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28 results on '"Cortis, D."'

2. Cosmic Neutrino Background detection with PTOLEMY

Author

Rossi, N, Apponi, A, Betti, M, Borghesi, M, Castellano, O, Cavoto, G, Celasco, E, Chung, W, Cocco, A, Colijn, A, Cortis, D, D'Ambrosio, N, de Groot, N, el Morabit, S, Esposito, A, Farino, M, Faverzani, M, Ferri, E, Ficcadenti, L, Gariazzo, S, Garrone, H, Gatti, F, Giachero, A, Iwasaki, Y, Laubenstein, M, Manenti, L, Mangano, G, Marcucci, L, Mariani, C, Mead, J, Menichetti, G, Messina, M, Monticone, E, Naafs, M, Nucciotti, A, Pandolfi, F, Paoloni, D, Pepe, C, de los Heros, C, Pisanti, O, Pofi, F, Polosa, A, Puiu, A, Rago, I, Rajteri, M, Ruocco, A, Tan, A, Tozzini, V, Tully, C, van Rens, I, Virzi, F, Visser, G, Viviani, M, Zeitler, U, Zheliuk, O, Zimmer, F, Rossi N., Apponi A., Betti M. G., Borghesi M., Castellano O., Cavoto G., Celasco E., Chung W., Cocco A., Colijn A., Cortis D., D'Ambrosio N., de Groot N., el Morabit S., Esposito A., Farino M., Faverzani M., Ferri E., Ficcadenti L., Gariazzo S., Garrone H., Gatti F., Giachero A., Iwasaki Y., Laubenstein M., Manenti L., Mangano G., Marcucci L. E., Mariani C., Mead J., Menichetti G., Messina M., Monticone E., Naafs M., Nucciotti A., Pandolfi F., Paoloni D., Pepe C., de los Heros C. P., Pisanti O., Pofi F., Polosa A. D., Puiu A., Rago I., Rajteri M., Ruocco A., Tan A., Tozzini V., Tully C., van Rens I., Virzi F., Visser G., Viviani M., Zeitler U., Zheliuk O., Zimmer F., Rossi, N, Apponi, A, Betti, M, Borghesi, M, Castellano, O, Cavoto, G, Celasco, E, Chung, W, Cocco, A, Colijn, A, Cortis, D, D'Ambrosio, N, de Groot, N, el Morabit, S, Esposito, A, Farino, M, Faverzani, M, Ferri, E, Ficcadenti, L, Gariazzo, S, Garrone, H, Gatti, F, Giachero, A, Iwasaki, Y, Laubenstein, M, Manenti, L, Mangano, G, Marcucci, L, Mariani, C, Mead, J, Menichetti, G, Messina, M, Monticone, E, Naafs, M, Nucciotti, A, Pandolfi, F, Paoloni, D, Pepe, C, de los Heros, C, Pisanti, O, Pofi, F, Polosa, A, Puiu, A, Rago, I, Rajteri, M, Ruocco, A, Tan, A, Tozzini, V, Tully, C, van Rens, I, Virzi, F, Visser, G, Viviani, M, Zeitler, U, Zheliuk, O, Zimmer, F, Rossi N., Apponi A., Betti M. G., Borghesi M., Castellano O., Cavoto G., Celasco E., Chung W., Cocco A., Colijn A., Cortis D., D'Ambrosio N., de Groot N., el Morabit S., Esposito A., Farino M., Faverzani M., Ferri E., Ficcadenti L., Gariazzo S., Garrone H., Gatti F., Giachero A., Iwasaki Y., Laubenstein M., Manenti L., Mangano G., Marcucci L. E., Mariani C., Mead J., Menichetti G., Messina M., Monticone E., Naafs M., Nucciotti A., Pandolfi F., Paoloni D., Pepe C., de los Heros C. P., Pisanti O., Pofi F., Polosa A. D., Puiu A., Rago I., Rajteri M., Ruocco A., Tan A., Tozzini V., Tully C., van Rens I., Virzi F., Visser G., Viviani M., Zeitler U., Zheliuk O., and Zimmer F.

