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5. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk

Author

Baldassarre, Mariella, Consoli, Agostino, Morganet, Sara, Zugaro, Antonella, Baroni, Marco Giorgio, Andreozzi, Francesco, Gatti, Adriano, De Riu, Stefano, Del Buono, Andrea, Aldigeri, Raffaella, Bonadonna, Riccardo, Cas, Alessandra Dei, Vazzana, Angela, Antonini, Monica, Moretti, Valentina, Volsi, Patrizia Li, Cesare, Miranda, Zanette, Giorgio, Carletti, Silvia, D'Angelo, Paola, Leto, Gaetano, Leonetti, Frida, D'Onofrio, Luca, Maddaloni, Ernesto, Buzzetti, Raffaella, Frontoni, Simona, Cavallo, Giselle, Morano, Susanna, Filardi, Tiziana, Capece, Umberto, Giaccari, Andrea, Bossi, Antonio C., Meregalli, Giancarla, Querci, Fabrizio, Gaglio, Alessia, Resi, Veronica, Orsi, Emanuela, Fazion, Stefano, Franzetti, Ivano G., Berra, Cesare, Manfrini, Silvia, Garrapa, Gabriella, Lucarelli, Giulio, Riccialdelli, Lara, Tortato, Elena, Zavattaro, Marco, Aimaretti, Gianluca, Cavalot, Franco, Beccuti, Guglielmo, Broglio, Fabio, Fattor, Bruno, Cazzetta, Giuliana, Lamacchia, Olga, Rauseo, Anna, De Cosmo, Salvatore, Cau, Rosella, Ghiani, Mariangela, Di Benedetto, Antonino, Di Pino, Antonino, Piro, Salvatore, Purrello, Francesco, Frittitta, Lucia, Milluzzo, Agostino, Russo, Giuseppina, Fadini, Gian Paolo, Longato, Enrico, Morieri, Mario Luca, Del Prato, Stefano, Avogaro, Angelo, and Solini, Anna

Published
2024
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8. LDL-cholesterol control in the primary prevention of cardiovascular diseases: An expert opinion for clinicians and health professionals

Author

Poli, Andrea, Catapano, Alberico L., Corsini, Alberto, Manzato, Enzo, Werba, José Pablo, Catena, Gabriele, Cetin, Irene, Cicero, Arrigo F.G., Cignarella, Andrea, Colivicchi, Furio, Consoli, Agostino, Landi, Francesco, Lucarelli, Maurizio, Manfellotto, Dario, Marrocco, Walter, Parretti, Damiano, Perrone Filardi, Pasquale, Pirillo, Angela, Sesti, Giorgio, Volpe, Massimo, and Marangoni, Franca

Published
2023
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10. Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss

Author

Simeone, Paola, Tripaldi, Romina, Michelsen, Annika, Ueland, Thor, Liani, Rossella, Ciotti, Sonia, Birkeland, Kåre I., Gulseth, Hanne L., Di Castelnuovo, Augusto, Cipollone, Francesco, Aukrust, Pål, Consoli, Agostino, Halvorsen, Bente, and Santilli, Francesca

Published
2022
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13. Oral Semaglutide in Routine Clinical Practice: Characteristics of People with Type 2 Diabetes Started on the Drug and Changes in Their Clinical Parameters after 24 Weeks of Treatment

Author

Baldassarre, Maria Pompea Antonia, primary, Di Dalmazi, Giulia, additional, Coluzzi, Sara, additional, Carrieri, Federica, additional, Febo, Fabrizio, additional, Centorame, Giorgia, additional, Cassino, Piergiuseppe, additional, Piacentino, Luigi, additional, Baroni, Marco Giorgio, additional, Consoli, Agostino, additional, and Formoso, Gloria, additional

Published
2024
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14. Comparing the effectiveness and cost-effectiveness of sulfonylureas and newer diabetes drugs as second-line therapy for patients with type 2 diabetes

Author

Franchi, Matteo, primary, Pellegrini, Giacomo, additional, Avogaro, Angelo, additional, Buzzetti, Giuliano, additional, Candido, Riccardo, additional, Cavaliere, Arturo, additional, Consoli, Agostino, additional, Marzona, Irene, additional, Mennini, Francesco Saverio, additional, Palcic, Stefano, additional, and Corrao, Giovanni, additional

Published
2024
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15. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk

Author

Fadini, Gian Paolo, primary, Longato, Enrico, additional, Morieri, Mario Luca, additional, Del Prato, Stefano, additional, Avogaro, Angelo, additional, Solini, Anna, additional, Baldassarre, Mariella, additional, Consoli, Agostino, additional, Morganet, Sara, additional, Zugaro, Antonella, additional, Baroni, Marco Giorgio, additional, Andreozzi, Francesco, additional, Gatti, Adriano, additional, De Riu, Stefano, additional, Del Buono, Andrea, additional, Aldigeri, Raffaella, additional, Bonadonna, Riccardo, additional, Cas, Alessandra Dei, additional, Vazzana, Angela, additional, Antonini, Monica, additional, Moretti, Valentina, additional, Volsi, Patrizia Li, additional, Cesare, Miranda, additional, Zanette, Giorgio, additional, Carletti, Silvia, additional, D'Angelo, Paola, additional, Leto, Gaetano, additional, Leonetti, Frida, additional, D'Onofrio, Luca, additional, Maddaloni, Ernesto, additional, Buzzetti, Raffaella, additional, Frontoni, Simona, additional, Cavallo, Giselle, additional, Morano, Susanna, additional, Filardi, Tiziana, additional, Capece, Umberto, additional, Giaccari, Andrea, additional, Bossi, Antonio C., additional, Meregalli, Giancarla, additional, Querci, Fabrizio, additional, Gaglio, Alessia, additional, Resi, Veronica, additional, Orsi, Emanuela, additional, Fazion, Stefano, additional, Franzetti, Ivano G., additional, Berra, Cesare, additional, Manfrini, Silvia, additional, Garrapa, Gabriella, additional, Lucarelli, Giulio, additional, Riccialdelli, Lara, additional, Tortato, Elena, additional, Zavattaro, Marco, additional, Aimaretti, Gianluca, additional, Cavalot, Franco, additional, Beccuti, Guglielmo, additional, Broglio, Fabio, additional, Fattor, Bruno, additional, Cazzetta, Giuliana, additional, Lamacchia, Olga, additional, Rauseo, Anna, additional, De Cosmo, Salvatore, additional, Cau, Rosella, additional, Ghiani, Mariangela, additional, Di Benedetto, Antonino, additional, Di Pino, Antonino, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, Frittitta, Lucia, additional, Milluzzo, Agostino, additional, and Russo, Giuseppina, additional

Published
2024
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17. Oral or injectable semaglutide for the management of type 2 diabetes in routine care: A multicentre observational study comparing matched cohorts.

Author

Fadini, Gian Paolo, Bonora, Benedetta Maria, Ghiani, Mariangela, Anichini, Roberto, Melchionda, Elena, Fattor, Bruno, Fazion, Stefano, Meregalli, Giancarla, Giaccari, Andrea, Avogaro, Angelo, Consoli, Agostino, Baldassarre, Maria Antonia Pompea, Formoso, Gloria, Leto, Gaetano, Leonetti, Frida, Zavattaro, Marco, Aimaretti, Gianluca, Barale, Cristina, Cau, Rosella, and Muscarà, Andrea

Subjects
TYPE 2 diabetes, SEMAGLUTIDE, GLUCAGON-like peptide-1 receptor, GLUCAGON-like peptide-1 agonists, BODY mass index
Abstract

Aim: To investigate the real‐world utilization and comparative clinical outcomes of injectable and oral semaglutide in individuals with type 2 diabetes (T2D) with the aim of enhancing understanding of the practical implications associated with choosing between these formulations. Methods: New users of oral or injectable semaglutide were selected from a cohort of 14 079 initiators of glucagon‐like peptide‐1 receptor agonists. Propensity‐score matching (PSM) was employed to create balanced groups, ensuring comparability. The analysis encompassed dose exposure, drug persistence, and clinical outcomes, including changes in glycated haemoglobin (HbA1c) and body weight, with up to 18 months' follow‐up. Results: We analysed two matched groups of 107 participants each, who comprised on average 63.6% men, aged 64 years, with diabetes duration of approximately 10 years, body mass index of 29 kg/m2 and HbA1c level of 7.7–7.8% (61‐62 mmol/mol). The proportion of low, intermediate and high doses were similar with the oral and the injectable formulation. The change in HbA1c was similar between groups (−0.9% / ‐10 mmol/mol at 18 months) as was the proportion of individuals reaching HbA1c <6.5% (48 mmol/mol). The average change in body weight was similar in the two groups (−3.7 kg with injectable and −3.3 kg with oral at 18 months) but more new users of injectable semaglutide lost ≥5% body weight. Persistence on drug was longer with injectable than with oral semaglutide. Conclusion: In a real‐world setting, improvements in HbA1c and body weight were similar after initiation of oral or injectable semaglutide. These results may be specific to the features of the matched cohorts under investigation, with limited generalizability to populations with different characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Insulin Treatment

Author

Consoli, Agostino, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Bonora, Enzo, editor, and DeFronzo, Ralph A., editor

Published
2018
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22. IDegLira for the real‐world treatment of type 2 diabetes in Italy. Final results from the REX observational study.

Author

Fadini, Gian Paolo, Buzzetti, Raffaella, Pitocco, Dario, Tortato, Elena, Scatena, Alessia, Lamacchia, Olga, Lastoria, Giusi, Simoni, Lucia, and Consoli, Agostino

Subjects
TYPE 2 diabetes, INSULIN aspart, INSULIN, GLYCEMIC control, INSULIN therapy, HYPERGLYCEMIA, SCIENTIFIC observation, BLOOD sugar
Abstract

