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290 results on '"Conradie, Francesca"'

1. Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial

Author

Bruinenberg, Paul, Beumont, Maria, Nedelman, Jerry, Li, Mengchun, Zuma-Gwala, Ntokozo, Rajaram, Shakira, Choo, Louise, Wills, Genevive, Betteridge, Matt, Leandra, Leandra, Olugbosi, Morounfolu, Borisov, Sergey, Cevik, Muge, Thompson, Lindsay C, Upton, Caryn, Rolla, Valéria Cavalcanti, Malahleha, Mookho, Mmbaga, Blandina, Ngubane, Nosipho, Abu Bakar, Zamzurina, Rassool, Mohammed, Variava, Ebrahim, Dawson, Rodney, Staples, Suzanne, Lalloo, Umesh, Louw, Cheryl, Conradie, Francesca, Eristavi, Marika, Samoilova, Anastasia, Skornyakov, Sergey N, Ntinginya, Niyanda Elias, Haraka, Frederick, Praygod, George, Mayanja-Kizza, Harriett, Caoili, Janice, Balanag, Vincent, Dalcolmo, Margareth Pretti, McHugh, Timothy, Hunt, Robert, Solanki, Priya, Bateson, Anna, Crook, Angela M, Fabiane, Stella, Timm, Juliano, Sun, Eugene, Spigelman, Melvin, Sloan, Derek J, and Gillespie, Stephen H

Published
2024
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3. Proposed linezolid dosing strategies to minimize adverse events for treatment of extensively drug-resistant tuberculosis

Author

Imperial, Marjorie Z, Nedelman, Jerry R, Conradie, Francesca, and Savic, Rada M

Subjects
Patient Safety, Rare Diseases, Neurosciences, Tuberculosis, Clinical Research, Infectious Diseases, Hematology, Vaccine Related, Peripheral Neuropathy, Neurodegenerative, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Adult, Anemia, Antitubercular Agents, Extensively Drug-Resistant Tuberculosis, Humans, Linezolid, Peripheral Nervous System Diseases, Prospective Studies, Thrombocytopenia, Treatment Outcome, Tuberculosis, Multidrug-Resistant, adverse events, drug-resistant tuberculosis, linezolid, PK-PD modeling, tuberculosis therapeutics, PK–PD modeling, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundWe evaluated Nix-TB trial data (NCT02333799, N = 109) to provide dosing recommendations to potentially minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis. .MethodsA pharmacokinetic model and toxicodynamic models for peripheral neuropathy, hemoglobin, and platelets were developed. Simulations compared safety outcomes for daily linezolid of 1200 and 600 mg, with and without dose adjustments for toxicity. Severe neuropathy was based on symptom scores from the Brief Peripheral Neuropathy Screen. Severe anemia and thrombocytopenia were defined as ≥ grade 3 adverse events according to the NIAID Division of Microbiology and Infectious Disease Adult Toxicity table.ResultsPredicted concentration-time profiles were a major predictor in all toxicodynamic models. Simulations showed higher percentages of patients with severe neuropathy (median, 19%; 90% confidence interval [CI], 17%-22% vs 5%, 4%-7%) and severe anemia (15%, 12%-17% vs 1%, 0%-2%) between 1200 and 600 mg daily linezolid. No differences in severe thrombocytopenia were observed (median, 10% decrease in hemoglobin level after 4 weeks of treatment would have maximum sensitivity (82%) and specificity (84%) for predicting severe anemia. Reducing the dose from 1200 to 600 mg triggered by this marker may prevent 60% (90% CI, 45%-72%) of severe anemia.ConclusionsSimple neuropathy symptom and hemoglobin monitoring may guide linezolid dosing to avoid toxicities, but prospective testing is needed to confirm the benefit-to-risk ratio.

Published
2022

4. A cohort study of post-COVID-19 condition across the Beta, Delta, and Omicron waves in South Africa: 6-month follow-up of hospitalized and nonhospitalized participants

Author

Jassat, Waasila, Mudara, Caroline, Vika, Caroline, Welch, Richard, Arendse, Tracy, Dryden, Murray, Blumberg, Lucille, Mayet, Natalie, Tempia, Stefano, Parker, Arifa, Nel, Jeremy, Perumal, Rubeshan, Groome, Michelle J., Conradie, Francesca, Ndjeka, Norbert, Sigfrid, Louise, Merson, Laura, and Cohen, Cheryl

Published
2023
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5. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement

Author

Domínguez, Jose, Boeree, Martin J., Cambau, Emmanuelle, Chesov, Dumitru, Conradie, Francesca, Cox, Vivian, Dheda, Keertan, Dudnyk, Andrii, Farhat, Maha R., Gagneux, Sebastien, Grobusch, Martin P., Gröschel, Matthias I., Guglielmetti, Lorenzo, Kontsevaya, Irina, Lange, Berit, van Leth, Frank, Lienhardt, Christian, Mandalakas, Anna Maria, Maurer, Florian, Merker, Matthias, Miotto, Paolo, Molina-Moya, Barbara, Morel, Florence, Niemann, Stefan, Veziris, Nicolas, Whitelaw, Andrew, Horsburgh, Charles Robert, Lange, Christoph, Domínguez, José, Boeree, Martin J, Farhat, Maha R, Grobusch, Martin P, Gröschel, Matthias I, Mandalakas, Anna M, Maurer, Florian P, and Horsburgh, Charles R, Jr

