23 results on '"Contardo T"'
Search Results
2. P-22 Role of timing to laparoscopic or robotic surgery after neoadjuvant chemoradiotherapy for rectal cancer: The TiMiSNAR trial
- Author
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Monsellato, I., primary, Cassinotti, E., additional, Boni, L., additional, Elmore, U., additional, Delpini, R., additional, Rosati, R., additional, Perinotti, R., additional, Alongi, F., additional, Ruffo, G., additional, Pernazza, G., additional, Cruccu, A., additional, Pulighe, F., additional, De Nisco, C., additional, Morpurgo, E., additional, Contardo, T., additional, Cavaliere, D., additional, Solaini, L., additional, Surgo, A., additional, De Angelis, N., additional, Fiorentino, A., additional, and Orecchia, S., additional
- Published
- 2021
- Full Text
- View/download PDF
3. Deprivazione sociale e inquinamento atmosferico: il biomonitoraggio lichenico come strumento interpretativo
- Author
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Contardo, T., Vannini, A., Paoli, L., Giordani, P., Maccherini, S., and Loppi, S.
- Published
- 2017
4. Biomonitoraggio della qualità dell'aria nei dintorni di un impianto di incenerimento di rifiuti (Valmadrera, Lecco)
- Author
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Contardo, T., Vannini, A., Paoli, L., Giordani, P., and Loppi, S.
- Published
- 2016
5. Fibrosi retroperitoneale e mesenterica. Una 'sindrome da carcinoide' di non frequente riscontro
- Author
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Spivach, A, Sartori, A, Martinolli, S, Contardo, T, Zanconati, Fabrizio, Spivach, A, Sartori, A, Martinolli, S, Contardo, T, and Zanconati, Fabrizio
- Published
- 2007
6. Retroperitoneal and mesenteric fibrosis. An uncommon 'carcinoid syndrome',Fibrosi retroperitoneale e mesenterica. Una 'sindrome da carcinoide' di non frequente riscontro
- Author
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Spivach, A., Sartori, A., Martinolli, S., Contardo, T., and Zanconati, F.
7. Expression levels of circulating miRNAs as biomarkers during multimodal treatment of rectal cancer - TiMiSNAR-mirna: A substudy of the TiMiSNAR Trial (NCT03962088)
- Author
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Giorgio Ercolani, Elisabetta Garibaldi, Leonardo Solaini, Ugo Elmore, Tania Contardo, Roberto Perinotti, C Ceccarelli, Igor Monsellato, Luigi Boni, Riccardo Rosati, Fabio Pulighe, Ludovica Baldari, Enzo Mammano, Sara Orecchia, Giacomo Ruffo, Riccardo Balestri, Valter Torri, Graziano Pernazza, Elena Traverso, Stefania Gori, Benedetta Menegatti, Davide Cavaliere, Vittorio Fusco, Elisa Cassinotti, Carlo De Nisco, Piero Buccianti, Filippo Alongi, Federico Perna, Roberto Delpini, Andrea Coratti, Emilio Morpurgo, Elisa Bertocchi, Monsellato I., Garibaldi E., Cassinotti E., Baldari L., Boni L., Elmore U., Delpini R., Rosati R., Perinotti R., Alongi F., Bertocchi E., Gori S., Ruffo G., Pernazza G., Pulighe F., De Nisco C., Morpurgo E., Contardo T., Mammano E., Perna F., Menegatti B., Coratti A., Buccianti P., Balestri R., Ceccarelli C., Cavaliere D., Solaini L., Ercolani G., Traverso E., Fusco V., Torri V., Orecchia S., Monsellato, Igor, Garibaldi, Elisabetta, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Elmore, Ugo, Delpini, Roberto, Rosati, Riccardo, Perinotti, Roberto, Alongi, Filippo, Bertocchi, Elisa, Gori, Stefania, Ruffo, Giacomo, Pernazza, Graziano, Pulighe, Fabio, De Nisco, Carlo, Morpurgo, Emilio, Contardo, Tania, Mammano, Enzo, Perna, Federico, Menegatti, Benedetta, Coratti, Andrea, Buccianti, Piero, Balestri, Riccardo, Ceccarelli, Cristina, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Traverso, Elena, Fusco, Vittorio, Torri, Valter, and Orecchia, Sara
- Subjects
Oncology ,medicine.medical_specialty ,Neoadjuvant treatment ,Colorectal cancer ,Medicine (miscellaneous) ,Disease ,Disease-Free Survival ,03 medical and health sciences ,Study Protocol ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Liquid biopsy ,Lymph node ,Grading (tumors) ,Pathological ,030304 developmental biology ,Neoplasm Staging ,Randomized Controlled Trials as Topic ,Retrospective Studies ,miRNA ,0303 health sciences ,lcsh:R5-920 ,business.industry ,Rectal Neoplasms ,Chemoradiotherapy ,Biomarker ,Translational research ,medicine.disease ,Combined Modality Therapy ,Neoadjuvant Therapy ,Biomarkers ,MicroRNAs ,Observational Studies as Topic ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,Histopathology ,business ,lcsh:Medicine (General) - Abstract