Aim: The study was designed to generate real‐world evidence on IDegLira in the Italian clinical practice in two groups of patients with type 2 diabetes (T2D), switching to IDegLira either from a basal only (basal group) or basal‐bolus insulin regimen (BB group). Materials and Methods: This was a non‐interventional, multicentre, single‐cohort, prospective study assessing the long‐term glycaemic control in patients with T2D, who switched to IDegLira from a basal insulin ± glucose‐lowering medication regimen with or without a bolus insulin component for approximately 18 months, conducted in 28 Italian diabetes centres. The primary endpoint was the change in glycated haemoglobin (HbA1c) levels from baseline to 6 months after IDegLira initiation. Results: The study included 358 patients with a mean age 67.2 years and diabetes duration of 15.7 years. HbA1c significantly decreased from IDegLira start to all study time points in the overall population (basal group −1.19%; BB group −0.60% at the end of observation). Patients achieving HbA1c <7% levels increased from 12.9% (n = 43) to 40.3% (n = 110) at 18 months. Fasting blood glucose and body weight also significantly decreased in both groups, although more in the BB group. Overall, 14.3% of completed patients had an intensification of treatment (mainly in the basal group) and 48.6% had a simplification of treatment (mainly in the BB group). Conclusions: Switching to IDegLira in a real‐world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, Olga, Masulli, Maria, Nicolucci, Antonio, Maggioni, Aldo Pietro, Sesti, Giorgio, Mocarelli, Paolo, Lucisano, Giuseppe, Sacco, Michele, Signorini, Stefano, Cappellini, Fabrizio, Riccardi, Gabriele, Boemi, Massimo, D'Angelo, Federica, Giansanti, Roberto, Tanase, Laura, Lanari, Luigi, Testa, Ivano, Ricci, Lucia, Pancani, Francesca, Ranchelli, Anna, Vagheggi, Paolo, Scatona, Alessia, Fontana, Lucia, Giorgino, Francesco, Laviola, Luigi, Tarantino, Lucia, Ippolito, Claudia, Gigantelli, Vittoria, Manicone, Mariangela, Conte, Eleonora, Trevisan, Roberto, Scaranna, Cristiana, Rota, Rossella, Corsi, Anna, Dodesini, Alessandro R., Reggiani, Giulio Marchesini, Montesi, Luca, Mazzella, Natalia, Forlani, Gabriele, Caselli, Chiara, Di Luzio, Raffaella, Mazzotti, Arianna, Aiello, Antimo, Barrea, Angelina, Musto, Antonio, D'Amico, Fiorentina, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Trowpea, Vanessa, Sparti, Maria, Italia, Salvatore, Lisi, Enrico, Grasso, Giuseppe, Pezzino, Vincenzo, Insalaco, Federica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, De Franceschi, Maria Serena, Santini, Costanza, Calbucci, Giovanni, Ripani, Raffaella, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Giorda, Carlo B., Romeo, Francesco, Lesina, Annalisa, Comoglio, Marco, Bonetto, Caterina, Robusto, Anna, Nada, Elisa, Asprino, Vincenzo, Cetraro, Rosa, Impieri, Michelina, Lucchese, Giuseppe, Donnarumma, Giovanna, Tizio, Biagio, Clemente, Gennaro, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Cordera, Renzo, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, Antenucci, Daniela, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, Iannarelli, Rossella, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, w Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Buzzetti, Raffaella, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Di Benedetto, Antonino, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Iovine, Ciro, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Vedovato, Monica, Guarneri, Gabriella, Lapolla, Annunziata, Fedele, Domenico, Sartore, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Giordano, Carla, Galluzzo, Aldo, Torregrossa, Vittoria, Dall'Aglio, Elisabetta, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Perriello, Gabriele, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Consoli, Agostino, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Zavaroni, Donatella, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Anichini, Roberto, Corsini, Elisa, Tedeschi, Anna, Gaglianò, Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Citro, Giuseppe, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Calabrese, Maria, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Di Bartolo, Paolo, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Babini, Anna Carla, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Pugliese, Giuseppe, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Lauro, Davide, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Leotta, Sergio, Suraci, Concetta, De Cosmo, Salvatore, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Dotta, Francesco, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Cannarsa, Emanuela, Forte, Elisa, Tamburo, Lucilla, Fornengo, Paolo, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Tonutti, Laura, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Maggioni, Aldo P, Rivellese, Angela A, Giorda, Carlo B, La Macchia, Olga, Bossi, Antonio C, and di Bartolo, Paolo

Published
2017
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25. Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial

Author

Proietto, Joseph, Stranks, Stephen, Chen, Roger, O'Neal, David, Pape, Alexia, Forbes, Mark, Morbey, Claire, Luger, Anton, Hanusch, Ursula, Schnack, Christoph, Fliesser-Goerzer, Evelyn, Hoelzl, Bertram, Ebenbichler, Christoph, Prager, Rudolf, Van Gaal, Luc, Vercammen, Chris, Scheen, Andre, Mathieu, Chantal, Duyck, Francis, Nobels, Frank, Ruige, Johannes, Aggarwal, Naresh, Woo, Vincent, St-Pierre, Bruno, Dumas, Richard, Hramiak, Irene, Elliott, Thomas, Krarup Hansen, Troels, Henriksen, Jan Erik, Gram, Jeppe, Lihn, Aina, Bruun, Jens, Saltevo, Juha, Taurio, Jyrki, Strand, Jorma, Valle, Timo, Nieminen, Sakari, Pietilainen, Kirsi, Guerci, Bruno, Hadjadj, Samy, Cariou, Bertrand, Verges, Bruno, Borot, Sophie, Penfornis, Alfred, Schaum, Thomas, Tschoepe, Diethelm, Marck, Cornelia, Horacek, Thomas, Rose, Ludger, Klausmann, Gerhard, Luedemann, Joerg, Appelt, Steffi, Aigner, Ulrich, Goebel, Rolf, Behnke, Thomas, Ziegler, Anette-Gabriele, Peterfai, Eva, Kerenyi, Zsuzsanna, Oroszlan, Tamas, Kiss, Gyula G., Konyves, Laszlo, Piros, Gyorgyi, Phillip, Moshe, Mosenzon, Ofri, Shehadeh, Naim, Adawi, Faiad, Wainstein, Julio, Dotta, Francesco, Piatti, Piermarco, Genovese, Stefano, Consoli, Agostino, Di Bartolo, Paolo, Mannucci, Edoardo, Giordano, Carla, Lapolla, Annunziata, Aguilar, Carlos, Esteban, Alberto, Ruiz, Bazzoni, Ramirez, Guillermo Mondragon, Pelayo Orozco, Emilia, Alejandro, Carlos, de Alba, Stobschinski, Medina Pech, Carlos, Garza Ruiz, Jose, Sauque Reyna, Leobardo, Llamas Esperon, Guillermo, Nevarez Ruiz, Luis Alejandro, Vidrio Velazquez, Maricela, Flores Lozano, Fernando, Gonzalez Gonzalez, Jose Gerardo, Garcia-Hernandez, Pedro Alberto, Araujo-Silva, Roberto, Villeda - Espinosa, Efrain, Mistodie, Cristina, Popescu, Daniela, Constantin, Ciprian, Nicolau, Alina, Popa, Bogdan, Timar, Romulus, Serafinceanu, Cristian, Pintilei, Ella, Soto, Alfonso, Gimenez, Margarita, Merino-Torres, Juan Francisco, Morales, Cristobal, Mezquita, Pedro, Jendle, Johan, Tengmark, Bengt-Olov, Eriksson, Jan, Londahl, Magnus, Eliasson, Bjorn, Gunstone, Anthony, Heller, Simon, Darzy, Ken, Mansell, Peter, Davies, Melanie, Reed, Rory, Browne, Duncan, Courtney, Hamish, Turner, Wayne, Blagden, Mark, McCrimmon, Rory, Bergenstal, Richard, Lane, Wendy, Lucas, Kathryn, White, Alexander, Bao, Shichun, White, Judith, Jantzi, Curtis, Rasouli, Neda, Ervin, William, Lewy-Alterbaum, Lorena, Handelsman, Yehuda, Miranda-Palma, Bresta, Cleland, Alan, Fink, Raymond, Rodbard, Helena, Nakhle, Samer, Greenberg, Craig, Schorr, Alan, Bays, Harold, Simmons, Debra, Klein, Eric, Kane, Laurie, Fishman, Norman, Ipp, Eli, Garg, Satish, Bhargava, Anuj, Singh, Michelle Zaniewski, Rosenstock, Julio, Thrasher, James, Warren, Mark, Young, Laura, Aroda, Vanita, Pettus, Jeremy, Liljenquist, David, Busch, Robert, Dandona, Paresh, Wise, Jonathan, Kayne, David, Biggs, William, Hansen, Lars, Griffen, Steven C, Tschöpe, Diethelm, Thorén, Fredrik, Xu, John, and Langkilde, Anna Maria

Published
2017
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26. Extracellular vesicles number and cell subtype may be influenced by diabetes mellitus and metformin in patients at high cardiovascular risk

Author

Simeone, Paola G., primary, Liani, Rossella, additional, Bologna, Giuseppina, additional, Tripaldi, Romina, additional, Di Castelnuovo, Augusto, additional, Simeone, Pasquale, additional, D'Ardes, Damiano, additional, Miscia, Sebastiano, additional, Cipollone, Francesco, additional, Marchisio, Marco, additional, Consoli, Agostino, additional, Lanuti, Paola, additional, and Santilli, Francesca, additional

Published
2023
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27. Drugs territorialization in the era of PNRR: perspectives, opportunities and considerations from a panel of experts

Author

Marata, Anna Maria, primary, Marrocco, Walter, additional, Arcangeli, Emanuela, additional, Battistini, Mattia, additional, Buzzetti, Giuliano, additional, Candido, Riccardo, additional, Casadei, Gianluigi, additional, Cattel, Francesco, additional, Cavaliere, Arturo, additional, Consoli, Agostino, additional, Corrao, Giovanni, additional, Didoni, Guido, additional, Di Gesù, Mauro, additional, Giovanzana, Alberto, additional, Lenzi, Matteo, additional, Medaglia, Massimo, additional, Meloncelli, Marta, additional, Palcic, Stefano, additional, Pani, Marcello, additional, Patarnello, Francesca, additional, Pria, Emanuele, additional, Scaduto, Dario, additional, Tozzi, Valeria, additional, Zibellini, Marco, additional, and Crovato, Elisa, additional

Published
2022
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29. Health care organization and use of technological devices in people with diabetes in Italy: Results from a survey of the Working Group on Diabetes and Technology

Author

Pitocco, Dario, primary, Laurenzi, Andrea, additional, Tomaselli, Letizia, additional, Assaloni, Roberta, additional, Consoli, Agostino, additional, Di Bartolo, Paolo, additional, Guardasole, Vincenzo, additional, Lombardo, Fortunato, additional, Maffeis, Claudio, additional, Rossi, Antonio, additional, Gesuita, Rosaria, additional, Di Molfetta, Sergio, additional, Rigamonti, Andrea, additional, Scaramuzza, Andrea, additional, Irace, Concetta, additional, and Cherubini, Valentino, additional

Published
2022
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31. Short-term effectiveness of dapagliflozin versus DPP-4 inhibitors in elderly patients with type 2 diabetes: a multicentre retrospective study.

