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Background: the development of specialised nutritional support techniques allows the maintenance of an adequate supply of nutrients in those patients in whom oral feeding is not possible or is insufficient in relation to their requirements, trying to improve the quality of life, especially in those with chronic diseases. Methods: single-center clinical study carried out in a clinical-nutritional center consisting of a medically supervised nasogastric-duodenal tube feeding treatment for overweight, obesity and increased body fat percentage in patients requiring it by means of duodeno-enteral feeding, expecting losses of more than 10 %. Results: twenty-nine patients completed the protocol (20.4 % male and 79.6 % female) with a mean age of 38 years (SD: 12.4); 87.2 kg (SD: 18.5) mean weight; 37.9 kg (SD: 4.8) mean iFat%; 32.4 (SD: 5.4) iMean body mass index (BMI); 100 cm (SD: 16.0) iMean waist; 113.6 cm (SD: 10.4) iMean hip; 33.8 cm (SD: 3.9) iMean upper arm circumference; 65.5 cm (SD: 7.5) iMean thigh circumference; 9.7 (SD: 4.8) iVisceral fat index; and 22.9 days (SD: 13.9) mean treatment. A mean of 22.9 (SD: 13.9) days of MESUDEFT influences weight loss, fat loss, visceral fat loss and decreased arm, hip and thigh circumferences (p < 0.05) (i: initial). Conclusions: MESUDEFT is shown to be an effective alternative as a sole treatment or as an adjunct prior to bariatric surgery for obesity or overweight treatment with a minimum of 10 % loss of BMI and fat mass at completion and 3-6 months follow-up., Antecedentes: el desarrollo de técnicas especializadas de soporte nutricional permite mantener un aporte adecuado de nutrientes en aquellos pacientes en los que la alimentación oral no es posible o es insuficiente en relación a sus requerimientos, intentando mejorar la calidad de vida, especialmente de aquellos con enfermedades crónicas. Métodos: estudio clínico unicéntrico prospectivo realizado en un centro clínico-nutricional consistente en un tratamiento con alimentación por sonda nasogástrica-duodenal médicamente supervisado para el sobrepeso, la obesidad y el aumento del porcentaje de grasa corporal en pacientes que lo requieran mediante alimentación duodenoenteral, durante un mes aproximado, con previsión de pérdidas superiores al 10 % y con control posterior entre los tres y los seis meses siguientes. Resultados: veintinueve pacientes completaron el protocolo (20,4 % varones y 79,6 % mujeres) con una edad media de 38 años (DE: 12,4); 87,2 kg (DE: 18,5) iPeso medio; 37,9 kg (DE: 4,8) iGrasa% media; 32,4 (DE: 5,4) iIMC medio; 100 cm (DE: 16,0) iCintura media; 113,6 cm (DE: 10,4) iCadera media; 33,8 cm (DE: 3,9) iCircunferencia braquial media; 65,5 cm (DE: 7,5) circunferencia muslo media; 9,7 (DE: 4,8) iÍndice de grasa visceral; y 22,9 días (DE: 13,9) de tratamiento medio. Una media de 22,9 (DE: 13,9) días de MESUDEFT influye en la pérdida de peso, la pérdida de grasa, la pérdida de grasa visceral y la disminución de las circunferencias del brazo, la cadera y el muslo (p < 0,05) (i: inicial). Conclusiones: MESUDEFT se muestra como una alternativa eficaz como tratamiento único o como coadyuvante previo a la cirugía bariátrica de la obesidad o tratamiento del sobrepeso con una pérdida mínima del 10 % del índice de masa corporal (IMC) y de la masa grasa al finalizar y con control durante los siguientes 3-6 meses.

