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3. Western Diet Modifies Platelet Activation Profiles in Male Mice.

Author

Corken, Adam, Wahl, Elizabeth C., Sikes, James D., and Thakali, Keshari M.

Subjects
*WESTERN diet, *REDUCING diets, *BLOOD platelet activation, *CARDIOVASCULAR diseases, *FLOW cytometry
Abstract

The correlation between obesity and cardiovascular disease has long been understood, yet scant investigations endeavored to determine the impact of an obesogenic diet on platelet activation or function. As platelets drive clot formation, the terminus of cardiovascular events, we aimed to elucidate the longitudinal effect of an obesogenic diet on platelet phenotype by assessing markers of platelet activation using flow cytometry. Male, weanling mice were fed either a Western diet (30% kcal sucrose, 40% kcal fat, 8.0% sodium) or Control diet (7% kcal sucrose, 10% kcal fat, 0.24% sodium). At 12, 16 and 20 weeks on diets, platelets were collected and stained to visualize glycoprotein Ibα (GPIbα), P-selectin and the conformationally active state of αIIbβ3 (a platelet specific integrin) after collagen stimulation. At all time points, a Western diet reduced GPIbα and αIIbβ3 expression in platelets broadly while P-selectin levels were unaffected. However, P-selectin was diminished by a Western diet in the GPIbα− subpopulation. Thus, a Western diet persistently primed platelets towards a blunted activation response as indicated by reduced active αIIbβ3 and P-selectin surface expression. This study provides a first look at the influence of diet on platelet activation and revealed that platelet activation is susceptible to dietary intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study

Author

Corken, Adam, primary, Ware, Jerry, additional, Dai, Junqiang, additional, Arthur, John M., additional, Smyth, Susan, additional, Davis, Clayton L., additional, Liu, Juan, additional, Harville, Terry O., additional, Phadnis, Milind A., additional, Mehta, Jawahar L., additional, Rahmatallah, Yasir, additional, and Jain, Nishank, additional

Published
2022
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15. The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma

Author

Stein, Caleb K., primary, Pawlyn, Charlotte, additional, Chavan, Shweta, additional, Rasche, Leo, additional, Weinhold, Niels, additional, Corken, Adam, additional, Buros, Amy, additional, Sonneveld, Pieter, additional, Jackson, Graham H., additional, Landgren, Ola, additional, Mughal, Tariq, additional, He, Jie, additional, Barlogie, Bart, additional, Bergsagel, P. Leif, additional, Davies, Faith E., additional, Walker, Brian A., additional, and Morgan, Gareth J., additional

Published
2017
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20. Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality

Author

Yin, Hong, primary, Stojanovic-Terpo, Aleksandra, additional, Xu, Weidong, additional, Corken, Adam, additional, Zakharov, Alexander, additional, Qian, Feng, additional, Pavlovic, Sasha, additional, Krbanjevic, Aleksandar, additional, Lyubimov, Alexander V., additional, Wang, Zaijie J., additional, Ware, Jerry, additional, and Du, Xiaoping, additional

Published
2013
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