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1. Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960–1999 and registered in the Italian Off-Therapy Registry

Author

Byrne, Julianne, Haupt, Riccardo, Pierani, Paolo, Santoro, Nicola, Pession, Andreea, Porta, Fulvio, Mura, Rossella, Russo, Giovanna, Consarino, Caterina, Burnelli, Roberta, Favre, Claudio, Garrè, Maria Luisa, Fedeli, Fausto, Massimino, Maura, Cellini, Monica, Biondi, Andrea, Casale, Fiorina, Menna, Giuseppe, Basso, Giuseppe, D'Angelo, Paolo, Bertolini, Patrizia, Zecca, Marco, Caniglia, Maurizio, Cecinati, Valerio, Casazza, Gabriella, Foà, Roberto, Clerico, Anna, Locatelli, Franco, Ladogana, Saverio, Galimberti, Daniela, Fagioli, Franca, Rabusin, Marco, Nespoli, Luigi, Cesaro, Simone, Bagnasco, Francesca, Caruso, Silvia, Andreano, Anita, Valsecchi, Maria Grazia, Jankovic, Momcilo, Miligi, Lucia, Casella, Claudia, Terenziani, Monica, Sacerdote, Carlotta, Morsellino, Vera, Erminio, Giovanni, Garaventa, Alberto, Faraci, Maura, Micalizzi, Concetta, Pillon, Marta, Biasin, Eleonora, Rondelli, Roberto, Pession, Andrea, Indolfi, Paolo, Palumbo, Giovanna, Verzegnassi, Federico, and Cano, Carmen

Published
2019
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2. The prognostic value of biological markers in paediatric Hodgkin lymphoma

Author

Cesaro, Simone, Zaccaron, Ada, Bertolini, Patrizia, Consarino, Caterina, Iaria, Grazia, Pericoli, Roberta, Pierani, Paolo, Fedeli, Fausto, Cellini, Monica, De Santis, Raffaela, Porta, Fulvio, Caini, Mauro, Cosmi, Carlo, Mirra, Nadia, Civino, Adele, Sperlì, Domenico, Nespoli, Luigi, Caniglia, Maurizio, Perruccio, Katia, D'Angelo, Paolo, Passone, Eva, Caruso, Roberta, Scarzello, Giovanni, Rondelli, Roberto, Farruggia, Piero, Puccio, Giuseppe, Sala, Alessandra, Todesco, Alessandra, Buffardi, Salvatore, Garaventa, Alberto, Bottigliero, Gaetano, Bianchi, Maurizio, Zecca, Marco, Locatelli, Franco, Pession, Andrea, Pillon, Marta, Favre, Claudio, D'Amico, Salvatore, Provenzi, Massimo, Trizzino, Angela, Zanazzo, Giulio Andrea, Sau, Antonella, Santoro, Nicola, Murgia, Giulio, Casini, Tommaso, Mascarin, Maurizio, and Burnelli, Roberta

Published
2016
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3. Human Fibrinogen Concentrate and Fresh Frozen Plasma in the Management of Severe Acquired Hypofibrinogenemia in Children With Acute Lymphoblastic Leukemia: Results of a Retrospective Survey

Author

Giordano, Paola, Grassi, Massimo, Saracco, Paola, Luciani, Matteo, Colombini, Antonella, Testi, Anna M., Micalizzi, Concetta, Petruzziello, Fara, Putti, Maria C., Casale, Fiorina, Consarino, Caterina, Mura, Rosa M., Mastrodicasa, Elena, Notarangelo, Lucia D., Onofrillo, Daniela, Pollio, Berardino, Rizzari, Carmelo, Tafuri, Silvio, De Leonardis, Francesco, Corallo, Paola C., and Santoro, Nicola

Published
2019
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4. Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Author

Parasole, Rosanna, Valsecchi, Maria G., Silvestri, Daniela, Locatelli, Franco, Barisone, Elena, Petruzziello, Fara, Putti, M. Caterina, Micalizzi, Concetta, Colombini, Antonella, Mura, Rossella, Mina, Tommaso, Testi, Anna M., Notarangelo, Lucia D., Santoro, Nicola, Casini, Tommaso, Consarino, Caterina, Nigro, Luca Lo, Ziino, Ottavio, Giagnuolo, Giovanna, Rizzari, Carmelo, and Conter, Valentino

Published
2018
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5. Early response does not predict outcome in children and adolescents with chronic myeloid leukaemia treated with high‐dose imatinib