Background: COVID-19 disease is a serious global health problem. Few treatments have been shown to reduce mortality and accelerate time to recovery. The aim of this study was to evaluate the potential effect of a food supplement (probiotics, prebiotics, vitamin D, zinc and selenium) in patients admitted with COVID-19. Methods: A prospective randomized non-blinded clinical trial was conducted in a sample of 162 hospitalized patients diagnosed with COVID-19 recruited over eight months. All patients received standard treatment, but the intervention group (n = 67) was given one food supplement stick daily during their admission. After collecting the study variables, a statistical analysis was performed comparing the intervention and control groups and a multivariate analysis controlling for variables that could act as confounding factors. Results: ROC curve analysis with an area under the curve (AUC) value of 0.840 (p < 0.001; 95%CI: 0.741–0.939) of the food supplement administration vs. recovery indicated good predictive ability. Moreover, the intervention group had a shorter duration of digestive symptoms compared with the control group: 2.6 ± 1.3 vs. 4.3 ± 2.2 days (p = 0.001); patients with non-severe disease on chest X-ray had shorter hospital stays: 8.1 ± 3.9 vs. 11.6 ± 7.4 days (p = 0.007). Conclusions: In this trial, the administration of a food supplement (Gasteel Plus®) was shown to be a protective factor in the group of patients with severe COVID-19 and allowed early recovery from digestive symptoms and a shorter hospital stay in patients with a normal–mild–moderate chest X-ray at admission (ClinicalTrials.gov number, NCT04666116).

Obesity is caused by fat accumulation. BMI Z-score is used to classify the different degrees of weight status in children and adolescents. However, this parameter does not always express the true percentage of body fat. Our objective was to determine the degree of agreement between the fat mass percentage measured by DXA and the stratification of weight according to BMI Z-score in the pediatric age group. We designed a descriptive cross-sectional study. The patients were classified as underweight/normal weight with Z-scores between −2 and +0.99, overweight from 1 to 1.99, obese from 2 to 2.99, and very obese ≥3. We included 551 patients (47% girls), with a mean age of 11.5 ± 2.8 years (3.7–18 years). Higher BMI Z-scores were associated with a higher percentage of total fat (p < 0.001). However, there were important overlaps between both parameters, such that the BMI Z-score classified patients with the same percentage of total fat mass as having a different nutritional status classification. In conclusion, the stratification of weight status according to BMI Z-score revealed that 46.7% of patients had a fat percentage that did not correspond to their classification. For a more accurate weight assessment in clinical practice, we recommend combining anthropometric indices with diagnostic tools that better correlate with DXA, such as electrical bioimpedance.

Background. Pharmacological non-adherence in chronic diseases is 40–65%. No predictive profile of non-adherence exists in patients with multiple chronic diseases. Our study aimed to quantify the prevalence of non-adherence to pharmacological treatment and its associated factors in patients who visit pharmacies in Spain. Methods. This observational cross-sectional study included patients with one or more chronic diseases. The variables analyzed were demographics, diseases involved, self-medication, information about disease, and lifestyle. The main variable was adherence using the Morisky–Green test. A total of 132 pharmacies collaborated, providing 6327 patients representing all Spain regions (April–December 2016). Bivariate and multivariate analyses were performed and the area under the receiver operating characteristic (ROC) curve was calculated. Results. Non-adherence was 48.4% (95% confidence interval (CI): 47.2–49.7%). The variables that reached significance in the multivariate model were: difficulty in taking medication, self-medication, desire for more information, smoking, lower physical activity, younger age and number of chronic treatments. Discrimination was satisfactory (area under the ROC curve = 70%). Our study found that 50% patients was non-adherent and we obtained a profile of variables associated with therapeutic non-adherence. Conclusions. It is cause for concern that in patients with multiple diseases and taking multiple medications, there is an association between non-adherence, self-medication and worse lifestyle.

