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1. Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins

Author

Wolnick, Nicolas Q., Dickson, Marissa R., Webster, Thaddaeus A., Connolly, Roger P., Fernandes, Nancy, Encheva, Vesela, Crittenden, Hunter, Hodgkins, Jessica, Hadley, Brian C., Palermo, Gabriella, Hendrick, Shannon J., Newell, Roy A., Gray, Genevieve, Siltanen, Christian, Armstrong, Julia, Downey, Brandon J., and Mason, Carrie

Published
2024
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5. An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers

Author

Olin, Mikayla, primary, Wolnick, Nicolas, additional, Crittenden, Hunter, additional, Quach, Anthony, additional, Russell, Brian, additional, Hendrick, Shannon, additional, Armstrong, Julia, additional, Webster, Thaddaeus, additional, Hadley, Brian, additional, Dickson, Marissa, additional, Hodgkins, Jessica, additional, Busa, Kevin, additional, Connolly, Roger, additional, and Downey, Brandon, additional

Published
2023
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6. An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers.

Author

Olin, Mikayla, Wolnick, Nicolas, Crittenden, Hunter, Quach, Anthony, Russell, Brian, Hendrick, Shannon, Armstrong, Julia, Webster, Thaddaeus, Hadley, Brian, Dickson, Marissa, Hodgkins, Jessica, Busa, Kevin, Connolly, Roger, and Downey, Brandon

Subjects
MONOCLONAL antibodies, CHO cell, VACCINATION, TITERS, PERFUSION, RAMAN spectroscopy, ANIMAL feeds
Abstract

An important consideration for biopharmaceutical processes is the cost of goods (CoGs) of biotherapeutics manufacturing. CoGs can be reduced by dramatically increasing the productivity of the bioreactor process. In this study, we demonstrate that an intensified process which couples a perfused N‐1 seed reactor and a fully automated high inoculation density (HID) N stage reactor substantially increases the bioreactor productivity as compared to a low inoculation density (LID) control fed‐batch process. A panel of six CHOK1SV GS‐KO® CHO cell lines expressing three different monoclonal antibodies was evaluated in this intensified process, achieving an average 85% titer increase and 132% space–time yield (STY) increase was demonstrated when comparing the 12‐day HID process to a 15‐day LID control process. These productivity increases were enabled by automated nutrient feeding in both the N‐1 and N stage bioreactors using in‐line process analytical technologies (PAT) and feedback control. The N‐1 bioreactor utilized in‐line capacitance to automatically feed the bioreactor based on a capacitance‐specific perfusion rate (CapSPR). The N‐stage bioreactor utilized in‐line Raman spectroscopy to estimate real‐time concentrations of glucose, phenylalanine, and methionine, which are held to target set points using automatic feed additions. These automated feeding methodologies were shown to be generalizable across six cell lines with diverse feed requirements. We show this new process can accommodate clonal diversity and reproducibly achieve substantial titer uplifts compared to traditional cell culture processes, thereby establishing a baseline technology platform upon which further increases bioreactor productivity and CoGs reduction can be achieved. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Iodbasedow : the response in an iodine deficient population to an increase in iodine consumption