Abstract

The PTOLEMY experiment aims at detecting the cosmic neutrino background, generated approximately one second after the Big Bang, in accordance with Standard Cosmology. Given the extremely low energy of these neutrinos, reliable experimental detection can be accomplished through neutrino captures on beta-unstable nuclides, eliminating the need for a specific energy threshold. Tritium implanted on a carbon-based nanostructure emerges as a promising candidate among the various isotopes due to its favorable cross-section and low-endpoint energy. The Ptolemy collaboration plans to integrate a solid-state tritium source with a novel compact electromagnetic filter, based on the dynamic transverse momentum cancellation concept. This filter will be employed in conjunction with an event-based preliminary radio-frequency preselection. The measurement of neutrino mass and the exploration of light sterile neutrinos represent additional outcomes stemming from the Ptolemy experiment’s physics potential, even when utilizing smaller or intermediate-scale detectors. To finalize the conceptualization of the detector, a demonstrator prototype will be assembled and tested at LNGS in 2024. This prototype aims at addressing the challenging aspects of the Ptolemy experiment.

Published
2024

6. Metal additive manufacturing at INFN-LNGS laboratory: Facilities, testing and future capabilities.

Author

Orlandi, D. and Cortis, D.

Subjects
*COPPER alloys, *NUCLEAR research, *SELECTIVE laser melting, *REVERSE engineering, *STEEL alloys, *ALUMINUM alloys, *CELLULOSE nanocrystals
Abstract

INFN "Gran Sasso National Laboratory" (Laboratori Nazionali del Gran Sasso - LNGS) is the largest underground laboratory in the world devoted to neutrino and astroparticle physics. Internally, the Mechanics service is focused on design and manufacturing of complex devices for both nuclear and astroparticle physics research and industrial technology transfer. Among its activities there are: traditional and CNC machining, quality control, mechanical design, multi-physics simulations, reverse engineering, and Additive Manufacturing (AM) both for plastic and metallic materials. In the INFN context, it poses itself as a reference for Additive Manufacturing (AM), quality analysis and chemical characterization. Intense activities, often in collaboration with other international laboratories, universities, and industries, are ongoing in this field. The service is equipped with an L-PBF machine, based on the Selective Laser Melting (SLM) technology. Materials such as Copper (e.g., OFHC / 99.8%), Copper alloy (e.g., CuCrZr), Steel alloys (e.g., AISI 316L) and Aluminum alloys (e.g., SCALMALOY®) are currently used. [ABSTRACT FROM AUTHOR]

Published
2023
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7. The ASTAROTH project.

Author

D'Angelo, D., Zani, A., Alessandria, F., Andreani, A., Castoldi, A., Coelli, S., Cortis, D., Di Carlo, G., Frontini, L., Gallice, N., Guazzoni, C., Liberali, V., Monti, M., Orlandi, D., Sorbi, M., Stabile, A., and Statera, M.

Subjects
DARK matter, THRESHOLD energy, COPPER, PHOTOMULTIPLIERS, LOW temperatures, RESEARCH & development projects, SCINTILLATORS, SCINTILLATION counters
Abstract

