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945 results on '"Coppa P"'

1. Bioarchaeology aids the cultural understanding of six characters in search of their agency (Tarquinia, ninth–seventh century BC, central Italy)

Author

Bagnasco, G., Marzullo, M., Cattaneo, C., Biehler-Gomez, L., Mazzarelli, D., Ricciardi, V., Müller, W., Coppa, A., McLaughlin, R., Motta, L., Prato, O., Schmidt, F., Gaveriaux, F., Marras, G. B., Millet, M. A., Madgwick, R., Ballantyne, R., Makarewicz, C.A., Trentacoste, A., Reimer, P., Mattiangeli, V., Bradley, D. G., Malone, C., Esposito, C., Breslin, E. M., and Stoddart, S.

Published
2024
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2. The Born Oscillator

Author

Coppa, Gianni

Subjects
Quantum Physics
Abstract

The paper studies the properties of an oscillator whose Hamiltonian is $[(1+q^2)(1+p^2)]^{1/2}-1$. It can be deduced from the nonlinear theory of electrodynamics originally proposed by Max Born in 1934. The quantization of such oscillator represents a possible regularization of the Barry and Keating's Hamiltonian, which has been proposed in the framework of the theory of non-trivial zeros of the Riemann's $\zeta$ function.

Published
2023

3. Population genomics of post-glacial western Eurasia

Author

Allentoft, Morten E, Sikora, Martin, Refoyo-Martínez, Alba, Irving-Pease, Evan K, Fischer, Anders, Barrie, William, Ingason, Andrés, Stenderup, Jesper, Sjögren, Karl-Göran, Pearson, Alice, Sousa da Mota, Bárbara, Schulz Paulsson, Bettina, Halgren, Alma, Macleod, Ruairidh, Jørkov, Marie Louise Schjellerup, Demeter, Fabrice, Sørensen, Lasse, Nielsen, Poul Otto, Henriksen, Rasmus A, Vimala, Tharsika, McColl, Hugh, Margaryan, Ashot, Ilardo, Melissa, Vaughn, Andrew, Fischer Mortensen, Morten, Nielsen, Anne Birgitte, Ulfeldt Hede, Mikkel, Johannsen, Niels Nørkjær, Rasmussen, Peter, Vinner, Lasse, Renaud, Gabriel, Stern, Aaron, Jensen, Theis Zetner Trolle, Scorrano, Gabriele, Schroeder, Hannes, Lysdahl, Per, Ramsøe, Abigail Daisy, Skorobogatov, Andrei, Schork, Andrew Joseph, Rosengren, Anders, Ruter, Anthony, Outram, Alan, Timoshenko, Aleksey A, Buzhilova, Alexandra, Coppa, Alfredo, Zubova, Alisa, Silva, Ana Maria, Hansen, Anders J, Gromov, Andrey, Logvin, Andrey, Gotfredsen, Anne Birgitte, Henning Nielsen, Bjarne, González-Rabanal, Borja, Lalueza-Fox, Carles, McKenzie, Catriona J, Gaunitz, Charleen, Blasco, Concepción, Liesau, Corina, Martinez-Labarga, Cristina, Pozdnyakov, Dmitri V, Cuenca-Solana, David, Lordkipanidze, David O, En’shin, Dmitri, Salazar-García, Domingo C, Price, T Douglas, Borić, Dušan, Kostyleva, Elena, Veselovskaya, Elizaveta V, Usmanova, Emma R, Cappellini, Enrico, Brinch Petersen, Erik, Kannegaard, Esben, Radina, Francesca, Eylem Yediay, Fulya, Duday, Henri, Gutiérrez-Zugasti, Igor, Merts, Ilya, Potekhina, Inna, Shevnina, Irina, Altinkaya, Isin, Guilaine, Jean, Hansen, Jesper, Aura Tortosa, Joan Emili, Zilhão, João, Vega, Jorge, Buck Pedersen, Kristoffer, Tunia, Krzysztof, Zhao, Lei, Mylnikova, Liudmila N, Larsson, Lars, Metz, Laure, Yepiskoposyan, Levon, Pedersen, Lisbeth, Sarti, Lucia, Orlando, Ludovic, Slimak, Ludovic, Klassen, Lutz, Blank, Malou, González-Morales, Manuel, and Silvestrini, Mara

Subjects
Biological Sciences, Genetics, History, Heritage and Archaeology, Human Society, Historical Studies, Anthropology, Human Genome, Humans, Agriculture, Asia, Western, Black Sea, Diploidy, Europe, Genetics, Population, Genome, Human, Genotype, History, Ancient, Human Migration, Hunting, Metagenomics, Ice Cover, General Science & Technology
Abstract

Western Eurasia witnessed several large-scale human migrations during the Holocene1-5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.

