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1. Point-of-care HPV DNA testing of self-collected specimens and same-day thermal ablation for the early detection and treatment of cervical pre-cancer in women in Papua New Guinea: a prospective, single-arm intervention trial (HPV-STAT)

Author

Vallely, Andrew J B, Saville, Marion, Badman, Steven G, Gabuzzi, Josephine, Bolnga, John, Mola, Glen D L, Kuk, Joseph, Wai, Malts, Munnull, Gloria, Garland, Suzanne M, Brotherton, Julia M L, Kelly-Hanku, Angela, Morgan, Christopher, Toliman, Pamela J, Kombati, Zure, Kariwiga, Grace, Babona, Delly, Tan, Grace, Simms, Kate T, Cornall, Alyssa M, Tabrizi, Sepehr N, Wand, Handan, Guy, Rebecca, Canfell, Karen, and Kaldor, John M

Published
2022
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10. Performance of Human Papillomavirus Attribution Algorithms to Predict Causative Genotypes in Anal High-Grade Lesions

Author

Phillips, Samuel, primary, Cornall, Alyssa M, additional, Molano, Monica, additional, Jin, Fengyi, additional, Roberts, Jennifer M, additional, Farnsworth, Annabelle, additional, Hillman, Richard J, additional, Templeton, David J, additional, Poynten, I Mary, additional, Garland, Suzanne M, additional, Fairley, Christopher K, additional, Murray, Gerald L, additional, Tabrizi, Sepehr N, additional, Grulich, Andrew E, additional, and Machalek, Dorothy A, additional

Published
2023
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16. Cover Image

Author

Belobrov, Simone, Cornall, Alyssa M., Young, Richard J., Koo, Kendrick, Angel, Christopher, Wiesenfeld, David, Rischin, Danny, Garland, Suzanne M., and McCullough, Michael

Published
2018
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24. Human papillomavirus prevalence and risk factors among Australian women 9–12 years after vaccine program introduction

Author

Shilling, Hannah, primary, Garland, Suzanne M., additional, Atchison, Steph, additional, Cornall, Alyssa M., additional, Brotherton, Julia M.L., additional, Bateson, Deborah, additional, McNamee, Kathleen, additional, Kaldor, John M., additional, Hocking, Jane S., additional, Chen, Marcus Y., additional, Fairley, Christopher K., additional, McNulty, Anna, additional, Bell, Charlotte, additional, Marshall, Lewis, additional, Ooi, Catriona, additional, Skinner, S. Rachel, additional, Murray, Gerald, additional, Molano, Monica, additional, Tabrizi, Sepehr, additional, and Machalek, Dorothy A., additional

Published
2021
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26. Human Papillomavirus Antibody Levels Following Vaccination or Natural Infection Among Young Men Who Have Sex With Men.

Author

Chow, Eric P F, Fairley, Christopher K, Zou, Huachun, Wigan, Rebecca, Garland, Suzanne M, Cornall, Alyssa M, Atchison, Steph, Tabrizi, Sepehr N, and Chen, Marcus Y

Subjects
PAPILLOMAVIRUSES, IMMUNIZATION, MANN Whitney U Test, IMMUNOASSAY, HUMAN papillomavirus vaccines, GENOTYPES, DESCRIPTIVE statistics, VIRAL antibodies, MEN who have sex with men, EPIDEMIOLOGICAL research
Abstract

Background Australia introduced a school-based gender-neutral human papillomavirus (HPV) vaccination program for girls and boys aged 12–13 years in 2013. We examined HPV type–specific antibody levels in unvaccinated young men who have sex with men (MSM) with natural infection and compared these with levels in those vaccinated against HPV. Methods Serum specimens at baseline were collected from MSM aged 16–20 years in the HYPER1 (Human Papillomavirus in Young People Epidemiological Research) and HYPER2 studies, conducted in 2010–2013 and 2017–2019, respectively. Merck's 4-plex HPV competitive Luminex Immunoassay was used to quantify HPV6-, HPV11-, HPV16-, and HPV18-specific antibodies. We compared antibody levels for each HPV genotype between unvaccinated men (HYPER1) and vaccinated men (HYPER2) using the Mann-Whitney U test. Results There were 200 unvaccinated men and 127 vaccinated men included in the analysis. Median antibody levels among vaccinated men were significantly higher than levels among unvaccinated men for HPV6 (223 milli-Merck units per milliliter [mMU/mL] vs 48 mMU/mL, P  < .0001), HPV11 (163 mMU/mL vs 21 mMU/mL, P  < .0001), HPV16 (888 mMU/mL vs 72 mMU/mL, P  < .0001), and HPV18 (161 mMU/mL vs 20 mMU/mL, P  < .0001). Antibody levels did not change over time for up to 66 months for all 4 genotypes among vaccinated men. Conclusions Among young MSM vaccinated with the quadrivalent HPV vaccine, antibody levels for HPV6, HPV11, HPV16, and HPV18 were significantly higher than those in unvaccinated MSM following natural infection. Antibody levels following vaccination appeared to remain stable over time. Clinical Trials Registration NCT01422356 for HYPER1 and NCT03000933 for HYPER2. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Human Papillomavirus Genotypes in Anal High-Grade Squamous Intraepithelial Lesion (HSIL): Anal Intraepithelial Neoplasia Grades 2 (AIN2) and 3 (AIN3) Are Different