The most discussed topic in direct searches for dark matter is arguably the verification of the DAMA claim. In fact, the observed annual modulation of the signal rate in an array of NaI(Tl) detectors can be interpreted as the awaited signature of dark matter interactions. Several experimental groups are currently engaged in the attempt to verify such a game-changing claim with the same target material. However, all present-day designs are based on a light readout via Photomultiplier Tubes, whose high noise makes it challenging to achieve a low background in the 1–6 keV energy region of the signal. Even harder would be to break below 1 keV energy threshold, where a large fraction of the signal potentially awaits to be uncovered. ASTAROTH is an R&D project to overcome these limitations by using Silicon Photomultiplier (SiPM) matrices to collect scintillation light from NaI(Tl). The all-active design based on cubic crystals is operating in the 87–150 K temperature range where SiPM noise can be even 100 lower than that of PMTs. The cryostat was developed following an innovative design and is based on a copper chamber immersed in a liquid-argon bath that can be instrumented as a veto detector. We have characterized separately the crystal and the SiPM response at low temperature, and we have proceeded to the first operation of a NaI(Tl) crystal read by SiPMs in cryogeny. [ABSTRACT FROM AUTHOR]

Published
2023
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9. The ASTAROTH project

Author

D’Angelo, D., primary, Zani, A., additional, Alessandria, F., additional, Andreani, A., additional, Castoldi, A., additional, Coelli, S., additional, Cortis, D., additional, Di Carlo, G., additional, Frontini, L., additional, Gallice, N., additional, Guazzoni, C., additional, Liberali, V., additional, Monti, M., additional, Orlandi, D., additional, Sorbi, M., additional, Stabile, A., additional, and Statera, M., additional

Published
2023
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11. Design and expected performances of the large acceptance calorimeter for the HERD space mission

Author

Pacini, L., Adriani, O., Bai, Y. -L., Bao, T. -W., Berti, E., Bottai, S., Cao, W. -W., Casaus, J., Cui, X. -Z., D’Alessandro, R., Formato, V., Gao, J. -R., Li, R., Liu, X., Lorusso, L., Lyu, L. -W., Marin, J., Martinez, G., Pizzolotto, C., Qin, J. -J., Quan, Z., Shi, D. -L., Starodubtsev, O., Tang, Z. -C., Tiberio, A., Vagelli, V., Velasco, M. A., Wang, B., Wang, Hongmei, R. -J., Z. -G., Xu, M., Yang, Y., Zhang, L., Zheng, J. -K., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Space experiments, Energy, Scintillating fiber, Performance, Monte Carlo methods, Measurements of, Space stations, Space missions, Cosmology, Cosmic rays, Intelligent systems, Scintillation counters, Silicon detectors, Charge detectors, Fiber trackers, Radiation detection, Read out systems, Calorimeters
Published
2022

12. Gamma-ray performance study of the HERD payload

Author

Adriani, O., Alemanno, F., Aloisio, R., Altomare, C., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, E., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Casaus, J., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, Y., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetano, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantaleo, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Performance, Cosmology, Gamma rays, Optical transfer function, Space stations, Dark matter searches, Detector geometry, Full simulations, Gamma-rays, Knee energy, Performance study, Radiation detection, Space astronomy, Cosmic rays
Published
2022

13. The High Energy cosmic-Radiation Detector (HERD) Trigger System

Author

Velasco, M. A., Bao, T., Berti, E., Bonvicini, V., Casaus, J., Giovacchini, F., Liu, X., Marco, R., Marín, J., Martínez, G., Mori, N., Oliva, A., Pacini, L., Quan, Z., Tang, Z., Xu, M., Zampa, G., Zampa, N., Adriani, O., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Gomez, N., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marrocchesi, R., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mussolin, L., Nicola, Mazziotta, Orlandi, M., Osteria, D., Panico, G., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Rappoldi, L., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zha, Q., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Cosmology, Gamma rays, Intelligent systems, Monte Carlo methods, Space stations, Tellurium compounds, Topology, Dark matter, Electron spectrum, Energy, Fundamental physics, Measurements of, Plastic scintillator detector, Precise measurements, Radiation detection, Space-borne, Trigger systems, Cosmic rays
Published
2022

