3,263 results on '"Coppola, G"'
Search Results
2. The effect of orthodontic treatment on smile attractiveness: a systematic review
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Coppola, G., Christopoulou, I., Gkantidis, N., Verna, C., Pandis, N., and Kanavakis, G.
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- 2023
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3. High efficiency particulate air filters and heat & moisture exchanger filters increase positive end-expiratory pressure in helmet continuous positive airway pressure: A bench-top study
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Rezoagli, E., Coppola, G., Dezza, L., Galesi, A., Gallo, G.P., Fumagalli, R., Bellani, G., Foti, G., and Lucchini, A.
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- 2024
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4. Batch and fixed bed adsorption of methylene blue onto foamed metakaolin-based geopolymer: A preliminary investigation
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Candamano, S., Coppola, G., Mazza, A., Caicho Caranqui, J.I., Bhattacharyya, S., Chakraborty, S., Alexis, F., and Algieri, C.
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- 2023
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5. Interfacing scalable photonic platforms: solid-state based multi-photon interference in a reconfigurable glass chip
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Antón, C., Loredo, J. C., Coppola, G., Ollivier, H., Viggianiello, N., Harouri, A., Somaschi, N., Crespi, A., Sagnes, I., Lemaître, A., Lanco, L., Osellame, R., Sciarrino, F., and Senellart, P.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Scaling-up optical quantum technologies requires to combine highly efficient multi-photon sources and integrated waveguide components. Here, we interface these scalable platforms: a quantum dot based multi-photon source and a reconfigurable photonic chip on glass are combined to demonstrate high-rate three-photon interference. The temporal train of single-photons obtained from a quantum emitter is actively demultiplexed to generate a 3.8 kHz three-photon source, which is then sent to the input of a tuneable tritter circuit, demonstrating the on-chip quantum interference of three indistinguishable single-photons. Pseudo number-resolving photon detection characterising the output distribution shows that this first combination of scalable sources and reconfigurable photonic circuits compares favourably in performance with respect to previous implementations. A detailed loss-budget shows that merging solid-state based multi-photon sources and reconfigurable photonic chips could allow ten-photon experiments on chip at ${\sim}40$ Hz rate in a foreseeable future., Comment: 7 pages, 4 figures, 2 tables
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- 2019
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6. Numerical treatment of the energy equation in compressible flows simulations
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De Michele, C. and Coppola, G.
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- 2023
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7. Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort
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Heuer, Hilary W, Wang, P, Rascovsky, K, Wolf, A, Appleby, B, Bove, J, Bordelon, Y, Brannelly, P, Brushaber, DE, Caso, C, Coppola, G, Dickerson, B, Dickinson, S, Domoto‐Reilly, K, Faber, K, Ferrall, J, Fields, J, Fishman, A, Fong, J, Foroud, T, Forsberg, LK, Gearhart, D, Ghazanfari, B, Ghoshal, N, Goldman, J, Graff‐Radford, J, Graff‐Radford, N, Grant, I, Grossman, M, Haley, D, Hsiung, G‐Y, Huey, E, Irwin, D, Jones, D, Kantarci, K, Karydas, A, Kaufer, D, Kerwin, D, Knopman, D, Kornak, J, Kramer, JH, Kraft, R, Kremers, WK, Kukull, W, Litvan, I, Ljubenkov, P, Mackenzie, IR, Maldonado, M, Manoochehri, M, McGinnis, S, McKinley, E, Mendez, MF, Miller, BL, Onyike, C, Pantelyat, A, Pearlman, R, Petrucelli, L, Potter, M, Rademakers, R, Ramos, EM, Rankin, KP, Roberson, ED, Rogalski, E, Sengdy, P, Shaw, L, Syrjanen, J, Tartaglia, MC, Tatton, N, Taylor, J, Toga, A, Trojanowski, J, Weintraub, S, Wong, B, Wszolek, Z, Boeve, BF, Rosen, HJ, Boxer, AL, and consortia, on behalf of the ARTFL and LEFFTDS
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Aging ,Acquired Cognitive Impairment ,Alzheimer's Disease Related Dementias (ADRD) ,Frontotemporal Dementia (FTD) ,Behavioral and Social Science ,Genetics ,Clinical Research ,Dementia ,Rare Diseases ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Neurological ,Age Factors ,Aged ,Brain ,C9orf72 Protein ,Female ,Frontotemporal Dementia ,Genetic Predisposition to Disease ,Humans ,Male ,Middle Aged ,Mutation ,Neuropsychological Tests ,North America ,Progranulins ,tau Proteins ,bvFTD ,C9orf72 ,clinical trials ,frontotemporal dementia ,genetics ,GRN ,MAPT ,ARTFL and LEFFTDS consortia ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionBehavioral variant frontotemporal dementia (bvFTD) may present sporadically or due to an autosomal dominant mutation. Characterization of both forms will improve understanding of the generalizability of assessments and treatments.MethodsA total of 135 sporadic (s-bvFTD; mean age 63.3 years; 34% female) and 99 familial (f-bvFTD; mean age 59.9; 48% female) bvFTD participants were identified. f-bvFTD cases included 43 with known or presumed chromosome 9 open reading frame 72 (C9orf72) gene expansions, 28 with known or presumed microtubule-associated protein tau (MAPT) mutations, 14 with known progranulin (GRN) mutations, and 14 with a strong family history of FTD but no identified mutation.ResultsParticipants with f-bvFTD were younger and had earlier age at onset. s-bvFTD had higher total Neuropsychiatric Inventory Questionnaire (NPI-Q) scores due to more frequent endorsement of depression and irritability.Discussionf-bvFTD and s-bvFTD cases are clinically similar, suggesting the generalizability of novel biomarkers, therapies, and clinical tools developed in either form to the other.
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- 2020
8. Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration
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Casaletto, KB, Staffaroni, AM, Wolf, A, Appleby, B, Brushaber, D, Coppola, G, Dickerson, B, Domoto‐Reilly, K, Elahi, FM, Fields, J, Fong, JC, Forsberg, L, Ghoshal, N, Graff‐Radford, N, Grossman, M, Heuer, HW, Hsiung, G‐Y, Huey, ED, Irwin, D, Kantarci, K, Kaufer, D, Kerwin, D, Knopman, D, Kornak, J, Kramer, JH, Litvan, I, Mackenzie, IR, Mendez, M, Miller, B, Rademakers, R, Ramos, EM, Rascovsky, K, Roberson, ED, Syrjanen, JA, Tartaglia, MC, Weintraub, S, Boeve, B, Boxer, AL, Rosen, H, Yaffe, K, and Study, the ARTFL LEFFTDS
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Alzheimer's Disease Related Dementias (ADRD) ,Alzheimer's Disease ,Biomedical Imaging ,Neurodegenerative ,Neurosciences ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Behavioral and Social Science ,Rare Diseases ,Dementia ,Acquired Cognitive Impairment ,Frontotemporal Dementia (FTD) ,Brain Disorders ,Neurological ,Aged ,Atrophy ,Cognition ,Exercise ,Female ,Frontotemporal Lobar Degeneration ,Humans ,Leisure Activities ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neuropsychological Tests ,cognitive activity ,cognitive reserve ,exercise ,frontotemporal dementia ,physical activity ,ARTFL/LEFFTDS Study ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionLeisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD).MethodsA total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline, and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging (MRI) scans.ResultsGreater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates.DiscussionActive lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.