Background Neoadjuvant chemoradiotherapy followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage (downstaging). Extensive histopathological work-up of the tumor specimen after surgery including tumor regression grading and lymph node status helped to visualize individual tumor sensitivity to chemoradiotherapy, retrospectively. As the response to neoadjuvant chemoradiotherapy is heterogeneous, however, valid biomarkers are needed to monitor tumor response. A relevant number of studies aimed to identify molecular markers retrieved from tumor tissue while the relevance of blood-based biomarkers is less stringent assessed. MicroRNAs are currently under investigation to serve as blood-based biomarkers. To date, no screening approach to identify relevant miRNAs as biomarkers in blood of patients with rectal cancer was undertaken. The aim of the study is to investigate the role of circulating miRNAs as biomarkers in those patients included in the TiMiSNAR Trial (NCT 03465982). This is a biomolecular substudy of TiMiSNAR Trial (NCT03962088). Methods All included patients in the TiMiSNAR Trial are supposed to undergo blood collection at the time of diagnosis, after neoadjuvant treatment, after 1 month from surgery, and after adjuvant chemotherapy whenever indicated. Discussion TiMiSNAR-MIRNA will evaluate the association of variation between preneoadjuvant and postneoadjuvant expression levels of miRNA with pathological complete response. Moreover, the study will evaluate the role of liquid biopsies in the monitoring of treatment, correlate changes in expression levels of miRNA following complete surgical resection with disease-free survival, and evaluate the relation between changes in miRNA during surveillance and tumor relapse. Trial registration Clinicaltrials.gov NCT03962088. Registered on 23 May 2019.
- Published
- 2020
8. Magnetic Emissions from Brake Wear are the Major Source of Airborne Particulate Matter Bioaccumulated by Lichens Exposed in Milan (Italy)
- Author
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Adriana Basile, Aldo Winkler, Stefano Loppi, Andrea Vannini, Tania Contardo, Sergio Sorbo, Winkler, A., Contardo, T., Vannini, A., Sorbo, S., Basile, A., and Loppi, S.
- Subjects
Pollution ,010504 meteorology & atmospheric sciences ,media_common.quotation_subject ,010501 environmental sciences ,lcsh:Technology ,01 natural sciences ,lcsh:Chemistry ,General Materials Science ,Trace metal ,Lichen ,lcsh:QH301-705.5 ,Instrumentation ,0105 earth and related environmental sciences ,media_common ,Fluid Flow and Transfer Processes ,particulate matter ,magnetic biomonitoring ,lichen transplants ,brake wear ,urban air pollution ,Evernia prunastri ,lcsh:T ,Process Chemistry and Technology ,General Engineering ,Particulates ,equipment and supplies ,Magnetic susceptibility ,lcsh:QC1-999 ,Computer Science Applications ,lcsh:Biology (General) ,lcsh:QD1-999 ,Lichen transplant ,lcsh:TA1-2040 ,Environmental chemistry ,Bioaccumulation ,Environmental science ,Magnetic nanoparticles ,lcsh:Engineering (General). Civil engineering (General) ,human activities ,lcsh:Physics - Abstract
The concentration of selected trace elements and the magnetic properties of samples of the lichen Evernia prunastri exposed for 3 months in Milan (Italy) were investigated to test if magnetic properties can be used as a proxy for the bioaccumulation of chemical elements in airborne particulate matter. Magnetic analysis showed intense properties driven by magnetite-like minerals, leading to significant correlations between magnetic susceptibility and the concentration of Fe, Cr, Cu, and Sb. Selected magnetic particles were characterized by Scanning Electron Microscope and Energy Dispersion System microanalyses, and their composition, morphology and grain size supported their anthropogenic, non-exhaust origin. The overall combination of chemical, morphoscopic and magnetic analyses strongly suggested that brake abrasion from vehicles is the main source of the airborne particles accumulated by lichens. It is concluded that magnetic susceptibility is an excellent parameter for a simple, rapid and cost-effective characterization of atmospheric trace metal pollution using lichens.
- Published
- 2020
9. New Interpretative Scales for Lichen Bioaccumulation Data: The Italian Proposal
- Author
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Luca Di Nuzzo, Paolo Giordani, Tania Contardo, Juri Nascimbene, Silvana Munzi, Luca Paoli, Elisabetta Bianchi, Giorgio Brunialti, Elva Cecconi, Fabrizio Monaci, Mauro Tretiach, Luisa Frati, Sonia Ravera, Andrea Vannini, Stefano Loppi, Renato Benesperi, Lorenzo Fortuna, Cecconi, Elva, Fortuna, Lorenzo, Benesperi, Renato, Bianchi, Elisabetta, Brunialti, Giorgio, Contardo, Tania, Di Nuzzo, Luca, Frati, Luisa, Monaci, Fabrizio, Munzi, Silvana, Nascimbene, Juri, Paoli, Luca, Ravera, Sonia, Vannini, Andrea, Giordani, Paolo, Loppi, Stefano, Tretiach, Mauro, Cecconi E., Fortuna L., Benesperi R., Bianchi E., Brunialti G., Contardo T., Nuzzo L.D., Frati L., Monaci F., Munzi S., Nascimbene J., Paoli L., Ravera S., Vannini A., Giordani P., Loppi S., Tretiach M., and Di Nuzzo L. .