Published
2024

7. A genetic history of continuity and mobility in the Iron Age central Mediterranean

Author

Moots, Hannah M., Antonio, Margaret, Sawyer, Susanna, Spence, Jeffrey P., Oberreiter, Victoria, Weiß, Clemens L., Lucci, Michaela, Cherifi, Yahia Mehdi Seddik, La Pastina, Francesco, Genchi, Francesco, Praxmeier, Elisa, Zagorc, Brina, Cheronet, Olivia, Özdoğan, Kadir T., Demetz, Lea, Amrani, Selma, Candilio, Francesca, De Angelis, Daniela, Gasperetti, Gabriella, Fernandes, Daniel, Gao, Ziyue, Fantar, Mounir, Coppa, Alfredo, Pritchard, Jonathan K., and Pinhasi, Ron

Published
2023
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8. Fuzzing Symbolic Expressions

Author

Borzacchiello, Luca, Coppa, Emilio, and Demetrescu, Camil

Subjects
Computer Science - Software Engineering, Computer Science - Cryptography and Security
Abstract

Recent years have witnessed a wide array of results in software testing, exploring different approaches and methodologies ranging from fuzzers to symbolic engines, with a full spectrum of instances in between such as concolic execution and hybrid fuzzing. A key ingredient of many of these tools is Satisfiability Modulo Theories (SMT) solvers, which are used to reason over symbolic expressions collected during the analysis. In this paper, we investigate whether techniques borrowed from the fuzzing domain can be applied to check whether symbolic formulas are satisfiable in the context of concolic and hybrid fuzzing engines, providing a viable alternative to classic SMT solving techniques. We devise a new approximate solver, FUZZY-SAT, and show that it is both competitive with and complementary to state-of-the-art solvers such as Z3 with respect to handling queries generated by hybrid fuzzers.

Published
2021
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10. Hiding in the Particles: When Return-Oriented Programming Meets Program Obfuscation

Author

Borrello, Pietro, Coppa, Emilio, and D'Elia, Daniele Cono

Subjects
Computer Science - Cryptography and Security, Computer Science - Software Engineering, D.4.6
Abstract

Largely known for attack scenarios, code reuse techniques at a closer look reveal properties that are appealing also for program obfuscation. We explore the popular return-oriented programming paradigm under this light, transforming program functions into ROP chains that coexist seamlessly with the surrounding software stack. We show how to build chains that can withstand popular static and dynamic deobfuscation approaches, evaluating the robustness and overheads of the design over common programs. The results suggest a significant amount of computational resources would be required to carry a deobfuscation attack for secret finding and code coverage goals., Comment: Published in the proceedings of DSN'21 (51st IEEE/IFIP Int. Conf. on Dependable Systems and Networks). Code and BibTeX entry available at https://github.com/pietroborrello/raindrop

Published
2020
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11. Safety and antitumor activity of metformin plus lanreotide in patients with advanced gastro-intestinal or lung neuroendocrine tumors: the phase Ib trial MetNET2

Author

Pusceddu, Sara, Corti, Francesca, Prinzi, Natalie, Nichetti, Federico, Ljevar, Silva, Busico, Adele, Cascella, Tommaso, Leporati, Rita, Oldani, Simone, Pircher, Chiara Carlotta, Coppa, Jorgelina, Resi, Veronica, Milione, Massimo, Maccauro, Marco, Miceli, Rosalba, Tamborini, Elena, Perrone, Federica, Spreafico, Carlo, Niger, Monica, Morano, Federica, Pietrantonio, Filippo, Seregni, Ettore, Mariani, Luigi, Mazzaferro, Vincenzo, Di Liberti, Giorgia, Fucà, Giovanni, de Braud, Filippo, and Vernieri, Claudio

Published
2023
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12. Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial

Author

Corti, Francesca, Brizzi, Maria Pia, Amoroso, Vito, Giuffrida, Dario, Panzuto, Francesco, Campana, Davide, Prinzi, Natalie, Milione, Massimo, Cascella, Tommaso, Spreafico, Carlo, Randon, Giovanni, Oldani, Simone, Leporati, Rita, Scotto, Giulia, Pulice, Iolanda, Stocchetti, Benedetta Lombardi, Porcu, Luca, Coppa, Jorgelina, Di Bartolomeo, Maria, de Braud, Filippo, and Pusceddu, Sara

Published
2023
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17. WEIZZ: Automatic Grey-box Fuzzing for Structured Binary Formats

