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2. UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

Author

Shi, Xinrui, primary, Facemire, Loryn, additional, Singh, Sandeep, additional, Kumar, Shailesh, additional, Cornelison, Robert, additional, Liang, Chen, additional, Qin, Fujun, additional, Liu, Aiqun, additional, Lin, Shitong, additional, Tang, Yue, additional, Elfman, Justin, additional, Manley, Thomas, additional, Bullock, Timothy, additional, Haverstick, Doris M., additional, Wu, Peng, additional, and Li, Hui, additional

Published
2024
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3. Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Author

Elagib, Kamaleldin E., Brock, Ashton, Clementelli, Cara M., Mosoyan, Goar, Delehanty, Lorrie L., Sahu, Ranjit K., Pacheco-Benichou, Alexandra, Fruit, Corinne, Besson, Thierry, Morris, Stephan W., Eto, Koji, Jobaliya, Chintan, French, Deborah L., Gadue, Paul, Singh, Sandeep, Shi, Xinrui, Qin, Fujun, Cornelison, Robert, Li, Hui, Iancu-Rubin, Camelia, and Goldfarb, Adam N.

Subjects
Bone marrow cells -- Analysis, Morphogenesis -- Health aspects, Hematopoietic stem cells -- Transplantation, Infants (Newborn) -- Health aspects, Thrombocytopenia -- Risk factors -- Prevention, Health care industry
Abstract

Infantile (fetal and neonatal) megakaryocytes (Mks) have a distinct phenotype consisting of hyperproliferation, limited morphogenesis, and low platelet production capacity. These properties contribute to clinical problems that include thrombocytopenia in neonates, delayed platelet engraftment in recipients of cord blood stem cell transplants, and inefficient ex vivo platelet production from pluripotent stem cell-derived Mks. The infantile phenotype results from deficiency of the actin-regulated coactivator, MKL1, which programs cytoskeletal changes driving morphogenesis. As a strategy to complement this molecular defect, we screened pathways with the potential to affect MKL1 function and found that DYRK1A inhibition dramatically enhanced Mk morphogenesis in vitro and in vivo. Dyrk1 inhibitors rescued enlargement, polyploidization, and thrombopoiesis in human neonatal Mks. Mks derived from induced pluripotent stem cells responded in a similar manner. Progenitors undergoing Dyrk1 inhibition demonstrated filamentous actin assembly, MKL1 nuclear translocation, and modulation of MKL1 target genes. Loss-of-function studies confirmed MKL1 involvement in this morphogenetic pathway. Expression of Ablim2, a stabilizer of filamentous actin, increased with Dyrk1 inhibition, and Ablim2 knockdown abrogated the actin, MKL1, and morphogenetic responses to Dyrk1 inhibition. These results delineate a pharmacologically tractable morphogenetic pathway whose manipulation may alleviate clinical problems associated with the limited thrombopoietic capacity of infantile Mks., Introduction Human megakaryocytes (Mks) undergo dramatic changes during ontogenic progression from fetal through adult stages. These changes include diminishing proliferation and a concomitant increase in adult-type morphogenesis (1-3). Adult-type morphogenesis [...]

Published
2022
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7. Segmentation and quantitation pipeline for image analysis from Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer

Author

Cornelison, Robert, primary, Dobbin, Zachary C., primary, Katre, Ashwini A., primary, Jeong, Dae Hoon, primary, Zhang, Yinfeng, primary, Chen, Dongquan, primary, Petrova, Yuliya, primary, Llaneza, Danielle C., primary, Steg, Adam D., primary, Parsons, Laura, primary, Schneider, David A., primary, and Landen, Charles N., primary

Published
2023
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8. Data from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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9. Supplementary Figure 2, Part 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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10. Supplementary Figure 2, Part 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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11. Supplementary Figure Legend for Figure 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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12. Supplementary Figure 1 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies

Author

Bolton, Kelly L., primary, Garcia-Closas, Montserrat, primary, Pfeiffer, Ruth M., primary, Duggan, Máire A., primary, Howat, William J., primary, Hewitt, Stephen M., primary, Yang, Xiaohong R., primary, Cornelison, Robert, primary, Anzick, Sarah L., primary, Meltzer, Paul, primary, Davis, Sean, primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Pharoah, Paul D.P., primary, and Sherman, Mark E., primary

Published
2023
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13. Data from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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14. Supplementary Table 6 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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15. Supplementary Table 3 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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16. Supplementary Table 4 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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17. Supplementary Table 1 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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18. Supplementary Table 2 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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19. Supplementary Table 5 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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20. Supplementary Figure 1 from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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21. Supplementary Figure Legend from Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

Author

Killian, J. Keith, primary, Bilke, Sven, primary, Davis, Sean, primary, Walker, Robert L., primary, Killian, M. Scott, primary, Jaeger, Erich B., primary, Chen, Yidong, primary, Hipp, Jason, primary, Pittaluga, Stefania, primary, Raffeld, Mark, primary, Cornelison, Robert, primary, Smith,, William I., primary, Bibikova, Marina, primary, Fan, Jian-Bing, primary, Emmert-Buck, Michael R., primary, Jaffe, Elaine S., primary, and Meltzer, Paul S., primary

Published
2023
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23. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Author

Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., Munson, Jennifer M., Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., and Munson, Jennifer M.

Abstract

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma, unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drugs drain via lymphatics. Though all drugs interact with the lymphatics, we know little of their impact on them. Here, we show a previously unknown effect of platinums, a widely used class of chemotherapeutics, to directly induce systemic lymphangiogenesis and activation. These changes are dose-dependent, long-lasting, and occur in healthy and cancerous tissue in multiple mouse models of breast cancer. We found similar effects in human ovarian and breast cancer patients whose treatment regimens included platinums. Carboplatin treatment of healthy mice prior to mammary tumor inoculation increased cancer metastasis as compared to no pre-treatment. These platinum-induced phenomena could be blocked by VEGFR3 inhibition. These findings have implications for cancer patients receiving platinums and may support the inclusion of anti-VEGFR3 therapy into treatment regimens or differential design of treatment regimens to alter these potential effects.

Published
2022

24. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Author

Harris, Alexandra R., primary, Esparza, Savieay, additional, Azimi, Mohammad S., additional, Cornelison, Robert, additional, Azar, Francesca N., additional, Llaneza, Danielle C., additional, Belanger, Maura, additional, Mathew, Alexander, additional, Tkachenko, Svyatoslav, additional, Perez, Matthew J., additional, Rosean, Claire Buchta, additional, Bostic, Raegan R., additional, Cornelison, R. Chase, additional, Tate, Kinsley M., additional, Peirce-Cottler, Shayn M., additional, Paquette, Cherie, additional, Mills, Anne, additional, Landen, Charles N., additional, Saucerman, Jeff, additional, Dillon, Patrick M., additional, Pompano, Rebecca R., additional, Rutkowski, Melanie A., additional, and Munson, Jennifer M., additional

Published
2022
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35. Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics

Author

Figueroa, Jonine D., Flanders, Kathleen C., Garcia-Closas, Montserrat, Anderson, William F., Yang, Xiaohong R., Matsuno, Rayna K., Duggan, Máire A., Pfeiffer, Ruth M., Ooshima, Akira, Cornelison, Robert, Gierach, Gretchen L., Brinton, Louise A., Lissowska, Jolanta, Peplonska, Beata, Wakefield, Lalage M., and Sherman, Mark E.

Published
2010
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36. Rhabdomyosarcomas are oncogene addicted to the activation of AVIL.

