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Climate change, specifically rising temperatures and increased frequency of droughts will increase the level of exposure of organisms to chemical pollution. Notably, the impact of increased frequency and duration of drought events and subsequent dehydration on pesticide toxicity remains largely unknown. We evaluated the combined effects of exposure to the pesticide Chlorpyrifos (CPF) and water restriction (WR) on the enzymatic activities of three plasma esterases (acetylcholinesterase, butyrylcholinesterase and carboxylesterase), basal metabolic rate (BMR), leukocyte profile (proportion of heterophils to lymphocytes; H:L ratio), and bactericidal capacity of plasma in the rufous-collared sparrow (Zonotrichia capensis), a common passerine bird in Chile. The activity of the enzyme carboxylesterase decreased in birds exposed only to CPF and birds exposed to both the CPF and WR. In the group exposed to both stressors, the butyrylcholinesterase activity was also reduced. The BMR exhibited an increase in both groups exposed to CPF, with a higher rise observed in the group exposed to both CPF and WR, while the group subjected to WR showed no change. The bactericidal capacity of the plasma decreased significantly in birds exposed to CPF and in those exposed to both the pesticide and WR, while a marginal effect was observed in the group only subjected to WR. The H:L ratio increased in all groups, with the most pronounced effect in birds exposed to both stressors. These results suggest a shift in the energy budget of Z. capensis, favoring the detoxification of the pesticide through esterase activities, at the expense of reduced immunocompetence., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)