Author

Fioraldi, Andrea, D'Elia, Daniele Cono, and Coppa, Emilio

Subjects
Computer Science - Cryptography and Security
Abstract

Fuzzing technologies have evolved at a fast pace in recent years, revealing bugs in programs with ever increasing depth and speed. Applications working with complex formats are however more difficult to take on, as inputs need to meet certain format-specific characteristics to get through the initial parsing stage and reach deeper behaviors of the program. Unlike prior proposals based on manually written format specifications, in this paper we present a technique to automatically generate and mutate inputs for unknown chunk-based binary formats. We propose a technique to identify dependencies between input bytes and comparison instructions, and later use them to assign tags that characterize the processing logic of the program. Tags become the building block for structure-aware mutations involving chunks and fields of the input. We show that our techniques performs comparably to structure-aware fuzzing proposals that require human assistance. Our prototype implementation WEIZZ revealed 16 unknown bugs in widely used programs.

Published
2019
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18. Publisher Correction: Population genomics of post-glacial western Eurasia

Author

Allentoft, Morten E., Sikora, Martin, Refoyo-Martínez, Alba, Irving-Pease, Evan K., Fischer, Anders, Barrie, William, Ingason, Andrés, Stenderup, Jesper, Sjögren, Karl-Göran, Pearson, Alice, Sousa da Mota, Bárbara, Schulz Paulsson, Bettina, Halgren, Alma, Macleod, Ruairidh, Jørkov, Marie Louise Schjellerup, Demeter, Fabrice, Sørensen, Lasse, Nielsen, Poul Otto, Henriksen, Rasmus A., Vimala, Tharsika, McColl, Hugh, Margaryan, Ashot, Ilardo, Melissa, Vaughn, Andrew, Fischer Mortensen, Morten, Nielsen, Anne Birgitte, Ulfeldt Hede, Mikkel, Johannsen, Niels Nørkjær, Rasmussen, Peter, Vinner, Lasse, Renaud, Gabriel, Stern, Aaron, Jensen, Theis Zetner Trolle, Scorrano, Gabriele, Schroeder, Hannes, Lysdahl, Per, Ramsøe, Abigail Daisy, Skorobogatov, Andrei, Schork, Andrew Joseph, Rosengren, Anders, Ruter, Anthony, Outram, Alan, Timoshenko, Aleksey A., Buzhilova, Alexandra, Coppa, Alfredo, Zubova, Alisa, Silva, Ana Maria, Hansen, Anders J., Gromov, Andrey, Logvin, Andrey, Gotfredsen, Anne Birgitte, Henning Nielsen, Bjarne, González-Rabanal, Borja, Lalueza-Fox, Carles, McKenzie, Catriona J., Gaunitz, Charleen, Blasco, Concepción, Liesau, Corina, Martinez-Labarga, Cristina, Pozdnyakov, Dmitri V., Cuenca-Solana, David, Lordkipanidze, David O., En’shin, Dmitri, Salazar-García, Domingo C., Price, T. Douglas, Borić, Dušan, Kostyleva, Elena, Veselovskaya, Elizaveta V., Usmanova, Emma R., Cappellini, Enrico, Brinch Petersen, Erik, Kannegaard, Esben, Radina, Francesca, Eylem Yediay, Fulya, Duday, Henri, Gutiérrez-Zugasti, Igor, Merts, Ilya, Potekhina, Inna, Shevnina, Irina, Altinkaya, Isin, Guilaine, Jean, Hansen, Jesper, Aura Tortosa, Joan Emili, Zilhão, João, Vega, Jorge, Buck Pedersen, Kristoffer, Tunia, Krzysztof, Zhao, Lei, Mylnikova, Liudmila N., Larsson, Lars, Metz, Laure, Yepiskoposyan, Levon, Pedersen, Lisbeth, Sarti, Lucia, Orlando, Ludovic, Slimak, Ludovic, Klassen, Lutz, Blank, Malou, González-Morales, Manuel, Silvestrini, Mara, Vretemark, Maria, Nesterova, Marina S., Rykun, Marina, Rolfo, Mario Federico, Szmyt, Marzena, Przybyła, Marcin, Calattini, Mauro, Sablin, Mikhail, Dobisíková, Miluše, Meldgaard, Morten, Johansen, Morten, Berezina, Natalia, Card, Nick, Saveliev, Nikolai A., Poshekhonova, Olga, Rickards, Olga, Lozovskaya, Olga V., Gábor, Olivér, Uldum, Otto Christian, Aurino, Paola, Kosintsev, Pavel, Courtaud, Patrice, Ríos, Patricia, Mortensen, Peder, Lotz, Per, Persson, Per, Bangsgaard, Pernille, de Barros Damgaard, Peter, Vang Petersen, Peter, Martinez, Pilar Prieto, Włodarczak, Piotr, Smolyaninov, Roman V., Maring, Rikke, Menduiña, Roberto, Badalyan, Ruben, Iversen, Rune, Turin, Ruslan, Vasilyev, Sergey, Wåhlin, Sidsel, Borutskaya, Svetlana, Skochina, Svetlana, Sørensen, Søren Anker, Andersen, Søren H., Jørgensen, Thomas, Serikov, Yuri B., Molodin, Vyacheslav I., Smrcka, Vaclav, Merts, Victor, Appadurai, Vivek, Moiseyev, Vyacheslav, Magnusson, Yvonne, Kjær, Kurt H., Lynnerup, Niels, Lawson, Daniel J., Sudmant, Peter H., Rasmussen, Simon, Korneliussen, Thorfinn Sand, Durbin, Richard, Nielsen, Rasmus, Delaneau, Olivier, Werge, Thomas, Racimo, Fernando, Kristiansen, Kristian, and Willerslev, Eske