- Subjects
Pseudevernia furfuracea ,Pollution ,Background level ,Atmospheric Science ,010504 meteorology & atmospheric sciences ,media_common.quotation_subject ,air pollution ,Evernia prunastri ,trace elements ,Air pollution ,Background levels ,Biomonitoring ,Flavoparmelia caperata ,Lichen transplants ,Native lichens ,Trace elements ,Xanthoria parietina ,Environmental Science (miscellaneous) ,native lichens ,lcsh:QC851-999 ,010501 environmental sciences ,01 natural sciences ,native lichen ,Native lichen ,Lichen ,0105 earth and related environmental sciences ,media_common ,biology ,lichen transplants, air pollution ,background levels ,trace element ,biology.organism_classification ,background level ,Lichen transplant ,lichen transplants ,Bioaccumulation ,Trace element ,Environmental science ,lcsh:Meteorology. Climatology ,Physical geography - Abstract
The interpretation of lichen bioaccumulation data is of paramount importance in environmental forensics and decision-making processes. By implementing basic ideas underlying previous interpretative scales, new dimensionless, species-independent &ldquo, bioaccumulation scales&rdquo, for native and transplanted lichens are proposed. Methodologically consistent element concentration datasets were populated with data from biomonitoring studies relying on native and transplanted lichens. The scale for native lichens was built up by analyzing the distribution of ratios between element concentration data and species-specific background concentration references (B ratios), herein provided for Flavoparmelia caperata and Xanthoria parietina (foliose lichens). The scale for transplants was built up by analyzing the distribution of ratios between element concentration in exposed and unexposed samples (EU ratio) of Evernia prunastri and Pseudevernia furfuracea (fruticose lichens). Both scales consist of five percentile-based classes, namely, &ldquo, Absence of&rdquo, &ldquo, Low&rdquo, Moderate&rdquo, High&rdquo, and &ldquo, Severe&rdquo, bioaccumulation. A comparative analysis of extant interpretative tools showed that previous ones for native lichens suffered from the obsolescence of source data, whereas the previous expert-assessed scale for transplants failed in describing noticeable element concentration variations. The new scales, based on the concept that pollution can be quantified by dimensionless ratios between experimental and benchmark values, overcome most critical points affecting the previous scales.
- Published
- 2019
10. Local Economic Conditions Affect Aedes albopictus Management.
- Author
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Cerri J, Sciandra C, Contardo T, and Bertolino S
- Subjects
- Animals, Italy, Socioeconomic Factors, Humans, Introduced Species economics, Cities, Aedes, Mosquito Control economics, Mosquito Vectors
- Abstract
Invasive mosquitoes are an emerging public health issue, as many species are competent vectors for pathogens. We assessed how multiple environmental and socio-economic factors affected the engagement of municipalities in Italy (n = 7679) in actions against Aedes albopictus, an invasive mosquito affecting human health and well-being, between 2000 and 2020. We collected information about mosquito control from official documents and municipal websites and modeled the role played by multiple environmental and socioeconomic factors characterizing each municipality through the random forest algorithm. Municipalities are more prone to manage A. albopictus if more urbanized, in lowlands and with long infestation periods. Moreover, these variables are more predictive of management in municipalities with a high median income and thus more economic resources. Only 25.5% of Italian municipalities approved regulations for managing A. albopictus, and very few of them were in Southern Italy, the most deprived area of the country. Our findings indicate that local economic conditions moderate the effect of other drivers of mosquito control and ultimately can lead to better management of A. albopictus. If the management of invasive mosquitoes, or other forms of global change, is subjected to local economic conditions, economic inequalities will jeopardize the success of large-scale policies, also raising issues of environmental and climate justice., (© 2024. The Author(s).)
- Published
- 2024
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11. Lichen Biomonitoring of Airborne Microplastics in Milan (N Italy).
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Jafarova M, Contardo T, Aherne J, and Loppi S
- Abstract
This study investigated the deposition of airborne microplastics (MPs) in the urban area of Milan across 12 sites and at a background control site (northern Italy) using 3-month transplants of the fruticose lichen species Evernia prunastri (exposed in triplicate). The primary objective was to evaluate the use of lichen transplants for the assessment of MP deposition; as such, the study sites spanned a gradient in vehicular traffic and population density across four concentric land-use zones (i.e., urban parks, centre, semi-periphery, and periphery). A total of 149 MP particles were detected in the exposed lichen samples; 94.6% were classified as fibres and 5.4% as fragments. The control site and urban parks experienced a similar number of MPs per gram of dry lichen (20-26 MP/g), while a higher number of MPs were detected in central and peripheral areas (44-56 MP/g), with a clear increasing gradient from the city centre towards the periphery. We estimated the MP deposition in Milan to be in the range of 43-119 MPs m
2 /d, indicating that people living in Milan are exposed to airborne MPs, with potential health effects. This study suggests that lichens are suitable biomonitors of airborne MPs under a relatively short exposure of three months in urban environments.- Published
- 2022
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12. The impact of anastomotic leak on long-term oncological outcomes after low anterior resection for mid-low rectal cancer: extended follow-up of a randomised controlled trial.
