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4. High‐Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single‐Nuclei RNA Sequencing.

Author

Laitman, Benjamin M., Charytonowicz, Daniel, Zhu, Ashley J., Lynch, Katie, Varelas, Eleni A., Burton, Madeline, Andreou, Christina, Kore, Pragati, Kirke, Diana N., Chen, Ya‐Wen, Beaumont, Kristin G., Sebra, Robert, Genden, Eric M., and Courey, Mark S.

Abstract

Introduction: The function of the vocal folds (VFs) is determined by the phenotype, abundance, and distribution of differentiated cells within specific microenvironments. Identifying this histologic framework is crucial in understanding laryngeal disease. A paucity of studies investigating VF cellular heterogeneity has been undertaken. Here, we examined the cellular landscape of human VFs by utilizing single‐nuclei RNA‐sequencing. Methods: Normal true VF tissue was excised from five patients undergoing pitch elevation surgery. Tissue was snap frozen in liquid nitrogen and subjected to cellular digestion and nuclear extraction. Nuclei were processed for single‐nucleus sequencing using the 10X Genomics Chromium platform. Sequencing reads were assembled using cellranger and analyzed with the scanpy package in python. Results: RNA sequencing revealed 18 global cell clusters. While many were of epithelial origin, expected cell types, such as fibroblasts, immune cells, muscle cells, and endothelial cells were present. Subcluster analysis defined unique epithelial, immune, and fibroblast subpopulations. Conclusion: This study evaluated the cellular heterogeneity of normal human VFs by utilizing single‐nuclei RNA‐sequencing. With further confirmation through additional spatial sequencing and microscopic imaging, a novel cellular map of the VFs may provide insight into new cellular targets for VF disease. Level of Evidence: NA Laryngoscope, 134:3193–3200, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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10. The diagnostic role of high-speed vocal fold vibratory imaging.

Author

Mendelsohn, Abie H, Remacle, Marc, Courey, Mark S, Gerhard, Friedrich, and Postma, Gregory N

Subjects
Vocal Cords, Humans, Stroboscopy, Retrospective Studies, Videotape Recording, Adolescent, Adult, Aged, Middle Aged, Female, Male, Dysphonia, Young Adult, Diagnosis, High speed, Interrater reliability, Laryngeal examination, Laryngoscopy, Visual subjective evaluation, Vocal fold vibration, Voice diagnostics, Bioengineering, Clinical Research, Clinical Trials and Supportive Activities, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Clinical Sciences, Performing Arts and Creative Writing, Speech-Language Pathology & Audiology
Abstract

ObjectiveAlthough high-speed imaging (HSI) has been identified as a valuable tool in phonatory biomechanics research, to date, there have only been a selected number of reports investigating the clinical utility of HSI. We aim to elucidate the role of HSI in the diagnosis of the dysphonic patient.MethodsThe video files from 28 consecutive dysphonic patients with concurrently acquired videostroboscopy and HSI were retrospectively collected. Stroboscopy video files were edited to include vibratory motion only. Videos were then anonymously and randomly presented to four academic laryngologists. Experts were asked to assign a single best diagnosis for each video file. Assigned diagnoses were then compared with treatment diagnoses conferred based on medical history, phonatory evaluation, laryngeal examination, and response to treatment.ResultsInterrater analysis for the four laryngologists demonstrated significant and meaningful correlations for the diagnoses of polyps, cysts, nodules, and normal examination using stroboscopy (kappa > 0.40, P < 0.001). The experts demonstrated significant and meaningful correlations for the diagnoses of polyps, presbyphonia, and normal examination using HSI (kappa > 0.40, P < 0.001). Combined intrarater analysis performed by comparing single rater's diagnosis for single patient across both modalities resulted in poor correlation without statistical significance (kappa = 0.30, P = 0.07). Both stroboscopy- and HSI-assigned diagnoses matched the treatment diagnoses at equal predicted frequencies (32.3%), as demonstrated through multivariate logistic regression analysis (P < 0.001).ConclusionOverall, HSI did not improve the diagnostic accuracy above stroboscopy alone. Although specific laryngeal states such as presbyphonia may be better diagnosed with HSI, further studies are required to define HSI's precise role in the clinical setting.

Published
2013

12. Positive Predictive Value of Endoscopic Findings to Diagnose Vocal Fold Paresis.

Author

Rapoport, Sarah K., Basharat, Usmaan, Kirke, Diana N., and Courey, Mark S.