Published
2023
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6. Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial

Author

Adilaa, Oyunchimeg, Alexandru, Sofia, Bellenger, Katharine, Bennet, Jaclyn, Bennet, Deborah, Bindroo, Priyanka, Borisagar, Ghanshyam, Cook, Claire, Dalai, Doljinsuren, Davis, Andrew, de Jong, Bouke, Dodds, Wendy, Duckworth, Lynette, Gahima, Nonhlanhla, Gebreegziabher, Belay, Goldfeld, Anne, Hanifa, Mahmud, Hughes, Gareth, Kimuli, Ivan, Komrska, Jan, Lomtadze, Nino, Murphy, Brendan, Mwelase, Thando, Nalunjogi, Joanitah, Patel, Leena, Pirlog, Irina, Qawiy, Ishmael, Rauchenberger, Mary, Rigouts, Leen, Roach, Carol, Rosu, Laura, Santos-Filho, Ezio, Senguttuvan, Thirumaran, Sisay, Million, Sridhar, Rathinam, Srinivasulu, Vignes, Teferi, Mekonnen, Teklu, Helen, Tsegeen, Narangarav, van Amsterdam, Odette, White, Lisa, Whitney, Johanna, Zagd, Chuluunbaatar, Goodall, Ruth L, Meredith, Sarah K, Nunn, Andrew J, Bayissa, Adamu, Bhatnagar, Anuj K, Bronson, Gay, Chiang, Chen-Yuan, Conradie, Francesca, Gurumurthy, Meera, Kirenga, Bruce, Kiria, Nana, Meressa, Daniel, Moodliar, Ronelle, Narendran, Gopalan, Ngubane, Nosipho, Rassool, Mohammed, Sanders, Karen, Solanki, Rajesh, Squire, S Bertel, Torrea, Gabriela, Tsogt, Bazarragchaa, Tudor, Elena, Van Deun, Armand, and Rusen, I D

Published
2022
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8. Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study

Author

Ndjeka, Norbert, Campbell, Jonathon R, Meintjes, Graeme, Maartens, Gary, Schaaf, H Simon, Hughes, Jennifer, Padanilam, Xavier, Reuter, Anja, Romero, Rodolfo, Ismail, Farzana, Enwerem, Martin, Ferreira, Hannetjie, Conradie, Francesca, Naidoo, Kogieleum, and Menzies, Dick

Published
2022
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9. Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial

Author

Asmelash, Aida, Sehurutshi, Alice, Baguma, Allan, Marais, Anita, Kawoozo, Barbarah, Malinga, Bongiwe Prudence, Mirembe, Brenda Gati, Okech, Brenda, Esterhuizen, Bryan, Murombedzi, Caroline, Gadama, Daphne, Hwengwere, Eldinah, Roos, Elizabeth, Magada, Elizabeth S, Shava, Emily, Piwowar-Manning, Estelle, Tahuringana, Eunice, Muhlanga, Felix GS, Conradie, Francesca, Angira, Frank, Nanyonjo, Gertrude, Kistnasami, Girisha, Mvula, Hazzie, Naidoo, Ishana, Horak, Jaco, Jere, Jane, Moodley, Jeeva, Shin, Katie, Nel, Kerry, Bokoch, Kevin, Birungi, Lilian, Emel, Lynda, Monametsi, Maletsatsi, Sibanda, Marvelous, Mutambanengwe, Mercy, Chitukuta, Miria, Matimbira, Moleen, Bhondai-Mhuri, Muchaneta, Sibisi, Ncamsile, Morar, Neetha, Mudzonga, Netsai, Natureeba, Paul, Richardson, Paul, Musara, Petina, Macdonald, Pippa, Nkambule, Rejoice, Mosime, Repelang, White, Rhonda, Berhanu, Ribka, Ncube-Sihlongonyane, Ritha, Sekabira, Rogers, Siva, Samantha, Pillay, Saresha, Govender, Shamelle, Bamweyana, Sheiala, Nzimande, Siyabonga, Innes, Steve, Dadabhai, Sufia, Samandari, Taraz, Tembo, Tchangani, Lungu Mabedi, Thandie, Chirenda, Thandiwe, Chidemo, Tinashe, Mudhune, Victor, Naidoo, Vikesh, Samaneka, Wadzanai, Agyei, Yaw, Musodza, Yeukai, Fourie, Yolandie, Gaffoor, Zakir, Delany-Moretlwe, Sinead, Hughes, James P, Bock, Peter, Ouma, Samuel Gurrion, Hunidzarira, Portia, Kalonji, Dishiki, Kayange, Noel, Makhema, Joseph, Mandima, Patricia, Mathew, Carrie, Spooner, Elizabeth, Mpendo, Juliet, Mukwekwerere, Pamela, Mgodi, Nyaradzo, Ntege, Patricia Nahirya, Nair, Gonasagrie, Nakabiito, Clemensia, Nuwagaba-Biribonwoha, Harriet, Panchia, Ravindre, Singh, Nishanta, Siziba, Bekezela, Farrior, Jennifer, Rose, Scott, Anderson, Peter L, Eshleman, Susan H, Marzinke, Mark A, Hendrix, Craig W, Beigel-Orme, Stephanie, Hosek, Sybil, Tolley, Elizabeth, Sista, Nirupama, Adeyeye, Adeola, Rooney, James F, Rinehart, Alex, Spreen, William R, Smith, Kimberly, Hanscom, Brett, Cohen, Myron S, and Hosseinipour, Mina C

