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2. Patients with cancer who will be cured and projections of complete prevalence in Italy from 2018 to 2030

Author

Crocetti, Emanuele, Mallone, Sandra, Pierannunzio, Daniela, Contiero, Paolo, Tagliabue, Giovanna, Memo, Laura, Manneschi, Gianfranco, Ravaioli, Alessandra, Cuccaro, Francesco, Richiardi, Lorenzo, Casella, Claudia, Anna di Prima, Alessia, Maifredi, Giovanni, Lanzoni, Monica, Cirilli, Claudia, Leite, Silvia, Michiara, Maria, Ferraioli, Serena, Zarcone, Maurizio, Vitale, Maria Francesca, Giacomazzi, Erica, Ghisleni, Silvia, Bisceglia, Isabella, Gentilini, Maria A., Vittadello, Fabio, Spata, Eugenia, Marguati, Stefano, Del Riccio, Luciana, Concas, Elisa, Sessa, Alessandra, Colanino, Antonino Ziino, Prazzoli, Rita, Ferrari, Gianfabrizio, Canu, Luisa, Guzzinati, S., Toffolutti, F., Francisci, S., De Paoli, A., Giudici, F., De Angelis, R., Demuru, E., Botta, L., Tavilla, A., Gatta, G., Capocaccia, R., Zorzi, M., Caldarella, A., Bidoli, E., Falcini, F., Bruni, R., Migliore, E., Puppo, A., Ferrante, M., Gasparotti, C., Gambino, M.L., Carrozzi, G., Bianconi, F., Musolino, A., Cavallo, R., Mazzucco, W., Fusco, M., Ballotari, P., Sampietro, G., Ferretti, S., Mangone, L., Mantovani, W., Mian, M., Cascone, G., Manzoni, F., Galasso, R., Piras, D., Pesce, M.T., Bella, F., Seghini, P., Fanetti, A.C., Pinna, P., Serraino, D., Rossi, S., and Dal Maso, L.

Published
2024
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3. Emerging Non-Breast Implant-Associated Lymphomas: A Systematic Review.

Author

Di Napoli, Arianna, Fruscione, Santo, Mazzola, Sergio, Amodio, Rosalba, Graziano, Giorgio, Mannino, Rita, Zarcone, Maurizio, Bertolazzi, Giorgio, Bonaccorso, Nicole, Sciortino, Martina, De Bella, Daniele Domenico, Savatteri, Alessandra, Belluzzo, Miriam, Norrito, Chiara Alba, Sparacino, Rosario, Contiero, Paolo, Tagliabue, Giovanna, Costantino, Claudio, and Mazzucco, Walter

Subjects
PROSTHETICS, MEDICAL information storage & retrieval systems, T-test (Statistics), RESEARCH funding, ANAPLASTIC large-cell lymphoma, FISHER exact test, PROBABILITY theory, ARTIFICIAL implants, LYMPHOMAS, SYSTEMATIC reviews, MEDLINE, CAUSALITY (Physics), ONLINE information services, B cell lymphoma
Abstract

Simple Summary: Prostheses are highly beneficial as they reduce the need for formal healthcare and support services, but they are not without side effects. Despite advancements, issues such as implant rejection and perioperative complications persist, and new concerns have arisen, including the potential link between long-term prosthetic use and cancer, specifically lymphoma. While the overall risk of developing lymphoma from prosthetic implants remains low, it is essential to explore the factors contributing to this risk. This highlights the need for ongoing research into the safety and long-term effects of prosthetic devices. Based on this evidence, we conducted a descriptive analysis using individual patient data from primary studies to investigate the relationship between lymphomas and different types of prosthetic devices, excluding breast implants. Background: Medical devices used for functional or esthetic purposes improve health and quality of life; however, they are not risk-free. Anaplastic large-cell lymphoma (ALCL), associated with breast implants, is a well-known and recognized distinct lymphoma entity. More recently, additional lymphomas have been reported in relation to prosthesis other than breast implants, as these allow the pericyte to develop into a clone that undergoes a maturation process, progressing toward full malignancy. Methods: We performed a systematic review with a descriptive analysis of data extracted from primary studies following PRISMA guidelines, including the search string "(IMPLANT* OR PROSTHES*) AND LYMPHOM*" in the PubMed, Scopus, Embase, and Google-Scholar databases. Data such as patient sex, age, implant site, prosthesis material, and lymphoma type were analyzed. Statistical methods, including Student's t-test and Fisher's exact test, were employed to compare lymphoma characteristics, with significance set at a p-value < 0.05. Results: From a total of 5992 studies, we obtained 43 case reports and series on a total of 52 patients diagnosed with prosthesis-associated lymphomas. The majority of implant-related lymphoma cases (85%) were of the B-cell type, mostly fibrin-associated large B-cell lymphoma (LBCL). This lymphoma type was more associated with biological (non-human-derived biological tissue), metallic, and synthetic implants (synthesized from non-organic components) (p-value = 0.007). Patients with ALCL had equal frequencies of metal and silicone prostheses (37.5%, 3 cases each), followed by synthetic prostheses (25%, 2 cases). ALCL cases were most common at skeletal (50%) and muscular-cutaneous sites (25%), whereas B-cell lymphomas were predominantly found in cardiovascular implants (50%), followed by skeletal (27%) and muscular-cutaneous (21%) sites. Death attributed to lymphoma took place in 67% of the cases, mostly LBCL occurring in cardiovascular sites. Conclusions: Because the included studies were limited to case reports and series, a potential non-causal link might have been documented between different implant materials, implant sites and lymphoma types. This underscores the importance of further comprehensive research and monitoring of non-breast implants. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Water and Soil Pollution: Ecological Environmental Study Methodologies Useful for Public Health Projects. A Literature Review

Author

Lillini, Roberto, Tittarelli, Andrea, Bertoldi, Martina, Ritchie, David, Katalinic, Alexander, Pritzkuleit, Ron, Launoy, Guy, Launay, Ludivine, Guillaume, Elodie, Žagar, Tina, Modonesi, Carlo, Meneghini, Elisabetta, Amati, Camilla, Di Salvo, Francesca, Contiero, Paolo, Borgini, Alessandro, Baili, Paolo, de Voogt, Pim, Series Editor, Cavieres, María Fernanda, Associate Editor, Knaak, James B., Associate Editor, van Wezel, Annemarie P., Associate Editor, Tjeerdema, Ronald S., Associate Editor, and Vighi, Marco, Associate Editor

Published
2021
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5. Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study

Author

Politis, Maria D., Bermejo-Sánchez, Eva, Canfield, Mark A., Contiero, Paolo, Cragan, Janet D., Dastgiri, Saeed, de Walle, Hermien E.K., Feldkamp, Marcia L., Nance, Amy, Groisman, Boris, Gatt, Miriam, Benavides-Lara, Adriana, Hurtado-Villa, Paula, Kallén, Kärin, Landau, Danielle, Lelong, Nathalie, Lopez-Camelo, Jorge, Martinez, Laura, Morgan, Margery, Mutchinick, Osvaldo M., Pierini, Anna, Rissmann, Anke, Šípek, Antonin, Szabova, Elena, Wertelecki, Wladimir, Zarante, Ignacio, Bakker, Marian K., Kancherla, Vijaya, Mastroiacovo, Pierpaolo, and Nembhard, Wendy N.