Abstract

Objective: Laryngoscopy corresponding with laryngeal electromyography (LEMG) is essential in diagnosing vocal fold paresis. However, baseline asymmetry or other diseases oftentimes confound the exam, making diagnosis difficult. There is currently no agreed upon endoscopic criteria proven to reliably correlate with LEMG findings. We define a set of endoscopic findings termed "paresis triad" that, when present together, reliably correlate with LEMG. The paresis triad consists of (1) hypocontraction of the weak side of the larynx with increased ventricular show, (2) hypercontraction of the intact side with bulging of the false fold covering the ventricle, and (3) tilting of the interarytenoid cleft to the weak side. Methods: We performed a retrospective review of patients with laryngeal asymmetry on laryngoscopy. Patients were divided into two groups: those with consistent paresis triad findings across all pitches and intensities, and those without. All patients underwent LEMG by a neurolaryngologist blinded to the laryngoscopic findings. The endoscopies were then rereviewed in a blinded manner by a second laryngologist to assess inter‐ and intrarater reliability for identification of the triad. Results: Twelve patients met inclusion criteria (age 50 +/−15, 7F:5M). Nine had the paresis triad. Three had an inconsistent triad. All patients with the paresis triad had LEMG findings consistent with neurologic injury on the suspected side. All patients with inconsistent triad findings had normal LEMG. Conclusions: Our findings suggest the proposed laryngoscopic paresis triad may be useful objective criteria to diagnose paresis without the need for LEMG. Further prospective studies should examine a larger series of patients. Level of Evidence: 4 Laryngoscope, 133:1712–1716, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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18. 1‐Year Results of Combined Modified Wendler Glottoplasty with Voice Therapy in Transgender Women.

Author

Rapoport, Sarah K., Park, Christopher, Varelas, Eleni A, Chang, Joseph, Brown, Sarah K., Kinberg, Eliezer, Goldberg, Leanne, and Courey, Mark S.

Abstract

Background: To date, 1‐year evaluation of pitch elevation in patients undergoing modified Wendler glottoplasty (WG) in combination with VT has not been assessed. Objectives: To determine whether 1‐year pitch elevation is sustained in patients who undergo modified WG in combination with VT for voice feminization. Methods: A retrospective review of patients who underwent WG in combination with voice therapy (VT) was performed from 2016 to 2020. Charts were reviewed for sustained vowel fundamental frequency (F0/a/), speaking fundamental frequency (SF0), and Trans Woman Voice Questionnaire (TWVQ) at preoperative, initial postoperative (3–6 months after surgery), and 12‐month postoperative visits. Results: Change in average F0/a/, SF0 and TWVQ was 50.25 Hz, 32.96 Hz, and 32.6 at 12‐months postoperatively compared to preoperative values. Initial and 12‐month postoperative SF0 were significantly higher than preoperative SF0 (Mann–Whitney U test p = 0.0042, p = 0.0010). There was no difference in initial postoperative and 12‐month postoperative SF0 (p = 0.50). TWVQ at 12 months was significantly lower than preoperative TWVQ (ANOVA p < 0.001, Tukey honestly significant difference HSD p < 0.05). Conclusions: Pitch elevation remains sustained at one year in patients undergoing modified WG in combination with VT. Modified Wendler glottoplasty combined with VT results in relatively long‐term improvements in voice‐related quality of life and is possibly a beneficial addition in the long‐term management of patients who desire voice feminization. Level of Evidence: 4 Laryngoscope, 133:615–620, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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19. Contributors

