30,563 results on '"Cosentino, A"'
Search Results
2. Neutron capture measurements for s-process nucleosynthesis; A review about CERN n_TOF developments and contributions
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Domingo-Pardo, C., Aberle, O., Alcayne, V., Alpar, G., Halabi, M. Al, Amaducci, S., Babiano, V., Bacak, M., Balibrea-Correa, J., Bartolomé, J., Bernardes, A. P., Gameiro, B. Bernardino, Berthoumieux, E., Beyer, R., Birch, M., Boromiza, M., Bosnar, D., Brusasco, B., Caamaño, M., Cahuzac, A., Calviño, F., Calviani, M., Cano-Ott, D., Casanovas, A., Castelluccio, D. M., Catlett, D., Cerutti, F., Cescutti, G., Chiaveri, E., Claps, G., Colombetti, P., Colonna, N., Camprini, P. Console, Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., D'Ottavi, A., Rosales, G. de la Fuente, Dellmann, S. F., Diakaki, M., Di Castro, M., Di Chicco, A., Dietz, M., Dupont, E., Durán, I., Eleme, Z., Eslami, M., Fargier, S., Fernández-Domínguez, B., Finocchiaro, P., Flanagan, W., Furman, V., Gandhi, A., García-Infantes, F., Gawlik-Ramiega, A., Gervino, G., Gilardoni, S., González-Romero, E., Goula, S., Griesmayer, E., Guerrero, C., Gunsing, F., Gustavino, C., Heyse, J., Hillman, W., Jenkins, D. G., Jericha, E., Junghans, A., Kadi, Y., Kaperoni, K., Kelly, I., Kokkoris, M., Kopatch, Y., Krtička, M., Kyritsis, N., Lederer-Woods, C., Lerendegui-Marco, J., Manna, A., Martínez, T., Martínez-Cañada, M., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Moldenhauer, J., Mucciola, R., González, E. Musacchio, Musumarra, A., Negret, A., Odusina, E., Papanikolaou, D., Patronis, N., Pavón-Rodríguez, J. A., Pellegriti, M. G., Pérez-Maroto, P., Fiol, A. Pérez de Rada, Perfetto, G., Perkowski, J., Petrone, C., Pieretti, N., Piersanti, L., Pirovano, E., Porras, I., Praena, J., Quesada, J. M., Reifarth, R., Rochman, D., Romanets, Y., Rooney, A., Rovira, G., Rubbia, C., Sánchez-Caballero, A., Sahoo, R. N., Scarpa, D., Schillebeeckx, P., Smith, A. G., Sosnin, N. V., Spelta, M., Stamati, M. E., Stasiak, K., Tagliente, G., Tarifeño-Saldivia, A., Tarrío, D., Torres-Sánchez, P., Tosi, S., Tsiledakis, G., Valenta, S., Vaz, P., Vecchio, G., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, A., Weiss, C., Woods, P. J., Wright, T., Wu, R., Žugec, P., and Collaboration, The n\_TOF
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Nuclear Experiment ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
This article presents a review about the main CERN n\_TOF contributions to the field of neutron-capture experiments of interest for $s$-process nucleosynthesis studies over the last 25 years, with special focus on the measurement of radioactive isotopes. A few recent capture experiments on stable isotopes of astrophysical interest are also discussed. Results on $s$-process branching nuclei are appropriate to illustrate how advances in detection systems and upgrades in the facility have enabled increasingly challenging experiments and, as a consequence, have led to a better understanding and modeling of the $s$-process mechanism of nucleosynthesis. New endeavors combining radioactive-ion beams from ISOLDE for the production of radioisotopically pure samples for activation experiments at the new NEAR facility at n\_TOF are briefly discussed. On the basis of these new exciting results, also current limitations of state-of-the-art TOF and activation techniques will be depicted, thereby showing the pressing need for further upgrades and enhancements on both facilities and detection systems. A brief account of the potential technique based on inverse kinematics for direct neutron-capture measurements is also presented., Comment: submitted to Eur. Phys. Jour. Topical Collection
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- 2025
3. Long-rising Type II supernovae resembling supernova 1987A -- II. A new analytical model to describe these events
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Pumo, M. L. and Cosentino, S. P.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
With the aim of improving our knowledge on supernova (SN) 1987A-like objects and, more in general, on H-rich SNe, we have developed a new analytic model to describe their post-explosive evolution. The distinctive features of this model are the possibility to evaluate the emitted luminosity and the SN expansion velocity, taking into account the recombination of the ejected material, the heating effects due to the \chem{56}{Ni} decay in the computation of the recombination front position, and the presence of an outer thin shell not-homologously expanding. In this paper, we present the model and a comparison with observations of SN 1987A, showing that its bolometric light curve and expansion velocity are accurately reproduced by the model. We also investigate the modeling degeneration problem in H-rich SNe and the possibility to ``standardize'' the subgroup of SN 1987A-like objects. Moreover we present new Ni-dependent relationships, based on our model, which link some features of the bolometric light curve of 1987A-like SNe (namely, the peak luminosity and its width) with the main physical properties of their progenitor at the explosion (i.e.~the ejected mass, the explosion energy, the progenitor radius at the explosion, and the amount of \chem{56}{Ni} present in the ejecta), showing that such relations are in excellent agreement with observations of real SNe. From our model, we also deduce new scaling relations which may be used for estimating the main SN progenitor's physical properties at the explosion, once only the photometric behaviour of the SN 1987A-like object is known., Comment: 21 pages, 13 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal
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- 2025
4. Novel Conditions for the Finite-Region Stability of 2D-Systems with Application to Iterative Learning Control
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Liang, Chao, Cosentino, Carlo, Merola, Alessio, Romano, Maria, and Amato, Francesco
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Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
Some recent papers have extended the concept of finite-time stability (FTS) to the context of 2D linear systems, where it has been referred to as finite-region stability (FRS). FRS methodologies make even more sense than the classical FTS approach developed for 1D-systems, since, typically, at least one of the state variables of 2D-systems is a space coordinate, rather than a time variable. Since space coordinates clearly belong to finite intervals, FRS techniques are much more effective than the classical Lyapunov approach, which looks to the asymptotic behavior of the system over an infinite interval. To this regard, the novel contribution of this paper goes in several directions. First, we provide a novel sufficient condition for the FRS of linear time-varying (LTV) discrete-time 2D-systems, which turns out to be less conservative than those ones provided in the existing literature. Then, an interesting application of FRS to the context of iterative learning control (ILC) is investigated, by exploiting the previously developed theory. In particular, a new procedure is proposed so that the tracking errors of the ILC law converges within the desired bound in a finite number of iterations. Finally, a sufficient condition to solve the finite-region stabilization problem is proposed. All the results provided in the paper lead to optimization problems constrained by linear matrix inequalities (LMIs), that can be solved via widely available software. Numerical examples illustrate and validate the effectiveness of the proposed technique.
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- 2024
5. The SOFIA Massive (SOMA) Star Formation Survey. V. Clustered Protostars
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Telkamp, Zoie, Fedriani, Ruben, Tan, Jonathan C., Law, Chi-Yan, Zhang, Yichen, Plunkett, Adele, Crowe, Samuel, Yang, Yao-Lun, De Buizer, James M., Beltran, Maria T., Bonfand, Melisse, Boyden, Ryan, Cosentino, Giuliana, Gorai, Prasanta, Liu, Mengyao, Rosero, Viviana, Taniguchi, Kotomi, and Tanaka, Kei E. I.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present $\sim8-40\,\mu$m SOFIA-FORCAST images of seven regions of ``clustered" star formation as part of the SOFIA Massive (SOMA) Star Formation Survey. We identify a total of 34 protostar candidates and build their spectral energy distributions (SEDs). We fit these SEDs with a grid of radiative transfer models based on the Turbulent Core Accretion (TCA) theory to derive key protostellar properties, including initial core mass, $M_c$, clump environment mass surface density, $\Sigma_{\rm cl}$, and current protostellar mass, $m_*$. We also carry out empirical graybody (GB) estimation of $\Sigma_{\rm cl}$, which allows a case of restricted SED fitting within the TCA model grid. We also release version 2.0 of the open-source Python package \emph{sedcreator}, designed to automate the aperture photometry and SED building and fitting process for sources in clustered environments, where flux contamination from close neighbors typically complicates the process. Using these updated methods, SED fitting yields values of $M_c\sim30-200\:M_{\odot}$, $\Sigma_{\text{cl,SED}}\sim0.1-3\:{\rm{g\:cm}}^{-2}$, and $m_*\sim4-50\:M_{\odot}$. The graybody fitting yields smaller values of $\Sigma_{\text{cl,GB}}\lesssim1\:{\rm{g\:cm}}^{-2}$. From these results, we do not find evidence for a critical $\Sigma_{\rm{cl}}$ needed to form massive ($\gtrsim 8\:M_\odot$) stars. However, we do find tentative evidence for a dearth of the most massive ($m_*\gtrsim30\:M_\odot$) protostars in the clustered regions suggesting a potential impact of environment on the stellar initial mass function., Comment: Submitted to ApJ, comments welcome
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- 2024
6. A joint effort to discover and characterize two resonant mini Neptunes around TOI-1803 with TESS, HARPS-N and CHEOPS
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Zingales, T., Malavolta, L., Borsato, L., Turrini, D., Bonfanti, A., Polychroni, D., Mantovan, G., Nardiello, D., Nascimbeni, V., Lanza, A. F., Bekkelien, A., Sozzetti, A., Broeg, C., Naponiello, L., Lendl, M., Bonomo, A. S., Simon, A. E., Desidera, S., Piotto, G., Mancini, L., Hooton, M. J., Bignamini, A., Egger, J. A., Maggio, A., Alibert, Y., Locci, D., Delrez, L., Biassoni, F., Fossati, L., Cabona, L., Lacedelli, G., Carleo, I., Leonardi, P., Andreuzzi, G., Brandeker, A., Cosentino, R., Correia, A. C. M., Claudi, R., Alonso, R., Damasso, M., Wilson, T. G., Bàrczy, T., Pinamonti, M., Baker, D., Barkaoui, K., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, T., Beichman, C., Benz, W., Bieryla, A., Billot, N., Bosch-Cabot, P., Bouma, L. G., Ciardi, D. R., Cameron, A. Collier, Collins, K. A., Crossfield, Ian J. M., Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. O., Derekas, A., Dragomir, D., Edwards, B., Ehrenreich, D., Erikson, A., Falk, B., Fortier, A., Fridlund, M., Fukui, A., Gandolfi, D., Gazeas, K., Gillon, M., Gonzales, E., Gudel, M., Guerra, P., Guunther, M. N., Heitzmann, A., Helling, Ch., Howell, S. B., Isaak, K. G., Jenkins, J., Kiss, L. L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Magrin, D., Matson, R., Matthews, E. C., Maxted, P. F. L., McDermott, S., Munari, M., Mordasini, C., Narita, N., Olofsson, G., Ottensamer, R., Pagano, I., Pallè, E., Peter, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Salmon, S., Santos, N. C., Scandariato, G., Seager, S., Sègransan, D., Smith, A. M. S., Schlieder, J., Schwarz, R. P., Shporer, A., Sousa, S. G., Stalport, M., Steinberger, M., Sulis, S., Szabò, Gy. M., Twicken, J. D., Udry, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., and Winn, J. N.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the discovery of two mini Neptunes near a 2:1 orbital resonance configuration orbiting the K0 star TOI-1803. We describe their orbital architecture in detail and suggest some possible formation and evolution scenarios. Using CHEOPS, TESS, and HARPS-N datasets we can estimate the radius and the mass of both planets. We used a multidimensional Gaussian Process with a quasi-periodic kernel to disentangle the planetary components from the stellar activity in the HARPS-N dataset. We performed dynamical modeling to explain the orbital configuration and performed planetary formation and evolution simulations. For the least dense planet, we define possible atmospheric characterization scenarios with simulated JWST observations. TOI-1803 b and TOI-1803 c have orbital periods of $\sim$6.3 and $\sim$12.9 days, respectively, residing in close proximity to a 2:1 orbital resonance. Ground-based photometric follow-up observations revealed significant transit timing variations (TTV) with an amplitude of $\sim$10 min and $\sim$40 min, respectively, for planet -b and -c. With the masses computed from the radial velocities data set, we obtained a density of (0.39$\pm$0.10) $\rho_{earth}$ and (0.076$\pm$0.038) $\rho_{earth}$ for planet -b and -c, respectively. TOI-1803 c is among the least dense mini Neptunes currently known, and due to its inflated atmosphere, it is a suitable target for transmission spectroscopy with JWST. We report the discovery of two mini Neptunes close to a 2:1 orbital resonance. The detection of significant TTVs from ground-based photometry opens scenarios for a more precise mass determination. TOI-1803 c is one of the least dense mini Neptune known so far, and it is of great interest among the scientific community since it could constrain our formation scenarios., Comment: 26 Pages, 21 Figures Accepted for Publication in Astronomy & Astrophysics
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- 2024
7. The GAPS programme at TNG LXVI. A homogeneous search for Na i and its possible variability in ten gas giant exoplanets
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Sicilia, D., Malavolta, L., Scandariato, G., Fossati, L., Lanza, A. F., Bonomo, A. S., Borsa, F., Guilluy, G., Nascimbeni, V., Pino, L., Biassoni, F., D'Arpa, M. C., Pagano, I., Sozzetti, A., Stangret, M., Cosentino, R., Giacobbe, P., Lodi, M., Maldonado, J., Nardiello, D., and Pedani, M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The neutral sodium resonance doublet (Na i D) has been detected in the upper atmosphere of several close-in gas giants, through high-resolution transmission spectroscopy. We aim to investigate whether its variability is linked to the planets' properties, the data quality, or the accuracy of the system parameters used. Using the public code SLOPpy, we extracted the transmission spectrum in the Na i D region of ten gas giants for which a large number of HARPS-N observations are available. We modelled the absorption signals found, performing an MCMC analysis, and converted the measured absorption depth to the corresponding atmospheric height over which most sodium absorption occurs. While two targets (GJ 436 b and KELT-7 b) show no Na i D feature, we found variability in the transmission spectrum of the other targets. Three of them (HD 209458 b, WASP-80 b, and WASP-127 b) present absorption on only some nights, while in the other five targets (HD 189733 b, KELT-9 b, KELT-20 b, WASP-69 b, and WASP-76 b), a significant absorption signal is present on most of the nights analysed. Except for WASP-69 b, the measured absorption depths lead to a ratio of the two Na I D depths that is compatible with or slightly larger than one. As was expected from literature, the relative atmospheric height follows an empirical exponential trend as a function of a scaled product of the planet's equilibrium temperature and surface gravity. We confirm the sodium detection on HD 189733 b, KELT-9 b, KELT-20 b, WASP-69 b, and WASP-76 b. The signal detected in WASP-127 b requires further observations for definitive confirmation. We exclude a planetary origin for the signals found on HD 209458 b and WASP-80 b. The sodium absorption variability does not appear to be related to planetary properties, but rather to data quality, sub-optimal data treatment, or stellar activity., Comment: Accepted for publication in Astronomy & Astrophysics on 26 November 2024. Additional material (Figures B.1-B.3 and Tables B.1-B.9) are available on Zenodo
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- 2024
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8. Radiative neutron capture cross section of $^{242}$Pu measured at n_TOF-EAR1 in the unresolved resonance region up to 600 keV
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Lerendegui-Marco, J., Guerrero, C., Mendoza, E., Quesada, J. M., Eberhardt, K., Junghans, A. R., Alcayne, V., Babiano, V., Aberle, O., Andrzejewski, J., Audouin, L., Becares, V., Bacak, M., Balibrea-Correa, J., Barbagallo, M., Barros, S., Becvar, F., Beinrucker, C., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Damone, L. A., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Furman, V., Göbel, K., García, A. R., Gawlik, A., Glodariu, T., Goncalves, I. F., González-Romero, E., Goverdovski, A., Griesmayer, E., Gunsing, F., Harada, H., Heftrich, T., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Kokkoris, M., Krticka, M., Leal-Cidoncha, E., Lederer-Woods, C., Leeb, H., Meo, S. Lo, Lonsdale, S. J., Losito, R., Macina, D., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Montesano, S., Musumarra, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, J. I., Praena, J., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Rout, P. C., Rubbia, C., Ryan, J. A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A. G., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Weiss, C., Wolf, C., Woods, P. J., Wright, T., Zugec, P., and Collaboration, the n_TOF
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Nuclear Experiment - Abstract
The design of fast reactors burning MOX fuels requires accurate capture and fission cross sections. For the particular case of neutron capture on 242Pu, the NEA recommends that an accuracy of 8-12% should be achieved in the fast energy region (2 keV-500 keV) compared to their estimation of 35% for the current uncertainty. Integral irradiation experiments suggest that the evaluated cross section of the JEFF-3.1 library overestimates the 242Pu(n,{\gamma}) cross section by 14% in the range between 1 keV and 1 MeV. In addition, the last measurement at LANSCE reported a systematic reduction of 20-30% in the 1-40 keV range relative to the evaluated libraries and previous data sets. In the present work this cross section has been determined up to 600 keV in order to solve the mentioned discrepancies. A 242Pu target of 95(4) mg enriched to 99.959% was irradiated at the n TOF-EAR1 facility at CERN. The capture cross section of 242Pu has been obtained between 1 and 600 keV with a systematic uncertainty (dominated by background subtraction) between 8 and 12%, reducing the current uncertainties of 35% and achieving the accuracy requested by the NEA in a large energy range. The shape of the cross section has been analyzed in terms of average resonance parameters using the FITACS code as implemented in SAMMY, yielding results compatible with our recent analysis of the resolved resonance region.The results are in good agreement with the data of Wisshak and K\"appeler and on average 10-14% below JEFF-3.2 from 1 to 250 keV, which helps to achieve consistency between integral experiments and cross section data. At higher energies our results show a reasonable agreement within uncertainties with both ENDF/B-VII.1 and JEFF-3.2. Our results indicate that the last experiment from DANCE underestimates the capture cross section of 242Pu by as much as 40% above a few keV., Comment: 20 pages, 19 figures, submitted to Phys. Rev. C
