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3. Peripheral blood allogeneic stem cell mobilization: can we predict a suboptimal mobilization?

Author

Piccirillo, Nicola, primary, Putzulu, Rossana, additional, Metafuni, Elisabetta, additional, Massini, Giuseppina, additional, Fatone, Federica, additional, Corbingi, Andrea, additional, Giammarco, Sabrina, additional, Limongiello, Maria Assunta, additional, Giovanni, Alessia Di, additional, Zini, Gina, additional, Bacigalupo, Andrea, additional, Teofili, Luciana, additional, Sica, Simona, additional, and Chiusolo, Patrizia, additional

Published
2023
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4. Successful stem cell collection for atypical teratoid rhabdoid tumor in an extremely low‐body weight child: A case report

Author

Putzulu, Rossana, primary, Romano, Alberto, additional, Mancino, Aldo, additional, Corbingi, Andrea, additional, Massini, Giuseppina, additional, Mastrangelo, Stefano, additional, Pulitanò, Silvia Maria, additional, Piastra, Marco, additional, Pittiruti, Mauro, additional, Ruggiero, Antonio, additional, and Piccirillo, Nicola, additional

Published
2023
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5. Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Author

Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, Todisco, Elisabetta, Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, and Todisco, Elisabetta

Published
2023

6. Successful stem cell collection for atypical teratoid rhabdoid tumor in an extremely low-body weight child: A case report

Author

Putzulu, Rossana, Romano, Alberto, Mancino, Aldo, Corbingi, Andrea, Massini, Giuseppina, Mastrangelo, Stefano, Pulitano', Silvia Maria, Piastra, Marco, Pittiruti, Mauro, Ruggiero, Antonio, Piccirillo, Nicola, Mastrangelo, Stefano (ORCID:0000-0002-3305-6014), Pulitanò, Silvia Maria (ORCID:0000-0002-8496-379X), Piastra, Marco (ORCID:0000-0002-3144-8970), Pittiruti, Mauro (ORCID:0000-0003-4541-7566), Ruggiero, Antonio (ORCID:0000-0002-6052-3511), Piccirillo, Nicola (ORCID:0000-0002-1688-1987), Putzulu, Rossana, Romano, Alberto, Mancino, Aldo, Corbingi, Andrea, Massini, Giuseppina, Mastrangelo, Stefano, Pulitano', Silvia Maria, Piastra, Marco, Pittiruti, Mauro, Ruggiero, Antonio, Piccirillo, Nicola, Mastrangelo, Stefano (ORCID:0000-0002-3305-6014), Pulitanò, Silvia Maria (ORCID:0000-0002-8496-379X), Piastra, Marco (ORCID:0000-0002-3144-8970), Pittiruti, Mauro (ORCID:0000-0003-4541-7566), Ruggiero, Antonio (ORCID:0000-0002-6052-3511), and Piccirillo, Nicola (ORCID:0000-0002-1688-1987)

Abstract

The use of peripheral blood hematopoietic stem cells for bone marrow reconstitution after myeloablative therapy is well established in children with malignant disorders. However, the peripheral blood hematopoietic stem cells collection in very low-body weight (<= 10 kg) children remains a significant challenge because of technical and clinical issues. A male newborn affected by atypical teratoid rhabdoid tumor, diagnosed prenatally, received two cycles of chemotherapy following surgical resection. After an interdisciplinary discussion, it was decided to intensify the treatment with high-dose chemotherapy followed by autologous stem cell transplantation. After 7 days of G-CSF administration the patient underwent hematopoietic progenitor cells-apheresis collection. The procedure was performed in the pediatric intensive care unit, using two central venous catheters and Spectra Optia device. The cell collection procedure was completed in 200 min, during which time 3.9 total blood volumes were processed. During apheresis we did not observe electrolyte alterations. No adverse events were recorded during or immediately following the cell collection procedure. Our report describes the feasibility of performing large volume leukapheresis without complications in an extremely low-body weight patient weighing 4.5 kg using the Spectra Optia apheresis device. No catheter-related problems occurred, and apheresis was completed without any adverse event. In conclusion, we believe that very low-body weight pediatric patients need a multidisciplinary approach to manage central venous access, hemodynamic monitoring, cell collection, prevention of metabolic complications to improve safety, feasibility, and efficiency of stem cell collection procedures.

