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2. Supplementary Tables 1-4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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4. Supplementary Table 1 from [18F]-3′Deoxy-3′-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., primary, Stebbing, Justin, primary, Rosso, Lula, primary, Ahmad, Rizvana, primary, Jacob, Jimmy, primary, Challapalli, Amarnath, primary, Turkheimer, Federico, primary, Al-Nahhas, Adil, primary, Sharma, Rohini, primary, Coombes, R. Charles, primary, and Aboagye, Eric O., primary

Published
2023
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5. Supplementary Figure 4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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6. Supplementary Figure 6 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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7. Supplementary Figure 1 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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8. Supplementary Figure 2 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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9. Supplementary Figure 3 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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11. Supplementary Table 2 from [18F]-3′Deoxy-3′-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., primary, Stebbing, Justin, primary, Rosso, Lula, primary, Ahmad, Rizvana, primary, Jacob, Jimmy, primary, Challapalli, Amarnath, primary, Turkheimer, Federico, primary, Al-Nahhas, Adil, primary, Sharma, Rohini, primary, Coombes, R. Charles, primary, and Aboagye, Eric O., primary

Published
2023
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12. Supplementary Figure 5 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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13. Supplementary Figure Legends 1-7 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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14. Supplementary Table 3 from [18F]-3′Deoxy-3′-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., primary, Stebbing, Justin, primary, Rosso, Lula, primary, Ahmad, Rizvana, primary, Jacob, Jimmy, primary, Challapalli, Amarnath, primary, Turkheimer, Federico, primary, Al-Nahhas, Adil, primary, Sharma, Rohini, primary, Coombes, R. Charles, primary, and Aboagye, Eric O., primary

Published
2023
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15. Supplementary Figure 7 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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22. Male breast cancer: is the scenario changing

Author

Kulkarni Dhananjay M, Rodrigues Gabriel S, Kaur Kanchan, Contractor Kaiyumars B, and Singhal Hemant

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects of male breast cancer with particular emphasis on incidence, risk factors, patho-physiology, treatment, prognostic factors, and outcome. Methods Information on all aspects of male breast cancer was gathered from available relevant literature on male breast cancer from the MEDLINE database over the past 32 years from 1975 to 2007. Various reported studies were scrutinized for emerging evidence. Incidence data were also obtained from the IARC, Cancer Mondial database. Conclusion There is a scenario of rising incidence, particularly in urban US, Canada and UK. Even though more data on risk factors is emerging about this disease, more multi-institutional efforts to pool data with large randomized trials to show treatment and survival benefits are needed to support the existing vast emerging knowledge about the disease.

Published
2008
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25. Imaging of cellular proliferation in liver metastasis by [18F]fluorothymidine positron emission tomography: effect of therapy

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, additional, Tomasi, Giampaolo, additional, Rosso, Lula, additional, Wasan, Harpreet, additional, Stebbing, Justin, additional, Kenny, Laura, additional, Mangar, Stephen, additional, Riddle, Pippa, additional, Palmieri, Carlo, additional, Al-Nahhas, Adil, additional, Sharma, Rohini, additional, Turkheimer, Federico, additional, Coombes, R Charles, additional, and Aboagye, Eric, additional

Published
2012
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26. Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, additional, Barwick, Tara, additional, Winkler, Mathias, additional, Hellawell, Giles, additional, Hazell, Steve, additional, Tomasi, Giampaolo, additional, Al-Nahhas, Adil, additional, Mapelli, Paola, additional, Kenny, Laura M., additional, Tadrous, Paul, additional, Coombes, R. Charles, additional, Aboagye, Eric O., additional, and Mangar, Stephen, additional

Published
2011
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27. [18F]-3′Deoxy-3′-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., additional, Stebbing, Justin, additional, Rosso, Lula, additional, Ahmad, Rizvana, additional, Jacob, Jimmy, additional, Challapalli, Amarnath, additional, Turkheimer, Federico, additional, Al-Nahhas, Adil, additional, Sharma, Rohini, additional, Coombes, R. Charles, additional, and Aboagye, Eric O., additional

Published
2011
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31. [11C]Choline Positron Emission Tomography in Estrogen Receptor–Positive Breast Cancer

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., additional, Stebbing, Justin, additional, Al-Nahhas, Adil, additional, Palmieri, Carlo, additional, Sinnett, Dudley, additional, Lewis, Jacqueline S., additional, Hogben, Katy, additional, Osman, Safiye, additional, Shousha, Sami, additional, Lowdell, Charles, additional, Coombes, R. Charles, additional, and Aboagye, Eric O., additional

Published
2009
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35. Phase I Trial of the Positron-Emitting Arg-Gly-Asp (RGD) Peptide Radioligand 18F-AH111585 in Breast Cancer Patients

Author

Kenny, Laura M., primary, Coombes, R. Charles, additional, Oulie, Inger, additional, Contractor, Kaiyumars B., additional, Miller, Matthew, additional, Spinks, Terence J., additional, McParland, Brian, additional, Cohen, Pamela S., additional, Hui, Ai-Min, additional, Palmieri, Carlo, additional, Osman, Safiye, additional, Glaser, Matthias, additional, Turton, David, additional, Al-Nahhas, Adil, additional, and Aboagye, Eric O., additional

Published
2008
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37. Imaging of cellular proliferation in liver metastasis by [18F]fluorothymidine positron emission tomography: effect of therapy.