Author

Connolly, Roger

Abstract

Endemic goitre due mainly to iodine deficiency has been recorded in many areas of the world throughout history and its response to crude iodine preparations has been noted. The good effect of the pure element in the treatment of goitre was modified by severe thyrotoxic reactions, reported particularly from areas of endemic goitre. A rational basis for the use of iodine in prophylaxis against goitre, came with the discoveries linking iodine with thyroid metabolism and measurements of low iodine concentrations in water, soil and plants. Mountainous areas which are far from the sea and have been subjected to glaciation in the last Ice Age are particularly prone to iodine deficiency. The excellent response to iodine prophylaxis in preventing goitre in the children of Ohio, U.S.A. was followed by an equally good one in Switzerland. However there were further reports of thyrotoxicosis following iodine prophylaxis again occurring in adult goitrous females. It was thought by those who believed that iodine caused thyrotoxicosis in some people, that the size of' thedose given was important but examples suggest that this was not so. Indeed many authorities denied the existence of iodbasedow. Tasmania has been a very satisfactory area to observe these phenomena. Population shifts are minimal and it was a moderately iodine deficient island with a goitre incidence among adult females of approximately 30 per cent. Although goitregens were pro- posed as a contributing cause of goitre none such have been found. Iodation of bread gave universal prophylaxis to the population and an excellent response has been achieved. Goitre prevalence in children has fallen to that seen in countries where goitre is not endemic. The pathology of goitre in Tasmania is similar to that seen in all parts of the world. There does not seem to be any increased incidence of thyroid cancer, cretinism is rare and before iodation of bread the incidence of thyrotoxicosis was lower than that recorded in iodine sufficient communities. Several factors have combined to produce a change in iodine content in the environment of Tasmania, before iodation of bread. The importation of large amounts of food from areas of Australia which are not iodine deficient and the use of iodophors in the food industry provided extra iodine. Several other sources of iodine were brought to Tasmania resulting in a gradual increase in iodine consumption. A steady increase in the incidence of thyrotoxicosis was noticed from 1960, as shown in Fig. 10-2 with a sudden rise which has continued from 1966 when bread was iodated. It is suggested that the incidence of thyrotoxicosis has risen to that occurring in nonendemic goitre areas, previous iodine deficiency having protected those otherwise prone to develope the disease. If this is so, the incidence will remain similar to that of the average world incidence for non-endemic goitre areas, but the age group affected should become progressively younger. The addition of iodine to the diet of the population of Tasmania can be justified by the disappearance of goitre and consequent decrease in thyrocardiac disease which is associated with nodular goitre in middle age, the probable disappearance of . lethal cancer of the thyroid in the elderly, tracheal obstruction by retrosternal goitre and the cosmetic effect in females who formed the majority affected by the condition. It is predicted that the price for this will be a slight increase in the incidence of thyrotoxicosis in an age group which will become progressively younger and more able to cope with the disease. On balance at the present time this price is reasonable. Evidence to support these assumptions are presented in the body of the thesis.

Published
2023
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10. RHIC Au-Au Operation at 100 GeV in Run16

Author

Gu, Xiaofeng, Alessi, James, Beebe, Edward, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Butler, John, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fischer, Wolfram, Gardner, Chris, Gassner, David, Hao, Yue, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Ingrassia, Peter, Jamilkowski, James, Laster, Jonathan, Litvinenko, Vladimir, Liu, Chuyu, Luo, Yun, Mapes, Michael, Marr, Gregory, Marusic, Al, McIntyre, Gary, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Naylor, Christopher, Nemesure, Seth, Pinayev, Igor, Ranjbar, Vahid, Raparia, Deepak, Robert-Demolaize, Guillaume, Roser, Thomas, Sampson, Paul, Sandberg, Jon, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Than, Roberto, Thieberger, Peter, Tuozzolo, Joseph, Wang, Gang, Wu, Qiong, Zaltsman, Alex, Zeno, Keith, Zhang, S., and Zhang, Wu

Subjects
1: Circular and Linear Colliders, Physics::Accelerator Physics, Nuclear Experiment, Accelerator Physics
Abstract

In order to achieve higher instantaneous and integrated luminosities, the average Au bunch intensity in RHIC has been increased by 30% compared to the preceding Au run. This increase was accomplished by merging bunches in the RHIC injector AGS. Luminosity leveling for one of the two interaction points (IP) with collisions was realized by continuous control of the vertical beam separation. Parallel to RHIC physics operation, the electron beam commissioning of a novel cooling technique with potential application in eRHIC, Coherent electron Cooling as a proof of principle (CeCPoP), was carried out. In addition, a 56 MHz superconducting RF cavity was commissioned and made operational. In this paper we will focus on the RHIC performance during the 2016 Au-Au run., Proceedings of the North American Particle Accelerator Conf., NAPAC2016, Chicago, IL, USA