Author

Roberts, Jennifer M., primary, Poynten, Isobel M., additional, Molano, Monica, additional, Machalek, Dorothy A., additional, Hillman, Richard J., additional, Guzman, Patricia, additional, Jin, Fengyi, additional, Templeton, David J., additional, Fairley, Christopher K., additional, Law, Carmella, additional, Garland, Suzanne M., additional, Grulich, Andrew E., additional, and Cornall, Alyssa M., additional

Published
2020
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29. Assessment of attribution algorithms for resolving CIN3-related HPV genotype prevalence in mixed-genotype biopsy specimens using laser capture microdissection as the reference standard

Author

Cornall, Alyssa M., primary, Brotherton, Julia M.L., additional, Callegari, Emma T., additional, Tan, Fiona H., additional, Saville, Marion, additional, Pyman, Jan, additional, Phillips, Samuel, additional, Malloy, Michael J., additional, Tabrizi, Sepehr N., additional, and Garland, Suzanne M., additional

Published
2020
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31. The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men

Author

Poynten, I Mary, primary, Jin, Fengyi, additional, Roberts, Jennifer M, additional, Templeton, David J, additional, Law, Carmella, additional, Cornall, Alyssa M, additional, Molano, Monica, additional, Machalek, Dorothy A, additional, Carr, Andrew, additional, Farnsworth, Annabelle, additional, Tabrizi, Sepehr, additional, Phillips, Samuel, additional, Fairley, Christopher K, additional, Garland, Suzanne M, additional, Hillman, Richard J, additional, and Grulich, Andrew E, additional

Published
2020
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32. Prevalence of anal cytological abnormalities and high‐risk human papillomavirus prevalence in kidney transplant recipients: A cross‐sectional study.

Author

Rosales, Brenda M., Langton‐Lockton, Julian, Hedley, James, Cornall, Alyssa M., Roberts, Jennifer M., Garland, Suzanne M., Kelly, Patrick J., Hillman, Richard J., and Webster, Angela C.

Subjects
KIDNEY transplantation, HUMAN abnormalities, SEXUALLY transmitted diseases, ANAL cancer, SQUAMOUS cell carcinoma
Abstract

Background: Transplant recipients are at high‐risk of anal squamous cell cancer. We aimed to estimate the prevalence of high‐risk human papillomavirus (HPV) and high‐grade squamous intraepithelial lesion (HSIL) and assess characteristics associated with results Methods: We recruited kidney transplant recipients in a single‐center, 2015–2018. Participants completed a clinical questionnaire and received an anal‐swab sent for HPV‐DNA and cytological testing Results: A total of 97 (74%) of 125 recipients approached consented to participate. Participants were median 47 (IQR 40–55) years, 60% male and median 4.5 (IQR.9‐13) months‐since‐transplant. Of 86 assessable samples, at least one HPV genotype was detected in 15 (17%) participants; 1 (1%) HPV16, 8 (9%) other high‐risk HPV. Of 76 assessable cytology samples, 9 (12%) showed evidence of abnormality; 1 (1%) HSIL, 1 (1%) atypical‐squamous‐cells, cannot exclude HSIL. Both HSIL recipients had high‐risk HPV and biopsy confirmed HSIL. High‐risk HPV was detected in six (9%) recipients with normal cytology. History of sexually transmitted infection, and abnormal cervical pap smear in women, was associated with high‐risk HPV and HSIL Conclusions: High‐risk HPV and HSIL testing may identify kidney transplant recipients at higher risk of anal cancer. Longitudinal studies are needed to describe the natural history of anal cancer in transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia: 2014–2017

Author

Chow, Eric P.F., primary, Tabrizi, Sepehr N., additional, Fairley, Christopher K., additional, Wigan, Rebecca, additional, Machalek, Dorothy A., additional, Regan, David G., additional, Hocking, Jane S., additional, Garland, Suzanne M., additional, Cornall, Alyssa M., additional, Atchison, Steph, additional, Bradshaw, Catriona S., additional, McNulty, Anna, additional, Owen, Louise, additional, Marshall, Lewis, additional, Russell, Darren B., additional, Kaldor, John M., additional, and Chen, Marcus Y., additional

Published
2019
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34. The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men.