Published
2024
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19. Gridless particle technique for the Vlasov Poisson system in problems with high degree of symmetry

Author

Boella, E., Coppa, G., Angola, A. D, and Paradisi, B. Peiretti

Subjects
Physics - Plasma Physics, Physics - Computational Physics
Abstract

In the paper, gridless particle techniques are presented in order to solve problems involving electrostatic, collisionless plasmas. The method makes use of computational particles having the shape of spherical shells or of rings, and can be used to study cases in which the plasma has spherical or axial symmetry, respectively. As a computational grid is absent, the technique is particularly suitable when the plasma occupies a rapidly changing space region.

Published
2019

27. Large-scale migration into Britain during the Middle to Late Bronze Age

Author

Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David

Published
2022
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29. A Survey of Symbolic Execution Techniques

Author

Baldoni, Roberto, Coppa, Emilio, D'Elia, Daniele Cono, Demetrescu, Camil, and Finocchi, Irene

Subjects
Computer Science - Software Engineering, Computer Science - Programming Languages
Abstract

Many security and software testing applications require checking whether certain properties of a program hold for any possible usage scenario. For instance, a tool for identifying software vulnerabilities may need to rule out the existence of any backdoor to bypass a program's authentication. One approach would be to test the program using different, possibly random inputs. As the backdoor may only be hit for very specific program workloads, automated exploration of the space of possible inputs is of the essence. Symbolic execution provides an elegant solution to the problem, by systematically exploring many possible execution paths at the same time without necessarily requiring concrete inputs. Rather than taking on fully specified input values, the technique abstractly represents them as symbols, resorting to constraint solvers to construct actual instances that would cause property violations. Symbolic execution has been incubated in dozens of tools developed over the last four decades, leading to major practical breakthroughs in a number of prominent software reliability applications. The goal of this survey is to provide an overview of the main ideas, challenges, and solutions developed in the area, distilling them for a broad audience. The present survey has been accepted for publication at ACM Computing Surveys. If you are considering citing this survey, we would appreciate if you could use the following BibTeX entry: http://goo.gl/Hf5Fvc, Comment: This is the authors pre-print copy. If you are considering citing this survey, we would appreciate if you could use the following BibTeX entry: http://goo.gl/Hf5Fvc

Published
2016

30. A NOVEL OPSONIC EXTRACELLULAR CIRP INHIBITOR MOP3 ALLEVIATES GUT ISCHEMIA/REPERFUSION INJURY

Author

Hollis, Russell, Li, Jingsong, Lee, Yongchan, Jin, Hui, Zhou, Mian, Nofi, Colleen P., Sfakianos, Maria, Coppa, Gene, Aziz, Monowar, and Wang, Ping