Published
2017
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11. Beam energy scan with asymmetric collision at RHIC

Author

Liu, Chuyu, Alessi, James, Beebe, Edward, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Butler, John, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fischer, Wolfram, Gardner, Chris, Gassner, David, Gu, Xiaofeng, Hao, Yue, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Ingrassia, Peter, Jamilkowski, James, Laster, Jonathan, Litvinenko, Vladimir, Luo, Yun, Mapes, Michael, Marr, Gregory, Marusic, Al, McIntyre, Gary, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Naylor, Christopher, Nemesure, Seth, Pinayev, Igor, Ranjbar, Vahid, Raparia, Deepak, Robert-Demolaize, Guillaume, Roser, Thomas, Sampson, Paul, Sandberg, Jon, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Than, Roberto, Thieberger, Peter, Tuozzolo, Joseph, Wang, Gang, Wu, Qiong, Zaltsman, Alex, Zeno, Keith, Zhang, S., and Zhang, Wu

Subjects
Nuclear Theory, Nuclear Experiment, 01 Circular and Linear Colliders, Accelerator Physics
Abstract

A beam energy scan of deuteron-gold collision, with center-of-mass energy at 19.6, 39, 62.4 and 200.7 GeV/n, was performed at the Relativistic Heavy Ion Collider in 2016 to study the threshold for quark-gluon plasma (QGP) production. The lattice, RF, stochastic cooling and other subsystems were in different configurations for the various energies. The operational challenges changed with every new energy. The operational experience at each energy, the operation performance, highlights and lessons of the beam energy scan are reviewed in this report., Proceedings of the 8th Int. Particle Accelerator Conf., IPAC2017, Copenhagen, Denmark

Published
2016
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14. RHIC Operation with Asymmetric Collisions in 2015

Author

Liu, Chuyu, Aschenauer, Elke, Atoian, Grigor, Blaskiewicz, Michael, Brown, Kevin, Bruno, Donald, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fischer, Wolfram, Gardner, Chris, Gu, Xiaofeng, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Laster, Jonathan, Luo, Yun, Makdisi, Yousef, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Narayan, Geetha, Nayak, Sumanta, Nemesure, Seth, Pile, Philip, Poblaguev, Andrei, Ranjbar, Vahid, Robert-Demolaize, Guillaume, Roser, Thomas, Schmidke, William, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Trbojevic, Dejan, Tsoupas, Nicholaos, Wang, Gang, White, Simon, Yip, Kin, Zaltsman, Alex, Zeno, Keith, and Zhang, S.

Subjects
Physics::Accelerator Physics, Nuclear Experiment, 01 Circular and Linear Colliders, Accelerator Physics
Abstract

Collisions with beams of highly asymmetric rigidities (proton-Gold and proton-Aluminum) were provided for the RHIC physics programs in 2015. Magnets were moved for the first time in RHIC prior to the run to accommodate the asymmetric beam trajectories during acceleration and at store. A special ramping scheme was designed to keep the revolution frequencies of the beams in the two rings equal. The unique operational experience of the asymmetric run will be reviewed., Proceedings of the 7th Int. Particle Accelerator Conf., IPAC2016, Busan, Korea

Published
2016
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17. RHIC Polarized Proton-Proton Operation at 100 GeV in Run 15

Author

Schoefer, Vincent, Aschenauer, Elke, Atoian, Grigor, Blaskiewicz, Michael, Brown, Kevin, Bruno, Donald, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Dutheil, Yann, Fischer, Wolfram, Gardner, Chris, Gu, Xiaofeng, Hayes, Thomas, Huang, Haixin, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Makdisi, Yousef, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Nemesure, Seth, Pile, Philip, Poblaguev, Andrei, Ranjbar, Vahid, Robert-Demolaize, Guillaume, Roser, Thomas, Schmidke, William, Severino, Freddy, Shrey, Travis, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Trbojevic, Dejan, Tsoupas, Nicholaos, Tuozzolo, Joseph, Wang, Gang, White, Simon, Yip, Kin, Zaltsman, Alex, Zelenski, Anatoli, Zeno, Keith, and Zhang, S.