Author

Giona, Fiorina, Saglio, Giuseppe, Santopietro, Michelina, Menna, Giuseppe, Putti, Maria Caterina, Micalizzi, Concetta, Iaria, Grazia, Santoro, Nicola, Ladogana, Saverio, Mura, Rosamaria, Burnelli, Roberta, Consarino, Caterina, Cosmi, Carlo, Moleti, Maria Luisa, Leszl, Anna, Tucci, Francesca, Nanni, Mauro, Diverio, Daniela, Biondi, Andrea, Locatelli, Franco, and Foà, Robin

Published
2018
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6. Long-term results of high-dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: the Italian experience

Author

Giona, Fiorina, Putti, Maria C., Micalizzi, Concetta, Menna, Giuseppe, Moleti, Maria L., Santoro, Nicola, Iaria, Grazia, Ladogana, Saverio, Burnelli, Roberta, Consarino, Caterina, Varotto, Stefania, Tucci, Francesca, Messina, Chiara, Nanni, Mauro, Diverio, Daniela, Biondi, Andrea, Pession, Andrea, Locatelli, Franco, Piciocchi, Alfonso, Gottardi, Enrico, Saglio, Giuseppe, and Foà, Robin

Published
2015
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7. Are all cases of paediatric essential thrombocythaemia really myeloproliferative neoplasms? Analysis of a large cohort

Author

Randi, Maria L., Geranio, Giulia, Bertozzi, Irene, Micalizzi, Concetta, Ramenghi, Ugo, Tucci, Fabio, Notarangelo, Lucia D., Ladogana, Saverio, Menna, Giuseppe, Giordano, Paola, Consarino, Caterina, Farruggia, Piero, Zanazzo, Giulio A., Fiori, Giovanni M., Burnelli, Roberta, Russo, Giovanna, Jankovich, Momcilo, Peroni, Edoardo, Duner, Elena, Basso, Giuseppe, Fabris, Fabrizio, and Putti, Maria C.

Published
2015
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8. First evidence of a paediatric patient with Cornelia de Lange syndrome with acute lymphoblastic leukaemia

Author

Fazio, Grazia, primary, Massa, Valentina, additional, Grioni, Andrea, additional, Bystry, Vojtech, additional, Rigamonti, Silvia, additional, Saitta, Claudia, additional, Galbiati, Marta, additional, Rizzari, Carmelo, additional, Consarino, Caterina, additional, Biondi, Andrea, additional, Selicorni, Angelo, additional, and Cazzaniga, Giovanni, additional

Published
2019
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9. Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960–1999 and registered in the Italian Off-Therapy Registry

