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137 results on '"Commisso, Mauro"'

3. A Novel Strategy for Glioblastoma Treatment by Natural Bioactive Molecules Showed a Highly Effective Anti-Cancer Potential.

Author

Giammona, Alessandro, Commisso, Mauro, Bonanomi, Marcella, Remedia, Sofia, Avesani, Linda, Porro, Danilo, Gaglio, Daniela, Bertoli, Gloria, and Lo Dico, Alessia

Abstract

Glioblastoma (GBM) is a severe form of brain tumor that has a high fatality rate. It grows aggressively and most of the time results in resistance to traditional treatments like chemo- and radiotherapy and surgery. Biodiversity, beyond representing a big resource for human well-being, provides several natural compounds that have shown great potential as anticancer drugs. Many of them are being extensively researched and significantly slow GBM progression by reducing the proliferation rate, migration, and inflammation and also by modulating oxidative stress. Here, the use of some natural compounds, such as Allium lusitanicum, Succisa pratensis, and Dianthus superbus, was explored to tackle GBM; they showed their impact on cell number reduction, which was partially given by cell cycle quiescence. Furthermore, a reduced cell migration ability was reported, accomplished by morphological cytoskeleton changes, which even highlighted a mesenchymal–epithelial transition. Furthermore, metabolic studies showed an induced cell oxidative stress modulation and a massive metabolic rearrangement. Therefore, a new therapeutic option was suggested to overcome the limitations of conventional treatments and thereby improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Role of the metallo-reductase FADING and vacuolinos in anthocyanin degradation in flowers and fruits

Author

Passeri, Valentina, primary, Li, Shuangjiang, additional, Strazzer, Pamela, additional, i Calvó’, Enric Martínez, additional, Senden, Esther, additional, Guzzo, Flavia, additional, Commisso, Mauro, additional, Spelt, Cornelis, additional, Vandenbussche, Michiel, additional, Bliek, Mattijs, additional, Verweij, Walter, additional, Koes, Ronald, additional, and Quattrocchio, Francesca M., additional

Published
2023
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23. Ethylene-auxin crosstalk regulates postharvest fruit ripening process in apple

Author

Busatto, Nicola, primary, Tadiello, Alice, additional, Moretto, Marco, additional, Farneti, Brian, additional, Populin, Francesca, additional, Vrhovsek, Urska, additional, Commisso, Mauro, additional, Sartori, Elisa, additional, Sonego, Paolo, additional, Biasioli, Franco, additional, Costa, Guglielmo, additional, Guzzo, Flavia, additional, Fontana, Paolo, additional, Engelen, Kristof, additional, and Costa, Fabrizio, additional

Published
2021
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24. Red Carrot Cells Cultured in vitro Are Effective, Stable, and Safe Ingredients for Skin Care, Nutraceutical, and Food Applications

Author

Bianconi, Martino, primary, Ceriotti, Laura, additional, Cuzzocrea, Salvatore, additional, Esposito, Emanuela, additional, Pressi, Giovanna, additional, Sgaravatti, Elena, additional, Bertaiola, Oriana, additional, Guarnerio, Chiara, additional, Barbieri, Elisa, additional, Semenzato, Alessandra, additional, Negri, Stefano, additional, Commisso, Mauro, additional, Avesani, Linda, additional, and Guzzo, Flavia, additional

Published
2020
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25. Nodulating white lupins take advantage of the reciprocal interplay between N and P nutritional responses.

