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The association between current smoking and coronavirus disease 2019 (COVID-19) progression remains uncertain. We aim to provide up-to-date evidence of the role of cigarette smoking in COVID-19 hospitalisation, severity and mortality. On 23 February 2022 we conducted an umbrella review and a traditional systematic reviewviaPubMed/Medline and Web of Science. We used random-effects meta-analyses to derive pooled odds ratios of COVID-19 outcomes for smokers in cohorts of severe acute respiratory syndrome coronavirus 2 infected individuals or COVID-19 patients. We followed the Meta-analysis of Observational Studies in Epidemiology reporting guidelines. PROSPERO: CRD42020207003. 320 publications were included. The pooled odds ratio for currentversusnever or nonsmokers was 1.08 (95% CI 0.98–1.19; 37 studies) for hospitalisation, 1.34 (95% CI 1.22–1.48; 124 studies) for severity and 1.32 (95% CI 1.20–1.45; 119 studies) for mortality. Estimates for formerversusnever-smokers were 1.16 (95% CI 1.03–1.31; 22 studies), 1.41 (95% CI: 1.25–1.59; 44 studies) and 1.46 (95% CI 1.31–1.62; 44 studies), respectively. Estimates for ever-versusnever-smokers were 1.16 (95% CI 1.05–1.27; 33 studies), 1.44 (95% CI 1.31–1.58; 110 studies) and 1.39 (95% CI 1.29–1.50; 109 studies), respectively. We found a 30–50% excess risk of COVID-19 progression for current and former smokers compared with never-smokers. Preventing serious COVID-19 outcomes, including death, seems the newest compelling argument against smoking.

Temporary prosthesis protects the oral tissues, in addition to providing aesthetic look and masticatory function until a definitive prosthesis is manufactured.To evaluate the effect of glaze and 0.12% chlorhexidine (CHX) on the physical and mechanical properties of bis-acryl, and to evaluate the antimicrobial efficacy of CHX.Eighty specimens of bis-acryl resin were made. Over 40 of them the glaze was applied. One specimen with and 1 specimen without glaze were placed in niches of an appliance manufactured for each patient. Each of the 20 volunteers received 2 devices. Initially, the volunteers used one device and treated it with sucrose for 7 days (control), and later they used the other device and treated it with sucrose and CHX for 7 days (test). Color, microhardness, roughness, surface energy, and insoluble extracellular polysaccharides (EPS) tests were performed. All results were submitted to the Tukey's test, with the exception of the EPS results, which were submitted to the Student's t test.The ΔE00 of the unglazed control group was significantly higher than that of the unglazed test group. In all groups, a significant decrease in microhardness occurred over time. At both times, the glaze significantly increased the microhardness of the specimens (in all the glazed groups). At the final time, the test glaze group showed significantly higher microhardness compared with the control glaze group. Roughness in the groups without glaze increased significantly with CHX treatment over time. At both times, the glaze generated a significant reduction in roughness in the control and test groups. There was a significant reduction in surface energy over time in all groups. In most comparisons, the glazed groups showed significantly higher surface energy values compared with the unglazed control group. At the final time point, the unglazed test group showed a significantly higher surface energy value than the unglazed control group; and the glazed test group showed a significantly higher surface energy value compared with the glazed control group. The resins that received CHX had a significantly lower amount of biofilm.Color values were clinically acceptable in all tested groups. At both time points, the roughness values were clinically acceptable only in the glazed groups. Glaze increased the microhardness of the specimens. Microhardness and surface energy were reduced over time in all groups. Chlorhexidine can help prevent microhardness degradation. Glaze and CHX can increase surface energy. Chlorhexidine reduced the amount of bacterial biofilm.