Author

Bagnasco, F, Caruso, S, Andreano, A, Valsecchi, M, Jankovic, M, Biondi, A, Miligi, L, Casella, C, Terenziani, M, Massimino, M, Sacerdote, C, Morsellino, V, Erminio, G, Garaventa, A, Faraci, M, Micalizzi, C, Garrè, M, Pillon, M, Basso, G, Biasin, E, Fagioli, F, Rondelli, R, Pession, A, Locatelli, F, Santoro, N, Indolfi, P, Palumbo, G, Russo, G, Verzegnassi, F, Favre, C, Zecca, M, Mura, R, D'Angelo, P, Cano, C, Byrne, J, Haupt, R, Pierani, P, Porta, F, Consarino, C, Burnelli, R, Fedeli, F, Cellini, M, Casale, F, Menna, G, Bertolini, P, Caniglia, M, Cecinati, V, Casazza, G, Foà, R, Clerico, A, Ladogana, S, Galimberti, D, Rabusin, M, Nespoli, L, Cesaro, S, Bagnasco, Francesca, Caruso, Silvia, Andreano, Anita, Valsecchi, Maria Grazia, Jankovic, Momcilo, Biondi, Andrea, Miligi, Lucia, Casella, Claudia, Terenziani, Monica, Massimino, Maura, Sacerdote, Carlotta, Morsellino, Vera, Erminio, Giovanni, Garaventa, Alberto, Faraci, Maura, Micalizzi, Concetta, Garrè, Maria Luisa, Pillon, Marta, Basso, Giuseppe, Biasin, Eleonora, Fagioli, Franca, Rondelli, Roberto, Pession, Andrea, Locatelli, Franco, Santoro, Nicola, Indolfi, Paolo, Palumbo, Giovanna, Russo, Giovanna, Verzegnassi, Federico, Favre, Claudio, Zecca, Marco, Mura, Rossella, D'Angelo, Paolo, Cano, Carmen, Byrne, Julianne, Haupt, Riccardo, Pierani, Paolo, Pession, Andreea, Porta, Fulvio, Consarino, Caterina, Burnelli, Roberta, Fedeli, Fausto, Cellini, Monica, Casale, Fiorina, Menna, Giuseppe, Bertolini, Patrizia, Caniglia, Maurizio, Cecinati, Valerio, Casazza, Gabriella, Foà, Roberto, Clerico, Anna, Ladogana, Saverio, Galimberti, Daniela, Rabusin, Marco, Nespoli, Luigi, Cesaro, Simone, Bagnasco, F, Caruso, S, Andreano, A, Valsecchi, M, Jankovic, M, Biondi, A, Miligi, L, Casella, C, Terenziani, M, Massimino, M, Sacerdote, C, Morsellino, V, Erminio, G, Garaventa, A, Faraci, M, Micalizzi, C, Garrè, M, Pillon, M, Basso, G, Biasin, E, Fagioli, F, Rondelli, R, Pession, A, Locatelli, F, Santoro, N, Indolfi, P, Palumbo, G, Russo, G, Verzegnassi, F, Favre, C, Zecca, M, Mura, R, D'Angelo, P, Cano, C, Byrne, J, Haupt, R, Pierani, P, Porta, F, Consarino, C, Burnelli, R, Fedeli, F, Cellini, M, Casale, F, Menna, G, Bertolini, P, Caniglia, M, Cecinati, V, Casazza, G, Foà, R, Clerico, A, Ladogana, S, Galimberti, D, Rabusin, M, Nespoli, L, Cesaro, S, Bagnasco, Francesca, Caruso, Silvia, Andreano, Anita, Valsecchi, Maria Grazia, Jankovic, Momcilo, Biondi, Andrea, Miligi, Lucia, Casella, Claudia, Terenziani, Monica, Massimino, Maura, Sacerdote, Carlotta, Morsellino, Vera, Erminio, Giovanni, Garaventa, Alberto, Faraci, Maura, Micalizzi, Concetta, Garrè, Maria Luisa, Pillon, Marta, Basso, Giuseppe, Biasin, Eleonora, Fagioli, Franca, Rondelli, Roberto, Pession, Andrea, Locatelli, Franco, Santoro, Nicola, Indolfi, Paolo, Palumbo, Giovanna, Russo, Giovanna, Verzegnassi, Federico, Favre, Claudio, Zecca, Marco, Mura, Rossella, D'Angelo, Paolo, Cano, Carmen, Byrne, Julianne, Haupt, Riccardo, Pierani, Paolo, Pession, Andreea, Porta, Fulvio, Consarino, Caterina, Burnelli, Roberta, Fedeli, Fausto, Cellini, Monica, Casale, Fiorina, Menna, Giuseppe, Bertolini, Patrizia, Caniglia, Maurizio, Cecinati, Valerio, Casazza, Gabriella, Foà, Roberto, Clerico, Anna, Ladogana, Saverio, Galimberti, Daniela, Rabusin, Marco, Nespoli, Luigi, and Cesaro, Simone

Abstract

Introduction: Advances in paediatric oncology led to the increase in long-term survival, revealing the burden of therapy-related long-term side effects. We evaluated overall and cause-specific mortality in a large cohort of Italian childhood cancer survivors (CCSs) and adolescent cancer survivors identified through the off-therapy registry. Materials and methods: CCSs alive 5 years after cancer diagnosis occurring between 1960 and 1999 were eligible; the last follow-up was between 2011 and 2014. Outcomes were reported as standardised mortality ratios (SMRs) and absolute excess risks (AERs). Results: Among 12,214 CCSs, 1113 (9.1%) deaths occurred. Survival at 35 years since diagnosis was 87% (95% confidence interval [CI]: 86–88) and at 45 years was 81% (95% CI: 77–84). CCSs had an 11-fold increased risk of death (SMR 95% CI: 10.7–12), corresponding to an AER of 48 (95% CI: 45–51). Mortality decreased by 60% for survivors treated most recently (1990–1999). The most frequent causes of death were recurrence of the original cancer (56%), a subsequent neoplasm (19%) and cardiovascular diseases (5.8%). Among those who survived at least 15 years after diagnosis, a secondary malignancy was the leading cause of death. Conclusions: This study confirms the impact of recent advances in anticancer therapy in reducing mortality, mainly attributable to recurrence but also to other causes. However, overall mortality continues to be higher than in the general population. A long-term follow-up is needed to prevent late mortality due to secondary neoplasms and non-neoplastic causes in CCSs.