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- 2020
9. Free-space graphene/silicon photodetectors operating at 2 micron
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Casalino, M., Russo, R., Russo, C., Ciajolo, A., Di Gennaro, E., Iodice, M., and Coppola, G.
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Physics - Applied Physics ,Physics - Optics - Abstract
This paper presents the design, the fabrication and the characterization of Schottky graphene/silicon photodetectors, operating at both 2 micron and room temperature. The graphene/silicon junction has been carefully: characterized device shows a non ideal behaviour with the increasing temperature and the interfacial trap density has been measured as 1.1x10^14 eV^-1cm^-2. Photodetectors are characterized by an internal (external) responsivity of 10.3 mA/W (0.16 mA/W) in an excellent agreement with the theory. Our devices pave the way for developing hybrid graphene-Si free-space illuminated PDs operating at 2 micron, for free-space optical communications, optical coherence tomography and light-radars., Comment: 11 pages, 8 figures
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- 2017
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10. Overcomplete quantum tomography of a path-entangled two-photon state
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De Santis, L., Coppola, G., Antón, C., Somaschi, N., Gómez, C., Lemaître, A., Sagnes, I., Lanco, L., Loredo, J. C., Krebs, O., and Senellart, P.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Path-entangled N-photon states can be obtained through the coalescence of indistinguishable photons inside linear networks. They are key resources for quantum enhanced metrology, quantum imaging, as well as quantum computation based on quantum walks. However, the quantum tomography of path-entangled indistinguishable photons is still in its infancy as it requires multiple phase estimations increasing rapidly with N. Here, we propose and implement a method to measure the quantum tomography of path-entangled two-photon states. A two-photon state is generated through the Hong-Ou-Mandel interference of highly indistinguishable single photons emitted by a semiconductor quantum dot-cavity device. To access both the populations and the coherences of the path-encoded density matrix, we introduce an ancilla spatial mode and perform photon correlations as a function of a single phase in a split Mach-Zehnder interferometer. We discuss the accuracy of standard quantum tomography techniques and show that an overcomplete data set can reveal spatial coherences that could be otherwise hidden due to limited or noisy statistics. Finally, we extend our analysis to extract the truly indistinguishable part of the density matrix, which allows us to identify the main origin for the imperfect fidelity to the maximally entangled state., Comment: 7 pages, 5 figures
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- 2017
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11. Vertically-Illuminated, Resonant-Cavity-Enhanced, Graphene-Silicon Schottky Photodetectors
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Casalino, M., Sassi, U., Goykhman, I., Eiden, A., Lidorikis, E., Milana, S., De Fazio, D., Tomarchio, F., Iodice, M., Coppola, G., and Ferrari, A. C.
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Physics - Applied Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
We report vertically-illuminated, resonant cavity enhanced, graphene-Si Schottky photodetectors (PDs) operating at 1550nm. These exploit internal photoemission at the graphene-Si interface. To obtain spectral selectivity and enhance responsivity, the PDs are integrated with an optical cavity, resulting in multiple reflections at resonance, and enhanced absorption in graphene. Our devices have wavelength-dependent photoresponse with external (internal) responsivity~20mA/W (0.25A/W). The spectral-selectivity may be further tuned by varying the cavity resonant wavelength. Our devices pave the way for developing high responsivity hybrid graphene-Si free-space illuminated PDs for free-space optical communications, coherence optical tomography and light-radars
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- 2017
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12. Dopamine receptor D4 (DRD 4 ) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia
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Butler, PM, Chiong, W, Perry, DC, Miller, ZA, Gennatas, ED, Brown, JA, Pasquini, L, Karydas, A, Dokuru, D, Coppola, G, Sturm, VE, Boxer, AL, Gorno-Tempini, ML, Rosen, HJ, Kramer, JH, Miller, BL, and Seeley, WW
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Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Neurodegenerative ,Basic Behavioral and Social Science ,Acquired Cognitive Impairment ,Aging ,Dementia ,Alzheimer's Disease ,Frontotemporal Dementia (FTD) ,Brain Disorders ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Rare Diseases ,Neurosciences ,Genetics ,Behavioral and Social Science ,Alzheimer's Disease Related Dementias (ADRD) ,2.1 Biological and endogenous factors ,Neurological ,Aged ,Alzheimer Disease ,Atrophy ,Brain ,Female ,Frontotemporal Dementia ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neuropsychological Tests ,Polymorphism ,Genetic ,Receptors ,Dopamine D4 ,Syndrome ,Frontotemporal dementia ,DRD4 ,Apathy ,Insula ,Anterior cingulate cortex ,Salience network ,DRD(4) ,Biological psychology ,Clinical and health psychology - Abstract
ObjectiveWe aimed to understand the impact of dopamine receptor D4 (DRD4) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRD4dampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Given that DRD4 is concentrated in anterior regions of the limbic and cortical forebrain we anticipated genotype effects in patients with a more rostral pattern of neurodegeneration.Methods337 subjects, including healthy controls, patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) underwent genotyping, structural MRI, and cognitive/behavioral testing. We conducted whole-brain voxel-based morphometry to examine the relationship between DRD4 genotypes and brain atrophy patterns within and across groups. General linear modeling was used to evaluate relationships between genotype and cognitive/behavioral measures.ResultsDRD4 dampened-variants predicted gray matter atrophy in disease-specific regions of FTD in anterior cingulate, ventromedial prefrontal, orbitofrontal and insular cortices on the right greater than the left. Genotype predicted greater apathy and repetitive motor disturbance in patients with FTD. These results covaried with frontoinsular cortical atrophy. Peak atrophy patterned along regions of neuroanatomic vulnerability in FTD-spectrum disorders. In AD subjects and controls, genotype did not impact gray matter intensity.ConclusionsWe conclude that DRD4 polymorphisms with reduced functional potency exacerbate neuronal injury in sites of higher receptor density, which intersect with syndrome-specific regions undergoing neurodegeneration in FTD.
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- 2019
13. Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.