Subjects
1: Circular and Linear Colliders, Physics::Accelerator Physics, Accelerator Physics
Abstract

The first part of RHIC Run 15 consisted of nine weeks of polarized proton on proton collisions at a beam energy of 100 GeV at two interaction points. In this paper we discuss several of the upgrades to the collider complex that allowed for improved performance this run. The largest effort consisted of commissioning of the electron lenses, one in each ring, which are designed to compensate one of the two beam-beam interactions experienced by the proton bunches. The e-lenses therefore raise the per bunch intensity at which luminosity becomes beam-beam limited. A new lattice was designed to create the phase advances necessary for a functioning e-lens which also has an improved off-momentum dynamic aperture relative to previous runs. In order to take advantage of the new, higher intensity limit without suffering intensity driven emittance deterioration, other features were commissioned including a continuous transverse bunch-by-bunch damper in RHIC and a double harmonic capture scheme in the Booster. Other high intensity protections include improvements to the abort system and the installation of masks to intercept beam lost due to abort kicker pre-fires., Proceedings of the 6th Int. Particle Accelerator Conf., IPAC2015, Richmond, VA, USA

Published
2015
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18. RHIC Performance during the 7.5 GeV Low Energy Run in FY 2014

Author

Montag, Christoph, Bai, Mei, Beebe-Wang, Joanne, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fischer, Wolfram, Gardner, Chris, Gu, Xiaofeng, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Makdisi, Yousef, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Morris, John, Nemesure, Seth, Piacentino, Joseph, Pile, Philip, Ranjbar, Vahid, Robert-Demolaize, Guillaume, Roser, Thomas, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Thieberger, Peter, Tuozzolo, Joseph, Wilinski, Michelle, Yip, Kin, Zaltsman, Alex, Zeno, Keith, and Zhang, Wu

Subjects
A01 Hadron Colliders, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment, 01 Circular and Linear Colliders, Accelerator Physics
Abstract

As the last missing step in phase 1 of the beam energy scan (BES-I), aimed at the search for the critical point in the QCD phase diagram, RHIC collided gold ions at a beam energy of 7.3 GeV/nucleon during the FY 2014 run. While this particular energy is close to the nominal RHIC injection energy of 9.8 GeV/nucleon, it is nevertheless challenging because it happens to be close to the AGS transition energy, which makes longitudinal beam dynamics during transfer from the AGS to RHIC difficult. We report on machine performance, obstacles and solutions during the FY 2014 low energy run., Proceedings of the 5th Int. Particle Accelerator Conf., IPAC2014, Dresden, Germany

Published
2014
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19. Beam Diagnostics for the BNL Energy Recovery Linac Test Facility.

Author

Cameron, Peter, Ben-Zvi, Ilan, Blaskiewicz, Michael, Brennan, Michael, Connolly, Roger, Dawson, William, Degen, Chris, DellaPenna, Al, Gassner, David, Kesselman, Martin, Kewish, Jorg, Litvinenko, Vladimir, Mead, Joseph, Oerter, Brian, Russo, Tom, Vetter, Kurt, and Yakimenko, Vitaly

Subjects
ELECTRON beams, LINEAR accelerators, PARTICLE accelerators, ELECTRON optics, PHOTOCATHODES, SUPERCONDUCTORS
Abstract

An Energy Recovery Linac (ERL) test facility is presently under construction at BNL. The goals of this test facility are first to demonstrate stable intense CW electron beam with parameters typical for the RHIC e-cooling project (and potentially for eRHIC), second to test novel elements of the ERL (high current CW photo-cathode, superconducting RF cavity with HOM dampers, and feedback systems), and finally to test lattice dependence of stability criteria. Planned diagnostics include position monitors, loss monitors, transverse profile monitors (both optical and wires), scrapers/halo monitors, a high resolution differential current monitor, phase monitors, an energy spread monitor, and a fast transverse monitor (for beam break-up studies and the energy feedback system). We discuss diagnostics challenges that are unique to this project, and present preliminary system specifications. In addition, we include a brief discussion of the timing system. © 2004 American Institute of Physics [ABSTRACT FROM AUTHOR]

Published
2004
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21. LETTERS.