Published
2023

8. Successful “on‐demand” plerixafor for autologous peripheral blood stem‐cells transplantation for relapsed/refractory germ cell tumors

Author

Corbingi, Andrea, primary, Metafuni, Elisabetta, additional, Di Salvatore, Mariantonietta, additional, Putzulu, Rossana, additional, Chiusolo, Patrizia, additional, Schinzari, Giovanni, additional, Massini, Giuseppina, additional, Rossi, Ernesto, additional, Zini, Gina, additional, Cassano, Alessandra, additional, Sica, Simona, additional, and Piccirillo, Nicola, additional

Published
2021
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9. Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Author

Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, and Todisco, Elisabetta

Published
2023
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10. Applicability of SIE/Sies/GITMO Fitness Criteria to Therapy-Related and AML-MRC Receiving CPX-351: Results from a Large, Retrospective, Multicentric, Observational Study

Author

Palmieri, Raffaele, Guolo, Fabio, Fianchi, Luana, Ferrara, Felicetto, Martelli, Maria Paola, Rondoni, Michela, Saveria, Capria, Minetto, Paola, Minotti, Clara, Sciabolacci, Sofia, Pilo, Federica, Perrone, Salvatore, Corbingi, Andrea, Grimaldi, Francesco, De Luca, Giulia, Fili, Carla, Alati, Caterina, Mannelli, Francesco, Lessi, Federica, Marchesi, Francesco, Brunetti, Lorenzo, Capelli, Debora, Piccioni, Anna Lina, Vetro, Calogero, Mazzone, Carla, Sperotto, Alessandra, Luzi, Giovanni, Dargenio, Michelina, Mariani, Sabrina, Cerrano, Marco, Mulè, Antonino, Di Veroli, Ambra, Papayannidis, Cristina, Isidori, Alessandro, Lanza, Francesco, Gottardi, Michele, Todisco, Elisabetta, Pagano, Livio, Lemoli, Roberto Massimo, Buccisano, Francesco, and Venditti, Adriano

Published
2023
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11. Younger patients with Waldenström Macroglobulinemia exhibit low risk profile and excellent outcomes in the era of immunotherapy and targeted therapies

Author

Varettoni, Marzia, primary, Ferrari, Angela, additional, Frustaci, Anna M., additional, Ferretti, Virginia V., additional, Rizzi, Rita, additional, Motta, Marina, additional, Piazza, Francesco, additional, Merli, Michele, additional, Benevolo, Giulia, additional, Visco, Carlo, additional, Laurenti, Luca, additional, Ferrero, Simone, additional, Gentile, Massimo, additional, Del Fabro, Vittorio, additional, Abbadessa, Antonio, additional, Klersy, Catherine, additional, Musto, Pellegrino, additional, Fabbri, Nicole, additional, Deodato, Marina, additional, Dogliotti, Irene, additional, Greco, Corinna, additional, Corbingi, Andrea, additional, Luminari, Stefano, additional, and Arcaini, Luca, additional

Published
2020
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12. Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

Author

Corbingi, Andrea, primary, Innocenti, Idanna, additional, Tomasso, Annamaria, additional, Pasquale, Raffaella, additional, Visentin, Andrea, additional, Varettoni, Marzia, additional, Flospergher, Elena, additional, Autore, Francesco, additional, Morelli, Francesca, additional, Trentin, Livio, additional, Reda, Gianluigi, additional, Efremov, Dimitar G., additional, and Laurenti, Luca, additional

Published
2020
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13. Extending Long Term Follow-up of Patient With Acute Myeloid Leukemia after Autologous Stem Cell Transplantation: disclosing late mortality and causes of death.

Author

Sorà, Federica, primary, Chiusolo, Patrizia, additional, Laurenti, Luca, additional, Innocenti, Idanna, additional, Autore, Francesco, additional, Corbingi, Andrea, additional, Giammarco, Sabrina, additional, Metafuni, Elisabetta, additional, Bacigalupo, Andrea, additional, and Sica, Simona, additional

Published
2020
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14. Successful "on‐demand" plerixafor for autologous peripheral blood stem‐cells transplantation for relapsed/refractory germ cell tumors.

