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2. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns

Author

Dreval, Kostiantyn, Hilton, Laura K., Cruz, Manuela, Shaalan, Haya, Ben-Neriah, Susana, Boyle, Merrill, Collinge, Brett, Coyle, Krysta M., Duns, Gerben, Farinha, Pedro, Grande, Bruno M., Meissner, Barbara, Pararajalingam, Prasath, Rushton, Christopher K., Slack, Graham W., Wong, Jasper, Mungall, Andrew J., Marra, Marco A., Connors, Joseph M., Steidl, Christian, Scott, David W., and Morin, Ryan D.

Published
2023
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3. Molecular determinants of clinical outcomes in a real-world diffuse large B-cell lymphoma population

Author

Alduaij, Waleed, Collinge, Brett, Ben-Neriah, Susana, Jiang, Aixiang, Hilton, Laura K., Boyle, Merrill, Meissner, Barbara, Chong, Lauren, Miyata-Takata, Tomoko, Slack, Graham W., Farinha, Pedro, Craig, Jeffrey W., Lytle, Andrew, Savage, Kerry J., Villa, Diego, Gerrie, Alina S., Freeman, Ciara L., Gascoyne, Randy D., Connors, Joseph M., Morin, Ryan D., Sehn, Laurie H., Mungall, Andrew J., Steidl, Christian, and Scott, David W.

Published
2023
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7. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial

Author

Straus, David J, Długosz-Danecka, Monika, Connors, Joseph M, Alekseev, Sergey, Illés, Árpád, Picardi, Marco, Lech-Maranda, Ewa, Feldman, Tatyana, Smolewski, Piotr, Savage, Kerry J, Bartlett, Nancy L, Walewski, Jan, Ramchandren, Radhakrishnan, Zinzani, Pier Luigi, Hutchings, Martin, Munoz, Javier, Lee, Hun Ju, Kim, Won Seog, Advani, Ranjana, Ansell, Stephen M, Younes, Anas, Gallamini, Andrea, Liu, Rachael, Little, Meredith, Fenton, Keenan, Fanale, Michelle, and Radford, John

Published
2021
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10. Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma

Author

Rushton, Christopher K., Arthur, Sarah E., Alcaide, Miguel, Cheung, Matthew, Jiang, Aixiang, Coyle, Krysta M., Cleary, Kirstie L.S., Thomas, Nicole, Hilton, Laura K., Michaud, Neil, Daigle, Scott, Davidson, Jordan, Bushell, Kevin, Yu, Stephen, Rys, Ryan N., Jain, Michael, Shepherd, Lois, Marra, Marco A., Kuruvilla, John, Crump, Michael, Mann, Koren, Assouline, Sarit, Connors, Joseph M., Steidl, Christian, Cragg, Mark S., Scott, David W., Johnson, Nathalie A., and Morin, Ryan D.

Published
2020
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11. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Tobacco, Clinical Research, Urologic Diseases, Lung, Genetics, Rare Diseases, Lung Cancer, Human Genome, Hematology, Cancer, Tobacco Smoke and Health, Prevention, Lymphoma, Adult, Aged, Asian People, Bone Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neoplasms, Osteosarcoma, Polymorphism, Single Nucleotide, Smoking, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, White People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

12. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Humans, Neoplasms, Osteosarcoma, Bone Neoplasms, Testicular Neoplasms, Lung Neoplasms, Kidney Neoplasms, Genetic Predisposition to Disease, Tissue Array Analysis, Smoking, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Urinary Bladder Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

15. TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Author

Ennishi, Daisuke, Healy, Shannon, Bashashati, Ali, Saberi, Saeed, Hother, Christoffer, Mottok, Anja, Chan, Fong Chun, Chong, Lauren, Abraham, Libin, Kridel, Robert, Boyle, Merrill, Meissner, Barbara, Aoki, Tomohiro, Takata, Katsuyoshi, Woolcock, Bruce W., Viganò, Elena, Gold, Michael, Molday, Laurie L., Molday, Robert S., Telenius, Adele, Li, Michael Y., Wretham, Nicole, Dos Santos, Nancy, Wong, Mark, Viller, Natasja N., Uger, Robert A., Duns, Gerben, Baticados, Abigail, Madero, Angel, Bristow, Brianna N., Farinha, Pedro, Slack, Graham W., Ben-Neriah, Susana, Lai, Daniel, Zhang, Allen W., Salehi, Sohrab, Shulha, Hennady P., Chiu, Derek S., Mostafavi, Sara, Gerrie, Alina S., Huang, Da Wei, Rushton, Christopher, Villa, Diego, Sehn, Laurie H., Savage, Kerry J., Mungall, Andrew J., Weng, Andrew P., Bally, Marcel B., Morin, Ryan D., Cohen Freue, Gabriela V., Staudt, Louis M., Connors, Joseph M., Marra, Marco A., Shah, Sohrab P., Gascoyne, Randy D., Scott, David W., and Steidl, Christian