Author

Crain, Janet, Chan, Edward, Julien, Hershey, Couling, Denise, Khan, Muhammed, Garcia Jr., Jesus, Tapley, Hollie, Kropfli, Bob, Schaaf, Barbara, McGinnis, Bill, McCallan, William, Connolly, Roger, and Calkins, Cyndy

Subjects
LETTERS to the editor, WORLD health, INTERNATIONAL cooperation
Abstract

The article presents letters to the editor in response to the November 7, 2005 edition of "Time." The edition focused on the work being done to prevent disease and fight poverty worldwide.

Published
2005

22. RHIC performance for FY'10 200 GeV Au+Au heavy ion run

Author

Brown, Kevin, Ahrens, Leif, Bai, Mei, Beebe-Wang, Joanne, Blaskiewicz, Michael, Brennan, Joseph, Bruno, Donald, Carlson, Charles, Connolly, Roger, D Ottavio, Ted, Maria, Riccardo, Drees, Angelika, Fischer, Wolfram, Fu, Wenge, Gardner, Chris, Gassner, David, Glenn, Joseph, Hao, Yue, Harvey, Margaret, Hayes, Thomas, Hoff, Lawrence, Huang, Haixin, Laster, Jonathan, Lee, Roger, Litvinenko, Vladimir, Luo, Yun, Mackay, William, Mapes, Michael, Marr, Gregory, Marusic, Al, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Nemesure, Seth, Oerter, Brian, Pilat, Fulvia, Ptitsyn, Vadim, Robert-Demolaize, Guillaume, Thomas Roser, Russo, Thomas, Sampson, Paul, Sandberg, Jon, Satogata, Todd, Schoefer, Vincent, Schultheiss, Carl, Severino, Freddy, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Theisen, Charles, Thieberger, Peter, Trbojevic, Dejan, Tsoupas, Nicholaos, Tuozzolo, Joseph, Wang, Gang, Wilinski, Michelle, Zaltsman, Alex, Zeno, Keith, and Zhang, S. Y.

23. First RHIC collider test operation at 2.5gev beam energy

Author

Montag, Christoph, Ahrens, Leif, Bai, Mei, Beebe-Wang, Joanne, Blackler, Ian, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, D Ottavio, Ted, Drees, Kirsten, Fischer, Wolfram, Gardner, Chris, Gu, Xiaofeng, Harvey, Margaret, Hayes, Thomas, Hoff, Lawrence, Huang, Haixin, Hulsart, Robert, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Morris, John, Nemesure, Seth, Ranjbar, Vahid, Robert-Demolaize, Guillaume, Thomas Roser, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Tuozzolo, Joseph, Wilinski, Michelle, Zaltsman, Alex, Zeno, Keith, and Zhang, Wu

24. RHIC Performance as a 100 GeV Polarized Proton Collider in Run-9

Author

Montag, Christoph, Ahrens, Leif, Bai, Mei, Beebe-Wang, Joanne, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fedotov, Alexei, Fischer, Wolfram, Ganetis, George, Gardner, Chris, Glenn, Joseph, Hahn, Harald, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Ingrassia, Peter, Jamilkowski, James, Kayran, Dmitry, Kewisch, Jorg, Lee, Roger, Lowenstein, Derek, Luccio, Alfredo, Luo, Yun, MacKay, William, Makdisi, Yousef, Malitsky, Nikolay, Marr, Gregory, Marusic, Al, Menga, Matthew, Michnoff, Robert, Minty, Michiko, Morris, John, Oerter, Brian, Pilat, Fulvia, Pile, Philip, Pozdeyev, Eduard, Ptitsyn, Vadim, Robert-Demolaize, Guillaume, Roser, Thomas, Russo, Thomas, Satogata, Todd, Schoefer, Vincent, Schultheiss, Carl, Severino, Freddy, Sivertz, Michael, Smith, Kevin, Tepikian, Steven, Thieberger, Peter, Trbojevic, Dejan, Tsoupas, Nicholaos, Tuozzolo, Joseph, Zaltsman, Alex, Zelenski, Anatoli, Zeno, Keith, and Zhang, S.Y.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, A01 Hadron Colliders, High Energy Physics::Experiment, Astrophysics::Cosmology and Extragalactic Astrophysics, Nuclear Experiment, Accelerator Physics, 01 Circular Colliders
Abstract