Published
2021
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6. Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study

Author

Jansana, Anna, primary, Auguste, Aviane, additional, Kvaskoff, Marina, additional, Fournier, Agnès, additional, Fontvieille, Emma, additional, Peruchet‐Noray, Laia, additional, Biessy, Carine, additional, Cordova, Reynalda, additional, Nielsen Petersen, Kristina Elin, additional, Tjønneland, Anne, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Ricceri, Fulvio, additional, Panico, Salvatore, additional, Contiero, Paolo, additional, Sánchez, Maria‐Jose, additional, Castilla, Jesus, additional, Crous‐Bou, Marta, additional, Heath, Alicia, additional, Aglago, Elom Kouassivi, additional, Weiderpass, Elisabete, additional, Gunter, Marc James, additional, Ferrari, Pietro, additional, Riboli, Elio, additional, Viallon, Vivian, additional, and Freisling, Heinz, additional

Published
2024
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7. Impact of pre-existing cardiometabolic diseases on metastatic cancer stage at diagnosis:a prospective multinational cohort study

Author

Jansana, Anna, Auguste, Aviane, Kvaskoff, Marina, Fournier, Agnès, Fontvieille, Emma, Peruchet-Noray, Laia, Biessy, Carine, Cordova, Reynalda, Nielsen Petersen, Kristina Elin, Tjønneland, Anne, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Panico, Salvatore, Contiero, Paolo, Sánchez, Maria-Jose, Castilla, Jesus, Crous-Bou, Marta, Heath, Alicia, Aglago, Elom Kouassivi, Weiderpass, Elisabete, Gunter, Marc James, Ferrari, Pietro, Riboli, Elio, Viallon, Vivian, Freisling, Heinz, Jansana, Anna, Auguste, Aviane, Kvaskoff, Marina, Fournier, Agnès, Fontvieille, Emma, Peruchet-Noray, Laia, Biessy, Carine, Cordova, Reynalda, Nielsen Petersen, Kristina Elin, Tjønneland, Anne, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Panico, Salvatore, Contiero, Paolo, Sánchez, Maria-Jose, Castilla, Jesus, Crous-Bou, Marta, Heath, Alicia, Aglago, Elom Kouassivi, Weiderpass, Elisabete, Gunter, Marc James, Ferrari, Pietro, Riboli, Elio, Viallon, Vivian, and Freisling, Heinz

Abstract

Owing to shared risk factors between cardiometabolic diseases (CMDs) and cancer, coupled with population aging, the lifetime risk of an individual developing cancer after a CMD is increasing. Furthermore, biological mechanisms such as insulin resistance or inflammation may not only predispose individuals with CMD to an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage, Owing to shared risk factors between cardiometabolic diseases (CMDs) and cancer, coupled with population aging, the lifetime risk of an individual developing cancer after a CMD is increasing. Furthermore, biological mechanisms such as insulin resistance or inflammation may not only predispose individuals with CMD to an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage

Published
2024

8. Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980–2010

Author

Yu, Xiao, Nassar, Natasha, Mastroiacovo, Pierpaolo, Canfield, Mark, Groisman, Boris, Bermejo-Sánchez, Eva, Ritvanen, Annukka, Kiuru-Kuhlefelt, Sonja, Benavides, Adriana, Sipek, Antonin, Pierini, Anna, Bianchi, Fabrizio, Källén, Karin, Gatt, Miriam, Morgan, Margery, Tucker, David, Canessa, M. Aaurora, Gajardo, Rosa, Mutchinick, Osvaldo M., Szabova, Elena, Csáky-Szunyogh, Melinda, Tagliabue, Giovanna, Cragan, Janet D., Nembhard, Wendy N., Rissmann, Anke, Goetz, Dorit, Bower, Carol, Baynam, Gareth, Lowry, R. Brian, Leon, Juan A., Luo, Wei, Rouleau, Jocelyn, Zarante, Ignacio, Fernandez, Nicolas, Amar, Emmanuelle, Dastgiri, Saeed, Contiero, Paolo, Martínez-de-Villarreal, Laura E., Borman, Barry, Bergman, J.E.H., de Walle, Hermien E.K., Hobbs, Charlotte A., Nance, Amy E., and Agopian, A.J.

Published
2019
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9. The Impact of Russia-Ukraine geopolitical conflict on the air quality and toxicological properties of ambient PM2.5 in Milan, Italy.

Author

Aghaei, Yashar, primary, Badami, Mohammad Mahdi, additional, Tohidi, Ramin, additional, Sioutas, Constantinos, additional, Subramanian, Ganesh, additional, Verma, Vishal, additional, Boffi, Roberto, additional, Borgini, Alessandro, additional, De Marco, Cinzia, additional, Contiero, Paolo, additional, Ruprecht, Ario Alberto, additional, and Chatila, Talal, additional

Published
2023
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10. Implant replacement and anaplastic large cell lymphoma associated with breast implants: a quantitative analysis

Author

Vittorietti, Martina, primary, Mazzola, Sergio, additional, Costantino, Claudio, additional, De Bella, Daniele Domenico, additional, Fruscione, Santo, additional, Bonaccorso, Nicole, additional, Sciortino, Martina, additional, Costanza, Davide, additional, Belluzzo, Miriam, additional, Savatteri, Alessandra, additional, Tramuto, Fabio, additional, Contiero, Paolo, additional, Tagliabue, Giovanna, additional, Immordino, Palmira, additional, Vitale, Francesco, additional, Di Napoli, Arianna, additional, and Mazzucco, Walter, additional

Published
2023
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11. The Impact of Russia-Ukraine geopolitical conflict on the air quality and toxicological properties of ambient PM2.5 in Milan, Italy.

Author

Aghaei, Yashar, Badami, Mohammad Mahdi, Tohidi, Ramin, Subramanian, P. S. Ganesh, Boffi, Roberto, Borgini, Alessandro, De Marco, Cinzia, Contiero, Paolo, Ruprecht, Ario Alberto, Verma, Vishal, Chatila, Talal, and Sioutas, Constantinos

Subjects
RUSSIA-Ukraine Conflict, 2014-, RUSSIAN invasion of Ukraine, 2022-, NATURAL gas reserves, BIOMASS burning, PARTICULATE matter
Abstract

The geopolitical conflict between Russia and Ukraine has disrupted Europe's natural gas supplies, driving up gas prices and leading to a shift towards biomass for residential heating during colder months. This study assessed the consequent air quality and toxicological impacts in Milan, Italy, focusing on fine particulate matter (PM2.5, dp < 2.5 μm) emissions. PM2.5 samples were analyzed for their chemical composition and assessed for their oxidative potential using the dithiothreitol (DTT) assay across three periods reflecting residential heating deployment (RHD): pre-RHD, intra-RHD, and post-RHD periods. During the intra-RHD period, PM2.5 levels were significantly higher than those in other periods, with concentrations reaching 57.94 ± 7.57 μg/m3, indicating a deterioration in air quality. Moreover, levoglucosan was 9.2 times higher during the intra-RHD period compared to the pre-RHD period, correlating with elevated levels of elemental carbon (EC) and polycyclic aromatic hydrocarbons (PAHs). These findings were compared with previous local studies before the conflict, underscoring a significant rise in biomass-related emissions. DTT assay levels during the intra-RHD were 2.1 times higher than those observed during the same period in 2022, strongly correlating with biomass burning emissions. Our findings highlight the necessity for policies to mitigate the indirect health effects of increased biomass burning emissions due to the energy crisis triggered by the geopolitical conflict. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Analysis of early neonatal case fatality rate among newborns with congenital hydrocephalus, a 2000-2014 multi-country registry-based study

