Search

Your search keyword '"Coral-Vazquez, Ramón"' showing total 33 results
Start Over Author "Coral-Vazquez, Ramón"
33 results on '"Coral-Vazquez, Ramón"'

7. Reconstructing Native American population history

Author

Reich, David, Patterson, Nick, Campbell, Desmond, Tandon, Arti, Mazieres, Stéphane, Ray, Nicolas, Parra, Maria V, Rojas, Winston, Duque, Constanza, Mesa, Natalia, García, Luis F, Triana, Omar, Blair, Silvia, Maestre, Amanda, Dib, Juan C, Bravi, Claudio M, Bailliet, Graciela, Corach, Daniel, Hünemeier, Tábita, Bortolini, Maria Cátira, Salzano, Francisco M, Petzl-Erler, María Luiza, Acuña-Alonzo, Victor, Aguilar-Salinas, Carlos, Canizales-Quinteros, Samuel, Tusié-Luna, Teresa, Riba, Laura, Rodríguez-Cruz, Maricela, Lopez-Alarcón, Mardia, Coral-Vazquez, Ramón, Canto-Cetina, Thelma, Silva-Zolezzi, Irma, Fernandez-Lopez, Juan Carlos, Contreras, Alejandra V, Jimenez-Sanchez, Gerardo, Gómez-Vázquez, Maria José, Molina, Julio, Carracedo, Ángel, Salas, Antonio, Gallo, Carla, Poletti, Giovanni, Witonsky, David B, Alkorta-Aranburu, Gorka, Sukernik, Rem I, Osipova, Ludmila, Fedorova, Sardana A, Vasquez, René, Villena, Mercedes, Moreau, Claudia, Barrantes, Ramiro, Pauls, David, Excoffier, Laurent, Bedoya, Gabriel, Rothhammer, Francisco, Dugoujon, Jean-Michel, Larrouy, Georges, Klitz, William, Labuda, Damian, Kidd, Judith, Kidd, Kenneth, Di Rienzo, Anna, Freimer, Nelson B, Price, Alkes L, and Ruiz-Linares, Andrés

Subjects
Biological Sciences, Genetics, History, Heritage and Archaeology, Human Society, Historical Studies, Anthropology, American Indian or Alaska Native, Americas, Asia, Cluster Analysis, Emigration and Immigration, Gene Flow, Genetics, Population, History, Ancient, Humans, Indians, North American, Models, Genetic, Phylogeny, Polymorphism, Single Nucleotide, Siberia, General Science & Technology
Abstract

The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call 'First American'. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.

Published
2012

27. Erratum: Corrigendum: Reconstructing Native American population history

Author

Reich, David, primary, Patterson, Nick, additional, Campbell, Desmond, additional, Tandon, Arti, additional, Mazieres, Stéphane, additional, Ray, Nicolas, additional, Parra, Maria V., additional, Rojas, Winston, additional, Duque, Constanza, additional, Mesa, Natalia, additional, García, Luis F., additional, Triana, Omar, additional, Blair, Silvia, additional, Maestre, Amanda, additional, Dib, Juan C., additional, Bravi, Claudio M., additional, Bailliet, Graciela, additional, Corach, Daniel, additional, Hünemeier, Tábita, additional, Bortolini, Maria Cátira, additional, Salzano, Francisco M., additional, Petzl-Erler, María Luiza, additional, Acuña-Alonzo, Victor, additional, Aguilar-Salinas, Carlos, additional, Canizales-Quinteros, Samuel, additional, Tusié-Luna, Teresa, additional, Riba, Laura, additional, Rodríguez-Cruz, Maricela, additional, Lopez-Alarcón, Mardia, additional, Coral-Vazquez, Ramón, additional, Canto-Cetina, Thelma, additional, Silva-Zolezzi, Irma, additional, Fernandez-Lopez, Juan Carlos, additional, Contreras, Alejandra V., additional, Jimenez-Sanchez, Gerardo, additional, Gómez-Vázquez, Maria José, additional, Molina, Julio, additional, Carracedo, Ángel, additional, Salas, Antonio, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, B.Witonsky, David, additional, Alkorta-Aranburu, Gorka, additional, Sukernik, Rem I., additional, Osipova, Ludmila, additional, Fedorova, Sardana A., additional, Vasquez, René, additional, Villena, Mercedes, additional, Moreau, Claudia, additional, Barrantes, Ramiro, additional, Pauls, David, additional, Excoffier, Laurent, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Dugoujon, Jean-Michel, additional, Larrouy, Georges, additional, Klitz, William, additional, Labuda, Damian, additional, Kidd, Judith, additional, Kidd, Kenneth, additional, Di Rienzo, Anna, additional, Freimer, Nelson B., additional, Price, Alkes L., additional, and Ruiz-Linares, Andrés, additional

