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3. Early characterization and prediction of glioblastoma and brain metastases treatment efficacy using medical imaging-based radiomics and artificial intelligence algorithms

Author

Moreau, Noémie N, primary, Valable, Samuel, additional, Jaudet, Cyril, additional, Dessoude, Loïse, additional, Herault, Romain, additional, Modzelewski, Romain, additional, Stefan, Dinu, additional, Thariat, Juliette, additional, Lechervy, Alexis, additional, and Corroyer-Dulmont, Aurélien, additional

Published
2024
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5. Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

Author

Corroyer-Dulmont, Aurélien, Valable, Samuel, Fantin, Jade, Chatre, Laurent, Toutain, Jérôme, Teulier, Sylvain, Bazille, Céline, Letissier, Elise, Levallet, Jérôme, Divoux, Didier, Ibazizène, Méziane, Guillouet, Stéphane, Perrio, Cécile, Barré, Louisa, Serres, Sébastien, Sibson, Nicola R., Chapon, Françoise, Levallet, Guénaëlle, and Bernaudin, Myriam

Published
2021
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6. Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies.

Author

Fantin, Jade, Toutain, Jérôme, Pérès, Elodie A., Bernay, Benoit, Mehani, Sarina Maya, Helaine, Charly, Bourgeois, Mickael, Brunaud, Carole, Chazalviel, Laurent, Pontin, Julien, Corroyer-Dulmont, Aurélien, Valable, Samuel, Cherel, Michel, and Bernaudin, Myriam

Subjects
COPPER, BRAIN metastasis, PROTEOMICS, HYPOXEMIA, MAGNETIC resonance imaging, LUNGS
Abstract

Background: Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a role in tumor growth and treatment resistance with multimodal PET and MRI imaging, immunohistochemical and proteomic approaches in a human lung cancer (H2030-BrM3)-derived BM model in rats. Results: First, in vitro studies confirmed that H2030-BrM3 cells respond to hypoxia with increasing expression of HIF-1, HIF-2 and their target genes. Proteomic analyses revealed, among expression changes, proteins associated with metabolism, oxidative stress, metal response and hypoxia signaling in particular in cortical BM. [64Cu][Cu(ATSM)] PET revealed a significant uptake by cortical BM (p < 0.01), while no uptake is observed in striatal BM 23 days after tumor implantation. Pimonidazole, HIF-1α, HIF-2α, CA-IX as well as GFAP, CTR1 and DMT1 immunostainings are positive in both BM. Conclusion: Overall, [64Cu][Cu(ATSM)] imaging and proteomic results showed the presence of hypoxia and protein expression changes linked to hypoxia and oxidative stress in BM, which are more pronounced in cortical BM compared to striatal BM. Moreover, it emphasized the interest of [64Cu][Cu(ATSM)] PET to characterize TME of BM and depict inter-metastasis heterogeneity that could be useful to guide treatments. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Supplementary Methods from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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10. Data from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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11. Supplementary Figure 1 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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12. Supplementary Figure 4 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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13. Supplementary Table 1 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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14. Supplementary Figure 5 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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15. Supplementary Figure 2 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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16. Supplementary Figure Legends 1-5 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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17. Supplementary Figure 3 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

Author

Kluza, Jérome, primary, Corazao-Rozas, Paola, primary, Touil, Yasmine, primary, Jendoubi, Manel, primary, Maire, Cyril, primary, Guerreschi, Pierre, primary, Jonneaux, Aurélie, primary, Ballot, Caroline, primary, Balayssac, Stéphane, primary, Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, primary, Bernaudin, Myriam, primary, Malet-Martino, Myriam, primary, de Lassalle, Elisabeth Martin, primary, Maboudou, Patrice, primary, Formstecher, Pierre, primary, Polakowska, Renata, primary, Mortier, Laurent, primary, and Marchetti, Philippe, primary

Published
2023
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20. Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine‐18 fluoromisonidazole‐positron emission tomography: A cross‐validation study?

