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182 results on '"Cotterill, Rodney"'

8. Mammalian and avian neuroanatomy and the question of consciousness in birds

Author

Butler, Ann B. and Cotterill, Rodney M.J.

Subjects
Neuroanatomy -- Research, Birds -- Research, Consciousness in animals -- Research, Mammals -- Research, Biological sciences, Research
Abstract

Some birds display behavior reminiscent of the sophisticated cognition and higher levels of consciousness usually associated with mammals, including the ability to fashion tools and to learn vocal sequences. It is thus important to ask what neuroanatomical attributes these taxonomic classes have in common and whether there are nevertheless significant differences. While the underlying brain structures of birds and mammals are remarkably similar in many respects, including high brain-body ratios and many aspects of brain circuitry, the architectural arrangements of neurons, particularly in the pallium, show marked dissimilarity. The neural substrate for complex cognitive functions that are associated with higher-level consciousness in mammals and birds alike may thus be based on patterns of circuitry rather than on local architectural constraints. In contrast, the corresponding circuits in reptiles are substantially less elaborated, with some components actually lacking, and in amphibian brains, the major thalamopallial circuits involving sensory relay nuclei are conspicuously absent. On the basis of these criteria, the potential for higher-level consciousness in these taxa appears to be lower than in birds and mammals., Introduction Elucidating the mechanism or mechanisms by which sets of neurons generate consciousness requires that one be able to identify at least some of the animals, in addition to humans, [...]

Published
2006

14. Contributors

Author

Akaârir, M., primary, Århem, Peter, additional, Baars, Bernard J., additional, Butler, Ann B., additional, Changeux, Jean-Pierre, additional, Cotterill, Rodney M.J., additional, Esteban, S., additional, Freeman, Walter J., additional, Gamundi, A., additional, Gärdenfors, Peter, additional, Lagercrantz, Hugo, additional, Liljenström, Hans, additional, Lindahl, B.I.B., additional, Macphail, Euan, additional, Manger, Paul R., additional, Merker, Björn, additional, Munz, Peter, additional, Nicolau, M.C., additional, Rial, R.V., additional, and van Swinderen, Bruno, additional

Published
2007
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24. Physics of the brain

Author

Cotterill, Rodney M. J., Araki, H., editor, Ehlers, J., editor, Hepp, K., editor, Kippenhahn, R., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Baeriswyl, Dionys, editor, Droz, Michel, editor, Malaspinas, Andreas, editor, and Martinoli, Piero, editor

Published
1987
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26. Broken cups and atoms

Author

Cotterill, Rodney

Abstract

You can gather the pieces of a broken coffee cup and fit them together, but they won't stick. The fit may be good, but you can't make it good enough. […]

Published
1999

50. A 3.2 Mb deletion on 18q12 in a patient with childhood autism and high-grade myopia.

Author

Gilling, Mette, Lauritsen, Marlene Briciet, Møller, Morten, Henriksen, Karen Friis, Vicente, Astrid, Oliveira, Guiomar, Cintin, Christina, Eiberg, Hans, Andersen, Paal Skyt, Mors, Ole, Rosenberg, Thomas, Brøndum-Nielsen, Karen, Cotterill, Rodney M J, Lundsteen, Claes, Ropers, Hans-Hilger, Ullmann, Reinhard, Bache, Iben, Tümer, Zeynep, Tommerup, Niels, Gilling, Mette, Lauritsen, Marlene Briciet, Møller, Morten, Henriksen, Karen Friis, Vicente, Astrid, Oliveira, Guiomar, Cintin, Christina, Eiberg, Hans, Andersen, Paal Skyt, Mors, Ole, Rosenberg, Thomas, Brøndum-Nielsen, Karen, Cotterill, Rodney M J, Lundsteen, Claes, Ropers, Hans-Hilger, Ullmann, Reinhard, Bache, Iben, Tümer, Zeynep, and Tommerup, Niels

Abstract

Udgivelsesdato: 2008-Mar, Autism spectrum disorders (ASDs) are a heterogeneous group of disorders with unknown aetiology. Even though ASDs are suggested to be among the most heritable complex disorders, only a few reproducible mutations leading to susceptibility for ASD have been identified. In an attempt to identify ASD susceptibility genes through chromosome rearrangements, we investigated a female patient with childhood autism and high-grade myopia, and an apparently balanced de novo translocation, t(5;18)(q34;q12.2). Further analyses revealed a 3.2 Mb deletion encompassing 17 genes at the 18q break point and an additional deletion of 1.27 Mb containing two genes on chromosome 4q35. Q-PCR analysis of 14 of the 17 genes deleted on chromosome 18 showed that 11 of these genes were expressed in the brain, suggesting that haploinsufficiency of one or more genes may have contributed to the childhood autism phenotype of the patient. Identification of multiple genetic changes in this patient with childhood autism agrees with the most frequently suggested genetic model of ASDs as complex, polygenic disorders.

Published
2008

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