Published
2020
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16. Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma

Author

Mottok, Anja, Hung, Stacy S., Chavez, Elizabeth A., Woolcock, Bruce, Telenius, Adèle, Chong, Lauren C., Meissner, Barbara, Nakamura, Hisae, Rushton, Christopher, Viganò, Elena, Sarkozy, Clementine, Gascoyne, Randy D., Connors, Joseph M., Ben-Neriah, Susana, Mungall, Andrew, Marra, Marco A., Siebert, Reiner, Scott, David W., Savage, Kerry J., and Steidl, Christian

Published
2019
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17. Frontline therapy with bendamustine rituximab (BR) and rituximab cyclophosphamide vincristine prednisone (RCVP) confers similar long-term outcomes in patients with treatment naïve Waldenström macroglobulinemia in a real-world setting: a population-based analysis

Author

Kim, Jowon Laura, Gerrie, Alina S., Savage, Kerry Joane, Villa, Diego, Scott, David, Craig, Jeffrey W., Farinha, Pedro, Skinnider, Brian, Slack, Graham, Connors, Joseph M, Sehn, Laurie H., Venner, Christopher, and Freeman, Ciara L.

Subjects
RITUXIMAB, VINCRISTINE, RESOURCE-limited settings, PREDNISONE, PROGRESSION-free survival
Abstract

We report on outcomes of 111 patients with treatment naïve Waldenström macroglobulinemia (TN WM) treated with frontline bendamustine–rituximab (BR) (n = 57) or rituximab–cyclophosphamide–vincristine–prednisone (RCVP) (n = 54). Median follow-up was 60.7 months (range 1.9–231.6). Median progression-free survival (PFS) was 60.5 months (95% CI 47.6–73.4) for BR and 79.0 months (95% CI 31.3–126.8) for RCVP (p =.96). Median overall survival (OS) was not reached for BR and 153.4 months (95% CI 114.5–192.4) for RCVP (p =.37). While overall and major response rates did not differ between treatment groups, BR had numerically higher rate of very good partial response or better response (51% vs. 37%, p =.30) and complete response (26% vs. 13%, p =.13). RCVP confers comparable outcomes to BR in a real-world population of TN WM patients and remains an effective regimen, particularly when tolerance or frailty is an issue, or in resource-limited settings. [ABSTRACT FROM AUTHOR]

Published
2024
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18. CLL-617 Long Term Outcomes and Secondary Malignancies in 673 Patients Treated With Oral Fludarabine and Intravenous Rituximab (FR) for Chronic Lymphocytic Leukemia (CLL) in British Columbia (BC), CanadaElys

Author

VanderVeer, Elysha, primary, Huang, Steven J.T., additional, Bruyere, Helene, additional, Li, Charles, additional, Ramadan, Khaled, additional, Villa, Diego, additional, Scott, David W., additional, Savage, Kerry J., additional, Connors, Joseph M., additional, Sehn, Laurie H., additional, Toze, Cynthia L., additional, and Gerrie, Alina S., additional

Published
2023
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19. POSTER: HL-353 Long-Term Outcomes of Bulky Classic Hodgkin Lymphoma Managed With a Positron Emission Tomography (PET)-Adapted Approach Demonstrate Excellent Outcomes in PET-Negative Cases

Author

Kim, Jowon L, primary, Villa, Diego, additional, Tonseth, R Petter, additional, Gerrie, Alina S, additional, Wilson, Don, additional, Benard, Francois, additional, Venner, Chris P, additional, Skinnider, Brian, additional, Farinha, Pedro, additional, Slack, Graham W, additional, Scott, David W, additional, Connors, Joseph M, additional, Sehn, Laurie H, additional, and Savage, Kerry J, additional

Published
2023
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20. POSTER: CLL-617 Long Term Outcomes and Secondary Malignancies in 673 Patients Treated With Oral Fludarabine and Intravenous Rituximab (FR) for Chronic Lymphocytic Leukemia (CLL) in British Columbia (BC), CanadaElys

