Search

Your search keyword '"Cong, Yusheng"' showing total 28 results
Start Over Author "Cong, Yusheng"
28 results on '"Cong, Yusheng"'

2. KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

Author

Ran, Jie, primary, Guo, Guizhi, additional, Zhang, Sai, additional, Zhang, Yufei, additional, Zhang, Liang, additional, Li, Dengwen, additional, Wu, Shian, additional, Cong, Yusheng, additional, Wang, Xiaohong, additional, Xie, Songbo, additional, Zhao, Huijie, additional, Liu, Hongbin, additional, Ou, Guangshuo, additional, Zhu, Xueliang, additional, Zhou, Jun, additional, and Liu, Min, additional

Published
2024
Full Text
View/download PDF

5. PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Author

Lu, Hezhe, Liu, Shujing, Zhang, Gao, Wu, Bin, Zhu, Yueyao, Frederick, Dennie T., Hu, Yi, Zhong, Wenqun, Randell, Sergio, Sadek, Norah, Zhang, Wei, Chen, Gang, Cheng, Chaoran, Zeng, Jingwen, Wu, Lawrence W., Zhang, Jie, Liu, Xiaoming, Xu, Wei, Krepler, Clemens, Sproesser, Katrin, Xiao, Min, Miao, Benchun, Liu, Jianglan, Song, Claire D., Liu, Jephrey Y., Karakousis, Giorgos C., Schuchter, Lynn M., Lu, Yiling, Mills, Gordon, Cong, Yusheng, Chernoff, Jonathan, Guo, Jun, Boland, Genevieve M., Sullivan, Ryan J., Wei, Zhi, Field, Jeffrey, Amaravadi, Ravi K., Flaherty, Keith T., Herlyn, Meenhard, Xu, Xiaowei, and Guo, Wei

Published
2017
Full Text
View/download PDF

6. Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Author

Lu, Hezhe, Liu, Shujing, Zhang, Gao, Wu, Bin, Zhu, Yueyao, Frederick, Dennie T., Hu, Yi, Zhong, Wenqun, Randell, Sergio, Sadek, Norah, Zhang, Wei, Chen, Gang, Cheng, Chaoran, Zeng, Jingwen, Wu, Lawrence W., Zhang, Jie, Liu, Xiaoming, Xu, Wei, Krepler, Clemens, Sproesser, Katrin, Xiao, Min, Miao, Benchun, Liu, Jianglan, Song, Claire D., Liu, Jephrey Y., Karakousis, Giorgos C., Schuchter, Lynn M., Lu, Yiling, Mills, Gordon, Cong, Yusheng, Chernoff, Jonathan, Guo, Jun, Boland, Genevieve M., Sullivan, Ryan J., Wei, Zhi, Field, Jeffrey, Amaravadi, Ravi K., Flaherty, Keith T., Herlyn, Meenhard, Xu, Xiaowei, and Guo, Wei

Published
2019
Full Text
View/download PDF

12. Neuroprotective effects of salidroside on ageing hippocampal neurons and naturally ageing mice via the PI3K/Akt/TERT pathway.

Author

Zhu, Lin, Liu, Zhenchao, Ren, Yuqian, Wu, Xiaolin, Liu, Yingjuan, Wang, Tingting, Li, Yizhao, Cong, Yusheng, and Guo, Yunliang

Subjects
NEURONS, PHENOLS, HIPPOCAMPUS (Brain), ANIMAL experimentation, PHOSPHOTRANSFERASES, GLYCOSIDES, RATS, TRANSFERASES, NEUROPROTECTIVE agents, AGING, RESEARCH funding, MICE, PHARMACODYNAMICS
Abstract

Studies have found that salidroside, isolated from Rhodiola rosea L, has various pharmacological activities, but there have been no studies on the effects of salidroside on brain hippocampal senescence. The purpose of this study was to investigate the mechanistic role of salidroside in hippocampal neuron senescence and injury. In this study, long-term cultured primary rat hippocampal neurons and naturally aged C57 mice were treated with salidroside. The results showed that salidroside increased the viability and MAP2 expression, reduced β-galactosidase (β-gal) levels of rat primary hippocampal neurons. Salidroside also improved cognition dysfunction in ageing mice and alleviated neuronal degeneration in the ageing mice CA1 region. Moreover, salidroside decreased the levels of oxidative stress and p21, p16 protein expressions of hippocampal neurons and ageing mice. Salidroside promoted telomerase reverse transcriptase (TERT) protein expression via the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway. In conclusion, our findings suggest that salidroside has the potential to be used as a therapeutic strategy for anti-ageing and ageing-related disease treatment. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

13. Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Author

Lu, Hezhe, primary, Liu, Shujing, additional, Zhang, Gao, additional, Wu, Bin, additional, Zhu, Yueyao, additional, Frederick, Dennie T., additional, Hu, Yi, additional, Zhong, Wenqun, additional, Randell, Sergio, additional, Sadek, Norah, additional, Zhang, Wei, additional, Chen, Gang, additional, Cheng, Chaoran, additional, Zeng, Jingwen, additional, Wu, Lawrence W., additional, Zhang, Jie, additional, Liu, Xiaoming, additional, Xu, Wei, additional, Krepler, Clemens, additional, Sproesser, Katrin, additional, Xiao, Min, additional, Miao, Benchun, additional, Liu, Jianglan, additional, Song, Claire D., additional, Liu, Jephrey Y., additional, Karakousis, Giorgos C., additional, Schuchter, Lynn M., additional, Lu, Yiling, additional, Mills, Gordon, additional, Cong, Yusheng, additional, Chernoff, Jonathan, additional, Guo, Jun, additional, Boland, Genevieve M., additional, Sullivan, Ryan J., additional, Wei, Zhi, additional, Field, Jeffrey, additional, Amaravadi, Ravi K., additional, Flaherty, Keith T., additional, Herlyn, Meenhard, additional, Xu, Xiaowei, additional, and Guo, Wei, additional

Published
2018
Full Text
View/download PDF

14. Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan

Author

Diao, Daojun, primary, Wang, Hu, additional, Li, Tangliang, additional, Shi, Zhencan, additional, Jin, Xiaoqing, additional, Sperka, Tobias, additional, Zhu, Xudong, additional, Zhang, Meimei, additional, Yang, Fan, additional, Cong, Yusheng, additional, Shen, Li, additional, Zhan, Qimin, additional, Yan, Jing, additional, Song, Zhangfa, additional, and Ju, Zhenyu, additional

Published
2018
Full Text
View/download PDF

15. Author Correction: HuR regulates telomerase activity through TERC methylation

Author

Tang, Hao, primary, Wang, Hu, additional, Cheng, Xiaolei, additional, Fan, Xiuqin, additional, Yang, Fan, additional, Zhang, Mengmeng, additional, Chen, Yanlian, additional, Tian, Yuyang, additional, Liu, Cihang, additional, Shao, Dongxing, additional, Jiang, Bin, additional, Dou, Yali, additional, Cong, Yusheng, additional, Xing, Junyue, additional, Zhang, Xiaotian, additional, Yi, Xia, additional, Songyang, Zhou, additional, Ma, Wenbin, additional, Zhao, Yong, additional, Wang, Xian, additional, Ma, Jinbiao, additional, Gorospe, Myriam, additional, Ju, Zhenyu, additional, and Wang, Wengong, additional

Published
2018
Full Text
View/download PDF

16. HuR regulates telomerase activity through TERC methylation

Author

Tang, Hao, primary, Wang, Hu, additional, Cheng, Xiaolei, additional, Fan, Xiuqin, additional, Yang, Fan, additional, Zhang, Mengmeng, additional, Chen, Yanlian, additional, Tian, Yuyang, additional, Liu, Cihang, additional, Shao, Dongxing, additional, Jiang, Bin, additional, Dou, Yali, additional, Cong, Yusheng, additional, Xing, Junyue, additional, Zhang, Xiaotian, additional, Yi, Xia, additional, Songyang, Zhou, additional, Ma, Wenbin, additional, Zhao, Yong, additional, Wang, Xian, additional, Ma, Jinbiao, additional, Gorospe, Myriam, additional, Ju, Zhenyu, additional, and Wang, Wengong, additional

Published
2018
Full Text
View/download PDF

23. Isolating lipid droplets from multiple species

Author

Ding, Yunfeng, primary, Zhang, Shuyan, additional, Yang, Li, additional, Na, Huimin, additional, Zhang, Peng, additional, Zhang, Huina, additional, Wang, Yang, additional, Chen, Yong, additional, Yu, Jinhai, additional, Huo, Chaoxing, additional, Xu, Shimeng, additional, Garaiova, Martina, additional, Cong, Yusheng, additional, and Liu, Pingsheng, additional