Author

Valable, Samuel, primary, Toutain, Jérôme, additional, Divoux, Didier, additional, Chazalviel, Laurent, additional, Corroyer‐Dulmont, Aurélien, additional, Chakhoyan, Ararat, additional, Guillouet, Stéphane, additional, Bernaudin, Myriam, additional, Barbier, Emmanuel L., additional, and Touzani, Omar, additional

Published
2022
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21. Magnetic resonance imaging of hypoxia in acute stroke: a cross‐validation study against FMISO‐positron emission tomography

Author

Samuel, Valable, Toutain, Jérôme, Divoux, Didier, Chazalviel, Laurent, Corroyer-Dulmont, Aurélien, Chakhoyan, Ararat, Guillouet, Stéphane, Bernaudin, Myriam, Barbier, Emmanuel, Touzani, Omar, Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons (LDM-TEP), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN)

Subjects
hypoxia, [SDV]Life Sciences [q-bio], tissue oxygenation, FMISO-PET, stroke, MRI
Abstract

CERVOXY; International audience; Acute ischemic stroke results in ischemic core surrounded by a tissue at risk, named the penumbra, which is potentially salvageable. One way to differentiate the tissues is to measure the hypoxia status. The purpose of the study is to correlate the abnormal brain tissue volume derived from magnetic resonance-based imaging of brain oxygen saturation (StO2-MRI) to the [18F]FMISO positron emission tomography (PET) volume for hypoxia imaging validation, and to analyse the ability of StO2-MRI to depict the different hypoxic tissue types in the acute phase of stroke.In a pertinent model of stroke in the rat, the volume of tissue with decreased StO2-MRI signal and that with increased uptake of [18F]FMISO were equivalent and correlated (r=0.706; p=0.015). The values of StO2 in the tissue at risk were significantly greater than those quantified in the core of the lesion, and less than those of the healthy tissue (52.3±2.0%; 43.3±1.9% and 67.9±1.4%, respectively). A threshold value of StO2 of ≈60% as the cut-off for the identification of the tissue at risk was calculated. Tissue volumes with reduced StO2-MRI correlated with the final lesion (r=0.964, p

Published
2023

22. Deep Learning Denoising Improves and Homogenizes Patient [ 18 F]FDG PET Image Quality in Digital PET/CT.

Author

Weyts, Kathleen, Quak, Elske, Licaj, Idlir, Ciappuccini, Renaud, Lasnon, Charline, Corroyer-Dulmont, Aurélien, Foucras, Gauthier, Bardet, Stéphane, and Jaudet, Cyril

Subjects
POSITRON emission tomography, DEEP learning, CONVOLUTIONAL neural networks, SIGNAL convolution, RADIATION protection
Abstract

Given the constant pressure to increase patient throughput while respecting radiation protection, global body PET image quality (IQ) is not satisfactory in all patients. We first studied the association between IQ and other variables, in particular body habitus, on a digital PET/CT. Second, to improve and homogenize IQ, we evaluated a deep learning PET denoising solution (Subtle PETTM) using convolutional neural networks. We analysed retrospectively in 113 patients visual IQ (by a 5-point Likert score in two readers) and semi-quantitative IQ (by the coefficient of variation in the liver, CVliv) as well as lesion detection and quantification in native and denoised PET. In native PET, visual and semi-quantitative IQ were lower in patients with larger body habitus (p < 0.0001 for both) and in men vs. women (p ≤ 0.03 for CVliv). After PET denoising, visual IQ scores increased and became more homogeneous between patients (4.8 ± 0.3 in denoised vs. 3.6 ± 0.6 in native PET; p < 0.0001). CVliv were lower in denoised PET than in native PET, 6.9 ± 0.9% vs. 12.2 ± 1.6%; p < 0.0001. The slope calculated by linear regression of CVliv according to weight was significantly lower in denoised than in native PET (p = 0.0002), demonstrating more uniform CVliv. Lesion concordance rate between both PET series was 369/371 (99.5%), with two lesions exclusively detected in native PET. SUVmax and SUVpeak of up to the five most intense native PET lesions per patient were lower in denoised PET (p < 0.001), with an average relative bias of −7.7% and −2.8%, respectively. DL-based PET denoising by Subtle PETTM allowed [18F]FDG PET global image quality to be improved and homogenized, while maintaining satisfactory lesion detection and quantification. DL-based denoising may render body habitus adaptive PET protocols unnecessary, and pave the way for the improvement and homogenization of PET modalities. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Deep Hybrid Learning prediction of patient specific quality assurance in radiotherapy: implementation in clinical routine

