1. Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of Rinorea oblongifolia C.H. Wright (Violaceae).
- Author
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Munvera, Aristide Mfifen, Ngenge, Tamfu Alfred, Ouahouo, Blandine Marlyse Wache, Kucukaydin, Selcuk, Nyemb, Jean Noel, Mafo, Marcelle Aude Fokam, Tchapo, Emar Carlain Djappa, Mkounga, Pierre, and Nkengfack, Augustin Ephrem
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PHENOL oxidase ,UREASE ,ACETYLCHOLINESTERASE ,VIOLACEAE ,FRUIT ,COUMARINS ,PHENOLS ,ACID derivatives - Abstract
From Rinorea oblongifolia fruits, 3-Nor-4b-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), new derivatives alongside, 28-hydroxyfriedelan-3-one (2), friedelin (3), 3,3',4,4',5'-pentamethylcoruleoellagic acid (5), hexamethylcoruleoellagic acid (6), 3',4,4',5,5'-pentamethylcoruleoellagic acid (7), and fatty compounds 8-11 were isolated and characterized using HRESIMS, EIMS, 1D and 2D NMR. In vitro enzyme inhibition of compounds 1, 2, 4, 5, 6 and 7 were evaluated on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), a-glucosidase, urease and tyrosinase. Against AChE and BChE, the phenolic compounds 4, 5, 6, and 7 had good activity probably due to the phenolic nature and methoxy substituents. Compounds 4, 5, 6 and 7 exhibited good a-glucosidase inhibition especially compound 4 whose IC
50 = 42.45 ± 0.46 mg/mL was close that of acarbose (IC50 = 20.52 ± 0.84 mg/mL) standard drug. Urease and tyrosinase were appreciably inhibited by the compounds. Overall results of enzyme inhibitory assays indicate Rinorea oblongifolia, fruits and its constituents as potential remedy for enzymatic disorders. [ABSTRACT FROM AUTHOR]- Published
- 2023
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