Author

Corbingi, Andrea, Metafuni, Elisabetta, Di Salvatore, Mariantonietta, Putzulu, Rossana, Chiusolo, Patrizia, Schinzari, Giovanni, Massini, Giuseppina, Rossi, Ernesto, Zini, Gina, Cassano, Alessandra, Sica, Simona, and Piccirillo, Nicola

Subjects
GERM cell tumors, AUTOTRANSPLANTATION, BLOOD collection, MULTIPLE myeloma, ONCOLOGY, BLOOD cells
Abstract

Background: Germ cell tumors represent, among solid cancers, a potentially curable disease even if up to 20% to 30% of patients (pts) relapse after first‐line treatment especially considering intermediate and poor prognosis groups. In this scenario, patients are candidates for high‐dose chemotherapy and autologous stem‐cells transplantation as second‐line treatment even though stem‐cells mobilization potential can be affected by several cycles and regimens of chemotherapy. To date, plerixafor is authorized in poor mobilizer adult pts diagnosed with lymphoma or multiple myeloma and in pediatric solid tumors or lymphoma. Therefore, the use of plerixafor in adult pts with relapsing/refractory GCT is still off label. Materials and methods: In our study, we describe mobilization and collection of peripheral blood stem cells for 10 pts with germ cell tumors. Six patients underwent plerixafor administration since classified as poor mobilizers based on WBC count (>5.000/μL) and CD34+ cell count (<15/μL) the day before apheresis procedure. Results: On the first day of apheresis, plerixafor administration in poor mobilizers made possible a remarkable boost of CD34+ cells in such a way to overlap that of good mobilizers' (32/μL vs 35/μL, respectively, P >.05). Conclusion: Therefore, in our experience, plerixafor made a good fraction of poor mobilizer patients eligible for mobilization and collection and able to undergo the predicted autologous stem‐cells transplantation; thus, the lack of access to the use of plerixafor in this setting of patients risks jeopardizing an effective treatment, especially in case of poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Remission of acquired von Willebrand syndrome in a patient with chronic lymphocytic leukemia treated with venetoclax

Author

Innocenti, Idanna, Morelli, Francesca, Autore, Francesco, Tomasso, Annamaria, Corbingi, Andrea, Bellesi, Silvia, Za, Tommaso, De Stefano, Valerio, Laurenti, Luca, De Stefano, Valerio (ORCID:0000-0002-5178-5827), Laurenti, Luca (ORCID:0000-0002-8327-1396), Innocenti, Idanna, Morelli, Francesca, Autore, Francesco, Tomasso, Annamaria, Corbingi, Andrea, Bellesi, Silvia, Za, Tommaso, De Stefano, Valerio, Laurenti, Luca, De Stefano, Valerio (ORCID:0000-0002-5178-5827), and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

na

Published
2019

16. Risk of infectious complications in patients with chronic lymphocytic leukemia in the era of BCR inhibitors: a retrospective single institution experience

Author

Autore, Francesco, Innocenti, Idanna, Morelli, Francesca, Sora', Federica, Corbingi, Andrea, Fianchi, Luana, Criscuolo, Marianna, Pagano, Livio, Sica, Simona, Laurenti, Luca, Sorà, Federica (ORCID:0000-0002-9607-5298), Pagano, Livio (ORCID:0000-0001-8287-928X), Sica, Simona (ORCID:0000-0003-2426-3465), Laurenti, Luca (ORCID:0000-0002-8327-1396), Autore, Francesco, Innocenti, Idanna, Morelli, Francesca, Sora', Federica, Corbingi, Andrea, Fianchi, Luana, Criscuolo, Marianna, Pagano, Livio, Sica, Simona, Laurenti, Luca, Sorà, Federica (ORCID:0000-0002-9607-5298), Pagano, Livio (ORCID:0000-0001-8287-928X), Sica, Simona (ORCID:0000-0003-2426-3465), and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