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Butler, PM, Chiong, W, Perry, DC, Miller, ZA, Gennatas, ED, Brown, JA, Pasquini, L, Karydas, A, Dokuru, D, Coppola, G, Sturm, VE, Boxer, AL, Gorno-Tempini, ML, Rosen, HJ, Kramer, JH, Miller, BL, and Seeley, WW
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Brain ,Humans ,Alzheimer Disease ,Atrophy ,Syndrome ,Magnetic Resonance Imaging ,Neuropsychological Tests ,Polymorphism ,Genetic ,Aged ,Middle Aged ,Female ,Male ,Receptors ,Dopamine D4 ,Frontotemporal Dementia ,Anterior cingulate cortex ,Apathy ,DRD(4) ,Frontotemporal dementia ,Insula ,Salience network ,DRD4 ,Neurosciences ,Dementia ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aging ,Frontotemporal Dementia (FTD) ,Brain Disorders ,Acquired Cognitive Impairment ,Rare Diseases ,Clinical Research ,Alzheimer's Disease ,Genetics ,2.1 Biological and endogenous factors ,Neurological - Abstract
ObjectiveWe aimed to understand the impact of dopamine receptor D4 (DRD4) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRD4dampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Given that DRD4 is concentrated in anterior regions of the limbic and cortical forebrain we anticipated genotype effects in patients with a more rostral pattern of neurodegeneration.Methods337 subjects, including healthy controls, patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) underwent genotyping, structural MRI, and cognitive/behavioral testing. We conducted whole-brain voxel-based morphometry to examine the relationship between DRD4 genotypes and brain atrophy patterns within and across groups. General linear modeling was used to evaluate relationships between genotype and cognitive/behavioral measures.ResultsDRD4 dampened-variants predicted gray matter atrophy in disease-specific regions of FTD in anterior cingulate, ventromedial prefrontal, orbitofrontal and insular cortices on the right greater than the left. Genotype predicted greater apathy and repetitive motor disturbance in patients with FTD. These results covaried with frontoinsular cortical atrophy. Peak atrophy patterned along regions of neuroanatomic vulnerability in FTD-spectrum disorders. In AD subjects and controls, genotype did not impact gray matter intensity.ConclusionsWe conclude that DRD4 polymorphisms with reduced functional potency exacerbate neuronal injury in sites of higher receptor density, which intersect with syndrome-specific regions undergoing neurodegeneration in FTD.
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- 2019
14. CREB controls cortical circuit plasticity and functional recovery after stroke.
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Caracciolo, L, Marosi, M, Mazzitelli, J, Latifi, S, Sano, Y, Galvan, L, Kawaguchi, R, Holley, S, Levine, MS, Coppola, G, Portera-Cailliau, C, Silva, AJ, and Carmichael, ST
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Motor Cortex ,Motor Neurons ,Animals ,Mice ,Inbred C57BL ,Brain Mapping ,Patch-Clamp Techniques ,Gene Expression Profiling ,Recovery of Function ,Neuronal Plasticity ,Male ,Cyclic AMP Response Element-Binding Protein ,Stroke - Abstract
Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after stroke, while blocking CREB signaling prevents stroke recovery. Silencing CREB-transfected neurons in the peri-infarct region with the hM4Di-DREADD blocks motor recovery. Reversing this inhibition allows recovery to continue, demonstrating that by manipulating the activity of CREB-transfected neurons it is possible to turn off and on stroke recovery. CREB transfection enhances remapping of injured somatosensory and motor circuits, and induces the formation of new connections within these circuits. CREB is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits.
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- 2018
15. A solid-state single-photon filter
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de Santis, L., Antón, C., Reznychenko, B., Somaschi, N., Coppola, G., Senellart, J., Gómez, C., Lemaître, A., Sagnes, I., White, A. G., Lanco, L., Auffeves, A., and Senellart, P.
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Quantum Physics - Abstract
A strong limitation of linear optical quantum computing is the probabilistic operation of two-quantum bit gates based on the coalescence of indistinguishable photons. A route to deterministic operation is to exploit the single-photon nonlinearity of an atomic transition. Through engineering of the atom-photon interaction, phase shifters, photon filters and photon- photon gates have been demonstrated with natural atoms. Proofs of concept have been reported with semiconductor quantum dots, yet limited by inefficient atom-photon interfaces and dephasing. Here we report on a highly efficient single-photon filter based on a large optical non-linearity at the single photon level, in a near-optimal quantum-dot cavity interface. When probed with coherent light wavepackets, the device shows a record nonlinearity threshold around $0.3 \pm 0.1$ incident photons. We demonstrate that directly reflected pulses consist of 80% single-photon Fock state and that the two- and three-photon components are strongly suppressed compared to the single-photon one.
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- 2016
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16. The Carina Project. X. On the kinematics of old and intermediate-age stellar populations
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Fabrizio, M., Bono, G., Nonino, M., Lokas, E. L., Ferraro, I., Iannicola, G., Buonanno, R., Cassisi, S., Coppola, G., Dall'Ora, M., Gilmozzi, R., Marconi, M., Monelli, M., Romaniello, M., Stetson, P. B., Thévenin, F., and Walker, A. R.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present new radial velocity (RV) measurements of old (horizontal branch) and intermediate-age (red clump) stellar tracers in the Carina dwarf spheroidal. They are based on more than 2,200 low-resolution spectra collected with VIMOS at VLT. The targets are faint (20
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- 2016
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17. The Cepheids of NGC1866: A Precise Benchmark for the Extragalactic Distance Scale and Stellar Evolution from Modern UBVI Photometry
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Musella, I., Marconi, M., Stetson, P. B., Raimondo, G., Brocato, E., Molinaro, R., Ripepi, V., Carini, R., Coppola, G., Walker, A. R., and Welch, D. L.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the analysis of multiband time-series data for a sample of 24 Cepheids in the field of the Large Magellanic Cloud cluster NGC1866. Very accurate BVI VLT photometry is combined with archival UBVI data, covering a large temporal window, to obtain precise mean magnitudes and periods with typical errors of 1-2% and of 1 ppm, respectively. These results represent the first accurate and homogeneous dataset for a substantial sample of Cepheid variables belonging to a cluster and hence sharing common distance, age and original chemical composition. Comparisons of the resulting multiband Period-Luminosity and Wesenheit relations to both empirical and theoretical results for the Large Magellanic Cloud are presented and discussed to derive the distance of the cluster and to constrain the mass-luminosity relation of the Cepheids. The adopted theoretical scenario is also tested by comparison with independent calibrations of the Cepheid Wesenheit zero point based on trigonometric parallaxes and Baade-Wesselink techniques. Our analysis suggests that a mild overshooting and/or a moderate mass loss can affect intermediate-mass stellar evolution in this cluster and gives a distance modulus of 18.50 +- 0.01 mag. The obtained V,I color-magnitude diagram is also analysed and compared with both synthetic models and theoretical isochrones for a range of ages and metallicities and for different efficiencies of core overshooting. As a result, we find that the age of NGC1866 is about 140 Myr, assuming Z = 0.008 and the mild efficiency of overshooting suggested by the comparison with the pulsation models., Comment: 13 pages, 10 figures, accepted in MNRAS (2016 January 14)
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- 2016
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18. Scalable performance in solid-state single-photon sources
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Loredo, J. C., Zakaria, N. A., Somaschi, N., Anton, C., De Santis, L., Giesz, V., Grange, T., Broome, M. A., Gazzano, O., Coppola, G., Sagnes, I., Lemaitre, A., Auffeves, A., Senellart, P., Almeida, M. P., and White, A. G.