Abstract

Introduction:Gut ischemia and reperfusion (I/R) injury promotes the release of damage-associated molecular patterns (DAMPs) such as extracellular cold-inducible RNA-binding protein (eCIRP). Gut I/R often leads to acute lung injury (ALI), a major contributor to mortality. Milk fat globule-epidermal growth factor–factor VIII–derived oligopeptide-3 (MOP3) is a novel peptide that attenuates sepsis by opsonizing eCIRP and facilitating its phagocytic clearance. We hypothesized that MOP3 reduces inflammation, mitigates gut and lung injury, and improves survival in gut I/R injury. Methods:Phagocytosis of FITC-labeled eCIRP by intestinal epithelial cells was determined by confocal microscopy, and the cell supernatant was evaluated for cytokine expression by ELISA. Adult C57BL/6 mice underwent 60 min of gut ischemia via superior mesenteric artery occlusion followed by reperfusion. Mice were treated with MOP3 or vehicle via retro-orbital injection at the time of reperfusion. At 4 h post-I/R, blood, gut, and lungs were harvested for further assay. In additional mice, 36-h survival was assessed. Plasma levels of injury and inflammatory markers were measured with colorimetry and ELISA, respectively. Tissue mRNA expression was measured with qPCR. Myeloperoxidase (MPO), TUNEL, histologic injury, and ZO-1 immunohistochemistry assessments were performed. Results:MOP3 significantly increased eCIRP phagocytosis by intestinal epithelial cells (P< 0.01) and decreased IL-6 release (P< 0.001). Gut I/R caused elevated plasma eCIRP levels. MOP3 treatment significantly reduced plasma levels of IL-1β (P< 0.01), IL-6 (P< 0.05), and lactate dehydrogenase (P< 0.05) along with a significant decrease in gut (P< 0.05) and lung (P< 0.001) injury scores as well as gut cell death (P< 0.05). Moreover, MOP3 reduced pulmonary levels of chemokines and the granulocyte activation marker MPO after gut I/R. Mechanistically, ZO-1 expression in the gut was decreased following gut I/R injury, whereas MOP3 significantly reversed the decrease in ZO-1 mRNA expression (P< 0.001). Finally, mice treated with MOP3 exhibited a significant decrease in mortality (P< 0.05). Conclusions:Treatment with MOP3 effectively mitigates organ injury induced by gut I/R. This beneficial effect is attributed to the facilitation of eCIRP clearance, directing the potential of MOP3 as an innovative therapeutic approach for this critical and often fatal condition.

Published
2025
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31. SENSING A PATTERN.

Author

COPPA, GREG

Abstract

The article in the "Horticulture" journal discusses the impact of warmer temperatures on plant growth in Rhode Island in 2024. The author notes that various plants bloomed earlier than usual, such as hydrangeas and cherry blossoms, due to the warmer soil temperatures. Additionally, the article highlights the potential consequences of mild winters, such as increased insect populations and weed growth. The author also speculates on the future horticultural possibilities in the region as temperatures continue to rise. [Extracted from the article]

Published
2025

32. Relationship between milk intrinsic quality scores and the environmental impact scores of dairy farms

Author

Lepoivre, Mathieu, Laurent, Claire, Martin, Bruno, Grollemund, Paul-Marie, Botreau, Raphaëlle, Monsallier, Françoise, Hulin, Sophie, Gerber, Pauline, Chassard, Christophe, and Coppa, Mauro

Abstract

AbstractThis study aimed to study the relationship between milk quality for cheese manufacturing and farm’s environmental impacts in grass-based mountain systems. Beforehand, the multi-criteria evaluation methodology proposed by Botreau et al. and Rey-Cadilhac et al. was adapted to a routine use. Milk quality scores were constructed by weighing traits possibly predicted by spectroscopic analyses currently available in milk labs into 4 dimensions: health, nutritional, technological and sensory. Environmental impact scores were constructed by combining 6 indicators of the CAP'2ER®software in 5 dimensions: greenhouse gas emissions, eutrophication, air acidification, consumption of space and non-renewable energies and ecosystem biodiversity. The study sample included 15 dairy farms located in the French Massif Central mountains. An analysis of variance was carried out to study the effect of system’s types on milk quality and environmental impact scores. A principal component analysis was used to study the relationship between milk quality and environmental impact dimensions scores. No correlation has been established between overall milk quality and overall environmental impact scores. High scores for the nutritional and biodiversity dimensions and low scores for the resource consumption dimension, were associated with farming practices such as a high proportion of grasslands in the usable agricultural area, low stocking rate and low productivity per cow. This demonstrates the importance of defining specific priority objectives, on a farm-by-farm basis, in order to drive changes in agricultural practices. The multi-criteria evaluation model tested here appeared sensitive, but it needs to be tested on a larger scale and in different contexts.

Published
2024
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34. Study on Coulomb explosions of ion mixtures

Author

Boella, E., Paradisi, B. Peiretti, D'Angola, A., Coppa, G., and Silva, L. O.

Subjects
Physics - Plasma Physics
Abstract

The paper presents a theoretical work on the dynamics of Coulomb explosion for spherical nanoplasmas composed by two different ion species. Particular attention has been dedicated to study the energy spectra of the ions with the larger charge-to-mass ratio. The connection between the formation of shock shells and the energy spread of the ions has been the object of a detailed analysis, showing that under particular conditions the width of the asymptotic energy spectrum tends to become very narrow, which leads to a multi-valued ion phase-space. The conditions to generate a quasi mono-energetic ion spectrum have been rigorously demonstrated and verifed by numerical simulations, using a technique that, exploiting the spherical symmetry of the problem, allows one to obtain very accurate and precise results.