Author

Moreau, Noémie, Bonnor, Laurine, Jaudet, Cyril, Lechippey, Laetitia, Falzone, Nadia, Batalla, Alain, Bertaut, Cindy, Corroyer-Dulmont, Aurélien, Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Site Louis Pasteur [CHPC], CH Centre Hospitalier Public du Cotentin (CHPC), Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (ISTCT), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

CERVOXY; National audience

Published
2022

24. Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine‐18 fluoromisonidazole‐positron emission tomography: A cross‐validation study?

Author

Valable, Samuel, Toutain, Jérôme, Divoux, Didier, Chazalviel, Laurent, Corroyer‐Dulmont, Aurélien, Chakhoyan, Ararat, Guillouet, Stéphane, Bernaudin, Myriam, Barbier, Emmanuel L., and Touzani, Omar

Subjects
MAGNETIC resonance imaging, ISCHEMIC stroke, POSITRON emission tomography, HYPOXEMIA, OXYGEN saturation
Abstract

Acute ischemic stroke results in an ischemic core surrounded by a tissue at risk, named the penumbra, which is potentially salvageable. One way to differentiate the tissues is to measure the hypoxia status. The purpose of the current study is to correlate the abnormal brain tissue volume derived from magnetic resonance‐based imaging of brain oxygen saturation (StO2‐MRI) to the fluorine‐18 fluoromisonidazole ([18F]FMISO) positron emission tomography (PET) volume for hypoxia imaging validation, and to analyze the ability of StO2‐MRI to depict the different hypoxic tissue types in the acute phase of stroke. In a pertinent model of stroke in the rat, the volume of tissue with decreased StO2‐MRI signal and that with increased uptake of [18F]FMISO were equivalent and correlated (r = 0.706; p = 0.015). The values of StO2 in the tissue at risk were significantly greater than those quantified in the core of the lesion, and were less than those for healthy tissue (52.3% ± 2.0%; 43.3% ± 1.9%, and 67.9 ± 1.4%, respectively). A threshold value for StO2 of ≈60% as the cut‐off for the identification of the tissue at risk was calculated. Tissue volumes with reduced StO2‐MRI correlated with the final lesion (r = 0.964, p < 0.0001). The findings show that the StO2‐MRI approach is sensitive for the detection of hypoxia and for the prediction of the final lesion after stroke. Once validated in acute clinical settings, this approach might be used to enhance the stratification of patients for potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Radioimmunotherapy for Brain Metastases: The Potential for Inflammation as a Target of Choice

Author

Corroyer-Dulmont, Aurélien, primary, Jaudet, Cyril, additional, Frelin, Anne-Marie, additional, Fantin, Jade, additional, Weyts, Kathleen, additional, Vallis, Katherine A., additional, Falzone, Nadia, additional, Sibson, Nicola R., additional, Chérel, Michel, additional, Kraeber-Bodéré, Françoise, additional, Batalla, Alain, additional, Bardet, Stéphane, additional, Bernaudin, Myriam, additional, and Valable, Samuel, additional

Published
2021
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31. Caractérisation de l’hypoxie et stratégies pour lever la radiorésistance dans les glioblastomes et les métastases cérébrales