- Author
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Bao QR, Pellino G, Spolverato G, Restivo A, Deidda S, Capelli G, Ruffolo C, Bianco F, Cuicchi D, Jovine E, Lombardi R, Belluco C, Amato A, La Torre F, Asteria C, Infantino A, Contardo T, Del Bianco P, Delrio P, and Pucciarelli S
- Subjects
- Anastomotic Leak etiology, Disease-Free Survival, Follow-Up Studies, Humans, Neoadjuvant Therapy adverse effects, Neoplasm Recurrence, Local pathology, Prognosis, Retrospective Studies, Proctectomy, Rectal Neoplasms pathology
- Abstract
Purpose: The impact of anastomotic leaks (AL) on oncological outcomes after low anterior resection for mid-low rectal cancer is still debated. The aim of this study was to evaluate overall survival (OS), disease-free survival (DFS), and local and distant recurrence in patients with AL following low anterior resection., Methods: This is an extension of a multicentre RCT (NCT01110798). Kaplan-Meier method and the log-rank test were used to estimate and compare the 3-, 5-, and 10-year OS and DFS, and local and distant recurrence in patients with and without AL. Predictors of OS and DFS were evaluated using the Cox regression analysis as secondary aim., Results: Follow-up was available for 311 patients. Of them, 252 (81.0%) underwent neoadjuvant chemoradiotherapy and 138 (44.3%) adjuvant therapy. AL occurred in 63 (20.3%) patients. At a mean follow-up of 69.5 ± 31.9 months, 23 (7.4%) patients experienced local recurrence and 49 (15.8%) distant recurrence. The 3-, 5-, and 10-year OS and DFS were 89.2%, 85.3%, and 70.2%; and 80.7%, 75.1%, and 63.5% in patients with AL, and 88.9%, 79.8% and 72.3%; and 83.7, 74.2 and 62.8%, respectively in patients without (p = 0.89 and p = 0.84, respectively). At multivariable analysis, AL was not an independent predictor of OS (HR 0.65, 95%CI 0.34-1.28) and DFS (HR 0.70, 95%CI 0.39-1.25), whereas positive circumferential resection margins and pathological stage impaired both., Conclusions: In the context of modern multimodal rectal cancer treatment, AL does not affect long-term OS, DFS, and local and distant recurrence in patients with mid-low rectal cancer., (© 2022. The Author(s).)
- Published
- 2022
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- View/download PDF
13. Assessing the impact of vehicular particulate matter on cultural heritage by magnetic biomonitoring at Villa Farnesina in Rome, Italy.
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Winkler A, Contardo T, Lapenta V, Sgamellotti A, and Loppi S
- Subjects
- Biological Monitoring, Environmental Monitoring methods, Italy, Magnetic Phenomena, Rome, Vehicle Emissions analysis, Air Pollutants analysis, Particulate Matter analysis
- Abstract
Magnetic biomonitoring methodologies were applied at Villa Farnesina, Rome, a masterpiece of the Italian Renaissance, with loggias frescoed by renowned artists such as Raffaello Sanzio. Plant leaves were sampled in September and December 2020 and lichen transplants were exposed from October 2020 to early January 2021 at increasing distances from the main trafficked road, Lungotevere Farnesina, introducing an outdoor vs. indoor mixed sampling design aimed at assessing the impact of vehicular particulate matter (PM) on the Villa Loggias. The magnetic properties of leaves and lichens - inferred from magnetic susceptibility values, hysteresis loops and first order reversal curves - showed that the bioaccumulation of magnetite-like particles, associated with trace metals such as Cu, Ba and Sb, decreased exponentially with the distance from the road, and was mainly linked to metallic emission from vehicle brake abrasion. For the frescoed Halls, ca. 30 m from the road, the exposure to traffic-related emissions was very limited or negligible. Tree and shrub leaves of the Lungotevere and of the Villa's Gardens intercepted much traffic-derived PM, thus being able to protect the indoor cultural heritage and providing an essential conservation service. It is concluded that the joint use of magnetic and chemical analyses can profitably be used for evaluating the impact of particulate pollution on cultural heritage within complex metropolitan contexts as a preventive conservation measure., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
14. Right colectomy with intracorporeal anastomosis for cancer: a prospective comparison between robotics and laparoscopy.