Author

Poynten, I Mary, Jin, Fengyi, Roberts, Jennifer M, Templeton, David J, Law, Carmella, Cornall, Alyssa M, Molano, Monica, Machalek, Dorothy A, Carr, Andrew, Farnsworth, Annabelle, Tabrizi, Sepehr, Phillips, Samuel, Fairley, Christopher K, Garland, Suzanne M, Hillman, Richard J, and Grulich, Andrew E

Subjects
DISEASE progression, ANUS, CONFIDENCE intervals, MEN'S health, CERVICAL intraepithelial neoplasia, EARLY detection of cancer, DISEASE incidence, ANAL tumors, DESCRIPTIVE statistics, CYTOLOGY, GAY men, PROPORTIONAL hazards models, DISEASE risk factors
Abstract

Background Gay and bisexual men (GBM) are disproportionately affected by anal cancer. Prevention is hindered by incomplete understanding of the natural history of its precursor, anal high-grade squamous intraepithelial lesions (HSIL). Methods The Study of the Prevention of Anal Cancer, conducted between 2010 and 2018, enrolled human immunodeficiency virus (HIV)-positive and HIV-negative GBM aged ≥35 years. Anal cytology and high-resolution anoscopy (HRA) were performed at baseline and 3 annual visits. A composite HSIL diagnosis (cytology ± histology) was used. Cytological high-grade squamous intraepithelial lesions (cHSIL) incidence and clearance rates were calculated with 95% confidence intervals (CIs). Predictors were calculated using Cox regression with hazard ratios (HRs) and 95% CIs. Results Among 617 men, 220 (35.7%) were HIV-positive, median age 49 years. And 124 incident cHSIL cases occurred over 1097.3 person-years (PY) follow-up (11.3, 95% CI 9.5–13.5 per 100 PY). Significant bivariate predictors of higher incidence included age <45 years (HR 1.64, 95% CI 1.11–2.41), HIV positivity (HR 1.43, 95% CI.99–2.06), prior SIL diagnosis (P -trend <.001) and human papillomavirus (HPV)16 (HR 3.39, 2.38–4.84). Over 695.3 PY follow-up, 153 HSIL cleared (clearance 22.0, 95% CI 18.8–25.8 per 100 PY). Predictors were age < 45 years (HR 1.52, 1.08–2.16), anal intraepithelial neoplasia (AIN)2 rather than AIN3 (HR 1.79, 1.29–2.49), smaller lesions (HR 1.62, 1.11–2.36) and no persistent HPV16 (HR 1.72, 1.23–2.41). There was 1 progression to cancer (incidence 0.224, 95% CI.006–1.25 per 100 PY). Conclusion These data strongly suggest that not all anal HSIL detected in screening requires treatment. Men with persistent HPV16 were less likely to clear HSIL and are more likely to benefit from effective HSIL treatments. Clinical Trials Registration Australia New Zealand Clinical Trials Registry (ANZCTR365383). [ABSTRACT FROM AUTHOR]

Published
2021
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35. Correlation between HPV16 positivity on anal swab and biopsy-confirmed HSIL caused by HPV16 in the study of the prevention of anal cancer (SPANC)

Author

Roberts, Jennifer M., primary, Molano, Monica, additional, Thurloe, Julia K., additional, Hillman, Richard J., additional, Templeton, David J., additional, Law, Carmella, additional, Mary Poynten, I., additional, Jin, Fengyi, additional, Guzman, Patricia, additional, Garland, Suzanne M., additional, Machalek, Dorothy A., additional, Grulich, Andrew E., additional, and Cornall, Alyssa M., additional

Published
2018
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36. Laser capture microdissection-identified HPV genotypes associated with intra-anal high and low-grade intraepithelial lesions

