262 results on '"Coumar, Mohane Selvaraj"'
Search Results
2. Targeting survivin for cancer therapy: Strategies, small molecule inhibitors and vaccine based therapeutics in development
3. Microbiome analysis of Litopenaeus vannamei reveals Vibrio as main risk factor of white faeces syndrome
4. A transcription-independent role for HIF-1α in modulating microprocessor assembly.
5. Deciphering Breast Cancer Metastasis Cascade: A Systems Biology Approach Integrating Transcriptome and Interactome Insights for Target Discovery
6. Survivin - caspase protein-protein interaction: Experimental evidence and computational investigations to decipher the hotspot residues for drug targeting
7. Deciphering molecular mechanisms of metastasis: novel insights into targets and therapeutics
8. Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia
9. Multi-objective biofilm algorithm (MOBifi) for de novo drug design with special focus to anti-diabetic drugs
10. Lead identification and optimization
11. List of Contributors
12. Introduction of structural bioinformatics with respect to drug discovery
13. Docking-Based Virtual Screening Using PyRx Tool: Autophagy Target Vps34 as a Case Study
14. Contributors
15. Resources for Docking-Based Virtual Screening
16. Brief introduction of clinical research and trials
17. Retrieval of compounds
18. Target identification and validation
19. Exploring imidazo[4,5- g ]quinoline-4,9-dione derivatives as Acinetobacter baumannii efflux pump inhibitor: an in silico approach
20. In Silico Investigations of Chemical Constituents of Clerodendrum colebrookianum in the Anti-Hypertensive Drug Targets: ROCK, ACE, and PDE5
21. Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach
22. Design of novel ROCK inhibitors using fragment-based de novo drug design approach
23. Contributors
24. An Overview of Computational Methods, Tools, Servers, and Databases for Drug Repurposing
25. Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer
26. Synthesis, antitubercular evaluation, and molecular docking studies of hybrid pyridinium salts derived from isoniazid
27. Identification of a novel leukemic-specific splice variant of DNMT3B and its stability
28. Ensemble-based virtual screening: identification of a potential allosteric inhibitor of Bcr-Abl
29. Pan-cancer gene expression analysis: Identification of deregulated autophagy genes and drugs to target them
30. Ligand efficiency based approach for efficient virtual screening of compound libraries
31. Protein-Protein Interactions (PPIs) as an Alternative to Targeting the ATP Binding Site of Kinase
32. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
33. Identification of natural inhibitors of Bcr‐Abl for the treatment of chronic myeloid leukemia
34. Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity
35. Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting
36. Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways
37. Protein-Protein Interactions (PPIs) as an Alternative to Targeting the ATP Binding Site of Kinase
38. Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting
39. Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase
40. Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting.
41. The ribosomal protein eL21 interacts with the protein lysine methyltransferase SMYD2 and regulates its steady state levels
42. Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design
43. Development of a Robust Scale-Up Synthetic Route for BPR1K871: A Clinical Candidate for the Treatment of Acute Myeloid Leukemia and Solid Tumors
44. Chapter 25 - An Overview of Computational Methods, Tools, Servers, and Databases for Drug Repurposing
45. The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells
46. Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors
47. Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors
48. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening
49. BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
50. Design of a potent anticancer lead inspired by natural products from traditional Indian medicine
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