- Author
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Sorgato N, Mammano E, Contardo T, Vittadello F, Sarzo G, and Morpurgo E
- Subjects
- Anastomosis, Surgical methods, Colectomy methods, Humans, Operative Time, Prospective Studies, Retrospective Studies, Treatment Outcome, Colonic Neoplasms surgery, Laparoscopy methods, Robotic Surgical Procedures methods
- Abstract
Robotics in right colectomy are still under debate. Available studies compare different techniques of ileocolic anastomosis but results are non-conclusive. Our study aimed to compare intraoperative outcomes, and short-term postoperative results between robotic and standard laparoscopic right colectomies for cancer with intracorporeal anastomosis (ICA) fashioned with the same technique. All consecutive patients scheduled for laparoscopic or robotic right hemicolectomies with ICA for cancer in two hospitals, one of which is a tertiary care centre, were prospectively enrolled in our prospective observational study, from April 2018 to December 2019. ICA was fashioned with the same stapled hand-sewn technique. Continuous and categorical variables were analysed using t test and chi-squared test as required. Statistical significance was set at p < 0.05. Forty patients underwent laparoscopic surgery, and 48 underwent robotic right colectomy and were included in the intention-to-treat analysis. Operative time was not statistically different between the two groups (robotic group 265.9 min vs laparoscopic group 254.2 min, p = 0.29). The robotic group had a significantly shorter time for stump oversewing (ileum reinforcement: robotic group 9.3 min vs laparoscopic group 14.2 min, p < 0.001; colon reinforcement: robotic 7.7. min, laparoscopy 13.9 min, p < 0.001) and for ICA (robotic 31.6 min vs laparoscopy 43.0, p < 0.001). One patient underwent extracorporeal anastomosis in the robotic group. The short-term outcomes were comparable between standard laparoscopic and robotic right colectomies with ICA. The limitation of the study is its small sample size and the fact that it was done in two institutions under the supervision of one person. Our data demonstrate that intracorporeal ileocolic anastomosis is safe, and faster and easier with robotic systems. Robotics can facilitate more challenging ICA in minimally invasive surgery., (© 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
15. Disentangling sources of trace element air pollution in complex urban areas by lichen biomonitoring. A case study in Milan (Italy).
- Author
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Contardo T, Vannini A, Sharma K, Giordani P, and Loppi S
- Subjects
- Air Pollution analysis, Antimony analysis, Cities, Copper analysis, Italy, Railroads, Soil, Air Pollutants analysis, Biological Monitoring methods, Environmental Monitoring methods, Lichens metabolism, Trace Elements analysis
- Abstract
In this study we investigated the bioaccumulation of selected trace elements in lichen samples transplanted for three months in Milan, Italy, with the aim of assessing the main environmental contaminants and the overall pollution load, and of disentangling the main air pollution sources as well as of estimating fluxes of element deposition. The results highlighted Cu and Sb as important contaminants and suggested a common origin for these two elements from railways and non-exhaust sources of vehicular traffic such as brake abrasion. High or very high global air pollution emerged for all study sites. Source apportionment outlined three main factors, that found reliable correlation with distance from major roads and railways, an industrial plant, and soil resuspension. Ranges of estimated mean annual element deposition rates in the study area were similar to those reported for other cities., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
16. Expression levels of circulating miRNAs as biomarkers during multimodal treatment of rectal cancer - TiMiSNAR-mirna: a substudy of the TiMiSNAR Trial (NCT03962088).
- Author
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Monsellato I, Garibaldi E, Cassinotti E, Baldari L, Boni L, Elmore U, Delpini R, Rosati R, Perinotti R, Alongi F, Bertocchi E, Gori S, Ruffo G, Pernazza G, Pulighe F, De Nisco C, Morpurgo E, Contardo T, Mammano E, Perna F, Menegatti B, Coratti A, Buccianti P, Balestri R, Ceccarelli C, Cavaliere D, Solaini L, Ercolani G, Traverso E, Fusco V, Torri V, and Orecchia S
- Subjects
- Biomarkers blood, Chemoradiotherapy, Combined Modality Therapy, Disease-Free Survival, Humans, Neoadjuvant Therapy, Neoplasm Staging, Observational Studies as Topic, Randomized Controlled Trials as Topic, Retrospective Studies, Treatment Outcome, MicroRNAs blood, Rectal Neoplasms blood, Rectal Neoplasms therapy
- Abstract
Background: Neoadjuvant chemoradiotherapy followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage (downstaging). Extensive histopathological work-up of the tumor specimen after surgery including tumor regression grading and lymph node status helped to visualize individual tumor sensitivity to chemoradiotherapy, retrospectively. As the response to neoadjuvant chemoradiotherapy is heterogeneous, however, valid biomarkers are needed to monitor tumor response. A relevant number of studies aimed to identify molecular markers retrieved from tumor tissue while the relevance of blood-based biomarkers is less stringent assessed. MicroRNAs are currently under investigation to serve as blood-based biomarkers. To date, no screening approach to identify relevant miRNAs as biomarkers in blood of patients with rectal cancer was undertaken. The aim of the study is to investigate the role of circulating miRNAs as biomarkers in those patients included in the TiMiSNAR Trial (NCT03465982). This is a biomolecular substudy of TiMiSNAR Trial (NCT03962088)., Methods: All included patients in the TiMiSNAR Trial are supposed to undergo blood collection at the time of diagnosis, after neoadjuvant treatment, after 1 month from surgery, and after adjuvant chemotherapy whenever indicated., Discussion: TiMiSNAR-MIRNA will evaluate the association of variation between preneoadjuvant and postneoadjuvant expression levels of miRNA with pathological complete response. Moreover, the study will evaluate the role of liquid biopsies in the monitoring of treatment, correlate changes in expression levels of miRNA following complete surgical resection with disease-free survival, and evaluate the relation between changes in miRNA during surveillance and tumor relapse., Trial Registration: Clinicaltrials.gov NCT03962088 . Registered on 23 May 2019.