14. The ASTAROTH Project: enhanced low-energy sensitivity to Dark Matter annual modulation

Author

Zani, A., primary, Alessandria, F., additional, Andreani, A., additional, Castoldi, A., additional, Coelli, S., additional, Cortis, D., additional, D’Angelo, D., additional, Carlo, G. Di, additional, Frontini, L., additional, Gallice, N., additional, Ghisetti, M., additional, Guazzoni, C., additional, Liberali, V., additional, Monti, M., additional, Orlandi, D., additional, Pasini, A., additional, Pedrini, D., additional, Prioli, M., additional, Sorbi, M., additional, Stabile, A., additional, and Statera, M., additional

Published
2021
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15. The ASTAROTH Project: enhanced low-energy sensitivity to Dark Matter annual modulation

Author

Zani, A., Alessandria, F., Andreani, A., Castoldi, A., Coelli, S., Cortis, D., D'Angelo, D., Di Carlo, G., Frontini, L., Gallice, N., Ghisetti, M., Guazzoni, C., Liberali, V., Monti, M., Orlandi, D., Pasini, A., Pedrini, D., Prioli, M., Sorbi, M., Stabile, A., and Statera, M.

Subjects
History, Computer Science Applications, Education
Abstract

ASTAROTH is a novel R&D project which aims at improving the physics reach of future direct dark matter detection experiments based on NaI(Tl) scintillating crystals. There is a strong need to test the long standing DAMA positive observation of an annual modulation that could be due to Dark Matter (DM), with the same target material and in a model independent way. ASTAROTH aim is the enhancement of the sensitivity to the annual modulation signal, compared with present technology, by lowering the detection energy threshold in order to observe sub-keV recoils for the first time. This can be achieved by reading the scintillation light from the NaI(Tl) crystals with arrays of Silicon PhotoMultipliers (SiPM), and placing the detectors in a cryogenic environment. SiPMs feature lower dark noise than Photomultiplier Tubes (PMTs) at T < 150 K and allow for higher light collection. The cooling medium is liquid Argon, as it is an excellent scintillator that can be instrumented to act as a veto against several backgrounds. Here we present the status of the ASTAROTH project, introducing the innovative design of the detector chamber that will be used for the demonstration of the technology. Then, we will show the preliminary results of our first ever measurements performed on a single NaI(Tl) crystal read out by one SiPM array in a cryogenic set-up cooled with liquid nitrogen.

Published
2021

16. Intravitreal aflibercept (A-IVI) for the treatment of neovascular age-related macular degeneration (nv-AMD): one year experience

Author

Evangelia Papavasileiou, Zygoura, V., Richardson, T., Cortis, D., Haralabos Eleftheriadis, and Timothy Jackson

Subjects
genetic structures, sense organs, eye diseases
Abstract

OBJECTIVE: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of naïve eyes with neovascular age-related macular degeneration (nv-AMD). SUBJECTS AND METHODS: This retrospective, one-center, non-comparative chart review included 26 treatment naïve eyes with nv-AMD of 26 patients (14 male) with a mean age of 80.5 (range 63-91) who had a complete follow-up of 14 months. The morphological analysis included spectral domain optical coherence tomography and fundus fluorescein angiography, while the functional assessment included logarithm of the minimum angle of resolution (LogMAR) best correct visual acuity (BCVA). The timing of the follow-up was: baseline, 3, 6, and 14 months. All patients received 8 A-IVI according to the protocol (first 3 consecutive monthly A-IVI, followed by bi-monthly retreatment for the first year, regardless of disease activity as per local guidelines). Statistical analysis was performed using ANOVA. Improvement of visual acuity more than 15 letters was considered as "improvement", less than 5 letters as "stable" and any letter loss as "worsening". RESULTS: Mean±standard deviation LogMAR visual acuity improved from 0.26±0.15 at presentation to 0.14±0.20 at the final follow-up of 14 months (P=0.02). BCVA was stable in 23.1%, improved in 61.5% (16 eyes) worsened in 15.4%. A mean pretreatment central macular thickness of 409μm reduced significantly to 229μm at month 14 (P

