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3. Diagnosis of chronic pancreatitis using semi-quantitative MRI features of the pancreatic parenchyma: results from the multi-institutional MINIMAP study

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L., Territo, Paul R., Zhao, Xuandong, Persohn, Scott A., Dasyam, Anil K., Shah, Zarine K., Venkatesh, Sudhakar K., Takahashi, Naoki, Wachsman, Ashley, Li, Liang, Li, Yan, Pandol, Stephen J., Park, Walter G., Vege, Santhi Swaroop, Hart, Phil A., Topazian, Mark, Andersen, Dana K., and Fogel, Evan L.

Published
2023
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4. Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study

Author

Hart, Phil A, Papachristou, Georgios I, Park, Walter G, Dyer, Anne-Marie, Chinchilli, Vernon M, Afghani, Elham, Akshintala, Venkata S, Andersen, Dana K, Buxbaum, James L, Conwell, Darwin L, Dungan, Kathleen M, Easler, Jeffrey J, Fogel, Evan L, Greenbaum, Carla J, Kalyani, Rita R, Korc, Murray, Kozarek, Richard, Laughlin, Maren R, Lee, Peter J, Maranki, Jennifer L, Pandol, Stephen J, Phillips, Anna Evans, Serrano, Jose, Singh, Vikesh K, Speake, Cate, Tirkes, Temel, Toledo, Frederico GS, Trikudanathan, Vege, Santhi Swaroop, Wang, Ming, Yazici, Cemal, Zaheer, Atif, Forsmark, Christopher E, Bellin, Melena D, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Diabetes, Acute Disease, Diabetes Mellitus, Type 1, Humans, Incidence, Pancreatitis, Prospective Studies, pancreatogenic diabetes, type 3c diabetes, beta cell, insulin, autoantibody, epidemiology, AP, acute pancreatitis, CP, chronic pancreatitis, DCC, data coordinating center, DM, diabetes mellitus, DREAM, Diabetes RElated to Acute pancreatitis and its Mechanisms, FSIGTT, frequently sampled intravenous glucose tolerance testing, OGTT, oral glucose tolerance testing, MMTT, mixed meal tolerance testing, T1DAPC, Type 1 Diabetes in Acute Pancreatitis Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

AbstractAcute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Published
2022

5. Circulating immune signatures in chronic pancreatitis with and without preceding acute pancreatitis: A pilot study

Author

Hagn-Meincke, Rasmus, Yadav, Dhiraj, Andersen, Dana K., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Bellin, Melena D., Topazian, Mark D., Conwell, Darwin L., Li, Liang, Van Den Eeden, Stephen K., Drewes, Asbjørn M., Pandol, Stephen J., Forsmark, Chris E., Fisher, William E., Hart, Phil A., Olesen, Søren S., and Park, Walter G.

Published
2024
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6. A Randomized Controlled Phase 2 Dose-Finding Trial to Evaluate the Efficacy and Safety of Camostat in the Treatment of Painful Chronic Pancreatitis: The TACTIC Study

Author

Hart, Phil A., Osypchuk, Yurii, Hovbakh, Iryna, Shah, Raj J., Nieto, Jose, Cote, Gregory A., Avgaitis, Sergii, Kremzer, Oleksandr, Buxbaum, James, Inamdar, Sumant, Fass, Ronnie, Phillips, Raymond W., Yadav, Dhiraj, Ladd, Antonio Mendoza, Al-Assi, M. Tarek, Gardner, Timothy, Conwell, Darwin L., Irani, Shayna, Sheikh, Aasim, and Nuttall, Janet

Published
2024
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7. Systemic Neutrophil Gelatinase-Associated Lipocalin Alterations in Chronic Pancreatitis: A Multicenter, Cross-Sectional Study

Author

Gumpper-Fedus, Kristyn, Chasser, Kaylin, Pita-Grisanti, Valentina, Torok, Molly, Pfau, Timothy, Mace, Thomas A., Cole, Rachel M., Belury, Martha A., Culp, Stacey, Hart, Phil A., Krishna, Somashekar G., Lara, Luis F., Ramsey, Mitchell L., Fisher, William, Fogel, Evan L., Forsmark, Chris E., Li, Liang, Pandol, Stephen, Park, Walter G., Serrano, Jose, Van Den Eeden, Stephen K., Vege, Santhi Swaroop, Yadav, Dhiraj, Conwell, Darwin L., and Cruz-Monserrate, Zobeida

Published
2024
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8. Pancreatitis pain quality changes at year 1 follow-up, but GP130 remains a biomarker for pain

Author

Saloman, Jami L, Jennings, Kristofer, Stello, Kimberly, Li, Shuang, Evans Phillips, Anna, Hall, Kristen, Fogel, Evan L., Vege, Santhi Swaroop, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark D., Van Den Eeden, Stephen K., Serrano, Jose, Conwell, Darwin L., Li, Liang, and Yadav, Dhiraj

Published
2024
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9. Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019.