n/a

Published
2019

17. Waldenström Macroglobulinemia in Young Patients Treated in the Modern Era: A Multi-Institutional Italian Study

Author

Varettoni, Marzia, primary, Ferrari, Angela, additional, Tedeschi, Alessandra, additional, Ferretti, Virginia Valeria, additional, Rizzi, Rita, additional, Motta, Marina, additional, Piazza, Francesco, additional, Merli, Michele, additional, Benevolo, Giulia, additional, Visco, Carlo, additional, Laurenti, Luca, additional, Del Fabro, Vittorio, additional, Abbadessa, Antonio, additional, Klersy, Catherine, additional, Rattotti, Sara, additional, Deodato, Marina, additional, Greco, Corinna, additional, Corbingi, Andrea, additional, Luminari, Stefano, additional, and Arcaini, Luca, additional

Published
2019
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18. Impact of Serum Immunoglobulin Subsets and Levels on Chronic Lymphocytic Leukemia Natural History: A Retrospective Multicentric Italian Experience

Author

Laurenti, Luca, primary, Corbingi, Andrea, additional, Innocenti, Idanna, additional, Tomasso, Annamaria, additional, Pasquale, Raffaella, additional, Visentin, Andrea, additional, Varettoni, Marzia, additional, Autore, Francesco, additional, Morelli, Francesca, additional, Trentin, Livio, additional, and Reda, Gianluigi, additional

Published
2019
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20. Risk of infectious complications in patients with chronic lymphocytic leukemia in the era of BCR inhibitors: a retrospective single institution experience

Author

Autore, Francesco, primary, Innocenti, Idanna, additional, Morelli, Francesca, additional, Sorà, Federica, additional, Corbingi, Andrea, additional, Fianchi, Luana, additional, Criscuolo, Marianna, additional, Pagano, Livio, additional, Sica, Simona, additional, and Laurenti, Luca, additional

Published
2019
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23. Monoclonal Gammopathy and Hypogammaglobulinemia As Prognostic Factors in Patients with Chronic Lymphocytic Leukemia: A Retrospective Multicentric Experience

Author

Innocenti, Idanna, primary, Corbingi, Andrea, additional, Piccirillo, Nicola, additional, Autore, Francesco, additional, Visentin, Andrea, additional, Scomazzon, Edoardo, additional, Cassin, Ramona, additional, Pasquale, Raffaella, additional, Morelli, Francesca, additional, Sica, Simona, additional, Reda, Gianluigi, additional, Trentin, Livio, additional, and Laurenti, Luca, additional

Published
2018
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24. Risk of Infectious Complications in Patients with Chronic Lymphocytic Leukemia in the Era of BCR Inhibitors: A Retrospective Single Institution Experience

Author

Autore, Francesco, primary, Innocenti, Idanna, additional, Morelli, Francesca, additional, Sora, Federica, additional, Corbingi, Andrea, additional, Soldati, Denise, additional, Fianchi, Luana, additional, Criscuolo, Marianna, additional, Pagano, Livio, additional, Bacigalupo, Andrea, additional, Sica, Simona, additional, and Laurenti, Luca, additional

Published
2018
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26. Leucocytosis during induction therapy with all‐trans‐retinoic acid and arsenic trioxide in acute promyelocytic leukaemia predicts differentiation syndrome and treatment‐related complications.

Author

Cicconi, Laura, Bisegna, Marialaura, Gurnari, Carmelo, Fanciullo, David, Piciocchi, Alfonso, Marsili, Giovanni, Minotti, Clara, Scalzulli, Emilia, Mandelli, Bianca, Guarnera, Luca, Perrone, Salvatore, Ortu La Barbera, Elettra, Mecarocci, Sergio, Biagi, Annalisa, Cenfra, Natalia, Corbingi, Andrea, Scerpa, Maria Cristina, Venditti, Adriano, Martelli, Maurizio, and Voso, Maria Teresa

Subjects
*ACUTE promyelocytic leukemia, *LEUCOCYTOSIS, *PLATELET count, *BONE marrow, *PATIENTS' attitudes
Abstract