Author

Morieri, M. L., Raz, I., Consoli, A., Rigato, M., Lapolla, A., Broglio, F., Bonora, E., Avogaro, A., Fadini, G. P., for the DARWIN-FUP network, Ginestra, Federica, Formoso, Gloria, Consoli, Agostino, Andreozzi, Francesco, Sesti, Giorgio, Turco, Salvatore, Lucibelli, Luigi, Gatti, Adriano, Aldigeri, Raffaella, and Dei Cas, Alessandra

Published
2023
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32. Effectiveness and Tolerability of Once-Weekly GLP-1 Receptor Agonists in Clinical Practice: A Focus on Switching Between Once-Weekly Molecules in Type 2 Diabetes

Author

Di Dalmazi, Giulia, primary, Coluzzi, Sara, additional, Baldassarre, Maria Pompea Antonia, additional, Ghit, Amr, additional, Graziano, Giusi, additional, Rossi, Maria Chiara, additional, Ciappini, Beatrice, additional, Milo, Marica, additional, Carrieri, Federica, additional, Nicolucci, Antonio, additional, Consoli, Agostino, additional, and Formoso, Gloria, additional

Published
2022
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34. Effect of an l-Carnitine–Containing Peritoneal Dialysate on Insulin Sensitivity in Patients Treated With CAPD: A 4-Month, Prospective, Multicenter Randomized Trial

Author

Bonomini, Mario, Di Liberato, Lorenzo, Del Rosso, Goffredo, Stingone, Antonio, Marinangeli, Giancarlo, Consoli, Agostino, Bertoli, Silvio, De Vecchi, Amedeo, Bosi, Emanuele, Russo, Roberto, Corciulo, Roberto, Gesualdo, Loreto, Giorgino, Francesco, Cerasoli, Paolo, Di Castelnuovo, Augusto, Monaco, Maria Pia, Shockley, Ty, Rossi, Claudia, and Arduini, Arduino

Published
2013
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35. Drugs territorialization in the era of PNRR: perspectives, opportunities and considerations from a panel of experts

Author

Marata, Anna Maria, Marrocco, Walter, Arcangeli, Emanuela, Battistini, Mattia, Buzzetti, Giuliano, Candido, Riccardo, Casadei, Gianluigi, Cattel, Francesco, Cavaliere, Arturo, Consoli, Agostino, Corrao, Giovanni, Didoni, Guido, Di Gesù, Mauro, Giovanzana, Alberto, Lenzi, Matteo, Medaglia, Massimo, Meloncelli, Marta, Palcic, Stefano, Pani, Marcello, Patarnello, Francesca, Pria, Emanuele, Scaduto, Dario, Tozzi, Valeria, Zibellini, Marco, Crovato, Elisa, Marata, Anna Maria, Marrocco, Walter, Arcangeli, Emanuela, Battistini, Mattia, Buzzetti, Giuliano, Candido, Riccardo, Casadei, Gianluigi, Cattel, Francesco, Cavaliere, Arturo, Consoli, Agostino, Corrao, Giovanni, Didoni, Guido, Di Gesù, Mauro, Giovanzana, Alberto, Lenzi, Matteo, Medaglia, Massimo, Meloncelli, Marta, Palcic, Stefano, Pani, Marcello, Patarnello, Francesca, Pria, Emanuele, Scaduto, Dario, Tozzi, Valeria, Zibellini, Marco, and Crovato, Elisa

Abstract

This document illustrates the results of the work of two interdisciplinary and multistakeholder panels (researchers, public institutions, and industry representatives) on drug territorialization and digitalization, organized as part of a residential seminar held on 30 September and 1st October 2021. Arising from some considerations about the demand for health and the provisions of the National Recovery and Resilience Plan (PNRR), the discussion touched various aspects of managing the transition from current to future management models. The importance of identifying criteria for prioritizing interventions in the area emerged: different methods of drug delivery, scientific information and measurement, re-evaluation of pathologies that can be managed in this area. Finally, the role of digitization within this change was explored. The opinions provided by the experts move towards making the most of the opportunities arising from PNRR, in terms of investments in healthcare and data application, with a view to improve health system efficiency, patient care and related outcomes.