Author

Elmunzer, B, Spitzer, Rebecca, Foster, Lydia, Merchant, Ambreen, Howard, Eric, Patel, Vaishali, West, Mary, Qayed, Emad, Nustas, Rosemary, Zakaria, Ali, Piper, Marc, Taylor, Jason, Jaza, Lujain, Forbes, Nauzer, Chau, Millie, Lara, Luis, Papachristou, Georgios, Volk, Michael, Hilson, Liam, Zhou, Selena, Kushnir, Vladimir, Lenyo, Alexandria, McLeod, Caroline, Amin, Sunil, Kuftinec, Gabriela, Yadav, Dhiraj, Fox, Charlie, Kolb, Jennifer, Pawa, Swati, Pawa, Rishi, Canakis, Andrew, Huang, Christopher, Jamil, Laith, Aneese, Andrew, Glamour, Benita, Smith, Zachary, Hanley, Katherine, Wood, Jordan, Patel, Harsh, Shah, Janak, Agarunov, Emil, Sethi, Amrita, Fogel, Evan, McNulty, Gail, Haseeb, Abdul, Trieu, Judy, Dixon, Rebekah, Yang, Jeong, Mendelsohn, Robin, Calo, Delia, Aroniadis, Olga, LaComb, Joseph, Scheiman, James, Sauer, Bryan, Dang, Duyen, Piraka, Cyrus, Shah, Eric, Pohl, Heiko, Tierney, William, Mitchell, Stephanie, Condon, Ashwinee, Lenhart, Adrienne, Dua, Kulwinder, Kanagala, Vikram, Kamal, Ayesha, Singh, Vikesh, Pinto-Sanchez, Maria, Hutchinson, Joy, Kwon, Richard, Korsnes, Sheryl, Singh, Harminder, Solati, Zahra, Willingham, Field, Yachimski, Patrick, Conwell, Darwin, Mosier, Evan, Azab, Mohamed, Patel, Anish, Buxbaum, James, Wani, Sachin, Chak, Amitabh, Hosmer, Amy, Keswani, Rajesh, DiMaio, Christopher, Bronze, Michael, Muthusamy, Raman, Canto, Marcia, Gjeorgjievski, V, Imam, Zaid, Odish, Fadi, Edhi, Ahmed, Orosey, Molly, Tiwari, Abhinav, Patwardhan, Soumil, Brown, Nicholas, Ordiah, Collins, Sloan, Ian, Cruz, Lilian, and Koza, Casey

Subjects
COVID-19, Digestive Manifestations, Gastrointestinal Symptoms, Hepatic Manifestations, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, North America, Young Adult
Abstract

BACKGROUND & AIMS: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients hospitalized with COVID-19. METHODS: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, and endoscopic findings from the time of symptom onset until discharge or death were abstracted manually from electronic health records to characterize the prevalence, spectrum, and severity of digestive manifestations. Regression analyses were performed to evaluate the association between digestive manifestations and severe outcomes related to COVID-19. RESULTS: A total of 1992 patients across 36 centers met eligibility criteria and were included. Overall, 53% of patients experienced at least 1 gastrointestinal symptom at any time during their illness, most commonly diarrhea (34%), nausea (27%), vomiting (16%), and abdominal pain (11%). In 74% of cases, gastrointestinal symptoms were judged to be mild. In total, 35% of patients developed an abnormal alanine aminotransferase or total bilirubin level; these were increased to less than 5 times the upper limit of normal in 77% of cases. After adjusting for potential confounders, the presence of gastrointestinal symptoms at any time (odds ratio, 0.93; 95% CI, 0.76-1.15) or liver test abnormalities on admission (odds ratio, 1.31; 95% CI, 0.80-2.12) were not associated independently with mechanical ventilation or death. CONCLUSIONS: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common, but the majority were mild and their presence was not associated with a more severe clinical course.

