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2. Status Epilepticus in Children

Author

Covanis, Athanasios, primary, Garganis, Kyriakos, additional, Mesraoua, Boulenouar, additional, Hosni Khodair, Rola, additional, K.M. Abumustafa, Rasha, additional, and Thekkumpurath, Thahira, additional

Published
2023
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4. Periodic EEG Patterns in the Intensive Care Unit (ICU): Definition, Recognition and Clinical Significance

Author

Mesraoua, Boulenouar, primary, Abdalhalim Ali, Musab, additional, Hosni Mohamed Hashem Khodair, Rola, additional, Nofal, Yazan, additional, Theophiel O. Deleu, Dirk, additional, Jasim Al Hail, Hassan, additional, Robin Elalamy, Osama, additional, Melikyan, Gayane, additional, Athanasios, Covanis, additional, and Akbar Asadi-Pooya, Ali, additional

Published
2021
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5. List of Contributors

Author

Aaen, Gregory, primary, Abroms, Israel F., additional, Ådén, Ulrika, additional, Ahlsten, Gunnar, additional, Aird, Robert B., additional, Al-Zaidy, Samiah A., additional, Andermann, Fred, additional, Anlar, Banu, additional, Arzimanoglou, Alexis, additional, Ashwal, Stephen, additional, Augustine, Erika, additional, Ballaban-Gil, Karen, additional, Bamford, Nigel S., additional, Barlow, Charles F., additional, Bast, Thomas, additional, Bates, David, additional, Baumann, Robert J., additional, Bertini, Enrico, additional, Beya, Alidor, additional, Blaw, Michael, additional, Bodensteiner, John, additional, Bonthius, Daniel J., additional, Brin, Amy E., additional, Brockmann, Knut, additional, Brown, John Keith, additional, Brown, Stuart B., additional, Brumback, Audrey Christine, additional, Bureau, Michelle, additional, Burke, James R., additional, Bye, Annie, additional, Camfield, Carol, additional, Camfield, Peter, additional, Campistol Plana, Jaume, additional, Canale, Dee James, additional, Caneris, Onasis, additional, Caraballo, Roberto H., additional, Caviness, Alison Chantal, additional, Chao, Hsiao-Tuan, additional, Chapman, Catherine A., additional, Chaves-Carballo, Enrique, additional, Cho, Yoon-Jae, additional, Christen, Hans-Jürgen, additional, Chugani, Harry T., additional, Cioni, Giovanni, additional, Clark, David, additional, Cliff, Edward Robert Scheffer, additional, Cochran, Frederick B., additional, Cohen, Bruce H., additional, Cohen, Maynard M., additional, Collins, Kevin, additional, Covanis, Athanasios, additional, Critchley, Macdonald, additional, Cross, J. Helen, additional, Crumrine, Patricia K., additional, Curatolo, Paolo, additional, Davies, Pamela A., additional, deVeber, Gabrielle, additional, De Vivo, Darryl C., additional, de Vries, Linda S., additional, De Waele, Liesbeth, additional, DeMyer, William, additional, Devlin, Anita, additional, Dobyns, William B., additional, Dodson, W. Edwin, additional, Donald, Kirsty, additional, Duffy, Frank H., additional, Dunn, David W., additional, Dunn, Henry G., additional, Dure, Leon S., additional, Dyken, Paul Richard, additional, Encha-Razavi, Férechté, additional, Erenberg, Gerald, additional, Estes, Melinda L., additional, Evrard, Philippe, additional, Ferriero, Donna, additional, Ferry, Peggy, additional, Fine, Archie, additional, Fine, Edward J., additional, Fine, John S., additional, Finkel, Richard S., additional, Fischer, Alain, additional, Fischer, Christine, additional, Fogan, Lance, additional, Fowler, Glenn W., additional, Frank, Yitzchak, additional, Fullerton, Heather J., additional, Furukawa, Tetsuo, additional, Gabriel, Ronald S., additional, Galanopoulou, Aristea S., additional, Gardner-Medwin, David, additional, Garg, Bhuwan, additional, Genton, Pierre, additional, George, Mark S., additional, Gineste, Thierry, additional, Giza, Christopher C., additional, Goemans, Nathalie, additional, Golden, Gerald S., additional, Golden, Jeffrey Alan, additional, Goldstein, Gary W., additional, Gomez, Christopher, additional, Gomez, Manuel R., additional, Gomez, Timothy, additional, Goodkin, Howard P., additional, Gordon, Neil, additional, Gressens, Pierre, additional, Groger, Helmut, additional, Guerrini, Renzo, additional, Gurnett, Christina A., additional, Gussoni, Emanuela, additional, Haas, Richard, additional, Hagberg, Bengt, additional, Haller, Jerome S., additional, Hartman, Adam L., additional, Haruda, Fred, additional, Hirtz, Deborah, additional, Hogan, Gwendolyn R., additional, Hunt, Guy M., additional, Iannaccone, Susan