Published
2022

36. Efficacy of Dapagliflozin in Southern Europe Across the Spectrum of Characteristics of Type 2 Diabetes: An International Real-World Analysis

Author

Fadini,Gian Paolo, Morales,Cristobal, Caballero,Irene, González,Beatriz, Tentolouris,Nikolaos, Consoli,Agostino, Fadini,Gian Paolo, Morales,Cristobal, Caballero,Irene, González,Beatriz, Tentolouris,Nikolaos, and Consoli,Agostino

Abstract

Gian Paolo Fadini,1 Cristobal Morales,2 Irene Caballero,2 Beatriz González,2 Nikolaos Tentolouris,3 Agostino Consoli4 1Division of Metabolic Diseases, Department of Medicine, University of Padova, Padua, Italy; 2Hospital Virgen Macarena (Sevilla); Hospital Vithas (Sevilla), Sevilla, Spain; 3Diabetes Centre, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece; 4Department of Medicine and Aging Sciences (DMSI) and Center of Advanced Studies and Technologies (CAST), University of Chieti, Chieti, ItalyCorrespondence: Gian Paolo Fadini, Department of Medicine, University of Padova, Via Giustiniani 2, Padova, 35128, Italy, Tel +39 049 8214318, Email gianpaolo.fadini@unipd.itPurpose: To extend a prior real-world analysis (DARWIN-T2D) of patients with type 2 diabetes initiating dapagliflozin in Italy, Greece, and Spain by evaluating changes in glycemic and extra-glycemic endpoints after initiation of dapagliflozin.Patients and Methods: The association among demographic/clinical characteristics and the change in glycemic and extraglycemic effectiveness endpoints during the observation period was assayed using a mixed effects model.Results: A total of 1438 (860 males; 59.8%) patients were evaluated; patients were followed for a mean of 5.6 months. At baseline, 93.4% and 61.9% of patients were on concomitant metformin and insulin, respectively. A significant mean decrease in HbA1c from 8.7% to 7.5% was observed. The mixed model used also revealed several associations between different glycemic and laboratory parameters and patient characteristics at baseline; insulin use was significantly associated with lower HbA1c. Patients with BMI ≥ 30 kg/m2 experienced greater weight loss than those with BMI < 30 kg/m2. A consistent glucose-lowering effect of dapagliflozin was seen in all subgroups of patients, including those with stage 2 renal impairment and cardiovascular diseas

Published
2022

37. Additional file 1 of Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss

Author

Simeone, Paola, Tripaldi, Romina, Michelsen, Annika, Ueland, Thor, Liani, Rossella, Ciotti, Sonia, Birkeland, K��re I., Gulseth, Hanne L., Di Castelnuovo, Augusto, Cipollone, Francesco, Aukrust, P��l, Consoli, Agostino, Halvorsen, Bente, and Santilli, Francesca

Abstract

Additional file 1. 1. Methods 1.1 Eligibility criteria 2. Supplemental Table 1 3. Supplemental Figure 1.

Published
2022
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38. LDL-cholesterol control in the primary prevention of cardiovascular diseases: An expert opinion for clinicians and health professionals

Author

Poli, Andrea, Catapano, Alberico L, Corsini, Alberto, Manzato, Enzo, Werba, José Pablo, Catena, Gabriele, Cetin, Irene, Cicero, Arrigo F G, Cignarella, Andrea, Colivicchi, Furio, Consoli, Agostino, Landi, Francesco, Lucarelli, Maurizio, Manfellotto, Dario, Marrocco, Walter, Parretti, Damiano, Perrone Filardi, Pasquale, Pirillo, Angela, Sesti, Giorgio, Volpe, Massimo, Marangoni, Franca, Poli, A., Catapano, A. L., Corsini, A., Manzato, E., Werba, J. P., Catena, G., Cetin, I., Cicero, A. F. G., Cignarella, A., Colivicchi, F., Consoli, A., Landi, F., Lucarelli, M., Manfellotto, D., Marrocco, W., Parretti, D., Perrone Filardi, P., Pirillo, A., Sesti, G., Volpe, M., and Marangoni, F.

Subjects
Primary prevention, Cardiovascular disease, Cardiovascular risk, LDL-cholesterol, Risk factors, Settore BIO/14 - Farmacologia, Settore MED/40 - Ginecologia e Ostetricia
Abstract

Aims: Although adequate clinical management of patients with hypercholesterolemia without a history of known cardiovascular disease is essential for prevention, these subjects are often disregarded. Furthermore, the scientific literature on primary cardiovascular prevention is not as rich as that on secondary prevention; finally, physicians often lack adequate tools for the effective management of subjects in primary prevention and have to face some unsolved relevant issues. This document aims to discuss and review the evidence available on this topic and provide practical guidance. Data synthesis: Available algorithms and risk charts represent the main tool for the assessment of cardiovascular risk in patients in primary prevention. The accuracy of such an estimate can be substantially improved considering the potential contribution of some additional risk factors (C-reactive protein, lipoprotein(a), family history of cardiovascular disease) and conditions (environmental pollution, sleep quality, socioeconomic status, educational level) whose impact on the cardiovascular risk has been better understood in recent years. The availability of non-invasive procedures to evaluate subclinical atherosclerosis may help to identify subjects needing an earlier intervention. Unveiling the presence of these conditions will improve cardiovascular risk estimation, granting a more appropriate intervention. Conclusions: The accurate assessment of cardiovascular risk in subjects in primary prevention with the use of algorithms and risk charts together with the evaluation of additional factors will allow physicians to approach each patient with personalized strategies, which should translate into an increased adherence to therapy and, as a consequence, a reduced cardiovascular risk.