Published
2021

10. Dietary Patterns of Insulinemia, Inflammation and Glycemia, and Pancreatic Cancer Risk: Findings from the Women's Health Initiative

Author

Jin, Qi, Hart, Phil A, Shi, Ni, Joseph, Joshua J, Donneyong, Macarius, Conwell, Darwin L, Clinton, Steven K, Cruz-Monserrate, Zobeida, Brasky, Theodore M, Tinker, Lesley F, Liu, Simin, Shadyab, Aladdin H, Thomson, Cynthia A, Qi, Lihong, Rohan, Thomas, and Tabung, Fred K

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Nutrition, Aging, Digestive Diseases, Prevention, Diabetes, Obesity, Rare Diseases, Pancreatic Cancer, Cancer, Metabolic and endocrine, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Diet Surveys, Feeding Behavior, Female, Follow-Up Studies, Glycemic Index, Glycemic Load, Humans, Hyperinsulinism, Inflammation, Insulin, Middle Aged, Pancreatic Neoplasms, Risk Assessment, Risk Factors, United States, Women's Health, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundPancreatic cancer risk is increasing in countries with high consumption of Western dietary patterns and rising obesity rates. We examined the hypothesis that specific dietary patterns reflecting hyperinsulinemia (empirical dietary index for hyperinsulinemia; EDIH), systemic inflammation (empirical dietary inflammatory pattern; EDIP), and postprandial glycemia [glycemic index (GI); glycemic load (GL)] are associated with pancreatic cancer risk, including the potential modifying role of type 2 diabetes (T2D) and body mass index (BMI).MethodsWe calculated dietary scores from baseline (1993-1998) food frequency questionnaires among 129,241 women, 50-79 years-old in the Women's Health Initiative. We used multivariable-adjusted Cox regression to estimate HRs and 95% confidence intervals (95% CI) for pancreatic cancer risk.ResultsDuring a median 19.9 years of follow-up, 850 pancreatic cancer cases were diagnosed. We observed no association between dietary scores and pancreatic cancer risk overall. However, risk was elevated among participants with longstanding T2D (present >3 years before pancreatic cancer diagnosis) for EDIH. For each 1 SD increment in dietary score, the HRs (95% CIs) were: EDIH, 1.33 (1.06-1.66); EDIP, 1.26 (0.98-1.63); GI, 1.26 (0.96-1.67); and GL, 1.23 (0.96-1.57); although interactions were not significant (all P interaction >0.05). Separately, we observed inverse associations between GI [0.86 (0.76-0.96), P interaction = 0.0068] and GL [0.83 (0.73-0.93), P interaction = 0.0075], with pancreatic cancer risk among normal-weight women.ConclusionsWe observed no overall association between the dietary patterns evaluated and pancreatic cancer risk, although women with T2D appeared to have greater cancer risk.ImpactThe elevated risk for hyperinsulinemic diets among women with longstanding T2D and the inverse association among normal-weight women warrant further examination.

Published
2021

11. Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis

Author

Saloman, Jami L., Li, Yan, Stello, Kimberly, Li, Wenhao, Li, Shuang, Phillips, Anna Evans, Hall, Kristen, Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark D., Van Den Eeden, Stephen K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2023
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12. Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women

Author

Jin, Qi, Shi, Ni, Aroke, Desmond, Lee, Dong Hoon, Joseph, Joshua J, Donneyong, Macarius, Conwell, Darwin L, Hart, Phil A, Zhang, Xuehong, Clinton, Steven K, Cruz-Monserrate, Zobeida, Brasky, Theodore M, Jackson, Rebecca, Tinker, Lesley F, Liu, Simin, Phillips, Lawrence S, Shadyab, Aladdin H, Nassir, Rami, Bao, Wei, and Tabung, Fred K

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Prevention, Aging, Diabetes, Metabolic and endocrine, Diabetes Mellitus, Type 2, Diet, Dietary Carbohydrates, Female, Glycemic Index, Humans, Postmenopause, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveThe empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores assess the insulinemic and inflammatory potentials of habitual dietary patterns, irrespective of the macronutrient content, and are based on plasma insulin response or inflammatory biomarkers, respectively. The glycemic index (GI) and glycemic load (GL) assess postprandial glycemic potential based on dietary carbohydrate content. We tested the hypothesis that dietary patterns promoting hyperinsulinemia, chronic inflammation, or hyperglycemia may influence type 2 diabetes risk.Research design and methodsWe calculated dietary scores from baseline (1993-1998) food frequency questionnaires among 73,495 postmenopausal women in the Women's Health Initiative, followed through March 2019. We used multivariable-adjusted Cox regression to estimate hazard ratios (HRs) and 95% CIs for type 2 diabetes risk. We also estimated multivariable-adjusted absolute risk of type 2 diabetes.ResultsDuring a median 13.3 years of follow-up, 11,009 incident cases of type 2 diabetes were diagnosed. Participants consuming the most hyperinsulinemic or proinflammatory dietary patterns experienced greater risk of type 2 diabetes; HRs (95% CI) comparing highest to lowest dietary index quintiles were EDIH 1.49 (1.32-1.68; P trend < 0.0001) and EDIP 1.45 (1.29-1.63; P trend < 0.0001). The absolute excess incidence for the same comparison was 220 (EDIH) and 271 (EDIP) cases per 100,000 person-years. GI and GL were not associated with type 2 diabetes risk: GI 0.99 (0.88-1.12; P trend = 0.46) and GL 1.01 (0.89-1.16; P trend = 0.30).ConclusionsOur findings in this diverse cohort of postmenopausal women suggest that lowering the insulinemic and inflammatory potentials of the diet may be more effective in preventing type 2 diabetes than focusing on glycemic foods.