Author

Buoso, Sara, Zamboni, Anita, Franco, Alessandro, Commisso, Mauro, Guzzo, Flavia, Varanini, Zeno, Pinton, Roberto, Tomasi, Nicola, and Zanin, Laura

Subjects
LUPINES, DEFICIENCY diseases, AGRICULTURAL productivity, PHENOLS, NUTRITIONAL status, LEGUMES, PHOSPHORUS in water, NITROGEN
Abstract

The low bioavailability of nutrients, especially nitrogen (N) and phosphorus (P), is one of the most limiting factors for crop production. In this study, under N- and P-free nutrient solution (-N-P), nodulating white lupin plants developed some nodules and analogous cluster root structures characterized by different morphological, physiological, and molecular responses than those observed upon single nutrient deficiency (strong acidification of external media, a better nutritional status than -N+P and +N-P plants). The multi-elemental analysis highlighted that the concentrations of nutrients in white lupin plants were mainly affected by P availability. Gene-expression analyses provided evidence of interconnections between N and P nutritional pathways that are active to promote N and P balance in plants. The root exudome was mainly characterized by N availability in nutrient solution, and, in particular, the absence of N and P in the nutrient solution triggered a high release of phenolic compounds, nucleosides monophosphate and saponines by roots. These morphological, physiological, and molecular responses result from a close interplay between N and P nutritional pathways. They contribute to the good development of nodulating white lupin plants when grown on N- and P-free media. This study provides evidence that limited N and P availability in the nutrient solution can promote white lupin-Bradyrhizobium symbiosis, which is favourable for the sustainability of legume production. [ABSTRACT FROM AUTHOR]

Published
2022
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29. The Arabidopsis thaliana Knockout Mutant for Phytochelatin Synthase1 (cad1-3) Is Defective in Callose Deposition, Bacterial Pathogen Defense and Auxin Content, But Shows an Increased Stem Lignification

Author

De Benedictis, Maria, primary, Brunetti, Cecilia, additional, Brauer, Elizabeth K., additional, Andreucci, Andrea, additional, Popescu, Sorina C., additional, Commisso, Mauro, additional, Guzzo, Flavia, additional, Sofo, Adriano, additional, Ruffini Castiglione, Monica, additional, Vatamaniuk, Olena K., additional, and Sanità di Toppi, Luigi, additional

Published
2018
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30. Apple fruit superficial scald resistance mediated by ethylene inhibition is associated with diverse metabolic processes

Author

Busatto, Nicola, primary, Farneti, Brian, additional, Commisso, Mauro, additional, Bianconi, Martino, additional, Iadarola, Barbara, additional, Zago, Elisa, additional, Ruperti, Benedetto, additional, Spinelli, Francesco, additional, Zanella, Angelo, additional, Velasco, Riccardo, additional, Ferrarini, Alberto, additional, Chitarrini, Giulia, additional, Vrhovsek, Urska, additional, Delledonne, Massimo, additional, Guzzo, Flavia, additional, Costa, Guglielmo, additional, and Costa, Fabrizio, additional

Published
2017
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31. Determination of total phenolic compounds in recioto red wine and commercially available cocoa pills by HPLC-DAD/ESI-MS

Author

Ahmed, Sajeela, Commisso, Mauro, Negri, Stefano, Gebrie, Mebratu Alebachew, Ahmed, Naseer, Rungatscher, Alessio, Luciani, Giovanni Battista, Guzzo, Flavia, and Faggian, Giuseppe

Abstract

Objective: Flavonoids are antioxidants present in grapes, tea, fruits, vegetables, cocoa and wines. Pervious studies shows that red wine and cocoa can help to reduce cardiovascular diseases and cancer (1,2).The purpose of this study is to compare the total amount of flavonoids in receito red wine and commercially available pills of cocoa. Methodology: Methanolic extracts of total phenolic compounds from four years old recioto red wine (Masi Agricola) and cocoa pills powder (Mars) were analysed by using both HPLC-DAD and HPLC ESI-MS(3). Results: Twenty-three different phenolic compounds were detected and identified in recioto, while in cocoa eighteen different phenolic compounds, mainly derived from catechin and epicatechin, were found. In quantitative analysis (HPLC-DAD) of cocoa, 250 ±1mg of flavanols were found in 12500mg of one pill; however, 90±1mg of flavanols detected in1litre of recioto wine. Conclusion: The amount of flavonoids found in commercially available pills of cocoa were almost three times more than those were found in recioto red wine., Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 4 (2016)

