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Deuteration has emerged as a significant method for investigating kinetic isotope effects in chemical reactions. In recent years, research on deuteration has revealed that this reaction often alters the pharmacokinetic or toxicological properties of drug molecules, thereby enhancing their therapeutic effect. Therefore, deuteration is considered as a potential avenue for drug research direction. Since the approval of the first deuterated drug, "deutetrabenazine," by the American Food and Drug Administration (FDA) in 2017, deuteration has been applied in the development of a variety of novel drugs. Research on deuteration technology has matured with the publication of numerous deuteration strategies. This article reviews recently reported strategies for late‐stage selective deuteration, discusses the challenges associated with current deuteration strategies, and presents future prospects for the synthesis of deuterated drugs. [ABSTRACT FROM AUTHOR]

This research work focuses on the recycling of gypsum, a key component of drywall panels commonly used in construction. It proposes this practice as a technically and economically viable strategy that also aligns with the circular economy model. In this context, waste loses its status as refuse and is transformed back into raw material. A technical feasibility analysis was conducted based on a sample extracted from a specific project, which was subjected to characterization tests and mechanical behavior assessments in both laboratory and real construction conditions. Additionally, an economic feasibility analysis was performed by comparing the budgets of the same project in two scenarios: the traditional plastering process and the use of recycled gypsum. This analysis highlighted the fiscal and legal benefits that adopting the circular model could offer to stakeholders in the construction industry. This study began with a market analysis to determine the availability of recyclable material and to assess the multiple benefits that its reuse can provide. Based on the characterization of the material obtained from the construction site and the mechanical tests conducted, the economic advantages were evaluated for contractors as well as for the potential establishment of companies focused on gypsum recycling. All of this analysis was framed within the context of sustainability, emphasizing the positive environmental impacts of this practice, as well as the development of a strategy that serves as a valuable proposal for the construction sector. This work concludes that recycling gypsum in construction projects represents a technically, environmentally, and economically sustainable alternative that can positively transform the industry. [ABSTRACT FROM AUTHOR]

The Gestalt theory of mental completeness in architecture gave rise to the ideas of "positive space" and "negative space". This research digs into the sturdy structural building process of bamboo architecture, which is essentially distinguished by "negative space". It examines how bamboo is articulated in architectural space, while attempting to establish a balance between form and structure, with the goal of discovering the current value and spiritual position that bamboo in architecture represents. Using the Phu Quoc Island Visitor Center in Vietnam as an example, we introduce the strong structure concept and examine its design process in terms of spatial operation technique and strong structural expression logic. The fundamental strategy for creating bamboo architecture under this concept is to take the lead in negative space design and use the material capabilities of bamboo to build structural space prototypes. This further encourages the use of green building materials and offers architects working with bamboo a reference. [ABSTRACT FROM AUTHOR]

Organoids, miniature and simplified in vitro model systems that mimic the structure and function of organs, have attracted considerable interest due to their promising applications in disease modeling, drug screening, personalized medicine, and tissue engineering. Despite the substantial success in cultivating physiologically relevant organoids, challenges remain concerning the complexities of their assembly and the difficulties associated with data analysis. The advent of AI-Enabled Organoids, which interfaces with artificial intelligence (AI), holds the potential to revolutionize the field by offering novel insights and methodologies that can expedite the development and clinical application of organoids. This review succinctly delineates the fundamental concepts and mechanisms underlying AI-Enabled Organoids, summarizing the prospective applications on rapid screening of construction strategies, cost-effective extraction of multiscale image features, streamlined analysis of multi-omics data, and precise preclinical evaluation and application. We also explore the challenges and limitations of interfacing organoids with AI, and discuss the future direction of the field. Taken together, the AI-Enabled Organoids hold significant promise for advancing our understanding of organ development and disease progression, ultimately laying the groundwork for clinical application.

