Search

Your search keyword '"Commins, Scott P."' showing total 509 results
Start Over Author "Commins, Scott P."
509 results on '"Commins, Scott P."'

5. Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Author

Chehade, Mirna, Wright, Benjamin L., Atkins, Dan, Aceves, Seema S., Ackerman, Steven J., Assa’ad, Amal H., Bauer, Maureen, Collins, Margaret H., Commins, Scott P., Davis, Carla M., Dellon, Evan S., Doerfler, Bethan, Gleich, Gerald J., Gupta, Sandeep K., Hill, David A., Jensen, Elizabeth T., Katzka, David, Kliewer, Kara, Kodroff, Ellyn, Kottyan, Leah C., Kyle, Shay, Muir, Amanda B., Pesek, Robert D., Peterson, Kathryn, Shreffler, Wayne G., Spergel, Jonathan M., Strobel, Mary Jo, Wechsler, Joshua, Zimmermann, Nives, Furuta, Glenn T., and Rothenberg, Marc E.

Published
2023
Full Text
View/download PDF

14. Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome.

Author

Wilson, Jeffrey M., Erickson, Loren, Levin, Michael, Ailsworth, Samuel M., Commins, Scott P., and Platts‐Mills, Thomas A. E.

Subjects
ANAPHYLAXIS, IMMUNOGLOBULIN E, FOOD allergy, LYME disease, URTICARIA, TICKS, SYNDROMES
Abstract

The recent recognition of a syndrome of tick‐acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibodies against the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non‐primate mammals. Thus, fittingly, this allergic disorder is now called the alpha‐gal syndrome (AGS). The syndrome is strikingly regional, reflecting the important role of tick bites in sensitization, and is more common in demographic groups at risk of tick exposure. Reactions in AGS are delayed, often by 2–6 h after ingestion of mammalian meat. In addition to classic allergic symptomatology such as urticaria and anaphylaxis, AGS is increasingly recognized as a cause of isolated gastrointestinal morbidity and alpha‐gal sensitization has also been linked with cardiovascular disease. The unusual link with tick bites may be explained by the fact that allergic cells and mediators are mobilized to the site of tick bites and play a role in resistance against ticks and tick‐borne infections. IgE directed to alpha‐gal is likely an incidental consequence of what is otherwise an adaptive immune strategy for host defense against endo‐ and ectoparasites, including ticks. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

42. Alpha-Gal Sensitization in a US Screening Population Is Not Associated With a Decreased Meat Intake or Gastrointestinal Symptoms.

Author

McGill, Sarah K., Commins, Scott P., Peery, Anne F., Galanko, Joseph, Keku, Temitope O., Shaheen, Nicholas J., Anderson, Chelsea, and Sandler, Robert S.

Subjects
*IMMUNOGLOBULIN E, *SYMPTOMS, *MEAT, *SEROCONVERSION, *FOOD consumption
Abstract

INTRODUCTION: Patients with alpha-gal syndrome, a delayed reaction to mammalian meat, can present with isolated gastrointestinal (GI) symptoms. We aimed to estimate the frequency of alpha-gal sensitization in a Southeastern US population and determine the association between sensitization and mammalian product dietary intake or GI symptoms. METHODS: We performed a cross-sectional study of participants who underwent a screening colonoscopy at our center between 2013 and 2015. We quantified serum alpha-gal immunoglobulin E antibodies in participants who were prospectively enrolled at screening colonoscopy and compared diet intake and lower GI symptoms reported in standardized questionnaires among those with elevated versus no alphagal IgE antibodies. RESULTS: Alpha-gal IgE antibodies were common--31.4% of screening colonoscopy participants (127 of 404) had elevated serum alpha-gal IgE >0.1 kU/L. Alpha-gal--sensitized participants endorsed similar rates of abdominal pain compared with those without alpha-gal antibodies (33% vs 38%, adjusted odds ratio 0.9, 95% confidence interval 0.7-1.3). Mammalian meat consumption did not differ based on alphagal sensitization status (average 1.43 servings/d in sensitized subjects vs 1.50 in alpha-gal IgE--negative subjects, P = 0.9). Alpha-gal--sensitized participants with levels ≥10 (n = 21) were overrepresented in the lowest quartiles of mammalian meat consumption, but not among those with GI symptoms in general. Participants with high alpha-gal antibody levels >2 kU/L (n = 45) or ≥10 U/L (n = 21) did not have a reduced mean daily mammalian meat intake compared with seronegative people. DISCUSSION: Elevated alpha-gal IgE antibodies were common and not associated with a reduced mammalian meat intake, abdominal pain, or diarrhea. Seropositivity did not predict symptomatic alpha-gal sensitization in this general screening population. Other host factors likely contribute to the phenotypic expression of alpha-gal syndrome. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

48. Clinical and laboratory features of patients diagnosed with alpha‐gal syndrome—2010–2019.

Author

Binder, Alison M., Cherry‐Brown, Dena, Biggerstaff, Brad J., Jones, Emma S., Amelio, Claire L., Beard, Charles B., Petersen, Lyle R., Kersh, Gilbert J., Commins, Scott P., and Armstrong, Paige A.

Subjects
PATHOLOGICAL laboratories, SYMPTOMS, FOOD allergy, RACE, AGE of onset, TICK infestations, MILK allergy
Abstract

Background: Alpha‐gal syndrome (AGS) is an IgE‐mediated allergy to galactose‐alpha‐1,3‐galactose. Clinical presentation ranges from hives to anaphylaxis; episodes typically occur 2–6 h after exposure to alpha‐gal‐containing products. In the United States, lone star tick bites are associated with the development of AGS. To characterize features of AGS, we evaluated a cohort of patients presenting for care at the University of North Carolina, focusing on symptoms, severity, and identifying features unique to specific alpha‐gal‐containing product exposures. Methods: We performed a chart review and descriptive analysis of 100 randomly selected patients with AGS during 2010–2019. Results: Median age at onset was 53 years, 56% were female, 95% reported White race, 86% reported a history of tick bite, and 75% met the criteria for anaphylaxis based on the involvement of ≥2 organ systems. Those reporting dairy reactions were significantly less likely to report isolated mucocutaneous symptoms (3% vs. 24%; ratio [95% CI]: 0.1 [0.1, 0.3]) than those who tolerated dairy, and were more likely to report gastrointestinal symptoms (79% vs. 59%; ratio [95% CI]: 1.3 [0.7, 2.6]), although this difference was not statistically significant. Dairy‐tolerant patients demonstrated higher alpha‐gal sIgE titers (as a percentage of total IgE) than dairy‐reactive patients (GM 4.1 [95% CI: 2.7, 6.1] vs. GM 2.5 [95% CI: 1.3, 4.8], respectively; ratio −1.6 [95% CI: −1.0, 3.9]). Conclusion: While tick exposure is common in the southern United States, nearly all AGS patients reported a tick bite. Gastrointestinal symptoms were prominent among those reporting reactions to dairy. Anaphylaxis was common, underscoring the severity and need to raise awareness of AGS among patients and providers. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results