Author

Gili, Juan Antonio, López-Camelo, Jorge Santiago, Nembhard, Wendy N, Bakker, Marian, de Walle, Hermien E K, Stallings, Erin B, Kancherla, Vijaya, Contiero, Paolo, Dastgiri, Saeed, Feldkamp, Marcia L, Nance, Amy, Gatt, Miriam, Martínez, Laura, Canessa, María Aurora, Groisman, Boris, Hurtado-Villa, Paula, Källén, Karin, Landau, Danielle, Lelong, Nathalie, Morgan, Margery, Arteaga-Vázquez, Jazmín, Pierini, Anna, Rissmann, Anke, Sipek, Antonin, Szabova, Elena, Wertelecki, Wladimir, Zarante, Ignacio, Canfield, Mark A, Mastroiacovo, Pierpaolo, and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
Embryology, Health, Toxicology and Mutagenesis, Infant, Newborn, Stillbirth, Toxicology, Article, Pregnancy, Pediatrics, Perinatology and Child Health, Prevalence, Humans, Female, Registries, Live Birth, Hydrocephalus, Developmental Biology
Abstract

BACKGROUND: Congenital hydrocephalus (CH) comprises a heterogeneous group of birth anomalies with a wide-ranging prevalence across geographic regions and registry type. The aim of the present study was to analyze the early neonatal case fatality rate (CFR) and total birth prevalence of newborns diagnosed with CH.METHODS: Data were provided by 25 registries from four continents participating in the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) on births ascertained between 2000 and 2014. Two CH rates were calculated using a Poisson distribution: early neonatal CFR (death within 7 days) per 100 liveborn CH cases (CFR) and total birth prevalence rate (BPR) per 10,000 births (including live births and stillbirths) (BPR). Heterogeneity between registries was calculated using a meta-analysis approach with random effects. Temporal trends in CFR and BPR within registries were evaluated through Poisson regression modeling.RESULTS: A total of 13,112 CH cases among 19,293,280 total births were analyzed. The early neonatal CFR was 5.9 per 100 liveborn cases, 95% confidence interval (CI): 5.4-6.8. The CFR among syndromic cases was 2.7 times (95% CI: 2.2-3.3) higher than among non-syndromic cases (10.4% [95% CI: 9.3-11.7] and 4.4% [95% CI: 3.7-5.2], respectively). The total BPR was 6.8 per 10,000 births (95% CI: 6.7-6.9). Stratified by elective termination of pregnancy for fetal anomalies (ETOPFA), region and system, higher CFR were observed alongside higher BPR rates. The early neonatal CFR and total BPR did not show temporal variation, with the exception of a CFR decrease in one registry.CONCLUSIONS: Findings of early neonatal CFR and total BPR were highly heterogeneous among registries participating in ICBDSR. Most registries with higher CFR also had higher BPR. Differences were attributable to type of registry (hospital-based vs. population-based), ETOPFA (allowed yes or no) and geographical regions. These findings contribute to the understanding of regional differences of CH occurrence and early neonatal deaths.

Published
2022

14. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

Heath, Alicia K., Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna

Published
2020
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15. Changes in lifestyle and risk of colorectal cancer in the european prospective investigation into cancer and nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro

Abstract

Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. Methods: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI). Results: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile. Discussion: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.

Published
2023
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16. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Author

Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro

Published
2023

17. Causes of death in women with breast cancer: a risks and rates study on a population-based cohort.

Author

Contiero, Paolo, Boffi, Roberto, Borgini, Alessandro, Fabiano, Sabrina, Tittarelli, Andrea, Mian, Michael, Vittadello, Fabio, Epifani, Susi, Ardizzone, Antonino, Cirilli, Claudia, Boschetti, Lorenza, Marguati, Stefano, Cascone, Giuseppe, Tumino, Rosario, Fanetti, Anna Clara, Giumelli, Paola, Candela, Giuseppa, Scuderi, Tiziana, Castelli, Maurizio, and Bongiorno, Salvatore

Subjects
CANCER patients, CAUSES of death, DISEASE risk factors, CARDIOVASCULAR diseases, BREAST cancer, COHORT analysis
Abstract

Introduction: The increasing survival of patients with breast cancer has prompted the assessment of mortality due to all causes of death in these patients. We estimated the absolute risks of death from different causes, useful for health-care planning and clinical prediction, as well as cause-specific hazards, useful for hypothesis generation on etiology and risk factors. Materials and methods: Using data from population-based cancer registries we performed a retrospective study on a cohort of women diagnosed with primary breast cancer. We carried out a competing-cause analysis computing cumulative incidence functions (CIFs) and cause-specific hazards (CSHs) in the whole cohort, separately by age, stage and registry area. Results: The study cohort comprised 12,742 women followed up for six years. Breast cancer showed the highest CIF, 13.71%, and cardiovascular disease was the second leading cause of death with a CIF of 3.60%. The contribution of breast cancer deaths to the CIF for all causes varied widely by age class: 89.25% in women diagnosed at age <50 years, 72.94% in women diagnosed at age 50-69 and 48.25% in women diagnosed at age =70. Greater CIF variations were observed according to stage: the contribution of causes other than breast cancer to CIF for all causes was 73.4% in women with stage I disease, 42.9% in stage II-III and only 13.2% in stage IV. CSH computation revealed temporal variations: in women diagnosed at age =70 the CSH for breast cancer was equaled by that for cardiovascular disease and "other diseases" in the sixth year following diagnosis, and an early peak for breast cancer was identified in the first year following diagnosis. Among women aged 50-69 we identified an early peak for breast cancer followed by a further peak near the second year of follow-up. Comparison by geographic area highlighted conspicuous variations: the highest CIF for cardiovascular disease was more than 70% higher than the lowest, while for breast cancer the highest CIF doubled the lowest. Conclusion: The integrated interpretation of absolute risks and hazards suggests the need for multidisciplinary surveillance and prevention using communitybased, holistic and well-coordinated survivorship care models. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Table S5 from Tau Mutations Serve as a Novel Risk Factor for Cancer

Author

Rossi, Giacomina, primary, Redaelli, Veronica, primary, Contiero, Paolo, primary, Fabiano, Sabrina, primary, Tagliabue, Giovanna, primary, Perego, Paola, primary, Benussi, Luisa, primary, Bruni, Amalia C., primary, Filippini, Graziella, primary, Farinotti, Mariangela, primary, Giaccone, Giorgio, primary, Buiatiotis, Simona, primary, Manzoni, Claudia, primary, Ferrari, Raffaele, primary, and Tagliavini, Fabrizio, primary

Published
2023
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20. Data from Tau Mutations Serve as a Novel Risk Factor for Cancer

Author

Rossi, Giacomina, primary, Redaelli, Veronica, primary, Contiero, Paolo, primary, Fabiano, Sabrina, primary, Tagliabue, Giovanna, primary, Perego, Paola, primary, Benussi, Luisa, primary, Bruni, Amalia C., primary, Filippini, Graziella, primary, Farinotti, Mariangela, primary, Giaccone, Giorgio, primary, Buiatiotis, Simona, primary, Manzoni, Claudia, primary, Ferrari, Raffaele, primary, and Tagliavini, Fabrizio, primary

Published
2023
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22. Out-of-pocket costs for cancer survivors between 5 and 10 years from diagnosis: an Italian population-based study