Author

Adams, Lewis, primary, Adler, Dan Elie, additional, Agusti, Alvar, additional, Akoumianaki, Evangelia, additional, Alberg, Anthony J., additional, Albertine, Kurt H., additional, Alexander, Barbara D., additional, Alfille, Paul H., additional, Anantham, Devanand, additional, Arenberg, Douglas A., additional, Ayas, Najib T., additional, Bagchi, Aranya, additional, Balmes, John Randolph, additional, Banaei, Niaz, additional, Barnett, Christopher F., additional, Baughman, Robert P., additional, Becklake, Margaret R., additional, Benditt, Joshua O., additional, Benowitz, Neal L., additional, Bhakta, Nirav R., additional, Bhave, Anant D., additional, Blanc, Paul D., additional, Bleecker, Eugene R., additional, Bove, Alfred A., additional, Bradley, T. Douglas, additional, Brambilla, Elisabeth, additional, Broaddus, V. Courtney, additional, Brochard, Laurent, additional, Brock, Malcolm V., additional, Brown, Kevin K., additional, Brunetta, Paul G., additional, Cadranel, Jacques, additional, Celli, Bartolome, additional, Chan, Edward D., additional, Channick, Richard N., additional, Chastre, Jean, additional, Cheng, Guang-Shing, additional, Chin, Kelly, additional, Chung, Kian Fan, additional, Clerici, Christine, additional, Colby, Thomas V., additional, Collard, Harold R., additional, Cool, Carlyne D., additional, Cordier, Jean-François, additional, Cordioli, Ricardo Luiz, additional, Corte, Tamera J., additional, Cottin, Vincent, additional, Courey, Mark S., additional, Cowie, Robert L., additional, Crothers, Kristina, additional, Curley, Gerard F., additional, Daley, Charles L., additional, Davis, J. Lucian, additional, De Marco, Teresa, additional, Deresinski, Stanley C., additional, Deroose, Christophe, additional, Dobbs, Leland G., additional, Dooms, Christophe, additional, Downey, Gregory P., additional, du Bois, Roland M., additional, Dulohery, Megan M., additional, Effros, Richard M., additional, Eisner, Mark D., additional, Elicker, Brett M., additional, Ernst, Armin, additional, Ernst, Joel D., additional, Fahy, John V., additional, Fedullo, Peter F., additional, Feller-Kopman, David, additional, Fenster, Brett E., additional, Fingerlin, Tasha E., additional, Fontenot, Andrew P., additional, Frankel, Stephen K., additional, Garcia, Joe G.N., additional, Gebhart, G.F., additional, Gilstrap, Daniel Lee, additional, Girard, Nicolas, additional, Gladwin, Mark T., additional, Glenny, Robb W., additional, Gold, Warren M., additional, Gotway, Michael B., additional, Grasselli, Giacomo, additional, Greenberg, James M., additional, Griffith, David E., additional, Gruden, James F., additional, Han, MeiLan King, additional, Henderson, William, additional, Hill, Nicholas S., additional, Hoover, Wynton, additional, Hopewell, Philip C., additional, Horan-Saullo, Jennifer L., additional, Horner, Richard L., additional, Huang, Laurence, additional, Huchon, Gérard, additional, Inoue, Yoshikazu, additional, Iseman, Michael D., additional, Jackson, James E., additional, Jakubzick, Claudia V., additional, Janssen, Julius P., additional, Jett, James R., additional, Jones, Kirk, additional, Judson, Marc A., additional, Kato-Maeda, Midori, additional, Kavanagh, Brian P., additional, Keshavjee, Shaf, additional, Kim, Kami, additional, Kimoff, R. John, additional, King, Talmadge E., additional, Klein, Jeffrey S., additional, Koth, Laura L., additional, Kotloff, Robert M., additional, Kraft, Monica, additional, Küpeli, Elif, additional, Laffey, John G., additional, Lapinsky, Stephen E., additional, Lazarus, Stephen C., additional, Lee, Frances Eun-Hyung, additional, Lee, Jarone, additional, Lee, Y.C. Gary, additional, Lee, Warren L., additional, Lee-Chiong, Teofilo L., additional, Lemière, Catherine, additional, Light, Richard W., additional, Limper, Andrew H., additional, Loddenkemper, Robert, additional, Lugogo, Njira, additional, Luisetti, Maurizio, additional, Luks, Andrew M., additional, Luyt, Charles-Edouard, additional, Machado, Roberto F., additional, MacIntyre, Neil R., additional, MacNee, William, additional, Madtes, David K., additional, Maier, Lisa A., additional, Maldonado, Fabien, additional, Malhotra, Atul, additional, Martin, Thomas R., additional, Maskell, Nick A., additional, Mason, Robert J., additional, Massion, Pierre P., additional, Matthay, Michael A., additional, Matthay, Richard A., additional, Mayer, Annyce S., additional, Mazzone, Stuart B., additional, McCool, F. Dennis, additional, McCormack, Francis Xavier, additional, Mehta, Atul C., additional, Menéndez, Rosario, additional, Morgenthau, Adam S., additional, Morris, Alison, additional, Morris, Timothy A., additional, Muncey, Aaron R., additional, Murray, John F., additional, Myers, Jeffrey L., additional, Nadel, Jay A., additional, Nelson-Piercy, Catherine, additional, Neuman, Tom S., additional, Nosanchuk, Joshua D., additional, O'Riordan, Thomas G., additional, Ortega, Victor Enrique, additional, Panse, Prasad M., additional, Pao, William, additional, Paré, Peter A., additional, Park, David R., additional, Pastis, Nicholas J., additional, Patroniti, Nicolò, additional, Patterson, Karen C., additional, Pesenti, Antonio, additional, Pickens, Allan, additional, Pinsky, Benjamin A., additional, Pletcher, Steven D., additional, Powell, Frank L., additional, Que, Loretta G., additional, Redente, Elizabeth F., additional, Riches, David W.H., additional, Robinson, Bruce W.S., additional, Rodriguez-Roisin, Roberto, additional, Rose, Cecile S., additional, Routes, John M., additional, Rowe, Steven M., additional, Ryan, Clodagh M., additional, Ryu, Jay H., additional, Samet, Jonathan M., additional, Sandrock, Christian E., additional, Schoene, Robert B., additional, Schwartz, David A., additional, Schwartzstein, Richard M., additional, Schwarz, Marvin I., additional, Selman, Moisés, additional, Sequist, Lecia V., additional, Shannon, John M., additional, Shovlin, Claire L., additional, Silvestri, Gerard A., additional, Simonian, Philip L., additional, Singer, Jonathan P., additional, Slutsky, Arthur S., additional, Smaldone, Gerald C., additional, Solomon, George M., additional, Sorscher, Eric J., additional, Swenson, Erik R., additional, Tanner, Nichole T., additional, Tanowitz, Herbert B., additional, Torres, Antoni, additional, Trapnell, Bruce C., additional, Travis, William David, additional, Treanor, John J., additional, Tzelepis, George E., additional, Vandenplas, Olivier, additional, Vansteenkiste, Johan F., additional, Varghese, Thomas K., additional, Vestbo, Jørgen, additional, Wagner, Peter D., additional, Wahidi, Momen M., additional, Wallace, W. Dean, additional, Weiss, Louis M., additional, Weiss, Scott T., additional, Wells, Athol U., additional, West, John B., additional, White, Douglas B., additional, Wiener-Kronish, Jeanine P., additional, Wikenheiser-Brokamp, Kathryn A., additional, Woodruff, Prescott G., additional, Wunderink, Richard G., additional, Yeh, D. Dante, additional, Zemans, Rachel L., additional, Zimmerman, Leslie, additional, and Zuwallack, Richard L., additional