Published
2019

10. First evidence of a paediatric patient with Cornelia de Lange syndrome with acute lymphoblastic leukaemia

Author

Fazio, G, Massa, V, Grioni, A, Bystry, V, Rigamonti, S, Saitta, C, Galbiati, M, Rizzari, C, Consarino, C, Biondi, A, Selicorni, A, Cazzaniga, G, Fazio, Grazia, Massa, Valentina, GRIONI, ANDREA, Bystry, Vojtech, Rigamonti, Silvia, Saitta, Claudia, Galbiati, Marta, Rizzari, Carmelo, Consarino, Caterina, Biondi, Andrea, Selicorni, Angelo, Cazzaniga, Giovanni, Fazio, G, Massa, V, Grioni, A, Bystry, V, Rigamonti, S, Saitta, C, Galbiati, M, Rizzari, C, Consarino, C, Biondi, A, Selicorni, A, Cazzaniga, G, Fazio, Grazia, Massa, Valentina, GRIONI, ANDREA, Bystry, Vojtech, Rigamonti, Silvia, Saitta, Claudia, Galbiati, Marta, Rizzari, Carmelo, Consarino, Caterina, Biondi, Andrea, Selicorni, Angelo, and Cazzaniga, Giovanni

Abstract

Cornelia de Lange syndrome (CdLS) is a rare autosomal-dominant genetic disorder characterised by prenatal and postnatal growth and mental retardation, facial dysmorphism and upper limb abnormalities. Germline mutations of cohesin complex genes SMC1A, SMC3, RAD21 or their regulators NIPBL and HDAC8 have been identified in CdLS as well as somatic mutations in myeloid disorders. We describe the first case of a paediatric patient with CdLS with B-cell precursor Acute Lymphoblastic Leukaemia (ALL). The patient did not show any unusual cytogenetic abnormality, and he was enrolled into the high risk arm of AIEOP-BFM ALL2009 protocol because of slow early response, but 3 years after discontinuation, he experienced an ALL relapse. We identified a heterozygous mutation in exon 46 of NIPBL, causing frameshift and a premature stop codon (RNA-Targeted Next generation Sequencing Analysis). The analysis of the family indicated a de novo origin of this previously not reported deleterious variant. As for somatic cohesin mutations in acute myeloid leukaemia, also this ALL case was not affected by aneuploidy, thus suggesting a major impact of the non-canonical role of NIPBL in gene regulation. A potential biological role of NIPBL in leukaemia has still to be dissected.

Published
2019

11. Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960–1999 and registered in the Italian Off-Therapy Registry

Author

Bagnasco, Francesca, primary, Caruso, Silvia, additional, Andreano, Anita, additional, Valsecchi, Maria Grazia, additional, Jankovic, Momcilo, additional, Biondi, Andrea, additional, Miligi, Lucia, additional, Casella, Claudia, additional, Terenziani, Monica, additional, Massimino, Maura, additional, Sacerdote, Carlotta, additional, Morsellino, Vera, additional, Erminio, Giovanni, additional, Garaventa, Alberto, additional, Faraci, Maura, additional, Micalizzi, Concetta, additional, Garrè, Maria Luisa, additional, Pillon, Marta, additional, Basso, Giuseppe, additional, Biasin, Eleonora, additional, Fagioli, Franca, additional, Rondelli, Roberto, additional, Pession, Andrea, additional, Locatelli, Franco, additional, Santoro, Nicola, additional, Indolfi, Paolo, additional, Palumbo, Giovanna, additional, Russo, Giovanna, additional, Verzegnassi, Federico, additional, Favre, Claudio, additional, Zecca, Marco, additional, Mura, Rossella, additional, D'Angelo, Paolo, additional, Cano, Carmen, additional, Byrne, Julianne, additional, Haupt, Riccardo, additional, Pierani, Paolo, additional, Pession, Andreea, additional, Porta, Fulvio, additional, Consarino, Caterina, additional, Burnelli, Roberta, additional, Fedeli, Fausto, additional, Cellini, Monica, additional, Casale, Fiorina, additional, Menna, Giuseppe, additional, Bertolini, Patrizia, additional, Caniglia, Maurizio, additional, Cecinati, Valerio, additional, Casazza, Gabriella, additional, Foà, Roberto, additional, Clerico, Anna, additional, Ladogana, Saverio, additional, Galimberti, Daniela, additional, Rabusin, Marco, additional, Nespoli, Luigi, additional, and Cesaro, Simone, additional

