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38 results on '"Cong, Guang‐Ting"'

17. Evaluating the Role of Subacromial Impingement in Rotator Cuff Tendinopathy: Development and Analysis of a Novel Murine Model

Author

Cong, Guang-Ting, Lebaschi, Amir H., Camp, Christopher L., Carballo, Camila B., Nakagawa, Yusuke, Wada, Susumu, Deng, Xiang-Hua, and Rodeo, Scott A.

Subjects
Male, Mice, Inbred C57BL, Disease Models, Animal, Rotator Cuff, Shoulder Impingement Syndrome, Animals, Gene Expression, musculoskeletal system, Article, Rotator Cuff Injuries
Abstract

Subacromial impingement of the rotator cuff is understood as a contributing factor in the development of rotator cuff tendinopathy. However, changes that occur in the impinged tendon are poorly understood and warrant further study. To enable further study of rotator cuff tendinopathy, we performed a controlled laboratory study to determine feasibility and baseline characteristics of a new murine model for subacromial impingement. This model involves surgically inserting a microvascular clip into the subacromial space in adult C57Bl/6 mice. Along with a sham surgery arm, 90 study animals were distributed among time point groups for sacrifice up to 6 weeks. All animals underwent bilateral surgery (total N = 180). Biomechanical, histologic, and molecular analyses were performed to identify and quantify the progression of changes in the supraspinatus tendon. Decreases in failure force and stiffness were found in impinged tendon specimens compared to sham and no-surgery controls at all study time points. Semi-quantitative scoring of histologic specimens demonstrated significant, persistent tendinopathic changes over 6 weeks. Quantitative real-time polymerase chain reaction analysis of impinged tendon specimens demonstrated persistently increased expression of genes related to matrix remodeling, inflammation, and tendon development. Overall, this novel murine subacromial impingement model creates changes consistent with acute tendonitis, which may mimic the early stages of rotator cuff tendinopathy. A robust, simple, and reproducible animal model of rotator cuff tendinopathy is a valuable research tool to allow further studies of cellular and molecular mechanisms and evaluation of therapeutic interventions in rotator cuff tendinopathy. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2780-2788, 2018.

Published
2018

20. Postoperative Tendon Loading With Treadmill Running Delays Tendon‐to‐Bone Healing: Immunohistochemical Evaluation in a Murine Rotator Cuff Repair Model

Author

Wada, Susumu, primary, Lebaschi, Amir H., additional, Nakagawa, Yusuke, additional, Carballo, Camila B., additional, Uppstrom, Tyler J., additional, Cong, Guang‐Ting, additional, Album, Zoe M., additional, Hall, Arielle J., additional, Ying, Liang, additional, Deng, Xiang‐Hua, additional, and Rodeo, Scott A., additional

Published
2019
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27. Treatment of Osteochondral Lesions of the Talus: An Evidence-based Opinionated Review

Author

Cong, Guang-Ting, Chinnakkannu, Karthikeyan, Krishnamoorthy, Vignesh P., Di Lenarda, Luca, Mikhail, Christopher M., and Vulcano, Ettore

Abstract

Osteochondral lesions of the talus (OLTs) are a much-discussed topic in foot and ankle surgery due to their refractive nature to therapy. OLTs include fractures of the talar osteochondral surface from acute trauma or chronic repetitive injury, and their chronic subset in young patients conventionally referred to as osteochondritis dessicans. OLTs do not tend to heal well, and their treatments remain only moderately successful without an obvious superior method. The purpose of this review is to summarize the treatment of OLTs using current available literature and provide an opinionated preferred treatment algorithm.Level of Evidence:Diagnostic Level V. See Instructions for Authors for a complete description of levels of evidence.