Antecedentes. El olivo constituye una fuente de compuestos bioactivos, tanto en su fruto, como en sus subproductos. Los extractos de aceitunas son ricos en polifenoles y no son tóxicos. Algunos de sus compuestos han mostrado beneficios para la salud en modelos celulares y animales. Así, los polifenoles de la oliva presentan actividad antiinflamatoria, previenen la apoptosis por estrés oxidativo, favorecen el neurodesarrollo y neuroprotección y tienen efecto antiadipogénico en diferentes modelos celulares, protegiendo contra el aumento de peso y la acumulación de grasa. Objetivos. Se han planteado los siguientes objetivos: Evaluar la bioseguridad in vitro e in vivo de extractos de huesos de aceituna ricos en polifenoles. Analizar el posible efecto antiadipogénico de los polifenoles del olivo en pez cebra midiendo la ganancia de peso, colesterol, triglicéridos y ácidos grasos. Evaluar la influencia de los extractos de aceituna en los mecanismos de digestión y absorción de polisacáridos y grasas mediante la cuantificación de amilasa, glucosa, fosfolipasa y colesterol en el modelo de pez medaka. Comprobar la actividad antiadipogénica de dichos extractos, utilizando la diferenciación a adipocitos de la línea celular 3T3-L 1 de fibroblastos de ratón. Evaluar el posible efecto de los extractos de oliva ricos en polifenoles sobre el metabolismo de los lípidos en pez medaka cuantificando la expresión de genes lipogénicos y lipolíticos. Material y métodos. Para el primer objetivo, se ha evaluado la citotoxicidad mediante adición de extracto de hueso de olivas disuelto en PBS (0-400 mg/1) a un cultivo de la línea celular THP1-XBlue-CD14 y evaluación de la viabilidad celular mediante la reacción de reducción de la resazurina por las células vivas. La bioseguridad se ha evaluado en pez cebra, incubando huevos fecundados en extracto de O a 100 mg/I durante 24 a 72 horas y midiendo los parámetros: a) letales (embriones muertos, huevos coagulados), b) subletales (movimientos espont

Background Studies validating indirect methods to identify nonadherence in chronic patients who visit pharmacies are lacking. The aim of this study was to validate self-reported adherence and assess the variables associated with both overestimation and underestimation of good adherence when using this method. Materials and methods An observational, cross-sectional study was undertaken to validate self-reported adherence in 132 community pharmacies throughout Spain in 6237 chronic patients. The Morisky-Green test was used as the validation method and through a 2 × 2 table, the validity indicators, predictive values, and likelihood ratios were calculated. To assess the variables associated with both overestimation and underestimation of good adherence, multivariate logistic regression analysis and calculation of the area under the ROC curve were used to evaluate discriminatory capacity. Results Sensitivity was 27.8% (95% CI: 26.2–29.4) and specificity was 93.9% (95% CI: 93.1–94.7). Discrepancy analysis obtained a significant overestimation of good adherence (p < 0.001). The factors associated with overestimating good adherence were performing a mnemonic trick (p < 0.001), not self-medicating (p < 0.001), a high level of physical activity (p < 0.001), and an older age (p = 0.014). Factors associated with underestimation were self-medication (p < 0.001), desiring more information (p < 0.001), smoking (p = 0.014), not engaging in physical activity in the low (p = 0.006) or high (p < 0.001) categories, having a younger mean age (p = 0.007), and taking two to three (p = 0.029) or four or more (p < 0.001) chronic treatments. Conclusion Self-reported adherence has good specificity but poor sensitivity. The associated profiles of the discrepancies were obtained to identify both good and poor adherence.