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- 2024
9. Definition of a European pre-vasectomy scoring system to identify patients at risk of vasectomy regret.
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Degraeve, Amandine, Tosco, Lorenzo, Tombal, Bertrand, Roumeguere, Thierry, Beirnaert, Jeanne, Hamal, Robin, Bugli, Céline, Cosentino, Marco, Gin Don, Lee, Skrodzka, Marta, Albersen, Maarten, van Renterghem, Koenraad, Sempels, Maxime, Penning, David, Fode, Mikkel, Faix, Antoine, Waterloos, Marjan, Gomez, Borja, Carnicelli, Damien, Graziana, Jean-Pierre, Morgado, Afonso, DHauwers, Kathleen, Serefoglu, Ege, Manfredi, Celeste, Weyne, Emmanuel, Beck, Jack, Osmonov, Daniar, Roller, Chris, Ferreti, Ludovic, Russo, Giogio, Yafi, Faysal, Cuzin, Beatrice, Madec, François-Xavier, Vanoverschelde, Geoffroy, Hervé, François, Chung, Eric, Nordström, Ulla, Cocci, Andrea, Zahr, Rawad, Triffaux, François, Suks, Minhas, Alnajjar, Hussain, Van Damme, Julien, and Ward, Sam
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male contraception ,male fertility ,reflection time ,regret risk factors ,scoring system ,semen cryopreservation ,vasectomy - Abstract
INTRODUCTION: Vasectomy is a widely used, safe, effective method of permanent contraception and contributes to healthy sexuality. AIMS: We have conducted a 3-step observational clinical study to develop a vasectomy regret risk score and guide patients and clinicians when discussing a vasectomy. METHODS: A 3-step approach has been followed. First, experts involved in male health have proposed risk factors for regret (remorse) after vasectomy, defined by a vasectomy reversal surgery or medically assisted reproduction. The selected factors were evaluated in 1200 patients vasectomized in the last 15 years. Finally, the expert panel has constructed a score for predicting regret after vasectomy. RESULTS: Fifty-two international experts identified 17 risk factors for vasectomy regret. Five of the risk factors were significant: an age
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- 2024
10. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei.
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Beaver, Alexander, Keneskhanova, Zhibek, Cosentino, Raúl, Weiss, Brian, Awuoche, Erick, Smallenberger, Gretchen, Buenconsejo, Gracyn, Crilly, Nathan, Smith, Jaclyn, Hakim, Jill, Zhang, Bailin, Bobb, Bryce, Rijo Ferreira, Filipa, Figueiredo, Luisa, Aksoy, Serap, Siegel, T, and Mugnier, Monica
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Antigenic Variation ,Animals ,Trypanosoma brucei brucei ,Variant Surface Glycoproteins ,Trypanosoma ,Trypanosomiasis ,African ,Mice ,Female ,Tsetse Flies ,Male ,High-Throughput Nucleotide Sequencing ,Antigens ,Protozoan - Abstract
The protozoan parasite Trypanosoma brucei evades clearance by the host immune system through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically switching expression of the VSG using a large genomic repertoire of VSG-encoding genes1-6. Recent studies of antigenic variation in vivo have focused near exclusively on parasites in the bloodstream6-8, but research has shown that many, if not most, parasites reside in the interstitial spaces of tissues9-13. We sought to explore the dynamics of antigenic variation in extravascular parasite populations using VSG-seq7, a high-throughput sequencing approach for profiling VSGs expressed in populations of T. brucei. Here we show that tissues, not the blood, are the primary reservoir of antigenic diversity during both needle- and tsetse bite-initiated T. brucei infections, with more than 75% of VSGs found exclusively within extravascular spaces. We found that this increased diversity is correlated with slower parasite clearance in tissue spaces. Together, these data support a model in which the slower immune response in extravascular spaces provides more time to generate the antigenic diversity needed to maintain a chronic infection. Our findings reveal the important role that extravascular spaces can have in pathogen diversification.
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- 2024
11. Towards a new generation of solid total-energy detectors for neutron-capture time-of-flight experiments with intense neutron beams
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Balibrea-Correa, J., Babiano-Suarez, V., Lerendegui-Marco, J., Domingo-Pardo, C., Ladarescu, I., Tarifeño-Saldivia, A., de la Fuente-Rosales, G., Gameiro, B., Zaitseva, N., Alcayne, V., Cano-Ott, D., González-Romero, E., Martínez, T., Mendoza, E., de Rada, A. Pérez, del Olmo, J. Plaza, Sánchez-Caballero, A., Casanovas, A., Calviño, F., Valenta, S., Aberle, O., Altieri, S., Amaducci, S., Andrzejewski, J., Bacak, M., Beltrami, C., Bennett, S., Bernardes, A. P., Berthoumieux, E., Beyer, R., Boromiza, M., Bosnar, D., Caamaño, M., Calviani, M., Castelluccio, D. M., Cerutti, F., Cescutti, G., Chasapoglou, S., Chiaveri, E., Colombetti, P., Colonna, N., Camprini, P. Console, Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Dellmann, S., Di Castro, M., Di Maria, S., Diakaki, M., Dietz, M., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fargier, S., Fernández, B., Fernández-Domínguez, B., Finocchiaro, P., Fiore, S., Furman, V., García-Infantes, F., Gawlik-Ramikega, A., Gervino, G., Gilardoni, S., Guerrero, C., Gunsing, F., Gustavino, C., Heyse, J., Hillman, W., Jenkins, D. G., Jericha, E., Junghans, A., Kadi, Y., Kaperoni, K., Kaur, G., Kimura, A., Knapová, I., Kokkoris, M., Kopatch, Y., Krtìvcka, M., Kyritsis, N., Lederer-Woods, C., Lerner, G., Manna, A., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mucciola, R., Murtas, F., Musacchio-Gonzalez, E., Musumarra, A., Negret, A., Pérez-Maroto, P., Patronis, N., Pavón-Rodríguez, J. A., Pellegriti, M. G., Perkowski, J., Petrone, C., Pirovano, E., Pomp, S., Porras, I., Praena, J., Quesada, J. M., Reifarth, R., Rochman, D., Romanets, Y., Rubbia, C., Sabaté-Gilarte, M., Schillebeeckx, P., Schumann, D., Sekhar, A., Smith, A. G., Sosnin, N. V., Stamati, M. E., Sturniolo, A., Tagliente, G., Tarrío, D., Torres-Sánchez, P., Vagena, E., Variale, V., Vaz, P., Vecchio, G., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., Zarrella, R., and Zugec, P.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
Challenging neutron-capture cross-section measurements of small cross sections and samples with a very limited number of atoms require high-flux time-of-flight facilities. In turn, such facilities need innovative detection setups that are fast, have low sensitivity to neutrons, can quickly recover from the so-called $\gamma$-flash, and offer the highest possible detection sensitivity. In this paper, we present several steps toward such advanced systems. Specifically, we describe the performance of a high-sensitivity experimental setup at CERN n\_TOF EAR2. It consists of nine sTED detector modules in a compact cylindrical configuration, two conventional used large-volume C$_{6}$D$_{6}$ detectors, and one LaCl$_{3}$(Ce) detector. The performance of these detection systems is compared using $^{93}$Nb($n$,$\gamma$) data. We also developed a detailed \textsc{Geant4} Monte Carlo model of the experimental EAR2 setup, which allows for a better understanding of the detector features, including their efficiency determination. This Monte Carlo model has been used for further optimization, thus leading to a new conceptual design of a $\gamma$ detector array, STAR, based on a deuterated-stilbene crystal array. Finally, the suitability of deuterated-stilbene crystals for the future STAR array is investigaged experimentally utilizing a small stilbene-d12 prototype. The results suggest a similar or superior performance of STAR with respect to other setups based on liquid-scintillators, and allow for additional features such as neutron-gamma discrimination and a higher level of customization capability.
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- 2024
12. Interaction between the Supernova Remnant W44 and the Infrared Dark Cloud G034.77-00.55: shock induced star formation?
