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15 results on '"Costa, Ryan Santos"'

1. Impact of FOXP3 gene polymorphisms and gene-environment interactions in asthma and atopy in a Brazilian population

Author

Marques, Cintia Rodrigues, primary, Fiuza, Bianca Sampaio Dotto, additional, da Silva, Thiago Magalhães, additional, Carneiro, Tamires Cana Brasil, additional, Costa, Ryan Santos, additional, de Assis Silva, Monica Francisca, additional, Viana, Wagma Lauane Luz, additional, Carneiro, Valdirene Leão, additional, Alcantara-Neves, Neuza Maria, additional, Barreto, Maurício Lima, additional, and Figueiredo, Camila Alexandrina, additional

Published
2022
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5. Hippocampus reidi, a Marine Natural Product Reduces TH2 Cytokine Levels and Attenuates NF-KB Expression

Author

Ferreira Silva, Hugo Bernardino, primary, Silva, Raimon RIOS, additional, Queiroz Carneiro, Norma Vilany, additional, Pires, Anaque Oliveira, additional, Serafim Machado, Marta Santos, additional, Marques, Cíntia Rodrigues, additional, Costa, Ryan Santos, additional, Brasil, Tamires Carneiro, additional, Pessoa ALBUQUERQUE Filho, Paulo, additional, Franco, Eryvelton Souza, additional, Souza Maia, Maria Bernadete, additional, Silveira, Rosana Beatriz, additional, Alcântara-Neves, Neuza Maria, additional, and Figueiredo, Camila Alexandrina, additional

Published
2017
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7. Anti-inflammatory Activity of Jurubeba (Solanum paniculatum L.) Through Reducing the T-bet and GATA3 Gene Expression, In Vitro

Author

Rios, Raimon, primary, Ferreira Silva, Hugo Bernardino, additional, Queiroz Carneiro, Norma Vilany, additional, Costa, Ryan Santos, additional, Brasil Carneiro, Tamires Cana, additional, Marques, Cíntia Rodrigues, additional, Serafim Machado, Marta Santos, additional, Velozo, Eudes Silva, additional, Silva, Telma M.G., additional, Sarmento Silva, Tania Maria, additional, Conceição, Adilva Souza, additional, Alcântara-Neves, Neuza Maria, additional, and Figueiredo, Camila Alexandrina, additional

Published
2017
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9. Variants in OXA1L Gene Are Associated With Asthma And Atopy in a Latin Population

Author

Pires, Anaque Oliveira, primary, Silva, Milca Jesus, additional, Rabelo Santana, Maria Borges, additional, Silva, Raimon Rios, additional, Ferreira Silva, Hugo Bernardino, additional, Queiroz Carneiro, Norma Vilany, additional, Queiroz, Gerson Almeida, additional, Fonseca, Héllen Freitas, additional, Dias, Sandro Oliveira, additional, Costa, Ryan Santos, additional, Barreto, Mauricio Lima, additional, and Figueiredo, Camila Alexandrina, additional

Published
2017
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10. Transforming Growth Factor-Beta 1 (TGF-Beta 1) Gene Polymorphisms are Associated with Atopic Asthma and Helminth Infections in an Admixed Population

Author

Costa, Ryan Santos, primary, Figueiredo, Camila Alexandrina, additional, Barreto, Mauricio Lima, additional, Alcântara-Neves, Neuza Maria, additional, Rodrigues, Laura, additional, Cruz, Álvaro, additional, Pontes-de-Carvalho, Lain, additional, Vergara, Candelaria, additional, Rafaels, Nicholas M., additional, Foster, Cassandra, additional, Potee, Joseph, additional, Campbell, Monica, additional, Mathias, Rasika A., additional, and Barnes, Kathleen C., additional

Published
2017
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11. IL1RL1 Variants rs1041973 and rs873022 are Associated With Allergy Markers and Soluble ST2 Production in a Brazilian Population

Author

Queiroz, Gerson Almeida, primary, Costa, Ryan Santos, additional, Carneiro, Valdirene Leao, additional, Jesus, Talita Santos, additional, Alcântara-Neves, Neuza Maria, additional, Pires, Anaque Oliveira, additional, Fonseca, Héllen Freitas, additional, Barreto, Mauricio Lima, additional, and Figueiredo, Camila Alexandrina, additional

Published
2017
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12. Genetic and epigenetic studies of FOXP3 in asthma and allergy

Author

Marques, Cintia Rodrigues, primary, Costa, Ryan Santos, additional, Costa, Gustavo Nunes de Oliveira, additional, da Silva, Thiago Magalhães, additional, Teixeira, Tatiane Oliveira, additional, de Andrade, Emília Maria Medeiros, additional, Galvão, Alana A., additional, Carneiro, Valdirene Leão, additional, and Figueiredo, Camila Alexandrina, additional

Published
2015
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14. Hippocampus reidi, a Marine Natural Product Reduces TH2 Cytokine Levels and Attenuates NF-KB Expression.

Author

SrFerreira Silva, Hugo Bernardino, Silva, Raimon RIOS, Queiroz Carneiro, Norma Vilany, Pires, Anaque Oliveira, Serafim Machado, Marta Santos, Marques, Cíntia Rodrigues, Costa, Ryan Santos, Brasil, Tamires Carneiro, Pessoa ALBUQUERQUE Filho, Paulo, Franco, Eryvelton Souza, Souza Maia, Maria Bernadete, Silveira, Rosana Beatriz, Alcântara-Neves, Neuza Maria, and Figueiredo, Camila Alexandrina

Published
2017
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15. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.

Author

Cerqueira-Lima AT, Alcântara-Neves NM, de Carvalho LC, Costa RS, Barbosa-Filho JM, Piuvezam M, Momtchilo R, Barboza R, de Jesus Oliveira E, Marinho A, and Figueiredo CA

Subjects
Alkaloids isolation & purification, Animals, Asthma metabolism, Bronchoalveolar Lavage Fluid cytology, Bronchoalveolar Lavage Fluid immunology, Cytokines immunology, Cytokines metabolism, Eosinophil Peroxidase metabolism, Female, Immunoglobulin E immunology, Immunoglobulin E metabolism, Mice, Mice, Inbred A, Models, Theoretical, Plant Extracts pharmacology, Plant Leaves chemistry, Rats, Rats, Wistar, Alkaloids pharmacology, Asthma drug therapy, Asthma immunology, Cissampelos chemistry, Mites immunology
Abstract

Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatment.

Published
2010
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