Published
2022
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10. Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal study

Author

Ismail, Nazir Ahmed, Omar, Shaheed Vally, Moultrie, Harry, Bhyat, Zaheda, Conradie, Francesca, Enwerem, M, Ferreira, Hannetjie, Hughes, Jennifer, Joseph, Lavania, Kock, Yulene, Letsaolo, Vancy, Maartens, Gary, Meintjes, Graeme, Ngcamu, Dumisani, Okozi, Nana, Padanilam, Xavier, Reuter, Anja, Romero, Rodolf, Schaaf, Simon, te Riele, Julian, Variava, Ebrahim, van der Meulen, Minty, Ismail, Farzana, and Ndjeka, Norbert

Published
2022
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12. Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study

Author

Penn-Nicholson, Adam, Georghiou, Sophia B, Ciobanu, Nelly, Kazi, Mubin, Bhalla, Manpreet, David, Anura, Conradie, Francesca, Ruhwald, Morten, Crudu, Valeriu, Rodrigues, Camilla, Myneedu, Vithal Prasad, Scott, Lesley, Denkinger, Claudia M, and Schumacher, Samuel G

Published
2022
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13. QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial

Author

Alli, Oladapo, Gottesman, Joan, Guevara, Maria, Hikuam, Chris, Hovind, Laura, Karlsson, Mats, McClaren, Jennifer, McIlleron, Helen, Murtaugh, William, Rolls, Barbara, Shahkolahi, Akbar, Stone, Lynnett, Tegha, Gerald, Tenai, Jacob, Upton, Caryn, Wimbish, Chanelle, Dooley, Kelly E, Rosenkranz, Susan L, Conradie, Francesca, Moran, Laura, Hafner, Richard, von Groote-Bidlingmaier, Florian, Lama, Javier R., Shenje, Justin, De Los Rios, Jorge, Comins, Kyla, Morganroth, Joel, Diacon, Andreas H, Cramer, Yoninah S, Donahue, Kathleen, and Maartens, Gary

Published
2021
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15. Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial

Author

Tweed, Conor D, Dawson, Rodney, Burger, Divan A, Conradie, Almari, Crook, Angela M, Mendel, Carl M, Conradie, Francesca, Diacon, Andreas H, Ntinginya, Nyanda E, Everitt, Daniel E, Haraka, Frederick, Li, Mengchun, van Niekerk, Christo H, Okwera, Alphonse, Rassool, Mohammed S, Reither, Klaus, Sebe, Modulakgotla A, Staples, Suzanne, Variava, Ebrahim, and Spigelman, Melvin

Published
2019
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22. Living donor liver transplant from an HIV-positive mother to her HIV-negative child: opening up new therapeutic options

Author

Botha, Jean, Conradie, Francesca, Etheredge, Harriet, Fabian, June, Duncan, Mary, Haeri Mazanderani, Ahmad, Paximadis, Maria, Maher, Heather, Britz, Russell, Loveland, Jerome, Ströbele, Bernd, Rambarran, Sharan, Mahomed, Adam, Terblanche, Alta, Beretta, Marisa, Brannigan, Liam, Pienaar, Michael, Archibald-Durham, Lindsay, Lang, Allison, and Tiemessen, Caroline T.