Published
2019
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12. Real-Life Management of Children and Adolescents with Chronic Myeloid Leukemia: The Italian Experience

Author

Giona, F, Santopietro, M, Menna, G, Putti, M, Micalizzi, C, Santoro, N, Ziino, O, Mura, R, Ladogana, S, Iaria, G, Sau, A, Burnelli, R, Vacca, N, Bernasconi, S, Consarino, C, Petruzziello, F, Moleti, M, Biondi, A, Locatelli, F, Foà, R, Giona, Fiorina, Santopietro, Michelina, Menna, Giuseppe, Putti, Maria Caterina, Micalizzi, Concetta, Santoro, Nicola, Ziino, Ottavio, Mura, Rosamaria, Ladogana, Saverio, Iaria, Grazia, Sau, Antonella, Burnelli, Roberta, Vacca, Nadia, Bernasconi, Sayla, Consarino, Caterina, Petruzziello, Fara, Moleti, Maria Luisa, Biondi, Andrea, Locatelli, Franco, Foà, Robin, Giona, F, Santopietro, M, Menna, G, Putti, M, Micalizzi, C, Santoro, N, Ziino, O, Mura, R, Ladogana, S, Iaria, G, Sau, A, Burnelli, R, Vacca, N, Bernasconi, S, Consarino, C, Petruzziello, F, Moleti, M, Biondi, A, Locatelli, F, Foà, R, Giona, Fiorina, Santopietro, Michelina, Menna, Giuseppe, Putti, Maria Caterina, Micalizzi, Concetta, Santoro, Nicola, Ziino, Ottavio, Mura, Rosamaria, Ladogana, Saverio, Iaria, Grazia, Sau, Antonella, Burnelli, Roberta, Vacca, Nadia, Bernasconi, Sayla, Consarino, Caterina, Petruzziello, Fara, Moleti, Maria Luisa, Biondi, Andrea, Locatelli, Franco, and Foà, Robin

Abstract

Background: To date, no data on the adherence to specific guidelines for children with chronic myeloid leukemia (CML) in chronic phase (CP) have been reported. Methods: Since 2001, guidelines for treatment with imatinib mesylate (IM) and monitoring in patients younger than 18 years with CP-CML have been shared with 9 pediatric referral centers (P centers) and 4 reference centers for adults and children/adolescents (AP centers) in Italy. In this study, the adherence to these guidelines was analyzed. Results: Thirty-four patients with a median age of 11.4 years and 23 patients with a median age of 11.0 years were managed at 9 P and at 4 AP centers, respectively. Evaluations of bone marrow (BM) and/or peripheral blood (PB) were available for more than 90% of evaluable patients. Cytogenetics and molecular monitoring of PB were more consistently performed in AP centers, whereas molecular analysis of BM was carried out more frequently in P centers. Before 2009, some patients who responded to IM underwent a transplantation, contrary to the guidelines' recommendations. Conclusions: Our experience shows that having specific guidelines is an important tool for an optimal management of childhood CP-CML, together with exchange of knowledge and proactive discussions within the network

Published
2018

13. Real-Life Management of Children and Adolescents with Chronic Myeloid Leukemia: The Italian Experience

Author

Giona, Fiorina, primary, Santopietro, Michelina, additional, Menna, Giuseppe, additional, Putti, Maria Caterina, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Ziino, Ottavio, additional, Mura, Rosamaria, additional, Ladogana, Saverio, additional, Iaria, Grazia, additional, Sau, Antonella, additional, Burnelli, Roberta, additional, Vacca, Nadia, additional, Bernasconi, Sayla, additional, Consarino, Caterina, additional, Petruzziello, Fara, additional, Moleti, Maria Luisa, additional, Biondi, Andrea, additional, Locatelli, Franco, additional, and Foà, Robin, additional

Published
2018
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14. Early response does not predict outcome in children and adolescents with chronic myeloid leukaemia treated with high-dose imatinib