Author

Bernaudin, Myriam, Berro David, Hassanein, Collet, Solène, Corroyer-Dulmont, Aurélien, Leblond M, Marine, Emery, Evelyne, Pérès, Elodie A., Levallet, Guénaëlle, Pasquet, Nolwenn, Samuel, Valable, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Service de Neurochirurgie [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Brunaud, Carole, Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), and Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY; National audience; L’hypoxie est un élément central de la croissance tumorale, impliquée aussi bien dans la progression tumorale que dans la résistance aux traitements conventionnels. Nos recherches visent à aborder l’hypoxie par plusieurs approches. Tout d’abord, nous cherchons à caractériser de l’échelle préclinique à l’échelle clinique, l’hypoxie et ses relations avec les cellules tumorales mais aussi avec leur microenvironnement dont la vascularisation, l’inflammation. Pour cela, nous utilisons des marqueurs histo-moléculaires mais également l’imagerie multimodale (IRM, TEP) pour évaluer l’hétérogénéité tumorale interpatient mais également spatiale des tumeurs cérébrales primitives de haut grade mais également des métastases cérébrales (Bekaert et al., 2017; Ponte et al., 2017; Pérès et al., 2019 ; Collet S et al., 2021 ; Corroyer-Dulmont A et al., 2021). En parallèle, nous développons des stratégies visant à contourner les effets de l’hypoxie sur la résistance aux traitements et en particulier, la radiothérapie. A ce titre, nous nous intéressons à l’hadronthérapie. Ainsi, nous avons pu montrer in vitro que les ions carbone sont plus efficaces que les photons sur les cellules tumorales hypoxiques (Valable S et al., 2020). Nous évaluons l’impact de l’hadronthérapie avec ou sans traitements combinés sur le caractère souche des cellules tumorales connu pour participer à cette radiorésistance induite par l’hypoxie. Nous développons également des stratégies pour réoxygéner et/ou radiosensibiliser les tumeurs. A titre d’exemple, nous avons récemment utilisé une stratégie nanoparticulaire afin de réoxygéner les glioblastomes (Anfray et al., 2020) mais aussi apporter du gadolinium, utilisé comme agent de radiosensibilisation. Des études sont actuellement en cours pour évaluer l’efficacité de cette approche théranostique que ce soit in vitro sur les cellules tumorales mais aussi in vivo chez le rongeur.En conclusion, nos travaux de recherche combinent des approches cellulaires aux études cliniques en passant par des études précliniques afin d’identifier l’hypoxie dans différents types de tumeurs cérébrales (glioblastomes, métastases cérébrales) et de développer des stratégies visant à atténuer les effets de l’hypoxie sur la résistance aux traitements.

Published
2021

32. Artificial intelligence-based PET denoising could allow a two-fold reduction in [18F]FDG PET acquisition time in digital PET/CT.

Author

Weyts, Kathleen, Lasnon, Charline, Ciappuccini, Renaud, Lequesne, Justine, Corroyer-Dulmont, Aurélien, Quak, Elske, Clarisse, Bénédicte, Roussel, Laurent, Bardet, Stéphane, and Jaudet, Cyril

Subjects
ARTIFICIAL neural networks, LEAN body mass, CONVOLUTIONAL neural networks, INTRACLASS correlation, DEEP learning, POSITRON emission tomography
Abstract