Novel research and development (R&D) institutions are an important organizational form of scientific and technological innovation in China. Novel R&D institutions in life sciences and medicine are oriented toward people’s life and health and play an important role in promoting the development of life sciences and medicine, forming multiple innovation subjects, and building an innovation ecology with active elements. However, their construction is still in an exploration stage, and it is urgent to optimize the construction strategy and form a stable and sustainable development capability. This study used the methods of policy research, on-site research, case study, and expert consultation to summarize the progress of policy promotion and exploration practices of novel R&D institutions in China, analyzed the construction modes and operation mechanisms of similar R&D institutions abroad, and presented challenges in the development of novel R&D institutions in the field of life sciences and medicine in China. On this basis, we proposed the following strategies for optimizing the construction of novel R&D institutions in life sciences and medicine in China: (1) building up a diversified and stable funding mechanism, (2) establishing a differentiated development path, (3) improving the recruiting and cultivating mechanism of outstanding professionals, (4) continuously innovating the organizational form of scientific research, (5) exploiting the advantages of the flexible mechanism for scientific achievement transformation, and (6) enhancing the academic influence of these institutions, thereby promoting the high-quality development of these institutions and the self-reliance and strength of China in science and technology.

Party building, as an important part of party work, has also begun to gradually develop towards the trend of efficiency and informationization. The research constructs the party-building information system of higher vocational colleges and universities on the basis of designing and realizing the party-building portal module, party affairs management module, assessment and evaluation module, and party members’ training and learning module. The party-building information system is thoroughly evaluated using the AHP-fuzzy comprehensive evaluation method. The functions of the party-building information management system constructed in this paper are tested by analyzing the average response time of the system, user concurrency, and system throughput. Construct the evaluation index system for party-building information management systems in higher vocational colleges and calculate the index weights. The five subsystems of the party-building information management system are evaluated comprehensively, according to which the suggestions of party-building informationization construction strategies for higher vocational colleges are put forward. The system response time for 10 types of requests of the party building information system in higher vocational colleges designed in this paper is between 36~113ms. The average response time is 1.32 seconds when the number of concurrent users of the system is 750. The throughput of the system is about 900 per second. The operational effectiveness scores of the five subsystems in the party-building information management system lie between 3.554 and 3.709. The scores of the 4 indicators of each subsystem are also average and good. Based on the results of the study, the construction of party-building information sessions in higher vocational colleges and universities should establish a scientific construction awareness, strengthen the synergy, improve the efficiency of party building, and establish a standardized management system.

Being an emerging family of crystalline porous materials, hydrogen-bonded organic frameworks (HOFs) are types of ordered supramolecular structures that constructed from organic linkers (including those with organometallic units) via mainly hydrogen bonds. HOFs have now attracted increasing attention in various fields, owing to their valued features such as mild synthetic condition, convenient purification/recovery processes, high processibility and diverse functionality. Great potentials have emerged for HOFs in the field of adsorption and separation, especially for the purification of light hydrocarbons that are crucial to the petrochemical industry. Their practical applications, however, is limited as it is rather difficult to maintain their porous architectures only through hydrogen bonds after removing the lattice solvent molecules. Several types of strategies have hence been developed to solve the issue of HOF structure fragility, including introduction of stronger/different forms of intermolecular interactions, adoption of monomers with rigid backbones, integration of appropriate structural interpenetrations, formation of the cross-linked structures, etc. In this review, the common strategies for constructing HOFs and the important role of each method in enhancing the structural stability of HOFs are briefly introduced. Then, the application of robust porous HOFs in various gases adsorptions and separations is carefully summarized, as well as its mechanism is analyzed in detail from the perspective of supramolecular interactions among the frameworks and gas molecules. The current challenges and the future perspectives for HOFs are discussed with respect to the urgent demands in enhancing their performance, which propose a broader vision of HOFs in developing novel functional porous materials.