Published
2018
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23. A cohort study of Post COVID-19 Condition across the Beta, Delta and Omicron waves in South Africa: 6-month follow up of hospitalised and non-hospitalised participants

Author

Jassat, Waasila, primary, Mudara, Caroline, additional, Vika, Caroline, additional, Welch, Richard, additional, Arendse, Tracy, additional, Dryden, Murray, additional, Blumberg, Lucille, additional, Mayet, Natalie, additional, Tempia, Stefano, additional, Parker, Arifa, additional, Nel, Jeremy, additional, Perumal, Rubeshan, additional, Groome, Michelle J., additional, Conradie, Francesca, additional, Ndjeka, Norbert, additional, Sigfrid, Louise, additional, Merson, Laura, additional, and Cohen, Cheryl, additional

Published
2022
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24. Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial

Author

Goodall, Ruth L, primary, Meredith, Sarah K, additional, Nunn, Andrew J, additional, Bayissa, Adamu, additional, Bhatnagar, Anuj K, additional, Bronson, Gay, additional, Chiang, Chen-Yuan, additional, Conradie, Francesca, additional, Gurumurthy, Meera, additional, Kirenga, Bruce, additional, Kiria, Nana, additional, Meressa, Daniel, additional, Moodliar, Ronelle, additional, Narendran, Gopalan, additional, Ngubane, Nosipho, additional, Rassool, Mohammed, additional, Sanders, Karen, additional, Solanki, Rajesh, additional, Squire, S Bertel, additional, Torrea, Gabriela, additional, Tsogt, Bazarragchaa, additional, Tudor, Elena, additional, Van Deun, Armand, additional, Rusen, I D, additional, Adilaa, Oyunchimeg, additional, Alexandru, Sofia, additional, Bellenger, Katharine, additional, Bennet, Jaclyn, additional, Bennet, Deborah, additional, Bindroo, Priyanka, additional, Borisagar, Ghanshyam, additional, Cook, Claire, additional, Dalai, Doljinsuren, additional, Davis, Andrew, additional, de Jong, Bouke, additional, Dodds, Wendy, additional, Duckworth, Lynette, additional, Gahima, Nonhlanhla, additional, Gebreegziabher, Belay, additional, Goldfeld, Anne, additional, Hanifa, Mahmud, additional, Hughes, Gareth, additional, Kimuli, Ivan, additional, Komrska, Jan, additional, Lomtadze, Nino, additional, Murphy, Brendan, additional, Mwelase, Thando, additional, Nalunjogi, Joanitah, additional, Patel, Leena, additional, Pirlog, Irina, additional, Qawiy, Ishmael, additional, Rauchenberger, Mary, additional, Rigouts, Leen, additional, Roach, Carol, additional, Rosu, Laura, additional, Santos-Filho, Ezio, additional, Senguttuvan, Thirumaran, additional, Sisay, Million, additional, Sridhar, Rathinam, additional, Srinivasulu, Vignes, additional, Teferi, Mekonnen, additional, Teklu, Helen, additional, Tsegeen, Narangarav, additional, van Amsterdam, Odette, additional, White, Lisa, additional, Whitney, Johanna, additional, and Zagd, Chuluunbaatar, additional

Published
2022
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26. Iqbal Haroon Master, 5 December 1962 - 15 January 2021

Author

Ndjeka, Norbert, Reuter, Anja, Conradie, Francesca, Enwerem, Martin, Ferreira, Hannetjie, Hughes, Jennifer, Ismail, Farzana, Ismail, Nazir, Kock, Yulene, Padanilam, Xavier, Romero, Rodolfo, Schaaf, H Simon, te Riele, Julian, Variava, Ebrahim, Meintjes, Graeme, and Maartens, Gary

Abstract

No Abstract.

Published
2022

27. Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis

Author

Conradie, Francesca, primary, Bagdasaryan, Tatevik R., additional, Borisov, Sergey, additional, Howell, Pauline, additional, Mikiashvili, Lali, additional, Ngubane, Nosipho, additional, Samoilova, Anastasia, additional, Skornykova, Sergey, additional, Tudor, Elena, additional, Variava, Ebrahim, additional, Yablonskiy, Petr, additional, Everitt, Daniel, additional, Wills, Genevieve H., additional, Sun, Eugene, additional, Olugbosi, Morounfolu, additional, Egizi, Erica, additional, Li, Mengchun, additional, Holsta, Alda, additional, Timm, Juliano, additional, Bateson, Anna, additional, Crook, Angela M., additional, Fabiane, Stella M., additional, Hunt, Robert, additional, McHugh, Timothy D., additional, Tweed, Conor D., additional, Foraida, Salah, additional, Mendel, Carl M., additional, and Spigelman, Melvin, additional

Published
2022
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28. Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment (SMARTT): a study protocol for a phase IV pragmatic randomized controlled patient management strategy trial

Author

Van Rie, Annelies, De Vos, Elise, Costa, Emilyn, Verboven, Lennert, Ndebele, Felex, Heupink, Tim, Abrams, Steven, Maraba, Noriah, Makkan, Heeran, Beattie, Trevor, Sibeko, Zandile Rachel, Bohlela, S’thabiso, Segwaba, Pulane, Ogunbayo, Emmanuel Ayodeji, Mhlambi, Nomadlozi, Wells, Felicia, Rigouts, Leen, Maartens, Gary, Conradie, Francesca, Black, John, Potgieter, Sam, Fanampe, Boitumelo, Van der Spoel Van Dyk, Anneke, Charalambous, Salome, Churchyard, Gavin, Warren, Rob, Van Rie, A, De Vos, E, Costa, E, Verboven, Lennert, Ndebele, F, Heupink, TH, ABRAMS, Steven, Fanampe, B, Van Dyk, AV, Charalambous, S, Churchyard, G, Warren, R, and SMARTT team