Published
2021

13. Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L., Territo, Paul R., Zhao, Xuandong, Persohn, Scott A., Dasyam, Anil K., Shah, Zarine K., Venkatesh, Sudhakar K., Takahashi, Naoki, Wachsman, Ashley, Li, Liang, Li, Yan, Pandol, Stephen J., Park, Walter G., Vege, Santhi S., Hart, Phil A., Topazian, Mark, Andersen, Dana K., and Fogel, Evan L.

Published
2022
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15. Distinct Serum Immune Profiles Define the Spectrum of Acute and Chronic Pancreatitis From the Multicenter Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) Study

Author

Li, Liang, Yadav, Dhiraj, Conwell, Darwin L., Hart, Phil A., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Andersen, Dana, Bellin, Melena D., Topazian, Mark, Van Den Eeden, Stephen K., Pandol, Stephen J., Forsmark, Chris, Fisher, William E., Park, Walter G., Lee, Bomi, Jones, Elaina K., Manohar, Murli, Topazian, Mark D., Forsmark, Chris E., Husain, Sohail Z., and Habtezion, Aida

Published
2023
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16. Identification of Individuals at Increased Risk for Pancreatic Cancer in a Community-Based Cohort of Patients With Suspected Chronic Pancreatitis.

Author

Jeon, Christie, Chen, Qiaoling, Yu, Wei, Dong, Elizabeth, Chung, Joanie, Pandol, Stephen, Yadav, Dhiraj, Conwell, Darwin, and Wu, Bechien

Subjects
Adult, Aged, Aged, 80 and over, Early Detection of Cancer, Electronic Health Records, Female, Humans, Incidence, Male, Middle Aged, Natural Language Processing, Pancreas, Pancreatic Neoplasms, Pancreatitis, Chronic, Patient Selection, Registries, Retrospective Studies, Risk Assessment, Tomography, X-Ray Computed
Abstract

OBJECTIVES: We lack reliable methods for identifying patients with chronic pancreatitis (CP) at increased risk for pancreatic cancer. We aimed to identify radiographic parameters associated with pancreatic cancer in this population. METHODS: We conducted a retrospective cohort study of patients with suspected CP within an integrated healthcare system in Southern California in 2006-2015. Patients were identified by a diagnostic code and confirmed by imaging findings (parenchymal calcification, ductal stones, glandular atrophy, pseudocyst, main duct dilatation, duct irregularity, abnormal side branch, or stricture) defined by the natural language processing of radiographic reports. We used Cox regression to determine the relationship of smoking, alcohol use, acute pancreatitis, diabetes, body mass index, and imaging features with the risk of incident pancreatic cancer at least 1 year after abnormal pancreas imaging. RESULTS: We identified 1,766 patients with a diagnostic code and an imaging feature for CP with a median follow-up of 4.5 years. There were 46 incident pancreatic cancer cases. Factors that predicted incident pancreatic cancer after 1-year of follow-up included obesity (hazard ratio 2.7, 95% confidence interval: 1.2-6.1) and duct dilatation (hazard ratio 10.5, 95% confidence limit: 4.0-27). Five-year incidence of pancreatic cancer in this population with duct dilatation was 6.3%. DISCUSSION: High incidence of pancreatic cancer in suspected patients with CP with pancreatic duct dilatation warrants regular surveillance for pancreatic cancer.

