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13. Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference.

Author

Ho, Chung Shun, Hoad, Kirsten, Cooke, Brian R., Andersen, Trisha, Graham, Peter, van den Berg, Sjoerd A.A., Hartmann, Michaela F., Lo, Clara W.S., Loh, Tze Ping, de Rijke, Yolanda B., van Zelst, Bertrand D., Wudy, Stefan A., Zakaria, Rosita, and Greaves, Ronda F.

Subjects
MASS spectrometry, LIQUID chromatography-mass spectrometry, MASS measurement, STEROIDS
Abstract

Interference from isomeric steroids is a potential cause of disparity between mass spectrometry-based 17-hydroxyprogesterone (17OHP) results. We aimed to assess the proficiency of mass spectrometry laboratories to report 17OHP in the presence of known isomeric steroids. A series of five samples were prepared using a previously demonstrated commutable approach. These samples included a control (spiked to 15.0 nmol/L 17OHP) and four challenge samples further enriched with equimolar concentrations of 17OHP isomers (11α-hydroxyprogesterone, 11β-hydroxyprogesterone, 16α-hydroxyprogesterone or 21-hydroxyprogesterone). These samples were distributed to 38 participating laboratories that reported serum 17OHP results using mass spectrometry in two external quality assurance programs. The result for each challenge sample was compared to the control sample submitted by each participant. Twenty-six laboratories (68 % of distribution) across three continents returned results. Twenty-five laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS), and one used gas chromatography-tandem mass spectrometry to measure 17OHP. The all-method median of the control sample was 14.3 nmol/L, ranging from 12.4 to 17.6 nmol/L. One laboratory had results that approached the lower limit of tolerance (minus 17.7 % of the control sample), suggesting the isomeric steroid caused an irregular result. Most participating laboratories demonstrated their ability to reliably measure 17OHP in the presence of the four clinically relevant isomeric steroids. The performance of the 12 (32 %) laboratories that did not engage in this activity remains unclear. We recommend that all laboratories offering LC-MS/MS analysis of 17OHP in serum, plasma, or dried bloodspots determine that the isomeric steroids are appropriately separated. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference

Author

Ho, Chung Shun, primary, Hoad, Kirsten, additional, Cooke, Brian R., additional, Andersen, Trisha, additional, Graham, Peter, additional, van den Berg, Sjoerd A.A., additional, Hartmann, Michaela F., additional, Lo, Clara W.S., additional, Loh, Tze Ping, additional, de Rijke, Yolanda B., additional, van Zelst, Bertrand D., additional, Wudy, Stefan A., additional, Zakaria, Rosita, additional, and Greaves, Ronda F., additional

Published
2023
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17. The Australian National Rabbit Database : 50 yr of population monitoring of an invasive species

Author

Roy-Dufresne, Emilie, Lurgi, Miguel, Brown, Stuart C., Wells, Konstans, Cooke, Brian, Mutze, Greg, Peacock, David, Cassey, Phill, Berman, Dave, Brook, Barry W., Campbell, Susan, Cox, Tarnya, Daly, Joanne, Dunk, Iain, Elsworth, Peter, Fletcher, Don, Forsyth, David M., Hocking, Greg, Kovaliski, John, Leane, Michael, Low, Bill, Kennedy, Malcolm, Matthews, John, Mcphee, Steve, MELLIN, CAMILLE, Mooney, Trish, Moseby, Katherine, Read, John, Richardson, Barry J., Schneider, Kathryn, Schwarz, Eric, Sinclair, Ronald, Strive, Tanja, Triulcio, Frank, West, Peter, Saltré, Frederik, and Fordham, Damien A.

Published
2019

25. The LEAP Checklist for Laboratory Evaluation and Analytical Performance Characteristics Reporting of Clinical Measurement Procedures.

Author

Tze Ping Loh, Cooke, Brian R., Thi Chi Mai Tran, Markus, Corey, Zakaria, Rosita, Chung Shun Ho, Theodorsson, Elvar, and Greaves, Ronda F.

Subjects
CHEMICAL laboratories, CLINICAL chemistry, CLINICAL pathology, PATHOLOGICAL laboratories, INTERNATIONAL organization
Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the Laboratory Evaluation and Analytical Performance Characteristics (LEAP) checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures.

