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12 results on '"Cordeiro, Arthur Poester"'

6. Nanomedicine in leishmaniasis: A promising tool for diagnosis, treatment and prevention of disease - An update overview

Author

Assolini, João Paulo, primary, Carloto, Amanda Cristina Machado, additional, Bortoleti, Bruna Taciane da Silva, additional, Gonçalves, Manoela Daiele, additional, Tomiotto Pellissier, Fernanda, additional, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Hermes de Araújo, Pedro Henrique, additional, Sayer, Claudia, additional, Miranda Sapla, Milena Menegazzo, additional, and Pavanelli, Wander Rogério, additional

Published
2022
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7. Bovine Serum Albumin Conjugation in Superparamagnetic/Poly(methyl methacrylate) Nanoparticles as an Alternative for Magnetic Enzyme-Linked Immunosorbent Assays

Author

Feuser, Paulo Emilio, primary, Guindani, Camila, additional, Possato, Jonathann Correa, additional, Guessi, Jaqueline Pereira, additional, Cordeiro, Arthur Poester, additional, Machado-de-Ávila, Ricardo Andrez, additional, Sayer, Claudia, additional, and de Araújo, Pedro Henrique Hermes, additional

Published
2021
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8. Co-encapsulation of sodium diethyldithiocarbamate (DETC) and zinc phthalocyanine (ZnPc) in liposomes promotes increases phototoxic activity against (MDA-MB 231) human breast cancer cells

Author

Feuser, Paulo Emilio, primary, Cordeiro, Arthur Poester, additional, de Bem Silveira, Gustavo, additional, Borges Corrêa, Maria Eduarda Anastácio, additional, Lock Silveira, Paulo Cesar, additional, Sayer, Claudia, additional, de Araújo, Pedro Henrique Hermes, additional, Machado-de-Ávila, Ricardo Andrez, additional, and Dal Bó, Alexandre Gonçalves, additional

Published
2021
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9. 4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity

Author

Assolini, João Paulo, primary, da Silva, Thais Peron, additional, da Silva Bortoleti, Bruna Taciane, additional, Gonçalves, Manoela Daiele, additional, Tomiotto-Pellissier, Fernanda, additional, Sahd, Claudia Stoeglehner, additional, Carloto, Amanda Cristina Machado, additional, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Sayer, Claudia, additional, Hermes de Araújo, Pedro Henrique, additional, Costa, Idessania Nazareth, additional, Conchon-Costa, Ivete, additional, Miranda-Sapla, Milena Menegazzo, additional, and Pavanelli, Wander Rogério, additional

Published
2020
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10. Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

Author

dos Santos, Paula Christina Mattos, primary, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Scussel, Rahisa, additional, Abel, Jessica da Silva, additional, Machado-de-Ávila, Ricardo Andrez, additional, Rocha, Maria Eliane Merlin, additional, Sayer, Claudia, additional, and Hermes de Araújo, Pedro Henrique, additional

Published
2020
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11. Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage

Author

Assolini, João Paulo, primary, Tomiotto-Pellissier, Fernanda, additional, da Silva Bortoleti, Bruna Taciane, additional, Gonçalves, Manoela Daiele, additional, Sahd, Claudia Stoeglehner, additional, Carloto, Amanda Cristina Machado, additional, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Borghi, Sergio Marques, additional, Verri, Waldiceu Aparecido, additional, Sayer, Claudia, additional, Hermes de Araújo, Pedro Henrique, additional, Costa, Idessania Nazareth, additional, Conchon-Costa, Ivete, additional, Miranda-Sapla, Milena Menegazzo, additional, and Pavanelli, Wander Rogério, additional

Published
2020
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12. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562)

Author

Feuser, Paulo Emílio, Matos dos Santos, Paula Christina, Cordeiro, Arthur Poester, Stefanes, Natália Marceli, Walter, Laura Otto, Maioral, Mariana Franzoni, Santos-Silva, Maria Cláudia, Hermes Araújo, Pedro Henrique, and Sayer, Claudia

Abstract

Poly(thioether-ester) (PTEe), a polymer synthesized from renewable monomers, is a promising alternative for the encapsulation of antitumor drugs due to its biocompatibility and biodegradability. Therefore, the aim of this study was to synthesize, characterize and evaluate the cytotoxicity of free 4-nitrochalcone (4NC) and 4NC encapsulated in PTEe nanoparticles prepared by thiol-ene miniemulsion polymerization in chronic myeloid leukemia in blast crisis (K562) and acute lymphoblastic leukemia (Jurkat) and peripheral blood mononuclear cells. 4NC was successfully encapsulated in PTEe nanoparticles with an encapsulation efficiency >90%, a mean size of 110 nm, negative surface charge and extended-release profile. Free 4NC and encapsulated in PTEe nanoparticles presented a significant cytotoxicity on K562 and Jurkat cells. Also, 4NC encapsulated in PTEe nanoparticles presented lower damage to peripheral blood mononuclear cells, providing a higher selectivity index than free 4NC for chronic myeloid leukemia in blast crisis (K562) and acute lymphoblastic leukemia (Jurkat). Considering the difficulties involved in leukemia treatment and good results obtained with free 4NC and encapsulated in PTEe nanoparticles, these results can be a new tool for the treatment of neoplastic cells.

Published
2021
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