Published
2022

39. Additional file 1 of Semaglutide reduces cardiovascular events regardless of metformin use: a post hoc subgroup analysis of SUSTAIN 6 and PIONEER 6

Author

Husain, Mansoor, Consoli, Agostino, De Remigis, Alessandra, Pettersson Meyer, Anna Sina, Rasmussen, Søren, and Bain, Stephen

Subjects
endocrine system diseases, digestive, oral, and skin physiology, nutritional and metabolic diseases
Abstract

Additional file 1: Figure S1. CV outcomes by metformin use at baseline (unadjusted analysis). Figure S2. CV outcomes by metformin use at baseline censored for initiation and discontinuation of metformin. Figure S3. CV outcomes by metformin use at baseline adjusted for time-dependent metformin use during trial (yes/no). Figure S4. CV outcomes and all-cause mortality with semaglutide* vs placebo by baseline metformin use (SUSTAIN 6). Figure S5. CV outcomes and all-cause mortality with semaglutide* vs placebo by baseline metformin use (PIONEER 6). Figure S6. CV outcomes and mortality by baseline metformin use using inverse probability weighting.

Published
2022
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42. Welcoming teleretinography into diabetes integrated care

Author

Perilli, Roberto, primary, Mariotti, Silvio P, additional, Mastropasqua, Leonardo, additional, Bandello, Francesco M, additional, Grigioni, Mauro, additional, Tarricone, Rosanna, additional, Petracca, Francesco, additional, and Consoli, Agostino, additional

Published
2021
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44. Insulin resistance and NAFLD may influence memory performance in obese patients with prediabetes or newly-diagnosed type 2 diabetes

Author

Vadini, Francesco, primary, Simeone, Paola G., additional, Desideri, Giovambattista, additional, Liani, Rossella, additional, Tripaldi, Romina, additional, Ciotti, Sonia, additional, Tartaro, Armando, additional, Guagnano, Maria T., additional, Di Castelnuovo, Augusto, additional, Cipollone, Francesco, additional, Consoli, Agostino, additional, and Santilli, Francesca, additional

Published
2021
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46. Cardiovascular risk management in type 2 diabetes mellitus: A joint position paper of the Italian Cardiology (SIC) and Italian Diabetes (SID) Societies

Author

Avogaro, Angelo, primary, Barillà, Francesco, additional, Cavalot, Franco, additional, Consoli, Agostino, additional, Federici, Massimo, additional, Mancone, Massimo, additional, Paolillo, Stefania, additional, Pedrinelli, Roberto, additional, Perseghin, Gianluca, additional, Perrone Filardi, Pasquale, additional, Scicali, Roberto, additional, Sinagra, Gianfranco, additional, Spaccarotella, Carmen, additional, Indolfi, Ciro, additional, and Purrello, Francesco, additional

Published
2021
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47. Prevention Italy 2021 - An update of the 2018 Consensus document and recommendations for the prevention of cardiovascular disease in Italy [Prevenzione Italia 2021 Un update del Documento di consenso e raccomandazioni per la prevenzione cardiovascolare in Italia]