T., additional, Eleanor Inder, Terrie, additional, Ionasescu, Victor, additional, Jansen, Katrien, additional, Jiang, Yuwu, additional, Kaminski, Henry J., additional, Kamoshita, Shigehiko, additional, Kang, Peter B., additional, Kaufman, David M., additional, Kaufmann, Walter E., additional, Kaye, Edward M., additional, Kellaway, Peter, additional, Kelley, Rhona S., additional, Kennedy, Charles, additional, Kim, Young-Min, additional, Kirby, Michael, additional, Kirton, Adam, additional, Kobayashi, Eliane, additional, Kossoff, Eric H., additional, Koutroumanidis, Michail, additional, Krupp, Lauren, additional, Lange, Bernadette M., additional, Lanska, Douglas J., additional, Lanska, Mary Jo, additional, Larsen, Paul D., additional, Lassoff, Samuel J., additional, Laterra, John, additional, Lemieux, Bernard, additional, Lenn, Nicholas J., additional, Logan, William J., additional, Lomax, Elizabeth, additional, Longo, Lawrence D., additional, Lorris Betz, A., additional, Manyam, Bala V., additional, Marks, Warren A., additional, Massey, E. Wayne, additional, Mate, Laszlo J., additional, McKinlay, Ian, additional, McLean, William T., additional, McLellan, Ailsa, additional, Mehler, Mark F., additional, Melchior, Johannes C., additional, Michelson, David J., additional, Miller, Steven P., additional, Miller, Suzanne L., additional, Millichap, J. Gordon, additional, Minns, Robert A., additional, Mizrahi, Eli M., additional, Moser, Ann B., additional, Moshé, Solomon L., additional, Muhle, Hiltrud, additional, Muntoni, Francesco, additional, Naidu, Sakkubai, additional, Narayanan, Vinodh, additional, Nardocci, Nardo, additional, Neil, Jeffrey J., additional, Neumeyer, Ann, additional, Noetzel, Michael J., additional, Nomura, Yoshiko, additional, Nordli, Douglas R., additional, North, Kathryn, additional, Ohtsuka, Yoko, additional, O’Callaghan, Finbar J.K., additional, Packer, Roger J., additional, Pastores, Gregory M., additional, Patterson, Marc C., additional, Pearl, Phillip L., additional, Philippart, Michel, additional, Pihko, Helena S., additional, Piller, Gordon, additional, Platz, Thomas F., additional, Poduri, Annapurna, additional, Pollack, Michael A., additional, Porter, Brenda E., additional, Provis, Michèle, additional, Rating, Dietz, additional, Reich, Harold, additional, Remler, Bernd, additional, Rho, Jong M., additional, Richards, Peter, additional, Richardson, Edward P., additional, Richardson, Sylvia O., additional, Roach, E. Steve, additional, Rose, Arthur L., additional, Rozear, Marvin P., additional, Rubinstein, Lucien J., additional, Rust, Robert S., additional, Saini, Arushi Gahlot, additional, Saint-Anne Dargassies, Suzanne, additional, Sarnat, Harvey B., additional, Sarwar, Mohammad, additional, Satran, Richard, additional, Schneider, Sanford, additional, Schrank, Waltraud, additional, Scott, Rodney C., additional, Seinfeld, Syndi, additional, Selcen, Duygu, additional, Sestan, Nenad, additional, Shapiro, Steven, additional, Sherr, Elliott H., additional, Shevell, Michael, additional, Shield, Lloyd, additional, Sidman, Richard L., additional, Silverstein, Faye S., additional, Sinnreich, Michael, additional, Snead, O. Carter, additional, Solomons, Regan, additional, Soria-Duran, Emilio, additional, Stafstrom, Carl E., additional, Steven Roach, E., additional, Stevens, Harold, additional, Strassburg, Hans Michael, additional, Stumpf, David A., additional, Sullivan, Thomas, additional, Swick, Herbert M., additional, Swisher, Charles N., additional, Takahashi, Takao, additional, Tein, Ingrid, additional, Tochen, Laura, additional, Thomas, Eva E., additional, Thompson, Alan, additional, Toor, Svinder S., additional, Tyler, H. Richard, additional, Uldall, Peter, additional, Urion, David K., additional, Valappil, Ahsan Moosa Naduvil, additional, Van Toorn, Ronald, additional, Vermilion, Jennifer, additional, Vidaver, Doris, additional, Vohr, Betty R., additional, Vollmer, Brigitte, additional, Volpe, Joseph J., additional, Waber, Deborah P., additional, Wainwright, Mark S., additional, Waites, Lucius, additional, Walsh, Christopher, additional, Weindl, Adolf, additional, Whelan, Mary Anne, additional, White, Larry E., additional, Whittemore, Vicky Holets, additional, Wilmshurst, Jo, additional, Wirrell, Elaine, additional, Wolf, Nicole I., additional, Youssef, Paul, additional, Zempel, John, additional, Zoghbi, Huda Y., additional, Zuberi, Sameer M., additional, and Zupanc, Mary, additional