The Gestalt theory of mental completeness in architecture gave rise to the ideas of “positive space” and “negative space”. This research digs into the sturdy structural building process of bamboo architecture, which is essentially distinguished by “negative space”. It examines how bamboo is articulated in architectural space, while attempting to establish a balance between form and structure, with the goal of discovering the current value and spiritual position that bamboo in architecture represents. Using the Phu Quoc Island Visitor Center in Vietnam as an example, we introduce the strong structure concept and examine its design process in terms of spatial operation technique and strong structural expression logic. The fundamental strategy for creating bamboo architecture under this concept is to take the lead in negative space design and use the material capabilities of bamboo to build structural space prototypes. This further encourages the use of green building materials and offers architects working with bamboo a reference.

Based on the survey and statistics methods, the paper studies the current situation and strategies of rural ecological civilization construction. The results showed that in 2020, compared with 2010, the planting area proportion of organic, green and pollution-free agricultural products, the use intensity of pesticides and fertilizers grew slowly, and the treatment rate of livestock and poultry manure and the comprehensive utilization rate of straw both increased significantly. The public's degree of satisfaction and knowledge of ecological civilization were 67.78 points and 61.72%. The strategy of rural ecological civilization construction in Funiu mountain area was put forward, including developing efficient ecological economy and developing the recycling chain of "resource-intensive processing-waste utilization" relying on mountain resources; continuously improving the rural ecological environment, improving the use of straw, and carrying out a revolution in rural garbage and sewage treatment and toilets in line with local conditions to improve the appearance of villages; promoting ecological living, introducing natural gas into rural areas, developing integrated supply of large and medium-sized biogas in line with local conditions, and integrating agricultural electricity with electricity; actively advocating green consumption and support the development of ecological tourism; carrying out education and publicity for ecological progress. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai University / Shanghai Daxue Xuebao is the property of Journal of Shanghai University (Natural Sciences) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ratiometric fluorescence (FL) probes can eliminate the background interference and provide more accurate detection results than single emission intensity-based nanoprobes. Recently, carbon dots (CDs)-based ratiometric FL probes have received extensive research attention due to their excellent biocompatibility, water solubility, and multi-emission capabilities. In this review, we firstly summarize the construction strategies of CDs-based ratiometric FL probes, including physical mixing, nanohybrid, and dual-emitting CDs strategies. Additionally, we classify the sensing types of CDs-based ratiometric FL probes into five categories according to the difference in spectral variation caused by analytes: "single-response-ON", "single-response-OFF", "double-responses-ON", "double-responses-OFF", and "double-responses-Reverse" types. Finally, a thorough overview of CDs-based ratiometric FL probe applications in ions, molecules, pH, and temperature sensing is provided. We believe this review can show the latest research progress of CDs-based ratiometric FL sensing fields and provide perspectives on future developments for the construction of CDs-based ratiometric FL probes and their potential applications. [ABSTRACT FROM AUTHOR]

Research on self-assembled deoxyribonucleic acid (DNA) nanostructures with different shapes, sizes, and functions has recently made rapid progress owing to its biocompatibility, programmability, and stability. Among these, triangular unit-based DNA nanostructures, which are typically multi-arm DNA tiles, have been widely applied because of their unique structural rigidity, spatial flexibility, and cell permeability. Triangular unit-based DNA nanostructures are folded from multiple single-stranded DNA using the principle of complementary base pairing. Its shape and size can be determined using pre-set scaffold strands, segmented base complementary regions, and sequence lengths. The resulting DNA nanostructures retain the desired sequence length to serve as binding sites for other molecules and obtain satisfactory results in molecular recognition, spatial orientation, and target acquisition. Therefore, extensive research on triangular unit-based DNA nanostructures has shown that they can be used as powerful tools in the biosensing field to improve specificity, sensitivity, and accuracy. Over the past few decades, various design strategies and assembly techniques have been established to improve the stability, complexity, functionality, and practical applications of triangular unit-based DNA nanostructures in biosensing. In this review, we introduce the structural design strategies and principles of typical triangular unit-based DNA nanostructures, including triangular, tetrahedral, star, and net-shaped DNA. We then summarize the functional properties of triangular unit-based DNA nanostructures and their applications in biosensing. Finally, we critically discuss the existing challenges and future trends. [Display omitted] • The advantages of triangular unit-based DNA nanostructure are highlighted. • The construction strategies of triangle-based DNA nanostructures are summarized in detail. • Function and application of triangular unit-based DNA are clarified. • Exist challenges and prospects of triangular unit-based DNA nanostructures are discussed. [ABSTRACT FROM AUTHOR]

