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12. Reference Interval for Serum L-Homoarginine Determined with Enzyme-Linked Immunosorbent Assay in the Population-Based Study of Health in Pomerania .

Author

Schwedhelm, Edzard, Cordts, Kathrin, Moritz, Eileen, Wesemann, Reinhard, Choe, Chi-un, Böger, Rainer, Ittermann, Till, Dörr, Marcus, Friedrich, Nele, and Bahls, Martin

Subjects
ENZYME-linked immunosorbent assay, ISOMERS, CHRONIC kidney failure, BODY mass index, LIVER enzymes, CARDIOVASCULAR diseases risk factors
Abstract

Background: Low levels of the endogenous amino acid L-homoarginine are a risk factor for cardiovascular morbidity and mortality. For individual risk prediction, commercially available test systems are mandatory. This study aims at formulating sex- and age-specific reference intervals of serum L-homoarginine determined with an ELISA. Methods: We determined reference intervals for serum L-homoarginine stratified by age and sex in a sample of 1285 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of participants with cardiovascular diseases, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stages III or IV, or body mass index >25 kg/m2. Serum L-homoarginine was determined applying a commercially available ELISA. Results: The reference cohort included 836 women (median age 41, 25th and 75th percentiles are 32 and 50 years) and 449 men (median age 38, 25th, and 75th percentiles are 30 and 49 years). The median serum concentration of L-homoarginine was 1.93 (25th 1.49; 75th 2.60) µmol/L in women and 2.02 (25th 1.63; 75th 2.61) µmol/L in men (P = 0.04). The reference intervals (2.5th to 97.5th percentile) were 0.89–5.29 µmol/L for women and 1.09–3.76 µmol/L for men. The L-homoarginine serum concentration declined over age decades in both sexes and a notable interaction with sex hormone intake in women was observed. Conclusions: The novelty of our study is that we determined reference intervals specific for the L-isomer being lower than those previously reported for homoarginine in SHIP and thus might be helpful in identifying individuals suitable for oral L-homoarginine supplementation. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure

Author

Sasani, Ali, primary, Hornig, Sönke, additional, Grzybowski, Ricarda, additional, Cordts, Kathrin, additional, Hanff, Erik, additional, Tsikas, Dimitris, additional, Böger, Rainer, additional, Gerloff, Christian, additional, Isbrandt, Dirk, additional, Neu, Axel, additional, Schwedhelm, Edzard, additional, and Choe, Chi-un, additional

Published
2019
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20. Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction

Author

Baldassarri, Flavia, primary, Schwedhelm, Edzard, additional, Atzler, Dorothee, additional, Böger, Rainer H., additional, Cordts, Kathrin, additional, Haller, Bernhard, additional, Pressler, Axel, additional, Müller, Stephan, additional, Suchy, Christiane, additional, Wachter, Rolf, additional, Düngen, Hans-Dirk, additional, Hasenfuss, Gerd, additional, Pieske, Burkert, additional, Halle, Martin, additional, Edelmann, Frank, additional, and Duvinage, André, additional

Published
2018
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21. Oral supplementation with L‐homoarginine in young volunteers

Author

Atzler, Dorothee, Schönhoff, Mirjam, Cordts, Kathrin, Ortland, Imke, Hoppe, Julia, Hummel, Friedhelm C., Gerloff, Christian, Jaehde, Ulrich, Jagodzinski, Annika, Böger, Rainer H., Choe, Chi‐un, and Schwedhelm, Edzard

Subjects
Adult, Male, Cross-Over Studies, Dose-Response Relationship, Drug, Administration, Oral, Cardiovascular System, Homoarginine, Drug Administration Schedule, Healthy Volunteers, Young Adult, Double-Blind Method, Area Under Curve, Dietary Supplements, Humans, Clinical Trials, Female, Endothelium, Vascular
Abstract

Low blood concentrations of the naturally occurring amino acid L-homoarginine (L-hArg) are related to impaired cardiovascular outcome and mortality in humans and animals. L-hArg is a weak substrate of nitric oxide synthase and an inhibitor of arginases in vitro. The aim of our study was to obtain kinetic and dynamic data after oral L-hArg supplementation.In a double-blind, randomized, placebo-controlled crossover study, 20 young volunteers received 125 mg L-hArg once daily for 4 weeks. Kinetic parameters (COne hour after ingestion (TOnce daily orally applied 125 mg L-hArg raises plasma L-hArg four- and sevenfold after single dose and 4 weeks of supplementation, respectively, and is safe and well tolerated in young volunteers.