Published
2012
Full Text
View/download PDF

25. Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression

Author

Li, Song, primary, Guo, Bin, additional, Song, Jianwen, additional, Deng, Xiaoli, additional, Cong, Yusheng, additional, Li, Pengfei, additional, Zhao, Ke, additional, Liu, Lihong, additional, Xiao, Gang, additional, Xu, Feng, additional, Ye, Yingjiang, additional, Zhao, Zhenwen, additional, Yu, Menggang, additional, Xu, Yan, additional, Sang, Jianli, additional, and Zhang, Junjie, additional

Published
2012
Full Text
View/download PDF

27. Isolating lipid droplets from multiple species

Author

Ding, Yunfeng, Zhang, Shuyan, Yang, Li, Na, Huimin, Zhang, Peng, Zhang, Huina, Wang, Yang, Chen, Yong, Yu, Jinhai, Huo, Chaoxing, Xu, Shimeng, Garaiova, Martina, Cong, Yusheng, and Liu, Pingsheng

Abstract

The lipid droplet (LD) is a cell organelle that has been linked to human metabolic syndromes and that can be exploited for the development of biofuels. The isolation of LDs is crucial for carrying out morphological and biochemical studies of this organelle. In the past two decades, LDs have been isolated from several organisms and investigated by microscopy, proteomics and lipidomics. However, these studies need to be extended to more model organisms, as well as to more animal tissues. Thus, a standard method that can be easily applied to these new samples with the need for minimal optimization is essential. Here we provide an LD isolation protocol that is relatively simple and suitable for a wide range of tissues and organisms. On the basis of previous studies, this 7-h protocol can yield 15–100 μg of protein-equivalent high-quality LDs that satisfy the requirements for current LD research in most organisms.

Published
2013
Full Text
View/download PDF

28. RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis.

Author

Xiao L, Wang J, Li J, Chen X, Xu P, Sun S, He D, Cong Y, and Zhai Y

Subjects
3T3 Cells, Adipocytes physiology, Animals, Cell Line, Tumor, Cell Movement drug effects, Cell Proliferation drug effects, Cell Survival drug effects, Cell Survival physiology, Chick Embryo, Chorioallantoic Membrane blood supply, Chorioallantoic Membrane drug effects, Colorectal Neoplasms pathology, Humans, Mice, Neovascularization, Physiologic drug effects, Neovascularization, Physiologic physiology, Nuclear Receptor Subfamily 1, Group F, Member 1 antagonists & inhibitors, Cell Movement physiology, Cell Proliferation physiology, Chorioallantoic Membrane physiology, Colorectal Neoplasms metabolism, Culture Media, Conditioned pharmacology, Nuclear Receptor Subfamily 1, Group F, Member 1 biosynthesis
Abstract

Lipid metabolic disturbances are related to many diseases, such as obesity, diabetes, and certain cancers. Notably, lipid metabolic disturbances have been reported to be a risk factor for colorectal cancer. Nuclear receptors act as ligand-dependent transcription regulators and play key roles in the regulation of body lipid metabolism and the development of many cancers. Retinoic acid receptor-related orphan receptor α (RORα) is a nuclear receptor and can regulate several lipid metabolism genes in certain cancers. Herein, we demonstrate that the conditioned medium from adipocytes has a proproliferative and promigratory effect on colorectal cancer cells and enhances angiogenesis in chicken embryonic chorioallantoic membranes. In addition, the conditioned medium leads to a decrease in the expression of RORα and its target genes. Meanwhile, RORα and its target gene expressions are lower in human colorectal tumor tissue compared with control colorectal tissue. Activation of RORα inhibits the effect of conditioned medium on the proliferation and migration of colorectal cancer cells as well as the angiogenesis in chicken embryonic allantoic membranes. In colorectal cancer cells, the putative ligand of RORα, cholesterol sulfate (CS), prevents cell cycle progression at the G1/S boundary and concurrently modulates the expression of cell cycle-regulatory genes in colorectal cancer cell. CS inhibits angiogenesis in chicken embryonic chorioallantoic membranes and concurrently decreases the mRNA expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α as well as the secretion of VEGF. In addition, lipogenic gene expression is higher in human colorectal tumor tissue compared with control colorectal tissue. CS inhibits the expression of lipogenic genes in colorectal cancer cells. These results suggest that RORα could represent a direct link between local lipid metabolism of colorectal tissue and colorectal cancer. Therefore, the reduction of the expression of RORα could represent a potential warning sign of colorectal cancer., (Copyright © 2015 the American Physiological Society.)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results