Nanozymes have garnered considerable research interest for their unique capacity to bridge nanotechnology and biology. Current studies predominantly concentrate on exploring nanozymes with diverse catalytic activities and their potential applications across various disciplines. Among them, nanoscale metal-organic frameworks (MOFs) are promising nanomaterials for constructing nanozymes. In this review, we firstly introduce the general construction strategies for MOF-based nanozymes. In addition, we also classify the MOF-based nanozymes in detail based on their catalytic performance. Thirdly, the recent research progress of MOF-based nanozymes in the field of biosensing, cancer therapy, antibacterial infection, and antioxidation are also comprehensively reviewed. Finally, we discuss the current challenges and future perspectives of MOF-based nanozymes, with the aim of assisting in their construction and maximizing their potential in bioapplications. It is hoped that we could provide scientists in materials science and biomedical research with valuable and comprehensive information, fostering advancements in interdisciplinary fields. [ABSTRACT FROM AUTHOR]

Copyright of New Architecture is the property of New Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tuberculosis is a chronic consumptive infectious disease, which can cause great damage to human and animal health all over the world. The emergence of multi-drug resistant strains, the unstable protective effect of Bacillus Calmette-Guérin (BCG) vaccine on adults, and the mixed infection with HIV all warn people to exploit new approaches for conquering tuberculosis. At present, there has been significant progress in developing tuberculosis vaccines, such as improved BCG vaccine, subunit vaccine, DNA vaccine, live attenuated vaccine and inactivated vaccine. Among these candidate vaccines, there are some promising vaccines to improve or replace BCG vaccine effect. Meanwhile, the application of adjuvants, prime-boost strategy, immunoinformatic tools and targeting components have been studied concentratedly, and verified as valid means of raising the efficiency of tuberculosis vaccines as well. In this paper, the latest advance in tuberculosis vaccines in recent years is reviewed to provide reliable information for future tuberculosis prevention and treatment.

Copyright of Architectural Journal / Jian Zhu Xue Bao is the property of Architectural Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The huge economic loss and threat to human health caused by bacterial infection have attracted the public's concern, and there is an urgent need to relieve and improve the tough problem. Therefore, it is significant to establish a facile, rapid, and sensitive method for bacterial detection considering the shortcomings of existing methods. Förster resonance energy transfer (FRET)-based sensors have exhibited immense potential and applicability for bacterial detection given their high signal-to-noise ratio and high sensitivity. This review focuses on the development of FRET-based fluorescence assays for bacterial detection. We summarize the principle of FRET-based assays, discuss the commonly used recognition molecules and further introduce three frequent construction strategies. Based on the strategies and materials, relevant applications are presented. Moreover, some restrictions of FRET fluorescence sensors and development prospects are discussed. Suitable donor-acceptor pairs and stable recognition molecules are the essential conditions for sensors to play their roles, and there is still some room for development. Besides, applying FRET fluorescence sensors to point-of-care detection is still difficult. Future developments could focus on near-infrared fluorescent dyes and simultaneous detection of multiple analytes. [ABSTRACT FROM AUTHOR]

Copyright of New Architecture is the property of New Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Nowadays, university libraries are generally faced with the serious problem of "the growth rate of funding is lower than the price increase of digital resources". How to use limited funding to meet the needs of discipline construction and development has become the core problem of library literature resources construction. To make every penny worth, library should focus on the core information needs of users. In order to comprehensively evaluate the level of library literature construction, the article proposes an analyo process based on the citation analysis of the academic outputs of institutional repository, to examine the "collection" and "absence" of the core resource used by university and its schools and establishes a solution that can be promoted. [ABSTRACT FROM AUTHOR]