Published
2015

17. Overview of the diagnostics of the ELI-NP gamma beam system: Challenges for the electron-photon interaction point diagnostics

Author

Alesini, D., Bellaveglia, M., Buonomo, B., Cioeta, F., Cardelli, F., Anna Giribono, Di Pasquale, E., Di Pirro, G., Esposito, A., Falone, A., Franzini, G., Frasciello, O., Ghigo, A., Gallo, A., Guiducci, S., Incremona, S., Iungo, F., Lollo, V., Napolitano, A., Pellegrino, L., Piersanti, L., Pioli, S., Ricci, R., Rotundo, U., Sabbatini, L., Stella, A., Tomassini, S., Vaccarezza, C., Variola, A., Mostacci, A., Campogiani, G., Ficcadenti, L., Marongiu, M., Palumbo, L., Vannozzi, A., Bacci, A., Curatolo, C., Drebot, I., Petrillo, V., Rossetti, M., Rossi, A. R., Serafini, L., Cassou, K., Dupraz, K., Martens, A., Ndiaye, C. F., Williams, T., Zomer, F., Bliss, N., Hill, C., Cardarelli, P., Gambaccini, M., Cortis, D., Pettinacci, V., D Auria, G., Arpaia, P., Liccardo, A., Sabato, L., Albergo, S., Veltri, M., Alesini, D., Bellaveglia, M., Buonomo, B., Cioeta, F., Cardelli, F., Giribono, A., Di Pasquale, E., Di Pirro, G., Esposito, A., Falone, A., Franzini, G., Frasciello, O., Ghigo, A., Gallo, A., Guiducci, S., Incremona, S., Iungo, F., Lollo, V., Napolitano, A., Pellegrino, L., Piersanti, L., Pioli, S., Ricci, R., Rotundo, U., Sabbatini, L., Stella, A., Tomassini, S., Vaccarezza, C., Variola, A., Mostacci, A., Campogiani, G., Ficcadenti, L., Marongiu, M., Palumbo, L., Vannozzi, A., Bacci, A., Curatolo, C., Drebot, I., Petrillo, V., Rossetti, M., Rossi, A. R., Serafini, L., Cassou, K., Dupraz, K., Martens, A., Ndiaye, C. F., Williams, T., Zomer, F., Bliss, N., Hill, C., Cardarelli, P., Gambaccini, M., De Cortis, D., Pettinacci, V., D'Auria, G., Arpaia, P., Liccardo, A., Sabato, L., Albergo, S., and Veltri, M.

Subjects
beam diagnostics, beam diagnostics, compton source, compton source

18. Journalism

Author

Argyris, Chris, primary, MacDougall, Cortis D., additional, Fedler, Fred, additional, and Mills, Nicolaus, additional

Published
1974
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19. Journalism

Author

Chris Argyris, Cortis D. MacDougall, Fred Fedler, and Nicolaus Mills

Subjects
General Engineering
Published
1974
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20. Correlation between Axial Length and Presence of Diabetic Retinopathy.

Author

Papavasileiou, E., Velissaris, S., Garnavou-Xirou, C., Zygoura, V., Cortis, D., Sivaprasad, S., and Jackson, T.

Subjects
DIABETIC retinopathy, ETIOLOGY of diseases, PEOPLE with diabetes
Abstract

Introduction/Background: To describe the relationship between axial length (AL) and presence of diabetic retinopathy (DR) in diabetic patients. Methods: This retrospective, consecutive, comparative study, collected anonymized data between January 2010 and December 2015. We included all diabetic patients with (n = 396) or without DR (n = 272) who had biometry undertaken as a prelude to cataract surgery. Patients with incomplete data or ocular co-pathology were excluded. DR was diagnosed by clinical examination immediately prior to biometry. Outcome measurements were axial length and the presence and absence of DR. Results: The mean AL in the eyes with DR was 23.67 ± 1.26 mm, versus 23.52 ± 1.04 in the no DR group. In the DR group 3.79% (15 eyes) had an AL ≥26.00 mm versus 0.74% (2 eyes) in the no DR group. Conclusions: Greater AL may be associated with the presence of DR. Acknowledgements: None. [ABSTRACT FROM AUTHOR]