Author

Roberts, Jennifer M., primary, Molano, Monica, additional, Thurloe, Julia K., additional, Hillman, Richard J., additional, Templeton, David J., additional, Law, Carmella, additional, Mary Poynten, I., additional, Jin, Fengyi, additional, Guzman, Patricia, additional, Garland, Suzanne M., additional, Machalek, Dorothy A., additional, Grulich, Andrew E., additional, and Cornall, Alyssa M., additional

Published
2018
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39. The role of human papillomavirus in p16-positive oral cancers

Author

Belobrov, Simone, primary, Cornall, Alyssa M., additional, Young, Richard J., additional, Koo, Kendrick, additional, Angel, Christopher, additional, Wiesenfeld, David, additional, Rischin, Danny, additional, Garland, Suzanne M., additional, and McCullough, Michael, additional

Published
2017
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42. Transplant Recipients and Anal Neoplasia Study: Design, Methods, and Participant Characteristics of a Prevalence Study

Author

Rosales, Brenda Maria, Langton-Lockton, Julian, Cornall, Alyssa M., Roberts, Jennifer M., Hillman, Richard J., and Webster, Angela Claire

Abstract

Kidney recipients have anal cancer rates 3 times higher than the general population in Australia and New Zealand. High-risk human papillomavirus (HPV) genotypes are implicated in the majority of anal cancers. Establishing the epidemiology of anal HPV infection and precursors of anal cancer in transplant recipient populations is 1 consideration in any potential screening program. The Transplant and Anal Neoplasia Study is a cross-sectional study of the prevalence of anal cytological abnormalities and HPV deoxyribonucleic acid in kidney transplant recipients, as well as evaluating the acceptability of an anal cancer screening intervention. The study aims to recruit 100 kidney transplant recipients, older than 18 years, in Australia. Transplant recipients attending for a protocol biopsy at 3 and 12 months and annually posttransplant are approached to participate. Participants undergo an anal swab, which is then analyzed using liquid-based cytological examination and tested for the detection of 37 anogenital HPV deoxyribonucleic acid genotypes. Participants also complete a demographic and behavioral questionnaire that covers sexual behavior, history of anal symptoms, and possible anal cancer risk factors. Associations will be tested using multiple regression analysis. Recruitment for the study began in 2015 and is ongoing. To date, 96 (77%) of 125 kidney transplant recipients approached have consented to the study. The mean age is 48 (median, 47 y; range, 20–76 y), 59% are male, and Northwest European (58%) represented the largest ethnic group. No participants self-identified as Aboriginal or Torres Strait Islander. High consent rates and positive qualitative results suggest that a larger screening program may be well received by kidney transplant recipients, with increased resources and some modification to the timing of approach. Further results of the study will inform the possible implementation of a larger screening trial for prevention of anal cancers in kidney and other solid organ transplant recipients.

Published
2024
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43. Human papillomavirus prevalence in unvaccinated heterosexual males following a national female vaccination program

Author

Machalek, Dorothy A., primary, Chow, Eric P.F., additional, Garland, Suzanne M., additional, Wigan, Rebecca, additional, Cornall, Alyssa M., additional, Fairley, Christopher K., additional, Kaldor, John M., additional, Hocking, Jane S., additional, Williams, Henrietta, additional, McNulty, Anna, additional, Bell, Charlotte, additional, Marshall, Lewis, additional, Ooi, Catriona, additional, Chen, Marcus Y., additional, and Tabrizi, Sepehr N., additional

Published
2016
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44. Papillary Immature Metaplasia of the Anal Canal

Author

Roberts, Jennifer M., primary, Cornall, Alyssa M., additional, Ekman, Deborah, additional, Law, Carmella, additional, Poynten, I. Mary, additional, Jin, Fengyi, additional, Hillman, Richard J., additional, Templeton, David J., additional, Tabrizi, Sepehr N., additional, Garland, Suzanne M., additional, Thurloe, Julia K., additional, Grulich, Andrew E., additional, and Farnsworth, Annabelle, additional

Published
2016
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45. Molecular screening of microbial communities for candidate indicators of multiple metal impacts in marine sediments from northern Australia

Author

Cornall, Alyssa M., Rose, Alea M., Streten-Joyce, Claire, McGuinness, Keith A., Parry, David L., Gibb, Karen S., Cornall, Alyssa M., Rose, Alea M., Streten-Joyce, Claire, McGuinness, Keith A., Parry, David L., and Gibb, Karen S.

