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37 results on '"Coulombe-Huntington J"'

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2. Comparison of Affymetrix Gene Array with the Exon Array shows potential application for detection of transcript isoform variation

3. The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.

4. Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition.

5. Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations.

6. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

7. The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.

8. Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.

9. Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.

10. Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

11. A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.

12. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

13. PRMT5 inhibition disrupts splicing and stemness in glioblastoma.

14. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

15. The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.

16. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

17. Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.

18. Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.

19. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.

20. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

21. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

22. The BioGRID interaction database: 2019 update.

23. Interactome evolution: insights from genome-wide analyses of protein-protein interactions.

24. A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome.

25. Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.

26. CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization.

27. Network Centrality Analysis in Fungi Reveals Complex Regulation of Lost and Gained Genes.

28. RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins.

29. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

30. Widespread macromolecular interaction perturbations in human genetic disorders.

31. A proteome-scale map of the human interactome network.

32. The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis.

33. Regulatory network structure as a dominant determinant of transcription factor evolutionary rate.

34. Fine-scale variation and genetic determinants of alternative splicing across individuals.

35. Comparison of Affymetrix Gene Array with the Exon Array shows potential application for detection of transcript isoform variation.

36. Intron loss and gain in Drosophila.

37. Characterization of intron loss events in mammals.

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