Purpose: We investigated whether artificial intelligence (AI)-based denoising halves PET acquisition time in digital PET/CT. Methods: One hundred ninety-five patients referred for [18F]FDG PET/CT were prospectively included. Body PET acquisitions were performed in list mode. Original "PET90" (90 s/bed position) was compared to reconstructed ½-duration PET (45 s/bed position) with and without AI-denoising, "PET45AI and PET45". Denoising was performed by SubtlePET™ using deep convolutional neural networks. Visual global image quality (IQ) 3-point scores and lesion detectability were evaluated. Lesion maximal and peak standardized uptake values using lean body mass (SULmax and SULpeak), metabolic volumes (MV), and liver SULmean were measured, including both standard and EARL1 (European Association of Nuclear Medicine Research Ltd) compliant SUL. Lesion-to-liver SUL ratios (LLR) and liver coefficients of variation (CVliv) were calculated. Results: PET45 showed mediocre IQ (scored poor in 8% and moderate in 68%) and lesion concordance rate with PET90 (88.7%). In PET45AI, IQ scores were similar to PET90 (P = 0.80), good in 92% and moderate in 8% for both. The lesion concordance rate between PET90 and PET45AI was 836/856 (97.7%), with 7 lesions (0.8%) only detected in PET90 and 13 (1.5%) exclusively in PET45AI. Lesion EARL1 SULpeak was not significantly different between both PET (P = 0.09). Lesion standard SULpeak, standard and EARL1 SULmax, LLR and CVliv were lower in PET45AI than in PET90 (P < 0.0001), while lesion MV and liver SULmean were higher (P < 0.0001). Good to excellent intraclass correlation coefficients (ICC) between PET90 and PET45AI were observed for lesion SUL and MV (ICC ≥ 0.97) and for liver SULmean (ICC ≥ 0.87). Conclusion: AI allows [18F]FDG PET duration in digital PET/CT to be halved, while restoring degraded ½-duration PET image quality. Future multicentric studies, including other PET radiopharmaceuticals, are warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Hypoxia image-Guided Radiotherapy for the treatment of brain metastases from primary lung cancer, a preclinical study

Author

Corroyer-Dulmont, Aurélien, Valable, Samuel, Toutain, Jérôme, Divoux, Didier, Ibazizene, Méziane, Guillouet, Stéphane, Perrio, Cécile, Barre, Louisa, Levallet, Guenaelle, Bernaudin, Myriam, Brunaud, Carole, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Hypoxie, physiopathologies cérébrovasculaire et tumorale (CERVOxy), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons (LDM-TEP), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Département de Pathologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Couteau, Florence, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT)

Subjects
[SDV] Life Sciences [q-bio], [SCCO.NEUR]Cognitive science/Neuroscience, [SDV]Life Sciences [q-bio], [SCCO.NEUR] Cognitive science/Neuroscience
Abstract

CERVOXY/LDM TEP; International audience

Published
2020

36. VCAM-1 targeted alpha-particle therapy for early brain metastases

Author

Corroyer-Dulmont, Aurélien, primary, Valable, Samuel, additional, Falzone, Nadia, additional, Frelin-Labalme, Anne-Marie, additional, Tietz, Ole, additional, Toutain, Jérôme, additional, Soto, Manuel Sarmiento, additional, Divoux, Didier, additional, Chazalviel, Laurent, additional, Pérès, Elodie A, additional, Sibson, Nicola R, additional, Vallis, Katherine A, additional, and Bernaudin, Myriam, additional

Published
2019
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37. Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

Author

Gérard, Michael, primary, Corroyer-Dulmont, Aurélien, additional, Lesueur, Paul, additional, Collet, Solène, additional, Chérel, Michel, additional, Bourgeois, Mickael, additional, Stefan, Dinu, additional, Limkin, Elaine Johanna, additional, Perrio, Cécile, additional, Guillamo, Jean-Sébastien, additional, Dubray, Bernard, additional, Bernaudin, Myriam, additional, Thariat, Juliette, additional, and Valable, Samuel, additional

Published
2019
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38. Improved outcome of 131 I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma

Author

Corroyer-Dulmont, Aurélien, Falzone, Nadia, Kersemans, Veerle, Thompson, James, Allen, Danny, Able, Sarah, Kartsonaki, Christiana, Malcolm, Javian, Kinchesh, Paul, Hill, Mark, Vojnovic, Boris, Smart, Sean, Gaze, Mark, Vallis, Katherine, University of Oxford [Oxford], Hypoxie, physiopathologies cérébrovasculaire et tumorale (CERVOxy), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre for Cancer Genetic Epidemiology, University of Cambridge [UK] (CAM), Nuffield Department of Population Health [Oxford], University College London Hospitals (UCLH), University of Oxford, Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Neuroblastoma, Radiotherapy, 131I-mIBG, [SCCO.NEUR]Cognitive science/Neuroscience, Image-guided radiotherapy
Abstract

CERVOXY (unité d'origine); International audience

Published
2017

39. Radionuclide spatial distribution and dose deposition for in vitro assessments of 212Pb‐αVCAM‐1 targeted alpha therapy.

Author

Frelin‐Labalme, Anne‐Marie, Roger, Thomas, Falzone, Nadia, Quan Lee, Boon, Sibson, Nicola R., Vallis, Katherine A., Bernaudin, Myriam, Valable, Samuel, and Corroyer‐Dulmont, Aurélien

Subjects
MONTE Carlo method, SPATIAL distribution (Quantum optics), RADIOISOTOPES, SILICON detectors, ALPHA rhythm, ABSORBED dose, CELL culture, ENERGY transfer
Abstract

Purpose: Targeted alpha therapy (TAT) takes advantage of the short‐range and high‐linear energy transfer of α‐particles and is increasingly used, especially for the treatment of metastatic lesions. Nevertheless, dosimetry of α‐emitters is challenging for the very same reasons, even for in vitro experiments. Assumptions, such as the uniformity of the distribution of radionuclides in the culture medium, are commonly made, which could have a profound impact on dose calculations. In this study we measured the spatial distribution of α‐emitting 212Pb coupled to an anti‐VCAM‐1 antibody (212Pb‐αVCAM‐1) and its evolution over time in the context of in vitro irradiations. Methods: Two experimental setups were implemented without cells to measure α‐particle count rates and energy spectra in culture medium containing 15 kBq of 212Pb‐α‐VCAM‐1. Silicon detectors were placed above and below cell culture dishes for 20 h. One of the dishes had a 2.5‐µm‐thick mylar‐base allowing easy detection of the α‐particles. Monte Carlo simulations were performed to analyze experimental spectra. Experimental setups were modeled and α‐energy spectra were simulated in the silicon detectors for different decay positions in the culture medium. Simulated spectra were then used to deconvolute experimental spectra to determine the spatial distribution of 212Pb‐αVCAM‐1 in the medium. This distribution was finally used to calculate the dose deposition in cell culture experiments. Results: Experimental count rates and energy spectra showed differences in measurements taken at the top and the bottom of dishes and temporal variations that did not follow 212Pb decay. The radionuclide spatial distribution was shown to be composed of a uniform distribution and concentration gradients at the top and the bottom, which were subjected to temporal variations that may be explained by gravity and electrostatic attraction. The absorbed dose in cells calculated from this distribution was compared with the dose expected for a uniform and static distribution and found to be 1.75 times higher, which is highly significant to interpret biological observations. Conclusions: This study demonstrated that accurate dosimetry of α‐emitters requires the experimental determination of radionuclide spatial and temporal distribution and highlighted that in vitro assessment of dose for TAT cannot only rely on a uniform distribution of activity in the culture medium. The reliability and reproducibility of future experiments should benefit from specifically developed dosimetry tools and methods. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases

Author

Falzone, Nadia, primary, Ackerman, Nicole L., additional, Rosales, Liset de la Fuente, additional, Bernal, Mario A., additional, Liu, Xiaoxuan, additional, Peeters, Sarah GJA, additional, Soto, Manuel Sarmiento, additional, Corroyer-Dulmont, Aurélien, additional, Bernaudin, Myriam, additional, Grimoin, Elisa, additional, Touzani, Omar, additional, Sibson, Nicola R., additional, and Vallis, Katherine A., additional