Published
2015
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35. On data skewness, stragglers, and MapReduce progress indicators

Author

Coppa, Emilio and Finocchi, Irene

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Performance, Computer Science - Software Engineering
Abstract

We tackle the problem of predicting the performance of MapReduce applications, designing accurate progress indicators that keep programmers informed on the percentage of completed computation time during the execution of a job. Through extensive experiments, we show that state-of-the-art progress indicators (including the one provided by Hadoop) can be seriously harmed by data skewness, load unbalancing, and straggling tasks. This is mainly due to their implicit assumption that the running time depends linearly on the input size. We thus design a novel profile-guided progress indicator, called NearestFit, that operates without the linear hypothesis assumption and exploits a careful combination of nearest neighbor regression and statistical curve fitting techniques. Our theoretical progress model requires fine-grained profile data, that can be very difficult to manage in practice. To overcome this issue, we resort to computing accurate approximations for some of the quantities used in our model through space- and time-efficient data streaming algorithms. We implemented NearestFit on top of Hadoop 2.6.0. An extensive empirical assessment over the Amazon EC2 platform on a variety of real-world benchmarks shows that NearestFit is practical w.r.t. space and time overheads and that its accuracy is generally very good, even in scenarios where competitors incur non-negligible errors and wide prediction fluctuations. Overall, NearestFit significantly improves the current state-of-art on progress analysis for MapReduce.

Published
2015

41. The zCOSMOS Redshift Survey: evolution of the light in bulges and discs since z~0.8

Author

Tasca, L. A. M., Tresse, L., Fevre, O. Le, Ilbert, O., Lilly, S. J., Zamorani, G., Lopez-Sanjuan, C., Ho, L. C., Bardelli, S., Cattaneo, A., Cucciati, O., Farrah, D., Iovino, A., Koekemoer, A. M., Liu, C. T., Massey, R., Renzini, A., Taniguchi, Y., Welikala, N., Zucca, E., Carollo, C. M., Contini, T., Kneib, J. P., Mainieri, V., Scodeggio, M., Bolzonella, M., Bongiorno, A., Caputi, K., de la Torre, S., Franzetti, P., Garilli, B., Guzzo, L., Kampczyk, P., Knobel, C., Kovavc, K., Lamareille, F., Borgne, J. -F. Le, Brun, V. Le, Maier, C., Mignoli, M., Pello, R., Peng, Y., Montero, E. Perez, Rich, R. M., Tanaka, M., Vergani, D., Bordoloi, R., Cappi, A., Cimatti, A., Coppa, G., McCracken, H. J., Moresco, M., Pozzetti, L., Sanders, D., and Sheth, K.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We studied the chronology of galactic bulge and disc formation by analysing the relative contributions of these components to the B-band rest-frame luminosity density at different epochs. We present the first estimate of the evolution of the fraction of rest-frame B-band light in galactic bulges and discs since redshift z~0.8. We performed a bulge-to-disc decomposition of HST/ACS images of 3266 galaxies in the zCOSMOS-bright survey with spectroscopic redshifts in the range 0.7 < z < 0.9. We find that the fraction of B-band light in bulges and discs is $(26 \pm 4)%$ and $(74 \pm 4)%$, respectively. When compared with rest-frame B-band measurements of galaxies in the local Universe in the same mass range ($10^{9} M_{\odot}\lessapprox M \lessapprox 10^{11.5} M_{\odot}$), we find that the B-band light in discs decreases by ~30% from z~0.7-0.9 to z~0, while the light from the bulge increases by ~30% over the same period of time. We interpret this evolution as the consequence of star formation and mass assembly processes, as well as morphological transformation, which gradually shift stars formed at half the age of the Universe from star-forming late-type/irregular galaxies toearlier types and ultimately into spheroids., Comment: Letter to the Editor, 4 pages, 2 figures, accepted for publication in Astronomy and Astrophysics

Published
2014
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42. A genetic history of the pre-contact Caribbean