Author

VanderVeer, Elysha, primary, Huang, Steven J.T., additional, Bruyere, Helene, additional, Li, Charles, additional, Ramadan, Khaled, additional, Villa, Diego, additional, Scott, David W., additional, Savage, Kerry J., additional, Connors, Joseph M., additional, Sehn, Laurie H., additional, Toze, Cynthia L., additional, and Gerrie, Alina S., additional

Published
2023
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21. HL-353 Long-Term Outcomes of Bulky Classic Hodgkin Lymphoma Managed With a Positron Emission Tomography (PET)-Adapted Approach Demonstrate Excellent Outcomes in PET-Negative Cases

Author

Kim, Jowon L, primary, Villa, Diego, additional, Tonseth, R Petter, additional, Gerrie, Alina S, additional, Wilson, Don, additional, Benard, Francois, additional, Venner, Chris P, additional, Skinnider, Brian, additional, Farinha, Pedro, additional, Slack, Graham W, additional, Scott, David W, additional, Connors, Joseph M, additional, Sehn, Laurie H, additional, and Savage, Kerry J, additional

Published
2023
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23. Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma

Author

Takata, Katsuyoshi, Chong, Lauren C., Ennishi, Daisuke, Aoki, Tomohiro, Li, Michael Yu, Thakur, Avinash, Healy, Shannon, Vigano, Elena, Dao, Tao, Kwon, Daniel, Duns, Gerben, Nielsen, Julie S., Ben-Neriah, Susana, Tse, Ethan, Hung, Stacy S., Boyle, Merrill, Mun, Sung Soo, Bourne, Christopher M., Woolcock, Bruce, Telenius, Adele, Kishida, Makoto, Rai, Shinya, Zhang, Allen W., Bashashati, Ali, Saberi, Saeed, DAntonio, Gianluca, Nelson, Brad H., Shah, Sohrab P., Hoodless, Pamela A., Melnick, Ari M., Gascoyne, Randy D., Connors, Joseph M., Scheinberg, David A., Beguelin, Wendy, Scott, David W., and Steidl, Christian

Subjects
Oncology, Experimental, Gene mutations -- Research, Immune response -- Genetic aspects, Non-Hodgkin's lymphomas -- Genetic aspects -- Care and treatment, Tumor antigens -- Genetic aspects, Cancer -- Research, Health care industry
Abstract

PRAME is a prominent member of the cancer testis antigen family of proteins, which triggers autologous T cell-mediated immune responses. Integrative genomic analysis in diffuse large B cell lymphoma (DLBCL) uncovered recurrent and highly focal deletions of 22q11.22, including the PRAME gene, which were associated with poor outcome. PRAME-deleted tumors showed cytotoxic T cell immune escape and were associated with cold tumor microenvironments. In addition, PRAME downmodulation was strongly associated with somatic EZH2 Y641 mutations in DLBCL. In turn, PRC2-regulated genes were repressed in isogenic PRAME-KO lymphoma cell lines, and PRAME was found to directly interact with EZH2 as a negative regulator. EZH2 inhibition with EPZ-6438 abrogated these extrinsic and intrinsic effects, leading to PRAME expression and microenvironment restoration in vivo. Our data highlight multiple functions of PRAME during lymphomagenesis and provide a preclinical rationale for synergistic therapies combining epigenetic reprogramming with PRAME-targeted therapies., Introduction The current treatment standard of combined immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) has achieved significant improvement in patient outcomes in diffuse large B cell lymphoma (DLBCL) [...]

Published
2022
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24. A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

Author

Clot, Guillem, Jares, Pedro, Giné, Eva, Navarro, Alba, Royo, Cristina, Pinyol, Magda, Martín-Garcia, David, Demajo, Santiago, Espinet, Blanca, Salar, Antonio, Ferrer, Ana, Muntañola, Ana, Aymerich, Marta, Rauert-Wunderlich, Hilka, Jaffe, Elaine S., Connors, Joseph M., Gascoyne, Randy D., Delabie, Jan, López-Guillermo, Armando, Ott, German, Wright, George W., Staudt, Louis M., Rosenwald, Andreas, Scott, David W., Rimsza, Lisa M., Beà, Sílvia, and Campo, Elías

Published
2018
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25. Treatment strategies, outcomes and prognostic factors in 291 patients with secondary CNS involvement by diffuse large B-cell lymphoma