Published
2021
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8. Epilepsy and Cerebral Palsy

Author

Mesraoua, Boulenouar, primary, Ali, Musab, additional, Deleu, Dirk, additional, Al Hail, Hassan, additional, Melikyan, Gayane, additional, Haddad, Naim, additional, Alalamy, Osama, additional, Athanasios, Covanis, additional, and A. Asadi-Pooya, Ali, additional

Published
2019
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11. Clinical and genetic analysis of a family with two rare reflex epilepsies

Author

Kasteleijn-Nolst Trenité, Dorothée G.A., Volkers, Linda, Strengman, Eric, Schippers, Herman M., Perquin, Willem, de Haan, Gerrit-Jan, Gkountidi, Anastasia O., Slot, Ruben van’t, van de Graaf, Stan F., Jocic-Jakubi, Bosanka, Capovilla, Giuseppe, Covanis, Athanasios, Parisi, Pasquale, Veggiotti, Pierangelo, Brinciotti, Mario, Incorpora, Gemma, Piccioli, Marta, Cantonetti, Laura, Berkovic, Samuel F., Scheffer, Ingrid E., Brilstra, Eva H., Sonsma, Anja C.M., Bader, Adri J., de Kovel, Carolien G.F., and Koeleman, Bobby P.C.

Published
2015
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12. Brain-Heart Link in Schizophrenia: Cognitive Inhibitory Control Deficit in Patients Is Specifically Related to Parasympathetic Dysregulation

Author

Marina Lazaridi, Georgia Panagiotaropoulou, Panagiotis Covanis, Thomas Karantinos, Elias Aggelopoulos, Christoph Klein, and Nikolaos Smyrnis

Subjects
Psychiatry and Mental health, Cognition, Heart Rate, Schizophrenia, Brain, Humans, Cognitive Dysfunction
Abstract

Background This study examined the connection between two prominent deficits in schizophrenia: the deficit in parasympathetic regulation and the deficit in cognitive inhibitory control, within the framework of the Neurovisceral Integration Model (NIM). Study Design Thirty healthy controls and 30 patients with schizophrenia performed the internationally standardized antisaccade protocol while their electrocardiographic data were recorded. The interaction between the group, the cognitive inhibitory control as measured with error rate (ER) in the antisaccade task and parasympathetic activity as measured with the High Frequency power component of Heart Rate Variability (HF-HRV) was tested. Study Results Findings confirmed that decreased HF-HRV was specifically related to increased ER in patients with schizophrenia. In contrast, patient deficits in other oculomotor function measures such as reaction time and reaction time variability related to volitional movement control and cognitive stability respectively were not linked to the deficit in parasympathetic regulation. Conclusions Our study validates the theory behind NIM proposing that cognitive inhibition has common physiological substrate with parasympathetic regulation. Future research could test this brain-heart link in other mental disorders especially those with a prominent deficit in inhibitory cognitive function.

Published
2022
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13. Status Epilepticus in Children

Author

Athanasios, Covanis, Kyriakos, Garganis, Boulenouar, Mesraoua, Hosni, Khodair, Rola, K.M., Abumustafa, Rasha, and Thahira, Thekkumpurath

Abstract

Status epilepticus (SE) is an acute, one of the most common, life threatening emergency condition in children and adolescence. According to the ILAE commission, SE is defined as a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures. Regarding duration, ILAE defines convulsive SE as bilateral tonic–clonic lasting longer that 5 minutes, and absence and focal status epilepticus as exceeding 10 minutes. Children compared to adults are more prone to epileptic seizures and as a consequence to SE, mainly due to age related maturational imbalance between excitatory and inhibitory synaptic mechanisms. The classification into generalised or focal, convulsive and nonconvulsive differ widely in aetiology, management and outcome. Early prehospital intervention with appropriate protective measures and emergency medication of seizure disorder, may prevent perpetuation of seizure recurrence. If first line treatment fails and or event, emergency hospital admission should be provided for more aggressive intravenous therapy, assessment-support.

Published
2023
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14. Multisensory integration deficits in Schizophrenia and Autism evidenced in behaviour but not sensory related event related potentials

Author

Maida Toumaian, Panagiotis Covanis, Asimakis Mantas, Thomas Karantinos, Sergios Kayas, Anna Kentikeleni, Argiro Vatakis, Christoph Klein, and Nikolaos Smyrnis