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Cosentino, G., Jiménez-Serra, I., Barnes, A. T., Tan, J. C., Fontani, F., Caselli, P., Henshaw, J. D., Law, C. Y., Viti, S., Fedriani, R., Hsu, C. -J., Gorai, P., Zeng, S., and De Simone, M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
How Supernova Remnant (SNR) shocks impact nearby molecular clouds is still poorly observationally constrained. It is unclear if SNRs can positively or negatively affect clouds star formation potential. We have studied the dense gas morphology and kinematics toward the Infrared Dark Cloud (IRDC) G034.77-00.55, shock-interacting with the SNR W44, to identify evidence of early stage star formation induced by the shock. We have used high-angular resolution N2H+(1-0) images across G034.77-00.55, obtained with ALMA. N2H+ is a well known tracer of dense and cold material, optimal to identify gas with the highest potential to harbour star formation. The N2H+ emission is distributed into two elongated structures, one toward the dense ridge at the edge of the source and one toward the inner cloud. Both elongations are spatially associated with well-defined mass-surface density features. The velocities of the gas in the two structures i.e., 38-41 km s-1 and 41-43 km s-1 are consistent with the lowest velocities of the J- and C-type parts of the SNR-driven shock, respectively. A third velocity component is present at 43-45.5 km s-1. The dense gas shows a fragmented morphology with core-like fragments of scales consistent with the Jeans lengths, masses $\sim$1-20 M$_{\odot}$, densities (n(H$_2$)$\geq$10$^5$ cm$^{-3}$) sufficient to host star formation in free-fall time scales (few 10$^4$ yr) and with virial parameters that hint toward possible collapse. The W44 driven shock may have swept up the encountered material which is now seen as a dense ridge, almost detached from the main cloud, and an elongation within the inner cloud, well constrained in both N2H+ emission and mass surface density. This shock compressed material may have then fragmented into cores that are either in a starless or pre-stellar stage. Additional observations are needed to confirm this scenario and the nature of the cores., Comment: 12 pages, 8 figures, accepted for publication in A&A
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- 2024
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13. The SOFIA Massive (SOMA) Star Formation Q-band follow-up I. Carbon-chain chemistry of intermediate-mass protostars
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Taniguchi, Kotomi, Gorai, Prasanta, Tan, Jonathan C., Gomez-Garrido, Miguel, Fedriani, Ruben, Yang, Yao-Lun, Sridharan, T. K., Tanaka, Kei, Saito, Masao, Zhang, Yichen, Morgan, Lawrence, Cosentino, Giuliana, and Law, Chi-Yan
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Evidence for similar chemical characteristics around low- and high-mass protostars has been found: in particular, a variety of carbon-chain species and complex organic molecules (COMs) are formed around them. On the other hand, the chemical compositions around intermediate-mass (IM; $2 M_{\odot} < m_* <8 M_{\odot}$) protostars have not been studied with large samples. In particular, it is unclear the extent to which carbon-chain species are formed around them. We aim to obtain the chemical compositions, particularly focusing on carbon-chain species, towards a sample of IM protostars. We have conducted Q-band (31.5-50 GHz) line survey observations towards eleven mainly intermediate-mass protostars with the Yebes 40 m radio telescope. The target protostars were selected from a sub-sample of the source list of the SOFIA Massive (SOMA) Star Formation project. Nine carbon-chain species (HC$_3$N, HC$_5$N, C$_3$H, C$_4$H, $linear-$H$_2$CCC, $cyclic-$C$_3$H$_2$, CCS, C$_3$S, and CH$_3$CCH), three COMs (CH$_3$OH, CH$_3$CHO, and CH$_3$CN), H$_2$CCO, HNCO, and four simple sulfur (S)-bearing species ($^{13}$CS, C$^{34}$S, HCS$^+$, H$_2$CS) have been detected. The rotational temperatures of HC$_5$N are derived to be $\sim20-30$ K in three IM protostars and they are very similar compared to those around low- and high-mass protostars. These results indicate that carbon-chain molecules are formed in lukewarm ($\sim20-30$ K) gas around the IM protostars by the Warm Carbon-Chain Chemistry (WCCC) process. Carbon-chain formation occurs ubiquitously in the warm gas around protostars across a wide range of stellar masses. Carbon-chain molecules and COMs coexist around most of the target IM protostars, which is similar to the situation in low- and high-mass protostars. The chemical characteristics around protostars are common in the low-, intermediate- and high-mass regimes., Comment: Accepted for publication in the Astronomy and Astrophysics (A&A)
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- 2024
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14. The fast rise of the unusual Type IIL/IIb SN 2018ivc
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Reguitti, A., Dastidar, R., Pignata, G., Maeda, K., Moriya, T. J., Kuncarayakti, H., Rodríguez, Ó., Bersten, M., Anderson, J. P., Charalampopoulos, P., Fraser, M., Gromadzki, M., Young, D. R., Benetti, S., Cai, Y. -Z., Elias-Rosa, N., Lundqvist, P., Carini, R., Cosentino, S. P., Galbany, L., Gonzalez-Bañuelos, M., Gutiérrez, C. P., Kopsacheili, M., G., J. A. Pineda, and Ramirez, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present an analysis of the photometric and spectroscopic dataset of the Type II supernova (SN) 2018ivc in the nearby (10 Mpc) galaxy Messier 77. Thanks to the high cadence of the CHASE survey, we observed the SN rising very rapidly by nearly three magnitudes in five hours (or 18 mag d$^{-1}$). The $r$-band light curve presents four distinct phases: the maximum light is reached in just one day, then a first, rapid linear decline precedes a short-duration plateau. Finally, a long, slower linear decline lasted for one year. Following a radio rebrightening, we detected SN 2018ivc four years after the explosion. The early spectra show a blue, nearly featureless continuum, but the spectra evolve rapidly: after about 10 days a prominent H$\alpha$ line starts to emerge, with a peculiar profile, but the spectra are heavily contaminated by emission lines from the host galaxy. He I lines, namely $\lambda\lambda$5876,7065, are also strong. On top of the former, a strong absorption from the Na I doublet is visible, indicative of a non-negligible internal reddening. From its equivalent width, we derive a lower limit on the host reddening of $A_V\simeq1.5$ mag, while from the Balmer decrement and a match of the $B-V$ colour curve of SN 2018ivc to that of the comparison objects, a host reddening of $A_V\simeq3.0$ mag is obtained. The spectra are similar to those of SNe II, but with strong He lines. Given the peculiar light curve and spectral features, we suggest SN 2018ivc could be a transitional object between the Type IIL and Type IIb SNe classes. In addition, we found signs of interaction with circumstellar medium in the light curve, making SN 2018ivc also an interacting event. Finally, we modelled the early multi-band light curves and photospheric velocity of SN 2018ivc to estimate the explosion and CSM physical parameters., Comment: 19 pages, 22 figures, 3 tables, 3 appendices, accepted for publication on A&A
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- 2024
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15. The GAPS Programme at TNG. LXI. Atmospheric parameters and elemental abundances of TESS young exoplanet host stars
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Filomeno, S., Biazzo, K., Baratella, M., Benatti, S., D'Orazi, V., Desidera, S., Mancini, L., Messina, S., Polychroni, D., Turrini, D., Cabona, L., Carleo, I., Damasso, M., Malavolta, L., Mantovan, G., Nardiello, D., Scandariato, G., Sozzetti, A., Zingales, T., Andreuzzi, G., Antoniucci, S., Bignamini, A., Bonomo, A. S., Claudi, R., Cosentino, R., Fiorenzano, A. F. M., Fonte, S., Harutyunyan, A., and Knapic, C.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The study of exoplanets at different evolutionary stages can shed light on their formation, migration, and evolution. The determination of exoplanet properties depends on the properties of their host stars. It is therefore important to characterise the host stars for accurate knowledge on their planets. Our final goal is to derive, in a homogeneous and accurate way, the stellar atmospheric parameters and elemental abundances of ten young TESS transiting planet-hosting GK stars followed up with the HARPS-N at TNG spectrograph within the GAPS programme. We derived stellar kinematic properties, atmospheric parameters, and abundances of 18 elements. Lithium line measurements were used as approximate age estimations. We exploited chemical abundances and their ratios to derive information on planetary composition. Elemental abundances and kinematic properties are consistent with the nearby Galactic thin disk. All targets show C/O<0.8 and 1.0
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- 2024
16. Educating and Training in Research Integrity (RI): A Study on the Perceptions and Experiences of Early Career Researchers Attending an Institutional RI Course
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Greco Francesca, Silvia Ceruti, Stefano Martini, Mario Picozzi, Marco Cosentino, and Franca Marino
- Abstract
Research integrity (RI) is defined as adherence to ethical principles, deontological duties, and professional standards necessary for responsible conduct of scientific research. Early training on RI, especially for early-career researchers, could be useful to help develop good standards of conduct and prevent research misconduct (RM).The aim of this study is to assess the effectiveness of a training course on RI, by mapping the attitudes of early-career researchers on this topic through a questionnaire built upon the revised version of the Scientific Misconduct Questionnaire and administered to all participants at the beginning and at the end of the course. Results show that after the course, participants reporting a high understanding of the rules and procedures related to RM significantly increased (pre-course: 38.5%, post-course: 61.5%), together with the percentage of those reporting a lack of awareness on the extent of misconduct (pre-course: 46.2%, post-course: 69.2%), and of those who believe that the lack of research ethics consultation services strongly affects RM (pre-course: 15.4%, post-course: 61.5%). Early-career researchers agree on the importance to share with peers and superiors any ethical concern that may arise in research, and to create a work environment that fosters RI awareness. As a whole, results suggest the effectiveness of the course. Institutions should introduce RI training for early-career researchers, together with research methodology, integrity and ethics consultation services to support them. Senior scientists should promote RI into their research practices, and should stimulate engagement in peer-to-peer dialogue to develop good practices based on RI principles.
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- 2024
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17. Mathematics MOVES Me—Digital Solutions for Co-ordinating Enactive and Symbolic Resources: The Case of Positive and Negative Integer Arithmetic
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Anton, Jacqueline, Cosentino, Giulia, Gelsomini, Mirko, Sharma, Kshitij, Giannakos, Michail N, and Abrahamson, Dor
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Psychology ,Education ,Applied and Developmental Psychology - Published
- 2024
18. The GAPS Programme at TNG. LIX. A characterisation study of the $\sim$300 Myr old multi-planetary system orbiting the star BD+40 2790 (TOI-2076)
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Damasso, M., Locci, D., Benatti, S., Maggio, A., Baratella, M., Desidera, S., Biazzo, K., Palle, E., Wang, S., Nardiello, D., Borsato, L., Bonomo, A. S., Messina, S., Nowak, G., Goyal, A., Bejar, V. J. S., Bignamini, A., Cabona, L., Carleo, I., Claudi, R., Cosentino, R., Filomeno, S., Knapic, C., Lodieu, N., Lorenzi, V., Malavolta, L., Mallorquin, M., Mancini, L., Mantovan, G., Micela, G., Murgas, F., Orell-Miquel, J., Pedani, M., Pinamonti, M., Sozzetti, A., Spinelli, R., Osorio, M. R. Zapatero, and Zingales, T.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We collected more than 300 high-resolution spectra of the 300 Myr old star BD+40 2790 (TOI-2076) over ~3 years. This star hosts three transiting planets discovered by TESS, with orbital periods ~10, 21, and 35 days. BD+40 2790 shows an activity-induced scatter larger than 30 m/s in the radial velocities. We employed different methods to measure the stellar radial velocities and several models to filter out the dominant stellar activity signal, in order to bring to light the planet-induced signals which are expected to have semi-amplitudes one order of magnitude lower. We evaluated the mass loss rate of the planetary atmospheres using photoionization hydrodynamic modeling. The dynamical analysis confirms that the three sub-Neptune-sized companions (our radius measurements are $R_b$=2.54$\pm$0.04, $R_c$=3.35$\pm$0.05, and $R_d$=3.29$\pm$0.06 $R_{\rm Earth}$) have masses in the planetary regime. We derive 3$\sigma$ upper limits below or close to the mass of Neptune for all the planets: 11--12, 12--13.5, and 14--19 $M_{\rm Earth}$ for planet $b$, $c$, and $d$ respectively. In the case of planet $d$, we found promising clues that the mass could be between ~7 and 8 $M_{\rm Earth}$, with a significance level between 2.3--2.5$\sigma$ (at best). This result must be further investigated using other analysis methods or using high-precision near-IR spectrographs to collect new radial velocities, which could be less affected by stellar activity. Atmospheric photo-evaporation simulations predict that BD+40~2790 b is currently losing its H-He gaseous envelope, which will be completely lost at an age within 0.5--3 Gyr if its current mass is lower than 12 $M_{\rm Earth}$. BD+40 2790 c could have a lower bulk density than $b$, and it could retain its atmosphere up to an age of 5 Gyr. For the outermost planet $d$, we predict almost negligible evolution of its mass and radius induced by photo-evaporation., Comment: Accepted for publication on A&A. Abstract abridged
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- 2024
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19. A Harnack type inequality for singular Liouville type equations
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Cosentino, Paolo
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Mathematics - Analysis of PDEs - Abstract
We obtain a Harnack type inequality for solutions of the Liouville type equation, \begin{equation}\nonumber -\Delta u=|x|^{2\alpha}K(x)e^{\displaystyle u} \qquad\text{in} \,\,\, \Omega, \end{equation} where $\alpha\in(-1,0)$, $\Omega$ is a bounded domain in $\mathbb{R}^2$ and $K$ satisfies, \begin{equation}\nonumber 0
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- 2024
20. End-to-End simulation framework for astronomical spectrographs: SOXS, CUBES and ANDES
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Scaudo, A., Genoni, M., Causi, G. Li, Cabona, L., Landoni, M., Campana, S., Schipani, P., Claudi, R., Aliverti, M., Baruffolo, A., Ben-Ami, S., Biondi, F., Capasso, G., Cosentino, R., D'Alessio, F., D'Avanzo, P., Hershko, O., Kuncarayakti, H., Munari, M., Santhakumari, K. Radhakrishnan, Pignata, G., Rubin, A., Scuderi, S., Vitali, F., Young, D., Achrén, J., Araiza-Duran, J. A., Arcavi, I., Battaini, F., Brucalassi, A., Bruch, R., Cappellaro, E., Colapietro, M., Della Valle, M., De Pascale, M., Di Benedetto, R., D'Orsi, S., Gal-Yam, A., Hernandez, M., Kotilainen, J., Marty, L., Mattila, S., Rappaport, M., Ricci, D., Riva, M., Salasnich, B., Smartt, S., Sanchez, R. Zanmar, Stritzinger, M., Ventura, H., Cupani, G., Porru, M., Franchini, M., Cirami, R., Calderone, G., Covino, S., Smiljanic, R., Monteiro, M., Balestra, A., Sordo, R., Mason, E., Rousseu, S., Leão, I. de Castro, Zanutta, A., Martins, A. de Meideros, Sosnowska, D., Marquart, T., Boisse, I., Sousa, S., Hernandez, J., Piskunov, N., Puschnig, J., Senna, N., Martins, B., Di Marcantonio, P., and Marconi, A.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present our numerical simulation approach for the End-to-End (E2E) model applied to various astronomical spectrographs, such as SOXS (ESO-NTT), CUBES (ESO-VLT), and ANDES (ESO-ELT), covering multiple wavelength regions. The E2E model aim at simulating the expected astronomical observations starting from the radiation of the scientific sources (or calibration sources) up to the raw-frame data produced by the detectors. The comprehensive description includes E2E architecture, computational models, and tools for rendering the simulated frames. Collaboration with Data Reduction Software (DRS) teams is discussed, along with efforts to meet instrument requirements. The contribution to the cross-correlation algorithm for the Active Flexure Compensation (AFC) system of CUBES is detailed., Comment: 19 pages, 17 figures, SPIE Astronomical Telescopes + Instrumentation, Yokohama 2024. arXiv admin note: text overlap with arXiv:2209.07185, arXiv:2012.12684
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- 2024
21. Final Alignment and Image Quality Test for the Acquisition and Guiding System of SOXS
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Araiza-Duran, J. A., Pignata, G., Brucalassi, A., Aliverti, M., Battaini, F., Radhakrishnan, K., Di Filippo, S., Lessio, L., Claudi, R., Ricci, D., Colapietro, M., Cosentino, R., D'Orsi, S., Munari, M., Dima, M., Schipani, P., Campana, S., Baruffolo, A., Sanchez, R. Zanmar, Riva, M., Genoni, M., Ben-Ami, S., Rubin, A., Bruch, R., Capasso, G., D'Alessio, F., D'Avanzo, P., Hershko, O., Kuncarayakti, H., Landoni, M., Scuderi, S., Vitali, F., Young, D., Achren, J., Arcavi, I., Cappellaro, E., Della Valle, M., Di Benedetto, R., Gal-Yam, A., Diaz, M. Hernandez, Kotilainen, J., Causi, G. Li, Marty, L., Mattila, S., Rappaport, M., Salasnich, B., Smartt, S., Stritzinger, M., Ventura, H. Perez, Asquini, L., Bichkovsky, A., Savarese, S., and Cabona, L.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
SOXS (Son Of X-Shooter) will be the new medium-resolution (R 4500 for 1 slit), high-efficiency, wide-band spectrograph for the ESO NTT at La Silla Observatory, Chile. It will be dedicated to the follow-up of any kind of transient events, ensuring fast time, high efficiency, and availability. It consists of a central structure (common path) that supports two spectrographs optimized for the UV-Visible and a Near-Infrared range. Attached to the common path is the Acquisition and Guiding Camera system (AC), equipped with a filter wheel that can provide science-grade imaging and moderate high-speed photometry. The AC Unit was integrated and aligned during the summer months of 2022 and has since been mounted in the NTTs telescope simulator. This work gives an update on the Acquisition Camera Unit status, describes the Image Quality Tests that were performed, and discusses the AC Optical Performance., Comment: SPIE Proceedings Volume 13096, Ground-based and Airborne Instrumentation for Astronomy X; 1309672 (2024)
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- 2024
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22. The integration of the SOXS control electronics towards the PAE
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Colapietro, Mirko, D'Orsi, Sergio, Capasso, Giulio, Savarese, Salvatore, Schipani, Pietro, Marty, Laurent, Sanchez, Ricardo Zanmar, Aliverti, Matteo, Battaini, Federico, Di Filippo, Simone, Santhakumari, Kalyan Kumar Radhakrishnan, Ricci, Davide, Salasnich, Bernardo, Campana, Sergio, Claudi, Riccardo, Araiza-Duran, Jose, Baruffolo, Andrea, Ami, Sagi Ben, Bichkovsky, Alex, Brucalassi, Anna, Cosentino, Rosario, D'Alessio, Francesco, D'Avanzo, Paolo, Di Benedetto, Rosario, Genoni, Matteo, Hershko, Ofir, Kuncarayakti, Hanindyo, Lessio, Luigi, Martinetti, Eugenio, Micciche, Antonio, Nicotra, Gaetano, Pignata, Giuliano, Rubin, Adam, Scuderi, Salvatore, Vitali, Fabrizio, Achren, Jani, Arcavi, Iair, Asquini, Laura, Bruch, Rachel, Cappellaro, Enrico, Della Valle, Massimo, Gal-Yam, Avishay, Diaz, Marcos Hernandez, Kotilainen, Jari, Landoni, Marco, Causi, Gianluca Li, Mattila, Seppo, Munari, Matteo, Ventura, Hector Perez, Rappaport, Michael, Riva, Marco, Smartt, Steven, Stritzinger, Maximilian, and Young, David
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
SOXS (Son Of X-Shooter) is the new single object spectrograph for the ESO New Technology Telescope (NTT) at the La Silla Observatory, able to cover simultaneously both the UV-VIS and NIR bands (350-2000 nm). The instrument is currently in the integration and test phase, approaching the Preliminary Acceptance in Europe (PAE) before shipment to Chile for commissioning. After the assembly and preliminary test of the control electronics at INAF - Astronomical Observatory of Capodimonte (Napoli), the two main control cabinets of SOXS are now hosted in Padova, connected to the real hardware. This contribution describes the final electronic cabinets layout, the control strategy and the different integration phases, waiting for the Preliminary Acceptance in Europe and the installation of the instrument in Chile.