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Quantum Physics - Abstract
The desiderata for an ideal photon source are high brightness, high single-photon purity, and high indistinguishability. Defining brightness at the first collection lens, these properties have been simultaneously demonstrated with solid-state sources, however absolute source efficiencies remain close to the 1% level, and indistinguishability only demonstrated for photons emitted consecutively on the few nanosecond scale. Here we employ deterministic quantum dot-micropillar devices to demonstrate solid-state single-photon sources with scalable performance. In one device, an absolute brightness at the output of a single-mode fibre of 14% and purities of 97.1-99.0% are demonstrated. When non-resontantly excited, it emits a long stream of photons that exhibit indistinguishability up to 70%---above the classical limit of 50%---even after 33 consecutively emitted photons, a 400 ns separation between them. Resonant excitation in other devices results in near-optimal indistinguishability values: 96% at short timescales, remaining at 88% in timescales as large as 463 ns, after 39 emitted photons. The performance attained by our devices brings solid-state sources into a regime suitable for scalable implementations., Comment: 11 pages, 8 figures
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- 2016
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19. The Carina Project IX: on Hydrogen and helium burning variables
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Coppola, G., Marconi, M., Stetson, P. B., Bono, G., Braga, V. F., Ripepi, V., Dall'Ora, M., Musella, I., Buonanno, R., Fabrizio, M., Ferraro, I., Fiorentino, G., Iannicola, G., Monelli, M., Nonino, M., Thévenin, F., and Walker, A. R.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present new multi-band (UBVI) time-series data of helium burning variables in the Carina dwarf spheroidal galaxy. The current sample includes 92 RR Lyrae-six of them are new identifications-and 20 Anomalous Cepheids, one of which is new identification. The analysis of the Bailey diagram shows that the luminosity amplitude of the first overtone component in double-mode variables is located along the long-period tail of regular first overtone variables, while the fundamental component is located along the short-period tale of regular fundamental variables. This evidence further supports the transitional nature of these objects. Moreover, the distribution of Carina double-mode variables in the Petersen diagram (P_1/P_0 vs P_0) is similar to metal-poor globulars (M15, M68), to the dwarf spheroidal Draco and to the Galactic Halo. This suggests that the Carina old stellar population is metal-poor and affected by a small spread in metallicity. We use trigonometric parallaxes for five field RR Lyrae stars to provide an independent estimate of the Carina distance using the observed reddening free Period--Wesenheit [PW, (BV)] relation. Theory and observations indicate that this diagnostic is independent of metallicity. We found a true distance modulus of \mu=20.01\pm0.02 (standard error of the mean) \pm0.05 (standard deviation) mag. We also provided independent estimates of the Carina true distance modulus using four predicted PW relations (BV, BI, VI, BVI) and we found: \mu=(20.08\pm0.007\pm0.07) mag, \mu=(20.06\pm0.006\pm0.06) mag, \mu=(20.07\pm0.008\pm0.08) mag and \mu=(20.06\pm0.006\pm0.06) mag. Finally, we identified more than 100 new SX Phoenicis stars that together with those already known in the literature (340) make Carina a fundamental laboratory to constrain the evolutionary and pulsation properties of these transitional variables., Comment: 44 pages, 13 tables, 13 figures, Accepted for publication in ApJ
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- 2015
20. The Carina Project. VIII. The {\alpha}-element abundances
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Fabrizio, M., Nonino, M., Bono, G., Primas, F., Thévenin, F., Stetson, P. B., Cassisi, S., Buonanno, R., Coppola, G., da Silva, R. O., Dall'Ora, M., Ferraro, I., Genovali, K., Gilmozzi, R., Iannicola, G., Marconi, M., Monelli, M., Romaniello, M., and Walker, A. R.
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Astrophysics - Astrophysics of Galaxies - Abstract
We have performed a new abundance analysis of Carina Red Giant (RG) stars from spectroscopic data collected with UVES (high resolution) and FLAMES/GIRAFFE (high and medium resolution) at ESO/VLT. The former sample includes 44 RGs, while the latter consists of 65 (high) and ~800 (medium resolution) RGs, covering a significant fraction of the galaxy's RG branch (RGB), and red clump stars. To improve the abundance analysis at the faint magnitude limit, the FLAMES/GIRAFFE data were divided into ten surface gravity and effective temperature bins. The spectra of the stars belonging to the same gravity/temperature bin were stacked. This approach allowed us to increase by at least a factor of five the signal-to-noise ratio in the faint limit (V>20.5mag). We took advantage of the new photometry index cU,B,I introduced by Monelli et al. (2014), as an age and probably a metallicity indicator, to split stars along the RGB. These two stellar populations display distinct [Fe/H] and [Mg/H] distributions: their mean Fe abundances are -2.15$\pm$0.06dex (sig=0.28), and -1.75$\pm$0.03dex (sig=0.21), respectively. The two iron distributions differ at the 75% level. This supports preliminary results by Lemasle et al. (2012) and by Monelli et al. (2014). Moreover, we found that the old and intermediate-age stellar populations have mean [Mg/H] abundances of -1.91$\pm$0.05dex (sig=0.22) and -1.35$\pm$0.03dex (sig=0.22); these differ at the 83% level. Carina's {\alpha}-element abundances agree, within 1sigma, with similar abundances for field Halo stars and for cluster (Galactic, Magellanic) stars. The same outcome applies to nearby dwarf spheroidals and ultra-faint dwarf galaxies, in the iron range covered by Carina stars. Finally, we found evidence of a clear correlation between Na and O abundances, thus suggesting that Carina's chemical enrichment history is quite different than in the globular clusters., Comment: 21 pages, 19 figures, 11 tables, accepted for publication in A&A
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- 2015
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21. On a new theoretical framework for RR Lyrae stars I: the metallicity dependence
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Marconi, M., Coppola, G., Bono, G., Braga, V., Pietrinferni, A., Buonanno, R., Castellani, M., Musella, I., Ripepi, V., and Stellingwerf, R. F.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present new nonlinear, time-dependent convective hydrodynamical models of RR Lyrae stars computed assuming a constant helium-to-metal enrichment ratio and a broad range in metal abundances (Z=0.0001--0.02). The stellar masses and luminosities adopted to construct the pulsation models were fixed according to detailed central He burning Horizontal Branch evolutionary models. The pulsation models cover a broad range in stellar luminosity and effective temperatures and the modal stability is investigated for both fundamental and first overtones. We predict the topology of the instability strip as a function of the metal content and new analytical relations for the edges of the instability strip in the observational plane. Moreover, a new analytical relation to constrain the pulsation mass of double pulsators as a function of the period ratio and the metal content is provided. We derive new Period-Radius-Metallicity relations for fundamental and first-overtone pulsators. They agree quite well with similar empirical and theoretical relations in the literature. From the predicted bolometric light curves, transformed into optical (UBVRI) and near-infrared (JHK) bands, we compute the intensity-averaged mean magnitudes along the entire pulsation cycle and, in turn, new and homogenous metal-dependent (RIJHK) Period-Luminosity relations. Moreover, we compute new dual and triple band optical, optical--NIR and NIR Period-Wesenheit-Metallicity relations. Interestingly, we find that the optical Period-W(V,B-V) is independent of the metal content and that the accuracy of individual distances is a balance between the adopted diagnostics and the precision of photometric and spectroscopic datasets., Comment: 51 pages, 20 figures, 9 tables, accepted for publication on ApJ