Summary: Background: There are concerns that the use of electronic nicotine delivery systems (ENDS) and electronic non-nicotine delivery systems (ENNDS) in children and adolescents could potentially be harmful to health. Understanding the extent of use of these devices is crucial to informing public health policy. We aimed to synthesise the prevalence of ENDS or ENNDS use in children and adolescents younger than 20 years. Methods: In this systematic review and meta-analysis, we undertook an electronic search in five databases (MEDLINE, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Embase, and Wiley Cochrane Library) from Jan 1, 2016, to Aug 31, 2020, and a grey literature search. Included studies reported on the prevalence of ENDS or ENNDS use in nationally representative samples in populations younger than 20 years and collected data between the years 2016 and 2020. Studies were excluded if they were done in those aged 20 years or older, used data from specialist panels that did not apply appropriate weighting, or did not use methods that ensured recruitment of a nationally representative sample. We included the most recent data for each country. We combined multiple national estimates for a country if they were done in the same year. We undertook risk of bias assessment for all surveys included in the review using the Joanna Briggs Institute Critical Appraisal Checklist (by two reviewers in the author list). A random effects meta-analysis was used to pool overall prevalence estimates for ever, current, occasional, and daily use. This study was prospectively registered with PROSPERO, CRD42020199485. Findings: The most recent prevalence data from 26 national surveys representing 69 countries and territories, with a median sample size of 3925 (IQR 1=2266, IQR 3=10 593) children and adolescents was included. In children and adolescents aged between 8 years and younger than 20 years, the pooled prevalence for ever (defined as any lifetime use) ENDS or ENNDS use was 17·2% (95% CI 15–20, I2=99·9%), whereas for current use (defined as use in past 30 days) the pooled prevalence estimate was 7·8% (6–9, I2=99·8%). The pooled estimate for occasional use was 0·8% (0·5–1·2, I2=99·4%) for daily use and 7·5% (6·1–9·1, I2=99·4%) for occasional use. Prevalence of ENDS or ENNDS use was highest in high-income geographical regions. In terms of study quality, all surveys scored had a low risk of bias for the sampling frame used, due to the nationally representative nature of the studies. The most poorly conducted methodological feature of the included studies was subjects and setting described in detail. Few surveys reported on the use of flavours or types of ENDS or ENNDS. Interpretation: There is significant variability in the prevalence of ENDS and ENNDS use in children and adolescents globally by country income status. These findings are possibly due to differences in regulatory context, market availability, and differences in surveillance systems. Funding: World Health Organization and the Bill & Melinda Gates Foundation.

Introduction: Female Breast cancer is the second leading cause of cancer-related deaths in the U.S. While the incidence rate is lower in Hispanic-Black, the mortality rate is higher compared to Non-Hispanic White. This study investigates the trends of incidence and mortality rate of breast cancer in the U.S.: 2000-2016. It further explores the racial disparities between these two races. Method: Data for four age groups (15 - 39 yrs, 40 - 64 yrs, 65 - 74 yrs, 75+ yrs) of Hispanic-Black and Non-Hispanic White women for breast cancer were extracted from SEER; age-adjusted rate (U.S. 2000 standard population). Primary trend analysis was done with PyCharm 2020.3.3. (line charts) and regression models to check any significant increase or decrease over the years were done with JoinPoint 4.8.0.1 (APC, 95% CI, significant p-value: Result: Incidence rate is higher in Non-Hispanic White women, whereas mortality rate is higher in Hispanic Black. The 40 - 64 yrs age groups showed an increase in incidence rate for Hispanic Black women, whereas an decrease for White women. The least vulnerable group, 15 - 39 yrs age showed an increase in incidence rate in Non-Hispanic White women. The mortality rate was declining overall for both races. Conclusion: Disparities in oncologic healthcare, insurance system and socio-economic factors are possibly responsible for the higher mortality in Black American women. Improvements in these factors may reduce racial differences.

The aim of this study was to compare the use of titanium and ceramic implants for overdentures in terms of their failure rates, surface treatments, and marginal bone loss (MBL). The literature was searched using the PubMed, Scopus, and Cochrane databases up to October 2019. Clinical studies in which ceramic and titanium implants for overdentures were compared in terms of their failure rates, surface treatments, and MBL were included in the meta-analysis. The meta-analysis was performed based on the Mantel-Haenszel and inverse variance methods using a fixed-effects model and 95% confidence intervals. A total of 2747 publications were identified after the exclusion of duplicate articles. Fifteen were selected for full-text reading, and 2 were included in the review. Each of the 2 studies initially enrolled 24 patients, and a total of 38 patients (mean age of 62 years) were evaluated at the 1-year follow-up. A total of 112 titanium implants (success rate of 71.1%) and 146 ceramic implants (success rate of 65.9%) were placed. Twenty titanium implants failed, and an associated MBL of 0.15 mm was observed. For ceramic implants, 42 failures occurred, and an associated MBL of 0.33 mm was observed. Titanium implants provided better clinical results (less MBL and lower failure rate) for the support of overdentures than did ceramic implants.

