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9 results on '"Courtaut, Flavie"'

7. Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context

Author

Chalons, Pauline, primary, Courtaut, Flavie, additional, Limagne, Emeric, additional, Chalmin, Fanny, additional, Cantos‐Villar, Emma, additional, Richard, Tristan, additional, Auger, Cyril, additional, Chabert, Philippe, additional, Schini‐Kerth, Valérie, additional, Ghiringhelli, François, additional, Aires, Virginie, additional, and Delmas, Dominique, additional

Published
2020
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8. Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages

Author

Chalons, Pauline, Amor, Souheila, Courtaut, Flavie, Cantos-Villar, Emma, Richard, Tristan, Auger, Cyril, Chabert, Philippe, Schni-Kerth, Valérie, Aires, Virginie, Delmas, Dominique, Université de Bourgogne (UB), Equipe CADIR (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Service de Biochimie et de Biologie Moléculaire [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and université de Bourgogne, LNC

Subjects
Lipopolysaccharides, Inflammasomes, red wine extract, Interleukin-1beta, inflammation, interleukins, polyphenols, resveratrol, Anti-Inflammatory Agents, Wine, lcsh:TX341-641, Article, Cell Line, Mice, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Plant Extracts, Macrophages, food and beverages, CARD Signaling Adaptor Proteins, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, RAW 264.7 Cells, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, lcsh:Nutrition. Foods and food supply, Phytotherapy
Abstract

Inflammation has been described as an initiator event of major diseases with significant impacts in terms of public health including in cardiovascular disease, autoimmune disorders, eye diseases, age-related diseases, and the occurrence of cancers. A preventive action to reduce the key processes leading to inflammation could be an advantageous approach to reducing these associated pathologies. Many studies have reported the value of polyphenols such as resveratrol in counteracting pro-inflammatory cytokines. We have previously shown the potential of red wine extract (RWE) and the value of its qualitative and quantitative polyphenolic composition to prevent the carcinogenesis process. In this study, we addressed a new effect of RWE in inflammation through a modulation of IL-1&beta, secretion and the NLRP3 inflammasome pathway. NLRP3 inflammasome requires two signals, priming to increase the synthesis of NLRP3 and pro-IL-1&beta, proteins and activation, which activates NLRP3. Inflammasome formation is triggered by a range of substances such as lipopolysaccharide (LPS). Using two different macrophages, one of which does not express the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which is essential to form active inflammasome complexes that produce IL-1&beta, we show that RWE decreases IL-1 &beta, secretion and gene expression whatever line is used. Moreover, this strong reduction of pro-inflammatory IL-1&beta, is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin.

Published
2018
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9. Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

Author

Courtaut, Flavie, primary, Derangère, Valentin, additional, Chevriaux, Angélique, additional, Ladoire, Sylvain, additional, Cotte, Alexia K., additional, Arnould, Laurent, additional, Boidot, Romain, additional, Rialland, Mickaël, additional, Ghiringhelli, François, additional, and Rébé, Cédric, additional

Published
2015
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