1. Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer
- Author
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Aboagye, E, Lu, H, Lou, H, Wengert, G, Paudel, R, Patel, N, Desai, S, Crum, W, Linton-Reid, K, Chen, M, Li, D, Ip, J, Mauri, F, Pinato, DJ, Rockall, A, Copley, SJ, and Ghaem-Maghami, S
- Abstract
Tertiary lymphoid structure (TLS) is associated with prognosis in copy number-driven tumours, including high grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC is not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression free survival. We show that presence of TLS in HGSOC tumours is associated with B-cell maturation and cytotoxic tumourspecific T-cells activation and proliferation. Additionally, the copy number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Manuscript Click here to view linked References Lastly, a radiomics-based signature is developed to predict presence of TLS, which independently predicts PFS in both HGSOC patients and ICI-treated NSCLC patients. Overall, we reveal that TLS coordinates intratumoural B-cell and T-cell response against HGSOC tumour, while cancer genome evolves to counteract TLS formation and function.
- Published
- 2023