Published
2018
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42. L’hypoxie favorise le phénotype macrophagique pro-tumoral par la polarisation des macrophages M0 et la ré-éducation des macrophages M1 dans les glioblastomes

Author

Leblond, M.M., Gerault, An, Corroyer-Dulmont, Aurélien, Petit, Edwige, Bernaudin, Myriam, Valable, Samuel, Couteau, Florence, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY; National audience

Published
2016

43. MRI-guided radiotherapy of the SK-N-SH neuroblastoma xenograft model using a small animal radiation research platform

Author

Corroyer-Dulmont, Aurélien, primary, Falzone, Nadia, additional, Kersemans, Veerle, additional, Thompson, James, additional, Hill, Mark, additional, Allen, P Danny, additional, Beech, John, additional, Gilchrist, Stuart, additional, Kinchesh, Paul, additional, Vojnovic, Boris, additional, Tullis, Iain, additional, Gaze, Mark N, additional, Smart, Sean, additional, and Vallis, Katherine A, additional

Published
2017
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44. Imaging of brain oxygenation with magnetic resonance imaging: A validation with positron emission tomography in the healthy and tumoural brain

Author

Valable, Samuel, primary, Corroyer-Dulmont, Aurélien, additional, Chakhoyan, Ararat, additional, Durand, Lucile, additional, Toutain, Jérôme, additional, Divoux, Didier, additional, Barré, Louisa, additional, MacKenzie, Eric T, additional, Petit, Edwige, additional, Bernaudin, Myriam, additional, Touzani, Omar, additional, and Barbier, Emmanuel L, additional

Published
2016
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45. Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models

Author

Chakhoyan, Ararat, primary, Corroyer-Dulmont, Aurélien, additional, Leblond, Marine M, additional, Gérault, Aurélie, additional, Toutain, Jérôme, additional, Chazaviel, Laurent, additional, Divoux, Didier, additional, Petit, Edwige, additional, MacKenzie, Eric T, additional, Kauffmann, François, additional, Delcroix, Nicolas, additional, Bernaudin, Myriam, additional, Touzani, Omar, additional, and Valable, Samuel, additional

Published
2016
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47. Multimodal imaging based on MRI and PET reveals [18F]FLT PET as a specific and early indicator of treatment efficacy in a preclinical model of recurrent glioblastoma

Author

Corroyer-Dulmont, Aurélien, primary, Pérès, Elodie A., additional, Gérault, Aurélie N., additional, Savina, Ariel, additional, Bouquet, Fanny, additional, Divoux, Didier, additional, Toutain, Jérôme, additional, Ibazizène, Méziane, additional, MacKenzie, Eric T., additional, Barré, Louisa, additional, Bernaudin, Myriam, additional, Petit, Edwige, additional, and Valable, Samuel, additional

Published
2015
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48. Imaging Modalities to Assess Oxygen Status in Glioblastoma

Author

Corroyer-Dulmont, Aurélien, primary, Chakhoyan, Ararat, additional, Collet, Solène, additional, Durand, Lucile, additional, MacKenzie, Eric T., additional, Petit, Edwige, additional, Bernaudin, Myriam, additional, Touzani, Omar, additional, and Valable, Samuel, additional

Published
2015
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50. Noninvasive assessment of hypoxia with 3-[18F]-fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([18F]-FMISO): a PET study in two experimental models of human glioma

Author

Corroyer-Dulmont, Aurélien, primary, Pérès, Elodie A., additional, Petit, Edwige, additional, Durand, Lucile, additional, Marteau, Léna, additional, Toutain, Jérôme, additional, Divoux, Didier, additional, Roussel, Simon, additional, MacKenzie, Eric T., additional, Barré, Louisa, additional, Bernaudin, Myriam, additional, and Valable, Samuel, additional

Published
2013
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