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To verify whether beta-endorphin plasma levels influence the presence of anginal symptoms. 74 consecutive male patients were studied. All patients had previously documented coronary artery disease and reproducible exerciseinduced myocardial ischemia. Thirty-five patients (Group I) had a history of angina and reported anginal symptoms during exercise stress testing; 39 patients (Group II) were asymptomatic and had documented silent myocardial ischemia during exercise. Baseline beta-endorphin plasma levels were measured in blood ramples taken before exercise stress testing and analyzed by beta-endorphin-I125-RIA Kit-NEN (a radioimmunoassay method).