Entender o comportamento hidrológico de bacias é algo complexo, em contrapartida, os modelos hidrológicos são ferramentas cujo objetivo é de representar o ciclo hidrológico em grandes áreas. Uma ferramenta que vem auxiliando no desenvolvimento de modelos hidrológicos de larga escala é o uso de SIG, em que auxilia na análise de solo, cobertura e relevo, de tal forma que se consiga um entendimento mais completo dos processos das bacias hidrográficas. Neste estudo, foi aplicado o modelo MGB-IPH na bacia do Alto Taquari, e teve como objetivo calibrar o modelo hidrológico, e posteriormente, testar combinações de cenários futuros de mudança climática e uso e ocupação do solo e afim de detectar mudanças em variáveis hidrológicas. Os resultados da calibração foram aceitáveis, com o valor de NS de 0,64 no exutório da bacia e as simulações das projeções indicaram a diminuição da vazão média mensal para grande parte dos cenários possibilitando traçar tendências para uma melhor tomada de decisão no que tange a gestão da bacia hidrográfica.

This in-situ study aimed to evaluate the chromatic stability, microhardness, and surfacefree energy of chemically activated acrylic resin (CAAR) samples. Eighty CAAR samples were made and each volunteer (n = 20) received two palatal plates with two sides of groups (without and with glaze application). The samples were exposed to two conditions: the control condition (sucrose 30%) and the test condition (sucrose 30% and 0.12% chlorhexidine). The volunteers used the first palatal device (control condition) for seven days and the second palatal device (test condition) for another seven days, with a seven-day break between them. Then, the ΔΕ00, microhardness, and surface-free energy tests were performed. Analysis of Variance and the Tukey test were used (α = 0.05). The control group with glaze showed higher ΔΕ00 compared to the group without the glaze. The test group with glaze had less ΔΕ00 than their respective controls. In both periods, when the glaze was applied, higher microhardness values were found for all groups. Groups with glaze showed lower roughness and higher surface-free energy than groups without the glaze. The values obtained in this study were satisfactory, showing the clinical efficacy of glaze and the use of 0.12% CH for maintaining the physical and mechanical properties of CAAR.

Background: This systematic review described the association between electronic nicotine delivery systems and electronic non-nicotine delivery systems (ENDS/ENNDS) use among non-smoking children and adolescents aged

Background This systematic review described the association between electronic nicotine delivery systems and electronic non-nicotine delivery systems (ENDS/ENNDS) use among non-smoking children and adolescents aged Methods We searched five electronic databases and the grey literature up to end of September 2020. Prospective longitudinal studies that described the association between ENDS/ENNDS use, and subsequent tobacco use in those aged < 20 years who were non-smokers at baseline were included. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess risk of bias. Data were extracted by two reviewers and pooled using a random-effects meta-analysis. We generated unadjusted and adjusted risk ratios (ARRs) describing associations between ENDS/ENNDS and tobacco use. Findings A total of 36 publications met the eligibility criteria, of which 25 were included in the systematic review (23 in the meta-analysis) after exclusion of overlapping studies. Sixteen studies had high to moderate risk of bias. Ever users of ENDS/ENNDS had over three times the risk of ever cigarette use (ARR 3·01 (95% CI: 2·37, 3·82; p2: 82·3%), and current cigarette use had over two times the risk (ARR 2·56 (95% CI: 1·61, 4·07; p2: 77·3%) at follow up. Among current ENDS/ENNDS users, there was a significant association with ever (ARR 2·63 (95% CI: 1·94, 3·57; p2: 21·2%)), but not current cigarette use (ARR 1·88 (95% CI: 0·34, 10·30; p = 0·47, I2: 0%)) at follow up. For other tobacco use, ARR ranged between 1·55 (95% CI 1·07, 2·23) and 8·32 (95% CI: 1·20, 57·04) for waterpipe and pipes, respectively. Additionally, two studies examined the use of ENNDS (non-nicotine devices) and found a pooled adjusted RR of 2·56 (95% CI: 0·47, 13·94, p = 0.035). Conclusion There is an urgent need for policies that regulate the availability, accessibility, and marketing of ENDS/ENNDS to children and adolescents. Governments should also consider adopting policies to prevent ENDS/ENNDS uptake and use in children and adolescents, up to and including a ban for this group.

