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4. Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer

Author

Shaw, Jacqueline A., Page, Karen, Wren, Evie, de Bruin, Elza C., Kalashnikova, Ekaterina, Hastings, Robert, McEwen, Rob, Zhang, Eddie, Wadsley, Marc, Acheampong, Emmanuel, Renner, Derrick, Gleason, Kelly L.T., Ambasager, Bana, Stetson, Daniel, Fernandez-Garcia, Daniel, Guttery, David, Allsopp, Rebecca C., Rodriguez, Angel, Zimmermann, Bernhard, Sethi, Himanshu, Aleshin, Alexey, Liu, Minetta C., Richards, Cathy, Stebbing, Justin, Ali, Simak, Rehman, Farah, Cleator, Susan, Kenny, Laura, Ahmed, Samreen, Armstrong, Anne C., and Coombes, R. Charles

Published
2024
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5. Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Author

Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, and Krebs, Matthew G.

Published
2023
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6. Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Author

Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, and Krebs, Matthew G.

Published
2023
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8. Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

Author

Lam Eric, Stavropoulou Alexandra V, Alao John P, and Coombes R Charles

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Histone deacetylase inhibitors (HDACIs) have been shown to induce apoptotic and autophagic cell death in vitro and in vivo. The molecular mechanisms that underlie these cytotoxic effects are not yet clearly understood. Recently, HDACIs were shown to induce Akt dephosphorylation by disrupting HDAC-protein phosphatase 1 (PP1) complexes. This disruption results in the increased association of PP1 with Akt, resulting in the dephosphorylation and consequent inactivation of the kinase. Akt enhances cellular survival through the phosphorylation-dependent inhibition of several pro-apoptotic proteins. Akt is an important negative regulator of GSK3β, a kinase that has been shown to regulate apoptosis in response to various stimuli. In the present study, we investigated the role of GSK3β in mediating the cytotoxic effects in MCF-7 breast cancer cells treated with trichostatin A (TSA), a prototype HDACI. We show that TSA induces Akt dephosphorylation in a PP1-dependent manner, resulting in activation of GSK3β in MCF-7 cells. Similarly, knockdown of HDAC1 and-2 by small interfering RNA (siRNA) resulted in the dephosphorylation of Akt and GSK3β. Selective inhibition of GSK3β attenuated TSA induced cytotoxicity and resulted in enhanced proliferation following drug removal. Our findings identify GSK3β as an important mediator of TSA-induced cytotoxicity in MCF-7 breast cancer cells.

Published
2006
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9. The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

Author

Coombes R Charles, Lam Eric, Pomeranz Karen M, Stavropoulou Alexandra V, Gamble Simon C, Alao John P, and Vigushin David M

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the activity of cyclin D1 may be regulated through its cytoplasmic sequestration. We have demonstrated previously, that TSA induces the ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells. Additional studies were initiated in order to further investigate the effect of TSA on cyclin D1 regulation using sub-cellular fractionation techniques. Results Our studies revealed cyclin D1 to be localized predominantly within the cytoplasmic fraction of all cell lines tested. These observations were confirmed by confocal microscopy. GSK3β was found to be localized within both the nucleus and cytoplasm throughout the cell cycle. Inhibition of GSK3β or CRM1-dependent nuclear export resulted in only modest nuclear accumulation, suggesting that the cytoplasmic localization of cyclin D1 results from the inhibition of its nuclear import. Conclusion We have shown by several different experimental approaches, that cyclin D1 is in fact a predominantly cytoplasmic protein in mammalian cancer cell lines. Recent studies have shown that the cytoplasmic sequestration of cyclin D1 prevents apoptosis in neuronal cells. Our results suggest that cytoplasmic sequestration may additionally serve to regulate cyclin D1 activity in mammalian cancer cells.

Published
2006
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11. Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer

Author

Harrod, Alison, Lai, Chun-Fui, Goldsbrough, Isabella, Simmons, Georgia M., Oppermans, Natasha, Santos, Daniela B., Győrffy, Balazs, Allsopp, Rebecca C., Toghill, Bradley J., Balachandran, Kirsty, Lawson, Mandy, Morrow, Christopher J., Surakala, Manasa, Carnevalli, Larissa S., Zhang, Pei, Guttery, David S., Shaw, Jacqueline A., Coombes, R. Charles, Buluwela, Lakjaya, and Ali, Simak

Published
2022
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14. Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients

Author

Nteliopoulos, Georgios, Page, Karen, Hills, Allison, Howarth, Karen, Emmett, Warren, Green, Emma, Martinson, Luke J., Fernadez-Garcia, Daniel, Hastings, Robert, Guttery, David S., Kenny, Laura, Stebbing, Justin, Cleator, Susan, Rehman, Farah, Gleason, Kelly L. T., Sanela, Andrijac, Ion, Charlotte, Rushton, Amelia J., Rosenfeld, Nitzan, Coombes, R. Charles, and Shaw, Jacqueline A.

Published
2021
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20. The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation

Author

Alexandrou, George, primary, Mantikas, Katerina-Theresa, additional, Allsopp, Rebecca, additional, Yapeter, Calista Adele, additional, Jahin, Myesha, additional, Melnick, Taryn, additional, Ali, Simak, additional, Coombes, R. Charles, additional, Toumazou, Christofer, additional, Shaw, Jacqueline A., additional, and Kalofonou, Melpomeni, additional

Published
2023
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23. A framework for the development of effective anti-metastatic agents

Author

Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., and Ritchie, James W. A.