Subjects
Pragmatic, Whole-genome sequencing, Antitubercular Agents, Medicine (miscellaneous), Clinical Trials, Phase IV as Topic, Mycobacterium, Clinical trial, Strategy trial, Drug resistance, Pragmatic Clinical Trials as Topic, Tuberculosis, Multidrug-Resistant, Tuberculosis, Humans, Pharmacology (medical), Treatment recommender, Human medicine, Neoplasm Recurrence, Local, Rifampin, Algorithms, Randomized Controlled Trials as Topic
Abstract

Background Rifampicin-resistant tuberculosis (RR-TB) remains an important global health problem. Ideally, the complete drug-resistance profile guides individualized treatment for all RR-TB patients, but this is only practised in high-income countries. Implementation of whole genome sequencing (WGS) technologies into routine care in low and middle-income countries has not become a reality due to the expected implementation challenges, including translating WGS results into individualized treatment regimen composition. Methods This trial is a pragmatic, single-blinded, randomized controlled medical device trial of a WGS-guided automated treatment recommendation strategy for individualized treatment of RR-TB. Subjects are 18 years or older and diagnosed with pulmonary RR-TB in four of the five health districts of the Free State province in South Africa. Participants are randomized in a 1:1 ratio to either the intervention (a WGS-guided automated treatment recommendation strategy for individualized treatment of RR-TB) or control (RR-TB treatment according to the national South African guidelines). The primary effectiveness outcome is the bacteriological response to treatment measured as the rate of change in time to liquid culture positivity during the first 6 months of treatment. Secondary effectiveness outcomes include cure rate, relapse rate (recurrence of RR-TB disease) and TB free survival rate in the first 12 months following RR-TB treatment completion. Additional secondary outcomes of interest include safety, the feasibility of province-wide implementation of the strategy into routine care, and health economic assessment from a patient and health systems perspective. Discussion This trial will provide important real-life evidence regarding the feasibility, safety, cost, and effectiveness of a WGS-guided automated treatment recommendation strategy for individualized treatment of RR-TB. Given the pragmatic nature, the trial will assist policymakers in the decision-making regarding the integration of next-generation sequencing technologies into routine RR-TB care in high TB burden settings. Funding The trial is funded by the Research foundation Flanders (FWO) TBM (Applied Biomedical Research with a Primary Social finality) grant number T001018N and FWO Odysseus grant number G0F8316N. The funding body played no role in the design of the study and will not play any role in data collection, analysis, and interpretation of data and in writing the manuscript. Acknowledgements We would like to thank all MDR-TB doctors, MDR-TB nurses, and MDR-TB coordinators of the health districts of the Free State, Noor Zakhura, and Mothusi Masiba for their time and dedication to the study. We also want to thank Keertan Dheda, Gunar Gunther, and Marie-Christin Payen who volunteered to be a member of the data monitoring and safety board. We thank Kelly Dooley and Steven Callens for their contribution to the development of the treatment recommender. We thank Philippe Beutels for his advice on the health economics assessment of the intervention and Ruben Cartuyvels for the development of the treatment recommender web interface. SMARTT group authorship: Noriah Maraba1, Heeran Makkan1, Trevor Beattie1, Zandile Rachel Sibeko1, S’thabiso Bohlela1, Pulane Segwaba1, Emmanuel Ayodeji Ogunbayo2, Nomadlozi Mhlambi2, Felicia Wells3, Leen Rigouts4, Gary Maartens5, Francesca Conradie6, John Black7, Sam Potgieter8. 1Aurum Institute, Johannesburg, South Africa; 2Universitas Academic Laboratory, National Health Laboratory Service and Department of Medical Microbiology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; 3South African Medical Research Council Centre for Tuberculosis Research, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; 4Unit of Mycobacteriology, Dept of Biomedical Sciences, Belgium, Institute of Tropical medicine, Antwerp, 5Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa; 6Clinical HIV Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg; 7Department of Medicine, Livingstone Hospital, Port Elizabeth, South Africa; 8Department of Internal Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa Trial registration: ClinicalTrials.gov NCT05017324. Registered on August 23, 2021.