Published
2016

21. Correlation between Axial Length and Presence of Age-Related Macular Degeneration.

Author

Gkika, T., Papavasileiou, E., Garnavou-Xirou, C., Velissaris, S., Zygoura, V., Cortis, D., Sivaprasad, S., and Jackson, T.

Subjects
AGE factors in retinal degeneration, DISEASE progression, EYE diseases, PATIENTS
Abstract

Introduction/Background: To describe the relationship between axial length (AL) with progression of age-related macular degeneration (AMD). Methods: This retrospective, consecutive, comparative study, collected anonymized data between January 2010 and December 2015. We included patients with AMD who had AL measured as a prelude to cataract surgery. We excluded those with ocular copathology, incomplete data or choroidal neovascularization (CNV) secondary to pathologic myopia, retinal angiomatous proliferation and idiopathic polypoidal choroidal vasculopathy. AMD was diagnosed by clinical examination prior to biometry. Outcome measures were AL and AMD severity and type. Results: Of 99 eyes 49 had dry AMD and 50 had wet AMD. The mean (± standard deviation) AL of 43 eyes with only macular dru sen was 23.19 ± 0.84 mm, versus 23.24 ± 1.05 in 6 eyes with geographic atrophy, 23.43 ± 1.25 in 39 eyes with wet AMD and 23.36 ± 1.36 in 11 eyes with disciform scarring. Of the wet AMD group only 4% (2 of 50 eyes) had an AL ≥26.00 mm. Conclusions: AL was not found to be associated with the severity of AMD. Acknowledgements: None. [ABSTRACT FROM AUTHOR]

Published
2016

23. Experimental Data Collection of Surface Quality Analysis of CuCrZr Specimens Manufactured with SLM Technology: Analysis of the Effects of Process Parameters.

Author

Caravella I, Cortis D, Di Angelo L, and Orlandi D

Abstract

Selective laser melting (SLM) is the most widely used laser powder-bed fusion (L-PBF) technology for the additive manufacturing (AM) of parts from metallic powders. The surface quality of the SLM parts is highly dependent on many factors and process parameters. These factors include the powder grain size, the layer thickness, and the building angle. This paper conducted an experimental analysis of the effects of SLM process parameters on the surface quality of CuCrZr cubic specimens. Thanks to its excellent thermal and mechanical properties, CrCrZr has become one of the most widely used materials in SLM technology. The specimens have been produced with different combinations of layer thickness, laser patterns, building angles, and scanning speed, keeping the energy density constant. The results show how different combinations of parameters affect the surface quality macroscopically (i.e., layer thickness, building angle, and scanning speed); in contrast, other parameters (i.e., laser pattern) do not seem to have any contributions. By varying these parameters within typical ranges of the AM machine used, variations in surface quality can be achieved from 10.4 µm up to 40.8 µm. These results represent an important basis for developing research activities that will further focus on implementing a mathematical/experimental model to help designers optimize the surface quality during the AM pre-processing phase.

Published
2022
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24. Back to basics: measuring the impact of interventions to limit the spread of COVID-19 in Europe.