Fundação de Amparo à Pesquisa do Estado de Minas Gerais Em uma das fronteiras agrícolas mais ativas do mundo encontra-se a região Oeste da Bahia, que apresenta diversos fatores favoráveis ao desenvolvimento do agronegócio. Porém por ser localizada em uma região de transição entre o clima sazonal do Cerrado e o semiárido possui limitação em chuvas, o que desencadeou para região um avanço de áreas irrigadas, provocando conflitos sobre os recursos hídricos. O presente estudo teve como objetivo avaliar previsões hidroclimáticas para o início da estação chuvosa (Ic) no Oeste da Bahia utilizando previsões de chuva do modelo climático de circulação geral da atmosfera CFSv2 e dados de precipitação dos produtos TRMM 3B42 e PERSIANN. Para isto foram calculadas a data de início da estação chuvosa para as três bases de dados e métricas de acurácia como MAE e Erro Médio para avaliar a acurácia das previsões de chuva do CFSv2 em relação aos dados observados. Os resultados mostraram que a acurácia das estimativas de Ic pelo CFSv2 possuem um gradiente no sentido oeste-leste da região e que dependem fortemente da data de inicialização das previsões hidroclimáticas. Os resultados também indicaram que com dois meses de antecedência o CFSv2 apresenta um MAE com 15 a 20 dias de diferença para os dados observados. Porém o CFSv2 demonstrou uma inconsistência maior para o extremo leste do Oeste da Bahia. Os testes de acurácia também evidenciaram que em anos de El Niño o CFSv2 tem um MAE de 2 a 8 dias maiores que para média analisada. Concluiu-se que a previsão hidroclimática pelo CFSv2 tem capacidade de dar suporte aos tomadores de decisão na região Oeste da Bahia, contribuindo para um uso mais eficiente dos recursos hídricos na região. No entanto, destaca-se que a previsão hidroclimática para esta região ainda carece de aprimoramentos, como modelos de maior resolução e com volumes de chuvas mais precisos. Palavras-chave: Estação chuvosa. CFSv2. Previsão hidroclimática. Oeste da Bahia. El Niño. In one of the most active agricultural frontiers in the world is the western region of Bahia, which presents several factors favorable to the development of agribusiness. However, because it is located in a transition region between the seasonal climate of the Cerrado and the semi-arid region, it has limited rainfall, which has triggered an advance of irrigated areas for the region, causing conflicts over water resources. The present study aimed to evaluate hydroclimatic forecasts for the onset of the rainy season (Ic) in western Bahia using rain forecasts of the general circulation model CFSv2 and rainfall data of products TRMM 3B42 and PERSIANN. For this, the onset of the rainy season was calculated for the three databases and accuracy metrics such as MAE and Mean Error to evaluate the accuracy of the rainfall forecasts of CFSv2 in relation to the observed data. The results showed that the accuracy of the Ic estimates by CFSv2 has a gradient in the west-east direction of the region and that they depend heavily on the initialization lead of the hydroclimatic forecasts. The results also indicated that two months in advance, CFSv2 presents a MAE with 15 to 20 days difference for the observed data. However, the CFSv2 demonstrated a greater inconsistency to the extreme east of western Bahia. The accuracy tests also showed that in El Niño years the CFSv2 has a MAE of 2 to 8 days higher than for the average analyzed. It was concluded that the hydroclimatic forecast by CFSv2 has the capacity to support decision makers in the Western region of Bahia, contributing to a more efficient use of water resources in the region. However, it is noteworthy that the hydroclimatic forecast for this region still lacks improvements, such as models with higher resolution and more accurate rainfall volumes. Keywords: Rainy season. CFSv2. Hydroclimatic forecast. Western Bahia. El Niño.

Made available in DSpace on 2021-06-25T10:57:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Statement of problem: The use of 0.12% chlorhexidine gluconate (CHX) may damage bisacrylate composite resin interim restorations, but whether they can be protected with an application of alcohol and/or the use of a glaze is unclear. Purpose: The purpose of this in vitro study was to evaluate the effect of applying a 70% alcohol solution on the physical and mechanical properties of a bisacrylate composite resin, with and without the application of a light-polymerizing glaze subjected to 0.12% CHX twice a day for 7 days. Material and methods: Forty specimens of an autopolymerized bisacrylate composite resin were divided into 4 groups (n=10): Group C (without alcohol, without glaze), Group G (without alcohol, with glaze), Group A (with alcohol, without glaze), and Group AG (with alcohol, with glaze). All specimens were submitted to in vitro treatment with 0.12% CHX for 7 days, and tests of color alteration (ΔE00), microhardness, roughness, and surface were performed initially and after treatment. Data were submitted to analysis of variance (ANOVA) and the Tukey HSD test (α=.05). Results: Group A had the lowest mean value of ΔE00 with a significant statistical difference from Group C. The groups with alcohol presented higher microhardness mean values compared with groups without alcohol in both periods of analysis, except for the groups with glaze in the final period. Group C showed higher mean roughness values in comparison with Group A in both periods. Group AG presented higher mean roughness values than Group G. Surface energy values did not vary significantly among groups, except between Groups C and A in the final period. Conclusions: The application of alcohol optimized the properties of the autopolymerized bisacrylate composite resin analyzed, with and without the application of glaze. Overall, the use of CHX changed the microhardness and roughness when the glaze was applied. Graduate student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Post-doctoral student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Undergraduate student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Professor Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Graduate student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Post-doctoral student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Undergraduate student Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP) Professor Department of Dental Materials and Prosthodontics Aracatuba Dental School Sao Paulo State University (UNESP)