Published
2022

29. Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial

Author

Delany-Moretlwe, Sinead, primary, Hughes, James P, additional, Bock, Peter, additional, Ouma, Samuel Gurrion, additional, Hunidzarira, Portia, additional, Kalonji, Dishiki, additional, Kayange, Noel, additional, Makhema, Joseph, additional, Mandima, Patricia, additional, Mathew, Carrie, additional, Spooner, Elizabeth, additional, Mpendo, Juliet, additional, Mukwekwerere, Pamela, additional, Mgodi, Nyaradzo, additional, Ntege, Patricia Nahirya, additional, Nair, Gonasagrie, additional, Nakabiito, Clemensia, additional, Nuwagaba-Biribonwoha, Harriet, additional, Panchia, Ravindre, additional, Singh, Nishanta, additional, Siziba, Bekezela, additional, Farrior, Jennifer, additional, Rose, Scott, additional, Anderson, Peter L, additional, Eshleman, Susan H, additional, Marzinke, Mark A, additional, Hendrix, Craig W, additional, Beigel-Orme, Stephanie, additional, Hosek, Sybil, additional, Tolley, Elizabeth, additional, Sista, Nirupama, additional, Adeyeye, Adeola, additional, Rooney, James F, additional, Rinehart, Alex, additional, Spreen, William R, additional, Smith, Kimberly, additional, Hanscom, Brett, additional, Cohen, Myron S, additional, Hosseinipour, Mina C, additional, Asmelash, Aida, additional, Sehurutshi, Alice, additional, Baguma, Allan, additional, Marais, Anita, additional, Kawoozo, Barbarah, additional, Malinga, Bongiwe Prudence, additional, Mirembe, Brenda Gati, additional, Okech, Brenda, additional, Esterhuizen, Bryan, additional, Murombedzi, Caroline, additional, Gadama, Daphne, additional, Hwengwere, Eldinah, additional, Roos, Elizabeth, additional, Magada, Elizabeth S, additional, Shava, Emily, additional, Piwowar-Manning, Estelle, additional, Tahuringana, Eunice, additional, Muhlanga, Felix GS, additional, Conradie, Francesca, additional, Angira, Frank, additional, Nanyonjo, Gertrude, additional, Kistnasami, Girisha, additional, Mvula, Hazzie, additional, Naidoo, Ishana, additional, Horak, Jaco, additional, Jere, Jane, additional, Moodley, Jeeva, additional, Shin, Katie, additional, Nel, Kerry, additional, Bokoch, Kevin, additional, Birungi, Lilian, additional, Emel, Lynda, additional, Monametsi, Maletsatsi, additional, Sibanda, Marvelous, additional, Mutambanengwe, Mercy, additional, Chitukuta, Miria, additional, Matimbira, Moleen, additional, Bhondai-Mhuri, Muchaneta, additional, Sibisi, Ncamsile, additional, Morar, Neetha, additional, Mudzonga, Netsai, additional, Natureeba, Paul, additional, Richardson, Paul, additional, Musara, Petina, additional, Macdonald, Pippa, additional, Nkambule, Rejoice, additional, Mosime, Repelang, additional, White, Rhonda, additional, Berhanu, Ribka, additional, Ncube-Sihlongonyane, Ritha, additional, Sekabira, Rogers, additional, Siva, Samantha, additional, Pillay, Saresha, additional, Govender, Shamelle, additional, Bamweyana, Sheiala, additional, Nzimande, Siyabonga, additional, Innes, Steve, additional, Dadabhai, Sufia, additional, Samandari, Taraz, additional, Tembo, Tchangani, additional, Lungu Mabedi, Thandie, additional, Chirenda, Thandiwe, additional, Chidemo, Tinashe, additional, Mudhune, Victor, additional, Naidoo, Vikesh, additional, Samaneka, Wadzanai, additional, Agyei, Yaw, additional, Musodza, Yeukai, additional, Fourie, Yolandie, additional, and Gaffoor, Zakir, additional

Published
2022
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31. Building Capacity for the Assessment of HIV Drug Resistance: Experiences From the PharmAccess African Studies to Evaluate Resistance Network

Author

PharmAccess African Studies to Evaluate Resistance, Hamers, Raph L., Straatsma, Elske, Kityo, Cissy, Wallis, Carole L., Stevens, Wendy S., Sigaloff, Kim C. E., Siwale, Margaret, Conradie, Francesca, Botes, Mariette E., Mandaliya, Kishor, Wellington, Maureen, Osibogun, Akin, van Vugt, Michèle, and de Wit, Tobias F. Rinke

Published
2012
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32. Post COVID-19 Condition in South Africa: 3-month follow-up after hospitalisation with SARS-CoV-2

Author

Dryden, Murray, primary, Mudara, Caroline, additional, Vika, Caroline, additional, Blumberg, Lucille, additional, Mayet, Natalie, additional, Cohen, Cheryl, additional, Tempia, Stefano, additional, Parker, Arifa, additional, Nel, Jeremy, additional, Perumal, Rubeshan, additional, Groome, Michelle J., additional, Conradie, Francesca, additional, Ndjeka, Norbert, additional, Sigfrid, Louise, additional, Merson, Laura, additional, and Jassat, Waasila, additional

Published
2022
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33. Post COVID-19 Condition in South Africa: 3-Month Follow-Up after Hospitalisation with SARS-CoV-2

Author

Dryden, Murray Thomas Goble, primary, Mudara, Caroline, additional, Vika, Caroline, additional, Blumberg, Lucille, additional, Mayet, Natalie, additional, Cohen, Cheryl, additional, Tempia, Stefano, additional, Parker, Arifa, additional, Nel, Jeremy, additional, Perumal, Rubeshan, additional, Groome, Michelle, additional, Conradie, Francesca, additional, Ndjeka, Norbert, additional, Sigfrid, Louise, additional, Merson, Laura, additional, and Jassat, Waasila, additional