Author

Contractor, Kaiyumars, Challapalli, Amarnath, Tomasi, Giampaolo, Rosso, Lula, Wasan, Harpreet, Stebbing, Justin, Kenny, Laura, Mangar, Stephen, Riddle, Pippa, Palmieri, Carlo, Al-Nahhas, Adil, Sharma, Rohini, Turkheimer, Federico, Coombes, R. Charles, and Aboagye, Eric

Subjects
*MEDICAL imaging systems, *CELL proliferation, *LIVER metastasis, *POSITRON emission tomography, *KINASES, *CANCER chemotherapy, *MATHEMATICAL variables
Abstract

Although [18F]fluorothymidine positron emission tomography (FLT-PET) permits estimation of tumor thymidine kinase-1 expression, and thus, cell proliferation, high physiological uptake of tracer in liver tissue can limit its utility. We evaluated FLT-PET combined with a temporalintensity information-based voxel-clustering approach termed kinetic spatial filtering (FLT-PETKSF) for detecting drug response in liver metastases. FLT-PET and computed tomography data were collected from patients with confirmed breast or colorectal liver metastases before, and two weeks after the first cycle of chemotherapy. Changes in tumor FLT-PET and FLT-PETKSF variables were determined. Visual distinction between tumor and normal liver was seen in FLT-PETKSF images. Of the 33 metastases from 20 patients studied, 26 were visible after kinetic filtering. The net irreversible retention of the tracer (Ki; from unfiltered data) in the tumor, correlated strongly with tracer uptake when the imaging variable was an unfiltered average or maximal standardized uptake value, 60 min postinjection (SUV60,av: r = 0.9, SUV60,max: r = 0.7; p < 0.0001 for both) and occurrence of high intensity voxels derived from FLT-PETKSF (r = 0.7, p < 0.0001). Overall, a significant reduction in the imaging variables was seen in responders compared to non-responders; however, the two week time point selected for imaging was too early to allow prediction of long term clinical benefit from chemotherapy. FLT-PET and FLT-PETKSF detected changes in proliferation in liver metastases. [ABSTRACT FROM AUTHOR]

Published
2012
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41. Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography.

Author

Contractor KB, Kenny LM, Stebbing J, Challapalli A, Al-Nahhas A, Palmieri C, Shousha S, Lewis JS, Hogben K, De Nguyen Q, Coombes RC, and Aboagye EO

Subjects
Adenocarcinoma pathology, Adult, Aged, Breast Neoplasms pathology, Carbon Radioisotopes, Cell Proliferation, Female, Humans, Ki-67 Antigen blood, Middle Aged, Radiopharmaceuticals, Adenocarcinoma diagnostic imaging, Breast Neoplasms diagnostic imaging, Choline, Choline Kinase metabolism, Fluorodeoxyglucose F18, Ki-67 Antigen metabolism, Positron-Emission Tomography methods
Abstract

Objective: The biological significance of [¹¹C]choline (CHO) uptake in human tumours is unclear and probably linked to choline kinase-α (CHKα) expression and cell proliferation. We directly compared CHO with [¹⁸F]fluorothymidine (FLT), an imaging biomarker of proliferation, by positron emission tomography (PET) in patients with breast cancer to investigate whether cell proliferation is an important determinant of CHO uptake. Furthermore, we evaluated CHKα and the Ki67-labelling index (LIKi67) in tumour biopsies., Methods: Sequential CHO-PET and FLT-PET within the same imaging session were performed in 21 patients with oestrogen receptor (ER)-positive breast cancer (28 lesions). Average and maximum CHO standardized uptake values (SUV) at 60 min: SUV60,av, and SUV60,max, and the rate constant of net irreversible uptake, Ki, were compared with FLT uptake at 60 min: SUV60,av and SUV60,max. Biopsies were stained for CHKα and LIKi67 in eight cases., Results: Tumours were equally visible on CHO-PET and FLT-PET imaging. Tumour CHO-PET strongly correlated with FLT imaging variables (Pearson's r=0.83; P<0.0001 for CHO-SUV60,max vs. FLT-SUV60,max). A statistically significant association was found between CHO-PET variables and categorical scores of cytoplasmic CHKα intensity and between FLT-PET and LIKi67 (P<0.05, one-way analysis of variance)., Conclusion: Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting. CHO uptake was also found to be related to cytoplasmic CHKα expression.

Published
2011
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