During the second half of Run-9, the Relativistic Heavy Ion Collider (RHIC) provided polarized proton collisions at two interaction points with both longitudinal and vertical spin direction. Despite an increase in the peak luminosity by up to 40%, the average store luminosity did not increase compared to previous runs. We discuss the luminosity limitations and polarization performance during Run-9., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

25. Overcoming the horizontal depolarizing resonance in the brookhaven AGS

Author

Huang, Haixin, Ahrens, Leif, Bai, Mei, Blaskiewicz, Michael, Brown, Kevin, Connolly, Roger, Dutheil, Yann, Fischer, Wolfram, Gardner, Chris, Glenn, Joseph, Hayes, Thomas, Méot, Francois, Poblaguev, Andrei, Ranjbar, Vahid, Roser, Thomas, Schoefer, Vincent, Smith, Kevin, Tepikian, Steven, Tsoupas, Nicholaos, Yip, Kin, Zelenski, Anatoli, Zeno, Keith, and Zhang, S.

Subjects
Physics::Accelerator Physics, 04 Hadron Accelerators, A04 Circular Accelerators, Accelerator Physics
Abstract

Imperfection and vertical intrinsic depolarizing resonances have been overcome by the two partial Siberian snakes in the AGS. The relatively weak but numerous horizontal resonances are the main source of polarization loss in the AGS. A pair of horizontal quads have been used to overcome these weak resonances. This technique needs very accurate jump timing. Fast roll-over magnet cycle has been used and it improves the polarization transmission efficiency near extraction when acceleration usually is slowing down. Emittance preservation is also important to mitigate polarization loss. Recent experimental results including jump quad timing and emittance preservation are presented in this paper., Proceedings of the 5th Int. Particle Accelerator Conf., IPAC2014, Dresden, Germany

26. RHIC performance with stochastic cooling for ions and head-on beam-beam compensation for protons

Author

Fischer, Wolfram, Alessi, James, Altinbas, Zeynep, Aschenauer, Elke, Atoian, Grigor, Bai, Mei, Beebe, Edward, Binello, Severino, Blackler, Ian, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, Costanzo, Michael, D'Ottavio, Ted, Drees, Kirsten, Dutheil, Yann, Fedotov, Alexei, Gardner, Chris, Gassner, David, Gu, Xiaofeng, Harper, Caitlin, Harvey, Margaret, Hayes, Thomas, Hock, Jon, Huang, Haixin, Hulsart, Robert, Jamilkowski, James, Kanesue, Takeshi, Kling, Nicholas, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Maffei, David, Makdisi, Yousef, Mapes, Michael, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Miller, Toby, Minty, Michiko, Montag, Christoph, Morris, John, Narayan, Geetha, Naylor, Christopher, Nemesure, Seth, Okamura, Masahiro, Perez, Shawn, Pikin, Alexander, Pile, Philip, Poblaguev, Andrei, Ptitsyn, Vadim, Ranjbar, Vahid, Raparia, Deepak, Robert-Demolaize, Guillaume, Roser, Thomas, Sandberg, Jon, Schmidke, William, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Than, Roberto, Thieberger, Peter, Tuozzolo, Joseph, Van Kuik, Brian, Wang, Gang, White, Simon, Yip, Kin, Zaltsman, Alex, Zelenski, Anatoli, Zeno, Keith, and Zhang, Wu