Published
2020

18. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Author

Bellin, Melena D., Beilman, Greg, Brand, Randall E., Shelton Ohlsen, Celeste, Saloman, Jami L., Whitcomb, David C., Park, H.J., Lee, Kenneth K., Paniccia, Alessandro, Zureikat, Amer, Alkaade, Samer, Amann, Stephen, Anderson, Michelle A., Banks, Peter, Conwell, Darwin L., Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini M., Lewis, Michele D., Muniraj, Thiruvengadam, Papachristou, Georgios I., Romagnuolo, Joseph, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Melbern Wilcox, Charles, Yadav, Dhiraj, Fu, Dongni, Blobner, Brandon M., Greer, Phil J., and Lafyatis, Robert

Published
2023
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19. T1 signal intensity ratio of the pancreas as an imaging biomarker for the staging of chronic pancreatitis

Author

Tirkes, Temel, Dasyam, Anil K., Shah, Zarine K., Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Chang, Stephanie T., Farinas, Carlos A., Grajo, Joseph R., Mawad, Kareem, Takahashi, Naoki, Venkatesh, Sudhakar K., Wachsman, Ashley, Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Van Den Eeden, Stephen K., Yang, Yunlong, Topazian, Mark, Andersen, Dana K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2022
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22. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Author

AlKaade, Samer, Amann, Stephen T., Anderson, Michelle A., Banks, Peter, Conwell, Darwin, Brand, Randall E., Cote, Gregory A., Romagnuolo, Joseph, Forsmark, Christopher E., Gardner, Timothy, Gelrud, Andres, Guda, Nalini, Lewis, Michele, Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh, Wilcox, C. Mel, Yadav, Dhiraj, Whitcomb, David C., Tang, Gong, Slivka, Adam, and Bellin, Melena

Published
2023
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23. Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design

Author

Yadav, Dhiraj, primary, Conwell, Darwin L., additional, Pandol, Stephen J., additional, Steen, Hanno, additional, Feng, Ziding, additional, Li, Liang, additional, Andersen, Dana, additional, Bellin, Melena, additional, Chari, Suresh T., additional, Cruz-Monserrate, Zobeida, additional, Fisher, William E., additional, Fogel, Evan L., additional, Forsmark, Christopher E., additional, Hart, Phil A., additional, Lesinski, Gregory B., additional, Park, Walter G., additional, Rinaudo, Jo Ann, additional, Saloman, Jami L., additional, Serrano, Jose, additional, Tirkes, Temel, additional, Topazian, Mark D., additional, van Den Eeden, Stephen, additional, Vege, Santhi Swaroop, additional, and Whitcomb, David C., additional

Published
2024
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25. SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial: Rationale, Methodology, and Potential Implications.

Author

Coté, Gregory A, Durkalski-Mauldin, Valerie L, Serrano, Jose, Klintworth, Erin, Williams, April W, Cruz-Monserrate, Zobeida, Arain, Mustafa, Buxbaum, James L, Conwell, Darwin L, Fogel, Evan L, Freeman, Martin L, Gardner, Timothy B, van Geenen, Erwin, Groce, J Royce, Jonnalagadda, Sreenivasa S, Keswani, Rajesh N, Menon, Shyam, Moffatt, Dana C, Papachristou, Georgios I, Ross, Andrew, Tarnasky, Paul R, Wang, Andrew Y, Wilcox, C Mel, Hamilton, Frank, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Prevention, Digestive Diseases, Clinical Research, Oral and gastrointestinal, Adult, Cholangiopancreatography, Endoscopic Retrograde, Cholangiopancreatography, Magnetic Resonance, Cohort Studies, Endosonography, Female, Humans, Internationality, Male, Outcome Assessment, Health Care, Pancreas, Pancreatitis, Recurrence, Risk Factors, Secondary Prevention, Sphincterotomy, Endoscopic, acute pancreatitis, acute recurrent pancreatitis, chronic pancreatitis, endoscopic retrograde cholangiopancreatography, pancreas divisum, SHARP Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesIn patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this study are to describe the rationale and methodology of a sham-controlled clinical trial designed to test the hypothesis that miES reduces the risk of acute pancreatitis.MethodsThe SpHincterotomy for Acute Recurrent Pancreatitis (SHARP) trial is a multicenter, international, sham-controlled, randomized trial comparing endoscopic ultrasound + ERCP with miES versus endoscopic ultrasound + sham for the management of ARP. A total of 234 consented patients having 2 or more discrete episodes of acute pancreatitis, pancreas divisum confirmed by magnetic resonance cholangiopancreatography, and no other clear etiology for acute pancreatitis will be randomized. Both cohorts will be followed for a minimum of 6 months and a maximum of 48 months.ResultsThe trial is powered to detect a 33% risk reduction of acute pancreatitis frequency.ConclusionsThe SHARP trial will determine whether ERCP with miES benefits patients with idiopathic ARP and pancreas divisum. Trial planning has informed the importance of blinded outcome assessors and long-term follow-up.