Stimuli-responsive liposomes, a novel type of nanocarriers, have been widely used in the fields of medicine, food, and cosmetics. This paper provides a comprehensive introduction to the preparation methods, construction strategies, and biological applications of stimuli-responsive liposomes. The review highlights the functional principles of pH-sensitive, redox-sensitive, enzyme-sensitive, heat-sensitive, light-sensitive, and magnetic field-responsive liposomes, and summarizes their applications based on various drug delivery mode. Finally, the article provides an overview of the current challenges and future development prospects for stimuli-responsive liposomes.

Artificially synthesized DNA is involved in the construction of a library of oil tracers due to their unlimited number and no-biological toxicity. The strategy of the construction is proposed by oleophilic Silica-encapsulated DNA nanoparticles, which offers fresh thinking in developing novel tracers, sensors, and molecular machines in engineering & applied sciences based on artificially synthesized DNA blocks., (© 2024 IOP Publishing Ltd.)

Liposomes are widely used in the biological field due to their good biocompatibility and surface modification properties. With the development of biochemistry and material science, many liposome structures and their surface functional components have been modified and optimized one by one, pushing the liposome platform from traditional to functionalized and intelligent, which will better satisfy and expand the needs of scientific research. However, a main limiting factor effecting the efficiency of liposomes is the complicated environmental conditions in the living body. Currently, in order to overcome the above problem, functionalized liposomes have become a very promising strategy. In this paper, binding strategies of liposomes with four main functional elements, namely nucleic acids, antibodies, peptides, and stimuli-responsive motif have been summarized for the first time. In addition, based on the construction characteristics of functionalized liposomes, such as drug-carrying, targeting, long-circulating, and stimulus-responsive properties, a comprehensive overview of their features and respective research progress are presented. Finally, the paper critically presents the limitations of these functionalized liposomes in the current applications and also prospectively suggests the future development directions, aiming to accelerate realization of their industrialization., (© 2024 Wiley‐VCH GmbH.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A great deal of research has explored individuals’ attempts to simplify choices by constructing a consideration set. This research aims to investigate which construction strategy, either inclusion or exclusion, is more likely to be adopted and how the adoption of a particular construction strategy can affect consideration set size while identifying the moderating role of chronic indecisiveness in the construction process. The findings of Study 1 indicate that individuals are more likely to adopt an inclusion strategy to reduce a consideration set to a more manageable size, and that an exclusion strategy results in a larger consideration set. In Study 2, the findings reveal that high-indecisiveness individuals are less likely than low-indecisiveness individuals to select an inclusion strategy, but that high-indecisiveness individuals adopting an inclusion strategy are able to reduce the number of alternatives in a consideration set to a manageable size on par with the size of a consideration set formed by low-indecisiveness individuals without elevating the level of perceived difficulty. The current research contributes to the stream of research on consideration set construction and indecisiveness, and offers useful practical implications for overcoming indecisiveness. Limitations and avenues for further research are also discussed.

As the backbone of social development and progress in the future, college students are the main audience of green civilization moral education. In order to cultivate college students' consciousness of "protecting ecological environment with systems", this paper studies the construction strategies of green civilization moral education in Colleges and universities from the perspective of ecological civilization. Based on the individual characteristics of modern college students and the real life of college students, this study takes 10 universities in China as an example, mainly with the method of investigation and research, supplemented by literature research and comprehensive analysis, carries out a questionnaire survey and summary of the results of 1000 students, combs and analyzes the current situation of the construction of green civilization moral education in Colleges and universities in China, and puts fmward the existing problems. The corresponding construction strategy play its due role in the University ecological moral education, in the combination of theory and practice to improve college students' awareness of the active protection of the ecological environment, accept the values and outlook on life education of ecological civilization construction. Meanwhile, it truly achieves the unity of knowledge and practice, improve the ecological environment with the construction of green civilization moral education in Colleges and universities, and improve the reality of modern ecological civilization construction Effectiveness and controllability. [ABSTRACT FROM AUTHOR]