Abstract

The process of integrating information from different sensory channels, known as multisensory integration (MSI) was assessed in two disorders, Autism Spectrum Disorder (ASD) and Schizophrenia (SCZ). 32 healthy controls (HC), 35 SCZ patients, and 23 ASD patients performed a synchronous target detection task using auditory (A), visual (V), and audiovisual (AV) stimuli, while reaction times (RT) and scalp recorded electrophysiological (EEG) activity were measured. MSI in the AV condition resulted in faster and less variable RTs compared to the unimodal conditions. Using a novel method to identify MSI gain in RT at the level of the individual subject, MSI gain was observed in 78% of HC, 26% of ASD, and 48% of SCZ patients. At the neural level, MSI in the AV condition resulted in larger amplitude of sensory evoked responses (N1 and P2 compared to the A condition, P1 and N2 compared to the V condition) and cognitive P3 response (compared to both unimodal conditions). These neural effects of MSI were not related to the behavioural MSI gain identified at the individual level. Furthermore, they could not explain the deficits in behavioural MSI of patient groups. In conclusion, a robust MSI gain deficit in RT was observed in both patient groups that was not reflected in early perceptual and cognitive electro-cortical responses, suggesting that behavioural MSI deficits in ASD and SCZ may arise at late processing stages such as response selection.

Published
2023
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21. Workshops

Author

Belfer, Myron, Tyano, Sam, Manor, I., Lombroso, Paul, State, Matthew, Yosse, Jocelyn Hattab, Hattab, Jocelyn, Pfeffer, Cynthia, Takaoka, Ken, Donnelly, Craig, Harper, Gordon, Çetin, Füsun Çuhadaroólu, Cheng, Wenhong, Polnareva, Nadia, Celia, Salvador, Breger, Eli, Vermeiren, Robert, Leestmans, Dirk, Mächtlinger, Veronica, Hartmann, Erika, Fellinger, Johannes, Canitano, Roberto, Speranza, Mario, Pejovic-Milovancevic, Milica, Aleksic, Olivera, Tsalamanios, Emmanouel, Hatzara, V., Zacharaki, L., Andriotis, L., Covanis, A., Tsiantis, John, Herman, Barry, Fegert, Jörg M., Bailey, Sue, der Marwitz, Gudrun Fischer-von, Schneider, Andrea, Kelleter, Renate, Keren, Mirelle, Jensen, Peter, Wharton, Paul, Remschmidt, Helmut, editor, and Belfer, Myron L., editor

Published
2004
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22. Absence-to-bilateral-tonic-clonic seizure

Author

Sándor Beniczky, Guido Rubboli, Michael R. Sperling, and Athanasios Covanis

Subjects
Adult, Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Adolescent, Clonic seizure, Electroencephalography, Article, Tonic (physiology), Young Adult, 03 medical and health sciences, 0302 clinical medicine, Seizures, medicine, Humans, Ictal, Child, medicine.diagnostic_test, business.industry, Generalized seizure, Middle Aged, 030104 developmental biology, Tonic-clonic seizures, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

ObjectiveTo test the hypothesis that absence seizures can evolve to generalized tonic-clonic seizures, we documented electroclinical features of this novel seizure type.MethodsIn 4 large video-EEG databases, we identified recordings of seizures starting with impaired awareness that, without returning to baseline interictal state, evolved to generalized tonic-clonic seizures. We extracted the detailed semiologic and electrographic characteristics of these seizures, and we documented the clinical background, diagnoses, and therapeutic responses in these patients.ResultsWe identified 12 seizures from 12 patients. All seizures started with a period of impaired awareness and bursts of generalized spike or polyspike and slow-wave discharges, the hallmark of absence seizures. Without returning to baseline, the nonmotor (absence) phase was followed by tonic-clonic convulsions. We called this novel generalized seizure type absence-to-bilateral-tonic-clonic seizure. Most patients had idiopathic generalized epilepsies, although with a high incidence of unusual features and poor therapeutic response.ConclusionsAbsence-to-bilateral-tonic-clonic seizures are a novel generalized seizure type. Clinicians should be aware of this seizure for correctly diagnosing patients. This novel seizure type may further elucidate generalized ictogenesis.

Published
2020
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23. Brain-Heart Link in Schizophrenia: Cognitive Inhibitory Control Deficit in Patients Is Specifically Related to Parasympathetic Dysregulation

Author

Lazaridi, Marina, Panagiotaropoulou, Georgia, Covanis, Panagiotis, Karantinos, Thomas, Aggelopoulos, Elias, Klein, Christoph, Smyrnis, Nikolaos, Lazaridi, Marina, Panagiotaropoulou, Georgia, Covanis, Panagiotis, Karantinos, Thomas, Aggelopoulos, Elias, Klein, Christoph, and Smyrnis, Nikolaos

Abstract

Background This study examined the connection between two prominent deficits in schizophrenia: the deficit in parasympathetic regulation and the deficit in cognitive inhibitory control, within the framework of the Neurovisceral Integration Model (NIM). Study Design Thirty healthy controls and 30 patients with schizophrenia performed the internationally standardized antisaccade protocol while their electrocardiographic data were recorded. The interaction between the group, the cognitive inhibitory control as measured with error rate (ER) in the antisaccade task and parasympathetic activity as measured with the High Frequency power component of Heart Rate Variability (HF-HRV) was tested. Study Results Findings confirmed that decreased HF-HRV was specifically related to increased ER in patients with schizophrenia. In contrast, patient deficits in other oculomotor function measures such as reaction time and reaction time variability related to volitional movement control and cognitive stability respectively were not linked to the deficit in parasympathetic regulation. Conclusions Our study validates the theory behind NIM proposing that cognitive inhibition has common physiological substrate with parasympathetic regulation. Future research could test this brain-heart link in other mental disorders especially those with a prominent deficit in inhibitory cognitive function.