Author

Giona, Fiorina, primary, Saglio, Giuseppe, additional, Santopietro, Michelina, additional, Menna, Giuseppe, additional, Putti, Maria Caterina, additional, Micalizzi, Concetta, additional, Iaria, Grazia, additional, Santoro, Nicola, additional, Ladogana, Saverio, additional, Mura, Rosamaria, additional, Burnelli, Roberta, additional, Consarino, Caterina, additional, Cosmi, Carlo, additional, Moleti, Maria Luisa, additional, Leszl, Anna, additional, Tucci, Francesca, additional, Nanni, Mauro, additional, Diverio, Daniela, additional, Biondi, Andrea, additional, Locatelli, Franco, additional, and Foà, Robin, additional

Published
2016
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15. Management of Chronic Myeloid Leukemia in Children and Adolescents According to Local Guidelines.the Italian Experience

Author

Giona, Fiorina, primary, Santopietro, Michelina, additional, Menna, Giuseppe, additional, Putti, Maria Caterina, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Ziino, Ottavio, additional, Mura, Rosamaria, additional, Ladogana, Saverio, additional, Iaria, Grazia, additional, Sau, Antonella, additional, Burnelli, Roberta, additional, Vacca, Nadia, additional, Nardi, Margherita, additional, Consarino, Caterina, additional, Moleti, Maria Luisa, additional, Nanni, Mauro, additional, Diverio, Daniela, additional, Leszl, Anna, additional, Biondi, Andrea, additional, Locatelli, Franco, additional, Saglio, Giuseppe, additional, and Foà, Robin, additional

Published
2016
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16. Abdomen/pelvis computed tomography in staging of pediatric Hodgkin Lymphoma: is it always necessary?

Author

Farruggia, Piero, primary, Puccio, Giuseppe, additional, Sala, Alessandra, additional, Todesco, Alessandra, additional, Terenziani, Monica, additional, Mura, Rosamaria, additional, D'Amico, Salvatore, additional, Casini, Tommaso, additional, Mosa, Clara, additional, Pillon, Marta, additional, Boaro, Maria Paola, additional, Bottigliero, Gaetano, additional, Burnelli, Roberta, additional, Consarino, Caterina, additional, Fedeli, Fausto, additional, Mascarin, Maurizio, additional, Perruccio, Katia, additional, Schiavello, Elisabetta, additional, Trizzino, Angela, additional, Ficola, Umberto, additional, Garaventa, Alberto, additional, and Rossello, Mario, additional

Published
2016
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17. The prognostic value of biological markers in paediatric Hodgkin lymphoma

Author

Farruggia, Piero, primary, Puccio, Giuseppe, additional, Sala, Alessandra, additional, Todesco, Alessandra, additional, Buffardi, Salvatore, additional, Garaventa, Alberto, additional, Bottigliero, Gaetano, additional, Bianchi, Maurizio, additional, Zecca, Marco, additional, Locatelli, Franco, additional, Pession, Andrea, additional, Pillon, Marta, additional, Favre, Claudio, additional, D'Amico, Salvatore, additional, Provenzi, Massimo, additional, Trizzino, Angela, additional, Zanazzo, Giulio Andrea, additional, Sau, Antonella, additional, Santoro, Nicola, additional, Murgia, Giulio, additional, Casini, Tommaso, additional, Mascarin, Maurizio, additional, Burnelli, Roberta, additional, Cesaro, Simone, additional, Zaccaron, Ada, additional, Bertolini, Patrizia, additional, Consarino, Caterina, additional, Iaria, Grazia, additional, Pericoli, Roberta, additional, Pierani, Paolo, additional, Fedeli, Fausto, additional, Cellini, Monica, additional, De Santis, Raffaela, additional, Porta, Fulvio, additional, Caini, Mauro, additional, Cosmi, Carlo, additional, Mirra, Nadia, additional, Civino, Adele, additional, Sperlì, Domenico, additional, Nespoli, Luigi, additional, Caniglia, Maurizio, additional, Perruccio, Katia, additional, D'Angelo, Paolo, additional, Passone, Eva, additional, Caruso, Roberta, additional, Scarzello, Giovanni, additional, and Rondelli, Roberto, additional

Published
2016
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18. Early Response Does Not Impact on the Long-Term Outcome of Children and Adolescents with Chronic Myeloid Leukemia Treated with High-Dose Imatinib. the Italian Experience