Published
2016
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25. Transoral Laser Resection of Glottic Tumors

Author

Christopoulos, Apostolos, primary, Holsinger, F. Christopher, additional, Ferris, Robert L., additional, Bernal-Sprekelsen, Manuel, additional, Vilaseca, Isabel, additional, Courey, Mark S., additional, Moore, Eric J., additional, Peretti, Giorgio, additional, and Piazza, Cesare, additional

Published
2011
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26. Reviewers

Author

Andersen, Peter E., primary, Armstrong, William B., additional, Assael, Leon A., additional, Bayles, Stephen W., additional, Belafsky, Peter C., additional, Bernal-Sprekelsen, Manuel, additional, Bhatti, Nasir I., additional, Burkey, Brian B., additional, Campbell, Bruce H., additional, Carroll, William R., additional, Caruana, Salvatore M., additional, Cernea, Claudio R., additional, Civantos, Francisco J., additional, Clayman, Gary L., additional, Cohen, James I., additional, Cohen, Seth M., additional, Cook, Ted A., additional, Cotton, Robin T., additional, Courey, Mark S., additional, Davidson, Bruce J., additional, Day, Terry A., additional, Deschler, Daniel G., additional, Dionigi, Gianlorenzo, additional, Donald, Paul James, additional, Eisele, David W., additional, Farwell, D. Gregory, additional, Fedok, Fred G., additional, Ferris, Robert L., additional, Flint, Paul W., additional, Freeman, Jeremy L., additional, Friedlander, Paul L., additional, Futran, Neal, additional, Gapany, Markus, additional, Garrett, C. Gaelyn, additional, Genden, Eric M., additional, Goepfert, Helmuth, additional, Goldberg, Andrew N., additional, Gross, Neil D., additional, Gullane, Patrick J., additional, Har-El, Gady, additional, Hessel, Amy C., additional, Hilger, Peter A., additional, Hilgers, Frans J.M., additional, Hoffman, Henry T., additional, Holsinger, F. Christopher, additional, Hom, David B., additional, Howard, David, additional, Irish, Jonathan, additional, Johnson, Jonas T., additional, Kaiser, Larry R., additional, Kandil, Emad, additional, Kraus, Dennis, additional, Kuppersmith, Ronald B., additional, Laccourreye, Ollivier, additional, Lambright, Eric S., additional, Lee, Jeffrey E., additional, Leonetti, John P., additional, Lombardi, Celestino Pio, additional, Lydiatt, William M., additional, Magnuson, Jeffery Scott, additional, Maisel, Robert H., additional, Marchese-Ragona, Rosario, additional, Martindale, Robert G., additional, Marzo, Sam J., additional, McCulloch, Timothy M., additional, McWhorter, Andrew J., additional, Medina, Jesus E., additional, Méndez, Eduardo, additional, Merati, Albert L., additional, Meyer, Tanya K., additional, Miccoli, Paolo, additional, Milczuk, Henry A., additional, Militsakh, Oleg, additional, Moore, Eric J., additional, Nakayama, Meijin, additional, Nuss, Roger C., additional, Olsen, Kerry D., additional, Olsen, Steven M., additional, Orloff, Lisa A., additional, Ossoff, Robert H., additional, Peretti, Giorgio, additional, Perrier, Nancy D., additional, Piazza, Cesare, additional, Putnam, Joe B., additional, Randolph, Gregory W., additional, Remacle, Marc, additional, Richards, Alan T., additional, Richtsmeier, William J., additional, Ridge, John A., additional, Rosen, Clark A., additional, Rosenthal, Eben L., additional, Saunders, John R., additional, Schindler, Joshua S., additional, Schuller, David E., additional, Sewnaik, Aniel, additional, Shaha, Ashok R., additional, Shindo, Maisie, additional, Shockley, William W., additional, Sidman, James, additional, Simpson, C. Blake, additional, Sinclair, Catherine F., additional, Smith, James D., additional, Smith, Timothy L., additional, Snyderman, Carl Henry, additional, Sofferman, Robert A., additional, Spiro, Jeffrey D., additional, Steiner, Wolfgang, additional, Terris, David J., additional, Tufano, Ralph P., additional, Valentino, Joseph, additional, Vilaseca, Isabel, additional, Wang, Stephen J., additional, Wax, Mark K., additional, Weber, Randal S., additional, Wong, Richard J., additional, and Zeitels, Steven M., additional