Published
2022

24. RECOMMENDATIONS FOR DIAGNOSTICS AND TREATMENT OF NIEMANN-PICK TYPE C DISEASE

Author

James E. Wraith, Matthias R. Baumgartner, Bruno Bembi, Athanasios Covanis, Thierry Levade, Eugen Mengel, Merce Pineda, Frederic Sedel, Meral Topcu, Marie T. Vanier, Hakan Widner, Frits A. Wijburg, and Marc C. Pattersonm

Subjects
Pediatrics, RJ1-570, Therapeutics. Pharmacology, RM1-950
Abstract

(Pediatric Pharmacology. – 2010; 7(1):16-24)

Published
2010

27. Exploring the prevalence and profile of epilepsy across Europe using a standard retrospective chart review:Challenges and opportunities

Author

Linehan, Christine, Benson, Ailbhe, Gunko, Alex, Christensen, Jakob, Sun, Yuelian, Tomson, Torbjorn, Marson, Anthony, Forsgren, Lars, Trinka, Eugen, Iliescu, Catrinel, Althoehn Sonderup, Julie, Dreier, Julie Werenberg, Sandu, Carmen, Leanca, Madalina, Rainer, Lucas, Kobulashvili, Teia, Granbichler, Claudia A., Delanty, Norman, Doherty, Colin, Staines, Anthony, Shahwan, Amre, Baker, Gus, Bolger, Eve, Jennum, Poul Jorgen, Ilescu, Catrinel, Malmgren, Kristina, Kjellberg, Jakob, Kerr, Michael, Covanis, Athanasios, Sales, Francisco, Mameniskiene, Ruta, Ekman, Mattias, Ryvlin, Philippe, Holmgaard, Marie Normark, and Granbichler, Claudia

Subjects
medicine.medical_specialty, Neurologi, Legislation, burden of disease, general data protection regulation, Epilepsy, Documentation, Seizures, Epidemiology, medicine, Prevalence, data protection, epidemiology, GDPR, medical records, Humans, Case report form, Retrospective Studies, business.industry, Medical record, medicine.disease, Europe, Neurology, Family medicine, Etiology, Neurology (clinical), Suspect, business
Abstract

OBJECTIVE: This study aimed to determine the prevalence of epilepsy in four European countries (Austria, Denmark, Ireland, and Romania) employing a standard methodology. The study was conducted under the auspices of ESBACE (European Study on the Burden and Care of Epilepsy).METHODS: All hospitals and general practitioners serving a region of at least 50 000 persons in each country were asked to identify patients living in the region who had a diagnosis of epilepsy or experienced a single unprovoked seizure. Medical records were accessed, where available, to complete a standardized case report form. Data were sought on seizure frequency, seizure type, investigations, etiology, comorbidities, and use of antiseizure medication. Cases were validated in each country, and the degree of certainty was graded as definite, probable, or suspect cases.RESULTS: From a total population of 237 757 in the four countries, 1988 (.8%) patients were identified as potential cases of epilepsy. Due to legal and ethical issues in the individual countries, medical records were available for only 1208 patients, and among these, 113 had insufficient clinical information. The remaining 1095 cases were classified as either definite (n = 706, 64.5%), probable (n = 191, 17.4%), suspect (n = 153, 14.0%), or not epilepsy (n = 45, 4.1%).SIGNIFICANCE: Although a precise prevalence estimate could not be generated from these data, the study found a high validity of epilepsy classification among evaluated cases (95.9%). More generally, this study highlights the significant challenges facing epidemiological research methodologies that are reliant on patient consent and retrospective chart review, largely due to the introduction of data protection legislation during the study period. Documentation of the epilepsy diagnosis was, in some cases, relatively low, indicating a need for improved guidelines for assessment, follow-up, and documentation. This study highlights the need to address the concerns and requirements of recruitment sites to engage in epidemiological research.

Published
2021
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28. Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14

Author

Chioza, Barry A., Aicardi, Jean, Aschauer, Harald, Brouwer, Oebele, Callenbach, Petra, Covanis, Athanasios, Dooley, Joseph M., Dulac, Olivier, Durner, Martina, Eeg-Olofsson, Orvar, Feucht, Martha, Friis, Mogens Laue, Guerrini, Renzo, Kjeldsen, Marianne Juel, Nabbout, Rima, Nashef, Lina, Sander, Thomas, Sirén, Auli, Wirrell, Elaine, McKeigue, Paul, Robinson, Robert, Gardiner, R. Mark, and Everett, Kate V.