Author

Fernandes, Daniel M., Sirak, Kendra A., Ringbauer, Harald, Sedig, Jakob, Rohland, Nadin, Cheronet, Olivia, Mah, Matthew, Mallick, Swapan, Olalde, Iñigo, Culleton, Brendan J., Adamski, Nicole, Bernardos, Rebecca, Bravo, Guillermo, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Demetz, Lea, Carlson, Kellie Sara Duffett, Eccles, Laurie, Freilich, Suzanne, George, Richard J., Lawson, Ann Marie, Mandl, Kirsten, Marzaioli, Fabio, McCool, Weston C., Oppenheimer, Jonas, Özdogan, Kadir T., Schattke, Constanze, Schmidt, Ryan, Stewardson, Kristin, Terrasi, Filippo, Zalzala, Fatma, Antúnez, Carlos Arredondo, Canosa, Ercilio Vento, Colten, Roger, Cucina, Andrea, Genchi, Francesco, Kraan, Claudia, La Pastina, Francesco, Lucci, Michaela, Maggiolo, Marcio Veloz, Marcheco-Teruel, Beatriz, Maria, Clenis Tavarez, Martínez, Christian, París, Ingeborg, Pateman, Michael, Simms, Tanya M., Sivoli, Carlos Garcia, Vilar, Miguel, Kennett, Douglas J., Keegan, William F., Coppa, Alfredo, Lipson, Mark, Pinhasi, Ron, and Reich, David

Published
2021
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44. The spread of steppe and Iranian-related ancestry in the islands of the western Mediterranean

Author

Fernandes, Daniel M., Mittnik, Alissa, Olalde, Iñigo, Lazaridis, Iosif, Cheronet, Olivia, Rohland, Nadin, Mallick, Swapan, Bernardos, Rebecca, Broomandkhoshbacht, Nasreen, Carlsson, Jens, Culleton, Brendan J., Ferry, Matthew, Gamarra, Beatriz, Lari, Martina, Mah, Matthew, Michel, Megan, Modi, Alessandra, Novak, Mario, Oppenheimer, Jonas, Sirak, Kendra A., Stewardson, Kristin, Mandl, Kirsten, Schattke, Constanze, Özdoğan, Kadir T., Lucci, Michaela, Gasperetti, Gabriella, Candilio, Francesca, Salis, Gianfranca, Vai, Stefania, Camarós, Edgard, Calò, Carla, Catalano, Giulio, Cueto, Marián, Forgia, Vincenza, Lozano, Marina, Marini, Elisabetta, Micheletti, Margherita, Miccichè, Roberto M., Palombo, Maria R., Ramis, Damià, Schimmenti, Vittoria, Sureda, Pau, Teira, Luís, Teschler-Nicola, Maria, Kennett, Douglas J., Lalueza-Fox, Carles, Patterson, Nick, Sineo, Luca, Coppa, Alfredo, Caramelli, David, Pinhasi, Ron, and Reich, David

Published
2020
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46. The dependence of Galactic outflows on the properties and orientation of zCOSMOS galaxies at z ~ 1

Author

Bordoloi, R., Lilly, S. J., Hardmeier, E., Contini, T., Kneib, J. -P., Fevre, O. Le, Mainieri, V., Renzini, A., Scodeggio, M., Zamorani, G., Bardelli, S., Bolzonella, M., Bongiorno, A., Caputi, K., Carollo, C. M., Cucciati, O., de la Torre, S., de Ravel, L., Garilli, B., Iovino, A., Kampczyk, P., Kovac, K., Knobel, C., Lamareille, F., Borgne, J. -F. Le, Brun, V. Le, Maier, C., Mignoli, M., Oesch, P., Pello, R., Peng, Y., Montero, E. Perez, Presotto, V., Silverman, J., Tanaka, M., Tasca, L., Tresse, L., Vergani, D., Zucca, E., Cappi, A., Cimatti, A., Coppa, G., Franzetti, P., Koekemoer, A., Moresco, M., Nair, P., and Pozzetti, L.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present an analysis of cool outflowing gas around galaxies, traced by MgII absorption lines in the co-added spectra of a sample of 486 zCOSMOS galaxies at 1 < z < 1.5. These galaxies span a range of stellar masses (9.45< log[M*/Msun]<10.7) and star formation rates (0.14 < log [SFR/Msun/yr] < 2.35). We identify the cool outflowing component in the MgII absorption and find that the equivalent width of the outflowing component increases with stellar mass. The outflow equivalent width also increases steadily with the increasing star formation rate of the galaxies. At similar stellar masses the blue galaxies exhibit a significantly higher outflow equivalent width as compared to red galaxies. The outflow equivalent width shows strong effect with star formation surface density ({\Sigma}SFR) of the sample. For the disk galaxies, the outflow equivalent width is higher for the face-on systems as compared to the edge-on ones, indicating that for the disk galaxies, the outflowing gas is primarily bipolar in geometry. Galaxies typically exhibit outflow velocities ranging from -200 km/s to -300 km/s and on average the face-on galaxies exhibit higher outflow velocity as compared to the edge-on ones. Galaxies with irregular morphologies exhibit outflow equivalent width as well as outflow velocities comparable to face on disk galaxies. These galaxies exhibit minimum mass outflow rates > 5-7 Msun/yr and a mass loading factor ({\eta} = dMout/dt /SFR) comparable to the star formation rates of the galaxies., Comment: 12 pages, 14 figures, ApJ submitted