Published
2011
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27. Contributors

Author

Abuzeid, Waleed M., primary, Adams, Meredith E., additional, Adamson, Peter A., additional, Adenis, Antoine, additional, Akst, Seth, additional, Albers, Sheri L., additional, Albert, David, additional, Alexander, Ronda E., additional, Archbold, Sue, additional, Armstrong, William B., additional, Arriaga, Moisés A., additional, Arts, H. Alexander, additional, Ashram, Yasmine A., additional, Aviv, Jonathan E., additional, Aygun, Nafi, additional, Backous, Douglas D., additional, Baker, Shan R., additional, Balkany, Thomas J., additional, Baloh, Robert W., additional, Barkmeier-Kraemer, Julie, additional, Baroody, Fuad M., additional, Bartlett, Nancy L., additional, Baskin, Jonathan Z., additional, Bastian, Robert W., additional, Bauer, Carol A., additional, Benninger, Michael S., additional, Bhama, Prabhat K., additional, Bhatti, Nasir Islam, additional, Blitzer, Andrew, additional, Boardman, Simone, additional, Boss, Emily F., additional, Brackmann, Derald E., additional, Bradford, Carol R., additional, Branstetter, Barton F., additional, Braun, Edward B., additional, Briggs, Robert J.S., additional, Brodie, Hilary A., additional, Brown, Carolyn J., additional, Brown, David J., additional, Brown, Kevin D., additional, Browne, J. Dale, additional, Buatti, John M., additional, Buchmann, Luke, additional, Byrne, Patrick J., additional, Galzada, Gabriel G., additional, Carey, John P., additional, Casselbrant, Margaretha L., additional, Castelnuovo, Paolo, additional, Chang, Steven, additional, Chegar, Burke E., additional, Chen, Amy, additional, Chen, Eunice Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheuk, Alice, additional, Chheda, Neil N., additional, Chien, Wade, additional, Choi, Sukgi S., additional, Chole, Richard A., additional, Christian, James M., additional, Chu, Eugene A., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Collins, Savita, additional, Collop, Nancy A., additional, Contencin, Philippe, additional, Cook, Raymond, additional, Corey, Jacquelynne, additional, Cotton, Robin T., additional, Couch, Marion Everett, additional, Courey, Mark S., additional, Crane, Benjamin T., additional, Crumley, Roger L., additional, Cruz, Oswaldo Laércio M., additional, Culicchia, Frank, additional, Cummings, Charles W., additional, Cunningham, Calhoun D., additional, Davis, Greg E., additional, Davis, Larry E., additional, Day, Terry A., additional, De la Cruz, Antonio, additional, Santina, Charles C. Della, additional, Denlinger, Chadrick, additional, Derkay, Craig S., additional, Diaz, Rodney C., additional, Dobie, Robert A., additional, Galli, Suzanne K. Doud, additional, Duncan, Newton O., additional, Eggers, Scott D.Z., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, El-Kashlan, Hussam K., additional, Elluru, Ravindhra G., additional, Ende, Kevin H., additional, Erman, Audrey B., additional, Fakhri, Samer, additional, Fakhry, Carole, additional, Farrior, Edward H., additional, Farrior, Richard T., additional, Faust, Russell A., additional, Ferguson, Berrylin J., additional, Flint, Paul W., additional, Francis, Howard W., additional, Fried, Marvin P., additional, Friedland, David R., additional, Friedman, Oren, additional, Frodel, John L., additional, Funk, Gerry F., additional, Gantz, Bruce J., additional, Garrett, C. Gaelyn, additional, Gartner-Schmidt, Jackie, additional, Gay, William Donald, additional, Ge, Norman N., additional, Gillespie, M. Boyd, additional, Girod, Douglas A., additional, Goding, George S., additional, Goldberg, Andrew N., additional, Goldenberg, David, additional, Graney, Daniel O., additional, Grant, Nazaneen N., additional, Grégoire, Vincent, additional, Gries, Heike, additional, Gubbels, Samuel P., additional, Guss, Joel, additional, Ha, Patrick, additional, Hamilton, Grant S., additional, Hanna, Ehab Y., additional, Harker, Lee A., additional, Harréus, Uli, additional, Harrison, Robert V., additional, Haughey, Bruce H., additional, Hellstein, John