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- 2024
23. What is your favorite transient event? SOXS is almost ready to observe!
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Santhakumari, Kalyan Kumar Radhakrishnan, Battaini, Federico, Di Filippo, Simone, Di Rosa, Silvio, Cabona, Lorenzo, Claudi, Riccardo, Lessio, Luigi, Dima, Marco, Young, David, Landoni, Marco, Colapietro, Mirko, D'Orsi, Sergio, Aliverti, Matteo, Genoni, Matteo, Munari, Matteo, Sanchez, Ricardo Zanmar, Vitali, Fabrizio, Ricci, Davide, Schipani, Pietro, Campana, Sergio, Achren, Jani, Araiza-Duran, Jose, Arcavi, Iair, Baruffolo, Andrea, Ben-Ami, Sagi, Bitchkovsky, Alex, Brucalassi, Anna, Bruch, Rachel, Capasso, Giulio, Cappellaro, Enrico, Cosentino, Rosario, D'Alessio, Francesco, D'Avanzo, Paolo, Della Valle, Massimo, Di Benedetto, Rosario, Gal-Yam, Avishay, Diaz, Marcos Hernandez, Hershko, Ofir, Kotilainen, Jari, Kuncarayakti, Hanindyo, Causi, Gianluca Li, Marafatto, Luca, Martinetti, Eugenio, Marty, Laurent, Mattila, Seppo, Micciche, Antonio, Nicotra, Gaetano, Oggioni, Luca, Ventura, Hector Perez, Pariani, Giorgio, Pignata, Giuliano, Rappaport, Michael, Riva, Marco, Rubin, Adam, Salasnich, Bernardo, Savarese, Salvatore, Scuderi, Salvatore, Smartt, Steven, and Stritzinger, Maximilian
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The Son Of X-Shooter (SOXS) will be the specialized facility to observe any transient event with a flexible scheduler at the ESO New Technology Telescope (NTT) at La Silla, Chile. SOXS is a single object spectrograph offering simultaneous spectral coverage in UV-VIS (350-850 nm) and NIR (800-2000 nm) wavelength regimes with an average of R~4500 for a 1arcsec slit. SOXS also has imaging capabilities in the visible wavelength regime. Currently, SOXS is being integrated at the INAF-Astronomical Observatory of Padova. Subsystem- and system-level tests and verification are ongoing to ensure and confirm that every requirement and performance are met. In this paper, we report on the integration and verification of SOXS as the team and the instrument prepare for the Preliminary Acceptance Europe (PAE).
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- 2024
24. The status of the NIR arm of the SOXS Instrument toward the PAE
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Vitali, Fabrizio, Genoni, Matteo, Aliverti, Matteo, Radhakrishnan, Kalyan, Battaini, Federico, D'Avanzo, Paolo, D'Alessio, Francesco, Pariani, Giorgio, Oggioni, Luca, Scuderi, Salvatore, Ricci, Davide, Martinetti, Eugenio, Miccichè, Antonio, Nicotra, Gaetano, Colapietro, Mirko, D'Orsi, Sergio, Munari, Matteo, Lessio, Luigi, Di Filippo, Simone, Scaudo, Andrea, Bellassai, Giancarlo, Di Benedetto, Rosario, Occhipinti, Giovanni, Landoni, Marco, Accardo, Matteo, Mehrgan, Leander, Ives, Derek, Scirè, Carlotta, Campana, Sergio, Schipani, Pietro, Claudi, Riccardo, Capasso, Giulio, Riva, Marco, Sanchez, Ricardo Zanmar, Araiza-Durán, José Antonio, Arcavi, Iair, Baruffolo, Andrea, Ben-Ami, Sagi, Brucalassi, Anna, Bruch, Rachel, Cappellaro, Enrico, Cosentino, Rosario, De Pascale, Marco, Della Valle, Massimo, Gal-Yam, Avishay, Díaz, Marcos Hernandez, Hershko, Ofir, Kotilainen, Jari, Kuncarayakti, Hanindyo, Causi, Gianluca Li, Marty, Laurent, Mattila, Seppo, Ventura, Hector Pérez, Pignata, Giuliano, Rappaport, Michael, Rubin, Adam, Salasnich, Bernardo, Smartt, Stephen, Stritzinger, Maximilian, and Young, David
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Son Of X-Shooter (SOXS) is a single object spectrograph, built by an international consortium for the 3.58-m ESO New Technology Telescope at the La Silla Observatory [1]. It offers a simultaneous spectral coverage over 350-2000 nm, with two separate spectrographs. In this paper we present the status of the Near InfraRed (NIR) cryogenic echelle cross-dispersed spectrograph [1], in the range 0.80-2.00 {\mu}m with 15 orders, equipped with an 2k x 2k Hawaii H2RG IR array from Teledyne, working at 40K, that is currently assembled and tested on the SOXS instrument, in the premises of INAF in Padova. We describe the different tests and results of the cryo, vacuum, opto-mechanics and detector subsystems that finally will be part of the PAE by ESO., Comment: 8 Pages, 7 Figures, Astronomical Telescopes and Instrumentation, SPIE Proceedings 2024
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- 2024
25. Automated scheduler for the SOXS instrument: design and performance
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Asquini, Laura, Landoni, Marco, Young, Dave, Marty, Laurent, Smartt, Stephen J., Campana, Sergio, Claudi, Riccardo, Schipani, Pietro, Achren, Jani, Aliverti, Matteo, Duran, Jose A. Araiza, Arcavi, Iair, Battaini, Federico, Baruffolo, Andrea, Ami, Sagi Ben, Bianco, Andrea, Bichkovsky, Alex, Brucalassi, Anna, Bruch, Rachel, Capasso, Giulio, Cappellaro, Enrico, Colapietro, Mirko, Cosentino, Rosario, DÁlessio, Francesco, D'Avanzo, Paolo, Della Valle, Massimo, D'Orsi, Sergio, Di Benedetto, Rosario, Di Filippo, Simone, Yam, Avishay Gal, Genoni, Matteo, Hernandez, Marcos, Hershko, Ofir, Kotilainen, Jari, Kuncarayakti, Hanindyo, Causi, Gianluca Li, Mattila, Seppo, Munari, Matteo, Pariani, Giorgio, Ventura, Hector Perez, Pignata, Giuliano, Radhakrishnan, Kalyan, Rappaport, Michael, Ricci, Davide, Riva, Marco, Rubin, Adam, Salasnich, Bernardo, Savarese, Salvatore, Stritzinger, Maximilian, Scuderi, Salvatore, Vitali, Fabrizio, and Sanchez, Ricardo Zanmar
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the advancements in the development of the scheduler for the Son Of X-shooter instrument at the ESO-NTT 3.58-m telescope in La Silla, Chile. SOXS is designed as a single-object spectroscopic facility and features a high-efficiency spectrograph with two arms covering the spectral range of 350-2000 nm and a mean resolving power of approximately R=4500. It will conduct UV-visible and near-infrared follow-up observations of astrophysical transients, drawing from a broad pool of targets accessible through the streaming services of wide-field telescopes, both current and future, as well as high-energy satellites. The instrument will cater to various scientific objectives within the astrophysical community, each entailing specific requirements for observation planning. SOXS will operate at the European Southern Observatory (ESO) in La Silla, without the presence of astronomers on the mountain. This poses a unique challenge for the scheduling process, demanding a fully automated algorithm that is autonomously interacting with the appropriate databases and the La Silla Weather API, and is capable of presenting the operator not only with an ordered list of optimal targets (in terms of observing constraints) but also with optimal backups in the event of changing weather conditions. This imposes the necessity for a scheduler with rapid-response capabilities without compromising the optimization process, ensuring the high quality of observations and best use of the time at the telescope. We thus developed a new highly available and scalable architecture, implementing API Restful applications like Docker Containers, API Gateway, and Python-based Flask frameworks. We provide an overview of the current state of the scheduler, which is now ready for the approaching on-site testing during Commissioning phase, along with insights into its web interface and preliminary performance tests.