Objective: studies have been published in Europe comparing the mean macronutrient and micronutrient intake values of the general population with those of the vegan population, but none has been conducted in a country that mainly follows the Mediterranean diet. Therefore, the aim of this study was to carry out this comparison in Spain. Methods: a cross-sectional study of a sample of Spanish vegans was designed in 2015. To compare the distribution of nutrients with those of the general population, we used data from the Spanish Agency for Food Safety and Nutrition, which was considered to be normally distributed as it was a large population with biological parameters. All participants were asked about their dietary intake for the previous day (24 hour reminder) and the nutrients were calculated using specialized software. The distributions were compared using the Kolmogorov-Smirnov test. Results: The sample comprised 102 vegans, 67 of whom were women. The vegan population consumed more carbohydrates and fiber, less total fat (women only), fewer saturated fatty acids, and more polyunsaturated fatty acids. They had much lower cholesterol intake, lower calcium and iodine intake, higher iron and folic acid intake, and much lower intake of vitamins B12 and D. Conclusions: Spanish vegans had nutritional deficiencies compared to the general population and should therefore ensure their diet includes the necessary supplements., Antecedentes: se han publicado en Europa estudios que comparan los valores medios de ingesta de macronutrientes y micronutrientes de la población general con los de la población vegana, pero ninguno se ha llevado a cabo en un país que sigue principalmente la dieta mediterránea. Por lo tanto, el objetivo de este estudio fue llevar a cabo esta comparación en España. Métodos: se diseñó un estudio transversal de una muestra de veganos españoles en 2015. Para comparar la distribución de nutrientes con los de la población general, utilizamos datos de la Agencia Española de Seguridad Alimentaria y Nutrición, considerando dichos datos como una distribución normal de parámetros biológicos al constituir una gran muestra. A todos los participantes se les preguntó sobre su ingesta dietética en el día anterior y los nutrientes se calcularon utilizando un software especializado. Las distribuciones se compararon mediante la prueba de Kolmogorov-Smirnov. Resultados: La muestra comprendió 102 veganos, 67 de los cuales eran mujeres. La población vegana consumió más carbohidratos y fibra, menos grasa total (solo mujeres), menos ácidos grasos saturados y más ácidos grasos poliinsaturados. Tenían una ingesta mucho más baja de colesterol, una ingesta más baja de calcio y yodo, una mayor ingesta de hierro y ácido fólico, y una ingesta mucho más baja de vitaminas B12 y D. Conclusión: los veganos españoles tenían deficiencias nutricionales en comparación con la población general y, por lo tanto, deben asegurarse de que su dieta incluya los suplementos necesarios.

Introducción: Existen recomendaciones europeas de actividad física para la infancia. El principal objetivo de estudio era determinar los factores que podrían influir en el cumplimiento de las recomendaciones europeas de actividad física en la primera infancia. Métodos: Se incluyó a 136 niños (2-8 años), clasificados según su estado de peso medido con puntajes Z del IMC siguiendo los estándares de la Organización Mundial de la Salud. Se midió la actividad física durante 5 días consecutivos con acelerómetros y la ingesta diaria. Resultados: Una mayor actividad física se asoció con un menor estado de peso (B = −1,55; IC 95%: −2,02 a −1,08; p < 0,001), menor edad (B = −1,33; IC 95%: −1,72 a −0,93; p < 0,001) y mayor gasto energético (B = 0,02; IC 95%: 0,02 a 0,03; p < 0,001). El total de la muestra tuvo una actividad física ligera (media = 589 cpm/día). Los niños con sobrepeso y obesidad pasaron menos tiempo en actividad física moderada-vigorosa (p = 0,005) y más tiempo en actividad física sedentaria (p = 0,005) que los del grupo normopeso. Todos los grupos pasaron entre 90 y 130 min diarios en actividades sedentarias, con una media que supone un 15,5% del tiempo de actividad (eliminando las horas de sueño). El cumplimiento de las recomendaciones europeas depende del sexo (p = 0,010) y del estado de peso (p = 0,038). Conclusión: Los preescolares pasaron más de 100 min diarios en tiempo sedentario. Las recomendaciones europeas de actividad física moderada-vigorosa diarias se cumplieron por la mayoría de la muestra. Sin embargo, este cumplimiento dependía del sexo y del menor estado de peso., Introduction: There are established European guidelines for physical activity in childhood. The main goal of our study was to determine the factors that may influence compliance with European recommendations for physical activity in young children. Methods: We included 136 children (aged 2-8 years) classified by weight status, calculated based on the body mass index z-score using the growth standards of the World Health Organization. We measured physical activity over 5 consecutive days with accelerometers and recorded the food intake. Results: A greater level of physical activity was associated with a lower weight status category (B = −1.55; 95% CI: −2.02 to −1.08; P < .001), lower age (B = −1.33; 95% CI: −1.72 to −0.93; P < .001) and greater energy expenditure (B = 0.02; 95% CI: 0.02 to 0.03; P < .001). The overall physical activity in the sample was light (mean = 589 cpm/day). Children with overweight and obesity spent less time engaged in moderate to vigorous physical activity (P = .005) and more time engaged in sedentary activities (P = .005) compared to children with normal weight. All groups spent between 90 and 130 minutes a day in sedentary activities, with a mean time spent that amounted to 15.5% of their time (excluding time spent sleeping). The adherence to European recommendations varied in association with sex (P = .010) and weight status (P = .038). Conclusion: Young children spent more than 100 minutes a day engaged in sedentary activities. Most of the sample met the European recommendations for daily moderate to vigorous physical activity. However, the degree of adherence depended on sex and weight status.