Published
2009
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31. CHD2 variants are a risk factor for photosensitivity in epilepsy

Author

Galizia, Elizabeth C., Myers, Candace T., Leu, Costin, de Kovel, Carolien G. F., Afrikanova, Tatiana, Cordero-Maldonado, Maria Lorena, Martins, Teresa G., Jacmin, Maxime, Drury, Suzanne, Krishna Chinthapalli, V., Muhle, Hiltrud, Pendziwiat, Manuela, Sander, Thomas, Ruppert, Ann-Kathrin, Møller, Rikke S., Thiele, Holger, Krause, Roland, Schubert, Julian, Lehesjoki, Anna-Elina, Nürnberg, Peter, Lerche, Holger, Palotie, Aarno, Coppola, Antonietta, Striano, Salvatore, Gaudio, Luigi Del, Boustred, Christopher, Schneider, Amy L., Lench, Nicholas, Jocic-Jakubi, Bosanka, Covanis, Athanasios, Capovilla, Giuseppe, Veggiotti, Pierangelo, Piccioli, Marta, Parisi, Pasquale, Cantonetti, Laura, Sadleir, Lynette G., Mullen, Saul A., Berkovic, Samuel F., Stephani, Ulrich, Helbig, Ingo, Crawford, Alexander D., Esguerra, Camila V., Kasteleijn-Nolst Trenité, Dorothee G. A., Koeleman, Bobby P. C., Mefford, Heather C., Scheffer, Ingrid E., and Sisodiya, Sanjay M.

Published
2015
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32. Periodic EEG Patterns in the Intensive Care Unit (ICU): Definition, Recognition and Clinical Significance

Author

Yazan Nofal, Osama Elalamy, Covanis Athanasios, Boulenouar Mesraoua, Hassan Jasim Al Hail, Rola Khodair, Ali A. Asadi-Pooya, Musab Ali, Dirk Deleu, and Gayane Melikyan

Subjects
medicine.medical_specialty, business.industry, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, 05 social sciences, Intensive care unit, 050105 experimental psychology, Eeg patterns, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, medicine, 0501 psychology and cognitive sciences, Clinical significance, Intensive care medicine, business, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 030217 neurology & neurosurgery
Abstract

Periodic electroencephalographic (EEG) patterns are frequently recorded during ICU EEG monitoring in patients with altered mental status; these EEG features represent electrical discharges, ictal in appearance, occuring at regular intervals. They are known as lateralized periodic discharges (LPDs), bilateral independent periodic discharges (BIPDS), generalized periodic discharges (GPDs), continuous 2/s GPDs with triphasic morphology or triphasic waves (TWs) and Stimulus Induced Evolving Lateralized Rhytmic delta activity or Si-Evolving LRDA (previously SIRPIDS); other periodic, rhythmic patterns are Occasional frontally predominant brief 2/s GRDA (FIRDA previously), Lateralized rhythmic delta activity (LRDA) and Brief potentially ictal rhythmic discharges or B (I)RDs. The role of most (not all) of these EEG patterns is controversial; there is no consensus on which patterns are associated with ongoing seizure injury, which patterns need to be treated, and how aggressively they should be treated. Many authors consider these patterns as an unstable state on an ictal-interictal EEG continuum; the aim of the present chapter is to gain knowledge of these EEG features, show their association with known neurologic pathologies/syndromes and finally how to manage them.

Published
2021
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35. List of Contributors