Author

Zhongqiu Xie, Janczyk, Pawel L., Xinrui Shi, Qiong Wang, Singh, Sandeep, Cornelison, Robert, Jingjing Xu, Mandell, James W., Barr, Frederic G., and Hui Li

Subjects
ONCOGENES, CHROMOSOME inversions, MESENCHYMAL stem cells, GENE fusion, PEOPLE with drug addiction, CELL migration
Abstract

Rhabdomyosarcoma (RMS) is one of the most common pediatric soft-tissue cancer. Previously, we discovered a gene fusion, MARS-AVIL formed by chromosomal inversion in RMS. Suspecting that forming a fusion with a housekeeping gene may be one of the mechanisms to dysregulate an oncogene, we investigated AVIL expression and its role in RMS. We first showed that MARS-AVIL translates into an in-frame fusion protein, which is critical for RMS cell tumorigenesis. Besides forming a gene fusion with the housekeeping gene, MARS, the AVIL locus is often amplified, and its RNA and protein expression are overexpressed in the majority of RMSs. Tumors with AVIL dysregulation exhibit evidence of oncogene addiction: Silencing MARS-AVIL in cells harboring the fusion, or silencing AVIL in cells with AVIL overexpression, nearly eradicated the cells in culture, as well as inhibited in vivo xenograft growth in mice. Conversely, gain-of-function manipulations of AVIL led to increased cell growth and migration, enhanced foci formation in mouse fibroblasts, and most importantly transformed mesenchymal stem cells in vitro and in vivo. Mechanistically, AVIL seems to serve as a converging node functioning upstream of two oncogenic pathways, PAX3-FOXO1 and RAS, thus connecting two types of RMS associated with these pathways. Interestingly, AVIL is overexpressed in other sarcoma cells as well, and its expression correlates with clinical outcomes, with higher levels of AVIL expression being associated with worse prognosis. AVIL is a bona fide oncogene in RMS, and RMS cells are addicted to its activity. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Platinum chemotherapy induces lymphangiogenesis to prime tissues for tumor metastasis

Author

Harris, Alexandra R., Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Esparza, Savieay, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., and Munson, Jennifer M.

Abstract

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drug drains via lymphatics. Though all drugs interact with the lymphatics, we know little of their impact on them. Here, we show a previously unknown effect of platinums, a widely used chemotherapeutic, to directly induce systemic VEGFR3-dependent lymphangiogenesis. These changes are dose-dependent, long-lasting, and occur in healthy and cancerous tissue in multiple mouse models of breast cancer. We saw similar effects in human ovarian and breast cancer patients whose treatment regimens included platinums. Carboplatin treatment results in lymphatic hyperplasia and secretion of pro-chemotactic factors in lymph nodes. Carboplatin treatment of healthy mice prior to mammary tumor inoculation increases cancer metastasis. These findings have broad-reaching implications for cancer patients receiving platinums and support the inclusion of anti-VEGFR3 therapy into treatment regimens. Summary Platinum chemotherapy induces lymphangiogenesis priming tissues for metastasis of breast cancer. Inhibition of VEGFR3 via antibody blockade can reverse these effects.

Published
2019
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39. Platinum chemotherapy induces lymphangiogenesis in cancerous and healthy tissues that can be prevented with adjuvant anti-VEGFR3 therapy

Author

Harris, Alexandra R., primary, Esparza, Savieay, additional, Azimi, Mohammad S., additional, Cornelison, Robert, additional, Azar, Francesca N., additional, Llaneza, Danielle C., additional, Belanger, Maura, additional, Mathew, Alexander, additional, Tkachenko, Svyatoslav, additional, Perez, Matthew J., additional, Rosean, Claire Buchta, additional, Bostic, Raegan R., additional, Cornelison, R. Chase, additional, Tate, Kinsley M., additional, Peirce-Cottler, Shayn M., additional, Paquette, Cherie, additional, Mills, Anne, additional, Landen, Charles N., additional, Saucerman, Jeff, additional, Dillon, Patrick M., additional, Pompano, Rebecca R., additional, Rutkowski, Melanie A., additional, and Munson, Jennifer M., additional

Published
2019
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40. A novel role of HLA class I in the pathology of medulloblastoma