Background. Polyphenol-rich olive extracts are non-toxic and have anti-inflammatory, neuroprotective and antiadipogenic effects in cell and animal models. Objective. To evaluate the potential influence of olive extracts on the mechanisms of digestion and absorption of polysaccharides and fats by quantifying amylase, glucose, phospholipase, and cholesterol in the medaka fish model. Material and methods. For each assay, six adult fish were placed in a tank with an extract (0.01% concentration), performing three replicates per extract. A control group with standard feeding was used. The same procedure was followed to study glucose, adding a polysaccharide-rich diet and a corresponding overfed control. The fish were maintained under these conditions for five days. Five olive extracts were used without attempting to purify the polyphenols due to possible synergistic effects. Total concentrations were between 2-116mg/g (mainly oleuropein and hydroxytyrosol). On completion, amylase, phospholipase A2, glucose and cholesterol were quantified in each group. All assays were conducted in triplicate. Enzyme activities were also studied in juveniles. Non-parametric tests were used to determine possible differences, considering p<0.05 to denote statistical significance. Results. Polyphenol extracts were not toxic at a concentration of 0.1%, ten times higher than the concentration used. An overall decrease in glucose levels was observed in fish overfed with carbohydrates with the addition of the extracts, but without returning to the levels in the control group with standard feeding (between 15-40% decrease). There was no impact on amylase in adults or juveniles, an overall but not significant decrease in cholesterol, and an overall increase in phospholipase in the juveniles. Conclusion. Olive extracts rich in polyphenols lower glucose levels in overfed fish., Antecedentes. Los extractos de aceitunas ricos en polifenoles no son tóxicos y tienen efectos antiinflamatorios, neuroprotectores y antiadipogénicos en modelos celulares y animales. Objetivo. Evaluar la influencia potencial de los extractos de aceituna en los mecanismos de digestión y absorción de polisacáridos y grasas mediante la cuantificación de amilasa, glucosa, fosfolipasa y colesterol en el modelo de pez medaka. Material y métodos. Para cada ensayo, se colocaron seis peces adultos en un tanque con un extracto (al 0,01%), realizando tres repeticiones por extracto. Se usó un grupo control con alimentación estándar. Se siguió el mismo procedimiento para estudiar la glucosa, agregando una dieta rica en polisacáridos y un control de sobrealimentados. Los peces se mantuvieron en estas condiciones durante cinco días. Se usaron cinco extractos del olivo sin intentar purificar los polifenoles debido a posibles efectos sinérgicos. Las concentraciones totales fueron entre 2-116 mg/g (principalmente oleuropeína e hidroxitirosol). Al finalizar, se cuantificaron amilasa, fosfolipasa A2, glucosa y colesterol en cada grupo. Todos los ensayos se realizaron por triplicado. Las actividades enzimáticas también se estudiaron en alevines. Se utilizaron pruebas no paramétricas para determinar posibles diferencias, considerando p <0.05 para significación estadística. Resultados. Los extractos de polifenoles no fueron tóxicos a una concentración de 0.1%, diez veces mayor que la concentración utilizada. Se observó una disminución general en los niveles de glucosa en peces sobrealimentados con carbohidratos con la adición de extractos, pero sin volver a los niveles del grupo control con alimentación estándar (disminución entre 15-40%). No hubo impacto sobre la amilasa en adultos o juveniles, se observó una disminución general pero no significativa del colesterol y un aumento general de la fosfolipasa en los juveniles. Conclusión. Los extractos de aceitunas ricos en polifenoles red