W., additional, Herzer, Kurt, additional, Hildebrand, Michael S., additional, Hilgers, Frans J.M., additional, Hill, Justin D., additional, Hinni, Michael L., additional, Hoffman, Henry T., additional, Holbrook, Eric H., additional, Holinger, Lauren D., additional, Holzapfel, Allison MacGregor, additional, Hom, David B., additional, House, John W., additional, House, Joyce Colton, additional, Hullar, Timothy E., additional, Husein, Murad, additional, Ing, Steven, additional, Iseli, Tim A., additional, Ishman, Stacey, additional, Jackler, Robert K., additional, Jameson, Brian, additional, Jenkins, Herman A., additional, Jin, Hong-Ryol, additional, Joe, John K., additional, Joe, Stephanie A., additional, Johnson, Gary, additional, Johnson, Rhonda, additional, Johnson, Tiffany A., additional, Johnson, Timothy M., additional, Jones, Nick S., additional, Kabaker, Sheldon S., additional, Karnell, Lucy H., additional, Kashima, Matthew L., additional, Kellman, Robert M., additional, Kelly, Paul E., additional, Kennedy, David W., additional, Khalid, Ayesha N., additional, Kies, Merrill S., additional, Kileny, Paul R., additional, Kim, David W., additional, Kim, Jason H., additional, Kim, Theresa B., additional, Kimberling, William J., additional, Koh, Jeffrey, additional, Kokot, Niels, additional, Koltai, Peter J., additional, Kozak, Frederick K., additional, Krakovitz, Paul R., additional, Kridel, Russell W.H., additional, Kumar, Parvesh, additional, Kunduk, Melda, additional, Laccourreye, Ollivier, additional, Lacey, JoAnne, additional, Lai, Stephen Y., additional, Lal, Devyani, additional, Lalwani, Anil K., additional, Lambert, Paul R., additional, Lassig, Amy Anne, additional, Latchaw, Richard E., additional, Leahy, Kevin P., additional, Lee, Daniel J., additional, Lee, Ken K., additional, Lee, Nancy, additional, Lefebvre, Jean-Louis, additional, Lefton-Greif, Maureen A., additional, Leopold, Donald A., additional, Lewis, James S., additional, Li, Daqing, additional, Lian, Timothy S., additional, Licameli, Greg R., additional, Limb, Charles J., additional, Logemann, Jeri A., additional, Loh, Thomas, additional, Lonsbury-Martin, Brenda L., additional, Lopez, Manuel A., additional, Lusk, Rodney P., additional, Lustig, Lawrence R., additional, Lysakowski, Anna, additional, MacArthur, Carol J., additional, Maisel, Robert H., additional, Malone, James P., additional, Mandel, Ellen M., additional, Mandel, Susan J., additional, Manning, Scott C., additional, Mark, Lynette, additional, Markt, Jeffery C., additional, Marsh, Michael, additional, Martin, Glen K., additional, Mattox, Douglas E., additional, McCaffrey, Thomas V., additional, McCulloch, Timothy M., additional, McGee, JoAnn, additional, McGuire, John F., additional, McJunkin, Jonathan, additional, McMurray, J. Scott, additional, Merati, Albert L., additional, Merchant, Saumil N., additional, Messner, Anna H., additional, Michelson, James, additional, Milczuk, Henry A., additional, Minor, Lloyd B., additional, Mobley, Steven Ross, additional, Muntz, Harlan, additional, Murakami, Craig S., additional, Myer, Charles M., additional, Naclerio, Robert M., additional, Nadol, Joseph B., additional, Nassif, Paul S., additional, Nedzelski, Julian, additional, Nicolai, Piero, additional, Nielsen, David R., additional, Niparko, John K., additional, Norton, Susan J., additional, Nouraei, S.A. Reza, additional, Nuss, Daniel W., additional, Nussenbaum, Brian, additional, Odland, Rick M., additional, O'Donoghue, Gerard, additional, Oliver, Eric R., additional, O’Malley, Bert W., additional, O’Reilly, Robert C., additional, Ospina, Juan Camilo, additional, Ossoff, Robert H., additional, Otto, Kristen J., additional, Packer, Mark D., additional, Pallanch, John, additional, Palmer, James N., additional, Park, Stephen S., additional, Patel, Sundip, additional, Patterson, G. Alexander, additional, Pearson, Bruce W., additional, Pellitteri, Phillip K., additional, Perkins, Jonathan A., additional, Perkins, Stephen W., additional, Pero, Colin