- Published
- 2015
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22. Volume Phase Holographic Lenses for Efficient Planar Solar Track-Concentrators
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Ferrara, M. A., Bianco, G., Striano, V., Coppola, G., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Di Francia, G., editor, Di Natale, C., editor, Alfano, B., editor, De Vito, S., editor, Esposito, E., editor, Fattoruso, G., editor, Formisano, F., editor, Massera, E., editor, Miglietta, M. L., editor, and Polichetti, T., editor
- Published
- 2020
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23. OC.07.9: ENDOSCOPIC BALLOON DILATION ASSOCIATED WITH BIOLOGICAL THERAPY IN CROHN'S DISEASE STRICTURES: A SINGLE CENTER EXPERIENCE
- Author
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Lopetuso, L.R., primary, Coppola, G., additional, Alfieri, N., additional, Morretta, C., additional, Di Vincenzo, F., additional, Puca, P., additional, Parisio, L., additional, Marmo, C., additional, Settanni, C.R., additional, Laterza, L., additional, Pugliese, D., additional, Riccioni, M.E., additional, Cammarota, G., additional, Papa, A., additional, Gasbarrini, A., additional, and Scaldaferri, F., additional
- Published
- 2024
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- View/download PDF
24. OC.07.8: THE POCER INDEX: APPLICATION OF A NOVEL ENDOSCOPIC SCORE IN A REAL-LIFE COHORT OF PATIENTS WITH CROHN'S DISEASE AFTER SURGERY
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Del Gaudio, A., primary, Parisio, L., additional, Cuccia, G., additional, Privitera, G., additional, Laterza, L., additional, Lopetuso, L.R., additional, Rumi, G., additional, De Biasio, F., additional, Mignini, I., additional, Coppola, G., additional, Gasbarrini, A., additional, Scaldaferri, F., additional, and Pugliese, D., additional
- Published
- 2024
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25. On the distance of the globular cluster M4 (NGC 6121) using RR Lyrae stars: I. optical and near-infrared Period-Luminosity and Period-Wesenheit relations
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Braga, V. F., Dall'Ora, M., Bono, G., Stetson, P. B., Ferraro, I., Iannicola, G., Marengo, M., Neeley, J., Persson, S. E., Buonanno, R., Coppola, G., Freedman, W., Madore, B. F., Marconi, M., Matsunaga, N., Monson, A., Rich, J., Scowcroft, V., and Seibert, M.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present new distance determinations to the nearby globular M4 (NGC~6121) based on accurate optical and Near Infrared (NIR) mean magnitudes for fundamental (FU) and first overtone (FO) RR Lyrae variables (RRLs), and new empirical optical and NIR Period-Luminosity (PL) and Period-Wesenheit (PW) relations. We have found that optical-NIR and NIR PL and PW relations are affected by smaller standard deviations than optical relations. The difference is the consequence of a steady decrease in the intrinsic spread of cluster RRL apparent magnitudes at fixed period as longer wavelengths are considered. The weighted mean visual apparent magnitude of 44 cluster RRLs is $\left
=13.329\pm0.001$ (standard error of the mean) $\pm$0.177 (weighted standard deviation) mag. Distances were estimated using RR Lyr itself to fix the zero-point of the empirical PL and PW relations. Using the entire sample (FU$+$FO) we found weighted mean true distance moduli of 11.35$\pm$0.03$\pm$0.05 mag and 11.32$\pm$0.02$\pm$0.07 mag. Distances were also evaluated using predicted metallicity dependent PLZ and PWZ relations. We found weighted mean true distance moduli of 11.283$\pm$0.010$\pm$0.018 mag (NIR PLZ) and 11.272$\pm$0.005$\pm$0.019 mag (optical--NIR and NIR PWZ). The above weighted mean true distance moduli agree within 1$\sigma$. The same result is found from distances based on PWZ relations in which the color index is independent of the adopted magnitude (11.272$\pm$0.004$\pm$0.013 mag). These distances agree quite well with the geometric distance provided by \citep{kaluzny2013} based on three eclipsing binaries. The available evidence indicates that this approach can provide distances to globulars hosting RRLs with a precision better than 2--3\%., Comment: Accepted for publication on ApJ - Published
- 2014
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26. STREGA: STRucture and Evolution of the GAlaxy. I. Survey Overview and First Results
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Marconi, M., Musella, I., Di Criscienzo, M., Cignoni, M., Dall'Ora, M., Bono, G., Ripepi, V., Brocato, E., Raimondo, G., Grado, A., Limatola, L., Coppola, G., Moretti, M. I., Stetson, P. B., Calamida, A., Cantiello, M., Capaccioli, M., Cappellaro, E., Cioni, M. -R. L., Degl'Innocenti, S., De Martino, D., Di Cecco, A., Ferraro, I., Iannicola, G., Moroni, P. G. Prada, Silvotti, R., Buonanno, R., Getman, F., Napolitano, N. R., Pulone, L., and Schipani, P.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
STREGA (STRucture and Evolution of the GAlaxy) is a Guaranteed Time survey being performed at the VST (the ESO VLT Survey Telescope) to map about 150 square degrees in the Galactic halo, in order to constrain the mechanisms of galactic formation and evolution. The survey is built as a five-year project, organized in two parts: a core program to explore the surrounding regions of selected stellar systems and a second complementary part to map the southern portion of the Fornax orbit and extend the observations of the core program. The adopted stellar tracers are mainly variable stars (RR~Lyraes and Long Period Variables) and Main Sequence Turn-off stars for which observations in the g,r,i bands are obtained. We present an overview of the survey and some preliminary results for three observing runs that have been completed. For the region centered on $\omega$~Cen (37 deg^2), covering about three tidal radii, we also discuss the detected stellar density radial profile and angular distribution, leading to the identification of extratidal cluster stars. We also conclude that the cluster tidal radius is about 1.2 deg, in agreement with values in the literature based on the Wilson model., Comment: Accepted for publication on MNRAS on 2014 August 18
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- 2014
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27. Amyloid in dementia associated with familial FTLD: not an innocent bystander
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Naasan, G, Rabinovici, GD, Ghosh, P, Elofson, JD, Miller, BL, Coppola, G, Karydas, A, Fong, J, Perry, D, Lee, SE, Yokoyama, JS, Seeley, WW, Kramer, JH, Weiner, MW, Schuff, N, Jagust, WJ, Grinberg, LT, Pribadi, M, Yang, Z, Sears, R, Klein, E, Wojta, K, and Rosen, HJ
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Clinical Sciences ,Psychology ,Cognitive Sciences ,Experimental Psychology ,Neurosciences ,Biological psychology ,Clinical and health psychology - Abstract
Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.