Published
2016
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32. Phenolic compounds in recioto red wine vs. commercially available cocoa pills using HPLC-DAD/ESI-MS

Author

Ahmed, Sajeela, Commisso, Mauro, Negri, Stefano, Gebrie, Mebratu Alebachew, Ahmed, Naseer, Rungatscher, Alessio, Luciani, Giovanni Battista, Guzzo, Flavia, and Faggian, Giuseppe

Abstract

Objective: Flavonoids are antioxidants present in grapes, tea, fruits, vegetables, cocoa and wines. Previous studies shows that red wine and cocoa can help to prevent cardiovascular diseases and cancer (1,2).The aim of this study is to compare the total amount of Flavonoids in receito red wine and commercially available pills of cocoa. Methodology: Methanolic extracts of total phenolic compounds from four years old recioto red wine (Masi Agricola) and cocoa pills powder (Mars) were analysed by using both HPLC-DAD and HPLC ESI-MS(3). Results:Twenty-three different phenolic compounds were detected and identified in recioto, while in cocoa eighteen different phenolic compounds, mainly derived from catechin and epicatechin, were found. In quantitative analysis (HPLC-DAD) of cocoa, 250±1mg of flavanols were found in 12500mg of one pill; however, 90±1mg of flavanols detected in1litre of recioto red wine. Conclusion: The amount of flavonoids found in commercially available pills of cocoa were three times more than those found in recioto red wine., Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 3 (2016)

Published
2016
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33. Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.)

Author

Commisso, Mauro, primary, Bianconi, Martino, additional, Di Carlo, Flavia, additional, Poletti, Stefania, additional, Bulgarini, Alessandra, additional, Munari, Francesca, additional, Negri, Stefano, additional, Stocchero, Matteo, additional, Ceoldo, Stefania, additional, Avesani, Linda, additional, Assfalg, Michael, additional, Zoccatelli, Gianni, additional, and Guzzo, Flavia, additional

Published
2017
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35. The Induction of Noble Rot (Botrytis cinerea) Infection during Postharvest Withering Changes the Metabolome of Grapevine Berries (Vitis vinifera L., cv. Garganega)

Author

Negri, Stefano, primary, Lovato, Arianna, additional, Boscaini, Filippo, additional, Salvetti, Elisa, additional, Torriani, Sandra, additional, Commisso, Mauro, additional, Danzi, Roberta, additional, Ugliano, Maurizio, additional, Polverari, Annalisa, additional, Tornielli, Giovanni B., additional, and Guzzo, Flavia, additional

Published
2017
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36. A group of grapevine MYBA transcription factors located in chromosome 14 control anthocyanin synthesis in vegetative organs with different specificities compared with the berry color locus

Author

Matus, José Tomás, primary, Cavallini, Erika, additional, Loyola, Rodrigo, additional, Höll, Janine, additional, Finezzo, Laura, additional, Dal Santo, Silvia, additional, Vialet, Sandrine, additional, Commisso, Mauro, additional, Roman, Federica, additional, Schubert, Andrea, additional, Alcalde, José Antonio, additional, Bogs, Jochen, additional, Ageorges, Agnès, additional, Tornielli, Giovanni Battista, additional, and Arce‐Johnson, Patricio, additional

Published
2017
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39. Untargeted metabolomics to study scion x rootstock x nitrogen interactions on berry content

Author

HABRAN, Aude, HELWI, Pierre, HILBERT, Ghislaine, GOMES, Eric, VAN LEEUWEN, Kees, NEGRI, Stefano, COMMISSO, Mauro, GUZZO, Flavia, DELROT, Serge, Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), and Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)

Subjects
stomatognathic diseases, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, ComputingMilieux_MISCELLANEOUS
Abstract

oral presentation+proceedings

Published
2015

40. Additional file 15. of Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome

Author

Anesi, Andrea, Stocchero, Matteo, Santo, Silvia Dal, Commisso, Mauro, Zenoni, Sara, Ceoldo, Stefania, Tornielli, Giovanni, Siebert, Tracey, Herderich, Markus, Pezzotti, Mario, and Guzzo, Flavia