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- 2024
26. Characterisation and assessment of the SOXS Spectrograph UV-VIS Detector System
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Cosentino, R., Hernandez, M., Ventura, H., Campana, S., Claudi, R., Schipani, P., Aliverti, M., Asquini, L., Baruffolo, A., Battaini, F., Ben-Ami, Sagi, Bichkovsky, A., Capasso, G., D'Alessio, F., D'Avanzo, P., Hershko, O., Kuncarayakti, H., Landoni, M., Munari, M., Pignata, G., Rubin, A., Scuderi, S., Vitali, F., Young, D., Achren, J., Araiza-Duran, J. A., Arcavi, I., Brucalassi, A., Bruch, R., Cappellaro, E., Colapietro, M., Della Valle, M., Di Benedetto, R., Di Filippo, S., D'Orsi, S., Gal-Yam, A., Genoni, M., Kotilainen, J., Causi, G. Li, Marty, L., Mattila, S., Rappaport, M., Radhakrishnan, K., Ricci, D., Riva, M., Salasnich, B., Savarese, S., Smartt, S., Sanchez, R. Zanmar, Stritzinger, M., Accardo, M., Mehrgan, L. H., and Ives, D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The SOXS spectrograph, designed for the ESO NTT telescope, operates in both the optical (UV-VIS: 350-850 nm) and NIR (800-2000 nm) bands. This article provides an overview of the final tests conducted on the UV-VIS camera system using a telescope simulator. It details the system's performance evaluation, including key metrics such as gain, readout noise, and linearity, and highlights the advancements made in the upgraded acquisition system. The testing process, conducted in the Padua laboratory, involved comprehensive simulations of the telescope environment to ensure the results closely resemble those expected at the ESO-NTT telescope. The successful completion of these tests confirms the system's readiness for deployment to Chile, where it will be installed on the NTT telescope, marking a significant milestone in the SOXS project., Comment: SPIE Proceedings Volume 13096, Ground-based and Airborne Instrumentation for Astronomy X; 130962U (2024)
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- 2024
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27. SOXS NIR: Optomechanical integration and alignment, optical performance verification before full instrument assembly
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Genoni, M., Aliverti, M., Pariani, G., Oggioni, L., Vitali, F., D'Alessio, F., D'Avanzo, P., Campana, S., Munari, M., Sanchez, R. Zanmar, Scaudo, A., Landoni, M., Young, D., Scuderi, S., Schipani, P., Riva, M., Claudi, R., Radhakrishnan, K., Battaini, F., Rubin, A., Baruffolo, A., Capasso, G., Cosentino, R., Hershko, O., Kuncarayakti, H., Pignata, G., Ben-Ami, S., Brucalassi, A., Achren, J., Araiza-Duran, J. A., Arcavi, I., Asquini, L., Bruch, R., Cappellaro, E., Colapietro, M., Della Valle, M., De Pascale, M., Di Benedetto, R., D'Orsi, S., Gal-Yam, A., Diaz, M. Hernandez, Kotilainen, J., Causi, G. Li, Marty, L., Mattila, S., Rappaport, M., Ricci, D., Salasnich, B., Smartt, S., Stritzinger, M., and Ventura, H.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
This paper presents the opto-mechanical integration and alignment, functional and optical performance verification of the NIR arm of Son Of X-Shooter (SOXS) instrument. SOXS will be a single object spectroscopic facility for the ESO-NTT 3.6-m telescope, made by two arms high efficiency spectrographs, able to cover the spectral range 350 2050 nm with a mean resolving power R~4500. In particular the NIR arm is a cryogenic echelle cross-dispersed spectrograph spanning the 780-2050 nm range. We describe the integration and alignment method performed to assemble the different opto-mechanical elements and their installation on the NIR vacuum vessel, which mostly relies on mechanical characterization. The tests done to assess the image quality, linear dispersion and orders trace in laboratory conditions are summarized. The full optical performance verification, namely echellogram format, image quality and resulting spectral resolving power in the whole NIR arm (optical path and science detector) is detailed. Such verification is one of the most relevant prerequisites for the subsequent full instrument assembly and provisional acceptance in Europe milestone, foreseen in 2024., Comment: SPIE Proceedings Volume 13096, Ground-based and Airborne Instrumentation for Astronomy X; 130962T (2024)
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- 2024
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28. Walking with SOXS towards the transient sky
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Schipani, P., Campana, S., Claudi, R., Aliverti, M., Baruffolo, A., Ben-Ami, S., Capasso, G., Colapietro, M., Cosentino, R., D'Alessio, F., D'Avanzo, P., Genoni, M., Hershko, O., Kuncarayakti, H., Landoni, M., Munari, M., Pignata, G., Radhakrishnan, K., Ricci, D., Rubin, A., Scuderi, S., Vitali, F., Young, D., Accardo, M., Achrén, J., Araiza-Durán, J. A., Arcavi, I., Asquini, L., Battaini, F., Bichkovsky, A., Brucalassi, A., Bruch, R., Cabona, L., Cappellaro, E., Della Valle, M., Di Filippo, S., Di Benedetto, R., D'Orsi, S., Gal-Yam, A., Hernandez, M., Ives, D., Kaeufl, H. -U., Kotilainen, J., Causi, G. Li, Lessio, L., Marty, L., Mattila, S., Mehrgan, L., Pasquini, L., Pompei, E., Rappaport, M., Riva, M., Salasnich, B., Savarese, S., Saviane, I., Schöller, M., Silber, A., Smartt, S., Sanchez, R. Zanmar, Stritzinger, M., Sulich, A., and Ventura, H.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
SOXS (Son Of X-Shooter) is the new ESO instrument that is going to be installed on the 3.58-m New Technology Telescope at the La Silla Observatory. SOXS is a single object spectrograph offering a wide simultaneous spectral coverage from U- to H-band. Although such an instrument may have potentially a large variety of applications, the consortium designed it with a clear science case: it is going to provide the spectroscopic counterparts to the ongoing and upcoming imaging surveys, becoming one of the main follow-up instruments in the Southern hemisphere for the classification and characterization of transients. The NTT+SOXS system is specialized to observe all transients and variable sources discovered by imaging surveys with a flexible schedule maintained by the consortium, based on a remote scheduler which will interface with the observatory software infrastructure. SOXS is realized timely to be highly synergic with transients discovery machines like the Vera C. Rubin Observatory. The instrument has been integrated and tested in Italy, collecting and assembling subsystems coming from all partners spread over six countries in three continents. The first preparatory activities in Chile have been completed at the telescope. This article gives an updated status of the project before the shipping of the instrument to Chile., Comment: SPIE Astronomical Telescopes + Instrumentation, 2024, Yokohama, Japan
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- 2024
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29. The SOXS Instrument Control Software approaching the PAE
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Ricci, Davide, Salasnich, Bernardo, Baruffolo, Andrea, Achrén, Jani, Aliverti, Matteo, Araiza-Durán, José A., Arcavi, Iair, Asquini, Laura, Battaini, Federico, Ben-Ami, Sagi, Bichkovsky, Alex, Brucalassi, Anna, Bruch, Rachel, Cabona, Lorenzo, Campana, Sergio, Capasso, Giulio, Cappellaro, Enrico, Claudi, Riccardo, Colapietro, Mirko, Cosentino, Rosario, D'Alessio, Francesco, D'Avanzo, Paolo, D'Orsi, Sergio, Della Valle, Massimo, Di Benedetto, Rosario, Di Filippo, Simone, Gal-Yam, Avishay, Genoni, Matteo, Dıaz, Marcos Hernandez, Hershko, Ofir, Kotilainen, Jari, Kuncarayakti, Hanindyo, Landoni, Marco, Causi, Gianluca Li, Marty, Laurent, Mattila, Seppo, Munari, Matteo, Oggioni, Luca, Ventura, Hector Pérez, Pariani, Giorgio, Pignata, Giuliano, Radhakrishnan, Kalyan, Smartt, Stephen, Rappaport, Michael, Riva, Marco, Rubin, Adam, Savarese, Salvatore, Schipani, Pietro, Scuderi, Salvatore, Stritzinger, Maximilian, Vitali, Fabrizio, Young, David, and Sanchez, Ricardo Zanmar
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,D.2.10 - Abstract
The Instrument Control Software of SOXS (Son Of X-Shooter), the forthcoming spectrograph for the ESO New Technology Telescope at the La Silla Observatory, has reached a mature state of development and is approaching the crucial Preliminary Acceptance in Europe phase. Now that all the subsystems have been integrated in the laboratories of the Padova Astronomical Observatory, the team operates for testing purposes with the whole instrument at both engineering and scientific level. These activities will make use of a set of software peculiarities that will be discussed in this contribution. In particular, we focus on the synoptic panel, the co-rotator system special device, on the Active Flexure Compensation system which controls two separate piezo tip-tilt devices., Comment: 6 pages, 3 figures, SPIE conference
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- 2024
30. Decay study of $^{11}$Be with an Optical TPC detector
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Sokołowska, N., Guadilla, V., Mazzocchi, C., Ahmed, R., Borge, M., Cardella, G., Ciemny, A. A., Cosentino, L. G., De Filippo, E., Fedosseev, V., Fijałkowska, A., Fraile, L. M., Geraci, E., Giska, A., Gnoffo, B., Granados, C., Janas, Z., Janiak, Ł., Johnston, K., Kamiński, G., Korgul, A., Kubiela, A., Maiolino, C., Marsh, B., Martorana, N. S., Miernik, K., Molkanov, P., Ovejas, J. D., Pagano, E. V., Pirrone, S., Pomorski, M., Quynh, A. M., Riisager, K., Russo, A., Russotto, P., Świercz, A., Viñals, S., Wilkins, S., and Pfützner, M.
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Nuclear Experiment - Abstract
The $\beta$ decay of one-neutron halo nucleus $^{11}$Be was investigated using the Warsaw Optical Time Projection Chamber (OTPC) detector to measure $\beta$-delayed charged particles. The results of two experiments are reported. In the first one, carried out in LNS Catania, the absolute branching ratio for $\beta$-delayed $\alpha$ emission was measured by counting incoming $^{11}$Be ions stopped in the detector and the observed decays with the emission of $\alpha$ particle. The result of 3.27(46)\% is in good agreement with the literature value. In the second experiment, performed at the HIE-ISOLDE facility at CERN, bunches containing several hundreds of $^{11}$Be ions were implanted into the OTPC detector followed by the detection of decays with the emission of charged particles. The energy spectrum of $\beta$-delayed $\alpha$ particles was determined in the full energy range. It was analysed in the R-matrix framework and was found to be consistent with the literature. The best description of the spectrum was obtained assuming that the two $3/2^+$ and one $1/2^+$ states in $^{11}$B are involved in the transition. The search for $\beta$-delayed emission of protons was undertaken. Only the upper limit for the branching ratio for this process of $(2.2 \pm 0.6_{\rm stat} \pm 0.6_{\rm sys}) \times 10^{-6}$ could be determined. This value is in conflict with the result published in [Ayyad et al. Phys. Rev. Lett. 123, 082501 (2019)] but does agree with the limit reported in [Riisager et al., Eur. Phys. J. A (2020) 56:100], Comment: 16 pages, 18 figures, submitted to Phys. Rev. C
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- 2024
31. Measurement and analysis of the $^{246}$Cm and $^{248}$Cm neutron capture cross-sections at the EAR2 of the n TOF facility
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Alcayne, V., Kimura, A., Mendoza, E., Cano-Ott, D., Aberle, O., Álvarez-Velarde, F., Amaducci, S., Andrzejewski, J., Audouin, L., Bécares, V., Babiano-Suarez, V., Bacak, M., Barbagallo, M., Bečvář, F., Bellia, G., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Busso, M., Caamaño, M., Caballero-Ontanaya, L., Calviño, F., Calviani, M., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Damone, L. A., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fernández-Domınguez, B., Ferrari, A., Finocchiaro, P., Furman, V., Göbel, K., Garg, R., Gawlik-Ramiega, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kivel, N., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, D., Ladarescu, I., Lederer-Woods, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Martınez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mazzone, A., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., de Rada, A. Pérez, Perkowski, J., Persanti, L., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Ramos-Doval, D., Rauscher, T., Reifarth, R., Rochman, D., Romanets, Y., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Talip, T., Tarifeño-Saldivia, A., Tassan-Got, L., Torres-Sánchez, P., Tsinganis, A., Ulrich, J., Urlass, S., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., and Žugec, P.
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Nuclear Experiment - Abstract
The $^{246}$Cm(n,$\gamma$) and $^{248}$Cm(n,$\gamma$) cross-sections have been measured at the Experimental Area 2 (EAR2) of the n_TOF facility at CERN with three C$_6$D$_6$ detectors. This measurement is part of a collective effort to improve the capture cross-section data for Minor Actinides (MAs), which are required to estimate the production and transmutation rates of these isotopes in light water reactors and innovative reactor systems. In particular, the neutron capture in $^{246}$Cm and $^{248}$Cm open the path for the formation of other Cm isotopes and heavier elements such as Bk and Cf and the knowledge of (n,$\gamma$) cross-sections of these Cm isotopes plays an important role in the transport, transmutation and storage of the spent nuclear fuel. The reactions $^{246}$Cm(n,$\gamma$) and $^{248}$Cm(n,$\gamma$) have been the two first capture measurements analyzed at n_TOF EAR2. Until this experiment and two recent measurements performed at J-PARC, there was only one set of data of the capture cross-sections of $^{246}$Cm and $^{248}$Cm, that was obtained in 1969 in an underground nuclear explosion experiment. In the measurement at n_TOF a total of 13 resonances of $^{246}$Cm between 4 and 400 eV and 5 of $^{248}$Cm between 7 and 100 eV have been identified and fitted. The radiative kernels obtained for $^{246}$Cm are compatible with JENDL-5, but some of them are not with JENDL-4, which has been adopted by JEFF-3.3 and ENDF/B-VIII.0. The radiative kernels obtained for the first three $^{248}$Cm resonances are compatible with JENDL-5, however, the other two are not compatible with any other evaluation and are 20% and 60% larger than JENDL-5.
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- 2024
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32. Reasoning in Large Language Models: A Geometric Perspective
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Cosentino, Romain and Shekkizhar, Sarath
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Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
The advancement of large language models (LLMs) for real-world applications hinges critically on enhancing their reasoning capabilities. In this work, we explore the reasoning abilities of large language models (LLMs) through their geometrical understanding. We establish a connection between the expressive power of LLMs and the density of their self-attention graphs. Our analysis demonstrates that the density of these graphs defines the intrinsic dimension of the inputs to the MLP blocks. We demonstrate through theoretical analysis and toy examples that a higher intrinsic dimension implies a greater expressive capacity of the LLM. We further provide empirical evidence linking this geometric framework to recent advancements in methods aimed at enhancing the reasoning capabilities of LLMs.
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- 2024
33. The Mean Longitudinal Magnetic Field and its Uses in Radial-Velocity Surveys
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Rescigno, F., Mortier, A., Dumusque, X., Lakeland, B. S., Haywood, R., Piskunov, N., Nicholson, B. A., López-Morales, M., Dalal, S., Cretignier, M., Klein, B., Cameron, A. Collier, Ghedina, A., Gonzalez, M., Cosentino, R., Sozzetti, A., and Saar, S. H.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
This work focuses on the analysis of the mean longitudinal magnetic field as a stellar activity tracer in the context of small exoplanet detection and characterisation in radial-velocity (RV) surveys. We use SDO/HMI filtergrams to derive Sun-as-a-star magnetic field measurements, and show that the mean longitudinal magnetic field is an excellent rotational period detector and a useful tracer of the solar magnetic cycle. To put these results into context, we compare the mean longitudinal magnetic field to three common activity proxies derived from HARPS-N Sun-as-a-star data: the full-width at half-maximum, the bisector span and the S-index. The mean longitudinal magnetic field does not correlate with the RVs and therefore cannot be used as a one-to-one proxy. However, with high cadence and a long baseline, the mean longitudinal magnetic field outperforms all other considered proxies as a solar rotational period detector, and can be used to inform our understanding of the physical processes happening on the surface of the Sun. We also test the mean longitudinal magnetic field as a "stellar proxy" on a reduced solar dataset to simulate stellar-like observational sampling. With a Gaussian Process regression analysis, we confirm that the solar mean longitudinal magnetic field is the most effective of the considered indicators, and is the most efficient rotational period indicator over different levels of stellar activity. This work highlights the need for polarimetric time series observations of stars., Comment: 23 pages, 27 figures
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- 2024
34. Towards a Personal Health Large Language Model
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Cosentino, Justin, Belyaeva, Anastasiya, Liu, Xin, Furlotte, Nicholas A., Yang, Zhun, Lee, Chace, Schenck, Erik, Patel, Yojan, Cui, Jian, Schneider, Logan Douglas, Bryant, Robby, Gomes, Ryan G., Jiang, Allen, Lee, Roy, Liu, Yun, Perez, Javier, Rogers, Jameson K., Speed, Cathy, Tailor, Shyam, Walker, Megan, Yu, Jeffrey, Althoff, Tim, Heneghan, Conor, Hernandez, John, Malhotra, Mark, Stern, Leor, Matias, Yossi, Corrado, Greg S., Patel, Shwetak, Shetty, Shravya, Zhan, Jiening, Prabhakara, Shruthi, McDuff, Daniel, and McLean, Cory Y.