Author

Loh, Tze Ping, Cooke, Brian R, Tran, Thi Chi Mai, Markus, Corey, Zakaria, Rosita, Ho, Chung Shun, Theodorsson, Elvar, and Greaves, Ronda F

Subjects
*PATHOLOGICAL laboratories, *CHEMICAL laboratories, *CLINICAL pathology, *CLINICAL chemistry, *INTERNATIONAL organization, *EVALUATION methodology
Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the LEAP checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners. [ABSTRACT FROM AUTHOR]

Published
2024
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27. The marmoset as a potential surrogate for human in drug development

Author

Cooke, Brian Roger

Subjects
615.1
Abstract

The marmoset monkey (Callithrix jacchus) has been used as a non-rodent species in non-clinical development studies for a number of years. However, there is only limited information available on the drug-metabolising enzymes in this species. This study determined the marmoset liver microsomal kinetic parameters (Km and Vmax) for the following activities: 7-ethoxyresorufin O-deethylase, S-mephenytoin N- demethylase, tolbutamide methylhydroxylase, debrisoquine hydroxylase, lauric acid 11-hydroxylase, testosterone 6B-hydroxylase and lauric acid 12-hydroxylase. These activities, which are indicative of the presence of specific cytochrome P450s expressed in the human liver, were evaluated in marmoset liver microsomes to investigate possible similarities between the two species. The metabolism of the human CYP2D6 probe substrate debrisoquine was investigated further, using marmoset liver microsomes and a combination of techniques including HPLC-RAM, LC-MS/MS and NMR. Debrisoquine was metabolised by marmoset liver microsomes to a number of hydroxylated products, including a previously unidentified 6,7-dihydroxydebrisoquine. Interestingly, the major marmoset hepatic metabolite appeared to be 7-hydroxydebrisoquine rather than 4-hydroxydebrisoquine, as is the case in human. The expression of CYP enzymes in marmoset liver was investigated by Western blot analysis of microsomal protein and compared by parallel analysis to liver microsomal protein of male human donors and male Sprague-Dawley rats, using anti-CYP antibodies primarily raised against the human enzyme. The analyses revealed extensive expression of: CYP2C19, CYP2E1, CYP3A4 and CYP3A5 in marmoset, CYP2C9 and CYP2E1 in human, and CYP2A6 and CYP2E1 in rat. There was little or no expression of proteins detected by antibodies raised against CYP2A6 and CYP2D6 in marmoset, CYP2B6 in human and CYP2B6, CYP2D6 and CYP3A5 in rat. Finally, Inter-species comparison of CYP expression between human and marmoset was examined at the genetic level. Primers and probes were selected to specifically match human CYP mRNA, and then used to determine sequence identity between the human hepatic CYPs and their marmoset counterparts. These analyses established a species comparison for CYP2B6, with the primer and probe targeted binding region within the marmoset enzyme being identical (or very similar) to that of the human protein.

Published
2010

28. Institutional Advancement: Using the Malcolm Baldrige National Quality Award Criteria for Self-Study and Accreditation.

Author

Cooke, Brian

Abstract

The criteria used for the Malcolm Baldrige National Quality Award can provide community colleges with a strategic tool for college planning, management, assessment, and accreditation. The Criteria focus on two measurable objectives for institutional effectiveness: the delivery of educational value to current and future students through instruction and support services that contribute to students' overall development and the improvement of overall college effectiveness, use of resources, and capabilities for sustainable performance. In addition, the Criteria are non-prescriptive, encouraging colleges to develop creative approaches; are comprehensive, representing a unifying framework emphasizing interdependence; emphasize the alignment of efforts throughout the college; and encourage planned change and continual improvement. Baldrige-based schools demonstrate excellence in leadership, information and analysis, strategic and operational planning, human resource development and management, educational and business process management, college performance results, and student focus and student stakeholder satisfaction. The following steps are suggested for initiating a Baldrige-based approach to institutional advancement: (1) organize an orientation for the college President's Cabinet or senior management team; (2) form and train an institutional Baldrige team; (3) establish linkages between institutional strategic planning and Baldrige-based initiatives; (4) identify the needs of current and future students and stakeholders; (5) assess current institutional strengths and weaknesses; and (6) review findings with the President's Cabinet and the senior management team. (TGI)

Published
1996

29. A Quality Classroom: Quality Teaching Tools That Facilitate Student Success.

Author

Cooke, Brian

Abstract

This presentation described practical applications and quality tools for educators that are based on original classroom research and the theories of motivation, learning, profound knowledge, systems thinking, and service quality advanced by Karl Albrecht, William Glasser, and W. Edwards Deming. The presentation was conducted in a way that demonstrated the classroom methodology and quality teaching practices. Tools described were: (1) a flow chart which helps students visualize and understand basic instructional objectives and expectations; (2) an affinity diagram which organizes output from a brainstorming session, generates, organizes, and consolidates information, and helps an improvement team develop its ideas and collective thoughts about an issue or task; (3) a moment-of-truth chart which defines students' expectations both for the instructor and for themselves and focuses attention on specific services necessary to meet or exceed customer expectations; (4) process metrics which help the instructor and students assess the quality of each class meeting for purposes of continuous improvement; (5) a consensogram which is a quick, confidential tool to inventory and assess a group's level of understanding, agreement, or commitment; and (6) a run chart which is a line graph that focuses on trends in service. The paper includes copies of a deployment flow chart, an affinity diagram, moment of truth charts (student, instructor), consensogram, and run charts. (JB)

Published
1995

30. Rethinking Teaching and Testing: Quality in the Classroom.

Author

Cooke, Brian P.