Published
2016

22. Low homoarginine levels in the prognosis of patients with acute chest pain

Author

Atzler, Dorothee, Baum, Christina, Ojeda, Francisco, Keller, Till, Cordts, Kathrin, Schnabel, Renate B., Choe, Chi‐un, Lackner, Karl Johannes, Münzel, Thomas, Böger, Rainer H., Blankenberg, Stefan, Schwedhelm, Edzard, Zeller, Tanja, Atzler, Dorothee, Baum, Christina, Ojeda, Francisco, Keller, Till, Cordts, Kathrin, Schnabel, Renate B., Choe, Chi‐un, Lackner, Karl Johannes, Münzel, Thomas, Böger, Rainer H., Blankenberg, Stefan, Schwedhelm, Edzard, and Zeller, Tanja

Abstract

Background The endogenous amino acid homoarginine predicts mortality in cerebro‐ and cardiovascular disease. The objective was to explore whether homoarginine is associated with atrial fibrillation (AF) and outcome in patients with acute chest pain. Methods and Results One thousand six hundred forty‐nine patients with acute chest pain were consecutively enrolled in this study, of whom 589 were diagnosed acute coronary syndrome (ACS). On admission, plasma concentrations of homoarginine as well as brain natriuretic peptide (BNP), and high‐sensitivity assayed troponin I (hsTnI) were determined along with electrocardiography (ECG) variables. During a median follow‐up of 183 days, 60 major adverse cardiovascular events (MACEs; 3.8%), including all‐cause death, myocardial infarction, or stroke, were registered in the overall study population and 43 MACEs (7.5%) in the ACS subgroup. Adjusted multivariable Cox regression analyses revealed that an increase of 1 SD of plasma log‐transformed homoarginine (0.37) was associated with a hazard reduction of 26% (hazard ratio [HR], 0.74; 95% CI, 0.57–0.96) for incident MACE and likewise of 35% (HR, 0.65; 95% CI, 0.49–0.88) in ACS patients. In Kaplan–Meier survival curves, homoarginine was predictive for patients with high‐sensitivity assayed troponin I (hsTnI) above 27 ng/L (P<0.05). Last, homoarginine was inversely associated with QTc duration (P<0.001) and prevalent AF (OR, 0.83; 95% CI, 0.71–0.95). Conclusion Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.

Published
2016

24. Oral supplementation with L-homoarginine in young volunteers

Author

Atzler, Dorothee, primary, Schönhoff, Mirjam, additional, Cordts, Kathrin, additional, Ortland, Imke, additional, Hoppe, Julia, additional, Hummel, Friedhelm C., additional, Gerloff, Christian, additional, Jaehde, Ulrich, additional, Jagodzinski, Annika, additional, Böger, Rainer H., additional, Choe, Chi-un, additional, and Schwedhelm, Edzard, additional

Published
2016
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25. Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain

Author

Atzler, Dorothee, primary, Baum, Christina, additional, Ojeda, Francisco, additional, Keller, Till, additional, Cordts, Kathrin, additional, Schnabel, Renate B., additional, Choe, Chi‐un, additional, Lackner, Karl J., additional, Münzel, Thomas, additional, Böger, Rainer H., additional, Blankenberg, Stefan, additional, Schwedhelm, Edzard, additional, and Zeller, Tanja, additional

Published
2016
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26. Reference intervals of plasma homoarginine from the German Gutenberg Health Study

Author

Atzler, Dorothee, primary, Appelbaum, Sebastian, additional, Cordts, Kathrin, additional, Ojeda, Francisco M., additional, Wild, Philipp S., additional, Münzel, Thomas, additional, Blankenberg, Stefan, additional, Böger, Rainer H., additional, Blettner, Maria, additional, Beutel, Manfred E., additional, Pfeiffer, Norbert, additional, Zeller, Tanja, additional, Lackner, Karl J., additional, and Schwedhelm, Edzard, additional

Published
2015
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28. Oral supplementation with L-homoarginine in young volunteers

Author

Atzler, Dorothee, Schönhoff, Mirjam, Cordts, Kathrin, Ortland, Imke, Hoppe, Julia, Hummel, Friedhelm C, Gerloff, Christian, Jaehde, Ulrich, Jagodzinski, Annika, Böger, Rainer H, Choe, Chi-Un, and Schwedhelm, Edzard

Abstract

Low blood concentrations of the naturally occurring amino acid L-homoarginine (L-hArg) are related to impaired cardiovascular outcome and mortality in humans and animals. L-hArg is a weak substrate of nitric oxide synthase and an inhibitor of arginases in vitro. The aim of our study was to obtain kinetic and dynamic data after oral L-hArg supplementation.

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