Search

Your search keyword '"Couec, Marie-Laure"' showing total 14 results
Start Over Author "Couec, Marie-Laure"
14 results on '"Couec, Marie-Laure"'

3. Added value of molecular karyotype in childhood acute lymphoblastic leukemia.

Author

Camuset, Margaux, Le Calvez, Baptiste, Theisen, Olivier, Godon, Catherine, Grain, Audrey, Thomas, Caroline, Couec, Marie‐Laure, Béné, Marie C., Rialland, Fanny, and Eveillard, Marion

Subjects
LYMPHOBLASTIC leukemia, ACUTE leukemia, KARYOTYPES, NUCLEOTIDE sequencing, SINGLE nucleotide polymorphisms
Abstract

Background: Thanks to an improved therapeutic regimen in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), 5 year‐overall survival now exceeds 90%. Unfortunately, the 25% of children who relapse have an initial poor prognosis, potentially driven by pre‐existing or emerging molecular anomalies. The latter are initially and essentially identified by cytogenetics. However, some subtle alterations are not visible through karyotyping. Methods: Single nucleotide polymorphisms (SNP) array is an alternative way of chromosomal analysis allowing for a more in‐depth evaluation of chromosomal modifications such as the assessment of copy number alterations (CNA) and loss of heterozygosity (LOH). This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP‐ALL and in a prospective cohort of 38 newly diagnosed childhood cases. Results: In the matched study, compared to the initial karyotype, SNP array analysis reclassified two patients as poor prognosis cases. Modulation during relapse was seen for 4 CNA and 0.9 LOH. In the prospective study, SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor prognosis. Ultimately, in all the children tested, SNP array allowed to identify additional anomalies compared to conventional karyotype, refine its prognostic value and identify some druggable anomalies that could be used for precision medicine. Overall, the anomalies detected could be segregated in four groups respectively involved in B‐cell development, cell proliferation, transcription and molecular pathways. Conclusion: SNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL, especially for patients initially classified as intermediate prognosis. This complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

4. System-level immune monitoring reveals new pathophysiological features in hepatitis-associated aplastic anemia

Author

Braudeau, Cecile, primary, Delbos, Laurence, additional, Couec, Marie-Laure, additional, Danic, Gwenvael, additional, Chevreuil, Justine, additional, Lecuroux, Camille, additional, Grain, Audrey, additional, Eveillard, Marion, additional, Rialland, Fanny, additional, Sicre de Fontbrune, Flore, additional, Beriou, Gaelle, additional, Degauque, Nicolas, additional, Michonneau, David, additional, Josien, Regis, additional, de Latour, Régis Peffault, additional, Thomas, Caroline, additional, and Martin, Jerome C., additional

Published
2023
Full Text
View/download PDF

5. Rituximab in addition to LMB-based chemotherapy regimen in children and adolescents with primary mediastinal large B-cell lymphoma: results of the French LMB2001 prospective study

Author

Dourthe, Marie Emilie, primary, Phulpin, Aurélie, additional, Auperin, Anne, additional, Bosq, Jacques, additional, Couec, Marie-Laure, additional, Dartigues, Peggy, additional, Ducassou, Stéphane, additional, Garnier, Nathalie, additional, Haouy, Stéphanie, additional, Leblanc, Thierry, additional, Leruste, Amaury, additional, Paillard, Catherine, additional, Rigaud, Charlotte, additional, Simonin, Mathieu, additional, Patte, Catherine, additional, and Minard-Colin, Véronique, additional

Published
2022
Full Text
View/download PDF

6. Descriptive analysis of sickle cell patients living in France

Author

Gerardin, Marie, Rousselet, Morgane, Couec, Marie-Laure, Masseau, Agathe, Guerlais, Marylène, Authier, Nicolas, Deheul, Sylvie, Roussin, Anne, Micallef, Joelle, Djezzar, Samira, Feuillet, Fanny, Jolliet, Pascale, Victorri-Vigneau, Caroline, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques

Subjects
MESH: Adolescent, MESH: Aged, MESH: Humans, MESH: Middle Aged, MESH: Analgesics, MESH: Psychotropic Drugs, [SDV]Life Sciences [q-bio], MESH: Child, Preschool, MESH: Quality of Life, MESH: Adult, MESH: Pain Measurement, MESH: Male, MESH: France, MESH: Cross-Sectional Studies, MESH: Drug Prescriptions, MESH: Young Adult, MESH: Severity of Illness Index, MESH: Child, MESH: Pain, MESH: Anemia, Sickle Cell, MESH: Female, MESH: Pain Management, MESH: Treatment Outcome
Abstract