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Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
In health, most large language model (LLM) research has focused on clinical tasks. However, mobile and wearable devices, which are rarely integrated into such tasks, provide rich, longitudinal data for personal health monitoring. Here we present Personal Health Large Language Model (PH-LLM), fine-tuned from Gemini for understanding and reasoning over numerical time-series personal health data. We created and curated three datasets that test 1) production of personalized insights and recommendations from sleep patterns, physical activity, and physiological responses, 2) expert domain knowledge, and 3) prediction of self-reported sleep outcomes. For the first task we designed 857 case studies in collaboration with domain experts to assess real-world scenarios in sleep and fitness. Through comprehensive evaluation of domain-specific rubrics, we observed that Gemini Ultra 1.0 and PH-LLM are not statistically different from expert performance in fitness and, while experts remain superior for sleep, fine-tuning PH-LLM provided significant improvements in using relevant domain knowledge and personalizing information for sleep insights. We evaluated PH-LLM domain knowledge using multiple choice sleep medicine and fitness examinations. PH-LLM achieved 79% on sleep and 88% on fitness, exceeding average scores from a sample of human experts. Finally, we trained PH-LLM to predict self-reported sleep quality outcomes from textual and multimodal encoding representations of wearable data, and demonstrate that multimodal encoding is required to match performance of specialized discriminative models. Although further development and evaluation are necessary in the safety-critical personal health domain, these results demonstrate both the broad knowledge and capabilities of Gemini models and the benefit of contextualizing physiological data for personal health applications as done with PH-LLM., Comment: 72 pages
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- 2024
35. The PLATO Mission
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Rauer, Heike, Aerts, Conny, Cabrera, Juan, Deleuil, Magali, Erikson, Anders, Gizon, Laurent, Goupil, Mariejo, Heras, Ana, Lorenzo-Alvarez, Jose, Marliani, Filippo, Martin-Garcia, César, Mas-Hesse, J. Miguel, O'Rourke, Laurence, Osborn, Hugh, Pagano, Isabella, Piotto, Giampaolo, Pollacco, Don, Ragazzoni, Roberto, Ramsay, Gavin, Udry, Stéphane, Appourchaux, Thierry, Benz, Willy, Brandeker, Alexis, Güdel, Manuel, Janot-Pacheco, Eduardo, Kabath, Petr, Kjeldsen, Hans, Min, Michiel, Santos, Nuno, Smith, Alan, Suarez, Juan-Carlos, Werner, Stephanie C., Aboudan, Alessio, Abreu, Manuel, a, Lorena Acu, Adams, Moritz, Adibekyan, Vardan, Affer, Laura, Agneray, François, Agnor, Craig, Børsen-Koch, Victor Aguirre, Ahmed, Saad, Aigrain, Suzanne, Al-Bahlawan, Ashraf, Gil, M de los Angeles Alcacera, Alei, Eleonora, Alencar, Silvia, Alexander, Richard, Alfonso-Garzón, Julia, Alibert, Yann, Prieto, Carlos Allende, Almeida, Leonardo, Sobrino, Roi Alonso, Altavilla, Giuseppe, Althaus, Christian, Trujillo, Luis Alonso Alvarez, Amarsi, Anish, Eiff, Matthias Ammler-von, Amôres, Eduardo, Andrade, Laerte, Antoniadis-Karnavas, Alexandros, António, Carlos, del Moral, Beatriz Aparicio, Appolloni, Matteo, Arena, Claudio, Armstrong, David, Aliaga, Jose Aroca, Asplund, Martin, Audenaert, Jeroen, Auricchio, Natalia, Avelino, Pedro, Baeke, Ann, Baillié, Kevin, Balado, Ana, Balagueró, Pau Ballber, Balestra, Andrea, Ball, Warrick, Ballans, Herve, Ballot, Jerome, Barban, Caroline, Barbary, Gaële, Barbieri, Mauro, Forteza, Sebasti Barceló, Barker, Adrian, Barklem, Paul, Barnes, Sydney, Navascues, David Barrado, Barragan, Oscar, Baruteau, Clément, Basu, Sarbani, Baudin, Frederic, Baumeister, Philipp, Bayliss, Daniel, Bazot, Michael, Beck, Paul G., Bedding, Tim, Belkacem, Kevin, Bellinger, Earl, Benatti, Serena, Benomar, Othman, Bérard, Diane, Bergemann, Maria, Bergomi, Maria, Bernardo, Pierre, Biazzo, Katia, Bignamini, Andrea, Bigot, Lionel, Billot, Nicolas, Binet, Martin, Biondi, David, Biondi, Federico, Birch, Aaron C., Bitsch, Bertram, Ceballos, Paz Victoria Bluhm, Bódi, Attila, Bognár, Zsófia, Boisse, Isabelle, Bolmont, Emeline, Bonanno, Alfio, Bonavita, Mariangela, Bonfanti, Andrea, Bonfils, Xavier, Bonito, Rosaria, Bonomo, Aldo Stefano, Börner, Anko, Saikia, Sudeshna Boro, Martín, Elisa Borreguero, Borsa, Francesco, Borsato, Luca, Bossini, Diego, Bouchy, Francois, Boué, Gwenaël, Boufleur, Rodrigo, Boumier, Patrick, Bourrier, Vincent, Bowman, Dominic M., Bozzo, Enrico, Bradley, Louisa, Bray, John, Bressan, Alessandro, Breton, Sylvain, Brienza, Daniele, Brito, Ana, Brogi, Matteo, Brown, Beverly, Brown, David J. A., Brun, Allan Sacha, Bruno, Giovanni, Bruns, Michael, Buchhave, Lars A., Bugnet, Lisa, Buldgen, Gaël, Burgess, Patrick, Busatta, Andrea, Busso, Giorgia, Buzasi, Derek, Caballero, José A., Cabral, Alexandre, Gomez, Juan-Francisco Cabrero, Calderone, Flavia, Cameron, Robert, Cameron, Andrew, Campante, Tiago, Gestal, Néstor Campos, Martins, Bruno Leonardo Canto, Cara, Christophe, Carone, Ludmila, Carrasco, Josep Manel, Casagrande, Luca, Casewell, Sarah L., Cassisi, Santi, Castellani, Marco, Castro, Matthieu, Catala, Claude, Fernández, Irene Catalán, Catelan, Márcio, Cegla, Heather, Cerruti, Chiara, Cessa, Virginie, Chadid, Merieme, Chaplin, William, Charpinet, Stephane, Chiappini, Cristina, Chiarucci, Simone, Chiavassa, Andrea, Chinellato, Simonetta, Chirulli, Giovanni, Christensen-Dalsgaard, Jørgen, Church, Ross, Claret, Antonio, Clarke, Cathie, Claudi, Riccardo, Clermont, Lionel, Coelho, Hugo, Coelho, Joao, Cogato, Fabrizio, Colomé, Josep, Condamin, Mathieu, García, Fernando Conde, Conseil, Simon, Corbard, Thierry, Correia, Alexandre C. M., Corsaro, Enrico, Cosentino, Rosario, Costes, Jean, Cottinelli, Andrea, Covone, Giovanni, Creevey, Orlagh L., Crida, Aurelien, Csizmadia, Szilard, Cunha, Margarida, Curry, Patrick, da Costa, Jefferson, da Silva, Francys, Dalal, Shweta, Damasso, Mario, Damiani, Cilia, Damiani, Francesco, Chagas, Maria Liduina das, Davies, Melvyn, Davies, Guy, Davies, Ben, Davison, Gary, de Almeida, Leandro, de Angeli, Francesca, de Barros, Susana Cristina Cabral, Leão, Izan de Castro, de Freitas, Daniel Brito, de Freitas, Marcia Cristina, De Martino, Domitilla, de Medeiros, José Renan, de Paula, Luiz Alberto, Gómez, Álvaro de Pedraza, de Plaa, Jelle, De Ridder, Joris, Deal, Morgan, Decin, Leen, Deeg, Hans, Innocenti, Scilla Degl, Deheuvels, Sebastien, del Burgo, Carlos, Del Sordo, Fabio, Delgado-Mena, Elisa, Demangeon, Olivier, Denk, Tilmann, Derekas, Aliz, Desert, Jean-Michel, Desidera, Silvano, Dexet, Marc, Di Criscienzo, Marcella, Di Giorgio, Anna Maria, Di Mauro, Maria Pia, Rial, Federico Jose Diaz, Díaz-García, José-Javier, Dima, Marco, Dinuzzi, Giacomo, Dionatos, Odysseas, Distefano, Elisa, Nascimento Jr., Jose-Dias do, Domingo, Albert, D'Orazi, Valentina, Dorn, Caroline, Doyle, Lauren, Duarte, Elena, Ducellier, Florent, Dumaye, Luc, Dumusque, Xavier, Dupret, Marc-Antoine, Eggenberger, Patrick, Ehrenreich, David, Eigmüller, Philipp, Eising, Johannes, Emilio, Marcelo, Eriksson, Kjell, Ermocida, Marco, Giribaldi, Riano Isidoro Escate, Eschen, Yoshi, ez, Lucía Espinosa Yá, Estrela, In s, Evans, Dafydd Wyn, Fabbian, Damian, Fabrizio, Michele, Faria, João Pedro, Farina, Maria, Farinato, Jacopo, Feliz, Dax, Feltzing, Sofia, Fenouillet, Thomas, Fernández, Miguel, Ferrari, Lorenza, Ferraz-Mello, Sylvio, Fialho, Fabio, Fienga, Agnes, Figueira, Pedro, Fiori, Laura, Flaccomio, Ettore, Focardi, Mauro, Foley, Steve, Fontignie, Jean, Ford, Dominic, Fornazier, Karin, Forveille, Thierry, Fossati, Luca, Franca, Rodrigo de Marca, da Silva, Lucas Franco, Frasca, Antonio, Fridlund, Malcolm, Furlan, Marco, Gabler, Sarah-Maria, Gaido, Marco, Gallagher, Andrew, Sempere, Paloma I. Gallego, Galli, Emanuele, García, Rafael A., Hernández, Antonio García, Munoz, Antonio Garcia, García-Vázquez, Hugo, Haba, Rafael Garrido, Gaulme, Patrick, Gauthier, Nicolas, Gehan, Charlotte, Gent, Matthew, Georgieva, Iskra, Ghigo, Mauro, Giana, Edoardo, Gill, Samuel, Girardi, Leo, Winter, Silvia Giuliatti, Giusi, Giovanni, da Silva, João Gomes, Zazo, Luis Jorge Gómez, Gomez-Lopez, Juan Manuel, Hernández, Jonay Isai González, Murillo, Kevin Gonzalez, Melchor, Alejandro Gonzalo, Gorius, Nicolas, Gouel, Pierre-Vincent, Goulty, Duncan, Granata, Valentina, Grenfell, John Lee, bach, Denis Grie, Grolleau, Emmanuel, Grouffal, Salomé, Grziwa, Sascha, Guarcello, Mario Giuseppe, Gueguen, Lo c, Guenther, Eike Wolf, Guilhem, Terrasa, Guillerot, Lucas, Guillot, Tristan, Guiot, Pierre, Guterman, Pascal, Gutiérrez, Antonio, Gutiérrez-Canales, Fernando, Hagelberg, Janis, Haldemann, Jonas, Hall, Cassandra, Handberg, Rasmus, Harrison, Ian, Harrison, Diana L., Hasiba, Johann, Haswell, Carole A., Hatalova, Petra, Hatzes, Artie, Haywood, Raphaelle, Hébrard, Guillaume, Heckes, Frank, Heiter, Ulrike, Hekker, Saskia, Heller, René, Helling, Christiane, Helminiak, Krzysztof, Hemsley, Simon, Heng, Kevin, Herbst, Konstantin, Hermans, Aline, Hermes, JJ, Torres, Nadia Hidalgo, Hinkel, Natalie, Hobbs, David, Hodgkin, Simon, Hofmann, Karl, Hojjatpanah, Saeed, Houdek, Günter, Huber, Daniel, Huesler, Joseph, Hui-Bon-Hoa, Alain, Huygen, Rik, Huynh, Duc-Dat, Iro, Nicolas, Irwin, Jonathan, Irwin, Mike, Izidoro, André, Jacquinod, Sophie, Jannsen, Nicholas Emborg, Janson, Markus, Jeszenszky, Harald, Jiang, Chen, Mancebo, Antonio José