648-2198), Rodella L., Schettino P., and Valeri G.

Abstract

BACKGROUND: Chronic constipation represents a widespread medical condition, mainly in elderly people. The management is compelling as these patients frequently have comorbidity and polypharmacy. Polyethylene glycol (PEG) is commonly used but does not resolve some complaints, mainly concerning pain and bloating. Therefore, a new medical device containing PEG plus simethicone, an antifoaming agent, has been developed. The present survey explored its use in clinical practice. METHODS: A group of 64 Italian gastroenterologists visited 2426 patients with chronic primary constipation. In about two/third, gastroenterologists freely prescribed the new medical device, and in the remaining patients, other treatments were freely chosen by doctors. Patients were followed up for three months. The number of evacuations, stool characteristics, patients’ perception of illness assessed by VAS, frequency of patients with pain and intestinal symptoms, and discontinuing patients was observed during the experience. RESULTS: The new medical device was significantly better than other therapies in improving all parameters (P<0.05 for all parameters). CONCLUSIONS: The present survey demonstrated that a new medical device containing PEG plus simethicone represents a favorable option in managing patients with chronic primary constipation as significantly and safely improves intestinal transit, reduces stool consistency, reduces symptom severity, and is highly satisfactory.

Published
2023

11. T.06.8 REAL WORD LONG-TERM EFFICACY AND SAFETY OF VEDOLIZUMAB IN MANAGING ULCERATIVE COLITIS VERSUS CROHN'S DISEASE: RESULTS FROM “LONG VEDO” ITALIAN MULTICENTER STUDY

Author

Mocci, G., primary, Maconi, G., additional, Cataletti, G., additional, Mantia, B., additional, Serio, M., additional, Scarcelli, A., additional, Onidi, F.M., additional, Pagnini, C., additional, Graziani, M., additional, Di Paolo, M., additional, Pranzo, G., additional, Luppino, I., additional, Paese, P., additional, Monterubbianesi, R., additional, Faggiani, R., additional, Ferronato, A., additional, Perini, B., additional, Savarino, E., additional, Binaghi, L., additional, Schiavoni, E., additional, Napolitano, D., additional, Scaldaferri, F., additional, Papa, A., additional, Lorenzetti, R., additional, Pica, R., additional, Cocco, A., additional, Rodino, S., additional, Sebkova, L., additional, Zampaletta, C., additional, Gaiani, F., additional, Fanigliulo, L., additional, Allegretta, L., additional, Cuomo, A., additional, Donnarumma, L., additional, Della Valle, N., additional, Forti, G., additional, Dore, M., additional, Antonelli, E., additional, Bassotti, G., additional, Iannelli, C., additional, Aragona, G., additional, Lauria, A., additional, Piergallini, S., additional, Colucci, R., additional, Meucci, C., additional, Usai Satta, P., additional, Elisai, W., additional, and Tursi, A., additional

Published
2023
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12. P505 Real word long-term efficacy and safety of vedolizumab in managing ulcerative colitis versus crohn’s disease: results from “long vedo” italian multicenter study

Author

Mocci, G, primary, Maconi, G, additional, Onidi, F M, additional, Cataletti, G, additional, Elisei, W, additional, Scaldaferri, F, additional, Lorenzetti, R, additional, Pagnini, C, additional, Scarcelli, A, additional, Graziani, M G, additional, Di Paolo, M C, additional, Pranzo, G, additional, Luppino, I, additional, Monterubbianesi, R, additional, Faggiani, R, additional, Ferronato, A, additional, Savarino, E, additional, Pica, R, additional, Cocco, A, additional, Rodino, S, additional, Sebkova, L, additional, Zampaletta, C, additional, Gaiani, F, additional, Fanigliulo, L, additional, Allegretta, L, additional, Cuomo, A, additional, Donnarumma, L, additional, Della Valle, N, additional, Forti, G, additional, Antonelli, E, additional, Bassotti, G, additional, Iannelli, C, additional, Aragona, G, additional, Lauria, A, additional, Piergallini, S, additional, Colucci, R, additional, Binaghi, L, additional, Meucci, C, additional, Papa, A, additional, and Tursi, A, additional

Published
2023
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13. Compression therapy, autonomic nervous system, and heart rate variability: A narrative review and our preliminary personal experience

Author

Cavezzi A, Colucci R, Barsotti N, and Di Ionna G

Subjects
Cross-Over Studies, Heart Rate, Humans, General Medicine, Cardiology and Cardiovascular Medicine, Autonomic Nervous System
Abstract