- Published
- 2020
- Full Text
- View/download PDF
17. Correction to: Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR).
- Author
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Monsellato I, Alongi F, Bertocchi E, Gori S, Ruffo G, Cassinotti E, Baldari L, Boni L, Pernazza G, Pulighe F, De Nisco C, Perinotti R, Morpurgo E, Contardo T, Mammano E, Elmore U, Delpini R, Rosati R, Perna F, Coratti A, Menegatti B, Gentilli S, Baroffio P, Buccianti P, Balestri R, Ceccarelli C, Torri V, Cavaliere D, Solaini L, Ercolani G, Traverso E, Fusco V, Rossi M, Priora F, Numico G, Franzone P, and Orecchia S
- Abstract
Following publication of the original article [1], the authors reported that the family name of the author, Ludovica Baldari, was misspelled.
- Published
- 2020
- Full Text
- View/download PDF
18. Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR).
- Author
-
Monsellato I, Alongi F, Bertocchi E, Gori S, Ruffo G, Cassinotti E, Baldari L, Boni L, Pernazza G, Pulighe F, De Nisco C, Perinotti R, Morpurgo E, Contardo T, Mammano E, Elmore U, Delpini R, Rosati R, Perna F, Coratti A, Menegatti B, Gentilli S, Baroffio P, Buccianti P, Balestri R, Ceccarelli C, Torri V, Cavaliere D, Solaini L, Ercolani G, Traverso E, Fusco V, Rossi M, Priora F, Numico G, Franzone P, and Orecchia S
- Subjects
- Adult, Aged, Humans, Middle Aged, Young Adult, Disease-Free Survival, Minimally Invasive Surgical Procedures, Prognosis, Prospective Studies, Time Factors, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Adenocarcinoma drug therapy, Adenocarcinoma surgery, Chemoradiotherapy, Laparoscopy, Neoadjuvant Therapy, Rectal Neoplasms drug therapy, Rectal Neoplasms surgery
- Abstract
Background: The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not complete until after several months. More recently, increasing pathologic Complete Response rates have been demonstrated to be correlated with longer time interval. The purpose of the trial is to demonstrate if delayed timing of surgery after neoadjuvant chemoradiotherapy actually affects pathologic Complete Response and reflects on disease-free survival and overall survival rather than standard timing., Methods: The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer. Three-hundred and forty patients will be randomized on an equal basis to either robotic-assisted/standard laparoscopic rectal cancer surgery after 8 weeks or robotic-assisted/standard laparoscopic rectal cancer surgery after 12 weeks., Discussion: To date, it is well-know that pathologic Complete Response is associated with excellent prognosis and an overall survival of 90%. In the Lyon trial the rate of pCR or near pathologic Complete Response increased from 10.3 to 26% and in retrospective studies the increase rate was about 23-30%. These results may be explained on the relationship between radiation therapy and tumor regression: DNA damage occurs during irradiation, but cellular lysis occurs within the next weeks. Study results, whether confirmed that performing surgery after 12 weeks from neoadjuvant treatment is advantageous from a technical and oncological point of view, may change the current pathway of the treatment in those patient suffering from rectal cancer., Trial Registration: ClinicalTrials.gov NCT3465982.
- Published
- 2019
- Full Text
- View/download PDF
19. From Laparoscopic Right Colectomy with Extracorporeal Anastomosis to Robot-Assisted Intracorporeal Anastomosis to Totally Robotic Right Colectomy for Cancer: The Evolution of Robotic Multiquadrant Abdominal Surgery.