Jimenez, Jofre, Paula, Johansen, Anders, Johnston, Cole, Jones, Geraint, Kallinger, Thomas, Kálmán, Szilárd, Kanitz, Thomas, Karjalainen, Marie, Karjalainen, Raine, Karoff, Christoffer, Kawaler, Steven, Kawata, Daisuke, Keereman, Arnoud, Keiderling, David, Kennedy, Tom, Kenworthy, Matthew, Kerschbaum, Franz, Kidger, Mark, Kiefer, Flavien, Kintziger, Christian, Kislyakova, Kristina, Kiss, László, Klagyivik, Peter, Klahr, Hubert, Klevas, Jonas, Kochukhov, Oleg, Köhler, Ulrich, Kolb, Ulrich, Koncz, Alexander, Korth, Judith, Kostogryz, Nadiia, Kovács, Gábor, Kovács, József, Kozhura, Oleg, Krivova, Natalie, Kucinskas, Arunas, Kuhlemann, Ilyas, Kupka, Friedrich, Laauwen, Wouter, Labiano, Alvaro, Lagarde, Nadege, Laget, Philippe, Laky, Gunter, Lam, Kristine Wai Fun, Lambrechts, Michiel, Lammer, Helmut, Lanza, Antonino Francesco, Lanzafame, Alessandro, Martiz, Mariel Lares, Laskar, Jacques, Latter, Henrik, Lavanant, Tony, Lawrenson, Alastair, Lazzoni, Cecilia, Lebre, Agnes, Lebreton, Yveline, Etangs, Alain Lecavelier des, Lee, Katherine, Leinhardt, Zoe, Leleu, Adrien, Lendl, Monika, Leto, Giuseppe, Levillain, Yves, Libert, Anne-Sophie, Lichtenberg, Tim, Ligi, Roxanne, Lignieres, Francois, Lillo-Box, Jorge, Linsky, Jeffrey, Liu, John Scige, Loidolt, Dominik, Longval, Yuying, Lopes, Ilídio, Lorenzani, Andrea, Ludwig, Hans-Guenter, Lund, Mikkel, Lundkvist, Mia Sloth, Luri, Xavier, Maceroni, Carla, Madden, Sean, Madhusudhan, Nikku, Maggio, Antonio, Magliano, Christian, Magrin, Demetrio, Mahy, Laurent, Maibaum, Olaf, Malac-Allain, LeeRoy, Malapert, Jean-Christophe, Malavolta, Luca, Maldonado, Jesus, Mamonova, Elena, Manchon, Louis, Manjón, Andres, Mann, Andrew, Mantovan, Giacomo, Marafatto, Luca, Marconi, Marcella, Mardling, Rosemary, Marigo, Paola, Marinoni, Silvia, Marques, rico, Marques, Joao Pedro, Marrese, Paola Maria, Marshall, Douglas, Perales, Silvia Martínez, Mary, David, Marzari, Francesco, Masana, Eduard, Mascher, Andrina, Mathis, Stéphane, Mathur, Savita, Vodopivec, Iris Martín, Figueiredo, Ana Carolina Mattiuci, Maxted, Pierre F. L., Mazeh, Tsevi, Mazevet, Stephane, Mazzei, Francesco, McCormac, James, McMillan, Paul, Menou, Lucas, Merle, Thibault, Meru, Farzana, Mesa, Dino, Messina, Sergio, Mészáros, Szabolcs, Meunier, Nadége, Meunier, Jean-Charles, Micela, Giuseppina, Michaelis, Harald, Michel, Eric, Michielsen, Mathias, Michtchenko, Tatiana, Miglio, Andrea, Miguel, Yamila, Milligan, David, Mirouh, Giovanni, Mitchell, Morgan, Moedas, Nuno, Molendini, Francesca, Molnár, László, Mombarg, Joey, Montalban, Josefina, Montalto, Marco, Monteiro, Mário J. P. F. G., Sánchez, Francisco Montoro, Morales, Juan Carlos, Morales-Calderon, Maria, Morbidelli, Alessandro, Mordasini, Christoph, Moreau, Chrystel, Morel, Thierry, Morello, Guiseppe, Morin, Julien, Mortier, Annelies, Mosser, Beno t, Mourard, Denis, Mousis, Olivier, Moutou, Claire, Mowlavi, Nami, Moya, Andrés, Muehlmann, Prisca, Muirhead, Philip, Munari, Matteo, Musella, Ilaria, Mustill, Alexander James, Nardetto, Nicolas, Nardiello, Domenico, Narita, Norio, Nascimbeni, Valerio, Nash, Anna, Neiner, Coralie, Nelson, Richard P., Nettelmann, Nadine, Nicolini, Gianalfredo, Nielsen, Martin, Niemi, Sami-Matias, Noack, Lena, Noels-Grotsch, Arlette, Noll, Anthony, Norazman, Azib, Norton, Andrew J., Nsamba, Benard, Ofir, Aviv, Ogilvie, Gordon, Olander, Terese, Olivetto, Christian, Olofsson, Göran, Ong, Joel, Ortolani, Sergio, Oshagh, Mahmoudreza, Ottacher, Harald, Ottensamer, Roland, Ouazzani, Rhita-Maria, Paardekooper, Sijme-Jan, Pace, Emanuele, Pajas, Miriam, Palacios, Ana, Palandri, Gaelle, Palle, Enric, Paproth, Carsten, Parro, Vanderlei, Parviainen, Hannu, Granado, Javier Pascual, Passegger, Vera Maria, Pastor-Morales, Carmen, Pätzold, Martin, Pedersen, May Gade, Hidalgo, David Pena, Pepe, Francesco, Pereira, Filipe, Persson, Carina M., Pertenais, Martin, Peter, Gisbert, Petit, Antoine C., Petit, Pascal, Pezzuto, Stefania, Pichierri, Gabriele, Pietrinferni, Adriano, Pinheiro, Fernando, Pinsonneault, Marc, Plachy, Emese, Plasson, Philippe, Plez, Bertrand, Poppenhaeger, Katja, Poretti, Ennio, Portaluri, Elisa, Portell, Jordi, de Mello, Gustavo Frederico Porto, Poyatos, Julien, Pozuelos, Francisco J., Moroni, Pier Giorgio Prada, Pricopi, Dumitru, Prisinzano, Loredana, Quade, Matthias, Quirrenbach, Andreas, Reina, Julio Arturo Rabanal, Soares, Maria Cristina Rabello, Raimondo, Gabriella, Rainer, Monica, Rodón, Jose Ramón, Ramón-Ballesta, Alejandro, Zapata, Gonzalo Ramos, Rätz, Stefanie, Rauterberg, Christoph, Redman, Bob, Redmer, Ronald, Reese, Daniel, Regibo, Sara, Reiners, Ansgar, Reinhold, Timo, Renie, Christian, Ribas, Ignasi, Ribeiro, Sergio, Ricciardi, Thiago Pereira, Rice, Ken, Richard, Olivier, Riello, Marco, Rieutord, Michel, Ripepi, Vincenzo, Rixon, Guy, Rockstein, Steve, Ortiz, José Ramón Rodón, Rodríguez, María Teresa Rodrigo, Amor, Alberto Rodríguez, Díaz, Luisa Fernanda Rodríguez, Garcia, Juan Pablo Rodriguez, Rodriguez-Gomez, Julio, Roehlly, Yannick, Roig, Fernando, Rojas-Ayala, Bárbara, Rolf, Tobias, Rørsted, Jakob Lysgaard, Rosado, Hugo, Rosotti, Giovanni, Roth, Olivier, Roth, Markus, Rousseau, Alex, Roxburgh, Ian, Roy, Fabrice, Royer, Pierre, Ruane, Kirk, Mastropasqua, Sergio Rufini, de Galarreta, Claudia Ruiz, Russi, Andrea, Saar, Steven, Saillenfest, Melaine, Salaris, Maurizio, Salmon, Sebastien, Saltas, Ippocratis, Samadi, Réza, Samadi, Aunia, Samra, Dominic, da Silva, Tiago Sanches, Carrasco, Miguel Andrés Sánchez, Santerne, Alexandre, Pé, Amaia Santiago, Santoli, Francesco, Santos, ngela R. G., Mesa, Rosario Sanz, Sarro, Luis Manuel, Scandariato, Gaetano, Schäfer, Martin, Schlafly, Edward, Schmider, François-Xavier, Schneider, Jean, Schou, Jesper, Schunker, Hannah, Schwarzkopf, Gabriel Jörg, Serenelli, Aldo, Seynaeve, Dries, Shan, Yutong, Shapiro, Alexander, Shipman, Russel, Sicilia, Daniela, sanmartin, Maria Angeles Sierra, Sigot, Axelle, Silliman, Kyle, Silvotti, Roberto, Simon, Attila E., Napoli, Ricardo Simoyama, Skarka, Marek, Smalley, Barry, Smiljanic, Rodolfo, Smit, Samuel, Smith, Alexis, Smith, Leigh, Snellen, Ignas, Sódor, Ádám, Sohl, Frank, Solanki, Sami K., Sortino, Francesca, Sousa, Sérgio, Southworth, John, Souto, Diogo, Sozzetti, Alessandro, Stamatellos, Dimitris, Stassun, Keivan, Steller, Manfred, Stello, Dennis, Stelzer, Beate, Stiebeler, Ulrike, Stokholm, Amalie, Storelvmo, Trude, Strassmeier, Klaus, Strøm, Paul Anthony, Strugarek, Antoine, Sulis, Sophia, vanda, Michal, Szabados, László, Szabó, Róbert, Szabó, Gyula M., Szuszkiewicz, Ewa, Talens, Geert Jan, Teti, Daniele, Theisen, Tom, Thévenin, Frédéric, Thoul, Anne, Tiphene, Didier, Titz-Weider, Ruth, Tkachenko, Andrew, Tomecki, Daniel, Tonfat, Jorge, Tosi, Nicola, Trampedach, Regner, Traven, Gregor, Triaud, Amaury, Trønnes, Reidar, Tsantaki, Maria, Tschentscher, Matthias, Turin, Arnaud, Tvaruzka, Adam, Ulmer, Bernd, Ulmer-Moll, Solène, Ulusoy, Ceren, Umbriaco, Gabriele, Valencia, Diana, Valentini, Marica, Valio, Adriana, Guijarro, Ángel Luis Valverde, Van Eylen, Vincent, Van Grootel, Valerie, van Kempen, Tim A., Van Reeth, Timothy, Van Zelst, Iris, Vandenbussche, Bart, Vasiliou, Konstantinos, Vasilyev, Valeriy, de Mascarenhas, David Vaz, Vazan, Allona, Nunez, Marina Vela, Velloso, Eduardo Nunes, Ventura, Rita, Ventura, Paolo, Venturini, Julia, Trallero, Isabel Vera, Veras, Dimitri, Verdugo, Eva, Verma, Kuldeep, Vibert, Didier, Martinez, Tobias Vicanek, Vida, Krisztián, Vigan, Arthur, Villacorta, Antonio, Villaver, Eva, Aparicio, Marcos Villaverde, Viotto, Valentina, Vorobyov, Eduard, Vorontsov, Sergey, Wagner, Frank W., Walloschek, Thomas, Walton, Nicholas, Walton, Dave, Wang, Haiyang, Waters, Rens, Watson, Christopher, Wedemeyer, Sven, Weeks, Angharad, Weingrill, Jörg, Weiss, Annita, Wendler, Belinda, West, Richard, Westerdorff, Karsten, Westphal, Pierre-Amaury, Wheatley, Peter, White, Tim, Whittaker, Amadou, Wickhusen, Kai, Wilson, Thomas, Windsor, James, Winter, Othon, Winther, Mark Lykke, Winton, Alistair, Witteck, Ulrike, Witzke, Veronika, Woitke, Peter, Wolter, David, Wuchterl, Günther, Wyatt, Mark, Yang, Dan, Yu, Jie, Sanchez, Ricardo Zanmar, Osorio, María Rosa Zapatero, Zechmeister, Mathias, Zhou, Yixiao, Ziemke, Claas, and Zwintz, Konstanze
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.
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- 2024
36. Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement: CHRONIC LYMPHOCYTIC LEUKEMIA
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Nabki, Jana, Al Deeban, Bashar, Sium, Abel Mehari, Cosentino, Chiara, Almasri, Mohammad, Awikeh, Bassel, Maher, Nawar, Bellia, Matteo, Dondolin, Riccardo, Mouhssine, Samir, Talotta, Donatella, Secomandi, Eleonora, Kogila, Sreekar, Ghanej, Joseph, Maiellaro, Francesca, Cividini, Luca, Rasi, Silvia, Chiarenza, Annalisa, Olivieri, Jacopo, Gentile, Massimo, Zaja, Francesco, Del Principe, Maria Ilaria, Laurenti, Luca, Bomben, Riccardo, Vit, Filippo, Bittolo, Tamara, Zucchetto, Antonella, Gattei, Valter, Gaidano, Gianluca, and Moia, Riccardo
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- 2024
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37. Medical treatment before in-vitro fertilization in patients with adenomyosis: a systematic review and meta-analysis
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Galati, Giulia, Olivieri, Carlotta, Cosentino, Martina, Azenkoud, Ilham, Cugini, Sara, Sorrenti, Giuseppe, Rizzo, Giuseppe, and Muzii, Ludovico
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- 2024
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38. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
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Beaver, Alexander K., Keneskhanova, Zhibek, Cosentino, Raúl O., Weiss, Brian L., Awuoche, Erick O., Smallenberger, Gretchen M., Buenconsejo, Gracyn Y., Crilly, Nathan P., Smith, Jaclyn E., Hakim, Jill M. C., Zhang, Bailin, Bobb, Bryce, Rijo-Ferreira, Filipa, Figueiredo, Luisa M., Aksoy, Serap, Siegel, T. Nicolai, and Mugnier, Monica R.