Aims To highlight the relationship among compression therapy (CT), the autonomic nervous system (ANS) (parasympathetic and sympathetic system), and the heart rate variability (HRV) analysis. Background Beyond the typical analgesic and anti-inflammatory effects of CT in patients affected by venous and/or lymphatic diseases, some literature about CT influence on wellbeing has been published as well. More specifically, CT influence on the ANS has been elucidated mostly through HRV application, providing useful quali-quantitative data for scientific and clinical purposes. Material and Methods A literature search was performed through several web-based search engines to investigate the available evidence concerning the possible influence of CT on the ANS and on psychoneuroendocrineimmunology. Moreover, we examined literature data regarding HRV use in the assessment of CT. Lastly, a preliminary cross-over study was performed on 10 patients affected by phlebolymphedema of the lower limbs, undergoing CT with 18–21 mmHg stockings for 10 h and investigated by means of HRV. Results A CT-based increase of the anti-inflammatory activity of the parasympathetic (vagal) system has been elucidated in most scientific literature. Similarly, CT application has generally resulted in an improvement of HRV, which indicates a beneficial influence on the ANS. In our preliminary experience with compression stockings and HRV, two parasympathetic-based parameters improved by 22.8% and 68.0% after 10 h, whereas they decreased in the same subjects without stockings by 2.7% and 8.2%, during normal breathing. The remaining HRV parameters did not show relevant variations, especially during diaphragmatic breathing. Conclusions From literature data and based on our very preliminary experience, it is possible to deduce that CT exerts different effects on the psychobiological parameters of the individual, overall improving HRV and parasympathetic activity. Incorporating both HRV/ANS assessment in phlebolymphology and the beneficial neural action of CT in health care may represent viable options in the future biomedical science.

Published
2022

17. Comparison of performances of infliximab biosimilars CT-P13 versus SB2 in the treatment of inflammatory bowel diseases: a real-life multicenter, observational study in Italy

Author

Tursi, Antonio, Mocci, G., Allegretta, L., Aragona, G., Bianco, M. A., Colucci, R., Cuomo, A., Della Valle, N., Ferronato, A., Forti, G., Gaiani, F., Graziani, M. G., Lorenzetti, R., Luzza, F., Paese, P., Penna, A., Pica, R., Pranzo, G., Rodino, S., Scarcelli, A., Zampaletta, C., Brozzi, L., Cicerone, C., Cocco, A., De' Angelis, G., Donnarumma, L., Fiorella, S., Iannelli, C., Larussa, T., Le Grazie, M., Luppino, I., Meucci, C., Faggiani, R., Pagnini, C., Perazzo, P., Rodriguez-Castro, K. I., Sacco, R., Sebkova, L., Serio, M., De Monti, A., Picchio, M., Napolitano, Daniele, Schiavoni, Elisa, Turchini, Laura, Scaldaferri, Franco, Pugliese, Daniela, Guidi, Luisa, Laterza, Lucrezia, Privitera, G., Pizzoferrato, M., Lopetuso, Loris Riccardo, Armuzzi, Alessandro, Elisei, W., Maconi, G., Papa, Alfredo, Tursi A., Napolitano D., Schiavoni E., Turchini L., Scaldaferri F. (ORCID:0000-0001-8334-7541), Pugliese D., Guidi L. (ORCID:0000-0003-3320-7094), Laterza L., Lopetuso L. R., Armuzzi A. (ORCID:0000-0003-1572-0118), Papa A. (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, G., Allegretta, L., Aragona, G., Bianco, M. A., Colucci, R., Cuomo, A., Della Valle, N., Ferronato, A., Forti, G., Gaiani, F., Graziani, M. G., Lorenzetti, R., Luzza, F., Paese, P., Penna, A., Pica, R., Pranzo, G., Rodino, S., Scarcelli, A., Zampaletta, C., Brozzi, L., Cicerone, C., Cocco, A., De' Angelis, G., Donnarumma, L., Fiorella, S., Iannelli, C., Larussa, T., Le Grazie, M., Luppino, I., Meucci, C., Faggiani, R., Pagnini, C., Perazzo, P., Rodriguez-Castro, K. I., Sacco, R., Sebkova, L., Serio, M., De Monti, A., Picchio, M., Napolitano, Daniele, Schiavoni, Elisa, Turchini, Laura, Scaldaferri, Franco, Pugliese, Daniela, Guidi, Luisa, Laterza, Lucrezia, Privitera, G., Pizzoferrato, M., Lopetuso, Loris Riccardo, Armuzzi, Alessandro, Elisei, W., Maconi, G., Papa, Alfredo, Tursi A., Napolitano D., Schiavoni E., Turchini L., Scaldaferri F. (ORCID:0000-0001-8334-7541), Pugliese D., Guidi L. (ORCID:0000-0003-3320-7094), Laterza L., Lopetuso L. R., Armuzzi A. (ORCID:0000-0003-1572-0118), and Papa A. (ORCID:0000-0002-4186-7298)