Summary All‐trans‐retinoic acid (ATRA) and arsenic trioxide (ATO) represent the standard of care for low‐intermediate risk acute promyelocytic leukaemia (APL). Leucocytosis during induction with ATRA‐ATO represents a common complication with an incidence of up to 60%. To identify predictive factors for this complication, we studied a cohort of 65 low‐intermediate risk APL patients treated with ATRA‐ATO in three highly specialized Italian centres. Overall, 39/65 (60%) patients developed leucocytosis, with a peak in leucocyte count being most frequent in the second week from diagnosis. All cases were successfully managed with hydroxyurea. Predictive factors for leucocytosis in univariate analysis were lower platelet counts (odds ratio [OR] 0.98, 0.97–1.00, p = 0.018), lower fibrinogen levels (OR 0.36, 0.17–0.66, p = 0.003), higher bone marrow blast infiltration (OR 1.03, 1.01–1.07, p = 0.021) and CD117 expression by flow (OR 1.04, 1.01–1.08, p = 0.012). Multivariate analysis confirmed lower levels of fibrinogen at diagnosis as the strongest predictive factor for the development of leucocytosis (OR 0.36, 0.15–0.72, p = 0.009). Differentiation syndrome (DS) occurred only in patients developing leucocytosis showing a strict correlation with rising leucocytes counts (16/39 vs. 0/26, p < 0.001). In addition, other treatment‐related complications including QTc prolongation, cardiac events, liver, and haematological toxicities were significantly more frequent in patients experiencing leucocytosis (22/39 vs. 3/26, p < 0.001). In conclusion, APL patients undergoing ATRA‐ATO therapy with lower fibrinogen levels and platelet counts at diagnosis and with a massive bone marrow blast infiltrate should be carefully monitored for the development of leucocytosis during induction. DS and other treatment‐related complications seem to occur almost exclusively in patients developing leucocytosis, who should necessarily receive DS prophylaxis and more intensive monitoring and supportive therapy to prevent treatment complications. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Prevention of postoperative anemia in hip hemiarthroplasty for femoral neck fractures: comparison between local haemostatic agents

Author

Antonio Ziranu, Cesare Meschini, Davide De Marco, Giuseppe Sircana, Maria Serena Oliva, Giusepp Rovere, Andrea Corbingi, Raffaele Vitiello, Giulio Maccauro, Enrico Pola, Ziranu, Antonio, Meschini, Cesare, De Marco, Davide, Sircana, Giuseppe, Oliva, Maria Serena, Rovere, Giusepp, Corbingi, Andrea, Vitiello, Raffaele, Maccauro, Giulio, and Pola, Enrico

Subjects
hip fracture, fibrin sealant, Orthopedics and Sports Medicine, General, tranexamic acid
Abstract

Background Tranexamic acid and fibrin sealant have been shown to be effective in reducing the need for transfusion after hip fracture surgery. Objective The aim of this study was to evaluate the efficacy of local haemostatic agents to reduce the need of postoperative transfusion in elederly patients after hip hemiarthroplasty. Methods All patients admitted to our institution with a diagnosis of proximal femur fracture from September 2018 to March 2021 were involved. Inclusion criteria were: diagnosis of femoral neck fracture, classified as AO 31B2-3, surgical treatment with hip hemiarthroplasty, hemoglobinemia on admission > 8 gr/dL. Patients were divided in four groups Results EVICEL was used on 25 patients, TRANEX was used on 52 patients, standard hemostatic care was used on 73 patients, while post-surgical drain was used on 21 patients. 3 patients were transfused in the EVICEL group while 26 patients were transfused in the control group (p 0,0404), there was also statistical significant difference in the need of perioperative transfusion between EVICEL group and drain group with 10 patients transfused (p 0,0102). Statistical significant differences was found about haemoglobin variation in the first post-operative day between TRANEX group and control group (p 0,000155) and between TRANEX group and drain group (p 0,013) and also between TRANEX group and control group in the third post-operative day (p 0,0004). Conclusion This study demonstrates that the use of both fibrin sealant or TXA can reduce total blood loss and the need of transfusions in geriatric population with intracapsular femur fracture.

Published
2022

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