D., additional, Pignatari, Shirley S.N., additional, Pletcher, Steven D., additional, Popovtzer, Aron, additional, Postma, Gregory N., additional, Potsic, William P., additional, Poznanovic, Sheri A., additional, Quatela, Vito C., additional, Rabinov, C. Rose, additional, Ramachandran, Virginia, additional, Randolph, Gregory W., additional, Rassekh, Christopher H., additional, Rauch, Steven D., additional, Reinisch, Lou, additional, Richardson, Mark, A., additional, Richter, Gresham T., additional, Ridgway, James M., additional, Robbins, K. Thomas, additional, Roediger, Frederick C., additional, Rogers, Jeremy, additional, Ronen, Ohad, additional, Rosenfeld, Richard M., additional, Rotter, Bruce E., additional, Rubinstein, Jay T., additional, Ruckenstein, Michael J., additional, Rumboldt, Zoran, additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Sadoughi, Babak, additional, Salassa, John R., additional, Salinas, Thomas J., additional, Samant, Sandeep, additional, Samlan, Robin A., additional, Samy, Ravi N., additional, Sandel, Henry D., additional, Sandhu, Guri S., additional, Sando, Isamu, additional, Sauder, Cara, additional, Scarlett, Jeremy A., additional, Scher, Richard L., additional, Schessel, David A., additional, Schmalbach, Cecelia E., additional, Schwedt, Todd J., additional, Sciubba, James J., additional, Sequeira, Sunitha, additional, Seshamani, Meena, additional, Shelton, Clough, additional, Shepard, Neil T., additional, Ship, Jonathan A., additional, Shirley, W. Peyton, additional, Shnayder, Yelizaveta, additional, Shvidler, Joseph, additional, Sie, Kathleen C.Y., additional, Simmen, Daniel B., additional, Smith, Marshall E., additional, Smith, Richard J.H., additional, Sofferman, Robert A., additional, Soma, Marlene, additional, Stach, Brad A., additional, Staecker, Hinrich, additional, Stamm, Aldo Cassol, additional, Stankiewicz, James A., additional, Stavinoha, Rose, additional, Sterni, Laura M., additional, Steward, David L., additional, Stocks, Rose Mary S., additional, Sudhoff, Holger H., additional, Sunwoo, John B., additional, Swanson, Neil A., additional, Swanson, Veronica C., additional, Swarm, Robert A., additional, Sykes, Jonathan M., additional, Tan, Luke, additional, Tardy, M. Eugene, additional, Tatum, Sherard A., additional, Taylor, S. Mark, additional, Teissier, Natacha, additional, Telian, Steven A., additional, Terris, David J., additional, Teufert, Karen B., additional, Thomas, J. Regan, additional, Thompson, James N., additional, Toriumi, Dean M., additional, Torres, Alejandro I., additional, Travers, Joseph B., additional, Travers, Susan P., additional, Tsue, Terance T., additional, Tufano, Ralph P., additional, Tunkel, David E., additional, Turner, Michael D., additional, Uppaluri, Ravindra, additional, Vaezi, Michael F., additional, Van den Abbeele, Thierry, additional, van den Brekel, Michiel W.M., additional, Vaysberg, Mikhail, additional, Vokes, David E., additional, Wackym, P. Ashley, additional, Wakefield, Tamekia L., additional, Walner, David L., additional, Walsh, Edward J., additional, Walvekar, Rohan R., additional, Wang, Tom D., additional, Warren, Frank M., additional, Weber, Randal S., additional, Wein, Richard O., additional, Weinstein, Gregory S., additional, Weitzel, Erik Kent, additional, Welling, D. Bradley, additional, Wemer, Richard D., additional, Wetmore, Ralph F., additional, Weymuller, Ernest A., additional, Wiatrak, Brian J., additional, Wiet, Gregory J., additional, Wiggins, Richard H., additional, Willey, Andrea, additional, William, William N., additional, Williams, Glenn B., additional, Wippold, Franz J., additional, Woodson, Gayle Ellen, additional, Woolley, Audie L., additional, Wootten, Christopher T., additional, Wormald, Peter-John, additional, Yingling, Charles D., additional, Yueh, Bevan, additional, Yung, Rex C., additional, Zaldívar, Renzo A., additional, Zalzal, George H., additional, Zee, David S., additional, Zimbler, Marc S., additional, Zinreich, S. James, additional, and Zwolan, Teresa A., additional