Published
2022

18. T.06.4 LONG TERM EFFICACY AND SAFETY OF ABP 501 ADALIMUMAB BIOSIMILAR ON INFLAMMATORY BOWEL DIESASES: THE ADASWITCH STUDY

Author

Cingolani, A., primary, Felice, C., additional, Lombardi, G., additional, Onidi, F.M., additional, Checchin, D., additional, Colucci, R., additional, Grossi, L., additional, Ferronato, A., additional, Rocchi, C., additional, Ascolani, M., additional, Binaghi, L., additional, Dore, M.F., additional, Fanini, L., additional, Bulajic, M., additional, and Mocci, G., additional

Published
2022
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19. T.07.10 PERFORMANCE OF A MULTI-COMPOUNDS NUTRACEUTICAL FORMULATION IN PATIENTS WITH SYMPTOMATIC UNCOMPLICATED DIVERTICULAR DISEASE

Author

Gravina, A.G., primary, Brandimarte, G., additional, Frajese, G.V., additional, Bargiggia, S., additional, Castellani, D., additional, Cocco, A., additional, Colucci, R., additional, Evangelista, E., additional, Napoletano, D., additional, Nardi, E., additional, Maisto, T., additional, Morabito, A., additional, Pianese, G., additional, Romano, A., additional, Sacco, R., additional, Sinnona, N., additional, Sediari, L., additional, Tifi, L., additional, Davino, A., additional, Elisei, W., additional, and Tursi, A., additional

Published
2022
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22. Predictive value of the “DICA” classification on the outcome of diverticular disease of the colon: an international study: 3.14

Author

Tursi, A., Brandimarte, G., Di Mario, F., Annunziata, M. L., Bafutto, M., Bianco, M. A., Colucci, R., Conigliaro, R., Danese, S., De Bastiani, R., Elisei, W., Escalante, R., Faggiani, R., Ferrini, L., Forti, G., Latella, G., Graziani, M. G., Oliveira, E., Papa, A., Penna, A., Søreide, K., Spadaccini, A., Usai, P., Zampaletta, C., Cassieri, C., Desserud, K. F., Fiorella, S., Landi, R., Goni, E., Lai, M. A., Pigò, F., Scarpignato, C., Picchio, M., Scaccianoce, G., and Portincasa, P.

Published
2016

23. P398 Long term efficacy and safety of ABP, 501 adalimumab biosimilar in inflammatory bowel diseases: preliminary results from the ADASWITCH study

Author

Cingolani, A, primary, Felice, C, additional, Lombardi, G, additional, Onidi, F M, additional, Checchin, D, additional, Colucci, R, additional, Grossi, L, additional, Ferronato, A, additional, Rocchi, C, additional, Ascolani, M, additional, Binaghi, L, additional, Dore, M F, additional, Fanini, L, additional, Bulajic, M, additional, and Mocci MD FRCP, G, additional

Published
2022
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25. Predictive value of the ‘DICA’ classification on the outcome of diverticular disease of the colon: 2.14

Author

Tursi, A., Brandimarte, G., Di Mario, F., Annunziata, M. L., Bianco, M. A., Conigliaro, R., Elisei, W., Faggiani, R., Forti, G., Lecca, P. G., Penna, A., Spadaccini, A., Zampaletta, C., Colucci, R., De Bastiani, R., Di Cesare, L., Di Fonzo, M., Goni, E., Ferrini, L., Graziani, M. G., Latella, G., Pigò, F., Rotondano, G., Schiaccianoce, G., Picchio, M., Scarpignato, C., and Portincasa, P.