Published
2022
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34. Cabotegravir for Prevention of HIV-1 in Women: Results From HPTN 084, a Phase III, Randomised Controlled Trial

Author

Delany-Moretlwe, Sinead, primary, Hughes, James P., additional, Bock, Peter, additional, Ouma, Samuel Gurrion, additional, Hunidzarira, Portia, additional, Kalonji, Dishiki, additional, Kayange, Noel, additional, Makhema, Joseph, additional, Mandima, Patricia, additional, Mathew, Carrie, additional, Spooner, Elizabeth, additional, Mpendo, Juliet, additional, Mukwekwerere, Pamela, additional, Mgodi, Nyaradzo M., additional, Ntege, Patricia Nahirya, additional, Nair, Gonasagrie, additional, Nakabiito, Clemensia, additional, Nuwagaba-Biribonwoha, Harriet, additional, Panchia, Ravindre, additional, Singh, Nishanta, additional, Siziba, Bekezela, additional, Farrior, Jennifer, additional, Rose, Scott, additional, Berhanu, Rebecca, additional, Anderson, Peter L, additional, Agyei, Yaw, additional, Eshleman, Susan H., additional, Marzinke, Mark A., additional, Piwowar-Manning, Estelle, additional, Hendrix, Craig W., additional, Asmelash, Aida, additional, Conradie, Francesca, additional, Moorhouse, Michelle, additional, Richardson, Paul, additional, Beigel-Orme, Stephanie, additional, Emel, Lynda, additional, Bokoch, Kevin, additional, White, Rhonda, additional, Hosek, Sybil, additional, Tolley, Elizabeth, additional, Sista, Nirupama, additional, Shin, Katherine, additional, Adeyeye, Adeola, additional, Rooney, James, additional, Rinehart, Alex R., additional, Spreen, William R, additional, Smith, Kimberly, additional, Hanscom, Brett, additional, Cohen, Myron S., additional, and Hosseinipour, Mina C., additional

Published
2022
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36. HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study

Author

Hamers, Raph L, Wallis, Carole L, Kityo, Cissy, Siwale, Margaret, Mandaliya, Kishor, Conradie, Francesca, Botes, Mariette E, Wellington, Maureen, Osibogun, Akin, Sigaloff, Kim C E, Nankya, Immaculate, Schuurman, Rob, Wit, Ferdinand W, Stevens, Wendy S, van Vugt, Michèle, and de Wit, Tobias F Rinke

Published
2011
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37. Cost-effectiveness of bedaquiline, pretomanid and linezolid for treatment of extensively drug-resistant tuberculosis in South Africa, Georgia and the Philippines

Author

Gomez, Gabriela Beatriz, primary, Siapka, Mariana, additional, Conradie, Francesca, additional, Ndjeka, Norbert, additional, Garfin, Anna Marie Celina, additional, Lomtadze, Nino, additional, Avaliani, Zaza, additional, Kiria, Nana, additional, Malhotra, Shelly, additional, Cook-Scalise, Sarah, additional, Juneja, Sandeep, additional, Everitt, Daniel, additional, Spigelman, Melvin, additional, and Vassall, Anna, additional

Published
2021
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40. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial

Author

Sanne, Ian, Orrell, Catherine, Fox, Matthew P, Conradie, Francesca, Ive, Prudence, Zeinecker, Jennifer, Cornell, Morna, Heiberg, Christie, Ingram, Charlotte, Panchia, Ravindre, Rassool, Mohammed, Gonin, René, Stevens, Wendy, Truter, Handré, Dehlinger, Marjorie, van der Horst, Charles, McIntyre, James, and Wood, Robin

Published
2010
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41. QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial

Author

Dooley, Kelly E, primary, Rosenkranz, Susan L, additional, Conradie, Francesca, additional, Moran, Laura, additional, Hafner, Richard, additional, von Groote-Bidlingmaier, Florian, additional, Lama, Javier R., additional, Shenje, Justin, additional, De Los Rios, Jorge, additional, Comins, Kyla, additional, Morganroth, Joel, additional, Diacon, Andreas H, additional, Cramer, Yoninah S, additional, Donahue, Kathleen, additional, Maartens, Gary, additional, Alli, Oladapo, additional, Gottesman, Joan, additional, Guevara, Maria, additional, Hikuam, Chris, additional, Hovind, Laura, additional, Karlsson, Mats, additional, McClaren, Jennifer, additional, McIlleron, Helen, additional, Murtaugh, William, additional, Rolls, Barbara, additional, Shahkolahi, Akbar, additional, Stone, Lynnett, additional, Tegha, Gerald, additional, Tenai, Jacob, additional, Upton, Caryn, additional, and Wimbish, Chanelle, additional