International audience; Background Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of the PHEDRE study (Pharmacodépendance Et DREpanocytose—drug dependence and sickle-cell disease), which is the largest study of patients with SCD in France. This paper intends to describe characteristics of the French SCD population. We also aimed to assess the impact of the disease on the lives of patients using objective and subjective variables. Methods The PHEDRE study was a national multicentric observational study. Adults, adolescents and children with a confirmed SCD diagnosis were included in the study by their referring doctor. Then, they were interviewed by phone about their socioeconomic status, about the impact of the disease on their lives and about their analgesic and psychoactive drug use. Results The study population consisted of 872 patients (28% were minors). Seventy-two percent of adults were active, and all minors were in school. Many patients presented criteria of severe SCD. Seventy-five percent were homozygous SS, 15% were double heterozygotes SC and 8% were heterozygotes Sβthal, 87% received specific treatment, 58% were hospitalized at least once for vaso-occlusive crisis in the past 12 months, and the number of analgesic drugs taken averaged 3.8. Seventy-five percent of patients reported academic or professional consequences related to their SCD, and 52% reported social consequences. Conclusions The impact of SCD on patients’ lives can be significant, nevertheless their social integration seems to be maintained. We highlighted respect of recommendations regarding analgesic treatments and only a few patients used tobacco, alcohol or cannabis. Trial registration Clinical Trials, NCT02580565 ; https://clinicaltrials.gov/ Registered 16 October 2015.

Published
2021

7. Should treatment of ALK-positive anaplastic large cell lymphoma be stratified according to minimal residual disease?

Author

Rigaud, Charlotte, Abbas, Rachid, Grand, David, Minard‐Colin, Véronique, Aladjidi, Nathalie, Buchbinder, Nimrod, Garnier, Nathalie, Plat, Geneviève, Couec, Marie‐Laure, Duplan, Mylène, Lambilliotte, Anne, Schmitt, Claudine, Leblanc, Thierry, Lamant, Laurence, Brugières, Laurence, Minard-Colin, Véronique, and Couec, Marie-Laure

Published
2021
Full Text
View/download PDF

9. Outcome of relapse in children and adolescents with B‐cell non‐Hodgkin lymphoma and mature acute leukemia: A report from the French LMB study

Author

Rigaud, Charlotte, primary, Auperin, Anne, additional, Jourdain, Anne, additional, Haouy, Stephanie, additional, Couec, Marie‐Laure, additional, Aladjidi, Nathalie, additional, Gandemer, Virginie, additional, Lambliotte, Anne, additional, Plat, Geneviève, additional, Landman‐Parker, Judith, additional, Michon, Jean, additional, Leblanc, Thierry, additional, Patte, Catherine, additional, and Minard‐Colin, Veronique, additional

Published
2019
Full Text
View/download PDF

10. Évaluation de la prévalence des consommations problématiques de Meopa et d’antalgiques dans la population drépanocytaire française : l’étude Phedre (pharmacodépendance et drépanocytose)

Author

Gérardin, Marie, primary, Couec, Marie-Laure, additional, Grall-Bronnec, Marie, additional, Rousselet, Morgane, additional, Bonnot, Olivier, additional, Drouineau, Marie-Hélène, additional, Jolliet, Pascale, additional, and Victorri-Vigneau, Caroline, additional

Published
2017
Full Text
View/download PDF

12. PHEDRE trial protocol – observational study of the prevalence of problematic use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and analgesics in the French sickle-cell disease population

Author

Gérardin, Marie, primary, Couec, Marie-Laure, additional, Grall-Bronnec, Marie, additional, Feuillet, Fanny, additional, Wainstein, Laura, additional, Rousselet, Morgane, additional, Pinot, Marie-Lyne, additional, Perrouin, Fanny, additional, Bonnot, Olivier, additional, Drouineau, Marie-Hélène, additional, Jolliet, Pascale, additional, and Victorri-Vigneau, Caroline, additional

Published
2015
Full Text
View/download PDF

14. Excellent outcome of children/adolescents with primary mediastinal large B-cell lymphoma treated with FAB/LMB-based chemotherapy regimen with rituximab.

Author

Dourthe ME, Auperin A, Rigaud C, Barbati M, Bonneau J, Buchbinder N, Couec ML, Dartigues P, Ducassou S, Garnier N, Haouy S, Jonca B, Jourdain A, Leruste A, Molina T, Montravers F, Pasquet M, Phulpin A, Poirée M, Simonin M, Spiegel A, Verschuur A, Leblanc T, Landman-Parker J, Patte C, and Minard-Colin V

Abstract

Not available.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results