Subjects
Physics::Accelerator Physics, Nuclear Experiment, 01 Circular and Linear Colliders, Accelerator Physics
Abstract

The Relativistic Heavy Ion Collider (RHIC) has two main operating modes with heavy ions and polarized protons respectively. In addition to a continuous increase in the bunch intensity in all modes, two major new systems were completed recently mitigating the main luminosity limit and leading to significant performance improvements. For heavy ion operation stochastic cooling mitigates the effects of intrabeam scattering, and for polarized proton operation head-on beam-beam compensation mitigated the beam-beam effect. We present the performance increases with these upgrades for heavy ions and polarized protons, as well as an overview of all operating modes past and planned., Proceedings of the 7th Int. Particle Accelerator Conf., IPAC2016, Busan, Korea

27. The Brookhaven linac Isotope Production (BLIP) facility raster scanning system first year operation with BEAm

Author

Michnoff, Robert, Altinbas, Zeynep, Cerniglia, Phil, Connolly, Roger, Cullen, Christian, Degen, Christopher, Hulsart, Robert, Lambiase, Robert, Mausner, Leonard, Pekrul, Winston, Raparia, Deepak, and Thieberger, Peter

Subjects
Overview and Commissioning, Accelerator Physics
Abstract

Brookhaven National Laboratory's BLIP facility produces radioisotopes for the nuclear medicine community and industry, and performs research to develop new radioisotopes desired by nuclear medicine investigators. A raster scanning system was recently completed in December 2015 and fully commissioned in January 2016 to provide improved beam distribution on the targets, allow higher beam intensities, and ultimately increase production yield of the isotopes. The project included the installation of horizontal and vertical dipole magnets driven at 5 kHz with 90 deg phase separation to produce a circular beam raster pattern, a beam interlock system, and several instrumentation devices including multi-wire profile monitors, a laser profile monitor, beam current transformers and a beam position monitor. The first year operational experiences will be presented., Proceedings of the 5th Int. Beam Instrumentation Conf., IBIC2016, Barcelona, Spain

28. Status and Plans for the Polarized Hadron Collider at RHIC

Author

Bai, Mei, Ahrens, Leif, Aschenauer, Elke, Atoian, Grigor, Beebe-Wang, Joanne, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, D Ottavio, Ted, Drees, Kirsten, Dutheil, Yann, Eyser, Oleg, Fischer, Wolfram, Gardner, Chris, Glenn, Joseph, Gu, Xiaofeng, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Kirleis, Anders, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Makdisi, Yousef, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Nemesure, Seth, Pile, Philip, Poblaguev, Andrei, Ptitsyn, Vadim, Ranjbar, Vahid, Robert-Demolaize, Guillaume, Thomas Roser, Schmidke, William, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smirnov, Dmitri, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Trbojevic, Dejan, Tsoupas, Nicholaos, Tuozzolo, Joseph, Wang, Gang, Wilinski, Michelle, Yip, Kin, Zaltsman, Alex, Zelenski, Anatoli, Zeno, Keith, and Zhang, S.

29. RHIC Polarized Proton Operation for 2013

Author

Ranjbar, Vahid, Ahrens, Leif, Aschenauer, Elke, Bai, Mei, Beebe-Wang, Joanne, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Connolly, Roger, D Ottavio, Ted, Drees, Kirsten, Dutheil, Yann, Fischer, Wolfram, Gardner, Chris, Glenn, Joseph, Gu, Xiaofeng, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Hulsart, Robert, Kirleis, Anders, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Makdisi, Yousef, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Nemesure, Seth, Pile, Philip, Poblaguev, Andrei, Ptitsyn, Vadim, Robert-Demolaize, Guillaume, Thomas Roser, Schmidke, William, Schoefer, Vincent, Severino, Freddy, Shrey, Travis, Smirnov, Dmitri, Smith, Kevin, Steski, Dannie, Tepikian, Steven, Trbojevic, Dejan, Tsoupas, Nicholaos, Tuozzolo, Joseph, Wang, Gang, Wilinski, Michelle, Yip, Kin, Zaltsman, Alex, Zelenski, Anatoli, Zeno, Keith, Zhang, S., and Eyser, Oleg