Each year, tobacco use causes approximately 7 million deaths worldwide, including approximately 6 million among tobacco users and an estimated 890,000 among nonsmokers exposed to secondhand smoke (1). Tobacco use is a leading preventable cause of disease globally and has been determined to cause adverse health outcomes such as coronary heart disease, stroke, and multiple types of cancer, including lung cancer (2-4). Approximately 80% of the world's 1.1 billion tobacco smokers reside in low- and middle-income countries (4). Some persons do not fully understand the health risks associated with tobacco smoking (5-9), and studies have indicated that increasing knowledge about the adverse health effects of smoking can contribute to decreases in smoking, increases in cessation attempts, and increases in successful cessation (3,7,10). CDC analyzed 2008-2016 Global Adult Tobacco Survey (GATS) data from 28 countries to assess tobacco smoking prevalence, quit attempts, and knowledge about tobacco smoking risks among persons aged ≥15 years. Across countries, the median prevalence of tobacco smoking was 22.5%, and a median of 42.5% of tobacco smokers had made a quit attempt in the preceding 12 months. The median prevalences of knowing that tobacco smoking causes stroke, heart attack, and lung cancer were 73.6%, 83.6%, and 95.2%, respectively. Implementation of proven tobacco control interventions, including strategies that increase knowledge about the health risks posed by tobacco use, might help to reduce tobacco use and tobacco-related disease, including heart disease, stroke, and lung cancer (3-5).

Summary Background The WHO Framework Convention on Tobacco Control (WHO FCTC) has mobilised efforts among 180 parties to combat the global tobacco epidemic. This study examined the association between highest-level implementation of key tobacco control demand-reduction measures of the WHO FCTC and smoking prevalence over the treaty's first decade. Methods We used WHO data from 126 countries to examine the association between the number of highest-level implementations of key demand-reduction measures (WHO FCTC articles 6, 8, 11, 13, and 14) between 2007 and 2014 and smoking prevalence estimates between 2005 and 2015. McNemar tests were done to test differences in the proportion of countries that had implemented each of the measures at the highest level between 2007 and 2014. Four linear regression models were computed to examine the association between the predictor variable (the change between 2007 and 2014 in the number of key measures implemented at the highest level), and the outcome variable (the percentage point change in tobacco smoking prevalence between 2005 and 2015). Findings Between 2007 and 2014, there was a significant global increase in highest-level implementation of all key demand-reduction measures. The mean smoking prevalence for all 126 countries was 24·73% (SD 10·32) in 2005 and 22·18% (SD 8·87) in 2015, an average decrease in prevalence of 2·55 percentage points (SD 5·08; relative reduction 10·31%). Unadjusted linear regression showed that increases in highest-level implementations of key measures between 2007 and 2014 were significantly associated with a decrease in smoking prevalence between 2005 and 2015). Each additional measure implemented at the highest level was associated with an average decrease in smoking prevalence of 1·57 percentage points (95% CI −2·51 to −0·63, p=0·001) and an average relative decrease of 7·09% (−12·55 to −1·63, p=0·011). Controlling for geographical subregion, income level, and WHO FCTC party status, the per-measure decrease in prevalence was 0·94 percentage points (−1·76 to −0·13, p=0·023) and an average relative decrease of 3·18% (−6·75 to 0·38, p=0·079). This association was consistent across all three control variables. Interpretation Implementation of key WHO FCTC demand-reduction measures is significantly associated with lower smoking prevalence, with anticipated future reductions in tobacco-related morbidity and mortality. These findings validate the call for strong implementation of the WHO FCTC in the WHO's Global Action Plan for the Prevention and Control of Non-communicable Diseases 2013–2020, and in advancing the UN's Sustainable Development Goal 3, setting a global target of reducing tobacco use and premature mortality from non-communicable diseases by a third by 2030. Funding Health Canada, Canadian Institutes of Health Research, Ontario Institute for Cancer Research and Canadian Cancer Society Research Institute.