Author

Baili, Paolo, Di Salvo, Francesca, de Lorenzo, Francesco, Maietta, Francesco, Pinto, Carmine, Rizzotto, Vera, Vicentini, Massimo, Rossi, Paolo Giorgi, Tumino, Rosario, Rollo, Patrizia Concetta, Tagliabue, Giovanna, Contiero, Paolo, Candela, Pina, Scuderi, Tiziana, Iannelli, Elisabetta, Cascinu, Stefano, Aurora, Fulvio, Agresti, Roberto, Turco, Alberto, Sant, Milena, Meneghini, Elisabetta, and Micheli, Andrea

Published
2016
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23. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Author

Botteri, Edoardo, primary, Peveri, Giulia, additional, Berstad, Paula, additional, Bagnardi, Vincenzo, additional, Chen, Sairah L.F., additional, Sandanger, Torkjel M., additional, Hoff, Geir, additional, Dahm, Christina C., additional, Antoniussen, Christian S., additional, Tjønneland, Anne, additional, Eriksen, Anne Kirstine, additional, Skeie, Guri, additional, Perez-Cornago, Aurora, additional, Huerta, José María, additional, Jakszyn, Paula, additional, Harlid, Sophia, additional, Sundström, Björn, additional, Barricarte, Aurelio, additional, Monninkhof, Evelyn M., additional, Derksen, Jeroen W.G., additional, Schulze, Matthias B., additional, Bueno-de-Mesquita, Bas, additional, Sánchez, Maria-Jose, additional, Cross, Amanda J., additional, Tsilidis, Konstantinos K., additional, De Magistris, Maria Santucci, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Rothwell, Joseph A., additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Amiano, Pilar, additional, Contiero, Paolo, additional, Sacerdote, Carlotta, additional, Goldberg, Marcel, additional, Touvier, Mathilde, additional, Freisling, Heinz, additional, Viallon, Vivian, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Gunter, Marc J., additional, Jenab, Mazda, additional, and Ferrari, Pietro, additional

Published
2022
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24. Comparison between two cancer registry quality check systems: functional features and differences in an Italian network of cancer registries dataset.

Author

Tagliabue, Giovanna, Perotti, Viviana, Fabiano, Sabrina, Tittarelli, Andrea, Barigelletti, Giulio, Contiero, Paolo, Mazzucco, Walter, Fusco, Mario, Bidoli, Ettore, Vicentini, Massimo, Pesce, Maria Teresa, and Stracci, Fabrizio

Subjects
TUMOR grading, DATA quality, QUALITY control, TUMOR classification, TUMOR diagnosis
Abstract