Objetivo. Evaluar la eficacia coadyuvante de una combinación de ingredientes cosméticos en forma de crema lipolítica con dieta hipocalórica y actividad física comparada con dieta hipocalórica y actividad física para el tratamiento del sobrepeso y la obesidad en pacientes. Material y métodos. Se realizó un estudio monocéntrico, abierto y aleatorizado de grupos paralelos de 102 pacientes que consultaron a un centro de nutrición médico-clínico para el tratamiento del sobrepeso y la obesidad. Los perímetros de altura, brazo, cintura, cadera y muslo y el análisis de la composición corporal segmentaria con un equipo de impedancia se estudiaron en pacientes de 18 a 99 años de ambos sexos con asistencia voluntaria y con presencia de sobrepeso u obesidad durante un período de 16 semanas consecutivas. Los datos se analizaron estadísticamente comparando los valores iniciales y finales de todos los valores en ambos grupos. La seguridad fue monitoreada por la incidencia de eventos adversos. Un valor de p<0,001 fue considerado como de significación estadística. Resultados. Del total de 102 pacientes, se aplicaron los criterios de inclusión y exclusión; se incluyeron y analizaron 45 y 47 casos, respectivamente. La edad oscila entre 39,16 y 42,09 años (p = 0,246); el peso inicial 85,9 kg vs 85,08 kg (p = 0,810); perímetros: cintura inicial de 100,4 cm frente a 99,7 cm (p = 0,826); brazo inicial de 32,9 cm vs 33,4 cm (p = 0,453); cadera inicial: 108,6cm vs 107,7 (p = 0,666). Peso final 82,6 kg vs 78,7 kg (p = 0,227); perímetros: cintura final de 94,9 cm frente a 90,9 cm (p = 0,144); brazo final de 31,8 cm frente a 31,4 cm (p = 0,453); Cadera final: 106,7 cm vs 102,1 (p = 0,074). No hubo ningún informe de efectos secundarios no deseados con el uso de crema lipolítica, presentando una buena aceptabilidad. Los pacientes con crema lipolítica como adyuvante en el tratamiento del sobrepeso u obesidad perdieron mayor IMC, mayor porcentaje de peso y mayor porcentaje de grasa (p<0,001). Conc, Objective. To evaluate the coadyouvant efficacy of a combination of cosmetics ingredients in the form of a lipolytic cream with hypocaloric diet and physical activity and compared with hypocaloric diet and physical activity for overweight and obesity treatment in patients. Material and methods. It was conducted a monocentric, open-label, randomized study of parallel groups of 102 patients that consulted in a medical-clinical nutrition center for overweight and obesity treatment. Height, arm, waist, hip and thigh perimeters and the analysis of segmental body composition with an impedance team were studied in patients between 18 and 99 years, of both sexes with voluntary attendance and with presence of overweight or obesity during a period of 16 consecutive weeks. The data were statistically analyzed by comparing the initial and final values of all the values in both groups. Safety was monitored by the incidence of adverse events. A value of p<0.001 was considered as statistical significance. Results. Of the total of 102 patients, the inclusion and exclusion criteria were applied; 45 and 47 cases are included and analyzed respectively. The age ranges between 39.16 vs 42.09 years (p = 0.246); initial weight 85.9 kg vs 85.08 kg (p = 0.810); perimeters: initial waist of 100.4cm vs 99.7cm (p = 0.826); initial arm of 32.9cm vs 33.4cm (p = 0.453); initial hip: 108.6cm vs 107.7 (p = 0.666). Final weight 82.6 kg vs 78.7 kg (p = 0.227); perimeters: final waist of 94.9 cm vs 90.9 cm (p = 0.144); final arm of 31.8 cm vs 31.4 cm (p = 0.453); final hip: 106.7 cm vs 102, 1 (p = 0.074). There was no report of unwanted side effects with the use of lipolytic cream, presented good acceptability. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater percentage of weight and greater percentage of fat (p <0.001). Conclusion. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater

Introducción. Sobrepeso y obesidad responden a factores socioeconómicos, culturales y familiares, pero no hay unanimidad en la influencia en niños del entorno rural-urbano sobre sus hábitos y consumo de alimentos. Por ello, se plantea como objetivo estudiar frecuencia y posible diferencia de consumo de alimentos según medio de residencia. Material y métodos. Estudio observacional, descriptivo y transversal en niños de 6º de primaria de una población urbana (n=111) y otra rural (n=58). Se obtuvieron variables antropométricas, hábitos nutricionales y frecuencia consumo de 24 grupos de alimentos. Se realizó análisis bivariante de todas las variables según entorno y de regresión logística ordinal, ajustando por sexo y edad. Los datos fueron anonimizados y se realizó con autorización del Comité Ético pertinente. Resultados. De 111, fueron niñas el 54,4% y edad media 10,9±0,5 años, sin