Published
2015

32. P583 Real-life efficacy and safety of Ustekinumab as second- or third-line therapy in Crohn’s disease: results from a large Italian cohort study

Author

Mocci, G, primary, Cuomo, A, additional, Allegretta, L, additional, Aragona, G, additional, Colucci, R, additional, Della Valle, N, additional, Ferronato, A, additional, Forti, G, additional, Gaiani, F, additional, Graziani, M G, additional, Lorenzetti, R, additional, Luzza, F, additional, Penna, A, additional, Pica, R, additional, Piergallini, S, additional, Rodinò, S, additional, Scarcelli, A, additional, Zampaletta, C, additional, Cicerone, C, additional, Cocco, A, additional, De Angelis, G, additional, Donnarumma, L, additional, Pranzo, G, additional, Franceschi, M, additional, Gallina, S, additional, Grasso, G, additional, Larussa, T, additional, Luppino, I, additional, Faggiani, R, additional, Fanigliulo, L, additional, Pagnini, C, additional, Perazzo, P, additional, Sacco, R, additional, Sebkova, L, additional, Serio, M E, additional, De Monti, A, additional, Picchio, M, additional, Elisei, W, additional, Maconi, G, additional, and Tursi, A, additional

Published
2021
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33. Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice

Author

Fornai, M., Blandizzi, C., Colucci, R., Antonioli, L., Benardini, N., Segnani, C., Baragatti, B., Barogi, S., Bert, P., Spisni, R., and Del Tacca, M.

Subjects
Muscle contraction -- Research, Cyclooxygenases -- Research, Cyclooxygenases -- Genetic aspects, Colon (Anatomy) -- Research, Colon (Anatomy) -- Genetic aspects, Animal experimentation -- Research, Health
Published
2005

37. Correction: Lactiplantibacillus plantarum HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis.

Author

Di Salvo, C., D'Antongiovanni, V., Benvenuti, L., d'Amati, A., Ippolito, C., Segnani, C., Pierucci, C., Bellini, G., Annese, T., Virgintino, D., Colucci, R., Antonioli, L., Fornai, M., Errede, M., Bernardini, N., and Pellegrini, C.

Published
2024
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40. Ice Caves in Italy - Chapter 19

Author

Aurel Perşoiu, Stein-Erik Lauritzen, Maggi, V, Colucci, R, Scoto, F, Giudice, G, Randazzo, L, Colucci,R, Aurel Perşoiu, Stein-Erik Lauritzen, Maggi, V, Colucci, R, Scoto, F, Giudice, G, Randazzo, L, and Colucci,R

Abstract

In Italy, more than 1600 caves are classified as cryo-caves, due to the presence of multiyear snow, firn, or ice. Previous regional studies show that at least 10% of such caves can be included in the ice cave classification, because they have a perennial ice deposit. However, the strong differences in the karstological characteristics of the Italian geology allows having not only caves formed in limestone, dolomite, or marble terrains, in the Alps as well as in the Apennines, but also in lava tubes on the Etna Volcano. Four ice caves are reported here as examples of three different mechanisms of ice cave formation and evolution. From Grigna Settentrionale, central Alps, a vertical shaft ice deposit mainly formed by dripping water was studied by chemical and stable isotope record. Two high altitude ice caves originated by snow accumulation and ice dipping were studied in the Canin massif, southeastern Alps, and a lava tube from Etna volcano was studied for its ice dynamics and air-circulation mechanisms. These four examples provide important data on the evolution of such ice deposits, giving a first clue on their progressive reduction under recent climate forcing

Published
2018

47. Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being

Author

Guaitolini, E., Cavezzi, A., STEFANIA COCCHI, Colucci, R., Urso, S. U., and Quinzi, V.

Subjects
Original Research
Abstract

Objective: The purpose of this study was to evaluate the efficacy and safety of a multicomponent nutraceutical (MCN) on facial skin. Methods: A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging. For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo. At Day 0 (T0) and Day 60 (T60), face skin hydration, elasticity, and sebometry were measured with an instrumental skin tester, and digital images of facial wrinkles were scored. A subject-based quali-/ quantitative assessment evaluating satisfaction/ quality of life was performed at T60. Results: The MCN and placebo groups each included 25 volunteers (mean ages: 49.3 and 47.8 years, respectively). After 60 days of MCN intake, glabella skin hydration and elasticity improved by 15.2 percent and 22.6 percent, respectively (p=0.03; p=0.004), glabella sebaceous secretion decreased by 24.2 percent (p=0.01), skin hydration and elasticity of the periocular area increased by 12.6 percent and 15.9 percent, respectively, and skin hydration and elasticity of the oral commissural area increased by 17.6 percent and 16 percent, respectively (p

Published
2019

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