Published
2021
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42. Treatment Outcomes 24 Months after Initiating Short Bedaquiline- or Injectable-Containing Rifampicin-Resistant Tuberculosis Treatment Regimens: A Retrospective Cohort Study in South Africa

Author

Ndjeka, Norbert, primary, Campbell, Jonathon, additional, Meintjes, Graeme, additional, Maartens, Gary, additional, Schaaf, H. Simon, additional, Hughes, J, additional, Padanilam, Xavier, additional, Reuter, Anja, additional, Romero, R, additional, Ismail, Farzana, additional, Enwerem, Martin, additional, Ferreira, Hannatjie, additional, Conradie, Francesca, additional, Naidoo, Kogieleum, additional, and Menzies, Dick, additional

Published
2021
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43. Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients

Author

Nel, Jeremy S., primary, Conradie, Francesca, additional, Botha, Jean, additional, Etheredge, Harriet, additional, Fabian, June, additional, Levin, Leon, additional, Mazanderani, Ahmad H., additional, Moorhouse, Michelle, additional, Muller, Elmi, additional, Tiemessen, Caroline, additional, Thomson, David, additional, and Turner, Julia, additional

Published
2020
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45. Cohort Profile: The PharmAccess African (PASER-M) and the TREAT Asia (TASER-M) Monitoring Studies to Evaluate Resistance—HIV drug resistance in sub-Saharan Africa and the Asia-Pacific

Author

Hamers, Raph L, Oyomopito, Rebecca, Kityo, Cissy, Phanuphak, Praphan, Siwale, Margaret, Sungkanuparph, Somnuek, Conradie, Francesca, Kumarasamy, Nagalingeswaran, Botes, Mariette E, Sirisanthana, Thira, Abdallah, Saade, Li, Patrick C K, Ngorima, Nicoletta, Kantipong, Pacharee, Osibogun, Akin, Lee, Christopher K C, Stevens, Wendy S, Kamarulzaman, Adeeba, Derdelinckx, Inge, Chen, Yi-Ming Arthur, Schuurman, Rob, van Vugt, Michèle, and Rinke de Wit, Tobias F

Published
2012
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47. Responding to SARS-CoV-2 in South Africa: what can we learn from drug-resistant tuberculosis?

Author

Ndjeka, Norbert, primary, Conradie, Francesca, additional, Meintjes, Graeme, additional, Reuter, Anja, additional, Hughes, Jennifer, additional, Padanilam, Xavier, additional, Ismail, Nazir, additional, Kock, Yulene, additional, Master, Iqbal, additional, Romero, Rodolfo, additional, te Riele, Julian, additional, Enwerem, Martin, additional, Ferreira, Hannetjie, additional, and Maartens, Gary, additional

Published
2020
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48. Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

Author

Conradie, Francesca, primary, Diacon, Andreas H., additional, Ngubane, Nosipho, additional, Howell, Pauline, additional, Everitt, Daniel, additional, Crook, Angela M., additional, Mendel, Carl M., additional, Egizi, Erica, additional, Moreira, Joanna, additional, Timm, Juliano, additional, McHugh, Timothy D., additional, Wills, Genevieve H., additional, Bateson, Anna, additional, Hunt, Robert, additional, Van Niekerk, Christo, additional, Li, Mengchun, additional, Olugbosi, Morounfolu, additional, and Spigelman, Melvin, additional

Published
2020
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49. A Partially-Randomised Phase 3 Trial of Pretomanid, Moxifloxacin and Pyrazinamide in Combination for the Treatment of Drug-Susceptible and Drug-Resistant Pulmonary Tuberculosis

Author

Tweed, Conor, primary, Wills, Genevieve H, additional, Crook, Angela M, additional, Amukoye, Evans, additional, Balanag, Vincent, additional, Ban, Andrea YL, additional, Bateson, Anna LC, additional, Betteridge, Matthew C, additional, Brumskine, William, additional, Caoili, Janice, additional, Chaisson, Richard E, additional, Cevik, Muge, additional, Conradie, Francesca, additional, Dawson, Rodney, additional, del Parigi, Angelo, additional, Diacon, Andreas, additional, Everitt, Daniel E, additional, Fabiane, Stella M, additional, Hunt, Robert, additional, Ahmad, Ismail, additional, Lalloo, Umesh, additional, Lombard, Leandra, additional, Louw, Cheryl, additional, Malahleha, Mookho, additional, McHugh, Timothy D, additional, Mendel, Carl M, additional, Mhimbira, Francis, additional, Moodliar, Ronellle N, additional, Nduba, Videlis, additional, Nunn, Andrew J, additional, Sabi, Issa, additional, Sebe, Modulakgotla A, additional, Selepe, Raesibe AP, additional, Staples, Suzanne, additional, Swindells, Susan, additional, van Niekerk, Christo H, additional, Variava, Ebrahim, additional, Spigelman, Mel, additional, and Gillespie, Stephen H, additional

Published
2020
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