Published
2019
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24. A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation

Author

Kalofonou, Melpomeni, Malpartida-Cardenas, Kenny, Alexandrou, George, Rodriguez-Manzano, Jesus, Yu, Ling-Shan, Miscourides, Nicholas, Allsopp, Rebecca, Gleason, Kelly L. T., Goddard, Katie, Fernandez-Garcia, Daniel, Page, Karen, Georgiou, Pantelis, Ali, Simak, Coombes, R. Charles, Shaw, Jacqueline, and Toumazou, Christofer

Published
2020
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26. Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease

Author

Page, Karen, Martinson, Luke J., Fernandez-Garcia, Daniel, Hills, Allison, Gleason, Kelly L. T., Gray, Molly C., Rushton, Amelia J., Nteliopoulos, Georgios, Hastings, Robert K., Goddard, Kate, Ions, Charlotte, Parmar, Vilas, Primrose, Lindsay, Openshaw, Mark R., Guttery, David S., Palmieri, Carlo, Ali, Simak, Stebbing, Justin, Coombes, R. Charles, and Shaw, Jacqueline A.

Published
2021
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31. Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Author

Nguyen, Van T. M., Barozzi, Iros, Faronato, Monica, Lombardo, Ylenia, Steel, Jennifer H., Patel, Naina, Darbre, Philippa, Castellano, Leandro, Győrffy, Balázs, Woodley, Laura, Rodriguez-Meira, Alba, Patten, Darren K., Vircillo, Valentina, Periyasamy, Manikandan, Ali, Simak, Frige, Gianmaria, Minucci, Saverio, Coombes, R. Charles, and Magnani, Luca

Published
2019
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32. Data from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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33. Supplementary Figure S7. from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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35. Supplementary Information from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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37. Supplementary Tables 1-4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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38. Table S4 from SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer

Author

Zwart, Wilbert, primary, Flach, Koen D., primary, Rudraraju, Bharath, primary, Abdel-Fatah, Tarek M.A., primary, Gojis, Ondrej, primary, Canisius, Sander, primary, Moore, David, primary, Nevedomskaya, Ekaterina, primary, Opdam, Mark, primary, Droog, Marjolein, primary, Hofland, Ingrid, primary, Chan, Steve, primary, Shaw, Jacqui, primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, Carroll, Jason S., primary, Ali, Simak, primary, and Palmieri, Carlo, primary

Published
2023
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40. Supplementary Table 1 from [18F]-3′Deoxy-3′-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel

Author

Contractor, Kaiyumars B., primary, Kenny, Laura M., primary, Stebbing, Justin, primary, Rosso, Lula, primary, Ahmad, Rizvana, primary, Jacob, Jimmy, primary, Challapalli, Amarnath, primary, Turkheimer, Federico, primary, Al-Nahhas, Adil, primary, Sharma, Rohini, primary, Coombes, R. Charles, primary, and Aboagye, Eric O., primary

Published
2023
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41. Supplementary Figure 4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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42. Supplemtary Figures S 1-14 from SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer

Author

Zwart, Wilbert, primary, Flach, Koen D., primary, Rudraraju, Bharath, primary, Abdel-Fatah, Tarek M.A., primary, Gojis, Ondrej, primary, Canisius, Sander, primary, Moore, David, primary, Nevedomskaya, Ekaterina, primary, Opdam, Mark, primary, Droog, Marjolein, primary, Hofland, Ingrid, primary, Chan, Steve, primary, Shaw, Jacqui, primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, Carroll, Jason S., primary, Ali, Simak, primary, and Palmieri, Carlo, primary

Published
2023
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43. Supplementary Table 1 from Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast Cancer

Author

Patel, Hetal, primary, Abduljabbar, Rezvan, primary, Lai, Chun-Fui, primary, Periyasamy, Manikandan, primary, Harrod, Alison, primary, Gemma, Carolina, primary, Steel, Jennifer H., primary, Patel, Naina, primary, Busonero, Claudia, primary, Jerjees, Dena, primary, Remenyi, Judit, primary, Smith, Sally, primary, Gomm, Jennifer J., primary, Magnani, Luca, primary, Győrffy, Balázs, primary, Jones, Louise J., primary, Fuller-Pace, Frances, primary, Shousha, Sami, primary, Buluwela, Laki, primary, Rakha, Emad A., primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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44. Supplementary Figure 6 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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45. Supplementary Figure 1 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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46. Supplementary Figure 2 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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48. Supplementary Figures from Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast Cancer

Author

Patel, Hetal, primary, Abduljabbar, Rezvan, primary, Lai, Chun-Fui, primary, Periyasamy, Manikandan, primary, Harrod, Alison, primary, Gemma, Carolina, primary, Steel, Jennifer H., primary, Patel, Naina, primary, Busonero, Claudia, primary, Jerjees, Dena, primary, Remenyi, Judit, primary, Smith, Sally, primary, Gomm, Jennifer J., primary, Magnani, Luca, primary, Győrffy, Balázs, primary, Jones, Louise J., primary, Fuller-Pace, Frances, primary, Shousha, Sami, primary, Buluwela, Laki, primary, Rakha, Emad A., primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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49. Supplementary Data from Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts

Author

Shaw, Jacqueline A., primary, Guttery, David S., primary, Hills, Allison, primary, Fernandez-Garcia, Daniel, primary, Page, Karen, primary, Rosales, Brenda M., primary, Goddard, Kate S., primary, Hastings, Robert K., primary, Luo, Jinli, primary, Ogle, Olivia, primary, Woodley, Laura, primary, Ali, Simak, primary, Stebbing, Justin, primary, and Coombes, R. Charles, primary

Published
2023
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50. Supplementary Figure 3 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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