Published
2013
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47. Multithreaded Input-Sensitive Profiling

Author

Coppa, Emilio, Demetrescu, Camil, Finocchi, Irene, and Marotta, Romolo

Subjects
Computer Science - Performance, Computer Science - Programming Languages, 68N30, C.4, D.2.8
Abstract

Input-sensitive profiling is a recent performance analysis technique that makes it possible to estimate the empirical cost function of individual routines of a program, helping developers understand how performance scales to larger inputs and pinpoint asymptotic bottlenecks in the code. A current limitation of input-sensitive profilers is that they specifically target sequential computations, ignoring any communication between threads. In this paper we show how to overcome this limitation, extending the range of applicability of the original approach to multithreaded applications and to applications that operate on I/O streams. We develop new metrics for automatically estimating the size of the input given to each routine activation, addressing input produced by non-deterministic memory stores performed by other threads as well as by the OS kernel (e.g., in response to I/O or network operations). We provide real case studies, showing that our extension allows it to characterize the behavior of complex applications more precisely than previous approaches. An extensive experimental investigation on a variety of benchmark suites (including the SPEC OMP2012 and the PARSEC benchmarks) shows that our Valgrind-based input-sensitive profiler incurs an overhead comparable to other prominent heavyweight analysis tools, while collecting significantly more performance points from each profiling session and correctly characterizing both thread-induced and external input.

Published
2013

48. Investigating the relationship between AGN activity and stellar mass in zCOSMOS galaxies at 0<z<1 using emission line diagnostic diagrams

Author

Vitale, M., Mignoli, M., Cimatti, A., Lilly, S. J., Carollo, C. M., Contini, T., Kneib, J. -P., Fevre, O. Le, Mainieri, V., Renzini, A., Scodeggio, M., Zamorani, G., Bardelli, S., Barnes, L., Bolzonella, M., Bongiorno, A., Bordoloi, R., Bschorr, T. J., Cappi, A., Caputi, K., Coppa, G., Cucciati, O., de la Torre, S., de Ravel, L., Franzetti, P., Garilli, B., Iovino, A., Kampczyk, P., Knobel, C., Koekemoer, A. M., Kovac, K., Lamareille, F., Borgne, J. -F. Le, Brun, V. Le, Lopez-Sanjuan, C., Maier, C., McCracken, H. J., Moresco, M., Nair, P., Oesch, P. A., Pello, R., Peng, Y., Montero, E. Perez, Pozzetti, L., Presotto, V., Silverman, J., Tanaka, M., Tasca, L., Tresse, L., Vergani, D., Welikala, N., and Zucca, E.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We investigate the link between AGN activity, star-formation and stellar mass of the host galaxy at 010.2 threshold. Moreover, the stellar populations of AGN hosts are found to be older with respect to star-forming and composites galaxies. This could be due to the the tendency of AGN to reside in massive hosts. The dependence of the AGN classification on the stellar mass is in agreement with what has been already found in previous studies. It is consistent with, together with the evidence of older stellar populations inhabiting the AGN-like galaxies, the downsizing scenario. In particular, our evidence points to an evolutionary scenario where the AGN-feedback is capable of quenching the star formation in the most massive galaxies. Therefore, the AGN-feedback is the best candidate for initiating the passive evolutionary phase of galaxies., Comment: Accepted for publication in A&A

Published
2013
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49. The Impact of Partnership Status on Diabetes Control and Self-Management Behaviors

Author

Haines, Lindsay, Coppa, Natalie, Harris, Yael, Wisnivesky, Juan P., and Lin, Jenny J.

Abstract

According to the Centers for Disease Control and Prevention, diabetes affects 29.1 million people in the United States. Marriage has been suggested to have a protective effect on overall health outcomes, but few studies have evaluated the role of partnership status on patients with type 2 diabetes. This study aimed to assess this role of partnership status on diabetes control and self-management behaviors. Patients with type 2 diabetes taking at least one oral hypoglycemic agent were assessed over a 3-month period to measure hemoglobin A1c (HbA1c) changes and adherence to medication, exercise, diet, and glucose monitoring. Partnered participants were more likely to adhere to their medications, but there was no significant difference in HbA1c changes over 3 months or exercise, diet, or glucose monitoring adherence. This study suggests that being partnered improves medication adherence; further analysis with a larger population is required to fully assess the role of partner support for patients with type 2 diabetes.

Published
2018
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