Purpose: The aim of this study was to compare the functional characteristics of two computer-based systems for quality control of cancer registry data through analysis of their output differences. Methods: The study used cancer incidence data from 22 of the 49 registries of the Italian Network of Cancer Registries registered between 1986 and 2017. Two different data checking systems developed by the WHO International Agency for Research on Cancer (IARC) and the Joint Research Center (JRC) with the European Network of Cancer Registries (ENCR) and routinely used by registrars were used to check the quality of the data. The outputs generated by the two systems on the same dataset of each registry were analyzed and compared. Results: The study included a total of 1,305,689 cancer cases. The overall quality of the dataset was high, with 86% (81.7-94.1) microscopically verified cases and only 1.3% (0.03-3.06) cases with a diagnosis by death certificate only. The two check systems identified a low percentage of errors (JRC-ENCR 0.17% and IARC 0.003%) and about the same proportion of warnings (JRC-ENCR 2.79% and IARC 2.42%) in the dataset. Forty-two cases (2% of errors) and 7067 cases (11.5% of warnings) were identified by both systems in equivalent categories. 11.7% of warnings related to TNM staging were identified by the JRC-ENCR system only. The IARC system identified mainly incorrect combination of tumor grade and morphology (72.5% of warnings). Conclusion: Both systems apply checks on a common set of variables, but some variables are checked by only one of the systems (for example, checks on patient follow-up and tumor stage at diagnosis are included by the JRC-ENCR system only). Most errors and warnings were categorized differently by the two systems, but usually described the same issues, with warnings related to "morphology" (JRC-ENCR) and "histology" (IARC) being the most frequent. It is important to find the right balance between the need to maintain high standards of data quality and the workability of such systems in the daily routine of the cancer registry. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Ssenyonga, Naomi, primary, Stiller, Charles, additional, Nakata, Kayo, additional, Shalkow, Jaime, additional, Redmond, Shelagh, additional, Bulliard, Jean-Luc, additional, Girardi, Fabio, additional, Fowler, Christine, additional, Marcos-Gragera, Rafael, additional, Bonaventure, Audrey, additional, Saint-Jacques, Nathalie, additional, Minicozzi, Pamela, additional, De, Prithwish, additional, Rodríguez-Barranco, Miguel, additional, Larønningen, Siri, additional, Di Carlo, Veronica, additional, Mägi, Margit, additional, Valkov, Mikhail, additional, Seppä, Karri, additional, Wyn Huws, Dyfed, additional, Coleman, Michel P, additional, Allemani, Claudia, additional, Bouzbid, Sabiha, additional, Hamdi-Chérif, Mokhtar, additional, Kara, Lamia, additional, Meguenni, Kaouel, additional, Regagba, Derbali, additional, Bayo, Sine, additional, Cheick Bougadari, Traore, additional, Manraj, Shyam Shunker, additional, Bendahhou, Karima, additional, Ladipo, Akinade, additional, Ogunbiyi, Olufemi, additional, Somdyala, Nontuthuzelo, additional, Chaplin, María Agustina, additional, Moreno, Florencia, additional, Calabrano, Gladis, additional, Espinola, Silvia, additional, Carballo Quintero, Beatriz, additional, Fita, Rosalba, additional, Laspada, Walter, additional, Ibañez, Susana, additional, Lima, Carlos, additional, Mafra Da Costa, Allini, additional, De Souza, Paulo César, additional, Chaves, Juliana, additional, Laporte, Cyntia, additional, Curado, Maria Paula, additional, de Oliveira, Jose Carlos, additional, Veneziano, Claudia, additional, Veneziano, Donaldo, additional, Almeida, Ana Beatriz, additional, Latorre, Maria, additional, Azevedo e Silva, Gulnar, additional, Rebelo, Marise, additional, Santos, Marceli, additional, Galaz, Juan, additional, Aparicio Aravena, Mackarena, additional, Sanhueza Monsalve, Jocelyn, additional, Herrmann, Denise, additional, Vargas, Solange, additional, Herrera, Victor, additional, Uribe, Claudia, additional, Bravo, Luis Eduardo, additional, Garcia, Luz Stella, additional, Arias-Ortiz, Nelson, additional, Morantes, Daniela, additional, Jurado, Daniel, additional, Yépez Chamorro, María, additional, Delgado, Sandra, additional, Ramirez, Melissa, additional, Galán Alvarez, Yaima, additional, Torres, Priscila, additional, Martínez-Reyes, Fray, additional, Jaramillo, Leyda, additional, Quinto, Rina, additional, Castillo, Jhoanna, additional, Mendoza, Mariela, additional, Cueva, Patricia, additional, Yépez, José, additional, Bhakkan, Bernard, additional, Deloumeaux, Jacqueline, additional, Joachim, Clarisse, additional, Macni, Jonathan, additional, Carrillo, Rodolfo, additional, Shalkow Klincovstein, Jaime, additional, Rivera Gomez, Rebeca, additional, Perez, Patricia, additional, Poquioma, Ebert, additional, Tortolero-Luna, Guillermo, additional, Zavala, Diego, additional, Alonso, Rafael, additional, Barrios, Enrique, additional, Eckstrand, Angela, additional, Nikiforuk, Cindy, additional, Woods, Ryan, additional, Noonan, Gail, additional, Turner, Donna, additional, Kumar, Eshwar, additional, Zhang, Bin, additional, Dowden, Jeff, additional, Doyle, Gregory, additional, Walsh, Gordon, additional, Anam, Aniq, additional, McClure, Carol, additional, Vriends, Kim, additional, Bertrand, Christine, additional, Ramanakumar, Agnihotram, additional, Kozie, Serena, additional, Stuart-Panko, Heather, additional, Freeman, Tara, additional, George, Justin, additional, Avila, Rosa, additional, O'Brien, David, additional, Holt, Abby, additional, Almon, Lyn, additional, Ward, Kevin, additional, Kwong, Sandy, additional, Morris, Cyllene, additional, Rycroft, Randi, additional, Mueller, Lloyd, additional, Phillips, Cathryn, additional, Brown, Heather, additional, Cromartie, Betsy, additional, Ruterbusch, Julie, additional, Schwartz, Ann, additional, Levin, Gary, additional, Wohler, Brad, additional, Bayakly, Rana, additional, Gomez, Scarlett, additional, McKinley, Meg, additional, Cress, Rosemary, additional, Davis, Joni, additional, Hernandez, Brenda, additional, Johnson, Christopher, additional, Morawski, Bozena, additional, Ruppert, Laura, additional, Bentler, Suzanne, additional, Charlton, Mary, additional, Huang, Bin, additional, Tucker, Thomas, additional, Deapen, Dennis, additional, Liu, Lihua, additional, Hsieh, Mei-Chin, additional, Wu, Xiao-Cheng, additional, Schwenn, Molly, additional, Stern, Kimberly, additional, Gershman, Susan, additional, Knowlton, Richard, additional, Alverson, Georgetta, additional, Weaver, Tamara, additional, Desai, Jay, additional, Rogers, Deirdre, additional, Jackson-Thompson, Jeanette, additional, Lemons, Debbi, additional, Zimmerman, Heather, additional, Hood, Michelle, additional, Roberts-Johnson, Jenifer, additional, Hammond, Whitney, additional, Rees, Judith, additional, Pawlish, Karen, additional, Stroup, Antoinette, additional, Key, Charles, additional, Wiggins, Charles, additional, Kahn, Amy, additional, Schymura, Maria, additional, Radhakrishnan, Soundarya, additional, Rao, Chandrika, additional, Giljahn, Lynn, additional, Slocumb, Roberta, additional, Dabbs, Christy, additional, Espinoza, Raffaella, additional, Aird, Karen, additional, Beran, Todd, additional, Rubertone, Jim, additional, Slack, Stephen, additional, Oh, Junhie, additional, Janes, Tiffany, additional, Schwartz, Stephen, additional, Chiodini, Stephanie, additional, Hurley, Deborah, additional, Whiteside, Martin, additional, Rai, Saroj, additional, Williams, Melanie, additional, Herget, Kim, additional, Sweeney, Carol, additional, Johnson, Alison, additional, Keitheri Cheteri, Mahesh, additional, Migliore Santiago, Patti, additional, Blankenship, Steven, additional, Farley, Shawn, additional, Borchers, Robert, additional, Malicki, Robin, additional, Espinoza, Julia, additional, Grandpre, Joseph, additional, Edwards, Brenda, additional, Mariotto, Angela, additional, Weir, Hannah, additional, Wilson, Reda, additional, Wang, Ning, additional, Yang, Lei, additional, Chen, Jian-Shun, additional, He, Yu-Tong, additional, Song, Guo-Hui, additional, Gu, Xiao-Ping, additional, Mei, Dan, additional, Ge, Heng-Ming, additional, Wu, Tong-Hao, additional, Li, Yan-Yan, additional, Zhao, De-Li, additional, Jin, Feng, additional, Zhang, Jian-Hua, additional, Zhu, Feng-Dong, additional, Junhua, Qian, additional, Yang, Yan Lei, additional, Jiang, Chun-Xiao, additional, Biao, Wang, additional, Wang, Jian, additional, Li, Qi-Long, additional, Yi, He, additional, Zhou, Xin, additional, Dong, JianMei, additional, Li, WeiWei, additional, Fu, Fang-Xian, additional, Chen, Jian-Guo, additional, Zhu, Jian, additional, Li, Yan-Hua, additional, Lu, Yu-Qiang, additional, Fan, Min, additional, Huang, Su-Qin, additional, Guo, Guo-Ping, additional, Zhaolai, Hua, additional, Wei, Kuangrong, additional, Chen, Wan-Qing, additional, Wei, Wenqiang, additional, Zeng, Hongmei, additional, Demetriou, Anna, additional, Mang, Wai Kong, additional, Ngan, Kai Cheong, additional, Kataki, Amal, additional, Krishnatreya, Manigreeva, additional, Jayalekshmi, Padmavathi Amma, additional, Sebastian, Paul, additional, George, Preethi, additional, Mathew, Aleyamma, additional, Nandakumar, Ambakumar, additional, Malekzadeh, Reza, additional, Roshandel, Gholamreza, additional, Keinan-Boker, Lital, additional, Silverman, Barbara, additional, Ito, Hidemi, additional, Koyanagi, Yuriko, additional, Sato, Masako, additional, Tobori, Fumio, additional, Nakata, Ichiro, additional, Teramoto, Norihiro, additional, Hattori, Masakazu, additional, Kaizaki, Yasuharu, additional, Moki, Fumitaka, additional, Sugiyama, Hiromi, additional, Utada, Mai, additional, Nishimura, Makiko, additional, Yoshida, Keiichi, additional, Kurosawa, Katsuki, additional, Nemoto, Yuji, additional, Narimatsu, Hiroto, additional, Sakaguchi, Masahiko, additional, Kanemura, Seiki, additional, Naito, Michiko, additional, Narisawa, Rintaro, additional, Miyashiro, Isao, additional, Mori, Daisuke, additional, Yoshitake, Mayuko, additional, Oki, Izumi, additional, Fukushima, Norimasa, additional, Shibata, Akiko, additional, Iwasa, Keiichiro, additional, Ono, Chie, additional, Matsuda, Tomohiro, additional, Nimri, Omar, additional, Jung, Kyu-Won, additional, Won, Young-Joo, additional, Alawadhi, Eiman, additional, Elbasmi, Amani, additional, Ab