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1,715 results on '"Copeland, Neal G."'

5. A recellularized human colon model identifies cancer driver genes

Author

Chen, Huanhuan Joyce, Wei, Zhubo, Sun, Jian, Bhattacharya, Asmita, Savage, David J, Serda, Rita, Mackeyev, Yuri, Curley, Steven A, Bu, Pengcheng, Wang, Lihua, Chen, Shuibing, Cohen-Gould, Leona, Huang, Emina, Shen, Xiling, Lipkin, Steven M, Copeland, Neal G, Jenkins, Nancy A, and Shuler, Michael L

Published
2016

7. Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

Author

Vu, Hong Nhung, primary, Valdimarsson, Matti Már, additional, Sigurbjörnsdóttir, Sara, additional, Bergsteinsdóttir, Kristín, additional, Debbache, Julien, additional, Bismuth, Keren, additional, Swing, Deborah A., additional, Hallsson, Jón H., additional, Larue, Lionel, additional, Arnheiter, Heinz, additional, Copeland, Neal G., additional, Jenkins, Nancy A., additional, Heidarsson, Petur O., additional, and Steingrímsson, Eiríkur, additional

Published
2023
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14. Sleeping Beautytransposon mutagenesis in mouse intestinal organoids identifies genes involved in tumor progression and metastasis

Author

Iida, Naoko, Muranaka, Yukari, Park, Jun Won, Sekine, Shigeki, Copeland, Neal G., Jenkins, Nancy A., Shiraishi, Yuichi, Oshima, Masanobu, and Takeda, Haruna

Abstract

To identify genes important for colorectal cancer (CRC) development and metastasis, we established a new metastatic mouse organoid model using Sleeping Beauty(SB) transposon mutagenesis. Intestinal organoids derived from mice carrying actively mobilizing SB transposons, an activating KrasG12D, and an inactivating ApcΔ716allele, were transplanted to immunodeficient mice. While 66.7% of mice developed primary tumors, 7.6% also developed metastatic tumors. Analysis of SB insertion sites in tumors identified numerous candidate cancer genes (CCGs) identified previously in intestinal SB screens performed in vivo, in addition to new CCGs, such as Slit2and Atxn1. Metastatic tumors from the same mouse were clonally related to each other and to primary tumors, as evidenced by the transposon insertion site. To provide functional validation, we knocked out Slit2, Atxn1, and Cdkn2ain mouse tumor organoids and transplanted to mice. Tumor development was promoted when these gene were knocked out, demonstrating that these are potent tumor suppressors. Cdkn2aknockout cells also metastasized to the liver in 100% of the mice, demonstrating that Cdkn2aloss confers metastatic ability. Our organoid model thus provides a new approach that can be used to understand the evolutionary forces driving CRC metastasis and a rich resource to uncover CCGs promoting CRC.

Published
2024
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22. Angiopoietins 3 and 4: Diverging Gene Counterparts in Mice and Humans

Author

Valenzuela, David M., Griffiths, Jennifer A., Rojas, Jose, Aldrich, Thomas H., Jones, Pamela F., Zhou, Hao, McClain, Joyce, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Huang, Tammy, Papadopoulos, Nick, Maisonpierre, Peter C., Davis, Samuel, and Yancopoulos, George D.

Published
1999

26. p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

Author

Short, Sarah P., Kondo, Jumpei, Smalley-Freed, Whitney G., Takeda, Haruna, Dohn, Michael R., Powell, Anne E., Carnahan, Robert H., Washington, Mary K., Tripathi, Manish, Payne, D. Michael, Jenkins, Nancy A., Copeland, Neal G., Coffey, Robert J., and Reynolds, Albert B.

Subjects
Apoptosis -- Analysis, Cancer -- Development and progression -- Analysis, Gene mutation -- Research, Transcription factors -- Research, Health care industry
Abstract

p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Ape-sensitized mouse models of intestinal cancer, we have identified p120 as an 'obligatory' haploinsufficient tumor suppressor. Whereas monoallelic loss of p120 was associated with a significant increase in tumor multiplicity, loss of both alleles was never observed in tumors from these mice. Moreover, forced ablation of the second allele did not further enhance tumorigenesis, but instead induced synthetic lethality in combination with Ape loss of heterozygosity. In tumor-derived organoid cultures, elimination of both p120 alleles resulted in caspase-3-dependent apoptosis that was blocked by inhibition of Rho kinase (ROCK). With ROCK inhibition, however, p120-ablated organoids exhibited a branching phenotype and a substantial increase in cell proliferation. Access to data from Sleeping Beauty mutagenesis screens afforded an opportunity to directly assess the tumorigenic impact of p120 haploinsufficiency relative to other candidate drivers. Remarkably, p120 ranked third among the 919 drivers identified. Cofactors [alpha]-catenin and epithelial cadherin (E-cadherin) were also among the highest scoring candidates, indicating a mechanism at the level of the intact complex that may play an important role at very early stages of of intestinal tumorigenesis while simultaneously restricting outright loss via synthetic lethality., Introduction The vast majority of human colorectal cancer (CRC) is triggered by inactivation of the tumor suppressor adenomatous polyposis coli (APC) in one of several intestinal stem cells (ISCs) present [...]

Published
2017
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28. S. Table 2 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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29. S Table 5 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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30. S Table 1 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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31. Supplementary Data from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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32. Data from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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33. cohort_primary from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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34. S Table 4 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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35. S Table 3 from Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma

Author

Kodama, Michiko, primary, Shimura, Hiroko, primary, Tien, Jean C., primary, Newberg, Justin Y., primary, Kodama, Takahiro, primary, Wei, Zhubo, primary, Rangel, Roberto, primary, Yoshihara, Kosuke, primary, Kuruma, Airi, primary, Nakae, Aya, primary, Hashimoto, Kae, primary, Sawada, Kenjiro, primary, Kimura, Tadashi, primary, Jenkins, Nancy A., primary, and Copeland, Neal G., primary

Published
2023
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39. Data from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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44. Supplementary Table 3 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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45. Supplementary Figure 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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46. Supplementary Table 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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50. Supplementary Table 1 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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