diferencias significativas entre ambas poblaciones, así como con las variables antropométricas. En el análisis bivariante, solamente el consumo de bollería industrial es mayor en el entorno urbano (p=0,004), este dato se confirma mediante el análisis multivariante al ajustar por sexo y edad (OR=3,34; IC 95% 1,46-7,63; p=0,004), que también muestra significancia para menor consumo de pan blanco en el entorno urbano (OR=0,53; IC 95% 0,29-0,97; p=0,037). En relación a los hábitos alimentarios de desayuno y comida en comedor escolar, no se observa ninguna diferencia significativa entre ambos entornos. Conclusión. Los hábitos y consumo de alimentos es prácticamente idéntico en entorno urbano y rural en niños de sexto de primaria., Introduction. Overweight and obesity respond to socioeconomic, cultural and family factors, but there is no unanimity in the influence of rural-urban children on their habits and food consumption. For this reason, the objective is to study the frequency and possible difference of food consumption according to the residence environment. Material and methods. Observational, descriptive and cross-sectional study in children of 6th grade of an urban population (n=111) and another rural one (n=58). Anthropometric variables, nutritional habits and frequency of 24 food groups were obtained. Bivariate analysis of all variables according to environment and ordinal logistic regression was performed, adjusting by sex and age. The data was anonymised and carried out with the authorization of the pertinent Ethical Committee. Results. Of 111 childrens, 54.4% were girls and 10.9±0.5 years old mean age, without significant differences between both populations, as well as with anthropometric variables. In the bivariate analysis, only the consumption of industrial pastries is higher in the urban setting (p=0.004), this data is confirmed by the multivariate analysis when adjusting by sex and age (OR=3.34; 95% CI 1.46-7.63; p=0.004), which also shows significance for lower consumption of white bread in the urban environment (OR=0.53; 95% CI 0.29-0.97; p=0.037). In relation to the eating habits of breakfast and lunch in school cafeteria, no significant difference between both environments is observed. Conclusion. The habits and consumption of food is practically identical in urban and rural environment in children of sixth grade.

Aims. To assess the possible effect of polyphenol-rich olive extracts on lipid metabolism in medaka fish by quantifying the expression of lipogenic and lipolytic genes. Materials and methods. Adult medaka fish were maintained in tanks for five days with five extracts at 0.01% in water, causing obesity through a diet rich in carbohydrates, with a control group maintained in water with a normal diet. The extracts contained polyphenols ranging between 7 and 116 mg/g (oleuropein, hydroxytyrosol) with an antioxidant power of 2–13 mmol of 2,4,6-tri(2-pyridyl)-1,3,5-triazine/100 g. After five days, the fish were sacrificed and the hepatic mRNA and its complementary DNA were extracted by reverse transcription. Complementary DNAs were quantified for three lipolytic and three lipogenic genes by real-time PCR. The relative gene expression was calculated from the amplification curves in reference to the control group. Results. The expression of genes involved in lipolysis, including peroxisome proliferator-activated receptor-±, acyl-CoA oxidase 1, and carnitine palmitoyltransferase 1, were clearly decreased in fish subjected to an obesogenic diet, and this situation could not be reversed in fish maintained with polyphenol-rich extracts. In contrast, lipogenic fatty acid synthase, acetyl-CoA carboxylase 1, and sterol regulatory element-binding protein 1 genes increased considerably with the obesogenic diet and reverted to the normal state with the olive extracts. The effect was not dependent on the total polyphenol content, the specific oleuropein or hydroxytyrosol concentration, or the antioxidant power, suggesting a synergistic effect. Conclusion. Olive polyphenols, acting as anti-lipogenic agents, have a positive effect on lipid metabolism, but their mechanism in each gene is different according to the extract, which supports synergistic mechanisms with the different proportions of polyphenols and accompanying phytochemicals in each extract.