Abstract

Coastal sediments accumulate metals from anthropogenic sources and as a consequence industry is required to monitor sediment health. The total concentration of a metal does not necessarily reflect its potential toxicity or biological impact, so biological assessment tools are useful for monitoring. Rapid biological assessment tools sensitive enough to detect relatively small increases in metal concentrations would provide early warning of future ecosystem impact. The authors investigated in situ populations of Archaea and Bacteria as potential tools for rapid biological assessment in sediment at 4 northern Australian coastal locations over 2 yr, in both wet and dry seasons. The 1 M HCl-extractable concentrations of metals in sediment were measured, and Archaeal and Bacterial community profiles were obtained by next-generation sequencing of sediment deoxyribonucleic acid (DNA). Species response curves were used to identify several taxonomic groups with potential as biological indicators of metal impact. Spatial variation, sediment grain size, water depth, and dissolved oxygen also correlated with microbial population shifts. Seasonal variation was less important than geographic location. Metal-challenge culture trials supported the identification of metal-resistant and -sensitive taxa. In situ Archaea and Bacteria are potentially sensitive indicators for changes in bioavailable concentrations of metals; however, the complexity of the system suggests it is important to identify metal-specific functional genes that may be informed by these sequencing surveys, and thus provide a useful addition to identity-based assays.

Published
2015

46. Laser capture microdissection as a tool to evaluate human papillomavirus genotyping and methylation as biomarkers of persistence and progression of anal lesions

Author

Cornall, Alyssa M, primary, Roberts, Jennifer M, additional, Molano, Monica, additional, Machalek, Dorothy A, additional, Phillips, Samuel, additional, Hillman, Richard J, additional, Grulich, Andrew E, additional, Jin, Fengyi, additional, Poynten, I Mary, additional, Templeton, David J, additional, Garland, Suzanne M, additional, and Tabrizi, Sepehr N, additional

Published
2015
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48. Site-specific human papillomavirus infection in adolescent men who have sex with men (HYPER): an observational cohort study

Author

Zou, Huachun, primary, Tabrizi, Sepehr N, additional, Grulich, Andrew E, additional, Hocking, Jane S, additional, Bradshaw, Catriona S, additional, Cornall, Alyssa M, additional, Morrow, Andrea, additional, Prestage, Garrett, additional, Law, Matthew G, additional, Garland, Suzanne M, additional, Chen, Marcus Y, additional, and Fairley, Christopher K, additional

Published
2015
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49. Genetic and Environmental Factors in Invasive Cervical Cancer: Design and Methods of a Classical Twin Study.

Author

Machalek, Dorothy A., Wark, John D., Tabrizi, Sepehr N., Hopper, John L., Bui, Minh, Dite, Gillian S., Cornall, Alyssa M., Pitts, Marian, Gertig, Dorota, Erbas, Bircan, and Garland, Suzanne M.

Subjects
CERVICAL cancer, CANCER invasiveness, PAPILLOMAVIRUS diseases, CERVICAL intraepithelial neoplasia, HUMAN sexuality, GENETICS, DISEASE risk factors, CERVIX uteri diseases, DYSPLASIA, PAPILLOMAVIRUSES, TWINS, CERVIX uteri tumors, PHENOTYPES, SYMPTOMS
Abstract

Background: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical cancer and its precursor lesion, high-grade squamous intraepithelial lesion (HSIL). However, HPV infection is not sufficient to drive this process, and genetic and environmental factors may also play a role.Methods/design: The Cervical Cancer, Genetics and Environment Twin Study was established to investigate the environmental and genetic influences on variation in susceptibility to cervical pre-cancer in 25- to 69-year-old monozygotic (MZ) and dizygotic (DZ) twins recruited through the Australian Twin Registry. Reviews of Papanicolaou (Pap) screening histories were undertaken to identify individual women with a history of an abnormal Pap test. This was followed by detection of HPV in archival Pap smears of selected twin pairs to determine HPV persistence. Selected twin pairs also completed a detailed questionnaire on socio-demographic characteristics, sexual behavior, and HPV knowledge. In future analyses, under the assumptions of the classical twin design, case-wise concordance for persistent HPV infection and HSIL will be calculated for MZ and DZ twin pairs, and twin pairs (both MZ and DZ) who are discordant for the above outcomes will be used to assess the contributions of measured environmental risk factors.Discussion: The study examines factors related to HPV persistence and development of HSIL among female MZ and DZ twins. The results will contribute to our understanding of the natural history of cervical HPV infection and the relative contributions of genetic and environmental factors in disease progression. [ABSTRACT FROM AUTHOR]

Published
2017
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