Manan, Azizah, additional, Adam, Farzaana, additional, Nansalmaa, Erdenekhuu, additional, Tudev, Undarmaa, additional, Ochir, Chimedsuren, additional, Al Khater, Al Hareth, additional, El Mistiri, Mufid, additional, Lim, Gek Hsiang, additional, Teo, Yik Ying, additional, Chiang, Chun-Ju, additional, Lee, Wen-Chung, additional, Buasom, Rangsiya, additional, Sangrajrang, Suleeporn, additional, Suwanrungruang, Krittika, additional, Vatanasapt, Patravoot, additional, Daoprasert, Karnchana, additional, Pongnikorn, Donsuk, additional, Leklob, Atit, additional, Sangkitipaiboon, Somphob, additional, Geater, Sarayut, additional, Sriplung, Hutcha, additional, Ceylan, Okan, additional, Kög, Iskender, additional, Dirican, Oya, additional, Köse, Tülay, additional, Gurbuz, Tulın, additional, Karašahin, Füsun Emine, additional, Turhan, Duygu, additional, Aktaş, Umut, additional, Halat, Yakup, additional, Eser, Sultan, additional, Yakut, Cankut, additional, Altinisik, Merve, additional, Cavusoglu, Yasar, additional, Türkköylü, Ayşe, additional, Üçüncü, Nuršen, additional, Hackl, Monika, additional, Zborovskaya, Anna, additional, Aleinikova, Olga, additional, Henau, Kris, additional, Van Eycken, Liesbet, additional, Atanasov, Trayan, additional, Valerianova, Zdravka, additional, Šekerija, Mario, additional, Dušek, Ladislav, additional, Zvolský, Miroslav, additional, Steinrud Mørch, Lina, additional, Storm, Hans, additional, Wessel Skovlund, Charlotte, additional, Innos, Kaire, additional, Malila, Nea, additional, Jégu, Jérémie, additional, Velten, Michel, additional, Cornet, Edouard, additional, Troussard, Xavier, additional, Bouvier, Anne-Marie, additional, Guizard, Anne-Valérie, additional, Bouvier, Véronique, additional, Launoy, Guy, additional, Dabakuyo Yonli, Sandrine, additional, Poillot, Marie-Laure, additional, Maynadié, Marc, additional, Mounier, Morgane, additional, Vaconnet, Lina, additional, Woronoff, Anne-Sophie, additional, Daoulas, Mélanie, additional, Robaszkiewicz, Michel, additional, Clavel, Jacqueline, additional, Poulalhon, Claire, additional, Desandes, Emmanuel, additional, Lacour, Brigitte, additional, Baldi, Isabelle, additional, Pouchieu, Camille, additional, Amadeo, Brice, additional, Coureau, Gaëlle, additional, Monnereau, Alain, additional, Audoin, Magali, additional, D'Almeida, Tania, additional, Boyer, Séverine, additional, Hammas, Karima, additional, Trétarre, Brigitte, additional, Colonna, Marc, additional, Delafosse, Patricia, additional, Plouvier, Sandrine, additional, Cowppli-Bony, Anne, additional, Molinié, Florence, additional, Bara, Simona, additional, Ganry, Olivier, additional, Lapôtre-Ledoux, Bénédicte, additional, Daubisse-Marliac, Laetitia, additional, Bossard, Nadine, additional, Estève, Jacques, additional, Uhry, Zoé, additional, Stabenow, Roland, additional, Wilsdorf-Köhler, Heide, additional, Eberle, Andrea, additional, Luttmann, Sabine, additional, Löhden, Imma, additional, Nennecke, Alice, additional, Kieschke, Joachim, additional, Sirri, Eunice, additional, Justenhoven, Christina, additional, Zeissig, Sylke, additional, Holleczek, Bernd, additional, Eisemann, Nora, additional, Katalinic, Alexander, additional, Asquez, Rachelle, additional, Kumar, Vijay, additional, Petridou, Eleni, additional, Ólafsdóttir, Elínborg, additional, Tryggvadóttir, Laufey, additional, Murray, Deirdre, additional, Walsh, Paul, additional, Sundseth, Hildrun, additional, Mazzoleni, Guido, additional, Vittadello, Fabio, additional, Coviello, Enzo, additional, Cuccaro, Francesco, additional, Galasso, Rocco, additional, Sampietro, Giuseppe, additional, Magoni, Michele, additional, Ardizzone, Antonino, additional, D'Argenzio, Angelo, additional, Di Prima, Alessia Anna, additional, Ippolito, Antonella, additional, Lavecchia, Anna Maria, additional, Sutera Sardo, Antonella, additional, Gola, Gemma, additional, Ballotari, Paola, additional, Giacomazzi, Erica, additional, Ferretti, Stefano, additional, Dal Maso, Luigino, additional, Serraino, Diego, additional, Celesia, Maria Vittoria, additional, Filiberti, Rosa Angela, additional, Pannozzo, Fabio, additional, Melcarne, Anna, additional, Quarta, Fabrizio, additional, Andreano, Anita, additional, Russo, Antonio Giampiero, additional, Carrozzi, Giuliano, additional, Cirilli, Claudia, additional, Cavalieri d'Oro, Luca, additional, Rognoni, Magda, additional, Fusco, Mario, additional, Vitale, Maria Francesca, additional, Usala, Mario, additional, Cusimano, Rosanna, additional, Mazzucco, Walter, additional, Michiara, Maria, additional, Sgargi, Paolo, additional, Boschetti, Lorenza, additional, Chiaranda, Giorgio, additional, Seghini, Pietro, additional, Maule, Milena, additional, Merletti, Franco, additional, Spata, Eugenia, additional, Tumino, Rosario, additional, Mancuso, Pamela, additional, Vicentini, Massimo, additional, Cassetti, Tiziana, additional, Sassatelli, Romano, additional, Falcini, Fabio, additional, Giorgetti, Stefania, additional, Caiazzo, Anna Luisa, additional, Cavallo, Rossella, additional, Piras, Daniela, additional, Bella, Francesca, additional, Madeddu, Anselmo, additional, Fanetti, Anna Clara, additional, Maspero, Sergio, additional, Carone, Simona, additional, Mincuzzi, Antonia, additional, Candela, Giuseppa, additional, Scuderi, Tiziana, additional, Gentilini, Maria Adalgisa, additional, Rizzello, Roberto, additional, Rosso, Stefano, additional, Zanetti, Roberto, additional, Caldarella, Adele, additional, Intrieri, Teresa, additional, Bianconi, Fortunato, additional, Stracci, Fabrizio, additional, Contiero, Paolo, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Zorzi, Manuel, additional, Beggiato, Simonetta, additional, Brustolin, Angelita, additional, De Angelis, Roberta, additional, Gatta, Gemma, additional, Maurina, Anita, additional, Oniščuka, Marija, additional, Mousavi, Mohsen, additional, Lipunova, Nadezda, additional, Vincerzevskienė, Ieva, additional, Agius, Dominic, additional, Calleja, Neville, additional, Siesling, Sabine, additional, Visser, Otto, additional, Johannesen, Tom, additional, Trojanowski, Maciej, additional, Mierzwa, Tomasz, additional, Rachtan, Jadwiga, additional, Kępska, Kamila, additional, Kościańska, Beata, additional, Wójcik-Tomaszewska, Joanna, additional, Motnyk, Marcin, additional, Gos, Anna, additional, Bielska-Lasota, Magdalena, additional, Didkowska, Joanna, additional, Wojciechowska, Urszula, additional, Forjaz de Lacerda, Gonçalo, additional, Rego, Raul, additional, Carrito, Branca, additional, Pais, Ana, additional, Bento, Maria José, additional, Rodrigues, Jessica, additional, Lourenço, Antonio, additional, Mayer-da-Silva, Alexandra, additional, Blaga, Luminita, additional, Coza, Daniela, additional, Gusenkova, Lubov, additional, Lazarevich, Olga, additional, Prudnikova, Olga, additional, Vjushkov, Dmitri Mikhailovich, additional, Egorova, Alla, additional, Orlov, Andrey, additional, Pikalova, Lidiya, additional, Zhuikova, Lilia, additional, Adamcik, Juraj, additional, Safaei Diba, Chakameh, additional, Zadnik, Vesna, additional, Zagar, Tina, additional, De-La-Cruz, Marta, additional, Lopez-de-Munain, Arantza, additional, Aleman, Araceli, additional, Rojas, Dolores, additional, Chillarón, Rosario Jiménez, additional, Navarro, Ana Isabel Marcos, additional, Puigdemont, Montse, additional, Sánchez Perez, María-José, additional, Franch Sureda, Paula, additional, Ramos Montserrat, Maria, additional, Chirlaque López, Maria Dolores, additional, Sánchez Gil, Antonia, additional, Ardanaz, Eva, additional, Guevara, Marcela, additional, Cañete-Nieto, Adela, additional, Peris-Bonet, Rafael, additional, Carulla, Marià, additional, Galceran, Jaume, additional, Almela, Fernando, additional, Sabater, Consol, additional, Khan, Staffan, additional, Pettersson, David, additional, Dickman, Paul, additional, Staehelin, Katharina, additional, Struchen, Benjamin, additional, Herrmann, Christian, additional, Mousavi, Seyed Mohsen, additional, Egger Hayoz, Céline, additional, Bouchardy, Christine, additional, Schaffar, Robin, additional, Went, Philip, additional, Maspoli-Conconi, Manuela, additional, Kuehni, Claudia, additional, Bordoni, Andrea, additional, Ortelli, Laura, additional, Chiolero, Arnaud, additional, Konzelmann, Isabelle, additional, Rohrmann, Sabine, additional, Wanner, Miriam, additional, Broggio, John, additional, Rashbass, Jem, additional, Fitzpatrick, Deirdre, additional, Gavin, Anna, additional, Morrison, David, additional, Thomson, Catherine, additional, Greene, Giles, additional, Huws, Dyfed, additional, Coleman, Michel, additional, Matz, Melissa, additional, Sanz, Natalia, additional, Ssenyonga, Naomi, additional, Stephens, Richard, additional, Chalker, Elizabeth, additional, Smith, Mirka, additional, Gugusheff, Jessica, additional, You, Hui, additional, Qin Li, Shu, additional, Dugdale, Sarah, additional, Moore, Julie, additional, Philpot, Shoni, additional, Pfeiffer, Rhonda, additional, Thomas, Helen, additional, Silva Ragaini, Bruna, additional, Venn, Alison, additional, Evans, Sue, additional, Te Marvelde, Luc, additional, Savietto, Vedrana, additional, Trevithick, Richard, additional, Currow, David, additional, and Lewis, Chris, additional