Published
2019

26. Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Author

Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L, Territo, Paul R, Zhao, Xuandong, Venkatesh, Sudhakar K, Kolipaka, Arunark, Li, Liang, Pisegna, Joseph R, Pandol, Stephen J, Park, Walter G, Topazian, Mark, Serrano, Jose, and Fogel, Evan L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Bioengineering, Biomedical Imaging, Cancer, Clinical Research, Digestive Diseases, Pancreatic Cancer, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Oral and gastrointestinal, Chronic Disease, Fibrosis, Humans, Magnetic Resonance Imaging, Multicenter Studies as Topic, Pancreatitis, United States, Chronic pancreatitis, MRI, MRCP, T-1 mapping, Extracellular volume, Diffusion-weighted imaging, MR elastography, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, T 1 mapping, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T1-weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T1 relaxometry, ECV, T1-weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

Published
2019

27. Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus

Author

Goodarzi, Mark O, Nagpal, Tanvi, Greer, Phil, Cui, Jinrui, Chen, Yii-Der I, Guo, Xiuqing, Pankow, James S, Rotter, Jerome I, Alkaade, Samer, Amann, Stephen T, Baillie, John, Banks, Peter A, Brand, Randall E, Conwell, Darwin L, Cote, Gregory A, Forsmark, Christopher E, Gardner, Timothy B, Gelrud, Andres, Guda, Nalini, LaRusch, Jessica, Lewis, Michele D, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Romagnuolo, Joseph, Sandhu, Bimaljit S, Sherman, Stuart, Singh, Vikesh K, Wilcox, C Mel, Pandol, Stephen J, Park, Walter G, Andersen, Dana K, Bellin, Melena D, Hart, Phil A, Yadav, Dhiraj, and Whitcomb, David C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Clinical Research, Diabetes, Genetics, Genetic Testing, Metabolic and endocrine, Aged, Case-Control Studies, Comorbidity, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Genotype, Humans, Male, Middle Aged, Pancreatitis, Chronic, Polymorphism, Single Nucleotide, Risk Factors, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical sciences
Abstract

IntroductionDiabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.MethodsWe used 60 T2DM single nucleotide polymorphisms to construct a weighted GRS in 1,613 subjects from the North American Pancreatitis Study 2 and 2,685 subjects from the Multi-Ethnic Study of Atherosclerosis, all of European origin.ResultsThe mean GRS was identical between 321 subjects with CP-DM and 423 subjects with T2DM (66.53 vs 66.42, P = 0.95), and the GRS of both diabetic groups was significantly higher than that of nondiabetic controls (n = 3,554, P < 0.0001). Exploratory analyses attempting to enrich the CP-DM group for pancreatogenic diabetes, such as eliminating diabetes diagnosed before CP, requiring pancreas-specific comorbidities, or removing those with a family history of diabetes, did not improve the ability of the GRS to distinguish between CP-DM and T2DM.DiscussionRecognizing that we lacked a gold standard to define CP-DM, our study suggests that CP-DM may be a subtype of T2DM, a notion that should be tested in future, large prospective studies.

Published
2019

28. Chronic Pancreatitis

Author

Schwarzenberg, Sarah J, Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C Mel, Whitcomb, David C, Werlin, Steven L, Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K, Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S, Romagnuolo, Joseph, Rhee, Sue, Pohl, John F, Perito, Emily R, Ooi, Chee Y, Nathan, Jaimie D, Muniraj, Thiruvengadam, Morinville, Veronique D, McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K, Lewis, Michele, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Guda, Nalini, Gonska, Tanja, Giefer, Matthew J, Gelrud, Andres, Gariepy, Cheryl E, Gardner, Timothy B, Freedman, Steven D, Forsmark, Christopher E, Fishman, Douglas S, Cote, Gregory A, Conwell, Darwin, Brand, Randall E, Bellin, Melena, Barth, Bradley, Banks, Peter A, Anderson, Michelle A, Amann, Stephen T, Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N, Lowe, Mark E, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Prevention, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Alcohol Drinking, Child, Cohort Studies, Cross-Sectional Studies, Demography, Disease Progression, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, North America, Pancreatitis, Chronic, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Tobacco Smoking, children, diabetes, endoscopy, environmental, genetic, pain, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

ObjectivesThe aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.MethodsDemographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.ResultsAlcohol was a risk in 53% of adults and 1% of children (P

Published
2019

29. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage

Author

Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, and Conwell, Darwin L

Subjects
Digestive Diseases, Cancer, Rare Diseases, Clinical Research, Diabetes, Pancreatic Cancer, Metabolic and endocrine, Biological Specimen Banks, Biomedical Research, Child, Diabetes Mellitus, Guidelines as Topic, Humans, Pancreatic Neoplasms, Pancreatitis, Chronic, Preservation, Biological, Specimen Handling, biorepository, biospecimens, pancreas, standard operating procedures, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.