Background Maternal iodine deficiency is related to high neonatal thyroid-stimulating hormone (TSH) values, with the threshold of 5 mIU/L recommended as an indicator of iodine nutrition status. The objective of this study was to analyse possible risk factors for increased TSH that could distort its validity as a marker of iodine status. The clinical relevance of this research question is that if the factors associated with iodine deficiency are known, iodine supplementation can be introduced in risk groups, both during pregnancy and in newborns. Methods A case-control study was carried out in a sample of 46,622 newborns in 2002–2015 in Spain. Of these, 45,326 had a neonatal TSH value ≥5 mIU/L. The main variable was having TSH ≥5 mIU/L and the secondary variables were: sex, gestational age, day of sample extraction and maternal origin. Associated factors were analysed through a logistic regression model, calculating the odds ratio (OR). Results The factors associated with this outcome were: male sex (OR = 1.34, 95% CI: 1.20–1.50, p<0.001), originating from an Asian/Oceanic country (OR = 0.80, 95% CI: 0.54–1.20, p = 0.536) or Europe (OR = 0.80, 95% CI: 0.66–0.96, p = 0.285) (including Spain, OR = 1) [p<0.001 for America (OR = 0.54, 95% CI: 0.44–0.68) and p = 0.025 for Africa (OR = 0.78, 95% CI: 0.62–0.97)] and fewer days from birth to sampling (OR = 0.80, 95% CI: 0.77–0.82, p<0.001). Conclusions The risk of high neonatal TSH without congenital hypothyroidism is higher in males, decreases with a greater number of days from birth to extraction, and is dependent on maternal ethnicity but not on gestational age.

Purpose: In neonatal units, the use of peripheral venous catheters is a commonly used technique involving risks and local complications. Catheter duration and viability is limited and may involve multiple insertion attempts. Catheterization was considered successful when there were no local complications and the catheter was removed owing to completion of treatment. The aim of the study was to determine the optimal location and instruments to reduce the number of catheter insertion attempts and to increase time without complications. Design and methods: A cross-sectional descriptive study was undertaken to analyze all the catheters inserted in the neonatal intermediate care unit of Vinalopó University Hospital (Elche, Spain). Between 2013 and 2017 the following variables were collected: sex, age, gestational age, and venipuncture site, as well as catheter type, number of insertion attempts, duration and complications. Results: A total of 929 catheters were analyzed with a mean duration of 46.5 ± 33.9 h, and were removed upon completion of treatment (success 38.3%). The preferred site was the dorsal hand (48.2%) followed by the cubital fossa (20.1%). In both sites the success of the catheter and its duration was higher than the mean (42.4%; 43.9% and 49.4 ± 35.7; 50.3 ± 33.4 h respectively). The most frequent complications were extravasation (47.0%) and phlebitis (5.9%). Just one attempt was needed for 63.8% of cannulations of the dorsal hand, followed by 38.9% in the forearm. No significant differences were found in fixation type, sex, weight, gestational age or infusion type (continuous/intermittent). Conclusions: The success of the technique is low. The preferred insertion sites with fewer complications, longer duration and fewer attempts were the dorsal hand and cubital fossa. With fewer attempts required for cannulation, better results were achieved on the dorsal hand.