The reasonable construction and application of business management data processing system not only improve the efficiency of business management and operation, but also improve the level of business information, it also provides abundant and high-quality data resources for standardizing the practice of enterprise management. Therefore, in the "Internet +" mature development environment, we should adhere to the computer information management model as the basis to actively explore the enterprise business management data processing system construction strategy. Based on the analysis of the construction background of business management data processing system, the construction strategy of Business Management Data Processing System under the computer information management model is put forward.

With the development of information technology, it is of great practical significance to construct an intelligent teaching platform for business English to supplement the traditional business English teaching. Through the analysis of the current situation of Business English teaching, we can see that the emphasis on theory teaching has neglected the cultivation of students' Business English practical skills. Facing the new business English application environment, by highlighting the characteristics of professionalism and innovation, giving full play to the advantages of information technology application, and building an intelligent teaching platform for business English, promoting business English teaching in an all-round way and realizing real reform.

• Optical principle for the OMEGA and geometric description of PV array are presented. • A novel construction strategy is proposed via polygon meshes. • Optical parameters of the proposed strategy are obtained with numerical simulation. • Influence factors are analyzed and evaluated. The space solar power station is a gigantic power satellite to provide the earth with continuous energy. The front-end system of space solar power station, solar concentrator, has significant influences on the optical performance. Regarding the proposed orb-shaped membrane energy gathering array scheme, this paper deals with the construction strategy of its large-scale spherical concentrator to reduce the complexity of manufacturing and improve the optical properties. The optical principle of the spherical concentrator is described and the spatial motion characteristic is presented. A novel construction strategy for the large-scale concentrator is proposed via partitioning octahedron on the sphere and polygonal partition. This paper evaluates the optical performance of the concentrator constructed by the novel strategy using ray tracing method. Performance parameters such as optical concentration ratio and collection efficiency are obtained. Comparison with the other strategies are also implemented. In addition, influence factors such as the sun's non-parallelism, the tracking precision, the orbital periodic motion, and the potential blockage effects of microwave transmitting antenna and supporting structure are mathematically discussed and evaluated. The numerical results indicate that the proposed strategy achieves a high collection rate, a small efficiency fluctuation, appropriate energy distribution, and relatively small splicing modules, which is conducive to improve optical performance and decrease difficulty in manufacturing. [ABSTRACT FROM AUTHOR]

With the fast increase in airspace density and high‐safety requirements on aviation, automatic dependent surveillance‐broadcast (ADS‐B) is regarded as the primary method in the next generation air traffic surveillance. The ADS‐B data is broadcast with the plain text without sufficient security measures, which results in various attack patterns emerging. However, in terms of constrictions with laws and regulations, ADS‐B attack data is difficult to collect and obtain, which is essential for data security research studies. To deal with the absence of ADS‐B attack data in real environments, the construction strategy on ADS‐B attack data is proposed. For construction fidelity, ADS‐B data features are analysed and modelled at first. Then the popular and classical attack patterns on ADS‐B data are analysed to establish threat models. Based on the original ADS‐B data sets, the construction strategy is designed to focus on attack target selection, key parameter determination, and mixture strategy, reproducing the attack intentions. The constructed ADS‐B attack data sets are hybrid data sets including the normal and attack data. By simulation analyses, the feasibility and availability of the construction strategy were validated with real ADS‐B data. [ABSTRACT FROM AUTHOR]

Copyright of South Architecture / Nanfang Jianzhu is the property of South Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