30. RHIC performance for FY2014 heavy ion run

Author

Robert-Demolaize, Guillaume, Alessi, James, Bai, Mei, Beebe, Edward, Beebe-Wang, Joanne, Belomestnykh, Sergey, Blackler, Ian, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Butler, John, Connolly, Roger, D'Ottavio, Ted, Drees, Kirsten, Fedotov, Alexei, Fischer, Wolfram, Gardner, Chris, Gassner, David, Gu, Xiaofeng, Harvey, Margaret, Hayes, Thomas, Huang, Haixin, Ingrassia, Peter, Jamilkowski, James, Kling, Nicholas, Laster, Jonathan, Liu, Chuyu, Luo, Yun, Maffei, David, Makdisi, Yousef, Mapes, Michael, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Naylor, Christopher, Nemesure, Seth, Pikin, Alexander, Pile, Philip, Ptitsyn, Vadim, Raparia, Deepak, Roser, Thomas, Sampson, Paul, Sandberg, Jon, Schoefer, Vincent, Schultheiss, Carl, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Thieberger, Peter, Trbojevic, Dejan, Tuozzolo, Joseph, Van Kuik, Brian, Wilinski, Michelle, Wu, Qiong, Zaltsman, Alex, Zeno, Keith, and Zhang, Wu

Subjects
A01 Hadron Colliders, Physics::Accelerator Physics, Nuclear Experiment, 01 Circular and Linear Colliders, Accelerator Physics
Abstract

After running uranium-uranium and copper-gold collisions in 2012, the high energy heavy ion run of the Relativistic Heavy Ion Collider (RHIC) for Fiscal Year 14 (Run14) is back to gold-gold (Au-Au) collisions at 100 GeV/nucleon. Following the level of performance achieved in Run12, RHIC is still looking to push both instantaneous and integrated luminosity goals. To that end, a new 56 MHz superconducting RF cavity was installed and commissioned, designed to keep ions in one RF bucket and improve luminosity by allowing a smaller beta function at the interaction point (IP) due to a reduced hourglass effect. The following presents an overview of these changes and reviews the performance of the collider., Proceedings of the 5th Int. Particle Accelerator Conf., IPAC2014, Dresden, Germany

31. RHIC performance for fy2012 heavy ion run

Author

Luo, Yun, Alessi, James, Bai, Mei, Beebe, Edward, Beebe-Wang, Joanne, Blackler, Ian, Blaskiewicz, Michael, Brennan, Joseph, Brown, Kevin, Bruno, Donald, Butler, John, Connolly, Roger, D Ottavio, Ted, Drees, Kirsten, Fedotov, Alexei, Fischer, Wolfram, Gardner, Chris, Gassner, David, Gu, Xiaofeng, Hao, Yue, Harvey, Margaret, Hayes, Thomas, Hoff, Lawrence, Huang, Haixin, Ingrassia, Peter, Jamilkowski, James, Kling, Nicholas, Lafky, Michael, Laster, Jonathan, Liu, Chuyu, Maffei, David, Makdisi, Yousef, Mapes, Michael, Marr, Gregory, Marusic, Al, Méot, Francois, Mernick, Kevin, Michnoff, Robert, Minty, Michiko, Montag, Christoph, Morris, John, Naylor, Christopher, Nemesure, Seth, Pikin, Alexander, Pile, Philip, Ptitsyn, Vadim, Raparia, Deepak, Robert-Demolaize, Guillaume, Thomas Roser, Sampson, Paul, Sandberg, Jon, Schoefer, Vincent, Schultheiss, Carl, Severino, Freddy, Shrey, Travis, Smith, Kevin, Tepikian, Steven, Thieberger, Peter, Trbojevic, Dejan, Tuozzolo, Joseph, Kuik, Brian, Wang, Gang, Wilinski, Michelle, Zaltsman, Alex, Zeno, Keith, Zhang, S., and Zhang, Wu

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