Published
2018

30. PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Yadav, Dhiraj, Park, Walter G, Fogel, Evan L, Li, Liang, Chari, Suresh T, Feng, Ziding, Fisher, William E, Forsmark, Christopher E, Jeon, Christie Y, Habtezion, Aida, Hart, Phil A, Hughes, Steven J, Othman, Mohamed O, Rinaudo, Jo Ann S, Pandol, Stephen J, Tirkes, Temel, Serrano, Jose, Srivastava, Sudhir, Van Den Eeden, Stephen K, Whitcomb, David C, Topazian, Mark, and Conwell, Darwin L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pancreatic Cancer, Prevention, Digestive Diseases, Rare Diseases, Cancer, Clinical Research, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aetiology, Oral and gastrointestinal, Adult, Biomarkers, Blood Specimen Collection, Diabetes Mellitus, Disease Progression, Humans, Longitudinal Studies, Observational Studies as Topic, Outcome Assessment, Health Care, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Specimen Handling, Translational Research, Biomedical, United States, pancreas, alcohol, tobacco, genetic, biorepository, cohort, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

Published
2018

37. The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry

Author

Paragomi, Pedram, Papachristou, Georgios I., Jeong, Kwonho, Hinton, Alice, Pothoulakis, Ioannis, Talukdar, Rupjyoti, Kochhar, Rakesh, Goenka, Mahesh K., Gulla, Aiste, Gonzalez, Jose A., Singh, Vikesh K., Ferreira Bogado, Miguel, Stevens, Tyler, Barbu, Sorin T., Nawaz, Haq, Gutierrez, Silvia C., Zarnescu, Narcis, Archibugi, Livia, Easler, Jeffrey J., Triantafyllou, Konstantinos, Peláez-Luna, Mario, Thakkar, Shyam, Ocampo, Carlos, de-Madaria, Enrique, Cote, Gregory A., Wu, Bechien U., Lee, Peter J., Hart, Phil A., Conwell, Darwin L., Toledo, Frederico G.S., and Yadav, Dhiraj

Published
2022
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38. Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT

Author

Nathan, Jaimie D., Yang, Yi, Eaton, Anne, Witkowski, Piotr, Wijkstrom, Martin, Walsh, Matthew, Trikudanathan, Guru, Singh, Vikesh K., Schwarzenberg, Sarah J., Pruett, Timothy L., Posselt, Andrew, Naziruddin, Bashoo, Mokshagundam, Sri Prakash, Morgan, Katherine, Lara, Luis F., Kirchner, Varvara, He, Jin, Gardner, Timothy B., Freeman, Martin L., Ellery, Kate, Conwell, Darwin L., Chinnakotla, Srinath, Beilman, Gregory J., Ahmad, Syed, Abu-El-Haija, Maisam, Hodges, James S., and Bellin, Melena D.

Published
2022
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39. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2023
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40. Serum biomarkers for chronic pancreatitis pain patterns

Author

Saloman, Jami L., Tang, Gong, Stello, Kimberly M., Hall, Kristen E., Wang, Xianling, AlKaade, Samer, Banks, Peter A., Brand, Randall E., Conwell, Darwin L., Coté, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Lewis, Michele D., Sherman, Stuart, Slivka, Adam, Whitcomb, David C., and Yadav, Dhiraj

Published
2021
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42. Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Author

Gumpper-Fedus, Kristyn, primary, Crowe, Olivia, additional, Hart, Phil A., additional, Pita-Grisanti, Valentina, additional, Velez-Bonet, Ericka, additional, Belury, Martha A., additional, Ramsey, Mitchell L., additional, Cole, Rachel M., additional, Badi, Niharika, additional, Culp, Stacey, additional, Hinton, Alice, additional, Lara, Luis F., additional, Krishna, Somashekar G., additional, Conwell, Darwin L., additional, and Cruz-Monserrate, Zobeida, additional

Published
2024
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43. Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects

Author

Fogel, Evan L, primary, Easler, Jeffrey J, additional, Yuan, Ying, additional, Yadav, Dhiraj, additional, Conwell, Darwin L, additional, Vege, Santhi Swaroop, additional, Han, Samuel Y, additional, Park, Walter, additional, Patrick, Vanessa, additional, and White, Fletcher A, additional

Published
2024
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46. Diabetes following acute pancreatitis

Author

Hart, Phil A, Bradley, David, Conwell, Darwin L, Dungan, Kathleen, Krishna, Somashekar G, Wyne, Kathleen, Bellin, Melena D, Yadav, Dhiraj, Andersen, Dana K, Serrano, Jose, and Papachristou, Georgios I

Published
2021
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47. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROCEED study.