- Published
- 2016
28. An Analysis of Time-Integration Errors in Large-Eddy Simulation of Incompressible Turbulent Flows
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Capuano, F., De Angelis, E. M., Coppola, G., de Luca, L., Geurts, Bernard, Series Editor, Salvetti, Maria Vittoria, Series Editor, Armenio, Vincenzo, editor, Fröhlich, Jochen, editor, Geurts, Bernard J., editor, and Kuerten, Hans, editor
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- 2019
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29. Discrete Conservation of Helicity in Numerical Simulations of Incompressible Turbulent Flows
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Vallefuoco, D., Capuano, F., Coppola, G., Geurts, Bernard, Series Editor, Salvetti, Maria Vittoria, Series Editor, Armenio, Vincenzo, editor, Fröhlich, Jochen, editor, Geurts, Bernard J., editor, and Kuerten, Hans, editor
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- 2019
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30. GDF10 is a signal for axonal sprouting and functional recovery after stroke
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Li, S, Nie, EH, Yin, Y, Benowitz, LI, Tung, S, Vinters, HV, Bahjat, FR, Stenzel-Poore, MP, Kawaguchi, R, Coppola, G, and Carmichael, ST
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Neurology & Neurosurgery ,Neurosciences ,Psychology ,Cognitive Sciences - Abstract
Stroke produces a limited process of neural repair. Axonal sprouting in cortex adjacent to the infarct is part of this recovery process, but the signal that initiates axonal sprouting is not known. Growth and differentiation factor 10 (GDF10) is induced in peri-infarct neurons in mice, non-human primates and humans. GDF10 promotes axonal outgrowth in vitro in mouse, rat and human neurons through TGFβRI and TGFβRII signaling. Using pharmacogenetic gain- and loss-of-function studies, we found that GDF10 produced axonal sprouting and enhanced functional recovery after stroke; knocking down GDF10 blocked axonal sprouting and reduced recovery. RNA sequencing from peri-infarct cortical neurons revealed that GDF10 downregulated PTEN, upregulated PI3 kinase signaling and induced specific axonal guidance molecules. Using unsupervised genome-wide association analysis of the GDF10 transcriptome, we found that it was not related to neurodevelopment, but may partially overlap with other CNS injury patterns. Thus, GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
- Published
- 2015
31. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease
- Author
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Lalli, MA, Bettcher, BM, Arcila, ML, Garcia, G, Guzman, C, Madrigal, L, Ramirez, L, Acosta-Uribe, J, Baena, A, Wojta, KJ, Coppola, G, Fitch, R, De Both, MD, Huentelman, MJ, Reiman, EM, Brunkow, ME, Glusman, G, Roach, JC, Kao, AW, Lopera, F, and Kosik, KS
- Subjects
Psychiatry ,Medical and Health Sciences ,Biological Sciences ,Psychology and Cognitive Sciences - Abstract
We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onset (AAO) of Alzheimer's disease. Our analysis identified a haplotype of single-nucleotide polymorphisms (SNPs) on chromosome 17 within a chemokine gene cluster associated with delayed onset of mild-cognitive impairment and dementia. Individuals carrying this haplotype had a mean AAO of mild-cognitive impairment at 51.0±5.2 years compared with 41.1±7.4 years for those without these SNPs. This haplotype thus appears to modify Alzheimer's AAO, conferring a large (∼10 years) protective effect. The associated locus harbors several chemokines including eotaxin-1 encoded by CCL11, and the haplotype includes a missense polymorphism in this gene. Validating this association, we found plasma eotaxin-1 levels were correlated with disease AAO in an independent cohort from the University of California San Francisco Memory and Aging Center. In this second cohort, the associated haplotype disrupted the typical age-associated increase of eotaxin-1 levels, suggesting a complex regulatory role for this haplotype in the general population. Altogether, these results suggest eotaxin-1 as a novel modifier of Alzheimer's disease AAO and open potential avenues for therapy.
- Published
- 2015
32. Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
- Author
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Lehmann, M, Madison, C, Ghosh, PM, Miller, ZA, Greicius, MD, Kramer, JH, Coppola, G, Miller, BL, Jagust, WJ, Gorno-Tempini, ML, Seeley, WW, and Rabinovici, GD
- Subjects
Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
The common and specific involvement of brain networks in clinical variants of Alzheimer's disease (AD) is not well understood. We performed task-free ("resting-state") functional imaging in 60 nonfamilial AD patients, including 20 early-onset AD (age at onset
- Published
- 2015
33. Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR.
- Author
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Oguro-Ando, A, Rosensweig, C, Herman, E, Nishimura, Y, Werling, D, Bill, BR, Berg, JM, Gao, F, Coppola, G, Abrahams, BS, and Geschwind, DH
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Dendritic Spines ,Dendritic Cells ,Cells ,Cultured ,Chromosomes ,Human ,Pair 15 ,Animals ,Mice ,Inbred C57BL ,Mice ,Transgenic ,Humans ,Mice ,Adaptor Proteins ,Signal Transducing ,Signal Transduction ,Gene Expression Regulation ,Up-Regulation ,Female ,Fragile X Mental Retardation Protein ,DNA Copy Number Variations ,TOR Serine-Threonine Kinases ,Autism Spectrum Disorder ,Genetics ,Pediatric ,Brain Disorders ,Mental Health ,Autism ,Neurosciences ,Intellectual and Developmental Disabilities (IDD) ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Rare maternally inherited duplications at 15q11-13 are observed in ~1% of individuals with an autism spectrum disorder (ASD), making it among the most common causes of ASD. 15q11-13 comprises a complex region, and as this copy number variation encompasses many genes, it is important to explore individual genotype-phenotype relationships. Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is of particular interest because of its interaction with Fragile X mental retardation protein (FMRP), its upregulation in transformed lymphoblastoid cell lines from patients with duplications at 15q11-13 and ASD and the presence of smaller overlapping deletions of CYFIP1 in patients with schizophrenia and intellectual disability. Here, we confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time. To investigate how increased CYFIP1 dosage might predispose to neurodevelopmental disease, we studied the consequence of its overexpression in multiple systems. We show that overexpression of CYFIP1 results in morphological abnormalities including cellular hypertrophy in SY5Y cells and differentiated mouse neuronal progenitors. We validate these results in vivo by generating a BAC transgenic mouse, which overexpresses Cyfip1 under the endogenous promotor, observing an increase in the proportion of mature dendritic spines and dendritic spine density. Gene expression profiling on embryonic day 15 suggested the dysregulation of mammalian target of rapamycin (mTOR) signaling, which was confirmed at the protein level. Importantly, similar evidence of mTOR-related dysregulation was seen in brains from 15q11-13 duplication patients with ASD. Finally, treatment of differentiated mouse neuronal progenitors with an mTOR inhibitor (rapamycin) rescued the morphological abnormalities resulting from CYFIP1 overexpression. Together, these data show that CYFIP1 overexpression results in specific cellular phenotypes and implicate modulation by mTOR signaling, further emphasizing its role as a potential convergent pathway in some forms of ASD.
- Published
- 2015
34. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS
- Author
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Omura, T, Omura, K, Tedeschi, A, Riva, P, Painter, MW, Rojas, L, Martin, J, Lisi, V, Huebner, EA, Latremoliere, A, Yin, Y, Barrett, LB, Singh, B, Lee, S, Crisman, T, Gao, F, Li, S, Kapur, K, Geschwind, DH, Kosik, KS, Coppola, G, He, Z, Carmichael, ST, Benowitz, LI, Costigan, M, and Woolf, CJ
- Subjects
Neurology & Neurosurgery ,Neurosciences ,Cognitive Sciences ,Psychology - Abstract
Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability. Omura et al. screened for neuronal growth on myelin and find CAST/Ei inbred mice are uniquely able to regenerate axons in the injured CNS through Activin signaling. Enhancing Activin signaling confers a CNS-regenerative capacity in normally non-regenerative mouse strains.