Published
2022
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27. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort

Author

Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, Bernasconi, Alice, Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, and Bernasconi, Alice

Abstract

Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5-1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions: These results highlight the need to personalize follow-up strategies for AYA cancer survivors.

Published
2022

29. Influence of Sex and Age on Site of Onset, Morphology, and Site of Metastasis in Colorectal Cancer: A Population-Based Study on Data from Four Italian Cancer Registries

Author

Perotti, Viviana, Fabiano, Sabrina, Contiero, Paolo, Michiara, Maria, Musolino, Antonio, Boschetti, Lorenza, Cascone, Giuseppe, Castelli, Maurizio, Tagliabue, Giovanna, and Group, Cancer Registries Working Group Cancer Registries Working

Subjects
Cancer Research, age, Oncology, cancer registry, metastasis, sex, relative survival, colorectal cancer, population-based
Abstract

The prognosis of colorectal cancer is affected by factors such as site of origin, tumor morphology, and metastasis at diagnosis, but also age and sex seem to play a role. This study aimed to investigate within the Italian population how sex and age interact in influencing certain aspects of the disease and how they affect patient survival, particularly in the metastatic cohort. Data from four cancer registries were collected, and patients were classified by sex and age (69 years). Two separate analyses were conducted: one for patients having right or left colon cancer with adenocarcinoma or mucinous morphology, and one for patients having metastases at diagnosis. Women showed significant differences in right colon cases from the youngest to oldest age group (36% vs. 45% vs. 60%). Men

Published
2023
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32. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population‐based cohort

Author

Trama, Annalisa, primary, Tittarelli, Andrea, additional, Barigelletti, Giulio, additional, Botta, Laura, additional, Gatta, Gemma, additional, Tagliabue, Giovanna, additional, Contiero, Paolo, additional, Guzzinati, Stefano, additional, Andreano, Anita, additional, Manneschi, Gianfranco, additional, Falcini, Fabio, additional, Castaing, Marine, additional, Filiberti, Rosa A., additional, Gasparotti, Cinzia, additional, Cirilli, Claudia, additional, Mazzucco, Walter, additional, Mangone, Lucia, additional, Iacovacci, Silvia, additional, Vitale, Maria F., additional, Stracci, Fabrizio, additional, Piffer, Silvano, additional, Tumino, Rosario, additional, Carone, Simona, additional, Sampietro, Giuseppe, additional, Melcarne, Anna, additional, Ballotari, Paola, additional, Boschetti, Lorenza, additional, Pisani, Salvatore, additional, Cavalieri D'Oro, Luca, additional, Cuccaro, Francesco, additional, D'Argenzio, Angelo, additional, D'Orsi, Giancarlo, additional, Fanetti, Anna C., additional, Ardizzone, Antonino, additional, Candela, Giuseppa, additional, Savoia, Fabio, additional, Pascucci, Cristiana, additional, Castelli, Maurizio, additional, Storchi, Cinzia, additional, and Bernasconi, Alice, additional

Published
2021
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33. Municipality Data as a Rapid and Effective Tool to Analyse Spatial and Temporal Variations of All-Cause Mortality by Town District: The Experience in Genoa (Italy)

Author

Contiero, Paolo, primary, Tagliabue, Giovanna, additional, Tittarelli, Andrea, additional, Bertoldi, Martina, additional, Tresoldi, Claudio, additional, Barigelletti, Giulio, additional, Perotti, Viviana, additional, Balbo, Vittoria, additional, Rizzieri, Stefania, additional, D’Orazi, Marco, additional, and Gennaro, Valerio, additional

Published
2021
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37. Variation of Cancer Incidence between and within GRELL Countries

Author

Universitat Rovira i Virgili, Contiero, Paolo; Tagliabue, Giovanna; Gatta, Gemma; Galceran, Jaume; Bulliard, Jean-Luc; Bertoldi, Martina; Scaburri, Alessandra; Crocetti, Emanuele;GRELL Geographic Anal Working Grp, Universitat Rovira i Virgili, and Contiero, Paolo; Tagliabue, Giovanna; Gatta, Gemma; Galceran, Jaume; Bulliard, Jean-Luc; Bertoldi, Martina; Scaburri, Alessandra; Crocetti, Emanuele;GRELL Geographic Anal Working Grp

Published
2021

40. Breast cancer survival in the US and Europe: A CONCORD high-resolution study

Author

Allemani, Claudia, Sant, Milena, Weir, Hannah K., Richardson, Lisa C., Baili, Paolo, Storm, Hans, Siesling, Sabine, Torrella-Ramos, Ana, Voogd, Adri C., Aareleid, Tiiu, Ardanaz, Eva, Berrino, Franco, Bielska-Lasota, Magdalena, Bolick, Susan, Cirilli, Claudia, Colonna, Marc, Contiero, Paolo, Cress, Rosemary, Crocetti, Emanuele, Fulton, John P., Grosclaude, Pascale, Hakulinen, Timo, Izarzugaza, Isabel M., Malmström, Per, Peignaux, Karin, Primic-Žakelj, Maja, Rachtan, Jadwiga, Diba, Chakameh Safaei, Sánchez, Maria-José, Schymura, Maria J., Shen, Tiefu, Traina, Adele, Tryggvadottir, Laufey, Tumino, Rosario, Velten, Michel, Vercelli, Marina, Wolf, Holly J., Woronoff, Anne-Sophie, Wu, Xiaocheng, and Coleman, Michel P.