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2022
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49. Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19

Author

Merchant, Ambreen A., Patel, Vaishali A., Willingham, Field F., Howard, Eric F., West, Mary K., Koza, Casey L., Yachimski, Patrick S., Qayed, Emad, Nustas, Rosemary, Zakaria, Ali, Piper, Marc S., Jaza, Lujain, Forbes, Nauzer, Chau, Millie, Lara, Luis F., Papachristou, Georgios I., Okafor, Uchechi, Conwell, Darwin L., Volk, Michael L., Mosier, Evan, Azab, Mohamed, Patel, Anish, Hilson, Liam G., Zhou, Selena, Buxbaum, James, Kushnir, Vladimir M., Lenyo, Alexandria M., Sloan, Ian P., Hollander, Thomas, McLeod, Caroline G., Spitzer, Rebecca L., Wakefield, Lauren, Nitchie, Haley, Ordiah, Collins O., Rockey, Don C., Alford, Teldon B., Amin, Sunil, Kuftinec, Gabriela N., Deshpande, Amar R., Yadav, Dhiraj, Saul, Melissa, Mays, Melanie, Anderson, Gulsum, Wood, Kelley, Mathews, Laura, Fox, Charlie, Kolb, Jennifer M., Wani, Sachin, Pawa, Swati, Pawa, Rishi, Canakis, Andrew, Huang, Christopher, Jamil, Laith H., Aneese, Andrew M., Gjeorgjievski, V. Mihajlo, Imam, Zaid, Odish, Fadi, Edhi, Ahmed I., Orosey, Molly, Tiwari, Abhinav, Patwardhan, Soumil, Glamour, Benita K., Smith, Zachary L., Hosmer, Amy E., Furey, Nancy, Chak, Amitabh, Hanley, Katherine A., Wood, Jordan, Keswani, Rajesh N., Patel, Harsh K., Shah, Janak N., Agarunov, Emil, Brown, Nicholas G., Patel, Anish A., Sethi, Amrita, Fogel, Evan L., McNulty, Gail, Haseeb, Abdul, Trieu, Judy A., Dixon, Rebekah E., Yang, Jeong Yun, DiMaio, Christopher J., Mendelsohn, Robin B., Calo, Delia, Aroniadis, Olga C., LaComb, Joseph F., Cruz, Lilian, Reykhart, Olga, Sauer, Bryan G., Diakova, Galina, Dang, Duyen T., Piraka, Cyrus R., Shah, Eric D., Caisse, Molly, Zbib, Natalia H., Damianos, John A., Pohl, Heiko, Mitchell, Stephanie, Bronze, Michael S., Condon, Ashwinee, Lenhart, Adrienne, Muthusamy, Raman, Dua, Kulwinder S., Kanagala, Vikram S., Esteban, James, Kamal, Ayesha, Canto, Marcia I., Singh, Vikesh K., Pinto-Sanchez, Maria Ines, Hutchinson, Joy M., Kwon, Richard S., Korsnes, Sheryl J., Waljee, Akbar K., Tang, Weijing, Zhang, Yueyang, Zhu, Ji, Singh, Harminder, Solati, Zahra, Hajidiacos, Nick, Elmunzer, B. Joseph, Wolf, Bethany J., Scheiman, James M., Tierney, William M., and Taylor, Jason R.

Published
2021
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50. Biomarkers of Chronic Pancreatitis: A systematic literature review

Author

Cruz-Monserrate, Zobeida, Gumpper, Kristyn, Pita, Valentina, Hart, Phil A., Forsmark, Christopher, Whitcomb, David C., Yadav, Dhiraj, Waldron, Richard T., Pandol, Stephen, Steen, Hanno, Anani, Vincent, Kanwar, Natasha, Vege, Santhi Swaroop, Appana, Savi, Li, Liang, Serrano, Jose, Rinaudo, Jo Ann S., Topazian, Mark, and Conwell, Darwin L.

Published
2021
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