Author

Gregory Aaen, Israel F. Abroms, Ulrika Ådén, Gunnar Ahlsten, Robert B. Aird, Samiah A. Al-Zaidy, Fred Andermann, Banu Anlar, Alexis Arzimanoglou, Stephen Ashwal, Erika Augustine, Karen Ballaban-Gil, Nigel S. Bamford, Charles F. Barlow, Thomas Bast, David Bates, Robert J. Baumann, Enrico Bertini, Alidor Beya, Michael Blaw, John Bodensteiner, Daniel J. Bonthius, Amy E. Brin, Knut Brockmann, John Keith Brown, Stuart B. Brown, Audrey Christine Brumback, Michelle Bureau, James R. Burke, Annie Bye, Carol Camfield, Peter Camfield, Jaume Campistol Plana, Dee James Canale, Onasis Caneris, Roberto H. Caraballo, Alison Chantal Caviness, Hsiao-Tuan Chao, Catherine A. Chapman, Enrique Chaves-Carballo, Yoon-Jae Cho, Hans-Jürgen Christen, Harry T. Chugani, Giovanni Cioni, David Clark, Edward Robert Scheffer Cliff, Frederick B. Cochran, Bruce H. Cohen, Maynard M. Cohen, Kevin Collins, Athanasios Covanis, Macdonald Critchley, J. Helen Cross, Patricia K. Crumrine, Paolo Curatolo, Pamela A. Davies, Gabrielle deVeber, Darryl C. De Vivo, Linda S. de Vries, Liesbeth De Waele, William DeMyer, Anita Devlin, William B. Dobyns, W. Edwin Dodson, Kirsty Donald, Frank H. Duffy, David W. Dunn, Henry G. Dunn, Leon S. Dure, Paul Richard Dyken, Férechté Encha-Razavi, Gerald Erenberg, Melinda L. Estes, Philippe Evrard, Donna Ferriero, Peggy Ferry, Archie Fine, Edward J. Fine, John S. Fine, Richard S. Finkel, Alain Fischer, Christine Fischer, Lance Fogan, Glenn W. Fowler, Yitzchak Frank, Heather J. Fullerton, Tetsuo Furukawa, Ronald S. Gabriel, Aristea S. Galanopoulou, David Gardner-Medwin, Bhuwan Garg, Pierre Genton, Mark S. George, Thierry Gineste, Christopher C. Giza, Nathalie Goemans, Gerald S. Golden, Jeffrey Alan Golden, Gary W. Goldstein, Christopher Gomez, Manuel R. Gomez, Timothy Gomez, Howard P. Goodkin, Neil Gordon, Pierre Gressens, Helmut Groger, Renzo Guerrini, Christina A. Gurnett, Emanuela Gussoni, Richard Haas, Bengt Hagberg, Jerome S. Haller, Adam L. Hartman, Fred Haruda, Deborah Hirtz, Gwendolyn R. Hogan, Guy M. Hunt, Susan T. Iannaccone, Terrie Eleanor Inder, Victor Ionasescu, Katrien Jansen, Yuwu Jiang, Henry J. Kaminski, Shigehiko Kamoshita, Peter B. Kang, David M. Kaufman, Walter E. Kaufmann, Edward M. Kaye, Peter Kellaway, Rhona S. Kelley, Charles Kennedy, Young-Min Kim, Michael Kirby, Adam Kirton, Eliane Kobayashi, Eric H. Kossoff, Michail Koutroumanidis, Lauren Krupp, Bernadette M. Lange, Douglas J. Lanska, Mary Jo Lanska, Paul D. Larsen, Samuel J. Lassoff, John Laterra, Bernard Lemieux, Nicholas J. Lenn, William J. Logan, Elizabeth Lomax, Lawrence D. Longo, A. Lorris Betz, Bala V. Manyam, Warren A. Marks, E. Wayne Massey, Laszlo J. Mate, Ian McKinlay, William T. McLean, Ailsa McLellan, Mark F. Mehler, Johannes C. Melchior, David J. Michelson, Steven P. Miller, Suzanne L. Miller, J. Gordon Millichap, Robert A. Minns, Eli M. Mizrahi, Ann B. Moser, Solomon L. Moshé, Hiltrud Muhle, Francesco Muntoni, Sakkubai Naidu, Vinodh Narayanan, Nardo Nardocci, Jeffrey J. Neil, Ann Neumeyer, Michael J. Noetzel, Yoshiko Nomura, Douglas R. Nordli, Kathryn North, Yoko Ohtsuka, Finbar J.K. O’Callaghan, Roger J. Packer, Gregory M. Pastores, Marc C. Patterson, Phillip L. Pearl, Michel Philippart, Helena S. Pihko, Gordon Piller, Thomas F. Platz, Annapurna Poduri, Michael A. Pollack, Brenda E. Porter, Michèle Provis, Dietz Rating, Harold Reich, Bernd Remler, Jong M. Rho, Peter Richards, Edward P. Richardson, Sylvia O. Richardson, E. Steve Roach, Arthur L. Rose, Marvin P. Rozear, Lucien J. Rubinstein, Robert S. Rust, Arushi Gahlot Saini, Suzanne Saint-Anne Dargassies, Harvey B. Sarnat, Mohammad Sarwar, Richard Satran, Sanford Schneider, Waltraud Schrank, Rodney C. Scott, Syndi Seinfeld, Duygu Selcen, Nenad Sestan, Steven Shapiro, Elliott H. Sherr, Michael Shevell, Lloyd Shield, Richard L. Sidman, Faye S. Silverstein, Michael Sinnreich, O. Carter Snead, Regan Solomons, Emilio Soria-Duran, Carl E. Stafstrom, E. Steven Roach, Harold Stevens, Hans Michael Strassburg, David A. Stumpf, Thomas Sullivan, Herbert M. Swick, Charles N. Swisher, Takao Takahashi, Ingrid Tein, Laura Tochen, Eva E. Thomas, Alan Thompson, Svinder S. Toor, H. Richard Tyler, Peter Uldall, David K. Urion, Ahsan Moosa Naduvil Valappil, Ronald Van Toorn, Jennifer Vermilion, Doris Vidaver, Betty R. Vohr, Brigitte Vollmer, Joseph J. Volpe, Deborah P. Waber, Mark S. Wainwright, Lucius Waites, Christopher Walsh, Adolf Weindl, Mary Anne Whelan, Larry E. White, Vicky Holets Whittemore, Jo Wilmshurst, Elaine Wirrell, Nicole I. Wolf, Paul Youssef, John Zempel, Huda Y. Zoghbi, Sameer M. Zuberi, and Mary Zupanc