Author

Cortis D and Vella King F

Abstract

Background: Following the emergence of the COVID-19 pandemic in Europe at the start of 2020, most countries had implemented various measures in an attempt to control the spread of the virus. This study analyses the main non-pharmaceutical interventions and their impact on the rate by which cumulative cases and deaths were growing in Europe during the first wave of this pandemic., Methods: The interventions analysed are the school closures, restrictions on travel, cancellation of events, restrictions on gatherings, partial and full lockdowns. Data was collected on the implementation date of these interventions, and the number of daily cases and deaths during the first wave of the pandemic for every country and territory geographically located in Europe. The study uses growth rates to calculate the increase in cumulative cases and deaths in Europe before, during, and after these interventions were implemented., Results: The results show that decisions to close schools, cancel events, and restrict travel were taken during the same time period, whereas the decisions for the other interventions were taken when the growth rates were similar. The most effective interventions at lowering the rate by which cumulative cases were increasing were the travel restrictions, school closures, and the partial lockdown, while most effective against cumulative deaths were the partial lockdown, travel restrictions, and full lockdown., Conclusion: All the interventions reduced the rate by which cumulative cases and deaths were increasing with the partial lockdowns being the most effective from the other interventions, during the first wave of the pandemic in Europe., (© 2022. The Author(s).)

Published
2022
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25. On Determining the Age Distribution of COVID-19 Pandemic.

Author

Cortis D

Subjects
Adolescent, Adult, Aged, Child, Child, Preschool, China epidemiology, Female, Humans, Middle Aged, Republic of Korea epidemiology, Risk Factors, Young Adult, Age Distribution, COVID-19 epidemiology, COVID-19 mortality
Abstract

Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged sword as this comment shows higher morbidity rates in elderly as well. This is shown by comparing the age distribution of cases in China and South Korea to the relative populations. In every case, the relative number of elderly contracting the virus is far higher than the proportion of elderly in the population. This is unlike past pandemics and shows that aging populations are at an even higher risk than the perceived age dependent rates may imply., (Copyright © 2020 Cortis.)

Published
2020
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26. Real-world treatment of diabetic macular oedema: a comparison of combined ranibizumab plus macular LASER with macular LASER monotherapy.

Author

Zygoura V, Papavasileiou E, Vavvas DG, Cortis D, Eleftheriadis H, and Jackson TL

Abstract

Objective: To study real world outcomes of ranibizumab (Lucentis) intravitreal injection in diabetic macular oedema (DMO)., Subjects and Methods: We included 100 patients with DMO. Those who had optical coherence tomography central retinal thickness (CRT) of 400μm or more (Group 1) underwent combination treatment with ranibizumab and macular LASER, while those with CRT less than 400μm (Group 2) had LASER monotherapy. The primary outcome measure was change in best corrected visual acuity (BCVA) from baseline. Secondary outcomes were change of CRT from baseline, the number of intravitreal injections in group one during the first and second year of follow-up and the proportion of LASER sessions in both groups at 2 years follow-up. Patients' lipid profile was compared to the presence and extent of macular hard exudates, quantified using masked readers and image analysis software., Results: Group 1 showed better outcomes in terms of BCVA and CRT compared to Group 2 during the two-year follow-up period. The mean number of ranibizumab intravitreal injections in Group 1 was reduced from 3.86 (standard deviation±1.37) in the first year to 2.02 in the second year. At 2 years, Group 1 had a higher proportion of individuals that had undergone 3 macular LASER treatments (4% Group 1, 28% Group 2). The presence of hard exudates was associated with higher total cholesterol (P=0.004 and P=0.041 group 1 and 2 respectively) and with higher low density lipoprotein (LDL) cholesterol (P=0.01 and P=0.045 respectively). The size of hard exudates was associated with higher total cholesterol (P=0.02 and P=0.03 respectively) and with higher LDL cholesterol (P=0.003 and P=0.01 respectively). Neither high density lipoprotein (HDL) cholesterol, nor triglycerides were related to the presence or size of hard exudates. No serious adverse events were attributed to either LASER or ranibizumab., Conclusions: Combination treatment of intravitreal ranibizumab injections and macular LASER appears safe and effective over two years. The need for injection declines over time. There is an association between higher levels of serum total and LDL cholesterol and the presence and the extent of hard exudates.