Abstract

Loading plots of several O2PLS-DA models investigating the relationships between environmental and vineyard features and metabolites detected by HPLC-ESI-MS and GC-MS. Each feature and the relative statistical classes are indicated in the plot. Groups of metabolites are shown in different colors according to the legends. (PDF 394 kb)

Published
2015
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41. Additional file 4: of Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome

Author

Anesi, Andrea, Stocchero, Matteo, Santo, Silvia Dal, Commisso, Mauro, Zenoni, Sara, Ceoldo, Stefania, Tornielli, Giovanni, Siebert, Tracey, Herderich, Markus, Pezzotti, Mario, and Guzzo, Flavia

Abstract

Method used to build the orthogonal constrained PLS-DA model and the mathematical properties of the approach used to post-transform the oCPLS2-DA model. (DOCX 134 kb)

Published
2015
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42. Additional file 2: Table S2. of Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome

Author

Anesi, Andrea, Stocchero, Matteo, Santo, Silvia Dal, Commisso, Mauro, Zenoni, Sara, Ceoldo, Stefania, Tornielli, Giovanni, Siebert, Tracey, Herderich, Markus, Pezzotti, Mario, and Guzzo, Flavia

Abstract

Main climatic parameters recorded for the 2006, 2007 and 2008 vintages by meteorological stations located in each macrozone (Lake Garda, Valpolicella and Soave) and kindly provided by A.R.P.A.V. (Azienda Regionale per la Prevenzione Ambientale del Veneto, Centro Metereologico di Teolo, Padova, Italy). The values reported for each parameter relate to: a) the period 1 April to 30 September and 2) ripening phenological stage (42 days before harvesting). The Huglin index is defined as the sum of average and maximum temperatures above 10 °C in the period 1 April to 30 September for a given location; K = 1.04. (DOCX 16 kb)

Published
2015
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43. Additional file 1: Table S1. of Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome

Author

Anesi, Andrea, Stocchero, Matteo, Santo, Silvia Dal, Commisso, Mauro, Zenoni, Sara, Ceoldo, Stefania, Tornielli, Giovanni, Siebert, Tracey, Herderich, Markus, Pezzotti, Mario, and Guzzo, Flavia

Abstract

Principal features of each vineyard: a) macrozone; b) height above sea level; c) rootstock type; d) row direction (N–S = north–south; E–W = east–west; e) training system; f) soil type, based on USDA classification triangle ( www.nrcs.usda.gov/Internet/FSE_DOCUMENTS/16/stelprdb1044821.ppt ); g) total lime content, percentage; h) active lime content, percentage; i) pH; j) organic substance content, percentage; k) exchangeable phosphorus content (mg/kg). Soil composition data were provided by ORVIT – Società per la Valorizzazione dei Vini Veronesi (Verona, Italy). (DOCX 20 kb)

Published
2015
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44. A metabolomic approach of scion x rootstock x nitrogen interactions on berry content

Author

Habran, Aude, Helwi, Pierre, Hilbert, Ghislaine, GOMES, Eric, Van Leeuwen, Kees, NEGRI, Stefano, Commisso, Mauro, Guzzo, Flavia, Delrot, Serge, Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), and Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)

Subjects
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

45. IMPACT OF PHENYLPROPANOIDS ON HEAT STRESS PROTECTION

Author

Commisso, Mauro

Subjects
coumaroyl quinic acid, Arabidopsis thaliana, chemical approach, secondary metabolites, biological role, in vitro cell cultures, anthocyanins, Daucus carota, heat stress, Settore BIO/01 - Botanica Generale, molecular precursors, whole plants, phenylpropanoids, feeding
Published
2014

48. Apple fruit superficial scald resistance mediated by ethylene inhibition is associated with diverse metabolic processes.