Published
2021
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38. Linkage and mutational analysis of CLCN2 in childhood absence epilepsy

Author

Everett, Kate, Chioza, Barry, Aicardi, Jean, Aschauer, Harald, Brouwer, Oebele, Callenbach, Petra, Covanis, Athanasios, Dooley, Joseph, Dulac, Olivier, Durner, Martina, Eeg-Olofsson, Orvar, Feucht, Martha, Friis, Mogens, Guerrini, Renzo, Heils, Armin, Kjeldsen, Marianne, Nabbout, Rima, Sander, Thomas, Wirrell, Elaine, McKeigue, Paul, Robinson, Robert, Taske, Nichole, and Gardiner, Mark

Published
2007
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41. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies

Author

Leu, Costin, de Kovel, Carolien G.F., Zara, Federico, Striano, Pasquale, Pezzella, Marianna, Robbiano, Angela, Bianchi, Amedeo, Bisulli, Francesca, Coppola, Antonietta, Giallonardo, Anna Teresa, Beccaria, Francesca, Trenité, Dorothée Kasteleijn-Nolst, Lindhout, Dick, Gaus, Verena, Schmitz, Bettina, Janz, Dieter, Weber, Yvonne G., Becker, Felicitas, Lerche, Holger, Kleefu-Lie, Ailing A., Hallman, Kerstin, Kunz, Wolfram S., Elger, Christian E., Muhle, Hiltrud, Stephani, Ulrich, Mller, Rikke S., Hjalgrim, Helle, Mullen, Saul, Scheffer, Ingrid E., Berkovic, Samuel F., Everett, Kate V., Gardiner, Mark R., Marini, Carla, Guerrini, Renzo, Lehesjoki, Anna-Elina, Siren, Auli, Nabbout, Rima, Baulac, Stephanie, Leguern, Eric, Serratosa, Jose M., Rosenow, Felix, Feucht, Martha, Unterberger, Iris, Covanis, Athanasios, Suls, Arvid, Weckhuysen, Sarah, Kaneva, Radka, Caglayan, Hande, Turkdogan, Dilsad, Baykan, Betul, Bebek, Nerses, Ozbek, Ugur, Hempelmann, Anne, Schulz, Herbert, Rüschendorf, Franz, Trucks, Holger, Nürnberg, Peter, Avanzini, Giuliano, Koeleman, Bobby P.C., and Sander, Thomas

Published
2012
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47. Epilepsy and Cerebral Palsy

Author

Ali A. Asadi-Pooya, Boulenouar Mesraoua, Osama Alalamy, Naim Haddad, Dirk Deleu, Covanis Athanasios, Gayane Melikyan, Musab Ali, and Hassan Al Hail

Subjects
Pediatrics, medicine.medical_specialty, Epilepsy, business.industry, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, medicine, medicine.disease, business, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cerebral palsy
Published
2019
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48. Autonomic Status Epilepticus in Panayiotopoulos Syndrome and Other Childhood and Adult Epilepsies: A Consensus View

Author

Ferrie, Colin D, Caraballo, Roberto, Covanis, Athanasios, Demirbilek, Veysi, Dervent, Aysin, Fejerman, Natalio, Fusco, Lucia, Grünewald, Richard A., Kanazawa, Osamu, Koutroumanidis, Michael, Lada, Christina, Livingston, John H, Nicotra, Alessia, Oguni, Hirokazu, Martinovic, Zarko, Nordli, Douglas R, Jr, Parisi, Pasquale, Scott, Rod C., Specchio, Nicola, Verrotti, Alberto, Vigevano, Federico, Walker, Matthew C., Watanabe, Kazuyoshi, Yoshinaga, Harumi, and Panayiotopoulos, Chrysostomos P

Published
2007

49. Exploration of the Genetic Architecture of Idiopathic Generalized Epilepsies

Author

Hempelmann, Anne, Taylor, Kirsten P., Heils, Armin, Lorenz, Susanne, PrudʼHomme, Jean-Francois, Nabbout, Rima, Dulac, Olivier, Rudolf, Gabrielle, Zara, Federico, Bianchi, Amedeo, Robinson, Robert, Mark Gardiner, R., Covanis, Athanasios, Lindhout, Dick, Stephani, Ulrich, Elger, Christian E., Weber, Yvonne G., Lerche, Holger, Nürnberg, Peter, Kron, Katherine L., Scheffer, Ingrid E., Mulley, John C., Berkovic, Samuel F., and Sander, Thomas

Published
2006

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