Author

El-Galaly, Tarec Christoffer, Cheah, Chan Yoon, Bendtsen, Mette Dahl, Nowakowski, Grzegorz S., Kansara, Roopesh, Savage, Kerry J., Connors, Joseph M., Sehn, Laurie H., Goldschmidt, Neta, Shaulov, Adir, Farooq, Umar, Link, Brian K., Ferreri, Andrés J.M., Calimeri, Teresa, Cecchetti, Caterina, Dann, Eldad J., Thompson, Carrie A., Inbar, Tsofia, Maurer, Matthew J., Gade, Inger Lise, Juul, Maja Bech, Hansen, Jakob W., Holmberg, Staffan, Larsen, Thomas S., Cordua, Sabrina, Mikhaeel, N. George, Hutchings, Martin, Seymour, John F., Clausen, Michael Roost, Smith, Daniel, Opat, Stephen, Gilbertson, Michael, Thanarajasingam, Gita, and Villa, Diego

Published
2018
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27. Hodgkin lymphoma

Author

Connors, Joseph M., Cozen, Wendy, Steidl, Christian, Carbone, Antonino, Hoppe, Richard T., Flechtner, Hans-Henning, and Bartlett, Nancy L.

Published
2020
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29. Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact

Author

Ennishi, Daisuke, Mottok, Anja, Ben-Neriah, Susana, Shulha, Hennady P., Farinha, Pedro, Chan, Fong Chun, Meissner, Barbara, Boyle, Merrill, Hother, Christoffer, Kridel, Robert, Lai, Daniel, Saberi, Saeed, Bashashati, Ali, Shah, Sohrab P., Morin, Ryan D., Marra, Marco A., Savage, Kerry J., Sehn, Laurie H., Steidl, Christian, Connors, Joseph M., Gascoyne, Randy D., and Scott, David W.

Published
2017
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30. The number of extranodal sites assessed by PET/CT scan is a powerful predictor of CNS relapse for patients with diffuse large B-cell lymphoma: An international multicenter study of 1532 patients treated with chemoimmunotherapy

Author

El-Galaly, Tarec Christoffer, Villa, Diego, Michaelsen, Thomas Yssing, Hutchings, Martin, Mikhaeel, Nabegh George, Savage, Kerry J., Sehn, Laurie H., Barrington, Sally, Hansen, Jakob W., Smith, Daniel, Rady, Kirsty, Mylam, Karen J., Larsen, Thomas S., Holmberg, Staffan, Juul, Maja B., Cordua, Sabrina, Clausen, Michael R., Jensen, Kristina B., Johnsen, Hans E., Seymour, John F., Connors, Joseph M., de Nully Brown, Peter, Bøgsted, Martin, and Cheah, Chan Y.

Published
2017
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35. Genetic Subdivisions of Follicular Lymphoma Defined by Distinct Coding and non-coding Mutation Patterns

Author

Dreval, Kostiantyn, primary, Hilton, Laura K, additional, Cruz, Manuela, additional, Shaalan, Haya, additional, Ben-Neriah, Susana, additional, Boyle, Merrill, additional, Collinge, Brett J, additional, Coyle, Krysta Mila, additional, Duns, Gerben, additional, Farinha, Pedro, additional, Grande, Bruno, additional, Meissner, Barbara, additional, Pararajalingam, Prasath, additional, Rushton, Christopher K, additional, Slack, Graham W., additional, Wong, Jasper Chun Hei, additional, Mungall, Andrew J, additional, Marra, Marco A, additional, Connors, Joseph M, additional, Steidl, Christian, additional, Scott, David W., additional, and Morin, Ryan D, additional

Published
2023
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36. Supplementary Table S11 and 15 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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37. Supplementary Table S1-3 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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38. Supplementary Table S8-9 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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39. Supplementary Table S12-14 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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40. Supplementary Fig. 3 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

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2023
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41. Supplementary Fig. 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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42. Supplementary Table 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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43. Supplementary Fig. 5 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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44. Supplementary Fig. 4 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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45. Supplementary Methods and Figures from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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46. Supplementary Table S10 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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47. Supplementary Table 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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48. Data from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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49. Supplementary Fig. 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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50. Supplementary Data from Brentuximab Vedotin plus Chemotherapy in North American Subjects with Newly Diagnosed Stage III or IV Hodgkin Lymphoma

Author

Ramchandren, Radhakrishnan, primary, Advani, Ranjana H., primary, Ansell, Stephen M., primary, Bartlett, Nancy L., primary, Chen, Robert, primary, Connors, Joseph M., primary, Feldman, Tatyana, primary, Forero-Torres, Andres, primary, Friedberg, Jonathan W., primary, Gopal, Ajay K., primary, Gordon, Leo I., primary, Kuruvilla, John, primary, Savage, Kerry J., primary, Younes, Anas, primary, Engley, Gerald, primary, Manley, Thomas J., primary, Fenton, Keenan, primary, and Straus, David J., primary

Published
2023
Full Text
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