Author

Giona, Fiorina, primary, Saglio, Giuseppe, additional, Santopietro, Michelina, additional, Menna, Giuseppe, additional, Iaria, Grazia, additional, Putti, Maria Caterina, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Ladogana, Saverio, additional, Mura, Rosa Maria, additional, Burnelli, Roberta, additional, Consarino, Caterina, additional, Cosmi, Carlo, additional, Moleti, Maria Luisa, additional, Varotto, Stefania, additional, Tucci, Francesca, additional, Nanni, Mauro, additional, Diverio, Daniela, additional, Biondi, Andrea, additional, Locatelli, Franco, additional, and Foà, Robin, additional

Published
2015
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19. Long-Term Outcome in Children and Adolescents with Chronic Myeloid Leukemia in Chronic Phase Treated with High-Dose Imatinib— the Italian Experience

Author

Giona, Fiorina, Santopietro, Michelina, Menna, Giuseppe, Micalizzi, Concetta, Putti, Maria Caterina, Santoro, Nicola, Ziino, Ottavio, Mura, Rosamaria, Ladogana, Saverio, Iaria, Grazia, Sau, Antonella, Burnelli, Roberta, Vacca, Nadia, Nardi, Margherita, Consarino, Caterina, Miulli, Eleonora, Moleti, Maria Luisa, Petruzziello, Fara, Orlando, Sonia Maria, Biondi, Andrea, Locatelli, Franco, Saglio, Giuseppe, and Foa, Robin

Published
2017
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20. Response to High Dose Imatinib and Long-Term Outcome in Children and Adolescents with Previously Untreated Chronic Myeloid Leukemia in Chronic Phase. the Italian Experience

Author

Giona, Fiorina, primary, Putti, Maria Caterina, additional, Menna, Giuseppe, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Iaria, Grazia, additional, Ladogana, Saverio, additional, Burnelli, Roberta, additional, Consarino, Caterina, additional, Moleti, Maria Luisa, additional, Mariani, Sabrina, additional, De Benedittis, Daniela, additional, Marzella, Deborah, additional, Varotto, Stefania, additional, Tucci, Francesca, additional, Nanni, Mauro, additional, Messina, Chiara, additional, Diverio, Daniela, additional, Biondi, Andrea, additional, Pession, Andrea, additional, Zecca, Marco, additional, Locatelli, Franco, additional, Saglio, Giuseppe, additional, and Foà, Robin, additional

Published
2014
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21. High Dose Imatinib Is Effective In Children and Adolescents With Chronic Myelogenous Leukemia In Chronic Phase. The Italian Experience

Author

Giona, Fiorina, primary, Putti, Maria Caterina, additional, Menna, Giuseppe, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Iaria, Grazia, additional, Ladogana, Saverio, additional, Burnelli, Roberta, additional, Consarino, Caterina, additional, Siniscalchi, Benedetta, additional, Rea, Massimiliano, additional, Marzella, Deborah, additional, Tucci, Francesca, additional, Nanni, Mauro, additional, Messina, Chiara, additional, Varotto, Stefania, additional, Diverio, Daniela, additional, Biondi, Andrea, additional, Pession, Andrea, additional, Zecca, Marco, additional, Locatelli, Franco, additional, Saglio, Giuseppe, additional, and Foa', Robin, additional

Published
2013
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22. Retrospective Evaluation of 90 Children with Essential Thrombocytemia: The AIEOP Experience

Author

Putti, Maria Caterina, primary, Giona, Fiorina, additional, Consarino, Caterina, additional, Fiori, Gian Mario, additional, Giordano, Paola, additional, Ladogana, Saverio, additional, Jankovic, Momcilo, additional, Micalizzi, Concetta, additional, Pession, Andrea, additional, Pierani, Paolo, additional, Ramenghi, Ugo, additional, Scapin, Margherita, additional, Teofili, Luciana, additional, Tucci, Fabio, additional, Tettoni, Katia, additional, Zanazzo, Andrea Giulio, additional, and Randi, Maria Luigia, additional

Published
2008
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24. Spectrum of β‐thalassemia mutations in Calabria: Implications for prenatal diagnosis

Author

Magro, Saverio, primary, Santilli, Emanuele, additional, Mancuso, Rita, additional, Puzzonia, Pasquale, additional, Consarino, Caterina, additional, Morgione, Sergio, additional, Galati, Maria Concetta, additional, Fersini, Giuseppina, additional, Madonna, Giovanna, additional, Brancati, Carmela, additional, Vadalà, Pasquale, additional, and Molica, Stefano, additional