Published
2010
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30. Contributors

Author

Adamson, Peter A., primary, Adler, Joshua S., additional, Ali, M. Jafer, additional, Anderson, Susan K., additional, Ashbach, Matthew, additional, Auerbach, Andrew D., additional, Barrs, David, additional, Bhatki, Amol M., additional, Bilsky, Mark H., additional, Boyle, Jay O., additional, Bruley, Mark E., additional, Bumpous, Jeffrey M., additional, Chang, C. Y. Joseph, additional, Chen, Amy Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheung, Steven W., additional, Ciucci, Michelle, additional, Civantos, Francisco J., additional, Cockerham, Kimberly P., additional, Coltrera, Marc D., additional, Courey, Mark S., additional, Craig, Brian, additional, Deschler, Daniel G., additional, Dierdorf, Stephen F., additional, Dowd, Christopher F., additional, Eisele, David W., additional, El-Sayed, Ivan H., additional, Feghali, Joseph G., additional, Ferris, Robert L., additional, Fraioli, Rebecca E., additional, Fried, Marvin P., additional, Gassner, Holger G., additional, Gausas, Roberta E., additional, Genden, Eric M., additional, Gibson, F. Brian, additional, Gillespie, M. Boyd, additional, Goldberg, Andrew N., additional, Goldstein, David P., additional, Gourin, Christine G., additional, Gullane, Patrick J., additional, Haigentz, Missak, additional, Hoffman, Ronald A., additional, Horn, Corinne Elisabeth, additional, Hu, Mimi I., additional, Hullar, Timothy E., additional, Inglis, Andrew F., additional, Irish, Jonathan C., additional, Jackman, Alexis H., additional, Jacobson, Adam S., additional, Johnson, Jonas T., additional, Kashima, Haskins, additional, Kezirian, Eric J., additional, Khabie, Nissim, additional, Kim, David W., additional, Koch, Wayne M., additional, Kölln, Karen A., additional, Kraus, Dennis H., additional, Lambert, Paul R., additional, Lin, Frank R., additional, Lin, Jerry, additional, Little, Jarrod, additional, Lobo, Errol P., additional, Lustig, Lawrence R., additional, McCulloch, Timothy M., additional, McDermott, Michael W., additional, McElveen, John T., additional, Millender, Laura Ellen, additional, Moe, Kris S., additional, Monsein, Lee H., additional, Moore, Eric J., additional, Murakami, Craig S., additional, Murr, Andrew H., additional, Netterville, James L., additional, Niparko, John K., additional, Olsen, Kerry D., additional, Orloff, Lisa A., additional, Ow, Thomas Julian, additional, Parikh, Sanjay R., additional, Parikh, Shatul L., additional, Pellegrini, Francesca, additional, Perkins, Stephen W., additional, Perler, Bruce A., additional, Pitman, Karen T., additional, Pogrel, M. Anthony, additional, Pusceddu, Elisabetta, additional, Rainone, Francine, additional, Reid, Vincent, additional, Resto, Vicente A., additional, Rhodes, Jennifer L., additional, Richardson, Mark A., additional, Saito, David M., additional, Saleh, Hazem Mohammad Ali, additional, Schiff, Bradley A., additional, Schmidt, Brian L., additional, Senior, Brent A., additional, Sherman, Steven I., additional, Shrime, Mark G., additional, Smith, Richard V., additional, Staffenberg, David Alan, additional, Straker, Tracey, additional, Sykes, Jonathan M., additional, Teknos, Theodoros N., additional, Terris, David J., additional, Thedinger, Bradley, additional, Thomas, J. Regan, additional, Wachter, Robert M., additional, Walvekar, Rohan R., additional, Wang, Brian S., additional, Wang, Steven J., additional, Wladis, Edward, additional, Zavod, Matthew B., additional, Zimbler, Mark S., additional, Zoumalan, Christopher I., additional, and Zoumalan, Richard A., additional

Published
2009
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40. Vocal Fold Paresis

Author

Sulica, Lucian, Courey, Mark S., Postma, Gregory N., Garrett, Gaelyn C., Bielamowicz, Steven A., and Merati, Albert L.

Published
2008
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46. Addition of Wendler Glottoplasty to Voice Therapy Improves Trans Female Voice Outcomes.

Author

Brown, Sarah K., Chang, Joseph, Hu, Shirley, Sivakumar, Ganesh, Sataluri, Medha, Goldberg, Leanne, and Courey, Mark S.

Abstract

Objectives/Hypothesis: VT is often considered the preferred treatment for vocal feminization in transgender patients. However, Wendler glottoplasty offers a surgical option for increasing fundamental frequency and perception of vocal femininity. We aimed to determine whether the addition of glottoplasty to VT results in greater fundamental frequency elevation and improvement in quality‐of‐life measures. Study Design: Retrospective case series. Methods: Forty‐eight trans female patients were treated for vocal feminization. Twenty‐seven patients underwent VT, and 21 patients underwent VT with additional glottoplasty (VTWG). Pre‐ and posttreatment acoustic measures, Trans Woman Voice Questionnaire (TWVQ), and Voice Handicap Index‐10 (VHI‐10) data were compared. Results: Glottoplasty in combination with VT elevated average speaking fundamental frequency (SF0) to a greater extent than VT alone (P <.0001). The VTWG group achieved a 42‐Hz increase in SF0, whereas the VT group achieved a 15‐Hz increase in SF0. In both the VT and VTWG groups, the lower bound of physiologic range increased by 18 Hz (P =.0008 and P =.016, respectively). The addition of glottoplasty also resulted in greater improvement in voice‐related quality of life. Improvement in TWVQ and VHI‐10 was significantly greater in the VTWG group than the VT group (P =.007 and P =.029, respectively). TWVQ showed statistically significant improvement in the VTWG group only. Conclusions: VT results in SF0 elevation and improvement in VHI‐10. The addition of glottoplasty to VT results in further improvements in SF0 and VHI‐10 and statistically significant improvement in TWVQ. Level of Evidence: 4 Laryngoscope, 131:1588–1593, 2021 [ABSTRACT FROM AUTHOR]

Published
2021
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