- Author
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Scotton G, Contardo T, Zerbinati A, Tosato SM, Orsini C, and Morpurgo E
- Subjects
- Aged, Anastomosis, Surgical adverse effects, Colectomy adverse effects, Conversion to Open Surgery statistics & numerical data, Female, Humans, Laparoscopy adverse effects, Male, Middle Aged, Operative Time, Postoperative Complications epidemiology, Postoperative Complications etiology, Retrospective Studies, Robotic Surgical Procedures adverse effects, Anastomosis, Surgical methods, Colectomy methods, Colonic Neoplasms surgery, Laparoscopy methods, Robotic Surgical Procedures methods
- Abstract
Background: Intracorporeal anastomosis (IA) in right colectomies shows many advantages over extracorporeal anastomosis (EA). Many difficulties encountered in laparoscopic IA can be overcome with hybrid robot-assisted IA or recently with totally robotic procedures. In the literature, few works have been published comparing laparoscopic, hybrid, and totally robotic right colectomies. The aim of this study is to retrospectively analyze the improvements brought on by the evolution of robotic surgery at our specialized center., Materials and Methods: Two hundred six (hybrid and totally) robotic right colectomies (RRCs) with IA were compared with 160 laparoscopic right colectomies (LRCs) with EA. A separate analysis carried out by the robotic group compared 30 totally robotic right colectomies (TRRCs) with 176 hybrid robot-assisted right colectomies (HRRCs). Demographics, pathological features, operative details, and postoperative outcomes were retrospectively analyzed from a prospectively maintained database., Results: The groups were comparable with respect to demographics and tumor staging. When compared with LRC, RRC showed shorter time to first flatus (P < .001), stools (P < .001), solid diet (P < .001), and discharge (P < .001). The number of lymph nodes harvested was 23.13 ± 11.2 in RRC versus 20.5 ± 11.2 in LRC (P = .031). Operative time was longer in RRC (253.0 ± 47 minutes versus 209.9 ± 64 minutes; P < .001), but conversion to open (2.4% versus 18.1%; P < .001), anastomotic leaks (0.5% versus 5%; P = .012), and bleeding (0.3% versus 4.4%; P = .024) were significantly less frequent. Subsequent analysis shows no significant increase in operative time in TRRC versus HRRC (261.0 ± 41 minutes versus 251.6 ± 47.6 minutes; P = .310). Even if not statistically significant, TRRC showed faster bowel function recovery and tolerance to solid diet., Conclusions: We confirmed the clinical advantages of RRC with IA over LRC with EA in postoperative recovery outcomes and complication rate. Furthermore, our preliminary analysis in a cohort of 30 TRRC shows promising results.
- Published
- 2018
- Full Text
- View/download PDF
20. The Role of Laparoscopy in the Treatment of Anastomotic Leaks After Minimally Invasive Colorectal Resections for Cancer.
- Author
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Cimitan A, Contardo T, Molaro R, and Morpurgo E
- Subjects
- Aged, Aged, 80 and over, Anastomotic Leak surgery, Colectomy methods, Colostomy methods, Female, Humans, Male, Middle Aged, Postoperative Complications etiology, Prospective Studies, Reoperation, Time-to-Treatment, Video-Assisted Surgery methods, Colorectal Neoplasms surgery, Laparoscopy methods
- Abstract
Aim of the Study: The aim of this study was to describe the role of laparoscopy in the treatment of leaks occurring after minimally invasive colorectal resections., Materials and Methods: Thirty-four of 566 consecutive patients who underwent minimally invasive colorectal resection for cancer between January 2004 and December 2012 and who showed signs of anastomotic leakage (6%) requiring reoperation were studied using a prospectively maintained database. Patient characteristics, clinical signs, the surgical approach, the role of laparoscopy, operative and postoperative results, and the rate of permanent stoma were analyzed., Results: The median time to diagnosis of an anastomotic leak after surgery was 5.5 days. The median time to reoperation from the diagnosis of leakage was 2 days. Leaks were treated laparoscopically in 21 of 34 (61.8%) patients. Anastomoses were dismantled in 14 patients (41.2%) and the procedure was performed laparoscopically in 28.6% of the cases. The postoperative morbidity was 55.9%, the perioperative mortality 5.7%, and the rate of permanent stoma was 8.8%., Conclusions: Laparoscopic reoperation can be performed in most cases of anastomotic leaks occurring after minimally invasive colorectal resection for cancer. Anastomosis can be dismantled laparoscopically in 28.6% of the cases. A permanent stoma was necessary only in patients with terminal stomas.
- Published
- 2016
- Full Text
- View/download PDF
21. Robotic-assisted intracorporeal anastomosis versus extracorporeal anastomosis in laparoscopic right hemicolectomy for cancer: a case control study.