Published
2024
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28. Animal models for rotator cuff repair

Author

Lebaschi, Amir, primary, Deng, Xiang-Hua, additional, Zong, Jianchun, additional, Cong, Guang-Ting, additional, Carballo, Camila B., additional, Album, Zoe M., additional, Camp, Christopher, additional, and Rodeo, Scott A., additional

Published
2016
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31. The Walking Speed Questionnaire

Author

Cong, Guang-Ting, primary, Cohn, Matthew R., additional, Villa, Jordan C., additional, Kerwin, Lewis J., additional, Rosen, Natalie, additional, Fang, Xiu Zhen, additional, Christos, Paul J., additional, Evrony, Ayelet, additional, Chen, Jin, additional, Torres, Ashley, additional, and Lane, Joseph M., additional

Published
2016
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36. Factors Associated With Early Functional Outcome After Hip Fracture Surgery

Author

Cohn, Matthew R., Cong, Guang-Ting, Nwachukwu, Benedict U., Patt, Minda L., Desai, Pingal, Zambrana, Lester, and Lane, Joseph M.

Abstract

Background: Hip fractures are common in the elderly and are likely to become more prevalent as the US population ages. Early functional status is an indicator of longer term outcome, yet in-hospital predictors of functional recovery, particularly time of surgery and composition of support staff, after hip fracture surgery have not been well studied.Methods: Ninety-nine consecutive patients underwent hip fracture surgery by a single surgeon between 2009 and 2013. Surgery after 48 hours was deemed as surgical delay, and surgery after 5 pmwas deemed as after hours. Surgical support staff experience was determined by experts from our institution as well as documented level of training. Functional status was determined by independent ambulation on postoperative day (POD) 3.Results: On POD3, 48 (79%) of 62 patients with no delay were able to ambulate, whereas only 14 (38%) of 37 patients with delayed surgery were able to ambulate (P< .001). This relationship persisted when adjusted for American Society of Anesthesiologist classification. No delay in patients older than 80 (odds ratio [OR], 6.91; 95% confidence interval [CI], 2.16-22.10) and females (OR, 7.05; 95% CI, 2.34-21.20) was associated with greater chance of early ambulation. After-hours surgery was not associated with ambulation (P= .35). Anesthesiologist and circulating nurse experience had no impact on patient’s ambulatory status; however, nonorthopedic scrub technicians were associated with worse functional status (OR 7.50; 95% CI, 1.46-38.44, P= .01).Conclusion: Surgical delay and nonorthopedic scrub technicians are associated with worse early functional outcome after hip fracture surgery. Surgical delay should be avoided in older patients and women. More work should be done to understand the impact of surgical team composition on outcome.

Published
2016
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38. Risk Factors for 30- and 90-Day Readmission due to Intestinal Bowel Obstruction after Posterior Lumbar Fusion.

Author

Mikhail CM, Warburton A, Girdler SJ, Platt S, Cong GT, and Cho SK

Abstract

Study Design: A retrospective analysis of data from the Healthcare Cost and Utilization Project Nationwide Readmissions Database (HCUP-NRD)., Purpose: To identify the perioperative characteristics associated with 30-day and 90-day readmission due to intestinal bowel obstructions (IBOs) following posterior lumbar fusion (PLF) procedure., Overview of Literature: PLF procedures are used to repair spinal injuries and curvature deformities. IBO is a common surgical complication and its repair often necessitates surgery that increases the readmission rates and healthcare costs. Previous studies have identified the preoperative risk factors for 30-day readmissions in PLF; however, no study has specifically investigated IBO or identified risk factors for 90-day readmissions., Methods: Data on demographic characteristics and medical comorbidities of patients who underwent PLF with subsequent readmission were obtained from the HCUP-NRD. The perioperative characteristics that were significantly different between patients readmitted with and without an active diagnosis of IBO were identified with bivariate analysis for both 30-day and 90-day readmissions. The significant characteristics were then included in a multivariate analysis to identify those that were independently associated with 30- day and 90-day readmissions., Results: Drug abuse (odds ratio [OR], 4.00), uncomplicated diabetes (OR, 2.06), having Medicare insurance (OR, 1.65), age 55-64 years (OR, 2.42), age 65-79 years (OR, 2.77), and age >80 years (OR, 3.87) were significant risk factors for 30-day readmission attributable to IBO after a PLF procedure., Conclusions: Of the several preoperative risk factors identified for readmission with IBO after PLF surgery, drug abuse had the strongest association and was likely to be the most clinically relevant factor. Physicians and care teams should understand the risks of opioid-based pain management regimens, attempt to manage pain with a multimodal approach, and minimize the opioid use.

Published
2021
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