Author

Busatto, Nicola, Farneti, Brian, Commisso, Mauro, Bianconi, Martino, Iadarola, Barbara, Zago, Elisa, Ruperti, Benedetto, Spinelli, Francesco, Zanella, Angelo, Velasco, Riccardo, Ferrarini, Alberto, Chitarrini, Giulia, Vrhovsek, Urska, Delledonne, Massimo, Guzzo, Flavia, Costa, Guglielmo, and Costa, Fabrizio

Subjects
APPLE fruit-borer, APPLE scald, ETHYLENE, DISCOLORATION, PLANT physiology, PLANT development
Abstract

Fruits stored at low temperature can exhibit different types of chilling injury. In apple, one of the most serious physiological disorders is superficial scald, which is characterized by discoloration and brown necrotic patches on the fruit exocarp. Although this phenomenon is widely ascribed to the oxidation of α-farnesene, its physiology is not yet fully understood. To elucidate the mechanism of superficial scald development and possible means of prevention, we performed an integrated metabolite screen, including an analysis of volatiles, phenols and lipids, together with a large-scale transcriptome study. We also determined that prevention of superficial scald, through the use of an ethylene action inhibitor, is associated with the triggering of cold acclimation-related processes. Specifically, the inhibition of ethylene perception stimulated the production of antioxidant compounds to scavenge reactive oxygen species, the synthesis of fatty acids to stabilize plastid and vacuole membranes against cold temperature, and the accumulation of the sorbitol, which can act as a cryoprotectant. The pattern of sorbitol accumulation was consistent with the expression profile of a sorbitol 6-phosphate dehydrogenase, MdS6 PDH, the overexpression of which in transgenic Arabidopsis thaliana plants confirmed its involvement in the cold acclimation and freezing tolerance. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Performance comparison of electrospray ionization and atmospheric pressure chemical ionization in untargeted and targeted liquid chromatography/mass spectrometry based metabolomics analysis of grapeberry metabolites.

Author

Commisso, Mauro, Anesi, Andrea, Dal Santo, Silvia, and Guzzo, Flavia

Subjects
*METABOLOMICS, *ELECTROSPRAY ionization mass spectrometry, *LIQUID chromatography-mass spectrometry, *METABOLITES, *ANTHOCYANINS
Abstract

RATIONALE: Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are both used to generate ions for the analysis of metabolites by liquid chromatography/mass spectrometry (LC/MS). We compared the performance of these methods for the analysis of Corvina grapevine berry methanolic extracts, which are complex mixtures of diverse metabolites. METHODS: Corvina berries representing three ripening stages (veraison, early-ripening and full-ripening) were collected during two growing seasons, powdered and extracted with methanol. Untargeted metabolomic analysis was carried out by LC/ESI-MS and LC/APCI-MS. Processed data files were assembled into a data matrix for multivariate statistical analysis. The limits of detection (LODs), limits of quantification (LOQs), linear ranges, and matrix effects were investigated for strongly polar metabolites such as sucrose and tartaric acid and for moderately polar metabolites such as caftaric acid, epicatechin and quercetin 3-O-glucoside. RESULTS: Multivariate statistical analysis of the 608 features revealed that APCI was particularly suitable for the ionization of strongly polar metabolites such as sugars and organic acids, whereas ESI was more suitable for moderately polar metabolites such as flavanols, flavones and both glycosylated and acylated anthocyanins. APCI generated more fragment ions whereas ESI generated more adducts. ESI achieved lower LODs and LOQs for sucrose and tartaric acid but featured narrower linear ranges and greater matrix effects. CONCLUSIONS: ESI and APCI are not complementary ion sources. Indeed, ESI can be exploited to analyze moderately polar metabolites, whereas APCI can be used to investigate weakly polar/non-polar metabolites and, as demonstrated by our results, also strongly polar metabolites. ESI and APCI can be used in parallel, exploiting their strengths to cover the plant metabolome more broadly than either method alone. [ABSTRACT FROM AUTHOR]

Published
2017
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