Author

Battistoni, A, Gallo, G, Aragona, C, Barchiesi, F, Basolo, A, Bellone, S, Bellotti, P, Bertolotti, M, Bianco, A, Biffi, A, Borghi, C, Cicero, A, Consoli, A, Corsini, A, Desideri, G, Di Giacinto, B, Fernando, F, Ferri, C, Galiuto, L, Grassi, D, Grassi, G, Icardi, G, Indolfi, C, Lodi, E, Modena, M, Muiesan, M, Nati, G, Orsi, A, Palermi, S, Parati, G, Passantino, A, Patelli, A, Pelliccia, A, Pengo, M, Filardi, P, Perseghin, G, Pirro, M, Pontremoli, R, Rengo, G, Ricotti, R, Rizzoni, D, Rocca, B, Rotella, C, Rubattu, S, Salvetti, G, Sciacqua, A, Serdoz, A, Sirico, F, Squeo, M, Tocci, G, Trimarco, B, Vigili de Kreutzenberg, S, Volpe, R, Volpe, M, Battistoni, Allegra, Gallo, Giovanna, Aragona, Caterina Oriana, Barchiesi, Fabio, Basolo, Alessio, Bellone, Simonetta, Bellotti, Paolo, Bertolotti, Marco, Bianco, Andrea, Biffi, Alessandro, Borghi, Claudio, Cicero, Arrigo Francesco Giuseppe, Consoli, Agostino, Corsini, Alberto, Desideri, Giovambattista, Di Giacinto, Barbara, Fernando, Fredrik, Ferri, Claudio, Galiuto, Leonarda, Grassi, Davide, Grassi, Guido, Icardi, Giancarlo, Indolfi, Ciro, Lodi, Elisa, Modena, Maria Grazia, Muiesan, Maria Lorenza, Nati, Giulio, Orsi, Andrea, Palermi, Stefano, Parati, Gianfranco, Passantino, Andrea, Patelli, Alessandra, Pelliccia, Antonio, Pengo, Martino, Filardi, Pasquale Perrone, Perseghin, Gianluca, Pirro, Matteo, Pontremoli, Roberto, Rengo, Giuseppe, Ricotti, Roberta, Rizzoni, Damiano, Rocca, Bianca, Rotella, Carlo, Rubattu, Speranza, Salvetti, Guido, Sciacqua, Angela, Serdoz, Andrea, Sirico, Felice, Squeo, Maria Rosaria, Tocci, Giuliano, Trimarco, Bruno, Vigili de Kreutzenberg, Saula, Volpe, Roberto, Volpe, Massimo, Battistoni, A, Gallo, G, Aragona, C, Barchiesi, F, Basolo, A, Bellone, S, Bellotti, P, Bertolotti, M, Bianco, A, Biffi, A, Borghi, C, Cicero, A, Consoli, A, Corsini, A, Desideri, G, Di Giacinto, B, Fernando, F, Ferri, C, Galiuto, L, Grassi, D, Grassi, G, Icardi, G, Indolfi, C, Lodi, E, Modena, M, Muiesan, M, Nati, G, Orsi, A, Palermi, S, Parati, G, Passantino, A, Patelli, A, Pelliccia, A, Pengo, M, Filardi, P, Perseghin, G, Pirro, M, Pontremoli, R, Rengo, G, Ricotti, R, Rizzoni, D, Rocca, B, Rotella, C, Rubattu, S, Salvetti, G, Sciacqua, A, Serdoz, A, Sirico, F, Squeo, M, Tocci, G, Trimarco, B, Vigili de Kreutzenberg, S, Volpe, R, Volpe, M, Battistoni, Allegra, Gallo, Giovanna, Aragona, Caterina Oriana, Barchiesi, Fabio, Basolo, Alessio, Bellone, Simonetta, Bellotti, Paolo, Bertolotti, Marco, Bianco, Andrea, Biffi, Alessandro, Borghi, Claudio, Cicero, Arrigo Francesco Giuseppe, Consoli, Agostino, Corsini, Alberto, Desideri, Giovambattista, Di Giacinto, Barbara, Fernando, Fredrik, Ferri, Claudio, Galiuto, Leonarda, Grassi, Davide, Grassi, Guido, Icardi, Giancarlo, Indolfi, Ciro, Lodi, Elisa, Modena, Maria Grazia, Muiesan, Maria Lorenza, Nati, Giulio, Orsi, Andrea, Palermi, Stefano, Parati, Gianfranco, Passantino, Andrea, Patelli, Alessandra, Pelliccia, Antonio, Pengo, Martino, Filardi, Pasquale Perrone, Perseghin, Gianluca, Pirro, Matteo, Pontremoli, Roberto, Rengo, Giuseppe, Ricotti, Roberta, Rizzoni, Damiano, Rocca, Bianca, Rotella, Carlo, Rubattu, Speranza, Salvetti, Guido, Sciacqua, Angela, Serdoz, Andrea, Sirico, Felice, Squeo, Maria Rosaria, Tocci, Giuliano, Trimarco, Bruno, Vigili de Kreutzenberg, Saula, Volpe, Roberto, and Volpe, Massimo

Published
2021

48. Cardiovascular risk management in type 2 diabetes mellitus: a joint position paper of the Italian Cardiology (SIC) and Italian Diabetes (SID) Societies

Author

Avogaro, A, Barillà, F, Cavalot, F, Consoli, A, Federici, M, Mancone, M, Paolillo, S, Pedrinelli, R, Perseghin, G, Filardi, P, Scicali, R, Sinagra, G, Spaccarotella, C, Indolfi, C, Purrello, F, Avogaro, Angelo, Barillà, Francesco, Cavalot, Franco, Consoli, Agostino, Federici, Massimo, Mancone, Massimo, Paolillo, Stefania, Pedrinelli, Roberto, Perseghin, Gianluca, Filardi, Pasquale Perrone, Scicali, Roberto, Sinagra, Gianfranco, Spaccarotella, Carmen, Indolfi, Ciro, Purrello, Francesco, Avogaro, A, Barillà, F, Cavalot, F, Consoli, A, Federici, M, Mancone, M, Paolillo, S, Pedrinelli, R, Perseghin, G, Filardi, P, Scicali, R, Sinagra, G, Spaccarotella, C, Indolfi, C, Purrello, F, Avogaro, Angelo, Barillà, Francesco, Cavalot, Franco, Consoli, Agostino, Federici, Massimo, Mancone, Massimo, Paolillo, Stefania, Pedrinelli, Roberto, Perseghin, Gianluca, Filardi, Pasquale Perrone, Scicali, Roberto, Sinagra, Gianfranco, Spaccarotella, Carmen, Indolfi, Ciro, and Purrello, Francesco

Abstract

Aim: This review represents a joint effort of the Italian Societies of Cardiology (SIC) and Diabetes (SID) to define the state of the art in a field of great clinical and scientific interest which is experiencing a moment of major cultural advancements, the cardiovascular risk management in type 2 diabetes mellitus. Data synthesis: Consists of six chapters that examine various aspects of pathophysiology, diagnosis and therapy which in recent months have seen numerous scientific innovations and several clinical studies that require extensive sharing. Conclusions: The continuous evolution of our knowledge in this field confirms the great cultural vitality of these two cultural spheres, which requires, under the leadership of the scientific Societies, an ever greater and effective collaboration.

Published
2021

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