- Published
- 2015
35. Novel candidate blood-based transcriptional biomarkers of machado-joseph disease
- Author
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Raposo, M, Bettencourt, C, Maciel, P, Gao, F, Ramos, A, Kazachkova, N, Vasconcelos, J, Kay, T, Rodrigues, AJ, Bettencourt, B, Bruges-Armas, J, Geschwind, D, Coppola, G, and Lima, M
- Subjects
Neurology & Neurosurgery ,Clinical Sciences ,Human Movement and Sports Sciences ,Neurosciences - Abstract
Background: Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3. Previous studies on cell and animal models have suggested that mutated ataxin-3 is involved in transcriptional dysregulation. Starting with a whole-transcriptome profiling of peripheral blood samples from patients and controls, we aimed to confirm abnormal expression profiles in Machado-Joseph disease and to identify promising up-regulated genes as potential candidate biomarkers of disease status. Methods: The Illumina Human V4-HT12 array was used to measure transcriptome-wide gene expression in peripheral blood samples from 12 patients and 12 controls. Technical validation and validation in an independent set of samples were performed by quantitative real-time polymerase chain reaction (PCR). Results: Based on the results from the microarray, twenty six genes, found to be up-regulated in patients, were selected for technical validation by quantitative real-time PCR (validation rate of 81% for the up-regulation trend). Fourteen of these were further tested in an independent set of 42 patients and 35 controls; 10 genes maintained the up-regulation trend (FCGR3B, CSR2RA, CLC, TNFSF14, SLA, P2RY13, FPR2, SELPLG, YIPF6, and GPR96); FCGR3B, P2RY13, and SELPLG were significantly up-regulated in patients when compared with controls. Conclusions: Our findings support the hypothesis that mutated ataxin-3 is associated with transcription dysregulation, detectable in peripheral blood cells. Furthermore, this is the first report suggesting a pool of up-regulated genes in Machado-Joseph disease that may have the potential to be used for fine phenotyping of this disease.
- Published
- 2015
36. The Carina Project. VI. The helium burning variable stars
- Author
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Coppola, G., Stetson, P. B., Marconi, M., Bono, G., Ripepi, V., Fabrizio, M., Dall'Ora, M., Musella, I., Buonanno, R., Ferraro, I., Fiorentino, G., Iannicola, G., Monelli, M., Nonino, M., Pulone, I., Thévenin, F., and Walker, A. R.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present new optical (BVI) time-series data for the evolved variable stars in the Carina dwarf spheroidal galaxy. The quality of the data and the observing strategy allowed us to identify 14 new variable stars. Eight out of the 14 are RR Lyrae (RRL) stars, four are Anomalous Cepheids (ACs) and two are geometrical variables. Comparison of the period distribution for the entire sample of RRLs with similar distributions in nearby dSphs and in the Large Magellanic Cloud indicates that the old stellar populations in these systems share similar properties. This finding is also supported by the RRL distribution in the Bailey diagram. On the other hand, the period distribution and the Bailey diagram of ACs display significant differences among the above stellar systems. This evidence suggests that the properties of intermediate-age stellar populations might be affected both by environmental effects and structural parameters. We use the BV Period--Wesenheit (PW) relation of RRLs together with evolutionary prescriptions and find a true distance modulus of 20.09+/-0.07(intrinsic)+/-0.1(statistical) mag that agrees quite well with similar estimates available in the literature. We identified four peculiar variables. Taking into account their position in the Bailey diagram and in the BV PW relation, two of them (V14, V149) appear to be candidate ACs, while two (V158, V182) might be peculiar RRLs. In particular, the variable V158 has a period and a V-band amplitude very similar to the low-mass RRL ---RRLR-02792---recently identified by Pietrzynski at al. (2012) in the Galactic bulge., Comment: Accepted for publication in ApJ, publication date September 20, 2013. 31 pages, 7 figure, 3 tables. Figs. 3 and 4 corrected, references added, minor corrections
- Published
- 2013
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37. Numerically stable formulations of convective terms for turbulent compressible flows
- Author
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Coppola, G., Capuano, F., Pirozzoli, S., and de Luca, L.
- Published
- 2019
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38. Shedding Light on Diatom Photonics by means of Digital Holography
- Author
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Di Caprio, Giuseppe, Coppola, G., De Stefano, L., De Stefano, M., Antonucci, A., Congestri, R., and De Tommasi, E.
- Subjects
Physics - Optics ,Physics - Biological Physics - Abstract
Diatoms are among the dominant phytoplankters in the worl's ocean, and their external silica investments, resembling artificial photonics crystal, are expected to play an active role in light manipulation. Digital holography allowed studying the interaction with light of Coscinodiscus wailesii cell wall reconstructing the light confinement inside the cell cytoplasm, condition that is hardly accessible via standard microscopy. The full characterization of the propagated beam, in terms of quantitative phase and intensity, removed a long-standing ambiguity about the origin of the light. The data were discussed in the light of living cell behavior in response to their environment.
- Published
- 2012
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39. Distance to Galactic globulars using the near-infrared magnitudes of RR Lyrae stars: IV. The case of M5 (NGC5904)
- Author
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Coppola, G., Dall'Ora, M., Ripepi, V., Marconi, M., Musella, I., Bono, G., Piersimoni, A. M., Stetson, P. B., and Storm, J.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present new and accurate near-infrared (NIR) J, K-band time series data for the Galactic globular cluster (GC) M5 = NGC5904. Data were collected with SOFI at the NTT (71 J + 120 K images) and with NICS at the TNG (25 J + 22 K images) and cover two orthogonal strips across the center of the cluster of \approx 5 \times 10 arcmin^{2} each. These data allowed us to derive accurate mean K-band magnitudes for 52 fundamental (RR_{ab}) and 24 first overtone (RR_{c}) RR Lyrae stars. Using this sample of RR Lyrae stars, we find that the slope of the K-band Period Luminosity (PLK) relation (-2.33 \pm 0.08) agrees quite well with similar estimates available in the literature. We also find, using both theoretical and empirical calibrations of the PLK relation, a true distance to M5 of (14.44 \pm 0.02) mag. This distance modulus agrees very well (1\sigma) with distances based on main sequence fitting method and on kinematic method (14.44 \pm 0.41 mag, \citealt{rees_1996}), while is systematically smaller than the distance based on the white dwarf cooling sequence (14.67 \pm 0.18 mag, \citealt{layden2005}), even if with a difference slightly larger than 1\sigma. The true distance modulus to M5 based on the PLJ relation (14.50 \pm 0.08 mag) is in quite good agreement with the distance based on the PLK relation further supporting the use of NIR PL relations for RR Lyrae stars to improve the precision of the GC distance scale., Comment: 19 pages, 6 figures, accepted for publication in MNRAS
- Published
- 2011
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40. Sersic galaxy with Sersic halo models of early-type galaxies: a tool for N-body simulations
- Author
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Coppola, G., La Barbera, F., and Capaccioli, M.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present spherical, non-rotating, isotropic models of early-type galaxies with stellar and dark-matter components both described by deprojected Sersic density profiles, and prove that they represent physically admissible stable systems. Using empirical correlations and recent results of N-body simulations, all the free parameters of the models are expressed as functions of one single quantity: the total (B-band) luminosity of the stellar component. We analyze how to perform discrete N-body realizations of Sersic models. To this end, an optimal smoothing length is derived, defined as the softening parameter minimizing the error on the gravitational potential for the deprojected Sersic model. It is shown to depend on the Sersic index $n$ and on the number of particles of the N-body realization. A software code allowing the computations of the relevant quantities of one- and two-component Sersic models is provided. Both the code and the results of the present work are primarily intended as tools to perform N-body simulations of early-type galaxies, where the structural non-homology of these systems (i.e. the variation of the shape parameter along the galaxy sequence) might be taken into account., Comment: 14 pages, 9 figures, 1 table, accepted for publication in PASP