As display window of urban vitality, public space carries the colorful life of the residents living here and shows the spiritual outlook of a cenain region. As a rising star, new urban area lacks historical accumulation and smell of fireworks when compared with old urban area. How to stimulate the vitality of public space in new urban area has become an unavoidable problem. In this paper, Honggutan New District of Nanchang City is taken as research object, to analyze the relationship between the representation of population vitality and the physical space in new urban area, and explore strategies for creating vitality of public space in new urban area. [ABSTRACT FROM AUTHOR]

Introduction: Over the past two decades, virus-like particles (VLPs) have been developed as a new generation of vaccines against viral infections. Based on VLPs, chimeric VLPs (chi–VLPs) have been generated through genetic modifications or chemical couplings. For construction of multivalent chi–VLPs vaccines, multiple genetic engineering strategies are continuously being developed. Thus, it is important to provide a summary as reference for researchers in this field. Areas covered: The representative studies on the genetic engineered multivalent chi–VLPs are summarized and mainly focused on chimeric capsid VLPs and chimeric enveloped VLPs. The advantages and limitations of each strategy are also discussed at last, as well as opinions on platform choice and future directions of eVLPs vaccines. Expert opinion: The design of multivalent chi–VLPs vaccines needs to meet the following specifications: 1) the incorporated antigens are suggested to display on the exposed surface of chi–VLPs and do not have excessive adverse effects on the stability of chi–VLPs; 2) the chi–VLPs should elicit protective antibodies against the incorporated antigen as well as the source virus of VLPs. However, there is no requirement of retaining the antigenicity of VLPs when using VLPs solely as carriers for antigens display or drug delivery. [ABSTRACT FROM AUTHOR]

Based on the perspective of ecological concept, this study first interpreted the background of ecological civilization construction, and combed the relationship between ecological concept and small town planning. Second, it expounded the ecological problems of natural resources, economic development, landscape system, social humanities and other aspects in the construction of contemporary small towns. According to the study, the construction of small towns based on the ecological concept should establish the concept of "ecology first", practice "multiple compliance", coordinate the relationship with other planning, make reasonable planning and design in the aspects of town scale, functional orientation, structural form, road traffic, landscape style and features, humanistic characteristics, and strengthen the implementation, supervision and management of planning. Finally, summary and outlook was made, hoping that the study will be of reference value and guidance to the planning and construction of small towns. [ABSTRACT FROM AUTHOR]

In the teaching of economic law courses in colleges and universities, new practical training mode should be introduced to help students to start a business and find a job. In this paper, the clinic type mode is described. Besides, problems in carrying out clinic type teaching of economic law courses in colleges and universities are analyzed. Finally, some countermeasures are accordingly proposed. [ABSTRACT FROM AUTHOR]

Urban green space structure and pattern have been one of the highlights in Landscape Architecture studies, accompanying with urgent demands of promoting ecological spatial structures in urban construction. Focusing on functional connectivity and construction strategies of the structure of green space network in Haidian District of Beijing, this research builds resistance surface and identifies linkages through habitat quality evaluation of the InVEST Model and the simulation with the Least-Cost Model, while adopting functional connectivity index (NL, NC, IIC, PC, and dIIL) to indicate the structural characteristics of green space network at varied distance thresholds. Results reveal that, on the whole, the distance threshold of 2,200 meters is most appropriate for the structure of the existing green space network of Haidian District, when 10 components and 353 linkages are identified and six important nodes and three important linkages that require a protection priority are further determined. Findings also disclose that the forest network of target tree species and that of water network of target water bird species are highly fragmented. Forest network serves in forms of dominant patch structure, local network structure, and fragmented cluster structure in the western mountainous area, the northern plain area, and the southeastern urban area, respectively. Moreover, the research proves that by introducing ten important linkages, the connectivity of forest network can be improved by 1.7 times, completing the overall structure in multiple directions and helping form a stable and resilient structure of the network. Finally, the research puts forward strategies for urban green space construction, including identifying construction objectives and target species, identifying and protecting important nodes and important linkages, and introducing possible important linkages and improving the structure of green space network, to help efficiently improve urban ecological quality. [ABSTRACT FROM AUTHOR]

Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)