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- 2024
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39. Primary colonization and small-scale dynamics of non-indigenous benthic species: a case study
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Giacobbe, Salvatore, Andrea, Cosentino, and Antonietta, Rosso
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- 2024
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40. A reduction in tumor volume exceeding 65% predicts a good histological response to neoadjuvant chemotherapy in patients with Ewing sarcoma
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Aso, Ayano, Aiba, Hisaki, Traversari, Matteo, Righi, Alberto, Gambarotti, Marco, Atherley O’Meally, Ahmed, Solou, Konstantina, Cammelli, Silvia, Bordini, Barbara, Cosentino, Monica, Zuccheri, Federica, Dozza, Barbara, Frega, Giorgio, Ibrahim, Toni, Manfrini, Marco, Donati, Davide Maria, and Errani, Costantino
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- 2024
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41. Exploiting Large Language Models for Enhanced Review Classification Explanations Through Interpretable and Multidimensional Analysis
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Cosentino, Cristian, Gündüz-Cüre, Merve, Marozzo, Fabrizio, Öztürk-Birim, Şule, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Pedreschi, Dino, editor, Monreale, Anna, editor, Guidotti, Riccardo, editor, Pellungrini, Roberto, editor, and Naretto, Francesca, editor
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- 2025
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42. The GAPS programme at TNG. LVII. TOI-5076b: A warm sub-Neptune planet orbiting a thin-to-thick-disk transition star in a wide binary system
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Montalto, M., Greco, N., Biazzo, K., Desidera, S., Andreuzzi, G., Bieryla, A., Bignamini, A., Bonomo, A. S., Briceño, C., Cabona, L., Cosentino, R., Damasso, M., Fiorenzano, A., Fong, W., Goeke, B., Hesse, K. M., Kostov, V. B., Lanza, A. F., Latham, D. W., Law, N., Mancini, L., Maggio, A., Molinaro, M., Mann, A. W., Mantovan, G., Naponiello, L., Nardiello, D., Nascimbeni, V., Pagano, I., Pedani, M., Safonov, B. S., Scandariato, G., Seager, S., Singh, V., Sozzetti, A., Strakhov, I. A., Winn, J. N., Ziegler, C., and Zingales, T.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims. We report the confirmation of a new transiting exoplanet orbiting the star TOI-5076. Methods. We present our vetting procedure and follow-up observations which led to the confirmation of the exoplanet TOI-5076b. In particular, we employed high-precision {\it TESS} photometry, high-angular-resolution imaging from several telescopes, and high-precision radial velocities from HARPS-N. Results. From the HARPS-N spectroscopy, we determined the spectroscopic parameters of the host star: T$\rm_{eff}$=(5070$\pm$143) K, log~g=(4.6$\pm$0.3), [Fe/H]=(+0.20$\pm$0.08), and [$\alpha$/Fe]=0.05$\pm$0.06. The transiting planet is a warm sub-Neptune with a mass m$\rm_p=$(16$\pm$2) M$\rm_{\oplus}$, a radius r$\rm_p=$(3.2$\pm$0.1)~R$\rm_{\oplus}$ yielding a density $\rho_p$=(2.8$\pm$0.5) g cm$^{-3}$. It revolves around its star approximately every 23.445 days. Conclusions. The host star is a metal-rich, K2V dwarf, located at about 82 pc from the Sun with a radius of R$_{\star}$=(0.78$\pm$0.01) R$_{\odot}$ and a mass of M$_{\star}$=(0.80$\pm$0.07) M$_{\odot}$. It forms a common proper motion pair with an M-dwarf companion star located at a projected separation of 2178 au. The chemical analysis of the host-star and the Galactic-space velocities indicate that TOI-5076 belongs to the old population of thin-to-thick-disk transition stars. The density of TOI-5076b suggests the presence of a large fraction by volume of volatiles overlying a massive core. We found that a circular orbit solution is marginally favored with respect to an eccentric orbit solution for TOI-5076b., Comment: Accepted by Astronomy & Astrophysics: 15 pages, 19 figures, 4 tables
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- 2024
43. Improving Earth-like planet detection in radial velocity using deep learning
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Zhao, Yinan, Dumusque, Xavier, Cretignier, Michael, Cameron, Andrew Collier, Latham, David W., López-Morales, Mercedes, Mayor, Michel, Sozzetti, Alessandro, Cosentino, Rosario, Gómez-Vargas, Isidro, Pepe, Francesco, and Udry, Stephane
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Computer Science - Machine Learning - Abstract
Many novel methods have been proposed to mitigate stellar activity for exoplanet detection as the presence of stellar activity in radial velocity (RV) measurements is the current major limitation. Unlike traditional methods that model stellar activity in the RV domain, more methods are moving in the direction of disentangling stellar activity at the spectral level. The goal of this paper is to present a novel convolutional neural network-based algorithm that efficiently models stellar activity signals at the spectral level, enhancing the detection of Earth-like planets. We trained a convolutional neural network to build the correlation between the change in the spectral line profile and the corresponding RV, full width at half maximum (FWHM) and bisector span (BIS) values derived from the classical cross-correlation function. This algorithm has been tested on three intensively observed stars: Alpha Centauri B (HD128621), Tau ceti (HD10700), and the Sun. By injecting simulated planetary signals at the spectral level, we demonstrate that our machine learning algorithm can achieve, for HD128621 and HD10700, a detection threshold of 0.5 m/s in semi-amplitude for planets with periods ranging from 10 to 300 days. This threshold would correspond to the detection of a $\sim$4$\mathrm{M}_{\oplus}$ in the habitable zone of those stars. On the HARPS-N solar dataset, our algorithm is even more efficient at mitigating stellar activity signals and can reach a threshold of 0.2 m/s, which would correspond to a 2.2$\mathrm{M}_{\oplus}$ planet on the orbit of the Earth. To the best of our knowledge, it is the first time that such low detection thresholds are reported for the Sun, but also for other stars, and therefore this highlights the efficiency of our convolutional neural network-based algorithm at mitigating stellar activity in RV measurements., Comment: Accepted for publication in A&A
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- 2024
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44. Observations of Titan's Stratosphere During Northern Summer: Temperatures, CH3CN and CH3D Abundances
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Thelen, Alexander E., Nixon, Conor A., Cordiner, Martin A., Lellouch, Emmanuel, Vinatier, Sandrine, Teanby, Nicholas A., Butler, Bryan, Charnley, Steven B., Cosentino, Richard G., de Kleer, Katherine, Irwin, Patrick G. J., Gurwell, Mark A., Kisiel, Zbigniew, and Moreno, Raphael
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Titan's atmospheric composition and dynamical state have previously been studied over numerous epochs by both ground- and space-based facilities. However, stratospheric measurements remain sparse during Titan's northern summer and fall. The lack of seasonal symmetry in observations of Titan's temperature field and chemical abundances raises questions about the nature of the middle atmosphere's meridional circulation and evolution over Titan's 29-yr seasonal cycle that can only be answered through long-term monitoring campaigns. Here, we present maps of Titan's stratospheric temperature, acetonitrile (or methyl cyanide; CH$_3$CN), and monodeuterated methane (CH$_3$D) abundances following Titan's northern summer solstice obtained with Band 9 ($\sim0.43$ mm) ALMA observations. We find that increasing temperatures towards high-southern latitudes, currently in winter, resemble those observed during Titan's northern winter by the Cassini mission. Acetonitrile abundances have changed significantly since previous (sub)millimeter observations, and we find that the species is now highly concentrated at high-southern latitudes. The stratospheric CH$_3$D content is found to range between 4-8 ppm in these observations, and we infer the CH$_4$ abundance to vary between $\sim0.9-1.6\%$ through conversion with previously measured D/H values. A global value of CH$_4=1.15\%$ was retrieved, lending further evidence to the temporal and spatial variability of Titan's stratospheric methane when compared with previous measurements. Additional observations are required to determine the cause and magnitude of stratospheric enhancements in methane during these poorly understood seasons on Titan., Comment: Accepted for publication in the Planetary Science Journal. 9 Figures, 1 table
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- 2024
45. The GAPS Programme at TNG. XXX: Characterization of the low-density gas giant HAT-P-67 b with GIARPS
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Sicilia, D., Scandariato, G., Guilluy, G., Esposito, M., Borsa, F., Stangret, M., Di Maio, C., Lanza, A. F., Bonomo, A. S., Desidera, S., Fossati, L., Nardiello, D., Sozzetti, A., Malavolta, L., Nascimbeni, V., Rainer, M., D'Arpa, M. C., Mancini, L., Singh, V., Zingales, T., Affer, L., Bignamini, A., Claudi, R., Colombo, S., Cosentino, R., Ghedina, A., Micela, G., Molinari, E., Molinaro, M., Pagano, I., and Piotto, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
HAT-P-67 b is one of the lowest-density gas giants known to date, making it an excellent target for atmospheric characterization through the transmission spectroscopy technique. In the framework of the GAPS large programme, we collected four transit events, with the aim of studying the exoplanet atmosphere and deriving the orbital projected obliquity. We exploited the high-precision GIARPS observing mode of the TNG, along with additional archival TESS photometry, to explore the activity level of the host star. We performed transmission spectroscopy, both in the VIS and in the nIR wavelength range, and analysed the RML effect both fitting the RVs and the Doppler shadow. Based on the TESS photometry, we redetermined the transit parameters of HAT-P-67 b. By modelling the RML effect, we derived a sky-projected obliquity of ($2.2\pm0.4$){\deg} indicating an aligned planetary orbit. The chromospheric activity index $\log\,R^{\prime}_{\rm HK}$, the CCF profile, and the variability in the transmission spectrum of the H$\alpha$ line suggest that the host star shows signatures of stellar activity and/or pulsations. We found no evidence of atomic or molecular species in the VIS transmission spectra, with the exception of pseudo-signals corresponding to Cr I, Fe I, H$\alpha$, Na I, and Ti I. In the nIR range, we found an absorption signal of the He I triplet of 5.56$^{+0.29}_{-0.30}$%(19.0$\sigma$), corresponding to an effective planetary radius of $\sim$3$R_p$ (where $R_p\sim$2$R_J$) which extends beyond the planet's Roche Lobe radius. Owing to the stellar variability, together with the high uncertainty of the model, we could not confirm the planetary origin of the signals found in the optical transmission spectrum. On the other hand, we confirmed previous detections of the infrared He I triplet, providing a 19.0$\sigma$ detection. Our finding indicates that the planet's atmosphere is evaporating., Comment: Accepted for publication in A&A
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- 2024
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46. Confronting compositional confusion through the characterisation of the sub-Neptune orbiting HD 77946
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Palethorpe, L., John, A. Anna, Mortier, A., Davoult, J., Wilson, T. G., Rice, K., Cameron, A. C., Alibert, Y., Buchhave, L. A., Malavolta, L., Cadman, J., López-Morales, M., Dumusque, X., Silva, A. M., Quinn, S. N., Van Eylen, V., Vissapragada, S., Affer, L., Charbonneau, D., Cosentino, R., Ghedina, A., Haywood, R. D., Latham, D. W., Lienhard, F., Fiorenzano, A. F. Martínez, Pedani, M., Pepe, F., Pinamonti, M., Sozzetti, A., Stalport, M., Udry, S., and Vanderburg, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report on the detailed characterization of the HD 77946 planetary system. HD 77946 is an F5 ($M_*$ = 1.17 M$_{\odot}$, $R_*$ = 1.31 R$_{\odot}$) star, which hosts a transiting planet recently discovered by NASA's Transiting Exoplanet Survey Satellite (TESS), classified as TOI-1778 b. Using TESS photometry, high-resolution spectroscopic data from HARPS-N, and photometry from CHEOPS, we measure the radius and mass from the transit and RV observations, and find that the planet, HD 77946 b, orbits with period $P_{\rm b}$ = $6.527282_{-0.000020}^{+0.000015}$ d, has a mass of $M_{\rm b} = 8.38\pm{1.32}$M$_\oplus$, and a radius of $R_{\rm b} = 2.705_{-0.081}^{+0.086}$R$_\oplus$. From the combination of mass and radius measurements, and the stellar chemical composition, the planet properties suggest that HD 77946 b is a sub-Neptune with a $\sim$1\% H/He atmosphere. However, a degeneracy still exists between water-world and silicate/iron-hydrogen models, and even though interior structure modelling of this planet favours a sub-Neptune with a H/He layer that makes up a significant fraction of its radius, a water-world composition cannot be ruled out, as with $T_{\rm eq} = 1248^{+40}_{-38}~$K, water may be in a supercritical state. The characterisation of HD 77946 b, adding to the small sample of well-characterised sub-Neptunes, is an important step forwards on our journey to understanding planetary formation and evolution pathways. Furthermore, HD 77946 b has one of the highest transmission spectroscopic metrics for small planets orbiting hot stars, thus transmission spectroscopy of this key planet could prove vital for constraining the compositional confusion that currently surrounds small exoplanets., Comment: 19 pages, 13 figures, 5 tables. Published in MNRAS
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- 2024
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47. The Core Mass Function Across Galactic Environments. IV. The Galactic Center
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Kinman, Alva V. I., Petkova, Maya A., Tan, Jonathan C., Cosentino, Giuliana, and Cheng, Yu
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Astrophysics - Astrophysics of Galaxies - Abstract
The origin of the stellar Initial Mass Function (IMF) and how it may vary with galactic environment is a matter of debate. Certain star formation theories involve a close connection between the IMF and the Core Mass Function (CMF) so it is important to measure this CMF in a range of Milky Way locations. Here we study the CMF of three Galactic Center clouds: G0.253+0.016 ("The Brick"), Sgr B2 (Deep South field) and Sgr C. We use ALMA 1 mm continuum images and identify cores as peaks in thermal dust emission via the dendrogram algorithm. We develop a completeness correction method via synthetic core insertion, utilizing a realistic mass-dependent size distribution. A power law $\text{d}N/\text{d}\log M \propto M^{-\alpha}$ is fit to the CMFs $>2\:M_\odot$. The Brick has a Salpeter-like index $\alpha=1.28\pm0.09$, while the other regions have shallower indices: Sgr C has $\alpha=0.99\pm0.06$; Sgr B2-DS has $\alpha=0.70\pm0.03$. When smoothed to a common resolution, the differences between the Brick and the others increase as we obtain $\alpha=1.36\pm0.12$, $\alpha=0.66\pm0.06$ and $\alpha=0.62\pm0.04$, respectively, for masses $\gtrsim3\:M_\odot$. Furthermore, we analyze the spatial distribution and mass segregation of cores: Sgr C and Sgr B2-DS show signs of mass segregation, but the Brick does not. We compare our results to several other CMFs from different Galactic regions derived with the same methods. Finally, we discuss how our results may help define an evolutionary sequence of star cluster formation and be used to test star formation theories., Comment: Accepted for publication in ApJ. 28 pages, 15 figures
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- 2024
48. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Planetary and Cometary Atmospheres
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Cordiner, Martin A., Thelen, Alexander E., Cavalié, Thibault, Cosentino, Richard, Fletcher, Leigh N., Gurwell, Mark, de Kleer, Katherine, Kuan, Yi-Jehng, Lellouch, Emmanuel, Moullet, Arielle, Nixon, Conor, de Pater, Imke, Teanby, Nicholas A., Butler, Bryan, Charnley, Steven, Moreno, Raphael, Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Maccarone, Thomas J., Saintonge, Amélie, Smith, Matthew, and Wedemeyer, Sven
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution the Earth and other planets. Compositional and meteorological studies of the giant planets provide a foundation for understanding the nature of the most commonly observed exoplanets, while spectroscopic observations of the atmospheres of terrestrial planets, moons, and comets provide insights into the past and present-day habitability of planetary environments, and the availability of the chemical ingredients for life. While prior and existing (sub)millimeter observations have led to major advances in these areas, progress is hindered by limitations in the dynamic range, spatial and temporal coverage, as well as sensitivity of existing telescopes and interferometers. Here, we summarize some of the key planetary science use cases that factor into the design of the Atacama Large Aperture Submillimeter Telescope (AtLAST), a proposed 50-m class single dish facility: (1) to more fully characterize planetary wind fields and atmospheric thermal structures, (2) to measure the compositions of icy moon atmospheres and plumes, (3) to obtain detections of new, astrobiologically relevant gases and perform isotopic surveys of comets, and (4) to perform synergistic, temporally-resolved measurements in support of dedicated interplanetary space missions. The improved spatial coverage (several arcminutes), resolution ($\sim1.2''-12''$), bandwidth (several tens of GHz), dynamic range ($\sim10^5$) and sensitivity ($\sim1$ mK km s$^{-1}$) required by these science cases would enable new insights into the chemistry and physics of planetary environments, the origins of prebiotic molecules and the habitability of planetary systems in general., Comment: Submitted to Open Research Europe (AtLAST collection). 19 pages
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- 2024
49. The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.
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Benatar, Michael, Wuu, Joanne, Huey, Edward, McMillan, Corey, Petersen, Ronald, Postuma, Ronald, McHutchison, Caroline, Dratch, Laynie, Arias, Jalayne, Crawley, Anita, Houlden, Henry, McDermott, Michael, Cai, Xueya, Thakur, Neil, Boxer, Adam, Rosen, Howard, Boeve, Bradley, Dacks, Penny, Cosentino, Stephanie, Abrahams, Sharon, Shneider, Neil, Lingor, Paul, Shefner, Jeremy, Andersen, Peter, Al-Chalabi, Ammar, and Turner, Martin
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Humans ,Amyotrophic Lateral Sclerosis ,Phenotype ,Frontotemporal Dementia ,Neurodegenerative Diseases ,Biomarkers - Abstract
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers. The Miami Framework, emerging from discussions at the Second International Pre-Symptomatic ALS Workshop in Miami (February 2023; a full list of attendees and their affiliations appears in the Supplementary Information) proposes a classification system built on: first, three parallel phenotypic axes - motor neuron, frontotemporal and extrapyramidal - rather than the unitary approach of combining all phenotypic elements into a single clinical entity; and second, biomarkers that reflect different aspects of the underlying pathology and biology of neurodegeneration. This framework decouples clinical syndromes from biomarker evidence of disease and builds on experiences from other neurodegenerative diseases to offer a unified approach to specifying the pleiotropic clinical manifestations of disease and describing the trajectory of emergent biomarkers.
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- 2024
50. Split syndrome with acute-onset hemichorea and contralateral progressive parkinsonism: a case report
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Cammarota, Francescantonio, Tassorelli, Cristina, Cosentino, Giuseppe, Pichiecchio, Anna, and Todisco, Massimiliano
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- 2024
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