Abstract

Changes in the way contemporary organizations conduct business demand a concurrent redesign of teaching and testing methods. Maintaining instructional quality must begin with knowledge of the quality revolution in contemporary organizations in order to meet the demands of these organizations for self-confident, self-directed, self-motivated, team-oriented, quality-sensitive, and customer-directed employees. Teachers must assure the complementary development of student interest, appreciation, pride of workmanship, and skills in learning, constant improvement, leadership, and collaboration. In a quality classroom, the teacher and students share responsibility for learning course content and for developing thinking, judgment, and interpersonal communication. Quality teachers envision and manage their classrooms as exemplary organizations, and minimize student fear and competitiveness. At Santa Fe Community College, in New Mexico, instructors have been teaching and testing students with an emphasis on principles of collaboration and continuous quality improvement (CQI). The CQI approach to objective testing begins with a class discussion of the demand for collaborative work in contemporary organizations, explains the linkages between collaborative learning and future employment opportunities, and evaluates students both on their individual and collaborative knowledge. After tests are taken by both individuals and teams, the instructor notes the most frequently misunderstood questions to identify the "significant few" learning points that need continued instruction. Data collected in a recent Business and Management course indicate that this quality testing approach delivers measurable improvement in student learning as defined by continuous improvement on unit tests. Student responses further substantiate the merit of quality teaching and learning processes. (AC)

Published
1994

31. Reinventing Teaching and Testing: Quality Learning for Quality Employment.

Author

Cooke, Brian P.

Abstract

To succeed in today's competitive global markets, organizations are hiring responsible problem solvers and collaborative "associates" who improve productivity, assure quality service, and contribute creatively. These organizations demand employees who are skilled at learning to learn, listening, communicating, problem solving, teamwork, and leadership. The dramatic shift in the way employers conduct business demands the concurrent redesign of antiquated teaching and testing emphases in colleges. Teachers committed to preparing students for professional and vocational opportunities must share employers' emphasis on constant improvement, leadership, pride in workmanship, and price-based decision making. The dual emphasis on course content and learning process is essential in a global economy where the breadth of professional and technical information defies individual mastery and demands collaboration. Quality teachers reward learning and deemphasize test scores. At Santa Fe Community College in New Mexico, many instructors teach students using quality management principles, administering traditional multiple-choice and true-false tests in three stages. In stage one, instructors collect completed tests and record only how many questions each student answered correctly. In stage two, students are invited to find their own errors and to re-submit their answers for further evaluation. In stage three, students form teams of up to five members and complete the same test as a group, developing skills associated with group problem solving. In evaluations, students in these quality classrooms express greater comprehension and self-confidence. (PAA)

Published
1993

34. The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures.

Author

Loh, Tze Ping, Cooke, Brian R., Tran, Thi Chi Mai, Markus, Corey, Zakaria, Rosita, Ho, Chung Shun, Theodorsson, Elvar, and Greaves, Ronda F.

Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the LEAP checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners. [ABSTRACT FROM AUTHOR]

Published
2023
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40. The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures.

Author

Tze Ping Loh, Cooke, Brian R., Thi Chi Mai Tran, Markus, Corey, Zakaria, Rosita, Chung Shun Ho, Theodorsson, Elvar, and Greaves, Ronda F.

Subjects
*CHEMICAL laboratories, *CLINICAL pathology, *CLINICAL chemistry, *PATHOLOGICAL laboratories, *INTERNATIONAL organization
Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the Laboratory Evaluation and Analytical Performance Characteristics (LEAP) checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners. [ABSTRACT FROM AUTHOR]

Published
2023
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46. A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

Author

Chan, Jo-Anne, Howell, Katherine B., Langer, Christine, Maier, Alexander G., Hasang, Wina, Rogerson, Stephen J., Petter, Michaela, Chesson, Joanne, Stanisic, Danielle I., Duffy, Michael F., Cooke, Brian M., Siba, Peter M., Mueller, Ivo, Bull, Peter C., Marsh, Kevin, Fowkes, Freya J.I., and Beeson, James G.

Published
2016
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