Published
2013
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43. Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy

Author

Bernasconi, Alice, primary, Barigelletti, Giulio, additional, Tittarelli, Andrea, additional, Botta, Laura, additional, Gatta, Gemma, additional, Tagliabue, Giovanna, additional, Contiero, Paolo, additional, Guzzinati, Stefano, additional, Andreano, Anita, additional, Manneschi, Gianfranco, additional, Falcini, Fabio, additional, Castaing, Marine, additional, Filiberti, Rosa Angela, additional, Gasparotti, Cinzia, additional, Cirilli, Claudia, additional, Mazzucco, Walter, additional, Mangone, Lucia, additional, Iacovacci, Silvia, additional, Vitale, Maria Francesca, additional, Stracci, Fabrizio, additional, Piffer, Silvano, additional, Tumino, Rosario, additional, Carone, Simona, additional, Sampietro, Giuseppe, additional, Melcarne, Anna, additional, Ballotari, Paola, additional, Boschetti, Lorenza, additional, Pisani, Salvatore, additional, Cavalieri D'Oro, Luca, additional, Cuccaro, Francesco, additional, D'Argenzio, Angelo, additional, D'Orsi, Giancarlo, additional, Fanetti, Anna Clara, additional, Ardizzone, Antonino, additional, Candela, Giuseppa, additional, Savoia, Fabio, additional, Pascucci, Cristiana, additional, Castelli, Maurizio, additional, Storchi, Cinzia, additional, and Trama, Annalisa, additional

Published
2020
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44. Epidemiology of Soft Tissue Sarcoma and Bone Sarcoma inItaly: Analysis of Data from 15 Population-Based Cancer Registries

Author

Fabiano, Sabrina, primary, Contiero, Paolo, additional, Barigelletti, Giulio, additional, D’Agostino, Anna, additional, Tittarelli, Andrea, additional, Mangone, Lucia, additional, Bisceglia, Isabella, additional, Bongiorno, Salvatore, additional, De Lorenzis, Lucia Elena, additional, Mazzoleni, Guido, additional, Castaing, Marine, additional, Intrieri, Teresa, additional, Puppo, Antonella, additional, Carrozzi, Giuliano, additional, Sini, Giovanna Maria, additional, Fontanili, llaria, additional, Boschetti, Lorenza, additional, Tumino, Rosario, additional, Bella, Francesca, additional, Fanetti, AnnaClara, additional, Castelli, Maurizio, additional, Ardizzone, Antonio, additional, Vittadello, Fabio, additional, Sciacca, Salvatore, additional, Manneschi, Gianfranco, additional, Casella, Claudia, additional, Cirilli, Claudia, additional, Pala, Filomena, additional, Michiara, Maria, additional, Migliazza, Simona, additional, Ferrari, Francesca, additional, Spata, Eugenia, additional, Dinaro, Ylenia, additional, Cometti, Ivan, additional, Maghini, Anna, additional, and Tagliabue, Giovanna, additional

Published
2020
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45. A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Author

Allen, Naomi E., Roddam, Andrew W., Sieri, Sabina, Boeing, Heiner, Jakobsen, Marianne Uhre, Overvad, Kim, Tjnneland, Anne, Halkjær, Jytte, Vineis, Paolo, Contiero, Paolo, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Kaaks, Rudolf, Rohrmann, Sabine, Trichopoulou, Antonia, Zilis, Demosthenes, Koumantaki, Yvoni, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Barricarte, Aurelio, Rodríguez, Laudina, Dorronsoro, Miren, Sánchez, Maria-José, Chirlaque, María Dolores, Esquius, Laura, Manjer, Jonas, Wallström, Peter, Ljungberg, Börje, Hallmans, Göran, Bingham, Sheila, Khaw, Kay-Tee, Boffetta, Paolo, Norat, Teresa, Mouw, Traci, and Riboli, Elio

Published
2009
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47. Late Mortality, Subsequent Malignant Neoplasms and Hospitalisations in Long-Term Survivors of Adolescent and Young Adult Hematological Cancers.

Author

Trama, Annalisa, Vener, Claudia, Lasalvia, Paolo, Bernasconi, Alice, Zorzi, Manuel, Andreano, Anita, Contiero, Paolo, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa Angela, Gasparotti, Cinzia, Cirilli, Claudia, Amodio, Rosalba, Bisceglia, Isabella, Iacovacci, Silvia, Vitale, Maria Francesca, Stracci, Fabrizio, Gentilini, Maria Adalgisa, and Tumino, Rosario

Subjects
HEMATOLOGIC malignancies, YOUNG adults, CANCER patients, TEENAGERS, TUMORS, NON-communicable diseases
Abstract

Background: Increased success in the treatment of hematological cancers contributed to the increase of 5-year survival for most adolescent and young adults (AYAs) with these tumours. However, as 5-year survival increased, it became clear that AYA long-term survivors were at increased risk for severe late effects. Moreover, limited information on long-term cancer impact is available for AYAs, since most studies focused on children and adolescents. We aimed to assess various long-term outcomes on AYA survivors of hematological cancers. Methods: We selected patients diagnosed with a first primary hematological cancer between 1997 and 2006, in the Italian nationwide population-based cohort of AYA cancer survivors (i.e. alive at least 5 years after cancer diagnosis). Long-term outcomes of interest were: second malignant neoplasms (SMNs), hospitalizations and overall mortality. We calculated standardized incidence ratios (SIRs), standardized hospitalization rate ratios (SHRs) and standardized mortality rate ratios (SMRs). To study morbidity patterns over time, we modeled observed incidence rates by fitting flexible parametric models for nonlinear patterns and we used linear regression for linear patterns. Results: The study cohort included 5,042 AYA hematological cancer survivors of which 1,237 and 3,805 had a leukaemia and lymphoma diagnosis, respectively. AYA survivors were at substantially increased risk for SMN (SIR=2.1; 95%CI=1.7; 2.6), hospitalisation (SHR=1.5; 95%CI=1.5; 1.6), and mortality (SMR=1.4; 95%CI=1.2; 1.6) with differences between leukaemia and lymphoma survivors. The highest excess risks of hospitalisations were for infectious diseases, respiratory diseases, and diseases of blood and blood-forming organs. The morbidity pattern differs over time by morbidity type. Conclusions: Our results support the need for strict follow-up plans for survivors, and call for further study to better personalised follow-up plans for AYA cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

Heath, Alicia K, Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Standahl Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., Tzoulaki, Ioanna, Heath, Alicia K, Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Standahl Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna

Abstract

BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.

Published
2020
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49. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, Tzoulaki, Ioanna, MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, and Tzoulaki, Ioanna

Published
2020

50. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population‐based cohort.

Author

Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A., Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F., and Stracci, Fabrizio

Subjects
YOUNG adults, CANCER patients, CANCER survivors, BLADDER cancer, TEENAGERS, DIGESTIVE organs, OVARIAN cancer
Abstract

Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow‐up care. Methods: Population‐based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15‐39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5‐1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions: These results highlight the need to personalize follow‐up strategies for AYA cancer survivors. Most subsequent malignant neoplasms (SMNs) in adolescent and young adult cancer survivors are preventable. The results of this study call for dedicated interventions (eg, behavioral change interventions and surveillance) aimed at minimizing the number of SMNs in these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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