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The synchronous occurence of primary carcinomas of endometrium and ovary is well recognized. Malignant peripheral nerve sheath tumours (MPNSTs) may also rarely occur in patients diagnosed with malignancies of the female genital tract. We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal MPNST. Ascites cytology and endometrial biopsy, followed by hysterectomy and bilateral adnexectomy, were performed to remove the synchronous tumors. Histology was suggestive of synchronous endometrial endometrioid carcinoma and ovarian mucinous adenocarcinoma. After the removal of the retroperitoneal tumor, a MPNST was diagnosed by immunohistochemistry. The patient developed two consecutive vaginal tumors diagnosed as metastases of the previously diagnosed endometrial carcinoma. Although synchronous tumors of endometrium and ovary were relatively early staged and consequently had a favorable prognosis, subsequently occuring implants along the lower genital tract and the metachronous MPNST added up to a poor prognosis. [ABSTRACT FROM AUTHOR]

Unlabelled: Our main aim in this study was to investigate the number of neutrophils at the bronchial mucosae level in patients diagnosed with bronchial asthma., Material and Methods: We examined a number of 21 patients with different level of severity of asthma (according to GINA). Fragments of bronchial mucosae were obtained through fiberbronchoscopy, prepared for histological examination for performing the immune staining with anti-elastase antibodies., Results: We found significantly higher number of neutrophils at microscopic examination in the patients with severe asthma than in healthy subjects or mild asthma subjects (r = 0.79, p < 0.01)., Conclusion: The results of this study suggest that neutrophils can be considered a specific lesion in patients with severe bronchial asthma.