- Author
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Morpurgo E, Contardo T, Molaro R, Zerbinati A, Orsini C, and D'Annibale A
- Subjects
- Aged, Anastomosis, Surgical methods, Case-Control Studies, Colon, Ascending, Female, Humans, Male, Adenocarcinoma surgery, Colectomy methods, Colon surgery, Colonic Neoplasms surgery, Ileum surgery, Laparoscopy, Robotics
- Abstract
Introduction: Extracorporeal ileocolic anastomosis in laparoscopic right hemicolectomy for cancer has a significant risk of complications. The aim of this study is to evaluate the operative and postoperative results of hybrid right hemicolectomy with intracorporeal robotic-assisted anastomosis for adenocarcinoma of the ascending colon compared with the standard extracorporeal anastomosis in a case control study., Patients and Methods: Forty-eight right hemicolectomies for cancer (2009-2012) with laparoscopic medial to lateral dissection, vascular ligation, bowel transection, and robotic-assisted intracorporeal anastomosis with specimen extraction through a Pfannestiel incision (robotic group [RG]) were compared with 48 laparoscopic hemicolectomies (2009-2011) with extracorporeal anastomosis (laparoscopic group [LG])., Results: The two groups were comparable with respect to age, gender, stage of cancer, and body mass index. Surgery time was significantly longer in RG patients (RG, 266±41 minutes; LG, 223±51 minutes; P<.05). Operative results were similar in the two groups. Recovery of bowel function (day of first bowel movement: RG, 3.0±1.0 days; LG, 4.0±1.2 days; P<.05) and hospital stay (RG, 7.5±2.0 days; LG, 9.0±3.2 days; P<.05) were quicker and shorter, respectively, in RG. There were four anastomotic complications and four incisional hernias in LG and none in RG (P<.05)., Conclusions: There are fewer anastomotic and wound complications in RG patients. Intracorporeal robotic-assisted ileocolic anastomosis allows a faster recovery compared with extracorporeal anastomosis.
- Published
- 2013
- Full Text
- View/download PDF
22. Full robotic gastrectomy with extended (D2) lymphadenectomy for gastric cancer: surgical technique and preliminary results.
- Author
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D'Annibale A, Pende V, Pernazza G, Monsellato I, Mazzocchi P, Lucandri G, Morpurgo E, Contardo T, and Sovernigo G
- Subjects
- Aged, Blood Loss, Surgical, Databases, Factual, Disease-Free Survival, Female, Follow-Up Studies, Gastrectomy instrumentation, Humans, Laparoscopy instrumentation, Laparoscopy methods, Lymph Node Excision instrumentation, Male, Middle Aged, Minimally Invasive Surgical Procedures instrumentation, Minimally Invasive Surgical Procedures methods, Pilot Projects, Tissue and Organ Harvesting methods, Adenocarcinoma surgery, Gastrectomy methods, Lymph Node Excision methods, Robotics methods, Stomach Neoplasms surgery
- Abstract
Background: Widespread diffusion of minimally-invasive surgery for gastric cancer treatment is limited by the complexity of performing an extended D2-lymphadenectomy. This surgical step can be facilitated by using robot-assisted surgery. The aim of this study is to describe our technique and short-term results of a consecutive series of full robotic gastrectomies with D2-lymphadenectomy for gastric cancer, using the da Vinci Surgical System., Materials and Methods: Between May 2004 and December 2009, we performed 24 consecutive full robot-assisted total and subtotal gastrectomies with extended D2-lymphadenectomy for histologically-proven gastric adenocarcinoma. Data referring to 11 robot-assisted total gastrectomies and 13 subtotal gastrectomies were collected in a database and analyzed., Results: Median operative time was 267.50 min (255-305). Median intraoperative blood loss was 30 mL. Median number of harvested lymph nodes was 28 (23-34). Resection margins were negative in all cases. No conversions occurred. Surgery-related morbidity was 8%. Thirty-day mortality was 0%. Liquid diet started on postoperative d 5 (2-5). Median length of stay was 6 d (5-8)., Conclusions: Robot-assisted gastrectomy with D2-lymphadenectomy is a safe technique and allows achieving an adequate lymph node harvest and optimal R0-resection rates with low postoperative morbidity and the learning curve appears to be shorter than in laparoscopic surgery. Longer follow-up and randomized clinical trials are needed to define the role of robot-assistance in gastric cancer surgery., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
23. [Retroperitoneal and mesenteric fibrosis. An uncommon "carcinoid syndrome"].
- Author
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Spivach A, Sartori A, Martinolli S, Contardo T, and Zanconati F
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoid Tumor drug therapy, Carcinoid Tumor pathology, Carcinoid Tumor surgery, Humans, Ileal Neoplasms pathology, Male, Malignant Carcinoid Syndrome complications, Middle Aged, Peritoneal Diseases pathology, Peritoneal Diseases surgery, Retroperitoneal Fibrosis pathology, Retroperitoneal Fibrosis surgery, Treatment Outcome, Carcinoid Tumor complications, Ileal Neoplasms complications, Mesentery pathology, Peritoneal Diseases etiology, Retroperitoneal Fibrosis etiology
- Abstract
Retroperitoneal fibrosis is an uncommon disease in which dense fibrous tissue proliferates in the retroperitoneum. It frequently consists in an abdominal mass involving alimentary structures, ureters with obstruction, and vascular elements with stenosis. This pathological event may be associated with a history of ergotamine usage or a wide range of conditions including malignancy, injuries and infections. In the case described here, the cause was a midgut carcinoid tumour, releasing high concentrations of serotonin and other metabolites directly into the peritoneal fluid. Because carcinoid tumours of the bowel can remain silent for many years it is possible that similar cases of retroperitoneal fibrosis may be identified only many years after onset. For that reason, a long history of bowel obstruction must be considered a kind of unusual but no less important carcinoid syndrome.
- Published
- 2007
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