Published
2015

27. Intravitreal aflibercept (A-IVI) for the treatment of neovascular age-related macular degeneration (nv-AMD): one year experience.

Author

Papavasileiou E, Zygoura V, Richardson T, Cortis D, Eleftheriadis H, and Jackson TL

Abstract

Objective: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of naïve eyes with neovascular age-related macular degeneration (nv-AMD)., Subjects and Methods: This retrospective, one-center, non-comparative chart review included 26 treatment naïve eyes with nv-AMD of 26 patients (14 male) with a mean age of 80.5 (range 63-91) who had a complete follow-up of 14 months. The morphological analysis included spectral domain optical coherence tomography and fundus fluorescein angiography, while the functional assessment included logarithm of the minimum angle of resolution (LogMAR) best correct visual acuity (BCVA). The timing of the follow-up was: baseline, 3, 6, and 14 months. All patients received 8 A-IVI according to the protocol (first 3 consecutive monthly A-IVI, followed by bi-monthly retreatment for the first year, regardless of disease activity as per local guidelines). Statistical analysis was performed using ANOVA. Improvement of visual acuity more than 15 letters was considered as "improvement", less than 5 letters as "stable" and any letter loss as "worsening"., Results: Mean±standard deviation LogMAR visual acuity improved from 0.26±0.15 at presentation to 0.14±0.20 at the final follow-up of 14 months (P=0.02). BCVA was stable in 23.1%, improved in 61.5% (16 eyes) worsened in 15.4%. A mean pretreatment central macular thickness of 409μm reduced significantly to 229μm at month 14 (P<0.02). The OCT of eyes with worsened BCVA showed resolution of retinal fluid but presence of subretinal fibrosis. No adverse events were attributed to aflibercept., Conclusions: Patients who had a worsening in visual acuity were found to have longer duration of symptoms prior to treatment and presence of geographic atrophy, and/or subretinal haemorrhage and/or subretinal fibrosis at baseline. From our experience, with 14 months follow-up, A-IVI is an effective treatment for treatment naïve patients with nv-AMD. Our real world results were similar to pivotal trials.

Published
2015

28. Phacoemulsification surgery in eyes with neovascular age-related macular degeneration.

Author

Grixti A, Papavasileiou E, Cortis D, Kumar BV, and Prasad S

Abstract

Purpose. To evaluate the visual outcomes and effect of phacoemulsification surgery on the progression of neovascular age-related macular degeneration (AMD). Methods. Retrospective, noncomparative, and interventional case series. Thirty eyes from 29 subjects with neovascular AMD treated with intravitreal antivascular endothelial growth factor (VEGF) injections who underwent phacoemulsification and had a postsurgery follow-up of 6 months were included. LogMAR best corrected visual acuity (BCVA) was assessed preoperatively; 1 month, 3 months, and 6 months postoperatively; and finally at the last visit. The frequency of anti-VEGF therapy, calculated as the number of intravitreal injections per month, and central macular thickness (CMT) before and after cataract surgery were determined. Results. Median (range) logMAR BCVA was 0.69 (0.16 to 1.32) preoperatively; 0.55 (-0.04 to 1.32) at 1 month, 0.52 (-0.1 to 1.32) at 3 months, and 0.50 (0.0 to 1.32) at 6 months postoperatively; and 0.6 (0.0 to 1.4) at final visit (P = 0.0011). There was no difference in the frequency of anti-VEGF injections between the immediate 6 months before and after phacoemulsification, which was equal to 0.1667 injections per month (P = 0.6377). Median CMT measured 203  μ m preoperatively, which temporarily increased to 238  μ m at 1 month after surgery (P = 0.0093) and then spontaneously returned to baseline, measuring 212.5  μ m at 3 months postoperatively (P = 0.3811). Conclusion. Phacoemulsification surgery significantly improved vision in patients with neovascular AMD, with no increased need for anti-VEGF injections to keep the macula dry postoperatively.

Published
2014
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