Published
2012
Full Text
View/download PDF

30. Reconstructing Native American Population History

Author

Reich, David Emil, Patterson, Nick, Campbell, Desmond, Tandon, Arti, Mazieres, Stéphane, Ray, Nicolas, Parra, Maria V., Rojas, Winston, Duque, Constanza, Mesa, Natalia, García, Luis F., Triana, Omar, Blair, Silvia, Maestre, Amanda, Dib, Juan C., Bravi, Claudio M., Bailliet, Graciela, Corach, Daniel, Hünemeier, Tábita, Bortolini, Maria-Cátira, Salzano, Francisco M., Petzl-Erler, María Luiza, Acuña-Alonzo, Victor, Aguilar-Salinas, Carlos, Canizales-Quinteros, Samuel, Tusié-Luna, Teresa, Riba, Laura, Rodríguez-Cruz, Maricela, Lopez-Alarcón, Mardia, Coral-Vazquez, Ramón, Canto-Cetina, Thelma, Silva-Zolezzi, Irma, Fernandez-Lopez, Juan Carlos, Contreras, Alejandra V., Jimenez-Sanchez, Gerardo, Gómez-Vázquez, María José, Molina, Julio, Carracedo, Ángel, Salas, Antonio, Gallo, Carla, Poletti, Giovanni, Witonsky, David B., Alkorta-Aranburu, Gorka, Sukernik, Rem I., Osipova, Ludmila, Fedorova, Sardana, Vasquez, René, Villena, Mercedes, Moreau, Claudia, Barrantes, Ramiro, Pauls, David L., Excoffier, Laurent, Bedoya, Gabriel, Rothhammer, Francisco, Dugoujon, Jean Michel, Larrouy, Georges, Klitz, William, Labuda, Damian, Kidd, Judith, Kidd, Kenneth, Rienzo, Anna Di, Freimer, Nelson B., Price, Alkes, and Ruiz-Linares, Andrés

Abstract

The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1–5. One contentious issue is whether the settlement occurred via a single6–8 or multiple streams of migration from Siberia9–15. The pattern of dispersals within the Americas is also poorly understood. To address these questions at higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. We show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call “First American”. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan-speakers on both sides of the Panama Isthmus, who have ancestry from both North and South America.

Published
2013
Full Text
View/download PDF

32. Non-Invasive Biomarkers for Duchenne Muscular Dystrophy and Carrier Detection.

Author

Anaya-Segura MA, García-Martínez FA, Montes-Almanza LA, Díaz BG, Avila-Ramírez G, Alvarez-Maya I, Coral-Vazquez RM, Mondragón-Terán P, Escobar-Cedillo RE, García-Calderón N, Vazquez-Cardenas NA, García S, and López-Hernandez LB

Subjects
Biomarkers, Case-Control Studies, Child, Child, Preschool, Extracellular Matrix Proteins blood, Extracellular Matrix Proteins metabolism, Female, Humans, Muscle, Skeletal metabolism, Muscular Dystrophy, Duchenne diagnosis, Sensitivity and Specificity, Heterozygote, Muscular Dystrophy, Duchenne genetics, Muscular Dystrophy, Duchenne metabolism
Abstract

Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biomarker with both high sensitivity and specificity for accurate prediction is preferred. Until now creatine kinase (CK) levels have been used for DMD diagnosis but these fail to assess disease progression. Herein we examined the potential applicability of serum levels of matrix metalloproteinase 9 and matrix metalloproteinase 2, tissue inhibitor of metalloproteinases 1, myostatin (GDF-8) and follistatin (FSTN) as non-invasive biomarkers to distinguish between DMD steroid naïve patients and healthy controls of similar age and also for carrier detection. Our data suggest that serum levels of MMP-9, GDF-8 and FSTN are useful to discriminate DMD from controls (p < 0.05), to correlate with some neuromuscular assessments for DMD, and also to differentiate between Becker muscular dystrophy (BMD) and Limb-girdle muscular dystrophy (LGMD) patients. In DMD individuals under steroid treatment, GDF-8 levels increased as FSTN levels decreased, resembling the proportions of these proteins in healthy controls and also the baseline ratio of patients without steroids. GDF-8 and FSTN serum levels were also useful for carrier detection (p < 0.05). Longitudinal studies with larger cohorts are necessary to confirm that these molecules correlate with disease progression. The biomarkers presented herein could potentially outperform CK levels for carrier detection and also harbor potential for monitoring disease progression.

Published
2015
Full Text
View/download PDF

33. Identification of novel mutations in the RB1 gene in Mexican patients with retinoblastoma.

Author

Rodríguez M, Salcedo M, González M, Coral-Vazquez R, Salamanca F, and Arenas D

Subjects
Base Sequence, Exons genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Mexico, Polymorphism, Single-Stranded Conformational, Mutation genetics, Retinoblastoma genetics, Retinoblastoma Protein genetics
Abstract

Retinoblastoma (RB) is a childhood tumor of the eye with an average incidence of one case in every 15,000-20,000 live births and occurs in sporadic or hereditary form. This cancer results from loss or inactivation of the RB1 gene located at 13q14.1. This gene encodes for a 110 Kd nuclear phosphoprotein (pRB) that plays a major role in cell proliferation control. Different types of mutations in the RB1 gene have been reported, but point mutations are the most common. There are no molecular studies on RB1 gene mutation in Mexican patients. In this study, 19 patients with bilateral or unilateral RB were analyzed. Genetic and cytogenetic studies were carried out. Detection of RB1 gene mutations was done using single-strand conformational polymorphism (SSCP). Five conformational polymorphisms were identified in different exons. In all cases, SSCP sequence showed new non-described mutations that produced a frameshift on the open reading frame. The identification of mutations in the RB1 gene contributes to basic knowledge of this neoplasia and permits the possibility to offer adequate genetic counseling to relatives at risk.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results