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13 results on '"Contreras-Trujillo, Humberto"'

2. CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

Author

Cheah, Ming T, Chen, James Y, Sahoo, Debashis, Contreras-Trujillo, Humberto, Volkmer, Anne K, Scheeren, Ferenc A, Volkmer, Jens-Peter, and Weissman, Irving L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Urologic Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Cell Line, Tumor, Cell Proliferation, Cytokines, Flow Cytometry, Fluorescent Antibody Technique, Gene Expression Regulation, Neoplastic, Humans, Inflammation Mediators, Interleukin Receptor Common gamma Subunit, Keratin-14, Lipopolysaccharide Receptors, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, Mice, Transgenic, Neoplasm Transplantation, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transplantation, Heterologous, Tumor Microenvironment, Urinary Bladder Neoplasms, bladder cancer, CD14, inflammation, microenvironment
Abstract

Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) as a model, we found that CD14-high cancer cells express higher levels of numerous inflammation mediators and form larger tumors compared with CD14-low cells. CD14 antigen is a glycosyl-phosphatidylinositol (GPI)-linked glycoprotein and has been shown to be critically important in the signaling pathways of Toll-like receptor (TLR). CD14 expression in this BC subpopulation of cancer cells is required for increased cytokine production and increased tumor growth. Furthermore, tumors formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration. Inflammatory factors produced by CD14-high BC cells recruit and polarize monocytes and macrophages to acquire immune-suppressive characteristics. In contrast, CD14-low BC cells have a higher baseline cell division rate than CD14-high cells. Importantly, CD14-high cells produce factors that further increase the proliferation of CD14-low cells. Collectively, we demonstrate that CD14-high BC cells may orchestrate tumor-promoting inflammation and drive tumor cell proliferation to promote tumor growth.

Published
2015

6. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Author

Willingham, Stephen B., Volkmer, Jens-Peter, Gentles, Andrew J., Sahoo, Debashis, Dalerba, Piero, Mitra, Siddhartha S., Wang, Jian, Contreras-Trujillo, Humberto, Martin, Robin, Cohen, Justin D., Lovelace, Patricia, Scheeren, Ferenc A., Chao, Mark P., Weiskopf, Kipp, Tang, Chad, Volkmer, Anne Kathrin, Naik, Tejaswitha J., Storm, Theresa A., Mosley, Adriane R., Edris, Badreddin, Schmid, Seraina M., Sun, Chris K., Chua, Mei-Sze, Murillo, Oihana, Rajendran, Pradeep, Cha, Adriel C., Chin, Robert K., Kim, Dongkyoon, Adorno, Maddalena, Raveh, Tal, Tseng, Diane, Jaiswal, Siddhartha, Enger, Per Øyvind, Steinberg, Gary K., Li, Gordon, So, Samuel K., Majeti, Ravindra, Harsh, Griffith R., van de Rijn, Matt, Teng, Nelson N. H., Sunwoo, John B., Alizadeh, Ash A., Clarke, Michael F., and Weissman, Irving L.

Published
2012

7. Three differentiation states risk-stratify bladder cancer into distinct subtypes

Author

Volkmer, Jens-Peter, Sahoo, Debashis, Chin, Robert K., Ho, Philip Levy, Tang, Chad, Kurtova, Antonina V., Willingham, Stephen B., Pazhanisamy, Senthil K., Contreras-Trujillo, Humberto, Storm, Theresa A., Lotan, Yair, Beck, Andrew H., Chung, Benjamin I., Alizadeh, Ash A., Godoy, Guilherme, Lerner, Seth P., van de Rijn, Matt, Shortliffe, Linda D., Weissman, Irving L., and Chan, Keith S.

Published
2012

8. Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

Author

Lu, Rong, primary, CONTRERAS-TRUJILLO, HUMBERTO, additional, EERDENG, JIYA, additional, AKRE, SAMIR, additional, JIANG, DU, additional, JORAPUR, APARNA, additional, VERGEL-RODRIGUEZ, MARY, additional, ANDREASIAN, AREEN, additional, HARTON, LISA, additional, Bramlett, Charles, additional, GALA, BASIA, additional, Nogalska, Anna, additional, Chan, Lai, additional, Xiao, Gang, additional, LEE, JAE-WOONG, additional, MÜSCHEN, MARKUS, additional, and MERCHANT, AKIL, additional

Published
2021
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11. In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration

Author

Rinkevich, Yuval, primary, Montoro, Daniel T., additional, Contreras-Trujillo, Humberto, additional, Harari-Steinberg, Orit, additional, Newman, Aaron M., additional, Tsai, Jonathan M., additional, Lim, Xinhong, additional, Van-Amerongen, Renee, additional, Bowman, Angela, additional, Januszyk, Michael, additional, Pleniceanu, Oren, additional, Nusse, Roel, additional, Longaker, Michael T., additional, Weissman, Irving L., additional, and Dekel, Benjamin, additional

Published
2014
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