Author

Rood Brian R, Choi Mi, Rushing Elisabeth J, Rajan Bhargavi, Santi Mariarita, Smith Courtney, Cornelison Robert, MacDonald Tobey J, and Vukmanovic Stanislav

Subjects
Medicine
Abstract

Abstract Background MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC class I expression is associated with an unfavorable outcome. We explored the basis of MHC class I association with unfavorable prognostic marker expression in the case of medulloblastoma. Methods We investigated expression of four essential components of MHC class I (heavy chain, β2m, TAP1 and TAP2) in 10 medulloblastoma mRNA samples, a tissue microarray containing 139 medulloblastoma tissues and 3 medulloblastoma cell lines. Further, in medulloblastoma cell lines we evaluated the effects of HLA class I engagement on activation of ERK1/2 and migration in vitro. Results The majority of specimens displayed undetectable or low levels of the heavy chains. Medulloblastomas expressing high levels of HLA class I displayed significantly higher levels of anaplasia and c-myc expression, markers of poor prognosis. Binding of β2m or a specific antibody to open forms of HLA class I promoted phosphorylation of ERK1/2 in medulloblastoma cell line with high levels, but not in the cell line with low levels of HLA heavy chain. This treatment also promoted ERK1/2 activation dependent migration of medulloblastoma cells. Conclusion MHC class I expression in medulloblastoma is associated with anaplasia and c-myc expression, markers of poor prognosis. Peptide- and/or β2m-free forms of MHC class I may contribute to a more malignant phenotype of medulloblastoma by modulating activation of signaling molecules such as ERK1/2 that stimulates cell mobility.

Published
2009
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41. Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

Author

McQueeney, Kelley E., primary, Salamoun, Joseph M., additional, Burnett, James C., additional, Barabutis, Nektarios, additional, Pekic, Paula, additional, Lewandowski, Sophie L., additional, Llaneza, Danielle C., additional, Cornelison, Robert, additional, Bai, Yunpeng, additional, Zhang, Zhong-Yin, additional, Catravas, John D., additional, Landen, Charles N., additional, Wipf, Peter, additional, Lazo, John S., additional, and Sharlow, Elizabeth R., additional

Published
2017
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42. A Salvation Audit

Author

Cornelison, Robert T.

Subjects
A Salvation Audit (Book) -- Book reviews, Books -- Book reviews, Philosophy and religion
Published
1996

44. Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer

Author

Cornelison, Robert, primary, Dobbin, Zachary C., additional, Katre, Ashwini A., additional, Jeong, Dae Hoon, additional, Zhang, Yinfeng, additional, Chen, Dongquan, additional, Petrova, Yuliya, additional, Llaneza, Danielle C., additional, Steg, Adam D., additional, Parsons, Laura, additional, Schneider, David A., additional, and Landen, Charles N., additional

Published
2017
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47. Abstract B39: Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer

Author

Dobbin, Zachary, primary, Cornelison, Robert, additional, Katre, Ashwini K., additional, Schneider, David A., additional, Watters, Karen, additional, Coscia, Fabian, additional, Lengyel, Ernst, additional, Buechlein, Aaron, additional, Fang, Fang, additional, Nephew, Kenneth, additional, and Landen, Charles N., additional

Published
2016
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49. RNAi microarray analysis in cultured mammalian cells

Author

Mousses, Spyro, Caplen, Natasha J., Cornelison, Robert, Weaver, Don, Basik, Mark, Hautaniemi, Sampsa, Elkahloun, Abdel G., Lotufo, Roberto A., Choudary, Ashish, Dougherty, Edward R., Suh, Ed, and Kallioniemi, Olli

Subjects
Methodology -- Analysis, Cells -- Genetic aspects, DNA microarrays -- Genetic aspects, Genetic research -- Analysis, Genomes -- Research, Health
Abstract

Research has been conducted on RNA interference which is mediated by small interfering RNAs. The authors describe the development of the microarray-based technology for investigating large-scale high-throughput functional genomes via the use of RNA interference.

Published
2003

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