- Published
- 2009
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41. P750 Endoscopic balloon dilation associated with biological therapy in Crohn's Disease strictures: a single center experience
- Author
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Lopetuso, L R, primary, Coppola, G, additional, Alfieri, N, additional, Morretta, C, additional, Di Vincenzo, F, additional, Puca, P, additional, Parisio, L, additional, Marmo, C, additional, Settanni, C R, additional, Laterza, L, additional, Pugliese, D, additional, Riccioni, M E, additional, Cammarota, G, additional, Papa, A, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional
- Published
- 2024
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- View/download PDF
42. P460 The POCER index: application of a novel endoscopic score in a real-life cohort of patients with Crohn's disease after surgery
- Author
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Parisio, L, primary, Del Gaudio, A, additional, Privitera, G, additional, Cuccia, G, additional, Lopetuso, L R, additional, Laterza, L, additional, Rumi, G, additional, De Biasio, F, additional, Mignini, I, additional, Calvez, V, additional, Coppola, G, additional, Gasbarrini, A, additional, Scaldaferri, F, additional, and Pugliese, D, additional
- Published
- 2024
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- View/download PDF
43. P1213 The effects of Escherichia coli Nissle 1917 on the gut microbiota composition in ulcerative colitis patients
- Author
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Puca, P, primary, Del Chierico, F, additional, Graziani, C, additional, Masi, L, additional, Coppola, G, additional, Di Vincenz, F, additional, Capobianco, I, additional, Lopetuso, L R, additional, Barbaro, M R, additional, Masucci, L, additional, Putignani, L, additional, Petito, V, additional, Marasco, G, additional, Sanguinetti, M, additional, Barbara, G, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional
- Published
- 2024
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44. P831 Acute infusion reactions due to different biologic agents in a large cohort of patients with Inflammatory Bowel Disease
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Colantuono, S, primary, Caruso, C, additional, Rumi, G, additional, Capobianco, I, additional, Blasi, V, additional, Termite, F, additional, Coppola, G, additional, Laterza, L, additional, Lopetuso, L R, additional, Mignini, I, additional, Napolitano, D, additional, Parisio, L, additional, Pugliese, D, additional, Scaldaferri, F, additional, Gasbarrini, A, additional, and Papa, A, additional
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- 2024
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45. Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia
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Butler, P.M., Chiong, W., Perry, D.C., Miller, Z.A., Gennatas, E.D., Brown, J.A., Pasquini, L., Karydas, A., Dokuru, D., Coppola, G., Sturm, V.E., Boxer, A.L., Gorno-Tempini, M.L., Rosen, H.J., Kramer, J.H., Miller, B.L., and Seeley, W.W.
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- 2019
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46. Monitoring And Managing Depression In Adolescents With Epilepsy: Current Perspectives
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Coppola G, Operto FF, Matricardi S, and Verrotti A
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depression ,adolescents ,monitoring ,management ,epilepsy ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Giangennaro Coppola,1 Francesca Felicia Operto,1 Sara Matricardi,2 Alberto Verrotti3 1Child and Adolescent Neuropsychiatry, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, Salerno, Italy; 2Department of Pediatric Neurology, Ospedali Riuniti, Ancona, Italy; 3Department of Pediatrics, University of L’Aquila, L’Aquila, ItalyCorrespondence: Giangennaro CoppolaChild and Adolescent Neuropsychiatry, Department of Medicine, Surgery and Odontoiatry, University of Salerno, Largo d’Ippocrate, 1, Salerno 84100, ItalyTel/Fax +39 089672578Email gcoppola@unisa.itAbstract: Epilepsy is associated with a significantly increased risk of developing depressive disorder during adolescence. On the other hand, depression is highly detected in adolescents with epilepsy. These findings highlight the importance of early identification and proper management of comorbid depression in adolescent age. The prevalence of depressive disorders in adolescents with epilepsy ranges between 8 and 35% and is higher than the general population of the same age. The relationship between epilepsy and depression is complex and potentially bidirectional, thereby suggesting a common underlying pathophysiology. Furthermore, failure to detect and treat depressive disorder mostly in adolescence could lead to several negative implications such as an increased risk of suicidal ideation or behavior and poor quality of life. A number of methods are available to detect depressive disorder, such as psychiatric or psychological assessments, structured or semi-structured interviews, and self-report screening tools. Thus, physicians should be able to regularly screen depressive symptoms in youths with epilepsy. Recently, the NDDI-E-.Y inventory has been developed from the adult NDDI-E, and has been validated in many countries. NDDI-E-Y has showed reliable validity, being a brief screening tool (12 items) that can be easily included in routine epilepsy care. The first step to be considered for the management of depressive disorder in adolescents with epilepsy is to consider potential reversible causes of anxiety and depression (i.e., a new AEDs; seizure control). Secondly, great attention has to be given to the education of the child/adolescent and his/her family, trying to improve knowledge about epilepsy as well as to decrease parental stress and improving the child’s sense of competence. Pharmacological treatment should also be considered in adolescents diagnosed with depression.Keywords: depression, adolescents, monitoring, management, epilepsy
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- 2019
47. The SDSS-UKIDSS Fundamental Plane of Early-type Galaxies
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La Barbera, F., Busarello, G., Merluzzi, P., de la Rosa, I., Coppola, G., and Haines, C. P.
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Astrophysics - Abstract
We derive the Fundamental Plane (FP) relation for a sample of 1430 early-type galaxies in the optical (r band) and the near-infrared (K band), by combining SDSS and UKIDSS data. With such a large, homogeneous dataset, we are able to assess the dependence of the FP on the waveband. Our analysis indicates that the FP of luminous early-type galaxies is essentially waveband independent, with its coefficients increasing at most by 8% from the optical to the NIR. This finding fits well into a consistent picture where the tilt of the FP is not driven by stellar populations, but results from other effects, such as non-homology. In this framework, the optical and NIR FPs require more massive galaxies to be slightly more metal rich than less massive ones, and to have highly synchronized ages, with an age variation per decade in mass smaller than a few percent., Comment: 7 pages, 2 figures, accepted for publication on ApJ
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- 2008
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48. Pseudo-symplectic numerical schemes for Landau-Lifshitz dynamics
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d’Aquino, M., Capuano, F., Coppola, G., Serpico, C., and Mayergoyz, I.D.
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- 2018
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49. Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects
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Almeida, S, Zhang, Z, Coppola, G, Mao, W, Futai, K, Karydas, A, Geschwind, MD, Tartaglia, MC, Gao, F, Gianni, D, Sena-Esteves, M, Geschwind, DH, Miller, BL, Farese, RV, and Gao, FB
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Biochemistry and Cell Biology ,Medical Physiology - Published
- 2012
50. Electro-drawn polymer microneedle arrays with controlled shape and dimension
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Ruggiero, F., Vecchione, R., Bhowmick, S., Coppola, G., Coppola, S., Esposito, E., Lettera, V., Ferraro, P., and Netti, P.A.
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- 2018
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