Published
1995
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26. Long-term results of high-dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: The Italian experience

Author

Chiara Messina, Stefania Varotto, Mauro Nanni, Francesca Tucci, Concetta Micalizzi, Grazia Iaria, Daniela Diverio, Giuseppe Saglio, Nicola Santoro, Fiorina Giona, Maria Luisa Moleti, Robin Foà, Enrico Gottardi, Andrea Pession, Maria C. Putti, Alfonso Piciocchi, Andrea Biondi, Saverio Ladogana, Franco Locatelli, Giuseppe Menna, Roberta Burnelli, Caterina Consarino, Giona, Fiorina, Putti, Maria C., Micalizzi, Concetta, Menna, Giuseppe, Moleti, Maria L., Santoro, Nicola, Iaria, Grazia, Ladogana, Saverio, Burnelli, Roberta, Consarino, Caterina, Varotto, Stefania, Tucci, Francesca, Messina, Chiara, Nanni, Mauro, Diverio, Daniela, Biondi, Andrea, Pession, Andrea, Locatelli, Franco, Piciocchi, Alfonso, Gottardi, Enrico, Saglio, Giuseppe, Foà, Robin, Giona, F, Putti, M, Micalizzi, C, Menna, G, Moleti, M, Santoro, N, Iaria, G, Ladogana, S, Burnelli, R, Consarino, C, Varotto, S, Tucci, F, Messina, C, Nanni, M, Diverio, D, Biondi, A, Pession, A, Locatelli, F, Piciocchi, A, Gottardi, E, Saglio, G, and Foà, R

Subjects
Male, International scale, bcr-abl, Fusion Proteins, bcr-abl, Tyrosine kinase inhibitor, Piperazines, Antineoplastic Agent, hemic and lymphatic diseases, Chronic myeloid leukaemia, childhood, imatinib, BCR-ABL1, tyrosine kinase inhibitors, Chronic, Child, Hematology, Leukemia, Survival Rate, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Child, Preschool, Benzamides, Imatinib Mesylate, Female, medicine.drug, Human, medicine.medical_specialty, Adolescent, Antineoplastic Agents, Chronic myeloid leukaemia, Disease-Free Survival, Follow-Up Studie, Benzamide, Internal medicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Preschool, Survival rate, Piperazine, Tyrosine kinase inhibitors, business.industry, Fusion Proteins, Imatinib, Long term results, BCR-ABL1, Childhood, Follow-Up Studies, Pyrimidines, Stem Cell Transplantation, Surgery, Transplantation, Imatinib mesylate, Pyrimidine, BCR-ABL Positive, business, Myelogenous
Abstract

Imatinib mesylate (IM) is used for the management of childhood chronic myeloid leukaemia (CML). The most effective dosage of IM and its long-term efficacy in children are not well defined. The purpose of this multicentre study is to report on the long-term results of high-dose IM (340 mg/m2 /d) in CML patients in chronic phase (CP-CML) aged

Published
2015

27. Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group.

Author

D'Angiò M, Valsecchi MG, Testi AM, Conter V, Nunes V, Parasole R, Colombini A, Santoro N, Varotto S, Caniglia M, Silvestri D, Consarino C, Levati L, Magrin E, Locatelli F, Basso G, Foà R, Biondi A, and Cazzaniga G

Subjects
Adolescent, Basic Helix-Loop-Helix Transcription Factors genetics, Biomarkers, Tumor genetics, Child, Child, Preschool, Cohort Studies, Drug Resistance, Neoplasm, Female, Follow-Up Studies, Humans, Immunophenotyping, Infant, Intracellular Signaling Peptides and Proteins genetics, Male, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local genetics, Neoplasm Recurrence, Local mortality, Neoplasm Staging, Oncogene Proteins, Fusion genetics, Patient Outcome Assessment, Polymerase Chain Reaction, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma genetics, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma mortality, Prognosis, Proto-Oncogene Proteins genetics, Survival Rate, T-Cell Acute Lymphocytic Leukemia Protein 1, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Basic Helix-Loop-Helix Transcription Factors metabolism, Biomarkers, Tumor metabolism, Intracellular Signaling Peptides and Proteins metabolism, Neoplasm Recurrence, Local pathology, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma pathology, Proto-Oncogene Proteins metabolism
Published
2015
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